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    <name>A0AAN6P4D6_9PEZI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="1" type="ORF">C8A01DRAFT_21269</name>
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        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
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            <taxon>Sordariomycetidae</taxon>
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            <taxon>Parachaetomium</taxon>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <dbReference type="Proteomes" id="UP001303115">
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        <location>
            <position position="90"/>
        </location>
    </feature>
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        <source>
            <dbReference type="EMBL" id="KAK4031516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="90" mass="10632" checksum="EA68D04068409C70" modified="2024-10-02" version="1" fragment="single">MYEARTDQYRKTQIALAYAYWLQRPRPEASVFLVHASNAERFRQAYVYITQECQVPGYDDPKADVLLLVKAWLERKEHGLWLIVIDNADD</sequence>
</entry>
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    <accession>A0AAN6P4R9</accession>
    <name>A0AAN6P4R9_9PEZI</name>
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        <recommendedName>
            <fullName evidence="5">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_41893</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854735">
        <property type="protein sequence ID" value="KAK4031659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P4R9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="NACHT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF17">
        <property type="entry name" value="FUNGAL STAND N-TERMINAL GOODBYE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17100">
        <property type="entry name" value="NACHT_N"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
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        <property type="entry name" value="GPROTEINBRPT"/>
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        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="NACHT" evidence="5">
        <location>
            <begin position="381"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="912"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="954"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="996"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1034"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4031659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1034" mass="114853" checksum="13E3B48ACDAF9401" modified="2024-10-02" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P503</accession>
    <name>A0AAN6P503_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PNPLA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_20988</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854689">
        <property type="protein sequence ID" value="KAK4031861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P503"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4031861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="59" mass="6426" checksum="2BA15B1D8B06B251" modified="2024-10-02" version="1" fragment="single">FDIIGGTSTSGLIAFMLSRLHITIDEYSTLSDGVLETRPTATKWHCKTRASFGGGEESY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P5X3</accession>
    <name>A0AAN6P5X3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chaperonin 10-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_51559</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854869">
        <property type="protein sequence ID" value="KAK4031325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P5X3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052585">
        <property type="entry name" value="Lipid_raft_assoc_Zn_ADH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43482">
        <property type="entry name" value="PROTEIN AST1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43482:SF2">
        <property type="entry name" value="ZINC-BINDING DEHYDROGENASE FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G15030)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="4">
        <location>
            <begin position="71"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4031325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="449" mass="48445" checksum="2A37EF35A78037B1" modified="2024-10-02" version="1">MASFFRRLSLQKGRKAPSTSNVNGTGNFPREDEQPEPLAITIPETQTVLLLLAARQPYQLTENYAVPQLEGEREVLVRTQAIGLNPIDWKAPDFNFAIPTLPYISGRELAGEVVLVQKPSQTATRLKTRDRVLVISTDYRDLRKAAYQEYVVAFDYNTVRLPPSISPEEGSALGVAFVAAALALGVCMGVDFSSVLDGPDLFSLVREVAPELLPDDVRQECLDGILSHERATAGDWLAIWGGSSTSANLIIQLAKLAGLKTIAVVDKAKHGLRLANHKIIRTALLVDSHDPKRAVDIIHGNLNGNLRFGIDTRGRDSATSLLQALFSGNLAPSSSVPVAAMTDSSPPPSPPATPHNSTLLSAHLIGLAGLPKQSPPKGALFHTVPIKLFHEVPAIGRALVQWLERLLEKGLVSPPEIIDVEQGLDSVNKGLDRMRKGEISGGKLVVRVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P5X6</accession>
    <name>A0AAN6P5X6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_20563</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854620">
        <property type="protein sequence ID" value="KAK4032356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P5X6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033124">
        <property type="entry name" value="Ser_caboxypep_his_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF189">
        <property type="entry name" value="CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00560">
        <property type="entry name" value="CARBOXYPEPT_SER_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042848574" evidence="7">
        <location>
            <begin position="21"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4032356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="624" mass="68758" checksum="F96665E930497E23" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P6K9</accession>
    <name>A0AAN6P6K9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fungal-specific transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_40843</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854582">
        <property type="protein sequence ID" value="KAK4032701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P6K9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF10">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="31"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="61"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="112"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="555"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="689"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="117"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="692"/>
            <end position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4032701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="839" mass="91081" checksum="48C1BBC6FC2AC28D" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P6X2</accession>
    <name>A0AAN6P6X2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Prefoldin subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_40794</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 4">Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the prefoldin subunit alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854578">
        <property type="protein sequence ID" value="KAK4032755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P6X2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23156">
        <property type="entry name" value="Prefoldin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000001">
        <property type="entry name" value="Prefoldin subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016655">
        <property type="entry name" value="PFD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004127">
        <property type="entry name" value="Prefoldin_subunit_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12409">
        <property type="entry name" value="PREFOLDIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12409:SF0">
        <property type="entry name" value="PREFOLDIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02996">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016396">
        <property type="entry name" value="Prefoldin_subunit_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="142"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="182"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR016396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4032755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="202" mass="22842" checksum="44E3B124178A3554" modified="2024-10-02" version="1">MASTDKEAAARDATASNPRGIPYAPFVDKVEDYVTSRADVEPTLRRFQEMIAKYQFMEQNLQRRVVGLKDKLPDIRKTLDTVRFLKTRTPESDPIETTFELNDTLYAKAAIPPTDEVYLWLGANVMLSYPIDEAETLLDSKLQAAKLSLSNCEEDLDFLREQITTMEVAVARVYNWDVVQKRKDKEDEEKGKGKGAEGPSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P7Q9</accession>
    <name>A0AAN6P7Q9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_40267</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854541">
        <property type="protein sequence ID" value="KAK4033264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P7Q9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="13"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4033264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="271" mass="31296" checksum="B740766A54417CB6" modified="2024-10-02" version="1">MEKHFPSMIKKHCEVCKKTDALLRCGGCQTYYYCGRDHQVADRPTHKTTCKTIKGTKTKVQEEEAKLRARSAGDAELPPNALENGRLWLWKSARPYMLALFLHGEMLIRSWHRQGIEDALALFLEILRLNSGDNQGARFLIPSLYLRLGRNQEAYEFLKAWALQHTDRPEVKQLEDPCLAYLHVKNADATEDVELWAGNRGFLQLPVLSSLQLVKTRLLIGLEHLREFRPVRGKYCDDILERMPEVLADEDSIVKKPKEINQQLKDLFVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P8L3</accession>
    <name>A0AAN6P8L3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nuclear GTPase SLIP-GC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_19341</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854511">
        <property type="protein sequence ID" value="KAK4033768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P8L3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056024">
        <property type="entry name" value="DUF7605"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36681">
        <property type="entry name" value="NUCLEAR GTPASE, GERMINAL CENTER-ASSOCIATED, TANDEM DUPLICATE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36681:SF3">
        <property type="entry name" value="NUCLEAR GTPASE, GERMINAL CENTER-ASSOCIATED, TANDEM DUPLICATE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24564">
        <property type="entry name" value="DUF7605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin N-terminal" evidence="3">
        <location>
            <begin position="93"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7605" evidence="4">
        <location>
            <begin position="739"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="422"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="374"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="679"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="433"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="466"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4033768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1030" mass="113492" checksum="652B9775A1C069C8" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P950</accession>
    <name>A0AAN6P950_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">MYND domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_40455</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854552">
        <property type="protein sequence ID" value="KAK4033097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P950"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4033097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="235" mass="26477" checksum="892884348616117B" modified="2024-10-02" version="1">MSSTAVYRPLAICARCKRLTPTHKAGVKQCDCCHAFYCSTDCFEATKTENPKLILPGAQGGSNPSWYEPATYEATQGLHAAPGQPFTRLDRGTYLHDRPRLDVFRLLLDCYRLRLDDDIKIYGIPVPATLRHGFHRFLDLAAQRPNLLPPWWDDEAVVECLTIFDTGDNDPAAEEWSTLAHRVSSAEVNTHYGNAYMDVQLRLLGEVVYQRAPGNQKGKEILDMMVEHERRAQGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P988</accession>
    <name>A0AAN6P988_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_39448</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854496">
        <property type="protein sequence ID" value="KAK4034068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P988"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4034068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="472" mass="51353" checksum="D75176474AF413B8" modified="2024-10-02" version="1">MPSLAEQHKHLRLNNEIKPLLHRYGIPYDKKANKESLLALLQANGVPLDRVQQSATAPDLSAVEVLGLEQIARDYPPLGSDESSGGGLDEDSAGGMEEDSAGGMEEDSAGGMDEDSAGGRDEDSSPGLGSDSTSATTRSVKRLVDLPDHKGHAGRARQAGIPDPANKLTDLERRLLLEYPAASACLPTIKRGLGQANLKQKVTGLVDWFASVAKSQNMPVGPALVFFDSYLSSPNLDFVAYLLDKDGCRESWYAHSSNPNARKQAAKRLGNLWSLALDSPEATTTATASSDPTADQDFFMEVIDPYDGMPTRGKVIGLHMSKKDTLGVRLPSLSEQYPDLGRGLWVECKSGKELEAYKAYVKAFPKGKLSSAPAGFLAGCQTTADFHLDRVFRMKWGRGYHTYAYGRPKNGDFRHLMMFTKTTLSPKLKGAAAVMEMLQTHMERTGQSTYEGTDDAQPEVIRLRARRSVTVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PA01</accession>
    <name>A0AAN6PA01_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NAD-dependent histone deacetylase HST3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_18702</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854477">
        <property type="protein sequence ID" value="KAK4034509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PA01"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF8">
        <property type="entry name" value="NAD-DEPENDENT HISTONE DEACETYLASE HST3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="6">
        <location>
            <begin position="7"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="61"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="117"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="370"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="635"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="765"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="870"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="150"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="217"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="245"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="397"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="448"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="659"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="724"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="796"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="819"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="839"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="902"/>
            <end position="915"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4034509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1109" mass="119625" checksum="28F7946E25D53169" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PA08</accession>
    <name>A0AAN6PA08_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_49101</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="MU854476">
        <property type="protein sequence ID" value="KAK4034516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PA08"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042669035" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="24"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="48"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4034516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="553" mass="59558" checksum="60022770FA634ED0" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PAD9</accession>
    <name>A0AAN6PAD9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GPI anchored protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_39800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854512">
        <property type="protein sequence ID" value="KAK4033755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PAD9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042819934" description="GPI anchored protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4033755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="259" mass="25890" checksum="BEC4D75AFA6118CB" modified="2024-10-02" version="1" fragment="single">MVAFSRSLAAAGWLLAGAAAVAHERFVAVETGAVLSPRQYKMSPAHPLAKREGACDAGWHPCNEIGPPGETLCCPNTHYCIVDPTNITHGGCCHIGLECGSPCAASQYQCAITDTLTTSGTTTTSLREACCPRHCTGTSEFQCAQTLGGGCCQYGNRCATNSQCLFTPPPTTSINPSLIAPPGCETGQISCAASLGGGCCAASQSCTLIDATAHCADDPITPTGSGVSVVQAPQTGLSAGATAGVAVGVVVGAGVILGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PAG2</accession>
    <name>A0AAN6PAG2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 17">Delta-aminolevulinic acid dehydratase</fullName>
            <ecNumber evidence="5 17">4.2.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">C8A01DRAFT_40315</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 17">
            <text>2 5-aminolevulinate = porphobilinogen + 2 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="4.2.1.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 17">Homooctamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the ALAD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.24" evidence="5 17"/>
    <dbReference type="EMBL" id="MU854544">
        <property type="protein sequence ID" value="KAK4033218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PAG2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004655">
        <property type="term" value="F:porphobilinogen synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04824">
        <property type="entry name" value="eu_ALAD_PBGS_cysteine_rich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000048">
        <property type="entry name" value="Delta-aminolevulinic acid dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001731">
        <property type="entry name" value="ALAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030656">
        <property type="entry name" value="ALAD_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006762">
        <property type="entry name" value="PRK09283.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11458">
        <property type="entry name" value="DELTA-AMINOLEVULINIC ACID DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11458:SF0">
        <property type="entry name" value="DELTA-AMINOLEVULINIC ACID DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00490">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001415">
        <property type="entry name" value="Porphbilin_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00144">
        <property type="entry name" value="DALDHYDRTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01004">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00169">
        <property type="entry name" value="D_ALA_DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="10 17" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 17" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="14">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="14">
        <location>
            <position position="305"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>5-aminolevulinate</name>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>5-aminolevulinate</name>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>5-aminolevulinate</name>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="371"/>
        </location>
        <ligand>
            <name>5-aminolevulinate</name>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU004161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAK4033218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="382" mass="41453" checksum="0BC80C5AFD272C67" modified="2024-10-02" version="1">MSFSSLVQNLSLRDPSAPRRRGEASVSTVDDRASHISMAKSYTSTAATSVSIAGDIGSQLHAGYSHPLARSWQAERQLTKSMLIYPLFISDQDDEEVLIPSLPGQCRRGINKLVPFLEPLVHKGLRSVILFGVPMMPGTKDALGTSADDPEGPVIRSIRLLRQRFPHLYIVCDVCLCEYTSHGHCGILRDDGSLNNQLSVDRISDVAVAYARAGAHCVAPSDMNDGRIRAIKLKLIEEGIVHNVTLMSYAAKFSGCLYGPFRDAAGSSPSFGDRRCYQLPPGGRGLARRAIVRDINEGADIIMVKPAGQYLDIIADAKELGRDLPIAAYQVSGEFAMIHAAAKAGVFDLKAMAFESTEGILRAGATIIVSYFVPEFLDWLSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PAG4</accession>
    <name>A0AAN6PAG4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Derlin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_20228</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Endoplasmic reticulum membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the derlin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854580">
        <property type="protein sequence ID" value="KAK4032736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PAG4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007599">
        <property type="entry name" value="DER1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11009">
        <property type="entry name" value="DER1-LIKE PROTEIN, DERLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04511">
        <property type="entry name" value="DER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="227"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="228"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4032736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="257" mass="28680" checksum="BAFA97F28A88B860" modified="2024-10-02" version="1">MSSEIMDAYWAAPPMARTLATAIVLTSIPVHFGLLSYTWFYFTEDRLFRFPPEIWRLATNFFLSGPKLGIIMDPYFAYQYLNQLERANPKFPRKEDVLWYLMTVGGFIILLNRVFLGGGFFLDGLIMALAYTSSQDQRGVKTNFFFFTVPAQTIPYCMLVASLLMNPASIPLQITGIVSAHAHDFLSRLWPQFGGGWNILSTPSFVSYLVQTPRVLQRDYGTAIRQPAAASGSSTGASTGSVLPDSWKTRGAGQRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PAR5</accession>
    <name>A0AAN6PAR5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_20114</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the secreted LysM effector family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854568">
        <property type="protein sequence ID" value="KAK4032871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PAR5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052210">
        <property type="entry name" value="LysM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997">
        <property type="entry name" value="AM15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997:SF2">
        <property type="entry name" value="LYSM DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042915673" description="LysM domain-containing protein" evidence="6">
        <location>
            <begin position="24"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="7">
        <location>
            <begin position="42"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="7">
        <location>
            <begin position="161"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="7">
        <location>
            <begin position="261"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="7">
        <location>
            <begin position="476"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="400"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="412"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4032871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="525" mass="55539" checksum="7DF021AFC802C60F" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PAX2</accession>
    <name>A0AAN6PAX2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transporter-like protein 24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_50362</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854561">
        <property type="protein sequence ID" value="KAK4032961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PAX2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000034">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000364">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF54">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="395"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="432"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="464"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="67"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4032961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="523" mass="57875" checksum="AA779F41C1B46930" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PBL3</accession>
    <name>A0AAN6PBL3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sphingolipid long chain base-responsive protein PIL1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_17914</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854445">
        <property type="protein sequence ID" value="KAK4035401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PBL3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036286">
        <property type="term" value="C:eisosome filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070941">
        <property type="term" value="P:eisosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000005">
        <property type="entry name" value="Sphingolipid long chain base-responsive pil1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028245">
        <property type="entry name" value="PIL1/LSP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31962">
        <property type="entry name" value="SPHINGOLIPID LONG CHAIN BASE-RESPONSIVE PROTEIN PIL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31962:SF1">
        <property type="entry name" value="SPHINGOLIPID LONG CHAIN BASE-RESPONSIVE PROTEIN PIL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13805">
        <property type="entry name" value="Pil1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="290"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="167"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="300"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="326"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="354"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4035401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="366" mass="40838" checksum="78B35317F88860EF" modified="2024-10-02" version="1">MHRTYSMRATRAPTASQIQNPPPPTSSTKSGRLFGRGGLGHALRRNAAGAFGPDLAKKLSQLVKMEKNVMRSLELVAKERMEVAQQLSLWGEACDEDVSDVTDKLGVLLYEIGELEDQYVDRYDQYRVTVKSIRNIEASVQPSRDRKQKITDQIAQLKYKEPNSPKIVVLEQELVRAEAESLVAEAQLSNITREKIKAAYSYQFDALREHCEKVAIIAGYGKHLLELIDDTPVTPGETRPAYDGYEASKAIIQDCEDSLTNWVTQNAAVSAKLSTRARTLSQRRRNNIKARTEGQQLHGHGHDLSAQDPPLSDRDAWMPAGQHEYVEDEEDEGEEDDLDAPSHSAVDTEASLNGEHRGRNHDPVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PBS9</accession>
    <name>A0AAN6PBS9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_39077</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854479">
        <property type="protein sequence ID" value="KAK4034462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PBS9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4034462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="195" mass="22245" checksum="FD057C5AAC263E0D" modified="2024-10-02" version="1">MCFGKYVRFFCPQAIMQHPLCPDTNPNGPIGFYATMWVETKFVCCGNHPGDCRHCPELQEPGHIEIQNACALECDECRDRLRREREEMAEMGGLDKGEDTDEMMTETETEIETEVETEVETEVEVEMGSDMDAEVETEVETEMGVDEEEEEKEKEKEEKEKEKEEKEEVFVDVDCDCQGCQEAREFNATAPSAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PCD6</accession>
    <name>A0AAN6PCD6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_38646</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854462">
        <property type="protein sequence ID" value="KAK4034880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PCD6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4034880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="402" mass="44310" checksum="61C763D8EF6BAC20" modified="2024-10-02" version="1">MAAQTDGCLRLLHHRALSGTPPRSRRLALVVPEARPSAAATWIFLLSATQFTQPALTLMKKASFETQWQRNSSRVTFAGQSLGESSALAAVADITDQVTGGGNDRGYHSLRDNLKGIRQAVDAKTGEPVDEAKYEKYILEHSGIPVIDPELLDGYEPNKKQELATWGLTIANFAAVLFHGAPGRGQEQDRAVGHQQAACPLVNFPKAALLFFGRALGSFNKQDREDDEEYVNSAQTRGLDEHGVYEVMATLMQCKEKWIAVNINSVQTRALDMDSFNNVMATLMQRKEKWIIVKLLSRLQATEDEHLRHSLTKFFEDCNLEFRTGGSSKTGSRTPFSARLGNLSYDAAVTEFFEDCNPGSHKHFLASSTDVADNKISSVNEGSILIQLLGISALIRMILRGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PCI1</accession>
    <name>A0AAN6PCI1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">C8A01DRAFT_37668</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">ATP-dependent RNA helicase required for 60S ribosomal subunit synthesis. Involved in efficient pre-rRNA processing, predominantly at site A3, which is necessary for the normal formation of 25S and 5.8S rRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="EMBL" id="MU854430">
        <property type="protein sequence ID" value="KAK4038424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PCI1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00268">
        <property type="entry name" value="DEADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000008">
        <property type="entry name" value="ATP-dependent RNA helicase RhlB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044742">
        <property type="entry name" value="DEAD/DEAH_RhlB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 13" id="KW-0347">Helicase</keyword>
    <keyword evidence="7 13 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="212"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="434"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="69"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="92"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="114"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAK4038424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="617" mass="67333" checksum="474FD04EBB6FAC52" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PCQ5</accession>
    <name>A0AAN6PCQ5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">asparagine synthase (glutamine-hydrolyzing)</fullName>
            <ecNumber evidence="1">6.3.5.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">C8A01DRAFT_49544</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-aspartate + L-glutamine + ATP + H2O = L-asparagine + L-glutamate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12228"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Amino-acid biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.4" evidence="1"/>
    <dbReference type="EMBL" id="MU854501">
        <property type="protein sequence ID" value="KAK4033966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PCQ5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008308">
        <property type="term" value="F:voltage-gated monoatomic anion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00712">
        <property type="entry name" value="AsnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07306">
        <property type="entry name" value="Porin3_VDAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000050">
        <property type="entry name" value="Asparagine synthetase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="entry name" value="Porin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006426">
        <property type="entry name" value="Asn_synth_AEB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050795">
        <property type="entry name" value="Asn_Synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033738">
        <property type="entry name" value="AsnB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001925">
        <property type="entry name" value="Porin_Euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027246">
        <property type="entry name" value="Porin_Euk/Tom40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01536">
        <property type="entry name" value="asn_synth_AEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11772">
        <property type="entry name" value="ASPARAGINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11772:SF2">
        <property type="entry name" value="ASPARAGINE SYNTHETASE [GLUTAMINE-HYDROLYZING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01459">
        <property type="entry name" value="Porin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00185">
        <property type="entry name" value="EUKARYTPORIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00558">
        <property type="entry name" value="EUKARYOTIC_PORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="11">
        <location>
            <begin position="2"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="259"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK4033966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="823" mass="90782" checksum="D466342CC5669C80" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PD48</accession>
    <name>A0AAN6PD48_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_49691</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854509">
        <property type="protein sequence ID" value="KAK4033812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PD48"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF10">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="336"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="392"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="426"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="463"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="40"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="517"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="528"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4033812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="539" mass="59112" checksum="E6886295CE230985" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PD71</accession>
    <name>A0AAN6PD71_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GAR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_37265</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854419">
        <property type="protein sequence ID" value="KAK4038777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PD71"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.20">
        <property type="entry name" value="Gas2-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003108">
        <property type="entry name" value="GAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036534">
        <property type="entry name" value="GAR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02187">
        <property type="entry name" value="GAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143575">
        <property type="entry name" value="GAS2 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51460">
        <property type="entry name" value="GAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAR" evidence="5">
        <location>
            <begin position="667"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="352"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="629"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="746"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="895"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="22"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="419"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="528"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="548"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="655"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="837"/>
            <end position="852"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4038777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="961" mass="103318" checksum="6EFD94B308E5096F" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PD96</accession>
    <name>A0AAN6PD96_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">HC-toxin efflux carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_49022</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854471">
        <property type="protein sequence ID" value="KAK4034643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PD96"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF198">
        <property type="entry name" value="AZOLE RESISTANCE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="312"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="351"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="403"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="435"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="513"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="48"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="540"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4034643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="571" mass="60348" checksum="08A46E70C7674A5E" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PDL3</accession>
    <name>A0AAN6PDL3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">laccase</fullName>
            <ecNumber evidence="5">1.10.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">C8A01DRAFT_17866</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Lignin degradation and detoxification of lignin-derived products.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4 hydroquinone + O2 = 4 benzosemiquinone + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11276"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17594"/>
            <dbReference type="ChEBI" id="CHEBI:17977"/>
            <dbReference type="EC" id="1.10.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.10.3.2" evidence="5"/>
    <dbReference type="EMBL" id="MU854443">
        <property type="protein sequence ID" value="KAK4035452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PDL3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052716">
        <property type="term" value="F:hydroquinone:oxygen oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046274">
        <property type="term" value="P:lignin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13854">
        <property type="entry name" value="CuRO_1_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13880">
        <property type="entry name" value="CuRO_2_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13901">
        <property type="entry name" value="CuRO_3_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000021">
        <property type="entry name" value="Extracellular dihydrogeodin oxidase/laccase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000078">
        <property type="entry name" value="Laccase-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000046">
        <property type="entry name" value="Multicopper oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF87">
        <property type="entry name" value="LACCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0439">Lignin degradation</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042864950" description="laccase" evidence="13">
        <location>
            <begin position="22"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="16">
        <location>
            <begin position="96"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="14">
        <location>
            <begin position="215"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="15">
        <location>
            <begin position="439"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAK4035452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="619" mass="68425" checksum="EAE32C781333EDA4" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PDY8</accession>
    <name>A0AAN6PDY8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Histidinol-phosphatase</fullName>
            <shortName evidence="8">HolPase</shortName>
            <ecNumber evidence="3 8">3.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_18943</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>L-histidinol phosphate + H2O = L-histidinol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14465"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="3.1.3.15"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 8/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the PHP hydrolase family. HisK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.15" evidence="3 8"/>
    <dbReference type="EMBL" id="MU854489">
        <property type="protein sequence ID" value="KAK4034217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PDY8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004401">
        <property type="term" value="F:histidinol-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12110">
        <property type="entry name" value="PHP_HisPPase_Hisj_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000059">
        <property type="entry name" value="Histidinol-phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010140">
        <property type="entry name" value="Histidinol_P_phosphatase_HisJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01856">
        <property type="entry name" value="hisJ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21039">
        <property type="entry name" value="HISTIDINOL PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21039:SF0">
        <property type="entry name" value="HISTIDINOL-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="PHP domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PHP" evidence="9">
        <location>
            <begin position="5"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4034217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="310" mass="35002" checksum="71CC62823E3F2D80" modified="2024-10-02" version="1">MAFTMHSHSGQFCPGHAKDQLEDIVLHAIKVGYKTIGLTEHMPRTDLADLYPEELTPSPEASLASLAPRHTHYLTEALRLREKYAPQIHILIAFEGEWIRSSYGALIRSLAADPAVDYFIGSIHHTRGIPIDFDAAMYAQAVTACGGTEEGLFEAYFDEQCEMLREVRPRVVGHFDLVRLFSAAPGRELRKEWRGVWERVVRNLEVVRGYGGWLECNTSGLRKGLEEAYPKREIAEEWVRMGGRFTFGDDSHGVAQVGTNYARGLEYLEGMGVTELWTLERREVGGGEAELVEKSVSIEEFRASLRLEWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PEV0</accession>
    <name>A0AAN6PEV0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_37262</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854419">
        <property type="protein sequence ID" value="KAK4038773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PEV0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042983497" evidence="2">
        <location>
            <begin position="28"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4038773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="150" mass="14638" checksum="6228F7F47D9CBDF8" modified="2024-10-02" version="1">MKRTHITLPSLQVAATAFLALTCQAAAELYCVDKATSEVVAAENCEGDVGDFATVDGAPGAALGAVIAKRQDTDDDDNNNKSKRDLEFIAEAAAKLAELKLVAGGFGNGGACECSSSGEKGGVSGGVSGSSGGGGGGVVGWSRAGGGRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PF14</accession>
    <name>A0AAN6PF14_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_17160</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the peroxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854419">
        <property type="protein sequence ID" value="KAK4038775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PF14"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.520.10:FF:000020">
        <property type="entry name" value="Peroxisomal ascorbate peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.420.10">
        <property type="entry name" value="Peroxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051589">
        <property type="entry name" value="Sialate-O-sulfotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45964">
        <property type="entry name" value="WSCD FAMILY MEMBER CG9164"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45964:SF5">
        <property type="entry name" value="WSCD FAMILY MEMBER CG9164"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00458">
        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042923889" evidence="4">
        <location>
            <begin position="22"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="domain" description="Plant heme peroxidase family profile" evidence="5">
        <location>
            <begin position="123"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="6">
        <location>
            <begin position="593"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="6">
        <location>
            <begin position="707"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="6">
        <location>
            <begin position="836"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="6">
        <location>
            <begin position="953"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="807"/>
            <end position="832"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4038775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1046" mass="108565" checksum="830E95119CE1D3ED" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PF39</accession>
    <name>A0AAN6PF39_9PEZI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_18055</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854450">
        <property type="protein sequence ID" value="KAK4035256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PF39"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4035256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="130" mass="14913" checksum="A399227E161AF4C9" modified="2024-10-02" version="1">MGGAGSTSFKPVAPLIRRLKFERRNGDQYFYNGEARDFRDFVNLTEIHAVCGEGLRGWHGVSEDHSWPRGKEKVFMIVPDDGRMMRSIELDKMFDNALKEEYRRTDERNGSHGRSMDLNTRAVSSELIGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAN6PFA2_9PEZI</name>
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        <recommendedName>
            <fullName evidence="10">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">C8A01DRAFT_47549</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Parachaetomium inaequale</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Variant histone H2A which can replace H2A in some nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. This variant is enriched at promoters, it may keep them in a repressed state until the appropriate activation signal is received. Near telomeres, it may counteract gene silencing caused by the spread of heterochromatin proteins. Required for the RNA polymerase II and SPT15/TBP recruitment to the target genes. Involved in chromosome stability.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the histone H2A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854416">
        <property type="protein sequence ID" value="KAK4038910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PFA2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000791">
        <property type="term" value="C:euchromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000021">
        <property type="entry name" value="Histone H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 10" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="12">
        <location>
            <begin position="22"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Histone H2A C-terminal" evidence="13">
        <location>
            <begin position="105"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF16211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK4038910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="143" mass="15217" checksum="2CE4552F418CBDD9" modified="2024-10-02" version="1">MAGGKGKSSGGKSSGGKTSGVDGPKKQQSHSARAGLQFPCGRVKRFLKQNTQNKMRVGAKAAVYVTAVLEYLTAEVLELAGNAAKDLKVKRITPRHLQLAIRGDEELDTLIRATIAFGGVLPHINRALLLKVEQKKKAKAAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PFA7</accession>
    <name>A0AAN6PFA7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_16432</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854396">
        <property type="protein sequence ID" value="KAK4039597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PFA7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12526:SF510">
        <property type="entry name" value="D-INOSITOL 3-PHOSPHATE GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12526">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="3">
        <location>
            <begin position="266"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4039597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="411" mass="46037" checksum="7DCD34D6CE588FF9" modified="2024-10-02" version="1">MRVFLVQTAQGLTPSSGGYKANVNLLRSLSSQGHATAQICYAVESEIDQYARRAEIQGIPPNVTHEQLPVVDKEGFVHDLFIKTFTDEHERNDLSLRMKTLIALFSKHITDFKPTHVIFNDPITMKITASHKDRKSFKRINIIHTAEQLPFGPFVAGVDGHCLSPRVENDMLRDLDGIWSVSMAVKDYAWTYGRLTTTFLVHPPMTYLDKVTGGMPVVRNNIDKYEIGMVNPCPHKGLPILVALAQKFPQMTFVTWKSWGSRTAHIAQLQALPNVKIEPTTKNTDEIWDRIKVLLAPSLWHEAWGIVVTEAQLRGIPVIASNAGGLPEAKIGLPYCIPVKEVTGERHANGDYVVPDQDIGPWEEALAKVMTDREEYQALQALTATKAGDWLCGLDPRAHEKWLLSMMKAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PFD6</accession>
    <name>A0AAN6PFD6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_38145</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854445">
        <property type="protein sequence ID" value="KAK4035406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PFD6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="16"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4035406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="309" mass="35118" checksum="F0EE7999B6A14B41" modified="2024-10-02" version="1">MRWSTSKAIVGSLEGCDVVRVLVGDEQRDFAIHRKLLSESCSFFKTHIEAIPAPSSPQDCDDGEDSVLWLPNEAPDMFEIFVLWLYQRRRFPTFIDSALQTMCPDKFRTLRTNLVRLHLFAAIIDLPGAQDAAMDTLQDMYLRFDWDMSPRFLAFLYGDCDAQHAVRLRKWATAMLAWTLHGADKAAARHDADKLFAAYPELKADYHLHLQKMAQSRADVRIKNPQLRLPANGLRSGERLFGFRQCTFHSHRATVGEGTCPHALALGHTPAPLPPVPRRDKEDVESDREEADIISPVRDLNEVSYLDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PFL0</accession>
    <name>A0AAN6PFL0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD dependent oxidoreductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_16080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854386">
        <property type="protein sequence ID" value="KAK4040001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PFL0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050464">
        <property type="entry name" value="Zeta_carotene_desat/Oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923:SF26">
        <property type="entry name" value="FMN REDUCTASE LOT6, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G06600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042821831" description="FAD dependent oxidoreductase" evidence="1">
        <location>
            <begin position="21"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4040001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="485" mass="52485" checksum="6E00CA2D4F9276F6" modified="2024-10-02" version="1">MQHIMRVGVSLGCLAVSAAAASVKCRDTCSRTIDRDVVVVGGGASGAHAAVWLRDNGHSVVVVEKADQLGGHTNFYSDKASGKAINVGVQAWMEYKDAFDFPKRMNVSTSGSMSFTPNTAQYIDYKTGKPVPDYKAPEAADMYAALQRYLDVIEKYEDMVLPGFFNFPEPASIPEDLLMPFGEFVEKYDLAAAVPQIWDSTAQGLGNTMNVPTIWVVQASGIPMVRALLGTGAAAVPASGRLYDLFESVANFLGDDVLYSSTVVSAKRYNNRNPQKDISLQVKGADGKTTCIEAKRLLLAIEPTAENLAPFDLDNTEKEILGKFKFPTVYAGILHHPSLQTLNAYTDRSPEPASYNYTLFPVAPQVGRIDYLGGTENLFQFTAVGTGDDTAESMQALIAKSIDTMVAAGTLPAAEGSVSFDIFANHGHMHAHVSADELRAGFMQKLYSLQGLRNTYYTGAAFSAGFTTVLWEYNKVLLPKLVEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PG29</accession>
    <name>A0AAN6PG29_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glutamate--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Glutamyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">C8A01DRAFT_36591</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Glu) + L-glutamate + ATP = L-glutamyl-tRNA(Glu) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.17" evidence="3"/>
    <dbReference type="EMBL" id="MU854400">
        <property type="protein sequence ID" value="KAK4039463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PG29"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017102">
        <property type="term" value="C:methionyl glutamyl tRNA synthetase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004818">
        <property type="term" value="F:glutamate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000037">
        <property type="entry name" value="Glutamine--tRNA ligase cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.240.10:FF:000004">
        <property type="entry name" value="Glutamyl-tRNA synthetase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="entry name" value="Ribosomal Protein L25, Chain P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02076">
        <property type="entry name" value="Glu_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050132">
        <property type="entry name" value="Gln/Glu-tRNA_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004526">
        <property type="entry name" value="Glu-tRNA-synth_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020059">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_codon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_bL25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_bL25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049437">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00463">
        <property type="entry name" value="gltX_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097:SF5">
        <property type="entry name" value="GLUTAMATE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097">
        <property type="entry name" value="GLUTAMINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03950">
        <property type="entry name" value="tRNA-synt_1c_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20974">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="Ribosomal protein L25-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12 17" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic" evidence="14">
        <location>
            <begin position="112"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding" evidence="15">
        <location>
            <begin position="431"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA synthetases class I (E and Q) anti-codon binding" evidence="16">
        <location>
            <begin position="534"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="206"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF03950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF20974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAK4039463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="632" mass="70920" checksum="10FF67E8256BA473" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PGE2</accession>
    <name>A0AAN6PGE2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_38025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854441">
        <property type="protein sequence ID" value="KAK4038065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PGE2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20558">
        <property type="entry name" value="CYCLIN_ScPCL7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF94">
        <property type="entry name" value="PHO85 CYCLIN-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="132"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="433"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4038065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="559" mass="59884" checksum="1CF33260FA6BC6DE" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PGW8</accession>
    <name>A0AAN6PGW8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">KRR1 small subunit processome component</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">KRR-R motif-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">C8A01DRAFT_35228</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly. Essential for vegetative growth.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3. Interacts with snoRNA U3. Interacts with MPP10, KRI1 and with ribosomal proteins RPS1A, RPS4A, RPS4B, RPS8A, RPS8B, RPS11A, RPS11B, RPS13, RPS24, RPS25, RPL4A, RPL7B, RPL8, RPL23, RPL25 and RPL28.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
            <location evidence="1 11">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the KRR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854370">
        <property type="protein sequence ID" value="KAK4040758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PGW8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22393">
        <property type="entry name" value="KH-I_KRR1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22394">
        <property type="entry name" value="KH-I_KRR1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000011">
        <property type="entry name" value="KRR1 small subunit processome component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000014">
        <property type="entry name" value="KRR1 small subunit processome component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041174">
        <property type="entry name" value="KRR1-like_KH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048550">
        <property type="entry name" value="KRR1-like_KH1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048548">
        <property type="entry name" value="KRR1-like_KH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048549">
        <property type="entry name" value="KRR1-like_KH2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024166">
        <property type="entry name" value="rRNA_assembly_KRR1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12581">
        <property type="entry name" value="HIV-1 REV BINDING PROTEIN 2, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12581:SF0">
        <property type="entry name" value="KRR1 SMALL SUBUNIT PROCESSOME COMPONENT HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17903">
        <property type="entry name" value="KH_KRR1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21800">
        <property type="entry name" value="KH_KRR1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006515">
        <property type="entry name" value="KRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 11" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="6 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 11" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="K Homology" evidence="13">
        <location>
            <begin position="120"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="233"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="277"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="311"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR006515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK4040758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="323" mass="37220" checksum="32EB22A0EED05871" modified="2024-10-02" version="1">MPSTHKKEKPWDTDDIDKWKVDPFTKDESSGPFLEESSFMTLFPKYRERYLKDSWPLVTKALDKNGITATLDLVEGSMTVKTTRKTFDPAAILNARDLIKLLARSVPAPQAIKILEDGMACDIIKIRGMVGNKERFVKRRQRILGQNGTTLKALELLTETYIMVHGNTVSVMGPFKGLKEVRRVVEDTMQNIHPIYLIKELMIKRELAKDPALAHEDWSRYLPNFKKRTLSKRRTPFKVADKSKKTYTPFPPAPEKSKVDQQIETGEYFLSKQAKHRAAEAERAEQAKQKKEEKKREREREYVPPEEGAGKPKKRKTAHPVED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PGX8</accession>
    <name>A0AAN6PGX8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Imidazole glycerol phosphate synthase hisHF</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="12">Glutaminase</fullName>
                <ecNumber evidence="12">3.5.1.2</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="12">Cyclase</fullName>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="17" type="ORF">C8A01DRAFT_46701</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 12">IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The glutaminase domain produces the ammonia necessary for the cyclase domain to produce IGP and AICAR from PRFAR. The ammonia is channeled to the active site of the cyclase domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 12">
            <text>5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="4.3.2.10"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 12">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the HisA/HisF family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11 12">In the C-terminal section; belongs to the HisA/HisF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.2" evidence="12"/>
    <dbReference type="EMBL" id="MU854389">
        <property type="protein sequence ID" value="KAK4039883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PGX8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000107">
        <property type="term" value="F:imidazoleglycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01748">
        <property type="entry name" value="GATase1_IGP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04731">
        <property type="entry name" value="HisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000094">
        <property type="entry name" value="Imidazole glycerol phosphate synthase hisHF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000039">
        <property type="entry name" value="Imidazole glycerol phosphate synthase hisHF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00278">
        <property type="entry name" value="HisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006062">
        <property type="entry name" value="His_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004651">
        <property type="entry name" value="HisF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050064">
        <property type="entry name" value="IGPS_HisA/HisF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014640">
        <property type="entry name" value="IGPS_HisHF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010139">
        <property type="entry name" value="Imidazole-glycPsynth_HisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00735">
        <property type="entry name" value="hisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01855">
        <property type="entry name" value="IMP_synth_hisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21235:SF2">
        <property type="entry name" value="IMIDAZOLE GLYCEROL PHOSPHATE SYNTHASE HISHF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21235">
        <property type="entry name" value="IMIDAZOLE GLYCEROL PHOSPHATE SYNTHASE SUBUNIT HISF/H IGP SYNTHASE SUBUNIT HISF/H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00977">
        <property type="entry name" value="His_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036936">
        <property type="entry name" value="IGPS_HisHF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 12 15" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4 12" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5 12 15" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="3 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 12" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="16">
        <location>
            <begin position="6"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="PRFAR binding" evidence="14">
        <location>
            <begin position="362"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="PRFAR binding" evidence="14">
        <location>
            <begin position="400"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="PRFAR binding" evidence="14">
        <location>
            <begin position="472"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="PRFAR binding" evidence="14">
        <location>
            <begin position="498"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="PRFAR binding" evidence="14">
        <location>
            <begin position="521"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="13">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="13">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="13">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="243"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="402"/>
        </location>
    </feature>
    <feature type="binding site" description="covalent" evidence="14">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="467"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00055946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00061106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR036936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR036936-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR036936-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAK4039883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="552" mass="59593" checksum="B9238FAEC713FD85" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PH16</accession>
    <name>A0AAN6PH16_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_46657</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854388">
        <property type="protein sequence ID" value="KAK4039928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PH16"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="11"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4039928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="260" mass="28566" checksum="DDA36EFCCD9FF6D8" modified="2024-10-02" version="1">MSDRINFPSGFGMKDLVAYGNTGMVLLDKDTDMVIKSPHDEKSAVALTKEQQIYERFVQRCGHKSILCYHGTFESGIRLEYASHGNIRSYLDDHPADEARRMRRLDVKLADFAGSSLDGSPLLIGVTPSHEYPGPLLSIEADLFALGYTLYEIVNESQPYAGLSDEVILDHYSKGKFPETGSLGSVGSIITKCWRGEYKECKQVVCDLKVKAARQRLLASSSHNNILPATYTPVYSDLFVAIVVVVAVSALIIKRSPGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PH57</accession>
    <name>A0AAN6PH57_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_35065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854367">
        <property type="protein sequence ID" value="KAK4040893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PH57"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4040893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="166" mass="18339" checksum="4797B64820607A4C" modified="2024-10-02" version="1">MPADTLPLNPPPPYHATDTNPTWPPTTLVLAGQSIHASTATAPSPPLYRLNRGIASLTHATAAVELTRVERTVLLTKGGREPTVRARPRDIYTLKHTRTRTAALTGGRLPAADSPRYYIEAVSRRRRGTVFGDLGCSSFGVPRFVEDGRQPPVFEIRQRRRRDGTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PHF3</accession>
    <name>A0AAN6PHF3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MOSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_16931</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854412">
        <property type="protein sequence ID" value="KAK4039044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PHF3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005303">
        <property type="entry name" value="MOCOS_middle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237">
        <property type="entry name" value="MOLYBDOPTERIN COFACTOR SULFURASE MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237:SF23">
        <property type="entry name" value="MOSC DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_7G05900)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03476">
        <property type="entry name" value="MOSC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="MOSC" evidence="2">
        <location>
            <begin position="276"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4039044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="457" mass="51477" checksum="91FFFB033964A858" modified="2024-10-02" version="1">MDGSTAPRSGPMVDASSAFILAVTIFAFFLPILLYFPPVPPSKRDALRETHIQVGVGPSESGLRGHHKDSRRVRNDAQEAAAAAKIRSLWIYPLKSCKGIEVRQSRVLPTGLEFDRLYTFAQLKSPFPAGVQSAGTEKEEWHFITQRQFPLLATVQVDLFVPDLVKTNQPPSHPSSKEEPFLLVRFPWQERGLRGLLALAAAKLARGWRARPEKDFVLPVAFPPEEEIAARGYAREGVTIWRDTVAALNMESELPRELALYLGVSNRLGLFRVDPARLRHVYRCAPPQAEAGYQPVAGFQDAYPLHLLNLTSVRDFDAKIDKDEALRELDPRRFRANIIVDGDDDTPYDEETWKKIRFNPGPGNKRDPSTFHVSCRTVRCKLPNVDQDTGHRHPVQPDKALRKFREVDEGAKHMGCLGMQVTPLFPKTNTPEDLESWVEVGMSVQVLERGNHVYIPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PHF4</accession>
    <name>A0AAN6PHF4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_15168</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854365">
        <property type="protein sequence ID" value="KAK4041028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PHF4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35006:SF3">
        <property type="entry name" value="GLYOXALASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_3G06020)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35006">
        <property type="entry name" value="GLYOXALASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G14830)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="529"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="176"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="365"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="444"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="565"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4041028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="595" mass="64707" checksum="F2F74A2BD65CCA3D" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PHU3</accession>
    <name>A0AAN6PHU3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_45676</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the secreted LysM effector family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854363">
        <property type="protein sequence ID" value="KAK4041141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PHU3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052210">
        <property type="entry name" value="LysM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997">
        <property type="entry name" value="AM15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997:SF1">
        <property type="entry name" value="PEPTIDOGLYCAN-BINDING LYSIN DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042886550" description="LysM domain-containing protein" evidence="5">
        <location>
            <begin position="29"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="6">
        <location>
            <begin position="47"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="6">
        <location>
            <begin position="112"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="6">
        <location>
            <begin position="246"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="6">
        <location>
            <begin position="347"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="6">
        <location>
            <begin position="425"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="6">
        <location>
            <begin position="506"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="6">
        <location>
            <begin position="614"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="165"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="562"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="165"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="209"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="578"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4041141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="683" mass="73168" checksum="C843C3E635EAB56D" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PHZ8</accession>
    <name>A0AAN6PHZ8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_34752</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854361">
        <property type="protein sequence ID" value="KAK4041231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PHZ8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4041231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="171" mass="17785" checksum="F4C13CA1F7C8E976" modified="2024-10-02" version="1">MADHETSSTYIGAPGGPLALPPVAASNALGTSVLSCSPQSSAPPPYPTTPVPAKTRGTAPLPPSPGFFTRIKPGLSAANGRTRARQLVVFLVYLFSIVLLTIPLGLGLYPKVDRNVSAIAVLEVYLYVFMGLGVALALAVANCVARMTSPSRRSLGQREVELVDRTGLGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PI40</accession>
    <name>A0AAN6PI40_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_15143</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854364">
        <property type="protein sequence ID" value="KAK4041067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PI40"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14008">
        <property type="entry name" value="STKc_LKB1_CaMKK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000995">
        <property type="entry name" value="BcCMK3, calcium/calmodulin-dependent protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000447">
        <property type="entry name" value="Calcium/calmodulin dependent protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF77">
        <property type="entry name" value="SERINE THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="117"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="467"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="627"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="482"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="633"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4041067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="750" mass="80984" checksum="5EEE559A1FA58123" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PIN7</accession>
    <name>A0AAN6PIN7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ubiquitin-activating enzyme E1 1</fullName>
            <ecNumber evidence="6">6.2.1.45</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">C8A01DRAFT_45435</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + ubiquitin + [E1 ubiquitin-activating enzyme]-L-cysteine = AMP + diphosphate + S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine.</text>
            <dbReference type="EC" id="6.2.1.45"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the GST superfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the ubiquitin-activating E1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.45" evidence="6"/>
    <dbReference type="EMBL" id="MU854358">
        <property type="protein sequence ID" value="KAK4041367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031510">
        <property type="term" value="C:SUMO activating enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019948">
        <property type="term" value="F:SUMO activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004839">
        <property type="term" value="F:ubiquitin activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03190">
        <property type="entry name" value="GST_C_Omega_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01491">
        <property type="entry name" value="Ube1_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01490">
        <property type="entry name" value="Ube1_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000162">
        <property type="entry name" value="Glutathione S-transferase Gst3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2660:FF:000001">
        <property type="entry name" value="Ubiquitin-activating enzyme E1 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12550:FF:000001">
        <property type="entry name" value="Ubiquitin-activating enzyme E1 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000015">
        <property type="entry name" value="Ubiquitin-activating enzyme E1 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.60:FF:000001">
        <property type="entry name" value="Ubiquitin-activating enzyme E1 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.180:FF:000001">
        <property type="entry name" value="ubiquitin-like modifier-activating enzyme 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.80:FF:000001">
        <property type="entry name" value="ubiquitin-like modifier-activating enzyme 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.180">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, FCCH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.80">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12550">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2660">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, SCCH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.60">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, UFD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032420">
        <property type="entry name" value="E1_4HB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032418">
        <property type="entry name" value="E1_FCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042302">
        <property type="entry name" value="E1_FCCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047047">
        <property type="entry name" value="GST_Omega-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016639">
        <property type="entry name" value="GST_Omega/GSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018965">
        <property type="entry name" value="Ub-activating_enz_E1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042449">
        <property type="entry name" value="Ub-E1_IAD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038252">
        <property type="entry name" value="UBA_E1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019572">
        <property type="entry name" value="UBA_E1_SCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042063">
        <property type="entry name" value="Ubi_acti_E1_SCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018075">
        <property type="entry name" value="UBQ-activ_enz_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033127">
        <property type="entry name" value="UBQ-activ_enz_E1_Cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000011">
        <property type="entry name" value="UBQ/SUMO-activ_enz_E1-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01408">
        <property type="entry name" value="Ube1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF4">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16191">
        <property type="entry name" value="E1_4HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16190">
        <property type="entry name" value="E1_FCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09358">
        <property type="entry name" value="E1_UFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13410">
        <property type="entry name" value="GST_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10585">
        <property type="entry name" value="UBA_E1_SCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01849">
        <property type="entry name" value="UBIQUITINACT"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01206">
        <property type="entry name" value="Xi.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01148">
        <property type="entry name" value="Xi_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00985">
        <property type="entry name" value="UBA_e1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00865">
        <property type="entry name" value="UBIQUITIN_ACTIVAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="GST C-terminal" evidence="14">
        <location>
            <begin position="1227"/>
            <end position="1364"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="12">
        <location>
            <position position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00073786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK4041367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1395" mass="155796" checksum="BEFE65DA5F81A902" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PIN9</accession>
    <name>A0AAN6PIN9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_34546</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854357">
        <property type="protein sequence ID" value="KAK4041462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PIN9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF234">
        <property type="entry name" value="MFS-TYPE TRANSPORTER DBAD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="290"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="347"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="415"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4041462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="456" mass="48131" checksum="ED5C649E22174146" modified="2024-10-02" version="1">MATETTHPEQKPRSTISTMPSASDDAITAAPAAPEASQPAPFVPPDGGTRAWLTVAGGWLCQFCSFGFINALGSFQYVYEKEILPHESSSNITWILTTQLFLMFFLSQPVGLGVDMFGVRAILIPAFVFSVGGLIALSFATEYWQIFLAQSLCFGLGAAGAFIPGLVAAGQYFKKKRALAMGIVVSGSSVGGIVFPIMLARLFDQIGFRQTIRWAALMVGVMLALANLLVTAPVPPKGLAGRRSLISFATFKKPTYLLFVSGSFLFFWGLFGPFDYLPLFSSRDPSTDPIALYTVAILNAASIPGRILPNMYSDKVGSSLRTITACAFFAALSVLVIWLPINYHHSLGGLIVFVLVFGLTSGAFVSLMTPALIEVAGGHTTDLGVMVGTFFAIIALASLTGLPTQGAIAGDGGSLMGLIVFCGVVMLAGTGLVGCASWVSEREKRKAGEKAGNGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PIT0</accession>
    <name>A0AAN6PIT0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NCT transcriptional regulatory complex subunit A</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Negative cofactor 2 AB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_16140</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Forms the NCT transcriptional regulatory complex with nctB and mot1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NC2 alpha/DRAP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854388">
        <property type="protein sequence ID" value="KAK4039916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PIT0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017054">
        <property type="term" value="C:negative cofactor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001046">
        <property type="term" value="F:core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22906">
        <property type="entry name" value="HFD_DRAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000036">
        <property type="entry name" value="CBF/NF-Y family transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050568">
        <property type="entry name" value="Transcr_DNA_Rep_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252:SF5">
        <property type="entry name" value="DR1-ASSOCIATED COREPRESSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252">
        <property type="entry name" value="HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="8">
        <location>
            <begin position="270"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="348"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="131"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="160"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="201"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="357"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="392"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00061393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00065307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00072430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00075891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4039916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="409" mass="43064" checksum="027470E8650B7765" modified="2024-10-02" version="1">MSGDDTGTYAPKSPDLSSFYSAGPTPPAEPAEPQFLSQQSRPDFSRLQSPPRTYSIPNPQHQASAPQSPPPQAFAQARPANNPTVYQAPGFGGVGVGHPSIAQHEYYPPRAASYPMTGYSQPGTGYTATQAPPPQQQPPYYQPPYRGGSFQHQQYPPPQQQQQQQQQQQQTHQLQHELLAAQAQAQVRPPYDYPVPATEYASPPLQAQAQAQAQAQADAMPPRRAAAAAAAAVLAAQTGSNTEGDDGSSSPAAATAAAVASIEAATVKTKFPTARIKRIMQADEEVGKVAQQTPIAVGKALELFMVALVTKSAEVARQRNSKRVSAQMLKQVVEGDDQWDFLRDIVGKVEGEEKGGKGSGSQSQGGRGKAESSETDEEMGGGGGGGDAAAGAKKKRGGGRKKKVQGEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PIV2</accession>
    <name>A0AAN6PIV2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pro-apoptotic serine protease NMA111</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Pro-apoptotic serine protease nma111</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_35241</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Nuclear serine protease which mediates apoptosis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S1C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854370">
        <property type="protein sequence ID" value="KAK4040770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PIV2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06786">
        <property type="entry name" value="cpPDZ1_ScNma111-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06719">
        <property type="entry name" value="PDZ2-4_Nma111p-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.120">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025926">
        <property type="entry name" value="PDZ-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46366">
        <property type="entry name" value="PRO-APOPTOTIC SERINE PROTEASE NMA111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46366:SF8">
        <property type="entry name" value="PRO-APOPTOTIC SERINE PROTEASE NMA111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12812">
        <property type="entry name" value="PDZ_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13365">
        <property type="entry name" value="Trypsin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PDZ-like" evidence="8">
        <location>
            <begin position="396"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ-like" evidence="8">
        <location>
            <begin position="874"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4040770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1030" mass="113447" checksum="FC5A166E612BEF24" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PIZ3</accession>
    <name>A0AAN6PIZ3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ADP-ribosylation factor 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_16202</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854389">
        <property type="protein sequence ID" value="KAK4039869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PIZ3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04149">
        <property type="entry name" value="Arf6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000412">
        <property type="entry name" value="ADP-ribosylation factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041838">
        <property type="entry name" value="Arf6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="3 6 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="26"/>
            <end position="33"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="128"/>
            <end position="131"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4039869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="188" mass="21169" checksum="4858100D683D7182" modified="2024-10-02" version="1">MGASLSISSLFGKLFGSKEVRILMLGLDAAGKTTILYKLKLNQTMTTIPTVGFNVETFTYKNIKFNMWDVGGQDKIRPLWRHYYSGTQGLVFVVDSSDHNRIEEAKTELHRILNDLEMSDCLLLVFANKQDLDGAMDPQTITTRLELSKLKDRPWFVQPAIATEGEGLTEGFGWLSDNIKKMPKYGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PJ71</accession>
    <name>A0AAN6PJ71_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATP-dependent RNA helicase DHH1</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">ATP-dependent RNA helicase dhh1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">C8A01DRAFT_35905</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="MU854384">
        <property type="protein sequence ID" value="KAK4040126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PJ71"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17940">
        <property type="entry name" value="DEADc_DDX6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000114">
        <property type="entry name" value="ATP-dependent RNA helicase DDX6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000364">
        <property type="entry name" value="ATP-dependent RNA helicase DDX6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47960">
        <property type="entry name" value="DEAD-BOX ATP-DEPENDENT RNA HELICASE 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 17" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 17 22" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="5 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="21">
        <location>
            <begin position="47"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="19">
        <location>
            <begin position="78"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="20">
        <location>
            <begin position="258"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="427"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="16">
        <location>
            <begin position="47"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="440"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="18">
        <location>
            <begin position="476"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00040210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00040448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAK4040126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="534" mass="59312" checksum="2B53AAF8C28849F6" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PJC2</accession>
    <name>A0AAN6PJC2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_16417</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854396">
        <property type="protein sequence ID" value="KAK4039595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PJC2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF39">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042855159" description="FAD-binding PCMH-type domain-containing protein" evidence="6">
        <location>
            <begin position="22"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="7">
        <location>
            <begin position="144"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4039595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="425" mass="45837" checksum="A32AA9C8AFB87260" modified="2024-10-02" version="1">MRGAVFSSLCGALLLAQDVLAQQPVSVAGYSAPKWVLRRDGSSSYACKCYPGDYCWPNNGQFQKLNSTVGGNLRVNIPPGAPCYNTFKGPLGDVKTYDAAECAKVTANWYDEQWQIEQPAAGLWTYFTNDTCRPTTNPSDSCTLGYYPALVIMAKTTAHIQAGINFARDNNLRLIIRNTGHDFLGRSVGWGSLVINTHSFQDIKFTNAWRGACDYNGSAVTVGAGVQAFQVLKQANALNPPKVMVTGECGTVGVAGGLVQGGGHGPLTNFYGFLADTALEFKVITADGVLKTANAKINPDLFWALRGGGPAAFGVIVEATYKTFDDKPSSGVSFDLALSSNATLFWEAVRIFHGYSTHFVDNGLYRSTLPSALRRLVLSSHLHHRQPTTNHCRHHGRQHPAVCRHHGLDGLPMPASQPLLDALGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PJE3</accession>
    <name>A0AAN6PJE3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_14330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854348">
        <property type="protein sequence ID" value="KAK4041981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PJE3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4041981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="84" mass="9186" checksum="8BF2982136F2EF65" modified="2024-10-02" version="1">MDAQERATQTWTRLFVETAQSERQRREQHTADIQRSIQQYTAAAEHKIRAALGPEATTLLPSCTATPAVAAPAAPASRPMAKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PJL2</accession>
    <name>A0AAN6PJL2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">U three protein 23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_33849</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in rRNA-processing and ribosome biogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the UTP23/FCF1 family. UTP23 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854346">
        <property type="protein sequence ID" value="KAK4042086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PJL2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09865">
        <property type="entry name" value="PIN_ScUtp23p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000006">
        <property type="entry name" value="rRNA-processing protein UTP23 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006984">
        <property type="entry name" value="Fcf1/UTP23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057776">
        <property type="entry name" value="UTP23_sensor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12416">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN UTP23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04900">
        <property type="entry name" value="Fcf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24779">
        <property type="entry name" value="UTP23_sensor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="UTP23 sensor motif region" evidence="9">
        <location>
            <begin position="230"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="160"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="165"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="187"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="216"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00076388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4042086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="309" mass="34066" checksum="70BC11D880062D5B" modified="2024-10-02" version="1">MGKRTKQYKKLMRAFEHLGFRQPYQLLVTSDVLLDTTKLDLVSLFEKTLSTKGLKPMITQCCIRALYAKNVGPNRDQAVVAAIDRAKTFERRRCGHLMDADPLPERECMLSVVDPKGKGENKFRYVVVTQDELLRDTLRSVVPTPLMYVRRSVMILEPMSSSSARVREREERSKFLEGIVRRPQKRKREDDESGDEHSGSEGEGGEGDGDGGSNADRPRTAGGEDKPKKKKKQYGRKGPNPLAVRKAKTTSEAGQKPRKPAAPSAEASTETKTKRKRRKKASGAEGGGESGGAEQAGHADTAPVEAAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PJT8</accession>
    <name>A0AAN6PJT8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Box C/D snoRNA protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Zinc finger HIT domain-containing protein 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">C8A01DRAFT_46331</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for box C/D snoRNAs accumulation involved in snoRNA processing, snoRNA transport to the nucleolus and ribosome biogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with FBL, SNU13, NOP58, NUFIP1, RUVBL1, RUVBL2 and TAF9. Interacts (via HIT-type zinc finger) with the RUVBL1/RUVBL2 complex in the presence of ADP.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the BCD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854379">
        <property type="protein sequence ID" value="KAK4040349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PJT8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070761">
        <property type="term" value="C:pre-snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048254">
        <property type="term" value="P:snoRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23023">
        <property type="entry name" value="zf-HIT_BCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.190:FF:000001">
        <property type="entry name" value="box C/D snoRNA protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051639">
        <property type="entry name" value="BCD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057721">
        <property type="entry name" value="BCD1_alpha/beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007529">
        <property type="entry name" value="Znf_HIT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13483">
        <property type="entry name" value="BOX C_D SNORNA PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13483:SF11">
        <property type="entry name" value="ZINC FINGER HIT DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25790">
        <property type="entry name" value="BCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04438">
        <property type="entry name" value="zf-HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51083">
        <property type="entry name" value="ZF_HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HIT-type" evidence="16">
        <location>
            <begin position="10"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="224"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="373"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="72"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="227"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="243"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="260"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="275"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="385"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="397"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="471"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="509"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00061949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00068630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00077531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAK4040349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="538" mass="59664" checksum="16FB12B81EA6E019" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PKC8</accession>
    <name>A0AAN6PKC8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Thioredoxin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_44503</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Putative mitochondrial redox protein which could be involved in the reduction of small toxic molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FMP46 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854340">
        <property type="protein sequence ID" value="KAK4042491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PKC8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012882">
        <property type="entry name" value="Fmp46"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28071">
        <property type="entry name" value="REDOX PROTEIN FMP46, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28071:SF1">
        <property type="entry name" value="REDOX PROTEIN FMP46, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07955">
        <property type="entry name" value="DUF1687"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4042491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="142" mass="15821" checksum="F4165BF17BD38B8C" modified="2024-10-02" version="1">MFRFHKSLDIITLFHKATSPASVRLATALRQASAAASETSTEDQASDHTAQSNAVRRPEFKLEITETPPTADQLRTILDYVGKQRAGTIVEGATDEQEALRRYRENAERLQRPLVVDWNNGRAAAGENSESEILKMLNDLPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PKD5</accession>
    <name>A0AAN6PKD5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_33600</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854342">
        <property type="protein sequence ID" value="KAK4042392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PKD5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000196">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000012">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF198">
        <property type="entry name" value="AZOLE RESISTANCE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="271"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="407"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="442"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="521"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="51"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="552"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="564"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4042392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="583" mass="61672" checksum="C45CF30560EB3D84" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PKZ4</accession>
    <name>A0AAN6PKZ4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_15203</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854365">
        <property type="protein sequence ID" value="KAK4040994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PKZ4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="245"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="470"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="543"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="585"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="647"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="212"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="477"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="543"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="556"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="660"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="678"/>
            <end position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4040994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="705" mass="71909" checksum="79F58993B0A97C06" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PLP2</accession>
    <name>A0AAN6PLP2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Annexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_15376</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the annexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854369">
        <property type="protein sequence ID" value="KAK4040795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PLP2"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Annexin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001464">
        <property type="entry name" value="Annexin"/>
    </dbReference>
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        <property type="entry name" value="Annexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037104">
        <property type="entry name" value="Annexin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502">
        <property type="entry name" value="ANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502:SF102">
        <property type="entry name" value="ANNEXIN B11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00191">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00196">
        <property type="entry name" value="ANNEXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01871">
        <property type="entry name" value="ANNEXINVII"/>
    </dbReference>
    <dbReference type="SMART" id="SM00335">
        <property type="entry name" value="ANX"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47874">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51897">
        <property type="entry name" value="ANNEXIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0041">Annexin</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
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            <end position="31"/>
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    </feature>
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            <end position="43"/>
        </location>
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            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
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    </feature>
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    </feature>
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            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4040795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="530" mass="57259" checksum="312DCF22C786D4F5" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PM47</accession>
    <name>A0AAN6PM47_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase inhibitor I9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_34569</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protease inhibitor I9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854358">
        <property type="protein sequence ID" value="KAK4041371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PM47"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004866">
        <property type="term" value="F:endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.80:FF:000005">
        <property type="entry name" value="Proteinase inhibitor I2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="entry name" value="Peptidase S8 propeptide/proteinase inhibitor I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052471">
        <property type="entry name" value="PBI_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010259">
        <property type="entry name" value="S8pro/Inhibitor_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28288">
        <property type="entry name" value="PROTEASE B INHIBITOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28288:SF2">
        <property type="entry name" value="PROTEASE B INHIBITOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05922">
        <property type="entry name" value="Inhibitor_I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inhibitor I9" evidence="2">
        <location>
            <begin position="3"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4041371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="74" mass="8099" checksum="8D9809C1379650B2" modified="2024-10-02" version="1">MSSYIVTFKADATDAEVQEVKDDVVAKGGTVEHEYSLIKGFSFKTPEVSGFSVDTLSAHPNVETVEADQEMRTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PMQ0</accession>
    <name>A0AAN6PMQ0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SMODS and SLOG-associating 2TM effector domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_34065</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854349">
        <property type="protein sequence ID" value="KAK4041954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PMQ0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041622">
        <property type="entry name" value="SLATT_fungi"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF033635">
        <property type="entry name" value="SLATT_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38793">
        <property type="entry name" value="SLATT_FUNGAL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38793:SF1">
        <property type="entry name" value="SMODS AND SLOG-ASSOCIATING 2TM EFFECTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18142">
        <property type="entry name" value="SLATT_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="142"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="SMODS and SLOG-associating 2TM effector" evidence="3">
        <location>
            <begin position="129"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4041954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="278" mass="29795" checksum="88E07248036DB435" modified="2024-10-02" version="1">MASSSKGQTQQGLPPAHGGHPSDSTGSIYNLTADRRSSIPIPPSNSGNQPQPQPTPGAAPPLPSKPTPTGQPLPSSPSIQHRFLTPTEWARVAHGLGAIRDGGEEHQVVHPTSWLWAPRGLPDGLYRDVVFQRAKYALGFELLSTLHWFLMVVQVMIGAVLTALGSLPKREATLITTLAAVNTVGAGLIALMHNSGLPDRYRMDKAQFVQVEDFIREILDTGIVEAHQKVEDILNECFVRFAAARATVISNKPEVYSSPAATGGKNSAVLCREPSAHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PN24</accession>
    <name>A0AAN6PN24_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Histidinol dehydrogenase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_34452</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the histidinol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854356">
        <property type="protein sequence ID" value="KAK4041500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PN24"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004399">
        <property type="term" value="F:histidinol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06572">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1980:FF:000001">
        <property type="entry name" value="Histidinol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1980:FF:000026">
        <property type="entry name" value="Histidinol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1980">
        <property type="entry name" value="Nitrogenase molybdenum iron protein domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001692">
        <property type="entry name" value="Histidinol_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012131">
        <property type="entry name" value="Hstdl_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00069">
        <property type="entry name" value="hisD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21256:SF14">
        <property type="entry name" value="HISTIDINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21256">
        <property type="entry name" value="HISTIDINOL DEHYDROGENASE HDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00815">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00083">
        <property type="entry name" value="HOLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00611">
        <property type="entry name" value="HISOL_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4041500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="618" mass="64766" checksum="D3CA0B8E4FBA85AE" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PNC3</accession>
    <name>A0AAN6PNC3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">6-phosphogluconolactonase</fullName>
            <shortName evidence="6">6PGL</shortName>
            <ecNumber evidence="4 6">3.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_13271</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12556"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="3.1.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.31" evidence="4 6"/>
    <dbReference type="EMBL" id="MU854330">
        <property type="protein sequence ID" value="KAK4043200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PNC3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01400">
        <property type="entry name" value="6PGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1360:FF:000005">
        <property type="entry name" value="6-phosphogluconolactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005900">
        <property type="entry name" value="6-phosphogluconolactonase_DevB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039104">
        <property type="entry name" value="6PGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01198">
        <property type="entry name" value="pgl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11054">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11054:SF0">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucosamine/galactosamine-6-phosphate isomerase" evidence="7">
        <location>
            <begin position="14"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4043200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="261" mass="28194" checksum="B4AAD096CE29BDB3" modified="2024-10-02" version="1">MGQQANLYSFPAVDALATALRTYVIHCQTAGIARHGVFKVAVSGGSLPKTLAQALLSPPASDADVVHWGKWEIFFADERAVPLDHADSNYALLKAELLDKLPGGTAQPAVHPIDVEALDETQELADRYERTLVQSFASRDSVRLPIFDLLLLGCGPDGHTCSLFPGHELLRETDAWVAPIEDSPKPPPRRVTLTLPVVTHAVKVAFVATGGGKKEVMKEIFEEGNGLPCALVNEGCGDRCSWFVDNAAVEGVTYPRRPFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PP33</accession>
    <name>A0AAN6PP33_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ketopantoate reductase PanE/ApbA-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_31640</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854320">
        <property type="protein sequence ID" value="KAK4044322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PP33"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000017">
        <property type="entry name" value="2-dehydropantoate 2-reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000609">
        <property type="entry name" value="2-dehydropantoate 2-reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051402">
        <property type="entry name" value="KPR-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708:SF26">
        <property type="entry name" value="2-DEHYDROPANTOATE 2-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708">
        <property type="entry name" value="PROBABLE 2-DEHYDROPANTOATE 2-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketopantoate reductase N-terminal" evidence="2">
        <location>
            <begin position="19"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Ketopantoate reductase C-terminal" evidence="3">
        <location>
            <begin position="257"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="183"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4044322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="397" mass="42592" checksum="8F7AE40DB6C3C34F" modified="2024-10-02" version="1">MGGLEALTPGADPDRPVHIVFVGAGAVGCFYASRLHHPSHNIHVSLIARSNYKALAEHGVHLQTHTFGDYTFRPHAVFPSVAAAAANPSPSGAGPHEWDYIIVTTKALPDRSDDSALIAPLVGPNSCIVLIQNGVGVEQPYRARFPATPIISAVTVISAEQTSPGTVRQNRWTRIHLGPYSNSASFSSESTTATTYPRGDDTTGALTPTGSSPNNHPTPDPTTLQQTGTHRAALLTDWWTRLGQIRDVDLAADEIALQTIRWHKLCINAAFNPSAVLSGGLGNADMVRDAELRAHLAGVMREIWEAVPKILGRGFPGYMATPEKILKSTERNVGSKPSMLLDWEGGRPMEVEVILGNPVRIARARGVEMPRLQSVYALVRSLQAVRDSKGGRAGGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PPF8</accession>
    <name>A0AAN6PPF8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb-like DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_12887</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854326">
        <property type="protein sequence ID" value="KAK4043588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PPF8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054505">
        <property type="entry name" value="Myb_DNA-bind_8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22980">
        <property type="entry name" value="Myb_DNA-bind_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like DNA-binding" evidence="2">
        <location>
            <begin position="7"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4043588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="302" mass="32184" checksum="30BEF32BFDBC6FD4" modified="2024-10-02" version="1">MPAIDTEAQFKFLLCCIKHSAAGKVNFDNVAQELQIVSKAAAAKRYERLLKAHNITLATARKGGAAANADAAEDSGEPKTPASKKRKRATASTAKKDEDEETPVKKERGVKKERALKKEDSDSDVRVKGEDGSFINNTTTTITAAAPCCVGGVIKSDLPEASPRRQDPDGHRPGGADADDDYCVVVSERPVILPSPVSVPVPVPVDYAAHGHGHGPSHGALLTPPDFGYHHHHHDHHHAVHCHDANLAFPLQTMSTSRSNSALEASTAGDATPSSQHFGNWSISQTSAPPSEFYCGGHHLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PPM7</accession>
    <name>A0AAN6PPM7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_43280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854323">
        <property type="protein sequence ID" value="KAK4043920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PPM7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13668">
        <property type="entry name" value="Ferritin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042904678" evidence="1">
        <location>
            <begin position="27"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4043920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="400" mass="43017" checksum="D16700EA0CB8DB0C" modified="2024-10-02" version="1">MRPTQSLSPVLAAVAVLLVGNQQVRAEPFSFPLANGFPFPNQTALEELFTRAGGNFTNAPLAPRFDDDSLTSWKLQAFNEFMEVAFFTQLIANITNGVAGYEIDSSTREYVLTSLETIQAQEEMHAYNANDAVRYFTNGSHMFPCTYQFPVSTFAEAVDFAQTLTDMYIGLLANIQQRTALHLGSDSNSIIYVLAQALGQEGQQSGWFRSLRRIPPSAEPFLTTSTREFALGWMQHWIVPGSCPNMDAIPLRILPPLTITAVSIGDASHSGNVTLVAPGALDPDSQSVAFVNGALVPTVVPFKVRQTSPCGGDDRAAATDRVTTTQHDQTVLASGRATSAGPGGSEGCIASTEITADMPYAHNVMHGLVLMAVVENSGEFITAQDVADATLYGPALLEWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PPR4</accession>
    <name>A0AAN6PPR4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_32949</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
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    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">CBS 284.82</strain>
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    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
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                <person name="Haridas S."/>
                <person name="Kuo A."/>
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                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
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                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
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                <person name="Natvig D.O."/>
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                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
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                <person name="Grigoriev I.V."/>
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                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </evidence>
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        <source>
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Brannstrom I.O."/>
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                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
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                <person name="Steindorff A."/>
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                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
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                <person name="Powell A.J."/>
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                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
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                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
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    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08839">
        <property type="entry name" value="ArfGap_SMAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000010">
        <property type="entry name" value="Stromal membrane-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051718">
        <property type="entry name" value="ARF_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044732">
        <property type="entry name" value="ArfGAP_SMAP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45705">
        <property type="entry name" value="FI20236P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45705:SF1">
        <property type="entry name" value="FI20236P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="3">
        <location>
            <begin position="17"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="190"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="266"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="526"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="239"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="307"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="325"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="367"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="379"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="405"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="432"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="527"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4043126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="557" mass="56919" checksum="A1775DEAA5E163D8" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PQM4</accession>
    <name>A0AAN6PQM4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutamine synthetase</fullName>
            <ecNumber evidence="3">6.3.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Glutamate--ammonia ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">C8A01DRAFT_31795</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-glutamate + NH4(+) + ATP = L-glutamine + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16169"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.1.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homooctamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10 11">Belongs to the glutamine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.2" evidence="3"/>
    <dbReference type="EMBL" id="MU854321">
        <property type="protein sequence ID" value="KAK4044188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PQM4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamine synthetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.70:FF:000004">
        <property type="entry name" value="Glutamine synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.10:FF:000004">
        <property type="entry name" value="Glutamine synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.10">
        <property type="entry name" value="Glutamine synthetase/guanido kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008147">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027302">
        <property type="entry name" value="Gln_synth_N_conserv_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050292">
        <property type="entry name" value="Glutamine_Synthetase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20852">
        <property type="entry name" value="GLUTAMINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20852:SF57">
        <property type="entry name" value="GLUTAMINE SYNTHETASE 2 CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03951">
        <property type="entry name" value="Gln-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00180">
        <property type="entry name" value="GLNA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51986">
        <property type="entry name" value="GS_BETA_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51987">
        <property type="entry name" value="GS_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GS beta-grasp" evidence="12">
        <location>
            <begin position="26"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="GS catalytic" evidence="13">
        <location>
            <begin position="116"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK4044188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="359" mass="39867" checksum="26B08BD62AFDFF96" modified="2024-10-02" version="1">MATTEASISRSEIVNNYTTLDQKGIVIAEYVWIDAEGNSRSKTRTLEPRDDGKQWDVDTLPIWNFDGSSTGQAPGENSDVYLRPCAVYPDPFRKGNNILVLTECWNHDGTPNKYNYRHECAKLMQAHAETVPWFGLEQEYTLLDLSDRPYGWPQNGFPAPQGPYYCGVGAGRVVQRDIVESHLRACIYAGVKISGTNAEVSKSQWEFQVGPCVGISMGDDLWIARYILARVAEDFGVKVSLHPKLIPGDWNGAGMHSNFSTQEMREEGGMKAIEAAIKKLEGRHMEHIAVYGEDNEKRLTGRHETGAIDSGVANRGASIRIPREVAAKGCGYFEDRRPASNADPYRVTGILMETIYGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PSX2</accession>
    <name>A0AAN6PSX2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HNH nuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_31227</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854317">
        <property type="protein sequence ID" value="KAK4044729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PSX2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13391">
        <property type="entry name" value="HNH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNH nuclease" evidence="2">
        <location>
            <begin position="107"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="373"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4044729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="421" mass="46301" checksum="7E9F49DE3912381B" modified="2024-10-02" version="1">MQLQQAFTPPQRPIDGNSKLIHFRHPAYPDTEPDLLCLSALDGGGDGIDYDLALTSCVPGGPVFRPLAIPARHLPSPWKDLRLDSYATYPDAHLKSKVAALARDGTCRISGYCDAVEAAHLVPLADGHWFRSNSMERYCCLPAEPHPINDERNLVILRGDLHHLLDTRRFTFVAKSVATQPLSPHSPTVQLALHVMLPSRSDQLPSLYHNRALQHPVRGLAVEFLFARFAWTLFTDENMPFLNGFAKHSVLLFDPSEGRVDEETLRSAEVRKHAKLFESYSCSRSVSPRKRPLSSQPSSSQPRPPQTDAEAFETGSCGVPPFDLAASSDDGDEDWDAGDGGESSEEQWTRGRRRKRSFGTLERDDYDPPSLGASFVSASDASVATVPGELSPQEAPSSKGPASDEPPKLCSKRPRRNVFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SKM4</accession>
    <name>A0AAN6SKM4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Altered inheritance of mitochondria protein 24, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_20980</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the AIM24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854687">
        <property type="protein sequence ID" value="KAK4031871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SKM4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007007">
        <property type="term" value="P:inner mitochondrial membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.160.10:FF:000001">
        <property type="entry name" value="Altered inheritance of mitochondria protein 24, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.160.10">
        <property type="entry name" value="Mitochondrial biogenesis AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002838">
        <property type="entry name" value="AIM24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036983">
        <property type="entry name" value="AIM24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016031">
        <property type="entry name" value="Trp_RNA-bd_attenuator-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36959">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 24, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36959:SF2">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 24, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01987">
        <property type="entry name" value="AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51219">
        <property type="entry name" value="TRAP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4031871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="390" mass="42370" checksum="D530EBF27632470C" modified="2024-10-02" version="1">MRRQAPLVRRLRPAALTRPPTRPGFVCWQCRAIQISASPTTDSRPAADAFGAYPGSQRDSADARFEVLGSPYSLISVSLSASQRLYTRRGTLVSVAGKVENAQSTLSLLSPLRRAPLGIPFLYQRISSTTPITALIATKSPNTSFSVLHLDGTTDWIVAQRNALLAWTGHTLAPSPRVQQGMAVAHWGNTHLTGRGLAALAAPGQVYELTLGEGEEMVLHPSHVVAYPVTRNPPLPFRFRSTRLGLQVPAVPASITAAVGRLVPGRVARFWNAMRDTGTYKAVARLLYGLRTATRRTIWGDSLFLQFKGPMTVLMSTRGARVRDVLSREDVNEIADAEAGVVPAAVQLATKPKVVEEKRPEEKVAIHVASVGRDGKVSFEDAKDLNDFVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SKN2</accession>
    <name>A0AAN6SKN2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_41663</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854682">
        <property type="protein sequence ID" value="KAK4031901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SKN2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39596">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39596:SF2">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G17550)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="919"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="957"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1015"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="328"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1035"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4031901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1035" mass="114868" checksum="1A15DA38B8000F7C" modified="2024-10-02" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SLS5</accession>
    <name>A0AAN6SLS5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_20854</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854661">
        <property type="protein sequence ID" value="KAK4032022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SLS5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4032022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="55" mass="6192" checksum="12FB6FDF7B3D5CA1" modified="2024-10-02" version="1" fragment="single">YEELYNARQSLNILVDGIADGADDAARRRPKSFFHDFCVMMGPNESAKILAPETF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SM01</accession>
    <name>A0AAN6SM01_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_20367</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the secreted LysM effector family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854596">
        <property type="protein sequence ID" value="KAK4032564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SM01"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052210">
        <property type="entry name" value="LysM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997">
        <property type="entry name" value="AM15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997:SF1">
        <property type="entry name" value="PEPTIDOGLYCAN-BINDING LYSIN DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="LysM" evidence="4">
        <location>
            <begin position="219"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4032564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="437" mass="46250" checksum="E445897C2F8F1266" modified="2024-10-02" version="1">MFLSLQATVSAQTFADYPLSNVWPGISPACLTALNTTVDCSWLLAESAENQQPRLNAGDLTALCTPSCLPSLNNAKATIQAACTLATDAITLDTGTYPATYLVDLVVDPVHRTAQEYCDVLFAQWLNQPSLSAAQGRDRDCSDCMLGVVQLQLNSPFGYDADFASEFVSLTSSCSKTGYAFTSPPPYTVSATGMAIATGTSSSSPSASPTDVLEPGCVSLYTIQAGDTCNSIALAQNVSTFAVYGSHGITDCSNLPAGSKLCLLGQCLLHQVHETDTCDSIIAGASITVSPSMFVAWNPNIDAVCSNLHRLVGMYICLSRPVGLLTPNITVPDATAPATATAWPTIYPPDETQLPMAPGTLTGCQRYVNYRDVAIQDSFYQPEAVLFTEMGNHCTFVAMDNDILLDDLLSWNPSLNEANCALAAGYSYCVSSSNSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SMI3</accession>
    <name>A0AAN6SMI3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CorA-like transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_40957</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854592">
        <property type="protein sequence ID" value="KAK4032595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SMI3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058257">
        <property type="entry name" value="CorA-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26616">
        <property type="entry name" value="CorA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CorA-like transporter" evidence="2">
        <location>
            <begin position="33"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="440"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4032595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="465" mass="52510" checksum="5A87F1C10C6C4253" modified="2024-10-02" version="1">MNIQDLLCEPTVSPAAVALGPTNPPAVETKTRRNFEEYPRAAALDWELMPHEADEAEEHFQRLQMEQTRLFSNSHHMIDVLESSSDAAVDEPRKYSFTNVDKLEEHLLSRDKALIRHVFIEADDSPSPLNCSVSMLKCVLAYEQVPPAFLKAVYAFGDRPGDLADAGLASFGRHSRTYRGHTEASENVHLSCEWYLVRSFEKRQGDVMHSRDWPWLPRQMAVYHSFNHENGRSFFLTIRGNGLFRKQIQARRSLLASPPVKGPHAQREAALQTALTTHLMYLSWCCRHWGQFIDDVRTMVWEFLIPTRTRPRALDREPEEVGTPGLGAILTKITFRDLQNMNGHADYLRNALLNLTETGRIVRSMTCVPFSWARTPASTGSKASISRFSCELQSFAATIEVAEDQLRALAAELGQGIELHKKGLDLRVWHEQQQLENKGHSILQKSPIKAEDAEPGLASVDDSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SN66</accession>
    <name>A0AAN6SN66_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_40243</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854539">
        <property type="protein sequence ID" value="KAK4033300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SN66"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4033300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="350" mass="38099" checksum="D28134BDDD1E5AF3" modified="2024-10-02" version="1">MFVDHPFSEQHRKRLREDEEDASSGSPVGFTEHRSKRLQSLPLRTSPNSRRWIVRPSFSLPNPTFATTAQGQAVTPQEPMQEHVWADEPELVSIATSGPDHDMDMMDMSEPASGCDQPGLQRQHNIQQDSFPVDQSEPSVTGRIPTPIHCSFAVQVRGNNWNGGSAMHGPGDILATTPEEPNAAAFSSNGLVDLSSHKFAAAAMADWSMVQNRRLPSPISECGAEESHGSSARMALDSSSLHGGHHHLSHLTHEHPLVAGLPPRASSAMEARSAREATPAAEHQYGGCAMDVESPATPSPKKGHTRSKHTVNSWTALQPGMTRSFSIGYRADCERCRNKVPGHFNHIIIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SNE2</accession>
    <name>A0AAN6SNE2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6604 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_49810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854517">
        <property type="protein sequence ID" value="KAK4033658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SNE2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046539">
        <property type="entry name" value="DUF6604"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38795">
        <property type="entry name" value="DUF6604 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38795:SF1">
        <property type="entry name" value="DUF6604 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20253">
        <property type="entry name" value="DUF6604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6604" evidence="2">
        <location>
            <begin position="5"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4033658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="863" mass="97211" checksum="DB50FAEEF0DB478D" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SNQ0</accession>
    <name>A0AAN6SNQ0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ABC1 family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_19176</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854501">
        <property type="protein sequence ID" value="KAK4033958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SNQ0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13969">
        <property type="entry name" value="ADCK1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045307">
        <property type="entry name" value="ADCK1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051130">
        <property type="entry name" value="Mito_struct-func_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173:SF19">
        <property type="entry name" value="AARF DOMAIN-CONTAINING PROTEIN KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173">
        <property type="entry name" value="ABC1 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="3">
        <location>
            <begin position="172"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="27"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4033958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="589" mass="66315" checksum="18DBA72A96E85861" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SP83</accession>
    <name>A0AAN6SP83_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_18743</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854479">
        <property type="protein sequence ID" value="KAK4034455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SP83"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050889">
        <property type="entry name" value="Dendritic_Spine_Reg/Scaffold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24166:SF48">
        <property type="entry name" value="PROTEIN VAPYRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24166">
        <property type="entry name" value="ROLLING PEBBLES, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="32"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4034455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="256" mass="27602" checksum="D74EEB66DBF79156" modified="2024-10-02" version="1" fragment="single">TPLLHAAIAGQVQQVDYLCQKGANVDFQLRTSGETALHFAVLGQSFSVVQALLQHGAQFLPDGKGRKPLILAYTTGNQGIIRALQQADTGFMLRHAPRATPSPMQETSSEQSPPGLAHALQAGIVSGNLEFCQQLHASGCHLDVDLECGGCSPLILATRCEEFDIVKWLLESGASSTKVSCTLHGDALLYKTPLELLLSQSTKVGTELIQLFIDKFRGEGGDIFQGHLVFLAAESNNTTALGLLLEQREWLATRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SQ17</accession>
    <name>A0AAN6SQ17_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_48436</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854447">
        <property type="protein sequence ID" value="KAK4035340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SQ17"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107:SF16">
        <property type="entry name" value="NADPH-DEPENDENT ALDEHYDE REDUCTASE 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107">
        <property type="entry name" value="NADPH-DEPENDENT ALDEHYDE REDUCTASE-LIKE PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042842223" evidence="3">
        <location>
            <begin position="27"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4035340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="317" mass="33931" checksum="B36FB245A9885E16" modified="2024-10-02" version="1">MDRKARRRLLASFLFTASLLVGAVSAWSSKDSSRMYTLCRLKPVDHSGSHVPSLVDPRTRYQERVILPDKGFPGLHRNWDPPIDSGEESYISSGRFKGRKTLITGGDSGVGRAVAIAHAREGADVTISYLPEEQPDADKVKALVEAEGVRFFAMSGNLRNETFCTCLVHQAHEAMGGLDILVSNAGYWTFEDNVFASFYLVRAPAPLLPPGFSIIFTPRARRGGLTAALVSMAQALVLQLGPQGIRVNAVAPGPTATNFLTSHGLTTENADTIVSQLPLGRIAQPAEIAPAYVMLVEGSGSQSIASAYGINGGSLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SQF2</accession>
    <name>A0AAN6SQF2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7136 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_17577</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854432">
        <property type="protein sequence ID" value="KAK4038346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SQF2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055560">
        <property type="entry name" value="DUF7136"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23584">
        <property type="entry name" value="DUF7136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042912437" description="DUF7136 domain-containing protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7136" evidence="2">
        <location>
            <begin position="34"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4038346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="282" mass="30051" checksum="C542970045668BE2" modified="2024-10-02" version="1">MALHRSFVVLLLLAVLYYPTPTVAQGQNITVSYPVTVEFDLVFPRNDTYAPAPVFPVVFAVQNLPEAAVSSSLYLDWYLTRAQGEYLETGRVDFDRVNASSNPYFVVGWTGKINSTESADTYTLLWSFRHPNCSLGMFGSATDFDSSEYQDFITFTVAAGGKQPDFAADRDTCPTRHATFEQTGTLPAAGTTWNNYNSARDVCGVLATSPPPANPCAAKINDAAASSILAELTTSACAHSPPALSSGCPPPTDTSVGTRAQVGRAGADLGLLLAGVTMLVQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SQF7</accession>
    <name>A0AAN6SQF7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_47938</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854428">
        <property type="protein sequence ID" value="KAK4038480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SQF7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF65">
        <property type="entry name" value="MAGNESIUM TRANSPORTER NIPA9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="263"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="288"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="388"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="73"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="430"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="561"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="107"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="120"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="144"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="452"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="575"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="591"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="603"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4038480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="672" mass="72011" checksum="4A7131BBC0C60DC3" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SR53</accession>
    <name>A0AAN6SR53_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_46586</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854386">
        <property type="protein sequence ID" value="KAK4040009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SR53"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008526">
        <property type="term" value="F:phosphatidylinositol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.525.10:FF:000013">
        <property type="entry name" value="Phosphatidylinositol transfer protein PDR16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052578">
        <property type="entry name" value="PI_Transfer_CRAL-TRIO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45824">
        <property type="entry name" value="GH16843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45824:SF29">
        <property type="entry name" value="GH16843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="121"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="325"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4040009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="645" mass="72035" checksum="DF94ED2980CD550A" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SRA2</accession>
    <name>A0AAN6SRA2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sucrase/ferredoxin-like-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_16747</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854406">
        <property type="protein sequence ID" value="KAK4039246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SRA2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03062">
        <property type="entry name" value="TRX_Fd_Sucrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009737">
        <property type="entry name" value="Aim32/Apd1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31902">
        <property type="entry name" value="ACTIN PATCHES DISTAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31902:SF14">
        <property type="entry name" value="ACTIN PATCHES DISTAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06999">
        <property type="entry name" value="Suc_Fer-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4039246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="353" mass="38087" checksum="F37930418D51CAD5" modified="2024-10-02" version="1">MAGAFKSLINSAKAFAMGNSGSKAELHDLFPAVDKAVDGDDCDRDCGSCSVQYPKGFKIDEGDDLYGFVKGWSTHVLVATGKTDWVRDVGDEKGSVMQAIAGAKGPTNGRLLLSASNIPTPHHTTSYSEPTTVLLLPAFTLIENVTPATVPTLITSIISHAPTTTTPLQPFSLPRSLPAPLPEGTPAAIKDLTTRACPHRALILLCSQKTRDARCGQSAPLLRREFQRHLQPLGLYRDLDDERPGGVGIYFISHVGGHKYSANVMVYRRGEDTKEGGEGKETMEGQEGGEGEEKEGEEEEEGDVGAAQCIWLARVRPEDCEGIVKFTVLQGKVVKPERQLRGGFDRGKGLLSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SRX1</accession>
    <name>A0AAN6SRX1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_36102</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854389">
        <property type="protein sequence ID" value="KAK4039876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SRX1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="734"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="861"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="734"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="791"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="892"/>
            <end position="901"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4039876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="934" mass="102888" checksum="F0D3D5AEC50B8C38" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SS88</accession>
    <name>A0AAN6SS88_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Membrane bound O-acyl transferase family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_15675</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the wax synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854377">
        <property type="protein sequence ID" value="KAK4040415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SS88"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044851">
        <property type="entry name" value="Wax_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032805">
        <property type="entry name" value="Wax_synthase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31595">
        <property type="entry name" value="LONG-CHAIN-ALCOHOL O-FATTY-ACYLTRANSFERASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31595:SF67">
        <property type="entry name" value="WAX SYNTHASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13813">
        <property type="entry name" value="MBOAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Wax synthase" evidence="8">
        <location>
            <begin position="106"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4040415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="259" mass="29696" checksum="B5608CCFA2A571BA" modified="2024-10-02" version="1">MAPNQTNKDRLLFAALRGTRAITFWVLDRLVSHLVTDTFLRLSIRLSDFEPAHQGLLPCLTRRDLSLRAIMTVQWIWSMYSKLTMVHDLLALIFVALLGWDQPLEWPPVFGNLLEAYSLRRFWGIFWHRLHVALFDAYIPSFPCRREAGQQRDTNRFGVDASKALRPLCIFLFSAICHSVVNSAVLGRSSVLPEARFFLSNYVLCLLETLLKHLFNGKGLSNCSRLKRPLGYVWVLVVFFALTPGWQYPSIYGYGGGDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SSR0</accession>
    <name>A0AAN6SSR0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_34143</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854351">
        <property type="protein sequence ID" value="KAK4041764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SSR0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="72"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4041764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="83" mass="9044" checksum="360C85E9BE883D86" modified="2024-10-02" version="1">MSPTYTMSAHLCKQIYSSWRQAHPQPSPDPSPLPSPPTAFSSSSNNTASYLSRPSSPTAEKRSMDSDRGEPSSSGGNWRWGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SST4</accession>
    <name>A0AAN6SST4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_35200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854370">
        <property type="protein sequence ID" value="KAK4040733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SST4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4040733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="56" mass="6548" checksum="F29C5BE6D7379E02" modified="2024-10-02" version="1">MALASHSHCAHSFVMIKSDNTLIEWTCHVCHSGPFWFIWECRYCRLHTCRSCMDSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6ST29</accession>
    <name>A0AAN6ST29_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_45745</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. MAK3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854365">
        <property type="protein sequence ID" value="KAK4041018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6ST29"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031417">
        <property type="term" value="C:NatC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004596">
        <property type="term" value="F:protein-N-terminal amino-acid acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044542">
        <property type="entry name" value="NAA30-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45896">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45896:SF1">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="28"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4041018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="202" mass="22708" checksum="0AE15D0CC6EB1699" modified="2024-10-02" version="1">MASPSDNSSSDVDSTTPKAELPGELQYIQYQHSLESQYLPAIRALISKDLSEPYSIYVYRYFLCQWGHLCFMALNPTDSSLIGVVICKLEMHSSHCTPTLRGYIAMLAVSAQYRGHGVATALVKMAIDAMTKRNADEIVLETEETNIPAMRLYERLGFLRSKKLHRYYLNGNSAYRLVLLLKSIDMDAATDLALDEEDSALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6STF7</accession>
    <name>A0AAN6STF7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_14775</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854356">
        <property type="protein sequence ID" value="KAK4041496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6STF7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="3"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4041496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="252" mass="27817" checksum="9442DDCDE0997ABA" modified="2024-10-02" version="1" fragment="single">QALYASILSYNLANNVIKMSFLLQYRRIFGSSSPTADRVCNWLFFFVLLWAVVQAVLLGLCCIPVATVVPSMAGKCLDTLPVWYTSSVMNIVTDFITFLVPLPCVYNMTLRTKQKILVLSIFSLGFFTCIISIIRLVYLQVVTSTEDLTWDYVELTLWSVAELNCGILCASLQTLRPLLSKFIPGLAFSGSNEGRVRGGLFRDVNNGILLEESPRPSPASTDASTSTTGCPIAPVLTRGGERNCRASRHVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SUC6</accession>
    <name>A0AAN6SUC6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HIG1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_33394</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854339">
        <property type="protein sequence ID" value="KAK4042590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SUC6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007667">
        <property type="entry name" value="Hypoxia_induced_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040153">
        <property type="entry name" value="Rcf2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28018">
        <property type="entry name" value="RESPIRATORY SUPERCOMPLEX FACTOR 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28018:SF3">
        <property type="entry name" value="RESPIRATORY SUPERCOMPLEX FACTOR 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04588">
        <property type="entry name" value="HIG_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51503">
        <property type="entry name" value="HIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="HIG1" evidence="7">
        <location>
            <begin position="89"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="223"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4042590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="244" mass="27231" checksum="1A7C204E369BD887" modified="2024-10-02" version="1">MKIISKEVEQEHYGVVIRGGLLGGTAGLALGLAGVIGGARRYPVIRQLTLPFRSFIVTSTGTFGAIVVAERYSINYQRSHDAMNNYMEASHRAAEEARRAHQTDYQRFLAWGRENRYSIVFASWIAAMGLALAMVGRNKYLSTSQKLVQARVYAQGLTLAVLIATAAFETADAKAGKGRWETVMVVDPDDPTQQHMIEKKIHKEDYEGQDLWKEMVAAEEKRLGQQKKQREAVQKTQENKAAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SUI6</accession>
    <name>A0AAN6SUI6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CoA-transferase family III domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_13369</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoA-transferase III family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854332">
        <property type="protein sequence ID" value="KAK4043072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SUI6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="entry name" value="Crotonobetainyl-coa:carnitine coa-transferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="entry name" value="formyl-coa transferase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050509">
        <property type="entry name" value="CoA-transferase_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48228:SF5">
        <property type="entry name" value="ALPHA-METHYLACYL-COA RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48228">
        <property type="entry name" value="SUCCINYL-COA--D-CITRAMALATE COA-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="CoA-transferase family III (CaiB/BaiF)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="346"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="353"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4043072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="404" mass="43667" checksum="EACEF581402BB1F3" modified="2024-10-02" version="1">MPSQPPLTGLKVLELAGLAPGPFAGLLLADAGASVLRIDRPSSPSSAPSSPATDLLTRNKTSIALDLKNPRGAALLLSLAREADVLIDPYRPGVLEALGLGPSVLCRLNPRLVYARLTGFRRDASSSRFSAMAGHDINYLAVSGVLALLGRKGQPPTPPGNLLGDFAGGGVMLVLGVLMALLVRERSGRGQVVEGNMVDGVGYLGSFARFALKTPAWDRERGENLLDSGCPWYECYETKDGKWMAVGALEERFFGELVRGLGLAGQGWEEGRRYDRGQWPELRRVLEEAFGGKTRDEWERVFAGTDACCTPVYEYGEMERDRGKEGDQRPAVTLRETPWLAVRKDAENASHGQGPGVEGEGYVGRPLEPGHGGEETLKEWLGWSKGKQFDVEEGGLVLKEKPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SUN4</accession>
    <name>A0AAN6SUN4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Vacuolar protein sorting 55</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_44106</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OB-RGRP/VPS55 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854334">
        <property type="protein sequence ID" value="KAK4042890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SUN4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034424">
        <property type="term" value="C:Vps55/Vps68 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007262">
        <property type="entry name" value="Vps55/LEPROT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12050">
        <property type="entry name" value="LEPTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12050:SF0">
        <property type="entry name" value="RH04491P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04133">
        <property type="entry name" value="Vps55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="9"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4042890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="129" mass="13828" checksum="C03C0B2EF6F3BE0A" modified="2024-10-02" version="1">MPTAGLKTIIALSFVLAVGFLLVILSCALWHSYYPLLVVATYVLAPVPNWICSHCANPDDFVESSGAAVLDLGRFCTGFLVVMGVALPVLLAHSSLISIPAMVMSVIGGLLIYGTIISFAMFFQEEQEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SUX9</accession>
    <name>A0AAN6SUX9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alcohol dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_43485</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.1" evidence="3"/>
    <dbReference type="EMBL" id="MU854326">
        <property type="protein sequence ID" value="KAK4043537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SUX9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08297">
        <property type="entry name" value="CAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000039">
        <property type="entry name" value="Alcohol dehydrogenase AdhP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.180.10:FF:000002">
        <property type="entry name" value="Alcohol dehydrogenase AdhP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF3">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Rhodanese" evidence="9">
        <location>
            <begin position="166"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4043537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="353" mass="37274" checksum="6D8EEEA96F217E4D" modified="2024-10-02" version="1">MASFEIPSEQWAQVVEKSGGPVSYKKIPVQQPGPDEVLINVKYSGVCHTDLHAMMGDWPIPTKLPLVGGHEGAGVVVAKGDLVTDLALGDHAGIKWLNGSCLACSFCMQADEPLCPRALLSGYTVDGTFQQYAVAKAAHVARIPKDCDLEAVAPVLCAGITVYKGLKESGARPGQTVAIVGAGGGLGCMAVQYARAMGLHVVGIDGGAEKGESCKALGAAAYVDYMSSADLVQEVKAATPEGLGPHAVLLLAVSERPFQQATEYVRSRGSVVCIGLPAGAFFKAPVFDTVIRMITIKGSYVGNRQDTQEALDFFQRGLVTVPFKTVGLSELQDVYQLMREGKIVGRYVVDTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SV49</accession>
    <name>A0AAN6SV49_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2'-phosphotransferase</fullName>
            <ecNumber evidence="3">2.7.1.160</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_32683</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2'-phosphate from ligated tRNA to NAD to produce ADP-ribose 1''-2'' cyclic phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2'-phospho-[ligated tRNA] + NAD(+) = mature tRNA + ADP-alpha-D-ribose 1'',2''-cyclic phosphate + nicotinamide</text>
            <dbReference type="Rhea" id="RHEA:23324"/>
            <dbReference type="Rhea" id="RHEA-COMP:11106"/>
            <dbReference type="Rhea" id="RHEA-COMP:11107"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:76596"/>
            <dbReference type="ChEBI" id="CHEBI:82883"/>
            <dbReference type="ChEBI" id="CHEBI:85027"/>
            <dbReference type="EC" id="2.7.1.160"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the KptA/TPT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.160" evidence="3"/>
    <dbReference type="EMBL" id="MU854330">
        <property type="protein sequence ID" value="KAK4043193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SV49"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000215">
        <property type="term" value="F:tRNA 2'-phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.170.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.970">
        <property type="entry name" value="RNA 2'-phosphotransferase, Tpt1/KptA family, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002745">
        <property type="entry name" value="Ptrans_KptA/Tpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042081">
        <property type="entry name" value="RNA_2'-PTrans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042080">
        <property type="entry name" value="RNA_2'-PTrans_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12684">
        <property type="entry name" value="PUTATIVE PHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12684:SF2">
        <property type="entry name" value="TRNA 2'-PHOSPHOTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01885">
        <property type="entry name" value="PTS_2-RNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="302"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="29"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4043193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="328" mass="34514" checksum="96812ADFEB4726F3" modified="2024-10-02" version="1">MADPTTDANDDALADRLEDMTVAASSRHSGGGGRRGGGKGGGKGGGGGRSGGEGGRGRREVDLSRALSRLLRHQAGSAGVEIDREGFAGLERVLQWGPLRALAPTFPEILNAVHNSDKQRFAMKPNPATNPALDESSTDPAHWLIRANQGHSIKLDSEHLLKPLALPSEEEGGDGTLPEGTVPIPPAVIHGTYFAFWPAIVASGGLKPMGRNHVHFSTGLPEDAQAGVISGMRQDAEVLIYVDVAASMREGGIKWWMSDNGVVLTEGGADGLVPLKYFKEVVGRRQEVGLLWKDGEKVADLPEGLKVRAPQGKRGGGGRGGRGRGQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SVB8</accession>
    <name>A0AAN6SVB8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_43549</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854326">
        <property type="protein sequence ID" value="KAK4043610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SVB8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050052">
        <property type="entry name" value="ATP-dep_Clp_protease_ClpX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48102:SF7">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE ATP-BINDING SUBUNIT CLPX-LIKE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48102">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE ATP-BINDING SUBUNIT CLPX-LIKE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="4">
        <location>
            <begin position="192"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="Clp ATPase C-terminal" evidence="5">
        <location>
            <begin position="449"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="304"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="557"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="313"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="561"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4043610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="587" mass="65137" checksum="30A68682CC49B69C" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SWD9</accession>
    <name>A0AAN6SWD9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">mRNA export factor MEX67</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">C8A01DRAFT_12033</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the export of mRNA from the nucleus to the cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NXF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854318">
        <property type="protein sequence ID" value="KAK4044556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SWD9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14342">
        <property type="entry name" value="UBA_TAP-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000296">
        <property type="entry name" value="mRNA export factor MEX67"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002075">
        <property type="entry name" value="NTF2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018222">
        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030217">
        <property type="entry name" value="NXF_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005637">
        <property type="entry name" value="TAP_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10662">
        <property type="entry name" value="NUCLEAR RNA EXPORT FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10662:SF22">
        <property type="entry name" value="NUCLEAR RNA EXPORT FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14580">
        <property type="entry name" value="LRR_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22602">
        <property type="entry name" value="NXF_NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03943">
        <property type="entry name" value="TAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00804">
        <property type="entry name" value="TAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50177">
        <property type="entry name" value="NTF2_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51281">
        <property type="entry name" value="TAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NTF2" evidence="12">
        <location>
            <begin position="394"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="TAP-C" evidence="13">
        <location>
            <begin position="593"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00055253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK4044556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="648" mass="70650" checksum="778C10FEC6B2BF9A" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P5I8</accession>
    <name>A0AAN6P5I8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Intradiol ring-cleavage dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_50983</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the intradiol ring-cleavage dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854641">
        <property type="protein sequence ID" value="KAK4032164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P5I8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018576">
        <property type="term" value="F:catechol 1,2-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009712">
        <property type="term" value="P:catechol-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.130.10">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007535">
        <property type="entry name" value="Catechol_dOase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000627">
        <property type="entry name" value="Intradiol_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015889">
        <property type="entry name" value="Intradiol_dOase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050770">
        <property type="entry name" value="Intradiol_RC_Dioxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33711">
        <property type="entry name" value="DIOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33711:SF5">
        <property type="entry name" value="INTRADIOL RING-CLEAVAGE DIOXYGENASE PRCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00775">
        <property type="entry name" value="Dioxygenase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04444">
        <property type="entry name" value="Dioxygenase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49482">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catechol dioxygenase N-terminal" evidence="8">
        <location>
            <begin position="28"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Intradiol ring-cleavage dioxygenases" evidence="7">
        <location>
            <begin position="113"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4032164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="301" mass="33897" checksum="E19E1DE0381917DE" modified="2024-10-02" version="1">MASDKPSHRFDPNFTAQVVEGMGPNTTPRNREVLGALIRHIHDFAREVELTIPEWMEGVKFINALGEIYVKSNKTRNETHRICDVIGLESLVDEIAHKIVSETGMDPTSSSILGPFWSPNAPFREHGDVIFQDGVPPNGRVTKMHGVIRDITTGKPIPNAVFDIWQASANGKYDFQDPDNQTPNNLRGKFRADADGKYSFYCLHPTAYSLPRDGPSWDLLTMMDRHPMRPAHIHIMVTHDDFQGCTTQLYPSDDPWIKNDTVFAVKDDLVVEFKPLQGDDKAVLELEYNVALAPKGYKGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P619</accession>
    <name>A0AAN6P619_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SAGA complex subunit Spt7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">C8A01DRAFT_41292</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854628">
        <property type="protein sequence ID" value="KAK4032275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P619"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046695">
        <property type="term" value="C:SLIK (SAGA-like) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="Bromo_SPT7_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22927">
        <property type="entry name" value="HFD_SPT7"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Transcriptional activator spt7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.10:FF:000032">
        <property type="entry name" value="Transcriptional activator spt7"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006565">
        <property type="entry name" value="BTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037782">
        <property type="entry name" value="Spt7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47343">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR SPT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47343:SF1">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR SPT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07524">
        <property type="entry name" value="Bromo_TP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromo" evidence="10">
        <location>
            <begin position="338"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="84"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="236"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="433"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="976"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1028"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1084"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="101"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="162"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="179"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="195"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="240"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="255"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="433"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="448"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="480"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="531"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="1091"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1118"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="1129"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1150"/>
            <end position="1170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00093633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK4032275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1192" mass="129391" checksum="BD38CCE30E3311F4" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P625</accession>
    <name>A0AAN6P625_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fungal N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_20473</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854609">
        <property type="protein sequence ID" value="KAK4032449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P625"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4032449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1110" mass="123365" checksum="5E8806CA6AF6FD9B" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P682</accession>
    <name>A0AAN6P682_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_51408</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854765">
        <property type="protein sequence ID" value="KAK4031552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P682"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4031552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="171" mass="19001" checksum="8F6447100C38327E" modified="2024-10-02" version="1">MPAVISIKGSLDECAQGGSDLIHLISASLTLSQKVKWLLSSRPEVDLLAGLTDPSTNSLDASKSLVELDTQRLKDPVNAFIDHKLMELKYGEGYDDRVLAEVSHEVRQRAENTSVDGWDAVETVQSIPPGLTDLYGHMMARIDGGNERNRQRYKNGIWTSAYVQLIQCPRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P6A4</accession>
    <name>A0AAN6P6A4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heterokaryon incompatibility protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_21264</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854773">
        <property type="protein sequence ID" value="KAK4031535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P6A4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF16">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="205"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4031535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="722" mass="80166" checksum="06497FA4C4622E83" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P6F9</accession>
    <name>A0AAN6P6F9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_41879</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854731">
        <property type="protein sequence ID" value="KAK4031672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P6F9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4031672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="297" mass="31751" checksum="00FF99C21B0A40F9" modified="2024-10-02" version="1">MSSPMSTTPVESPERAGEEDSSVNLLEVVRAGLEHGLRDTVEVSDEEQRQLLVALTTAIARTAALRGIDFAATAARSGETILPVDNTILELFPARQREDLGSDNLTVAEACDQLVNVTSPRARPWNCALKSRAPKPSHRTWSPAMSRTGPCPTYPYHLFQRMNPPRWTYPAVAVRRHMPPPPTAPLPPTPAATTAAFPTSVPGLIPRATFRPATGPAFDPAPAPAPAQAANNRAMTLGEARVFYSHVALTLDRMDESTDTQTAINIAFYDGAVPCACGLGPEGGDLCEMGYEPGATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P702</accession>
    <name>A0AAN6P702_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_51409</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854765">
        <property type="protein sequence ID" value="KAK4031553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P702"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37542">
        <property type="entry name" value="HELO DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37542:SF1">
        <property type="entry name" value="PRION-INHIBITION AND PROPAGATION HELO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="157"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4031553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="470" mass="52310" checksum="BC72F57604F59094" modified="2024-10-02" version="1">MSIINGVEACYKYGKALVDFCQRWKDADAELADRVIMVELCWMNTSAQLQLVEMLHPVLNDEIRRIFDDSLAVLARKLDLTVVQAQKLQDPCSSARPGFLHFRRRASGAKYAWNQTVLDAAIQDLEAWQGRCKVALDLNMRDPNPLIDERLKKLRQTQHPMDAAVGAQGATATTTAASPLSLTGGIRDALQPMGTQPSVFLPNVVFETTAIPFSRARAACMQSPFKTRWFILDTLPCRPETNVRALQNDVRDLALKLGRADPFAFGLLNCKGAMRAFKPPPRQLDLAGFDLVFNVPEGTDAKRLQSLRALLLSRDGAPSLSRRVRLAQELATSVSYVHTFIFVHKNIRPESVLLFQETQGGGGSSQPGTCSATPANRRTSFLIGFESFRSAARDTSLTGDQDWAHNIYRHPERMGEFPAEAYTMQHDIYSLGVCLLEIGLWEPLVEYVYRSGGDAEPEWLIDAAVRWIAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P797</accession>
    <name>A0AAN6P797_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_51058</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854654">
        <property type="protein sequence ID" value="KAK4032075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P797"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052374">
        <property type="entry name" value="SERAC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182:SF2">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="7">
        <location>
            <begin position="26"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4032075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="293" mass="32777" checksum="943D2A525F0785FC" modified="2024-10-02" version="1">MGLTKSLVLEVLHDPGAQGITATVDVVLIHGLNGDSVKTWTHETTQVCWPRDLLPDVLPSARVLSLCYNADIHGNTSVAGIRGNAQVLLARLRDLRDEGNHDKPIVFVAHSLGGIILKQALYLAQLDRRCHALFSATRGLLLYGTPHFGADQSRWLSMAKSFAPLISRRFSMRSSHTKLVDSLTRHSPDISNICEDFRFLARRFAIVSFYETEVWPGTRAPILERMNSLMHLEHEEQVPLEANHVNLCRFRDAHDSGFMLSCRYIAQISQGIGHGPDERLVLEVWGGNGLVEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P821</accession>
    <name>A0AAN6P821_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_40068</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854528">
        <property type="protein sequence ID" value="KAK4033466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P821"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042975786" evidence="2">
        <location>
            <begin position="24"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4033466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="294" mass="29772" checksum="36A2CC82327D1DA8" modified="2024-10-02" version="1">MKPIILPMTLLLPFALTLPTTTANDNHPRDDTSVTQQQQQQQQATPEPNPTLDPNTNTQDTPKPKPNENENLLRPPMPVMAPPLPGMIPGMIPPAMPGMVVPPAMPGMVPPMMLPPAMPLMMPFRGVTKRAEGDLGDGGFGFGYGSGSGVGGGVGGGVGGGVVGVDAQAQHMAQMQALAQAQAQAQAQAQAAQMLGVPGVPGGLGGGLSGRDEQAGQGGQGGPGVEGAEGVEGVQAKGAYPGVGAGYYGNGAGVGVPGYAAPYVYPYGYAPYAPYAPYAPYAPYAPYAPYPQVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P868</accession>
    <name>A0AAN6P868_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_41001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854597">
        <property type="protein sequence ID" value="KAK4032540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P868"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF5">
        <property type="entry name" value="HEAT SHOCK 70 KDA PROTEIN 12A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4032540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="154" mass="16729" checksum="CB94AEF3E65C7C07" modified="2024-10-02" version="1" fragment="single">MASMGPEVGNTVIIGIDFGTTYSGVAFTCSKKIDSIEVIASWDSELPSNCDEDKTPTAISFGPQNQVTWGYNIPFDAEQAKWFKLLLIDDKDLPDEVRGSDKIREARAYLEKHNITTAGDTFVVADCGGGTADIISYEVVTISPMVVRNASKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P872</accession>
    <name>A0AAN6P872_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_21262</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854772">
        <property type="protein sequence ID" value="KAK4031536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P872"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4031536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="59" mass="6908" checksum="5351DD9615F06DD4" modified="2024-10-02" version="1" fragment="single">DITIDFVTSLLTLFDPRSNKPYNTILVIIDKFTKYTIYIVTTKALTASTFVELFFDYIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P8C3</accession>
    <name>A0AAN6P8C3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">2-amino-3-carboxymuconate-6-semialdehyde decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_50942</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854633">
        <property type="protein sequence ID" value="KAK4032228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P8C3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000055">
        <property type="entry name" value="Uracil-5-carboxylate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="2-AMINO-3-CARBOXYLMUCONATE-6-SEMIALDEHYDE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240:SF28">
        <property type="entry name" value="ISO-OROTATE DECARBOXYLASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="4">
        <location>
            <begin position="103"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4032228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="385" mass="41179" checksum="2DCD64F286847957" modified="2024-10-02" version="1">MTLQIPISPVVDIHTHMYPPEYISILSSRDTIPLVRTFPSSPDPRLILLESEIPSLELALTDPTAPLPGRPLTKSFTSLPAKLAFMSRHNITTSVLSLANPWLDFLPPDEAGATAHEINTSFESMCASEPGRLYFFGTLPLTAPLETILASITHLTTLPHCRGIILGTSGLGSGLDDPSLLPIFSALATSTLPIFLHPHYGLPNAVYGPRSAAGEYGHVLPLALGFPMETTIAVARMFLAGVFDAVPELRMILAHSGGTLPFLAGRIESCVLHDAALVGKMGGKEGKRRRTVWEVLREQVYLDAVIYSEVGLKAAVEAGGGADRLMFGTDHPFFPPVGVEGGGEDGVWESVGLNVQAVDKALGEGSEEARMVMGGNAVRVLRLFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P8T6</accession>
    <name>A0AAN6P8T6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NYN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_40628</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854564">
        <property type="protein sequence ID" value="KAK4032917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P8T6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:RNA nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021139">
        <property type="entry name" value="NYN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01936">
        <property type="entry name" value="NYN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NYN" evidence="2">
        <location>
            <begin position="24"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4032917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="461" mass="53799" checksum="BC40F0A31CE601EC" modified="2024-10-02" version="1">MSTKKHPNGRHYGNIFIYIDNSNLWIQGQRTYAEKRGLDVSWDPTWRFDVGRLRDILLSNSGLRADEKTFDVKVDLYGSTPPPVDTVWKAIESHNVKVNTFERSSWTRREKQVDAELIADSIEQASEAYHKQMPTVFIIVSGDRDVRSAVVRITRKYHCQVHLWSWKNGLATVYKRNDEEIAQGLFEVHFLDDYLEKVGFHANIFRVDRAVINPHSIVVLDPLPKADKVEEFLKRLRTPVYRYEVVPKRADASSQDLAIIPAFAWSMESDKLRGLFMESKAKLEAKGLSVLSYLEYTQKYADRAGADKSLAISNRFDELPEDEGGEDEDGRDESEEDDNKNQESEVEDEWIEVNRGLDRKRGRLRKNEDNSRLRCRWRMYCSRALDCKYGHTKEEEEYFRVYGSRKAKKFQYCWREDCIKGRGCIFAHEVEELFCPTCGETGAHEMHDCPERYHVPSARRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P917</accession>
    <name>A0AAN6P917_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_41557</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854662">
        <property type="protein sequence ID" value="KAK4032016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P917"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4032016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="158" mass="16621" checksum="42F26A286203C33D" modified="2024-10-02" version="1">MGYALVFRAMSVAEFRRRVAADPVVAAFRDAGNGEPTQEVADTVVRIALAMGTEVGTTGHSVAGGEWFREELFDGVLAGLVGADLADHLLSRSLEGIVWSDYPMVGWVLNGELGEGLAGVREDLPSDLDEDDADVVANVLAALRAAAEASQDLVTVYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P9A0</accession>
    <name>A0AAN6P9A0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Shr3 amino acid permease chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_40412</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854550">
        <property type="protein sequence ID" value="KAK4033125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P9A0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013248">
        <property type="entry name" value="Psh3/Shr3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28228">
        <property type="entry name" value="SECRETORY COMPONENT PROTEIN SHR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28228:SF1">
        <property type="entry name" value="SECRETORY COMPONENT PROTEIN SHR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08229">
        <property type="entry name" value="SHR3_chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029187">
        <property type="entry name" value="Shr3_AAP_chap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00786">
        <property type="entry name" value="SHR3_chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4033125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="230" mass="24827" checksum="7941F77ABC4B1E8D" modified="2024-10-02" version="1">MPTQWVDWSKTTHSKDYRGSGSFATFLIIGPVCFALGILFASFPYDFPLLWTSDPIPPSYLDHLETHLRFMHQSPPLIARMLHIIIFVGFLGFFIKLFRPSEANVLFDGGSLILYVIGAGVYLSNIVKGMRAVSQPGGLAAAVEAEAVAAGAGQTVHTGPFTGEVVLGREESLRVLSASHVILALVLVGVLVLQAGQWYAERKEADDVAKLEREAAERKGAAGAGGKKKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P9B3</accession>
    <name>A0AAN6P9B3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_49447</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854496">
        <property type="protein sequence ID" value="KAK4034075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P9B3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022198">
        <property type="entry name" value="DUF3723"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12520">
        <property type="entry name" value="DUF3723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4034075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="349" mass="39447" checksum="5AD2DF363C9D0D3A" modified="2024-10-02" version="1">MSLGAVRVPLDSLEFPDRRQISFKVRERLGRVFRNLSKAGATEVRIPCTVEEGKFGQILARLGLSADQLRGTRGRGQRDLPLLTGVTLSCLYGDYLVAAAKGNKETSLIVHLFTTDLLDPLLEVISTFSHEPQQSDGELYQKIVESYRRDEVKYALCMGALTGPKERNMKMLLRPKNLLIVEALNSLFDIPAMMEQLLLGNIHKWLALHIDEQIINYLNHISMVWKEKICQGKKTIMQSLDIDSIRIVQFRMPTVCSGDADTIKRLFDNGTLFPGVADPSDRDMLQRNVLSLDMVIPSFETFQENMHYIGLAAKILIRHVVDKLPLCKSSRKRSPTIFEVLSGRWPPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P9H1</accession>
    <name>A0AAN6P9H1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_49401</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854492">
        <property type="protein sequence ID" value="KAK4034165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P9H1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098852">
        <property type="term" value="C:lytic vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04159">
        <property type="entry name" value="Arl10_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001015">
        <property type="entry name" value="ADP-ribosylation factor-like protein 8B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044154">
        <property type="entry name" value="Arl8a/8b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45732">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45732:SF7">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="27"/>
            <end position="34"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="130"/>
            <end position="133"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4034165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="183" mass="20744" checksum="2144655BE2B966F4" modified="2024-10-02" version="1">MAGLFRKVYDWLLRTFWATEMDVTMIGLQNAGKTSLLRVLSGGEFAIDSIPTVGFNMKRVQRGHVTLKCWDLGGQPRFRPMWERYCRNVNAIVFIVDIADLNLLPVAREELHALMTQPTLEGIPLLVLGNKSDLPNKLSVDELIDALDLKNVAHREVSCYGISAKEETNLEAVLQWLMKFANR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PAB2</accession>
    <name>A0AAN6PAB2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Amidoligase enzyme-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_19408</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854516">
        <property type="protein sequence ID" value="KAK4033682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PAB2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022025">
        <property type="entry name" value="Amidoligase_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36847">
        <property type="entry name" value="AMIDOLIGASE ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36847:SF1">
        <property type="entry name" value="AMIDOLIGASE ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12224">
        <property type="entry name" value="Amidoligase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4033682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="361" mass="41199" checksum="B480BC18AA48332D" modified="2024-10-02" version="1">MSTSRISDCPGLRFGVEIELVVRSKRRKHTTFESLASEICQHLDKAKISSHIGSLSQKSNATETYHDWTIIRDSTLPSTPEENIFGVELVSPIFYFQKKHIWAVQVQKLWRVLESQFEVHATKECSTHVHLSPGNGPWSLNEAKGIAKATIFFERCIDALMPGHRRINPYCMSNRRNPEYNQLHVPLIFSNISQAESPETLGDHMCLCSKDSIHAQQTLHDEDFVHPHFRWNFTSLTERTRTIEFRQPPASKDAKDTITWILFAVSFAQWASERANTALDPTQTDGIADLYKYVMAGAQLSGVSNATMPGLLEKLFQGAKRLPVPRYDLKSMTEDEHDKMEMEGKKKGIPLDKYKELFAYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PAB5</accession>
    <name>A0AAN6PAB5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_38889</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854471">
        <property type="protein sequence ID" value="KAK4034630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PAB5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="216"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="263"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="428"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="271"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="319"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4034630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="530" mass="59309" checksum="7D73D8437638D27C" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PAC1</accession>
    <name>A0AAN6PAC1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcription factor gsfR2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_39811</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854513">
        <property type="protein sequence ID" value="KAK4033725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PAC1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4033725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="398" mass="43050" checksum="2F06BF5AACA9A451" modified="2024-10-02" version="1">MPPANSRRRASPPLPYFVDVLPAADPVGLAGHGASAFQDFLDGLHARAGSNSTTGNSSVGIPVVSDYADNPWPIFFDASGPANTSITRASMAYCVKEYRAWPRRWVAEASTPFIHPALYAGSAATRTVPRSEVATALGLGSNSLTGLPPVLQDAFAVSAAYAAKNAANSDLVMQLVESKATALLYSPDQGNWTIMEQLAALQALLVYQMVRLFDGDIRQRALAETVEPVQAAWTAALQARVGGEIFQGVDLQQAAMLDPLASAQFASGAGNHSAHAVTVNDDPATAWQRWLFNETARRTIITSFMIQGIYAMAKQGYCRLGPVVTDMSFTSGSRLWAAKTPGRWRRAVGETDPGWVNRMDFVDMLGRADPRNLDEFGVMMAVTYRGKDVIEDWMDREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PAC5</accession>
    <name>A0AAN6PAC5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Copalyl diphosphate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_18597</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the terpene synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854471">
        <property type="protein sequence ID" value="KAK4034645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PAC5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010333">
        <property type="term" value="F:terpene synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016102">
        <property type="term" value="P:diterpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017057">
        <property type="entry name" value="Ent-kaurene_synthase_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050148">
        <property type="entry name" value="Terpene_synthase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31739:SF25">
        <property type="entry name" value="(E,E)-GERANYLLINALOOL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31739">
        <property type="entry name" value="ENT-COPALYL DIPHOSPHATE SYNTHASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036498">
        <property type="entry name" value="Ent-kaurene_synthase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="702"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="785"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="786"/>
            <end position="815"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4034645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1000" mass="110826" checksum="782C20814E869020" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PAP2</accession>
    <name>A0AAN6PAP2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GTP-binding protein ypt1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_39646</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Preautophagosomal structure membrane</location>
            <topology evidence="8">Lipid-anchor</topology>
            <orientation evidence="8">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854505">
        <property type="protein sequence ID" value="KAK4033877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PAP2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01869">
        <property type="entry name" value="Rab1_Ypt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000069">
        <property type="entry name" value="Ras GTP-binding protein YPT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057289">
        <property type="entry name" value="Rab1/Ypt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0636">Prenylation</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00060489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00074496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4033877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="203" mass="22489" checksum="3BEF05DE391388C6" modified="2024-10-02" version="1">MNPEYDYLFKLLLIGDSGVGKSCLLLRFADDTYTESYISTIGVDFKIRTIELDGKTVKLQIWDTAGQERFRTITSSYYRGAHGICVVYDVTDMDSFNNVKQWLQEIDRYATEGVNKLLVGNKSDMADKKVVEYTVAKEFADSLGIPFLETSAKNASNVEQAFLTMARQIKERMGSSIATNNTKANVNVAPGQGVSNNQSGGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PAR9</accession>
    <name>A0AAN6PAR9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_38643</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854462">
        <property type="protein sequence ID" value="KAK4034878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PAR9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4034878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="192" mass="20574" checksum="0C5F250874EACE38" modified="2024-10-02" version="1">MAIARLTHPSRAHRSSLRCGSTFLAWVATFVLLLAFSSLFGVPPTATAAPAPLSLRDTRSTEDHVSLAHHSQALDHPSLPLEADAAITTHGASSNSRTDPKQDAIDGTYADTTLPAAVNMKVVDRLVDRLVDVVGTCLFWLVGFMVRIYVGWLWRGVVGVWGEVHARQNSHHQDGVGREVVGGGGLIYAGMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PAY7</accession>
    <name>A0AAN6PAY7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_38481</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854457">
        <property type="protein sequence ID" value="KAK4035026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PAY7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="459"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4035026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="517" mass="59127" checksum="9E5A1AD01E3B1B7D" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PBE9</accession>
    <name>A0AAN6PBE9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Fungal-specific transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_49235</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854483">
        <property type="protein sequence ID" value="KAK4034340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PBE9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF49">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="17"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="54"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4034340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="705" mass="79001" checksum="DB0A06ABAD4E26AB" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PCG5</accession>
    <name>A0AAN6PCG5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Six-hairpin glycosidase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_19586</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854528">
        <property type="protein sequence ID" value="KAK4033467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PCG5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11748">
        <property type="entry name" value="GH94N_NdvB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000046">
        <property type="entry name" value="Cellobionic acid phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.40">
        <property type="entry name" value="Glycoside hydrolase, family 65, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.420.10">
        <property type="entry name" value="Maltose phosphorylase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037018">
        <property type="entry name" value="GH65_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033432">
        <property type="entry name" value="GH94_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052047">
        <property type="entry name" value="GH94_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037814">
        <property type="entry name" value="GH94N_CBAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010383">
        <property type="entry name" value="Glyco_hydrolase_94_b-supersand"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37469:SF2">
        <property type="entry name" value="CELLOBIONIC ACID PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37469">
        <property type="entry name" value="CELLOBIONIC ACID PHOSPHORYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06165">
        <property type="entry name" value="GH94_b-supersand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17167">
        <property type="entry name" value="Glyco_hydro_94"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl hydrolase 94 supersandwich" evidence="3">
        <location>
            <begin position="76"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase 94 catalytic" evidence="4">
        <location>
            <begin position="319"/>
            <end position="716"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4033467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="791" mass="89661" checksum="E5E71E114B8EE054" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PCJ4</accession>
    <name>A0AAN6PCJ4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_39276</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854487">
        <property type="protein sequence ID" value="KAK4034268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PCJ4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043052326" evidence="1">
        <location>
            <begin position="20"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4034268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="50" mass="5287" checksum="9BC15CE636408C31" modified="2024-10-02" version="1">MKFTTIITAVALLATSALAVPSPKAEPEANPQICYCNLGCYDSCGQKFCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PD33</accession>
    <name>A0AAN6PD33_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">von Willebrand factor type A domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_49087</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854475">
        <property type="protein sequence ID" value="KAK4034553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PD33"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013694">
        <property type="entry name" value="VIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45737">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45737:SF6">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08487">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="VWA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00609">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VIT" evidence="3">
        <location>
            <begin position="11"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="289"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="685"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="754"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="768"/>
            <end position="779"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4034553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="918" mass="99604" checksum="7644B218D7F45AAC" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PD59</accession>
    <name>A0AAN6PD59_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_37360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854421">
        <property type="protein sequence ID" value="KAK4038718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PD59"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024242">
        <property type="entry name" value="NCE101"/>
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    <dbReference type="Pfam" id="PF11654">
        <property type="entry name" value="NCE101"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4038718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="49" mass="5381" checksum="ABA156B4CE99EC13" modified="2024-10-02" version="1">MAPPVYIISRVADPIFAVVIGVSAAALRINREEKEKGKTTRDTIEAARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PDJ5</accession>
    <name>A0AAN6PDJ5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7598 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_17017</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854415">
        <property type="protein sequence ID" value="KAK4038928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PDJ5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056019">
        <property type="entry name" value="DUF7598"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24535">
        <property type="entry name" value="DUF7598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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            <end position="112"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7598" evidence="3">
        <location>
            <begin position="14"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4038928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="311" mass="34586" checksum="B38F15C3FC1494C6" modified="2024-10-02" version="1">MFSLGQDSKLLGAGHVVLNVLRAFNMIGLAAVMMASMVMPVLSGIKGHFFFFDMITHVFVFLLATFLFVSELPVPWKKLKGYYERNWPVLSQDHSLAWLGWGMVFIGFQILGDAWKPAYTVETIGLDWWRALLAAAILSVTFGFFNICASVLFRTSMEGLRGEKVTVTSRQIRTHGNLALQNAASKGDDIEASLASHYSPPHRDNWSARSWSKEAAEEEVVEPSSAVQRITRVFNPRNFRKSRIQISKPIPQDMAVVDDGRGQTSYSQGSHGGYDADRGSPVVPGLQRPPSALHPAYTGASRYSEAHMDRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PEL3</accession>
    <name>A0AAN6PEL3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_36536</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854399">
        <property type="protein sequence ID" value="KAK4039498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PEL3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043033560" evidence="3">
        <location>
            <begin position="17"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4039498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="126" mass="12934" checksum="258EC81A636FB2A2" modified="2024-10-02" version="1">MKYTAVLFSLLAVATAANLHNANPATADIVARELDQGGSRGPGGRDDHEHEHEHVDGSGQEQHKRDLEKRRGGGAGSFHAGSSSHRTGTSTNSSSSHKSDASAFMNLNVGVLVAGVAGAGVGAVFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PEV9</accession>
    <name>A0AAN6PEV9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Elongation factor Tu</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">C8A01DRAFT_47665</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
            <dbReference type="EC" id="5.3.4.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854419">
        <property type="protein sequence ID" value="KAK4038788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PEV9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070125">
        <property type="term" value="P:mitochondrial translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01884">
        <property type="entry name" value="EF_Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03697">
        <property type="entry name" value="EFTU_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03707">
        <property type="entry name" value="EFTU_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00238">
        <property type="entry name" value="ERp29c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02998">
        <property type="entry name" value="PDI_a_ERp38"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000001">
        <property type="entry name" value="Elongation factor Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000003">
        <property type="entry name" value="Elongation factor Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000032">
        <property type="entry name" value="Protein disulfide-isomerase A6 homolog"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1150.12">
        <property type="entry name" value="Endoplasmic reticulum resident protein 29, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00118_B">
        <property type="entry name" value="EF_Tu_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041709">
        <property type="entry name" value="EF-Tu_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050055">
        <property type="entry name" value="EF-Tu_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033720">
        <property type="entry name" value="EFTU_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011679">
        <property type="entry name" value="ERp29_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036356">
        <property type="entry name" value="ERp29_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005788">
        <property type="entry name" value="PDI_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004541">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_bac/org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004160">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00485">
        <property type="entry name" value="EF-Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01126">
        <property type="entry name" value="pdi_dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000766">
        <property type="entry name" value="PRK00049.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009372">
        <property type="entry name" value="PRK12735.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009373">
        <property type="entry name" value="PRK12736.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721:SF36">
        <property type="entry name" value="ELONGATION FACTOR TU, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721">
        <property type="entry name" value="ELONGATION FACTOR TU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07749">
        <property type="entry name" value="ERp29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03143">
        <property type="entry name" value="GTP_EFTU_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47933">
        <property type="entry name" value="ERP29 C domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 20" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tr-type G" evidence="19">
        <location>
            <begin position="51"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="18">
        <location>
            <begin position="447"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="18">
        <location>
            <begin position="574"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU004061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU004208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAK4038788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="809" mass="87706" checksum="0B2599E91AD4EB24" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PEW7</accession>
    <name>A0AAN6PEW7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA/RNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_16365</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854394">
        <property type="protein sequence ID" value="KAK4039714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PEW7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005697">
        <property type="term" value="C:telomerase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070034">
        <property type="term" value="F:telomerase RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018834">
        <property type="entry name" value="DNA/RNA-bd_Est1-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045153">
        <property type="entry name" value="Est1/Ebs1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696">
        <property type="entry name" value="SMG-7 SUPPRESSOR WITH MORPHOLOGICAL EFFECT ON GENITALIA PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696:SF0">
        <property type="entry name" value="TELOMERASE-BINDING PROTEIN EST1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10373">
        <property type="entry name" value="EST1_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA/RNA-binding" evidence="2">
        <location>
            <begin position="229"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4039714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="307" mass="34691" checksum="BD7F7E6BDD132E9F" modified="2024-10-02" version="1" fragment="single">MTCSPGSRKCRLRGGSSSRSPPKGLTASGVSLADSPDNTQHKRPRAPDDTHSEVLKHSGTHRLKSTPDKCNSSPANRRCELLKQPEMRPISQEQLAAEVKGIYAGLVVMESKCIEVDEAQNTKSDPANKLNNDQWQTLIALHRILLHEHHDFFLASQHPSASPALRRLAAKYAMPARMWRHGIHSFPLYDTVPAFEDTWIECLGDLGRYRMAIEDGDIRDREVWTAVSRHWYSRASDKAPTTGRLYHHLAILARPNALQQLYYYSKSLCVEMPFLSARESIMTLFEPLISRTSNPQQARLPPTELNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PFB9</accession>
    <name>A0AAN6PFB9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mediator of RNA polymerase II transcription subunit 10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Mediator complex subunit 10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MED10</name>
        <name evidence="10" type="ORF">C8A01DRAFT_46667</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Mediator complex subunit 10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854388">
        <property type="protein sequence ID" value="KAK4039939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PFB9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019145">
        <property type="entry name" value="Mediator_Med10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13345">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13345:SF13">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09748">
        <property type="entry name" value="Med10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0010">Activator</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4039939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="152" mass="16973" checksum="82371FCE6F6E8CDC" modified="2024-10-02" version="1">MAPINPDLQNVQEDIKNVIQDLFQVLVQVSNYDSAGRPTRDVLAQDIQTLDNTLHTLHTNSLHLPTPSANKPIPEPLIQYVENGRNPDIYTREFVELVRRMNQLARGKMHAFRGFRDVLAAEMQSALPELRGDVEAVVGATGGVTLRAESMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PFZ8</accession>
    <name>A0AAN6PFZ8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_37781</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854434">
        <property type="protein sequence ID" value="KAK4038264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PFZ8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="243"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4038264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="746" mass="82523" checksum="6271A0B61A7CF02D" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PG27</accession>
    <name>A0AAN6PG27_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-coenzyme A thioesterase THEM4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_15829</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854380">
        <property type="protein sequence ID" value="KAK4040271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PG27"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052061">
        <property type="entry name" value="PTE-AB_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260:SF6">
        <property type="entry name" value="THIOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260">
        <property type="entry name" value="UPF0644 PROTEIN PB2B4.06"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="1">
        <location>
            <begin position="105"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4040271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="204" mass="22152" checksum="88AE9538BB27FA2C" modified="2024-10-02" version="1">MTAGTTLAQANAAAAAQQIAHFRAIPWCAAHLASSPSMIIDQSVSRRLTPTARDTLLSRALNTPDAIPAYITFYNPPNSEKEERGLIREVKSFLALGPLLNGWEGICHGGIVVTMLDEVMGQVFAANKMQGLMVDVPVMTGYLNTRFERPVRTGTVEEPAVVLVTGRLVRQEGRKYWMEGDVQGEGGVVLARGEALFVMLRGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PG30</accession>
    <name>A0AAN6PG30_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_46256</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854378">
        <property type="protein sequence ID" value="KAK4040359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PG30"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051911">
        <property type="entry name" value="SDR_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976:SF9">
        <property type="entry name" value="OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043035355" description="NAD(P)-binding domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4040359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="258" mass="27599" checksum="07F383D9AC959A21" modified="2024-10-02" version="1">MPPLIWLITGATFGLGEALVSHIVARGDRAVPTSRQAEQRLAALRSDNVVVVDLDVSASRECRGGGEEGEGCLFGRSISCHVPLFPLTRRGAVAFIGAGVAWAPIAFLAHYPAAKAALDRFVEGLRKELHGQGIHCTVFKPGGFASQLTRPRSESDEGFGQYQPAVQDYAGLFAETMDVFSSEIALSVPGDVVKRRGGMAGQLPVRVVLGSDAVALVDQKCREQLGLLGEFEHVSLTDRGDADGFRYEGMLRLTSMLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PG93</accession>
    <name>A0AAN6PG93_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">H/ACA ribonucleoprotein complex subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Nucleolar protein family A member 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">C8A01DRAFT_16590</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Common component of the spliceosome and rRNA processing machinery. In association with the spliceosomal U4/U6.U5 tri-snRNP particle, required for splicing of pre-mRNA. In association with box C/D snoRNPs, required for processing of pre-ribosomal RNA (rRNA) and site-specific 2'-O-methylation of substrate RNAs. Essential for the accumulation and stability of U4 snRNA, U6 snRNA, and box C/D snoRNAs.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
            <location evidence="1 10">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854400">
        <property type="protein sequence ID" value="KAK4039450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PG93"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000002">
        <property type="entry name" value="NHP2-like protein 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002415">
        <property type="entry name" value="H/ACA_rnp_Nhp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004037">
        <property type="entry name" value="Ribosomal_eL8-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018492">
        <property type="entry name" value="Ribosomal_eL8/Nhp2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00881">
        <property type="entry name" value="L7ARS6FAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00883">
        <property type="entry name" value="NUCLEARHMG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01082">
        <property type="entry name" value="RIBOSOMAL_L7AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10 12" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="11">
        <location>
            <begin position="24"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK4039450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="129" mass="13939" checksum="5AAC160A63B46481" modified="2024-10-02" version="1">MSAAQNESAAWPKAEDPALVQELLDCVQQASHYRQLKKGANEATKSINRGTSELVILAADTQPLSIVLHIPLISEEKNVPYVYVPSKVALGRACGVSRAVIAVSLTSNEASDLNSKIRALRDKVERLAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PGK8</accession>
    <name>A0AAN6PGK8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_15532</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854373">
        <property type="protein sequence ID" value="KAK4040614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PGK8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005871">
        <property type="term" value="C:kinesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000091">
        <property type="entry name" value="Kinesin family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000120">
        <property type="entry name" value="Kinesin family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24115:SF1008">
        <property type="entry name" value="KINESIN-LIKE PROTEIN SUBITO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24115">
        <property type="entry name" value="KINESIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0493">Microtubule</keyword>
    <keyword evidence="4 5" id="KW-0505">Motor protein</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="8">
        <location>
            <begin position="11"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="187"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="314"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="603"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="823"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="860"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="663"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="221"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="314"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="338"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="603"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="108"/>
            <end position="115"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4040614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="898" mass="97359" checksum="1608AF05E77F862D" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PHE0</accession>
    <name>A0AAN6PHE0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_47265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854406">
        <property type="protein sequence ID" value="KAK4039241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PHE0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00048">
        <property type="entry name" value="DSRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="114"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4039241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="124" mass="13856" checksum="3EEDAE0A0A986ED6" modified="2024-10-02" version="1">MGGFYMQYLESLCRRRGWHDPTYECYRDSNGYTCLVLVNGRKYQTDLAYESGTLAQENAAMRAFMVCRNFSVNGGMLARNGIVQGLPAEEAGRKARSSRHPSSNHGHRSRSSHHSSSSSTTSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PHU2</accession>
    <name>A0AAN6PHU2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein transport protein SEC24</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Protein transport protein sec24</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">C8A01DRAFT_45739</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPII-coated vesicle membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SEC23/SEC24 family. SEC24 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854365">
        <property type="protein sequence ID" value="KAK4041012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PHU2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01479">
        <property type="entry name" value="Sec24-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050550">
        <property type="entry name" value="SEC23_SEC24_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041742">
        <property type="entry name" value="Sec24-like_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803">
        <property type="entry name" value="SEC24-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803:SF39">
        <property type="entry name" value="SECRETORY 24AB, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Zinc finger Sec23/Sec24-type" evidence="18">
        <location>
            <begin position="270"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 trunk" evidence="19">
        <location>
            <begin position="344"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 beta-sandwich" evidence="21">
        <location>
            <begin position="591"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 helical" evidence="20">
        <location>
            <begin position="685"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="17">
        <location>
            <begin position="813"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="156"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="158"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00025471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF04815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF08033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAK4041012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="949" mass="103364" checksum="03662DDF4686BCD2" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PHY2</accession>
    <name>A0AAN6PHY2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NUDIX hydrolase domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_45801</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854366">
        <property type="protein sequence ID" value="KAK4040977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PHY2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035539">
        <property type="term" value="F:8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006203">
        <property type="term" value="P:dGTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04678">
        <property type="entry name" value="NUDIX_MTH2_Nudt15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000060">
        <property type="entry name" value="Nudix hydrolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16099">
        <property type="entry name" value="8-OXO-DGTP DIPHOSPHATES NUDT15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16099:SF5">
        <property type="entry name" value="NUCLEOTIDE TRIPHOSPHATE DIPHOSPHATASE NUDT15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="7"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4040977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="155" mass="16998" checksum="DDA7B6AB4FA4FFA9" modified="2024-10-02" version="1">MATQTPVVRVGVAAVIQDAQGRMVLGIRKGSHGDGQWQFPGGHLEMGESPLACAERETLEETGLVVRAEKLVTVTNDVFGPSKHYITLFVLCRRADEAQEPQVLEPHKCACWEWKSWADVRAAIAGEQGQAKVFLPIVNLLRDHPEIEALVEASC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PIF0</accession>
    <name>A0AAN6PIF0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_46049</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854372">
        <property type="protein sequence ID" value="KAK4040678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PIF0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015233">
        <property type="term" value="F:pantothenate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098717">
        <property type="term" value="P:pantothenate import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000065">
        <property type="entry name" value="Putative MFS pantothenate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF4">
        <property type="entry name" value="PANTOTHENATE TRANSPORTER FEN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="278"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="349"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="412"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="446"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="33"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="472"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="482"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4040678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="494" mass="54596" checksum="66A9A12E24F3011E" modified="2024-10-02" version="1">MTATWSKLRDYFSSAWRTDPAERKLVRKIDFFILTFCCLSYFLNYLDRSNLANAYVSGMKEDLGFQGDQLNQINTCFTVGYVLGQIPSNLSLHYVKPRHFFPAMMVVWAGLTMVTASTHTPQAIMAIRFFQGIAEATTFVGTHYILGSWYTERELGKRSGIFTASGLAGTMIGGFIQSGIYTSMDNRHGLRGWRWLFLLDGIITLPVALYGFLLFPDTPATTTAPYLSRAERELAVSRLKLHDPLLGSDHAGNNQEKAPATSPLTWTFAKRVLTSYEWWGFVILWIIAGETESFSSNSLLALYMKSSPSTTYTVKQLNDYPTGVPAVGIVSTLFWAALTDFLGGRRYLVGYFIGVTGVATSGMILAAKAKGTDSTAVVFAAYYWAGTVYACQATFFAWANDAMRYREPVFRSVVLAGMNLGSNAVNAWWSIVFYGASMAPWFERGMYAMIATSVALAVWTAGLSYVSSKAEKRGRVGGTRSPVREEARKAGESG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PIH4</accession>
    <name>A0AAN6PIH4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Sorting nexin-4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Autophagy-related protein 24</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">C8A01DRAFT_45327</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the sorting nexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854355">
        <property type="protein sequence ID" value="KAK4041583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PIH4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07628">
        <property type="entry name" value="BAR_Atg24p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06863">
        <property type="entry name" value="PX_Atg24p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000035">
        <property type="entry name" value="Sorting nexin-4 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000042">
        <property type="entry name" value="Vacuolar targeting protein Atg24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033122">
        <property type="entry name" value="LETM1-like_RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044202">
        <property type="entry name" value="LETM1/MDM38-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015404">
        <property type="entry name" value="Vps5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14009">
        <property type="entry name" value="LEUCINE ZIPPER-EF-HAND CONTAINING TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14009:SF1">
        <property type="entry name" value="MITOCHONDRIAL PROTON_CALCIUM EXCHANGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07766">
        <property type="entry name" value="LETM1_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09325">
        <property type="entry name" value="Vps5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51758">
        <property type="entry name" value="LETM1_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0072">Autophagy</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0967">Endosome</keyword>
    <keyword evidence="14" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="16 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="15 19" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Letm1 RBD" evidence="23">
        <location>
            <begin position="242"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="22">
        <location>
            <begin position="645"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="53"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="474"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="538"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="596"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="776"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="541"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="596"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="624"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="786"/>
            <end position="795"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00040748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00041273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KAK4041583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1073" mass="118395" checksum="C0B20082F559C495" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PJX8</accession>
    <name>A0AAN6PJX8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zonadhesin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_14810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854357">
        <property type="protein sequence ID" value="KAK4041443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PJX8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021840">
        <property type="entry name" value="DUF3433"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544:SF3">
        <property type="entry name" value="SPRAY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544">
        <property type="entry name" value="SPRAY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11915">
        <property type="entry name" value="DUF3433"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
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        </location>
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            <end position="705"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
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        <source>
            <dbReference type="EMBL" id="KAK4041443.1"/>
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            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1237" mass="130337" checksum="7FA5F0FCDE8B5957" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAN6PJZ1_9PEZI</name>
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            <fullName evidence="1">FAD/NAD(P)-binding domain-containing protein</fullName>
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        <name evidence="2" type="ORF">C8A01DRAFT_15690</name>
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        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SULFIDE:QUINONE OXIDOREDUCTASE, MITOCHONDRIAL"/>
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            <end position="170"/>
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    </feature>
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        </source>
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            <dbReference type="EMBL" id="KAK4040439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PK68</accession>
    <name>A0AAN6PK68_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH La-type RNA-binding domain-containing protein</fullName>
        </recommendedName>
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    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_15632</name>
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    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
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    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
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                <person name="Brannstrom I.O."/>
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                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
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                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854375">
        <property type="protein sequence ID" value="KAK4040544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:RNA cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:mRNA stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="LAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DM15"/>
    </dbReference>
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        <property type="entry name" value="La_dom_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006630">
        <property type="entry name" value="La_HTH"/>
    </dbReference>
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        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792:SF132">
        <property type="entry name" value="LA-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792">
        <property type="entry name" value="LUPUS LA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05383">
        <property type="entry name" value="La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21071">
        <property type="entry name" value="LARP1_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00684">
        <property type="entry name" value="DM15"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00715">
        <property type="entry name" value="LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50961">
        <property type="entry name" value="HTH_LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="HTH La-type RNA-binding" evidence="4">
        <location>
            <begin position="612"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="851"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="43"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="82"/>
            <end position="95"/>
        </location>
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        <location>
            <begin position="127"/>
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        </location>
    </feature>
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        <location>
            <begin position="287"/>
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        </location>
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        <location>
            <begin position="355"/>
            <end position="386"/>
        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="492"/>
            <end position="508"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="519"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="852"/>
            <end position="868"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4040544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1021" mass="109163" checksum="0419D67E6D21CB7A" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PK85</accession>
    <name>A0AAN6PK85_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glucan 1, 4-alpha-glucosidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_14065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854343">
        <property type="protein sequence ID" value="KAK4042317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PK85"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="148"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="348"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="414"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="427"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="440"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="468"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="504"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="535"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4042317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="607" mass="64276" checksum="48CF6EBA5A3D121B" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PKD8</accession>
    <name>A0AAN6PKD8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rab proteins geranylgeranyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_33447</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Rab GDI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854340">
        <property type="protein sequence ID" value="KAK4042506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PKD8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005968">
        <property type="term" value="C:Rab-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005092">
        <property type="term" value="F:GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018203">
        <property type="entry name" value="GDP_dissociation_inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017230">
        <property type="entry name" value="Mrs6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787:SF4">
        <property type="entry name" value="CHM, RAB ESCORT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787">
        <property type="entry name" value="RAB GDP-DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00996">
        <property type="entry name" value="GDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037514">
        <property type="entry name" value="Rab_ger_ger_transf_A_fun"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00891">
        <property type="entry name" value="RABGDIREP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR037514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4042506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="492" mass="52615" checksum="C5B05F696A0229F6" modified="2024-10-02" version="1">MESLGDTLWDVVISGTGLQQSLLALALSRSGKKILHIDPNEFYGGPEAAFSLQDAESWVARVSDGTGGLFKSASIAQSESAAGLSSSRAYSLALAPQLIHARSTLLSQLVASRAYRQVEFLAVGSFYIFKPSQDPAQQPSLSRIPSTREEVFSTTAVSTKAKRLLMKFLKFVLDYESSPQQETWQPYADAPLTDLLQTGFKMDAELQTYIVTLTLSLDGKISTKDGLAVIRRHLSSMGVYGPGFAAIYPKWGGLSEIAQVSCRAGAVGGAVYMLGTGIKETETAENEVKLQLTSGDTVKTRMLVRADDNPSDQTGISRLVAVVASPLNALFEAILEGAPRPAVAVIAFPAGSLSTAAAKASEYPVYLSAHSSDTGECPVGQSVLYLTTLATADAKEVLERALDAFVRTTSDGQAAQVLYQLQYEQLAGSDTSGVEGSIFTFPAPSSSLSFDDHTLEPVREAWKKIMGEAAAEAEYMAFEDREGAMDDDDAYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PKD9</accession>
    <name>A0AAN6PKD9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_45324</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854355">
        <property type="protein sequence ID" value="KAK4041580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PKD9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12324">
        <property type="entry name" value="RRM_RBM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008111">
        <property type="entry name" value="RNA-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033744">
        <property type="entry name" value="RRM_RBM8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45894">
        <property type="entry name" value="RNA-BINDING PROTEIN 8A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01738">
        <property type="entry name" value="RNABINDINGM8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="50"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="129"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="140"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4041580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="176" mass="18485" checksum="9BC1A915BAA5619C" modified="2024-10-02" version="1">MASDEMELDEPVQQGPGGIDANNGNGTSSAKLAAMQTLTKATAVRSIEGWIVMVTNVHEEADEEAIHDKFGEFGEIRNVHLNLDRRTGYVKGYALIEYTTLEEARAAIDGANGTELLDQTVQVDFAFVRPPPGKANNTGGRLGGGTGGGGARGSNRGARSGRSRSRSPGAAKDDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PKI1</accession>
    <name>A0AAN6PKI1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Velvet factor-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_44622</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854342">
        <property type="protein sequence ID" value="KAK4042372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PKI1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3960">
        <property type="entry name" value="Velvet domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021740">
        <property type="entry name" value="Velvet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037525">
        <property type="entry name" value="Velvet_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038491">
        <property type="entry name" value="Velvet_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572">
        <property type="entry name" value="SPORE DEVELOPMENT REGULATOR VOSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572:SF18">
        <property type="entry name" value="SPORE DEVELOPMENT REGULATOR VOSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11754">
        <property type="entry name" value="Velvet"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51821">
        <property type="entry name" value="VELVET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0749">Sporulation</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Velvet" evidence="7">
        <location>
            <begin position="1"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="235"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="353"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="395"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4042372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="472" mass="50358" checksum="06CF7FFFB1E70C3E" modified="2024-10-02" version="1">MSTLGQGDFELAVRQQPKYACVAIERKPIDPPPIVQLLVNPRKDPARTFLQNPYLILTARLIRKGDEAQDEQTGPKESDLTGTLVSSLYSLKDTDNSQGGFFVFGDLSVRRVGTYRLAFILYELRLAEKECWLLSRTVSDPFVVYATKTFPGLAESTFLTRSFSDQGVRLRLRKDSRTVSTKKRTISQADQIRASQGIHGYLAHDANHDLSPNGHHSPHHHLRRLSSLHDQAQLDRSRSYYSESPQMRAGEYTSSSYGYYDDQQHHQKPPHKRPRMDGASPDSPHPSTAGGYETDTTAYHPYAHHHSGPRTVPDPLGSIYPLGTAAGVAVATTTAAGSYQPVPSQPALAGLPMPSPYASMPRLDTTHLPPHSPAGPGSATSTFSPGSRRSPPGTAGSGGGSGGGYAGYAGHGGHGGHHQSHGGQAMYAVTQATSLPYHPAAVHHHHAAAGLGIGIGVGNAEQAGQAGGGGVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PKL8</accession>
    <name>A0AAN6PKL8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phospholipase D1</fullName>
            <ecNumber evidence="3">3.1.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Choline phosphatase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Phosphatidylcholine-hydrolyzing phospholipase D1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">C8A01DRAFT_33289</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14445"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="3.1.4.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the phospholipase D family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.4" evidence="3"/>
    <dbReference type="EMBL" id="MU854338">
        <property type="protein sequence ID" value="KAK4042626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004630">
        <property type="term" value="F:phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01254">
        <property type="entry name" value="PH_PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09138">
        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09141">
        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.870.10:FF:000011">
        <property type="entry name" value="Phospholipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015679">
        <property type="entry name" value="PLipase_D_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896:SF76">
        <property type="entry name" value="PHOSPHOLIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896">
        <property type="entry name" value="PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00614">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="12">
        <location>
            <begin position="894"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="12">
        <location>
            <begin position="1198"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="156"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="268"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="530"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1298"/>
            <end position="1377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1413"/>
            <end position="1481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1570"/>
            <end position="1597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1639"/>
            <end position="1765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="18"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="198"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="219"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="268"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="546"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1332"/>
            <end position="1347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1348"/>
            <end position="1358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1368"/>
            <end position="1377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1570"/>
            <end position="1582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1584"/>
            <end position="1597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1646"/>
            <end position="1665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1666"/>
            <end position="1686"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00074658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00079280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK4042626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1823" mass="203480" checksum="088ED6F0AF64CE0F" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PKU6</accession>
    <name>A0AAN6PKU6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_44199</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854335">
        <property type="protein sequence ID" value="KAK4042843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PKU6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052973">
        <property type="entry name" value="Fungal_sec-metab_reg_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35392:SF2">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35392">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4042843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="741" mass="81623" checksum="1D8A9711C3450DCD" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PL11</accession>
    <name>A0AAN6PL11_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial acidic protein MAM33</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_13446</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854333">
        <property type="protein sequence ID" value="KAK4042969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PL11"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.280.10">
        <property type="entry name" value="Mitochondrial glycoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003428">
        <property type="entry name" value="MAM33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036561">
        <property type="entry name" value="MAM33_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10826">
        <property type="entry name" value="COMPLEMENT COMPONENT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10826:SF1">
        <property type="entry name" value="COMPLEMENT COMPONENT 1 Q SUBCOMPONENT-BINDING PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02330">
        <property type="entry name" value="MAM33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54529">
        <property type="entry name" value="Mitochondrial glycoprotein MAM33-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4042969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="296" mass="32495" checksum="A938AC0E2F4A8EBC" modified="2024-10-02" version="1">MSLRTIARSAPRALARASAASTVSRCQRTSSILSARPSTFLRTQQVSAFSTSLLRRAMAGEVDEEVSAKLASEIEFEKDVKQNEPLPASIQDFLDNSPFKVQDVSGKEDVILTRTFGDEKITVSFSIADLHNDYESDMMEDQAMEDELDDIEAGRNPQGQRNGAADLAEEAGEEGEGGDAAPPCRLNIVIEKPNKGALNIEALAQDGSVVVENLYYYADAKLAHSTDANAVHAAQDAYPGPPFGSLDEDLQILMERYLEERGITQGLALFVPDYMDYKEQKEYMAWLKNVKGFIDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PL60</accession>
    <name>A0AAN6PL60_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Decapping nuclease</fullName>
            <ecNumber evidence="7">3.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_32850</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA. The NAD-cap is present at the 5'-end of some RNAs and snoRNAs. In contrast to the canonical 5'-end N7 methylguanosine (m7G) cap, the NAD cap promotes mRNA decay. Also acts as a non-canonical decapping enzyme that removes the entire cap structure of m7G capped or incompletely capped RNAs. Has decapping activity toward incomplete 5'-end m7G cap mRNAs such as unmethylated 5'-end-capped RNA (cap0), while it has no activity toward 2'-O-ribose methylated m7G cap (cap1). Also possesses RNA 5'-pyrophosphohydrolase activity by hydrolyzing the 5'-end triphosphate to release pyrophosphates. Stimulates exoribonuclease activity of Rat1, allowing it to degrade RNAs with stable secondary structure more effectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside-ribonucleotide in mRNA + H2O = a (N(7)-methyl 5'-triphosphoguanosine)-nucleoside + a 5'-end phospho-ribonucleoside in mRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66928"/>
            <dbReference type="Rhea" id="RHEA-COMP:15692"/>
            <dbReference type="Rhea" id="RHEA-COMP:17313"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:172876"/>
            <dbReference type="ChEBI" id="CHEBI:172877"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:66929"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60880"/>
            <dbReference type="Rhea" id="RHEA-COMP:15692"/>
            <dbReference type="Rhea" id="RHEA-COMP:15698"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:144029"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:60881"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 5'-end triphospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78683"/>
            <dbReference type="Rhea" id="RHEA-COMP:15692"/>
            <dbReference type="Rhea" id="RHEA-COMP:17164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:167618"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:78684"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DXO/Dom3Z family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="7"/>
    <dbReference type="EMBL" id="MU854332">
        <property type="protein sequence ID" value="KAK4043059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PL60"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034353">
        <property type="term" value="F:mRNA 5'-diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110155">
        <property type="term" value="P:NAD-cap decapping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013961">
        <property type="entry name" value="RAI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039039">
        <property type="entry name" value="RAI1-like_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12395:SF9">
        <property type="entry name" value="DECAPPING AND EXORIBONUCLEASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12395">
        <property type="entry name" value="DOM-3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08652">
        <property type="entry name" value="RAI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RAI1-like" evidence="9">
        <location>
            <begin position="21"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="371"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="378"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00046211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4043059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="397" mass="46053" checksum="3ABC04A2FC926712" modified="2024-10-02" version="1">MALTFPVYPPARYAGESEPVKRPKEFACFSYDKNHQFRFNDSSLKWYYPPDIGADLSHGSDTFVKHDDSIDEHLDSLLRTIAFHERKTGEPIDAHVVTWRGMLTKIMATPFDDEGFEMNATLYRDCIFIEEHHAFKQQKKQLENNRGKQRTPPSLMQFWGYKFETLSTIPRPWGETSREYIESRDSEIVNNKEQYCSVVRTGFGKSIVCLGGEVDAIWDAKPETPGDPINWVELKTSAEIRNHNDQFKFDRKLMRYWIQSFLLGVPKIIVGFRTQDGILSKVEEFKTMSLPYDVQRRGMAKWDGNVCIKFTSLFLEWLRLSINDEGVWRIRRQHKSDHIELFKVEEVGHGDIIMDEFMDWRIKLELNKHKPPDVMERPSAGEPAPQSSSESASASGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PL94</accession>
    <name>A0AAN6PL94_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_13289</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854331">
        <property type="protein sequence ID" value="KAK4043128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PL94"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4043128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="528" mass="58325" checksum="53B57B6375A56835" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PLG4</accession>
    <name>A0AAN6PLG4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Concanavalin A-like lectin/glucanase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_43863</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854330">
        <property type="protein sequence ID" value="KAK4043224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PLG4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00413">
        <property type="entry name" value="Glyco_hydrolase_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38121">
        <property type="entry name" value="GH16 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38121:SF4">
        <property type="entry name" value="GH16 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042907331" evidence="2">
        <location>
            <begin position="31"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="370"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="3">
        <location>
            <begin position="36"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4043224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="391" mass="42370" checksum="D7B1FBA8CDC59D62" modified="2024-10-02" version="1">MEPPKRILSLPVSLSSLVLLLSAAAPLAAAEPTLTDDSQCGCYINNDNSSTYFTDHRFFDFRSLSQYAGVPAVIQDLQASPGAAPTSDYFTGTEWTSFWMLGSWNNSNGARSDATVTMANSPNNIYIEANTEANPSSQTYLTLRTQRLNDFQTAAEIESASTSFKYLSLRMRARTVGAAGAITAMFTYRGADALANIQEADLEIRTADPRNLLHYTNQPAYTDGGDVVPEATHNTTMPGGLDWTAWATHRMDWTPGLTTWWVDDEMVAQIAFQAPRDESNIILNAWSDGGKWTGNMTKFDAAYLQVQWLEVVYNSTEAAAASSRKMVRRDGAGGCVAACSVDQTPQLGKPVMLWNNGAAAGMRVNAGGRLVAWVPMGMVLATVLLSTGLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PLW3</accession>
    <name>A0AAN6PLW3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cytochrome P450 monooxygenase ABA1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Abscisic acid biosynthesis protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Cytochrome P450 monooxygenase aba1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">C8A01DRAFT_34442</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Hormone biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854356">
        <property type="protein sequence ID" value="KAK4041489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PLW3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11060">
        <property type="entry name" value="CYP57A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000076">
        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF77">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 16" id="KW-0349">Heme</keyword>
    <keyword evidence="10 16" id="KW-0408">Iron</keyword>
    <keyword evidence="17" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0843">Virulence</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="14"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="16">
        <location>
            <position position="460"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00067672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00068222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00079990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAK4041489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="519" mass="57109" checksum="C8A93F905880A650" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PLW5</accession>
    <name>A0AAN6PLW5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_43564</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854327">
        <property type="protein sequence ID" value="KAK4043434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PLW5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4043434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="372" mass="42318" checksum="F2AEBC3F71A751C6" modified="2024-10-02" version="1">MEVVFAVRASSRRLVLRDPIPSPLKRPANGMGRIKPSLPPPHPPAAFLQLPADIVLYLCQEHLPPASAVALSLICKALFNLVFPRARLGLDMNALERQDLQLVLEKDLGHAWWYCHYCSLLHPISTQGPTSGTRDSYSWMVGWDSSHPYHNRRWLEGSSFSVDYQSVRLAMNRHFRGPLKGLPLESFNVEASSTTLTPWQRKWLPWQERWSARVVQDELFLSATRTLSGAGWTDDSLRAAFDHEWRQICGHVRTSGPAFYSMNTLLRPSPTVFTPYHDLIESCRRCLTDFAITVEQRLEDVKEGCVEEQPTAFWLISITSYQRLGSGRSPMDIQWEAFGNAMTASANRMQRDMSAYPPGAVKAMWESHEPEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PMM6</accession>
    <name>A0AAN6PMM6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_32284</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854326">
        <property type="protein sequence ID" value="KAK4043557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PMM6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4043557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="236" mass="25464" checksum="00708E42BCBC61D9" modified="2024-10-02" version="1">MSFEITKISDLCSICQDDRGTGANGERVPRTAFAAIDAEENAYFGEKSGISIRELTVEMVQEHLRPLPDEEIYPLLPQDENLTVAPYDITNFHVKTRPDLFKGGAIDKDRILSGLSAALDHLHALGLAHNDVNPANVMLAHGGEPVLIDFGSCEPFGERLLSAGTPGWCRAREQAFASDKANDEYGLGLMGPWLDGVVEEVEGSVETGVDWRLELEDVPPLEVKECGGGGGWAGCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PN29</accession>
    <name>A0AAN6PN29_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Ubiquitin-related modifier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">URM1</name>
        <name evidence="7" type="ORF">C8A01DRAFT_13346</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3 homolog UBA4. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as AHP1. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 6">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="5">C-terminal thiocarboxylation occurs in 2 steps, it is first acyl-adenylated (-COAMP) via the hesA/moeB/thiF part of UBA4, then thiocarboxylated (-COSH) via the rhodanese domain of UBA4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the URM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854332">
        <property type="protein sequence ID" value="KAK4043050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PN29"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032447">
        <property type="term" value="P:protein urmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034227">
        <property type="term" value="P:tRNA thio-modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01764">
        <property type="entry name" value="Ubl_Urm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03048">
        <property type="entry name" value="Urm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015221">
        <property type="entry name" value="Urm1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14986">
        <property type="entry name" value="RURM1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09138">
        <property type="entry name" value="Urm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037379">
        <property type="entry name" value="Ubiquitin-related_modifier_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="MoaD/ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="4 5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="modified residue" description="1-thioglycine" evidence="5">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins)" evidence="5">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4043050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="110" mass="12071" checksum="32B98D9DDAD4ABCB" modified="2024-10-02" version="1">MSAATEAAAIPITVDFSGGLEMLFDNQRRHSVSLPAVDASGKPATIAFLIDHLCRTLMKDPRAELFVLDNHIRPGILVLINDADWELEGEEAYEIQPRDNILFVSTLHGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PNH8</accession>
    <name>A0AAN6PNH8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_32747</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854331">
        <property type="protein sequence ID" value="KAK4043108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PNH8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="25"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4043108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="570" mass="62554" checksum="6B9376359ED0B551" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PNK9</accession>
    <name>A0AAN6PNK9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Heterokaryon incompatibility protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_13071</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854328">
        <property type="protein sequence ID" value="KAK4043350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PNK9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF82">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="47"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="438"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4043350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="458" mass="51644" checksum="46112E04DB9490CA" modified="2024-10-02" version="1">MATYPYSPLDLNEPSIRLLHIRKGWWAEDIICQLCEAFADQERGVPYRALSYNWGVLQHKHEAGIPRVIVDGHEIGLTQNLYAALRYIRRPDQDVILWVDAVCINQGDPREKGHQVKQMGNIYKGAEEVLIWLGSGDHDIYSLLESISWIDKKATESVAMGDKGDWTGFCRQFISHRGLNVGSGPKQALARLLTRPWFKRVWILQEVANARTARILCGPSSCPARSFALMPSLMNLAVDQHTQAVLDIMPRVRRQTWWSSDRQLHVLLNKFAGSEALLKRDMIYALLGVSEDACNPATFYPCYEKTNYEVFRDTMSSLLFGEILGSIIPRGLQIPRLPNSRAPNIDLIDLRSPRSLMAVAFLSYHISEGWLDAAGLLLYLTPRYLRDEQISRMLRNKKVDITVGFDTGSDRFVFTITGGSVWRPDAIPVGHRAEIRISPSEPSAETPTTVSDATVPVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PNP4</accession>
    <name>A0AAN6PNP4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Copper-fist domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_42984</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854320">
        <property type="protein sequence ID" value="KAK4044321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PNP4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.430.10:FF:000001">
        <property type="entry name" value="Copper fist DNA-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.430.10">
        <property type="entry name" value="Copper fist DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051763">
        <property type="entry name" value="Copper_Homeo_Regul"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001083">
        <property type="entry name" value="Cu_fist_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036395">
        <property type="entry name" value="Cu_fist_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28088">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR HAA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28088:SF5">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR HAA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00649">
        <property type="entry name" value="Copper-fist"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00617">
        <property type="entry name" value="COPPERFIST"/>
    </dbReference>
    <dbReference type="SMART" id="SM01090">
        <property type="entry name" value="Copper-fist"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00412">
        <property type="entry name" value="Cu_FIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57879">
        <property type="entry name" value="Zinc domain conserved in yeast copper-regulated transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50073">
        <property type="entry name" value="COPPER_FIST_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Copper-fist" evidence="9">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="101"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="145"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="166"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="186"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4044321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="445" mass="48326" checksum="F68BE9EA4E9E6049" modified="2024-10-02" version="1">MLIDGEKWACEACVRGHRVSNCQHHDRPLQHINKKGRPVSQCQHCRAMRKSRSAHTKCDCGEKTHKCVHLRPVIEGHKESCCCNHGGRCTCCSHKREPKLDTVPESDSDEPVPCQSKLSKSSSRARRRANTTNSDAMLSFDANGHHKPTYKHAKASQKCGPYQLTRGHSMTSASSMRNRSMDDLFGAGASADSSSAAGSGDSEGMAHAQRRVKSEAASPLLEPSSFAQLNGQLPPLDLSGIKYPPYIPNSADFFGALSDYEQPMFSAGLSAASVDWSNYEGLELAGKTADFAPSNYSQPQSYGGFDFTGSEHIPTMTTTTSTSGEVSEVEDFLSNPLDDFDTFQNSASINGYDFGQTHASLLGSTDLANLDLDDFSYMKKDPSKFLPTPATMAGDDPTLLTTSTPAFSGLTSLDDDPAFWMNDYSMPTLTESPTESNMASFWDGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PPW7</accession>
    <name>A0AAN6PPW7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Clr5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_13669</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854336">
        <property type="protein sequence ID" value="KAK4042796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PPW7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025676">
        <property type="entry name" value="Clr5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38788">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38788:SF3">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14420">
        <property type="entry name" value="Clr5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Clr5" evidence="2">
        <location>
            <begin position="61"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="180"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4042796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="648" mass="71549" checksum="9B8B6FDDA3A75A4C" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PR91</accession>
    <name>A0AAN6PR91_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein FAM32A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_30954</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854316">
        <property type="protein sequence ID" value="KAK4044775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PR91"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013865">
        <property type="entry name" value="FAM32A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13282">
        <property type="entry name" value="PROTEIN FAM32A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13282:SF6">
        <property type="entry name" value="PROTEIN FAM32A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08555">
        <property type="entry name" value="FAM32A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4044775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="165" mass="18000" checksum="E7174B58648288BE" modified="2024-10-02" version="1">MPADEYTSIARGPLKLKGGAGVTKKKKKKDKDRAKGAGTDLEKNLSTGSGGDRDSAGSALAVSDDAKNTPDERSPDAEDNKGRRGGSEEGRDAKGEGEGQEEEEENKTETERRFAEAKRKRLKELTESGRIRPELLKTHKQRVEELNAHLARLSEHHDMPKIGPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PRP0</accession>
    <name>A0AAN6PRP0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Poly(A) polymerase</fullName>
            <ecNumber evidence="11">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">C8A01DRAFT_31226</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Polymerase that creates the 3'-poly(A) tail of mRNA's.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>RNA(n) + ATP = RNA(n)-3'-adenine ribonucleotide + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11332"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17347"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="ChEBI" id="CHEBI:173115"/>
            <dbReference type="EC" id="2.7.7.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Binds 2 magnesium ions. Also active with manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the poly(A) polymerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="11"/>
    <dbReference type="EMBL" id="MU854317">
        <property type="protein sequence ID" value="KAK4044728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PRP0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.10:FF:000002">
        <property type="entry name" value="Poly(A) polymerase alpha, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1410.10:FF:000001">
        <property type="entry name" value="Putative poly(A) polymerase gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.590">
        <property type="entry name" value="Poly(A) polymerase predicted RNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011068">
        <property type="entry name" value="NuclTrfase_I-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007012">
        <property type="entry name" value="PolA_pol_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048840">
        <property type="entry name" value="PolA_pol_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007010">
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        <property type="entry name" value="POLYNUCLEOTIDE ADENYLYLTRANSFERASE"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <begin position="7"/>
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            <begin position="212"/>
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        </location>
    </feature>
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        <location>
            <begin position="361"/>
            <end position="592"/>
        </location>
    </feature>
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            <begin position="444"/>
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        </location>
    </feature>
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        <location>
            <begin position="579"/>
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        </location>
    </feature>
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        <location>
            <begin position="449"/>
            <end position="487"/>
        </location>
    </feature>
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        <location>
            <begin position="623"/>
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        </location>
    </feature>
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        <location>
            <begin position="100"/>
            <end position="102"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="100"/>
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        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
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    <feature type="binding site" evidence="13">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
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        <location>
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        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
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        <location>
            <position position="157"/>
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        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
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    <feature type="binding site" evidence="13">
        <location>
            <position position="157"/>
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        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
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            <position position="221"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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    <feature type="binding site" evidence="12">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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        <location>
            <begin position="239"/>
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        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010912"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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            <dbReference type="Pfam" id="PF04926"/>
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            <dbReference type="Pfam" id="PF04928"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF20750"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK4044728.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="650" mass="73185" checksum="A7103B91627F1B5F" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PUD9</accession>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_30966</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
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        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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            <end position="25"/>
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            <end position="95"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
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        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="130" mass="13947" checksum="13AC8569A9B4C02B" modified="2024-10-02" version="1">MNTVRSFWLGWGSLCVAGGAAYYFAKQSINADRQSRLQEQRKKKAMVDSLEYSENVPNRPLSSATMGGSTGAVTNGGPPRTDTAGSPSQESSSDPAPTRHAPATEGQRVVEKSKYEASAPFRSTKGDRFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="1">Isoprenoid synthase domain-containing protein</fullName>
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    </protein>
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        <name evidence="1" type="ORF">C8A01DRAFT_41530</name>
    </gene>
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        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
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            <taxon>Pezizomycotina</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854659">
        <property type="protein sequence ID" value="KAK4032036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19086">
        <property type="entry name" value="Terpene_syn_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4032036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="290" mass="32354" checksum="D5765E3CC456074E" modified="2024-10-02" version="1">MESNTKPSAALLGLPNELLDQILAEVKWGAAAPAFDLDGLQFYENLTHNTDTASIQRVRLACRRLASRGSVLLLPVASVSISDPASVDRLEQIAGLGGLAPYVKAVHVYFDFYRADLAADIRLLAMHLMQKGPQLFVESTMLFGMGMTLTPEEDALLADVVRPCYAALALANDYFSFDREWAEIQTNPVGGKPINAVWLYMQWRGLDAPIAKRLVTEAANRYETRFLELCEQFRRQHAPVSPKLDVYLRALSYQVSGNVVWSLNCPRYHPEFRYDPNAGVEDAMTAEQRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SLT5</accession>
    <name>A0AAN6SLT5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fatty acid hydroxylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_41505</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854656">
        <property type="protein sequence ID" value="KAK4032052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SLT5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="175"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4032052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="330" mass="36198" checksum="794F5421829BA042" modified="2024-10-02" version="1" fragment="single">MDILMSLPIISYFFSNTLTSWSTSLNLLFFYLTWSTLVLTHSPVKVEIVGITALRVAFWLVPSLFFLAFDTLLPSLSENIKYNGASALPPRDAKSLAKLAGLALVNLVLETAVEAGLSLGLTTLLKTPVFRTSTTLPLPWQMLKHLALLFTAREVLTYYTHRYLLHGHHPAPSPTLFKRSSSSSTPKPKPLTPPLTSLHTRYAHARPTSPPYALLLKTDHPLPYLLHRFLPLYLPALALHPSNLHILTFLLFAALATLEETLALSGYTVIPGIVMGGMTRRAAVHYAACGRGGGGNFGSWGVLDWVHGTSLGGDVMADLRGEAEKHRVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SLT9</accession>
    <name>A0AAN6SLT9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">C8A01DRAFT_40418</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854550">
        <property type="protein sequence ID" value="KAK4033131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SLT9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090422">
        <property type="term" value="F:thiamine pyrophosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000011">
        <property type="entry name" value="Mitochondrial thiamine pyrophosphate carrier 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 13" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="12"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="122"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="215"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK4033131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="323" mass="35104" checksum="044E0088A07C1C80" modified="2024-10-02" version="1">MSLKGDRLKDEGSRLQVTAAGATAGLIARFVIAPLDVVKIRLQLQTHSLSDPLSHRDLQGGPIYKGTLPTLRHILRAEGITGLWKGNVPAELLYVCYSAVQFTTYRSTTQLLHSSLGEGTLPQSAESFIAGAVGGGIATAATYPLDLLRTRFAAQGNDRVYTSLWRAISQIGREEGVRGFFRGLGPGLAQIIPYMGFFFAAYETLRPHLSGLDLPFSSGGAVAGTMASVMAKTGTFPLDLVRKRIQVQGPTRGRYVHKNIPEYYGGTVGAVRMILRAEGFRGLYRGLTVSLLKAAPASAVTMWTYERALRFYSGFGERREETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SMF7</accession>
    <name>A0AAN6SMF7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Short-chain dehydrogenase/reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_40854</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854582">
        <property type="protein sequence ID" value="KAK4032712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SMF7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF282">
        <property type="entry name" value="WW DOMAIN-CONTAINING OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4032712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="321" mass="34381" checksum="5E2ABD25B1F6794B" modified="2024-10-02" version="1">MFWSNKSVPFNAAKDIPPLDGKVILITGGNVGLGKQAVLEYARHNPRLIWLAARSVQKANAAADEIRLQVPNAPIQVLELDLASFASIKEAAATVLSTSPRLDILMLNAGIMAAPPGLTADGYELQFGTNHMGHALLTKLLLPLLTRTATPDTTNPRPDVRIITLSSHGHVYASKPGIAFPTLKTRAEPMGALGRYYQSKLANVLWARQLARAYPQFTVASIHPGVVQTNLLENAAGAPAVVRAITKVVVGLGLLTPVEQGVRNQLWASVAPVRDGESGVVSGEYYEPVGVAGMGSRDGRDEGLARRLWEWTEGELEGHVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SMW3</accession>
    <name>A0AAN6SMW3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Flap endonuclease 1</fullName>
            <shortName evidence="15">FEN-1</shortName>
            <ecNumber evidence="15">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Flap structure-specific endonuclease 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">C8A01DRAFT_50355</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="15">Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Nucleus</location>
            <location evidence="15">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Nucleus</location>
            <location evidence="15">Nucleoplasm</location>
        </subcellularLocation>
        <text evidence="15">Resides mostly in the nucleoli and relocalizes to the nucleoplasm upon DNA damage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14 15">Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="15"/>
    <dbReference type="EMBL" id="MU854560">
        <property type="protein sequence ID" value="KAK4032985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SMW3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09907">
        <property type="entry name" value="H3TH_FEN1-Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09867">
        <property type="entry name" value="PIN_FEN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000009">
        <property type="entry name" value="Flap endonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000003">
        <property type="entry name" value="Flap endonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00614">
        <property type="entry name" value="Fen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023426">
        <property type="entry name" value="Flap_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019974">
        <property type="entry name" value="XPG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF9">
        <property type="entry name" value="FLAP ENDONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00841">
        <property type="entry name" value="XPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00842">
        <property type="entry name" value="XPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 15" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6 15" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9 15" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="8 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 15" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 15" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="18">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="17">
        <location>
            <begin position="148"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="358"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="358"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="386"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAK4032985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="397" mass="45127" checksum="9777A57F3F0C36E9" modified="2024-10-02" version="1">MGIKQLFSIIKEEAPDAIKEGDIKNQFGRKVAIVIHRSMSIYSFLIAVRSDGQQLMNESGETTSHLMGMFYRTLRMVDNGIKPLYVFDGAPPKLKSGELAKRFQRKQEATEGLEEAKETGTAEDVEKFSRRTVRVTREHNAECQRLLKLMGIPYIVAPTEAEAQCAVLARAGKVYAAASEDMDTLCFNTPILLRHLTFSEQRKEPIQEIHVDKVLEGLNMERKQFVDLCILLGCDYLDPIPKVGPSTALKLIREHGSLEKVVEFMKDDPKARYTVPDDWPFEDARDLFFAPDVRPADDPLCDFKWDKPDMDGLVQFLVHEKGFSEDRVRSAGARLEKNLKSSQQARIEGFFKVLPKTEAEKATHKRKLEEQNEAKKKKLKEEKKEKAKAKAKPRGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SMW4</accession>
    <name>A0AAN6SMW4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_49905</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854524">
        <property type="protein sequence ID" value="KAK4033524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SMW4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42029">
        <property type="entry name" value="AN04G07800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42029:SF3">
        <property type="entry name" value="AN04G07800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="109"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4033524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="343" mass="38186" checksum="E964FE84C424AC99" modified="2024-10-02" version="1">MGRPTDEQIKPSGSGPLTLEAWSQGFMVGALIIMCGITLANMRRGNLLHKLILVELVLALPNGFFIFFDPPAWGWFLSSTVVPLIASWTLHNVIAWMKSKPFLGPRGNLIYIGSVLLVQPYWILEIYANFAYFNGRDSQLFVATRPYEAVFRDPWWIFTIINLFWNIKFRYELGIIEIVQVSPRFGILLLCMTLSVISIIIDLLSVTPVISIGVINPFWKFAFVFKCFTDSIILDDFKASLDKLSLHRRAQILPFSILGGGPAEWGAGGSPGGSPRESRRLKGHGRNRDLDARSSSDIVIDIDISPRSPTPRQTGMELSDVGGLCPPSPAVVHHIEYKTPAGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SN61</accession>
    <name>A0AAN6SN61_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Coatomer subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">C8A01DRAFT_40259</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus membrane</location>
            <topology evidence="1 10">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854540">
        <property type="protein sequence ID" value="KAK4033285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SN61"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22948">
        <property type="entry name" value="Coatomer_WDAD_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.470:FF:000002">
        <property type="entry name" value="Coatomer subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000022">
        <property type="entry name" value="Coatomer subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006692">
        <property type="entry name" value="Beta-prop_COPA/B_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047312">
        <property type="entry name" value="Coatomer_alpha_WD-assoc_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016391">
        <property type="entry name" value="Coatomer_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010714">
        <property type="entry name" value="Coatomer_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050844">
        <property type="entry name" value="Coatomer_complex_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056176">
        <property type="entry name" value="TPR_COPA_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876">
        <property type="entry name" value="COATOMER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876:SF1">
        <property type="entry name" value="COATOMER SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04053">
        <property type="entry name" value="B-prop_COPA_B_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06957">
        <property type="entry name" value="COPI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23953">
        <property type="entry name" value="TPR_COPA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003354">
        <property type="entry name" value="Coatomer_alpha_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50993">
        <property type="entry name" value="Peptidase/esterase 'gauge' domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <keyword evidence="4 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="53"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="95"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="137"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="211"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="255"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B second beta-propeller" evidence="13">
        <location>
            <begin position="350"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B TPR" evidence="15">
        <location>
            <begin position="622"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer alpha subunit C-terminal" evidence="14">
        <location>
            <begin position="848"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="846"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="868"/>
            <end position="878"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR003354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF06957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF23953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK4033285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1218" mass="135835" checksum="D2766664C008D0DA" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SN63</accession>
    <name>A0AAN6SN63_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_38987</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854475">
        <property type="protein sequence ID" value="KAK4034556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SN63"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046536">
        <property type="entry name" value="DUF6601"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34414">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34414:SF1">
        <property type="entry name" value="SUBTILISIN-LIKE SERINE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20246">
        <property type="entry name" value="DUF6601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="281"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="327"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4034556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="381" mass="43909" checksum="45ABCB35C6602C2B" modified="2024-10-02" version="1">MAPVLPPDTNEVAVSPSDTSTPTPAPVNTFTPFDRLALEFNTDLECASVEITEKQTRKILKAKQGRKQYLPGQPRIRLDKPARNVDANNDPLLQYLEKCHSTQGLDELLPWMRYIFVQTPSYTHIMPLHHQKSHAREIKVTENPGLHLVWYYELIFIKPIPAYFYSQAFWEYLENADKKLYSACLGFVRSYYMLIQYDIDFHQACQLRLIPAKGNGELPTYEEWCEFIEPFAKVGDHHVNRRYHYGELRLTRINRAAMLFKFNLAYFHIYPQWGSFLEHTLAPIITIFAVCSVVLNSMQVSLGVLQLKNDMDMMPAAWFPFVDASQWFPVVVMLSIAVILISALFGMGIMGLKDLDRGNRVRERKKSGDPNAGTRSHGMVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SNP8</accession>
    <name>A0AAN6SNP8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_49468</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854497">
        <property type="protein sequence ID" value="KAK4034047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SNP8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08946">
        <property type="entry name" value="SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43000">
        <property type="entry name" value="DTDP-D-GLUCOSE 4,6-DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="2">
        <location>
            <begin position="6"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4034047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="346" mass="37448" checksum="D18B24A521BB6139" modified="2024-10-02" version="1">MSKPTVLVTGSAGHLGKALMLALPELGYSPIGIDITPGPTTTYTGSITDTALLTSLFTTHQPAHVIHAATLHKPHVDSHTKNDFIQTNIAGTLALLEAATTTTTCTSTVKSFTFISTTSTFGSALSPAPGQPAAWIDESVVPQPKNIYGVTKTAAEDVCRLVHKQTGLPVIVLRTSRFFPEEDDDAERRGAMDGENLKVLELAYRRVDIADVVAACVCAMEKGGKGEVVWGKYIVSAPAPFGKDEVTLRGLDEDAGMVFKGVVPGVAEVFEKKGWRLLERVDRVYDSGRAVRELGWRPEYTFEKAVERVGRGEEWRSELTLKVGKLGYHAVSTGVYTTREETRLGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SNV4</accession>
    <name>A0AAN6SNV4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">arginine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Arginyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">C8A01DRAFT_18938</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Arg) + L-arginine + ATP = L-arginyl-tRNA(Arg) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20301"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.19"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.19" evidence="2"/>
    <dbReference type="EMBL" id="MU854489">
        <property type="protein sequence ID" value="KAK4034212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SNV4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07956">
        <property type="entry name" value="Anticodon_Ia_Arg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000006">
        <property type="entry name" value="Arginyl-tRNA synthetase 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000058">
        <property type="entry name" value="Mitochondrial arginyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.70">
        <property type="entry name" value="Arginyl tRNA synthetase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001278">
        <property type="entry name" value="Arg-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036695">
        <property type="entry name" value="Arg-tRNA-synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035684">
        <property type="entry name" value="ArgRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008909">
        <property type="entry name" value="DALR_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00456">
        <property type="entry name" value="argS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956:SF11">
        <property type="entry name" value="ARGININE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956">
        <property type="entry name" value="ARGINYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05746">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00750">
        <property type="entry name" value="tRNA-synt_1d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01038">
        <property type="entry name" value="TRNASYNTHARG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00836">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55190">
        <property type="entry name" value="Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DALR anticodon binding" evidence="11">
        <location>
            <begin position="513"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK4034212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="655" mass="72948" checksum="F632498B475FF1C4" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SPJ9</accession>
    <name>A0AAN6SPJ9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sac2 family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_17964</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS52 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854446">
        <property type="protein sequence ID" value="KAK4035369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SPJ9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007258">
        <property type="entry name" value="Vps52"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048361">
        <property type="entry name" value="Vps52_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048319">
        <property type="entry name" value="Vps52_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14190">
        <property type="entry name" value="SUPPRESSOR OF ACTIN MUTATIONS 2/VACUOLAR PROTEIN SORTING 52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14190:SF7">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 52 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20655">
        <property type="entry name" value="Vps52_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04129">
        <property type="entry name" value="Vps52_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vps52 coiled-coil" evidence="7">
        <location>
            <begin position="180"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="Vps52 C-terminal" evidence="8">
        <location>
            <begin position="362"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="19"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="44"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="70"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4035369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="687" mass="75633" checksum="785983D4871A2FCC" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SPZ7</accession>
    <name>A0AAN6SPZ7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_38198</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854447">
        <property type="protein sequence ID" value="KAK4035353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SPZ7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051704">
        <property type="entry name" value="FAD_aromatic-hydroxylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46865:SF2">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46865">
        <property type="entry name" value="OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="7"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4035353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="430" mass="46730" checksum="8C6D953AD900C3E1" modified="2024-10-02" version="1">MSKDQLRVLIVGASIAGPATAYWFAKGGARVTVIERFPQMRTNGQNIDIRTVGVTVMRKMPGMEAAVRAKAVPLSGISFVNTHGRPFATIRATGNPDQQSLVSEFEILRGDLSQILFDMTSRDKNITYIFGEQVASIQQQSVLEDGPVTVTFTNGLLPTQDFDLIVAADGAASRTRALGLACRVREHMNPVNIWAAYFSIPHNLLPSNSKLGQAHNAPGGRFIALGPHSTPDTTQVTMMRTYPRHDTASMLPFREAQKRGDDTLKSFVADQFRGAGWKCDDIITAMMDDAQDFYASEIVQVKTPHLYNGRVVLVGDAGYAAGPTGGGTSLALTGAYVLAGEVCCRHKGDLGGALKGYEAVMRPVVGELQKIPWGLQEVMAPQTGWGLRVRNGVLWVVCCWAGVLGVVQRWFARAFGEREEGGLPEYEWVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SQA1</accession>
    <name>A0AAN6SQA1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_37401</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854423">
        <property type="protein sequence ID" value="KAK4038632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SQA1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="131"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4038632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="205" mass="23414" checksum="FE2CBDA8224474E8" modified="2024-10-02" version="1">MAGMSHEELNRWLDGRLQPLEVRVKKYIEVEAKAEVKTQLYAEFKAFARSCRDSIKADLMQGNSGLRRAPQNTIESALQKIGNDCRSDINTLKTQETSLRRRIGSVEKSFRKLRKKGAYDDVPAAPPRPFKPSNNERIAALEEENRKLRQENEQLRQEIQGVVERHDARDDQHAAQIEQLVEQQKAIMQQLSQAGLVAADRVVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SQE3</accession>
    <name>A0AAN6SQE3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein-lysine N-methyltransferase EFM6</fullName>
            <ecNumber evidence="1">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Elongation factor methyltransferase 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">EFM6</name>
        <name evidence="2" type="ORF">C8A01DRAFT_37615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that methylates elongation factor 1-alpha.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. METTL21 family. EFM6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="MU854429">
        <property type="protein sequence ID" value="KAK4038435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SQE3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03198">
        <property type="entry name" value="Methyltr_EFM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033684">
        <property type="entry name" value="EFM6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF152">
        <property type="entry name" value="PROTEIN-LYSINE N-METHYLTRANSFERASE EFM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="87"/>
            <end position="89"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4038435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="235" mass="26344" checksum="C87C1D56C740643A" modified="2024-10-02" version="1">MTDKERSSSPEFSPFAFGEDFAPLPEYKTAGTTQVDFSGLLGEPLKLHEDLKAGCGGQLWPAGMVLAKHMLRYHKDRLQHARILELGAGGGVVGLTVARGCSSLDHPLYLTDMVEMESLMQHNISLNGLDDRARARVLNWGEPLSQEVLDFKPDTILAADCVYFEPAFPLLMQTLQDLLTAVPSATVFFCFKKRRRADMQFLKAARKAFTVIEIEDEDRPVFSRDGLFLYTFTHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SQF4</accession>
    <name>A0AAN6SQF4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_17137</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854418">
        <property type="protein sequence ID" value="KAK4038797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SQF4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF161">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="33"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="324"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="331"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4038797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="377" mass="41221" checksum="44009FDC6E54CF02" modified="2024-10-02" version="1">MFDFVEFPVLPIVKVHLIINCALAFLTVAVVALRLVSRFTSGAGLWWDDYLIMFALPQGIGMLVIQGLWSPMGIGFDVTETLPNLETILKMLVAYELIYATSISTIKLSVMFFYLRVFVNRGLRMATKAALIFVSLWSVGNILQVFLICRPFVKTYSLTAEGVCGDQVASFIAIGAFNIISDVIILTLPLPTVWSLKISTPAKLGLTGVFLVGLVVSVIGVIRIVTLTQLDLTNLTSTMIWADFWSATEPNLAILCVSLPMLGSLWSRCVATRRGASKLAYHSSENGTHGSAFSKLKNQGHTDPQIPLEELYAANQEVHYQSAVATAGTPEPDRDTAADVEKDKDSGSDVALTEQAPYQTDPKSGIRVQTKWTISHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SQK5</accession>
    <name>A0AAN6SQK5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_17418</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854427">
        <property type="protein sequence ID" value="KAK4038496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SQK5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="1">
        <location>
            <begin position="21"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4038496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="326" mass="35967" checksum="9147140FE7B15578" modified="2024-10-02" version="1" fragment="single">LRMDKLLQMPTTTATGFPIMALPRELRDKIWEECFWLIRTGPLHPPCSPFPKHSVVLRDPNRNGVSLGTGHHAPFYTRQAPPIALVCRESREVARRTWSKGQKEGKPLWEHECTVPVLQQIDTARTDSSITLLAIHPPENHLVLDLRSELRPAYGGGTSPLASSVHGARLLDLVLAAKDDQIKVLLPETQTFCLPYGPGTPPLPPAAQGWLSETRRLVSVNDVGAWEELGGIAAHYGLPWPFADTVLGGLLSRAKLVADAVRPLQSLWERESARRKHANMGRLKPLPRIDAVTYVEVSRGGTIGMLGFKGVPDRAALRELLDYGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SR58</accession>
    <name>A0AAN6SR58_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alpha-galactosidase a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_46598</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854386">
        <property type="protein sequence ID" value="KAK4040024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SR58"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4040024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="242" mass="27483" checksum="1B4F1F1B43D8391C" modified="2024-10-02" version="1">MSIPSPVVNSHVQLLAALVDFDDKEESEYRFLVDGRHVKYVTVDPGVLPKDDRTFAPVLLPLLPPFPLGDWNEGHISKDAQNGRPVFANVNKSSLPGVKNTWHPTLIDHLELRKLDRLRQNIHKVAHPRFDEPVLVKFAEFPWQIPYLEDETTVYQWIDGSGIGPKFLGHVTEEGRVIGFVMEYIDGARTATPDDLRACQRALSRLHALGIKHGDINKHNFVAAERDRTRVELDVEYSRLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SRG9</accession>
    <name>A0AAN6SRG9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycosyl hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_36459</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854397">
        <property type="protein sequence ID" value="KAK4039590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SRG9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18619">
        <property type="entry name" value="GH43_CoXyl43_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052176">
        <property type="entry name" value="Glycosyl_Hydrlase_43_Enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43772">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43772:SF2">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G04480)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="5">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4039590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="327" mass="37063" checksum="59E7AE1BCB328ED0" modified="2024-10-02" version="1">MAPLITSMYTADPSAHVFEGKVYIYPSHDRETDIQFNDNGDQYDMADYHVFSTDSLDPAAPVTDHGVVLKTEDVPWVSKQLWAPDAAYKDGKYYLYFPARDKEGIFRVGVAVGDRPEGPFTPDPEPIKGSYSIDPATFVDEDDQAYMYFGGLWGGQLQCYQKGNDLFDAAWQGPKEPSGEGVPALGPRVAKMTDDMRQFATEVKEIEILAPETGKPILADDHDRRFFEAAWMHKYNGKYYFSYSTGDTHYLAYATGDSPYGPFTYGGRILEPVLGWTTHHSIVEFKGRWWLFHHDCELSKGVDHLRSVKVKEIFYDKDGKIVTEKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SRS0</accession>
    <name>A0AAN6SRS0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_16330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854393">
        <property type="protein sequence ID" value="KAK4039726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SRS0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4039726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="140" mass="15145" checksum="91AAEED293EEF0A1" modified="2024-10-02" version="1" fragment="single">MVASPVLPGNAELSLLEHSLEEICKEFPLFDTREFLDRVRSQGAASMEACGSASRWACVNAAIALSVHAKTVNGAFEELSPFAWGYFKNAYAAFPELMLQGNDSETVKALVLMALFGRNSADARTTSLLLSTALRLSQTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SRT8</accession>
    <name>A0AAN6SRT8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_16291</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854392">
        <property type="protein sequence ID" value="KAK4039786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SRT8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="462"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4039786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="513" mass="56107" checksum="E07D1D0829E97650" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SS56</accession>
    <name>A0AAN6SS56_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Heavy-metal-associated domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_15771</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the ATX1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854379">
        <property type="protein sequence ID" value="KAK4040325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SS56"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016531">
        <property type="term" value="F:copper chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006825">
        <property type="term" value="P:copper ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000008">
        <property type="entry name" value="Copper transport protein ATOX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051881">
        <property type="entry name" value="Copper_transport_ATOX1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46365">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN ATOX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46365:SF1">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN ATOX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="3" id="KW-0187">Copper transport</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="HMA" evidence="8">
        <location>
            <begin position="16"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4040325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="97" mass="10049" checksum="20CCC2E97D297BDF" modified="2024-10-02" version="1">MADAGASAPAPDAVVEHKYQFNVSMSCGGCSGAVDRVLKKLEGVKSYEVSLDTQTATVVADESLSYEKVLRTIAKTGKKVNSGDADGIAQSVEVPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SSD0</accession>
    <name>A0AAN6SSD0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cysteine-rich transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_35594</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endomembrane system</location>
            <topology evidence="6">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CYSTM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854378">
        <property type="protein sequence ID" value="KAK4040356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SSD0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010038">
        <property type="term" value="P:response to metal ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051671">
        <property type="entry name" value="CYSTM1_HM_Tolerance"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028144">
        <property type="entry name" value="CYSTM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35470">
        <property type="entry name" value="CADMIUM TOLERANT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35470:SF6">
        <property type="entry name" value="PROTEIN CYSTEINE-RICH TRANSMEMBRANE MODULE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12734">
        <property type="entry name" value="CYSTM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Cysteine-rich transmembrane" evidence="8">
        <location>
            <begin position="58"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="49"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4040356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="111" mass="11833" checksum="5863D7E58AC0DC2F" modified="2024-10-02" version="1">MSYPSPQGGYPPQQGYGSPPQGYGSPPPQGYGSPPPQGYGSPPQGYAPQPYPPPGGGYPPPQQQMHYQEAHPPPKEEKSHGCFYTCIAALCCCWVCGETCECCLECLDCCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SSJ7</accession>
    <name>A0AAN6SSJ7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ketoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_14718</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854355">
        <property type="protein sequence ID" value="KAK4041539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SSJ7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43669">
        <property type="entry name" value="5-KETO-D-GLUCONATE 5-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43669:SF15">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_1G01330)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="4">
        <location>
            <begin position="6"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4041539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="262" mass="28881" checksum="C7B5013FB6AB46F1" modified="2024-10-02" version="1">MAFNYKRVLLVGATSGIGAAMADKLVLEGAKVIAVGRRQERLDAFVQKHGPEKASGVRYDITDTAGMDAFIERIVTDYPDLDCVFLNAGRQHQVRLSRPAEVDLDAFHAEMGTNFSRLVDLSVKFLPHLLQKPFPTALVVTGSLIAAVPAVAVPAYSASKAALNAFVCCLRRQYRGTNTRIIEVWPPLVQTEIHDYMGPEIGRAMGMPVSEFTDKAWAQLAAGNELVIVGSMGPEERFLEMVRMREKAFEDLSDLMLAHFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6ST20</accession>
    <name>A0AAN6ST20_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Actin-like ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_34761</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854361">
        <property type="protein sequence ID" value="KAK4041240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6ST20"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10170">
        <property type="entry name" value="ASKHA_NBD_HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF5">
        <property type="entry name" value="HEAT SHOCK 70 KDA PROTEIN 12A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4041240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="544" mass="59582" checksum="E9E1FDBFEE6860F0" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6STJ1</accession>
    <name>A0AAN6STJ1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_14808</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854357">
        <property type="protein sequence ID" value="KAK4041468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6STJ1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17352">
        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF234">
        <property type="entry name" value="MFS-TYPE TRANSPORTER DBAD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="141"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="271"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="308"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="363"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="400"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="434"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="69"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4041468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="464" mass="49230" checksum="94047613EAB905EE" modified="2024-10-02" version="1">MEKDTEKLAYTSESDRTEGEPSIRSPDDMPDDKAAEATTATATPAAVAAAAPADPERPLPDQIPDGGLTAWLQVVGSAAVLVNTWGIINSFGVFQAYYEADLLRSHSSSDISWIGSTQAALLFLVGVVAGPLYDAGYFRQLLLVGLFLIVFGQFMTSLCTAYWQVMLAQGIAMGIGMGLTFLPSAAILGQYFARHRALVLGLSSVGSPVAGSVFPILFSRLEPRVGFGWATRAVAFILLAVSAVPIVFMRTRLPPTARRRAFIDRSALRDAPYLMFVVGSTFAFLTLYVTFFYISLFAKSHGVADESFAPYLVTLLNVGSILGRVIPNALADRYGSVNLLIVCSVGSAVLVFGWLGISNLGGGVVYVLLYGAFSGGVVSLTPSVIAGLSPDMGRVGARMGMCFVIAGISLLVGTPIAGAILGSGGDEPQWLGTILYAAFGLLVATAFYCASRFWLYKRNGDWKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SUE2</accession>
    <name>A0AAN6SUE2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_44575</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854341">
        <property type="protein sequence ID" value="KAK4042443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SUE2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="3">
        <location>
            <begin position="129"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="453"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="46"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="533"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4042443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="554" mass="60383" checksum="C2FDE40462049187" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SUG8</accession>
    <name>A0AAN6SUG8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Membrane bound O-acyl transferase family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_13465</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the wax synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854333">
        <property type="protein sequence ID" value="KAK4043012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SUG8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044851">
        <property type="entry name" value="Wax_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032805">
        <property type="entry name" value="Wax_synthase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31595">
        <property type="entry name" value="LONG-CHAIN-ALCOHOL O-FATTY-ACYLTRANSFERASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31595:SF67">
        <property type="entry name" value="WAX SYNTHASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13813">
        <property type="entry name" value="MBOAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="410"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="443"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="486"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="Wax synthase" evidence="8">
        <location>
            <begin position="349"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4043012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="560" mass="61673" checksum="D5032B69CA91910F" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SV27</accession>
    <name>A0AAN6SV27_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosome production factor 2 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Ribosome biogenesis protein RPF2 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_32199</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
            <location evidence="1 4">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the RPF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854325">
        <property type="protein sequence ID" value="KAK4043672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SV27"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039770">
        <property type="entry name" value="Rpf2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12728">
        <property type="entry name" value="BRIX DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12728:SF0">
        <property type="entry name" value="RIBOSOME PRODUCTION FACTOR 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="6">
        <location>
            <begin position="28"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="296"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4043672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="334" mass="37989" checksum="DA016418F63495FC" modified="2024-10-02" version="1">MLRQIKPRNARSKRALEKRAPKAVENPKSALILRGTSCSQVTQDALGDLYALRQVHAKRFQKKNPVHPFEDASSLAFFSEKNDCSLLLFGSSSKKRPHTITFARTFDYKILDMLEFCLDGDTFRSLAQFKTEKVPVGTRPLMVFAGTAFESTVPNGFTMAKSMLIDFFRGEVSDKIDVEGLRYVVVVTADEPTSTTTNDDDPASKPVLRLRVYTIRTQRSGQKLPRVELEEHGPRMDFRLGRVQEADEALLKEAMRRAKTGEERTRKNVTTDVMGDKIGRIHTGKLDLSELQTRKMKGLKRERDQHLDDDEDEEKTVVAEEAEQQPKRKRRGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SVB9</accession>
    <name>A0AAN6SVB9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">mevalonate kinase</fullName>
            <ecNumber evidence="3">2.7.1.36</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Ergosterol biosynthesis protein 12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">C8A01DRAFT_43601</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>(R)-mevalonate + ATP = (R)-5-phosphomevalonate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17065"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:36464"/>
            <dbReference type="ChEBI" id="CHEBI:58146"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.36"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:17066"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="18">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GHMP kinase family. Mevalonate kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.36" evidence="3"/>
    <dbReference type="EMBL" id="MU854327">
        <property type="protein sequence ID" value="KAK4043476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SVB9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004496">
        <property type="term" value="F:mevalonate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008318">
        <property type="term" value="F:protein prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000027">
        <property type="entry name" value="Mevalonate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.890:FF:000003">
        <property type="entry name" value="Mevalonate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.120">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006205">
        <property type="entry name" value="Mev_gal_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002088">
        <property type="entry name" value="Prenyl_trans_a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00549">
        <property type="entry name" value="mevalon_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43290">
        <property type="entry name" value="MEVALONATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43290:SF2">
        <property type="entry name" value="MEVALONATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01239">
        <property type="entry name" value="PPTA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00959">
        <property type="entry name" value="MEVGALKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48439">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51147">
        <property type="entry name" value="PFTA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="16" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="13" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="15" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="21">
        <location>
            <begin position="200"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase C-terminal" evidence="22">
        <location>
            <begin position="372"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="492"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="589"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="30"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="20">
        <location>
            <begin position="56"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="499"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="589"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00029310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00029438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00084043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KAK4043476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1063" mass="116309" checksum="A53EBE70C4C4DB87" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SVF5</accession>
    <name>A0AAN6SVF5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Calcium channel YVC1-like C-terminal transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_12402</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854321">
        <property type="protein sequence ID" value="KAK4044062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SVF5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052971">
        <property type="entry name" value="TRP_calcium_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056336">
        <property type="entry name" value="YVC1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859:SF5">
        <property type="entry name" value="ION TRANSPORT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859">
        <property type="entry name" value="NONSELECTIVE CATION CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23317">
        <property type="entry name" value="YVC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="347"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="383"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="426"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="454"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="485"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="Calcium channel YVC1-like C-terminal transmembrane" evidence="4">
        <location>
            <begin position="300"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="602"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="695"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="623"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4044062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="737" mass="82155" checksum="1D0940E5649BFB91" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SVN8</accession>
    <name>A0AAN6SVN8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">leucine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Leucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">C8A01DRAFT_11778</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Leu) + L-leucine + ATP = L-leucyl-tRNA(Leu) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11688"/>
            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:9622"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78494"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.4" evidence="2"/>
    <dbReference type="EMBL" id="MU854316">
        <property type="protein sequence ID" value="KAK4044809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SVN8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004823">
        <property type="term" value="F:leucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006429">
        <property type="term" value="P:leucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00812">
        <property type="entry name" value="LeuRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000002">
        <property type="entry name" value="Leucine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000003">
        <property type="entry name" value="Leucine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000338">
        <property type="entry name" value="Leucine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00049_B">
        <property type="entry name" value="Leu_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002302">
        <property type="entry name" value="Leu-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025709">
        <property type="entry name" value="Leu_tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00396">
        <property type="entry name" value="leuS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43740:SF2">
        <property type="entry name" value="LEUCINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43740">
        <property type="entry name" value="LEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13603">
        <property type="entry name" value="tRNA-synt_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00985">
        <property type="entry name" value="TRNASYNTHLEU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methionyl/Leucyl tRNA synthetase" evidence="13">
        <location>
            <begin position="92"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Leucyl-tRNA synthetase editing" evidence="14">
        <location>
            <begin position="277"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="11">
        <location>
            <begin position="484"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="11">
        <location>
            <begin position="688"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="12">
        <location>
            <begin position="792"/>
            <end position="918"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF13603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK4044809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="971" mass="107155" checksum="F03DC76436E4AE0D" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SVP3</accession>
    <name>A0AAN6SVP3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sin3 associated polypeptide p18-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_31843</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SAP18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854322">
        <property type="protein sequence ID" value="KAK4043970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SVP3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.550">
        <property type="entry name" value="ASAP complex, SAP18 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010516">
        <property type="entry name" value="SAP18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042534">
        <property type="entry name" value="SAP18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13082:SF0">
        <property type="entry name" value="HISTONE DEACETYLASE COMPLEX SUBUNIT SAP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13082">
        <property type="entry name" value="SAP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06487">
        <property type="entry name" value="SAP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="178"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="202"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="241"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4043970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="263" mass="27898" checksum="1E103CBFF451E431" modified="2024-10-02" version="1">MSPPELNRDETPPFLMKLFYRTGAFHRPDEFNTPSSLPPHLPIHTWTDCTLSELSDHILDASPPILPDPATGTRLSFCLIYADTRGAARMDAPPRYVSKVLGTVVLGRGGPGAGPEEGVPDGETDDGALTLAEARFITGDFICCAILPPDELTGHVAPASSARIGRGAGVGEARGQMMGGNAQPPQPPPFFSGGSRQRDYGPPGGFRGRGSRGGGSRGGYGGGGRFQERDEPFGRGGVRIPDGEWRRGDRLPDDPPEGGRWGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P3Y0</accession>
    <name>A0AAN6P3Y0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_21499</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854931">
        <property type="protein sequence ID" value="KAK4031254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P3Y0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4031254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="80" mass="8916" checksum="528CFC20B60FA1A3" modified="2024-10-02" version="1" fragment="single">VTGDSEESYIYCETLEKIGYILVKEYNLEANRDNSENKKEGTTYYISSTKYSPGISANPGEPSTEVYFDIGSNTNLADKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P4L2</accession>
    <name>A0AAN6P4L2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_21157</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854732">
        <property type="protein sequence ID" value="KAK4031669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P4L2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4031669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="106" mass="12248" checksum="DDF5CD333EC6D864" modified="2024-10-02" version="1" fragment="single">DRPPTPSSIDIAIGRRNGLTIALDITQNTLQESKTRPTPSLKEMIETLSKENGRLREELVYYCNLQKLIEELRQEVNYATNRLNIAVYNFQKGYTDLWREFEGVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P5K2</accession>
    <name>A0AAN6P5K2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleoside phosphorylase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_42347</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU855084">
        <property type="protein sequence ID" value="KAK4031160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P5K2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF6">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4031160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="282" mass="30294" checksum="6101CB22BED2EE36" modified="2024-10-02" version="1" fragment="single">DDDGPPYDKAAGDPNAYSTGAVGRHNVVLAHMPGIGKASAAAVAANCRASFPNIKLALIVGVCGVVPFRPGSSGETAETVLGNVIFVPKDTLLDVLGRPNTGIPALLAKLKGLRSRKMLQGKMAGYIDVLYSEPELAATYPGITQDKLFKATYRHIRDGMSYEECAYDGELVPRTCLEQGDRQPTVHFSLIASGDTVMKSGKDRDDIAREAGVIGFEMESAGVWDIFPCVVIKGACDYADSLEEWPLGNAVLQRITMDGSPPTFSMEQEERQTRLSEEPESP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P5N8</accession>
    <name>A0AAN6P5N8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Plasma membrane fusion protein PRM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">C8A01DRAFT_20689</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Involved in cell fusion during mating by stabilizing the plasma membrane fusion event.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cell membrane</location>
            <topology evidence="2 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the PRM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854634">
        <property type="protein sequence ID" value="KAK4032221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P5N8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032220">
        <property type="term" value="P:plasma membrane fusion involved in cytogamy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026777">
        <property type="entry name" value="PRM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31030">
        <property type="entry name" value="PLASMA MEMBRANE FUSION PROTEIN PRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31030:SF1">
        <property type="entry name" value="PLASMA MEMBRANE FUSION PROTEIN PRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0184">Conjugation</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="328"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="400"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="611"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="640"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="654"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="707"/>
            <end position="716"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK4032221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="716" mass="77817" checksum="0AF6A1BF909130D9" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P6A7</accession>
    <name>A0AAN6P6A7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Mur ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_20459</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the folylpolyglutamate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854607">
        <property type="protein sequence ID" value="KAK4032469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P6A7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="entry name" value="Mur-like, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001645">
        <property type="entry name" value="Folylpolyglutamate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136:SF5">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="MurD-like peptide ligases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4032469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="72" mass="8203" checksum="CD128DEE2B089F9A" modified="2024-10-02" version="1" fragment="single">SGLNVIHITGTKGKGSIAAFTDSLIHTYFHRLSRPVKVGLYISPYLITERERIRINFEPLSEEIFAGYFFDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P6Q9</accession>
    <name>A0AAN6P6Q9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_41761</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854701">
        <property type="protein sequence ID" value="KAK4031790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P6Q9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39599:SF2">
        <property type="entry name" value="ANCHORED PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G09650)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39599">
        <property type="entry name" value="GPI-ANCHORED PROTEIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042949937" evidence="2">
        <location>
            <begin position="19"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="280"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4031790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="326" mass="33490" checksum="E7835386F93C8360" modified="2024-10-02" version="1">MRPLPLSLWLLVTAQIEAREQAQADSQHLLPTAVRKMPADQGAKFHHEYCAFGDHSAFAPASHKPLAAIAARSVHDSDDARRIWANASAELPLRPPFALLSGPEYQDESTPPAWDLFRRAASALAFLEQRQWACPSGTTSCSSMGFPNSCCGTGETCMEVPDTGLGPVGCCPSGATCGGGISTCADGSTACGSNIGGGCCIPGFVCQGVGCVRSAPSPSPTPTTLTTTSTSIISAPTPSTILVTVIITIPPSTSPPAITSTVIQTTTASISNGAGAPFRPTSSPSSQSPSPSDTNTASYCPTGFYPCLARAGGGTAPRHLVHQDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P857</accession>
    <name>A0AAN6P857_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycogen [starch] synthase</fullName>
            <ecNumber evidence="8">2.4.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_19611</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Glycogen synthase participates in the glycogen biosynthetic process along with glycogenin and glycogen branching enzyme. Extends the primer composed of a few glucose units formed by glycogenin by adding new glucose units to it. In this context, glycogen synthase transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose = [(1-&gt;4)-alpha-D-glucosyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18549"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9587"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.11"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:18550"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyltransferase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.11" evidence="8"/>
    <dbReference type="EMBL" id="MU854530">
        <property type="protein sequence ID" value="KAK4033445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P857"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004373">
        <property type="term" value="F:alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03793">
        <property type="entry name" value="GT3_GSY2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000014">
        <property type="entry name" value="Glycogen [starch] synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000045">
        <property type="entry name" value="Glycogen [starch] synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008631">
        <property type="entry name" value="Glycogen_synth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10176:SF3">
        <property type="entry name" value="GLYCOGEN [STARCH] SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10176">
        <property type="entry name" value="GLYCOGEN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05693">
        <property type="entry name" value="Glycogen_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="3 8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="676"/>
            <end position="710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00043883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4033445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="710" mass="80833" checksum="C1E9ADEADC3EA9A5" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P8E1</accession>
    <name>A0AAN6P8E1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Autophagy-related protein 17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_40923</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Autophagy-specific protein that functions in response to autophagy-inducing signals as a scaffold to recruit other ATG proteins to organize preautophagosomal structure (PAS) formation. Modulates the timing and magnitude of the autophagy response, such as the size of the sequestering vesicles. Plays particularly a role in pexophagy and nucleophagy.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Preautophagosomal structure membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ATG17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854588">
        <property type="protein sequence ID" value="KAK4032645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P8E1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990316">
        <property type="term" value="C:Atg1/ULK1 kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030295">
        <property type="term" value="F:protein kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007240">
        <property type="entry name" value="Atg17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045326">
        <property type="entry name" value="ATG17-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28005">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28005:SF1">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04108">
        <property type="entry name" value="ATG17_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0072">Autophagy</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Autophagy protein ATG17-like" evidence="9">
        <location>
            <begin position="47"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="472"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="314"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="415"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4032645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="498" mass="55312" checksum="47E864161767A6AA" modified="2024-10-02" version="1">MATSRPASAASPRSRPTSYHDPPSPDFGADDVPVEVLVRHLLAAKQSLSSMALVLRANDLATHARQMHEESVVLAAQTAFLRRLIDEEVLLLRKLRRGMGHAYDHGQREFGQLVRTLDAANEKLLKTMDMLRDTRVEPVFRPPGEDAKCLMDFVDENSVKVMQDTLMGNIGELQAAQTSFDGDLLRFDHDLRLLHKTLTAAPSPDSPSSSAAYQPIPHLLAALAEHSEAMAQHLTSLTTHFDMCVKAVRATEGGAALARRRAAEAADDGEPVSISGVITEQESHLTDLEPMDPQELAEIVQVVVEDAPEVDEVVAEIQAALQQMEHEFGALKEQADRVRAVWAATLGAFQVLEEIEGRLQGYVAAEHEFEQRWEAEKDVIFDKLEEINGLKRFYEGYASAYSSLLLEVERRRAVEDRIQNTLRKARDNVENLVEADRKQREHFRQEVGEFLPTDLWVGMNNPLKRWELAPMQAGGESQEELTTPTVANAVGGKAPAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P8J0</accession>
    <name>A0AAN6P8J0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Histidine phosphatase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_39822</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854513">
        <property type="protein sequence ID" value="KAK4033736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P8J0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF24">
        <property type="entry name" value="PHOSPHOGLYCERATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4033736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="228" mass="25308" checksum="961B7B4D4FD9EB3C" modified="2024-10-02" version="1">MPPTLVLIRHAQAIHNVDRANHFFPDPSLTDLGRQQSAELREHLKAHLPADREMQLIVVSPMRRAVQTCLIALDWLIDSGVPVVPDARWQENYPKPCDTGSPAPELAAEFPGIDFSGLDPVYPDKTSPAGAAYRYEKGAILARGQSALADLYKRTEDVILVVSHSGFMRTAVAGQWFHNADYRIFDFVDREGKGEDEPYKLVEWALTRGKGGMGRSNEVVVEFGEGLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P8P3</accession>
    <name>A0AAN6P8P3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_20145</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854571">
        <property type="protein sequence ID" value="KAK4032842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P8P3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4032842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="57" mass="6306" checksum="D5C4CDE1BB2DB316" modified="2024-10-02" version="1" fragment="single">EKPCDARKSPNILVDGVADGAGEAARRRPRSPFDHFFYNFCVIGPNESAKILVPKTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P8S8</accession>
    <name>A0AAN6P8S8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nucleophile aminohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_39692</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854507">
        <property type="protein sequence ID" value="KAK4033844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P8S8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061672">
        <property type="term" value="C:glutathione hydrolase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008242">
        <property type="term" value="F:omega peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01908">
        <property type="entry name" value="YafJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000045">
        <property type="entry name" value="Glutamine amidotransferase DUG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026869">
        <property type="entry name" value="EgtC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052373">
        <property type="entry name" value="Gamma-glu_amide_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43187">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE DUG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43187:SF1">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE DUG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13230">
        <property type="entry name" value="GATase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="3">
        <location>
            <begin position="2"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="366"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="373"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4033844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="504" mass="55275" checksum="F5FB3865BE039949" modified="2024-10-02" version="1">MCRFLVYKGSDEILLSKLVLDPAHSILKQSFDSRLRLDTRRGQNNADGFGIGFYTDPKLGAAPCLFTSTTPAWNCSNLHRLASKTASRLVFAHVRATTEGSLSEDNCHPFCHGSLMWMHNGGLGGWKQIKRRLGERLADKWYLNVGGGTDSEWAFALFLDTLERMGHDPSSQPEDGFGPTVLRNAMLKTIAQINELIDNIPESVVHAENVDTRSLLNFSVSDGHSIICTRYIGSWSDEAASLYYSSGTLWETRAPTPDSRDYQMERSDKGADVVLVASEPLSFERENWVNVPTNSILTIHNQTVMVHPIMDKYYDRNPQHRRSAAFVRTKGLSANEKGTSRSGTPFGLPAGTPPVSSLAHFPDHAEPHKQRFRGPTIPTIPSIPSSLSGSRTPDGFSSSSTLPRSRTPLSHAETIAPESSSSSLQAPPMDVRALTAPPVIRAASQQPPAQGNIKKKRASLTAVEAVHGGLVQYFDTSPSTPEPVRTEFGNPDKIARMFPELALQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P8T4</accession>
    <name>A0AAN6P8T4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_21230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854756">
        <property type="protein sequence ID" value="KAK4031577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P8T4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="281"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4031577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="313" mass="35032" checksum="3996B13CDC51A0FC" modified="2024-10-02" version="1">MKAHHQKVLSSGPTLDWDGGSIDIFRTFYRVRALDDMWRGVTIAFGLGSLGIDRVSWWQSLSFLTDLGPLYAVLLMESCRPANRWTPAYFATTATFLAQLLGIGAVAPLFYFLSFVFGPQAKDLADRQIQQLDPSQFALLLPLILALHTFEILGAYLSPDLVSRHYWIWAWQMSPLWIGVANFISARAVGSWLRNSRLASPAFIFQVLCAISAGVWISTLLLSPYSVSEIFLPTLARQTDDHLHTRRAFQVDEVSAFTACFLWLAYLLLDMHSAGLVGLNGFWPIAVLPIVLTFLGPGVTVALVWSWREAMFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P8U6</accession>
    <name>A0AAN6P8U6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L36</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_20060</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854563">
        <property type="protein sequence ID" value="KAK4032932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P8U6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1760:FF:000003">
        <property type="entry name" value="60S ribosomal protein L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1760">
        <property type="entry name" value="60S ribosomal protein L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000509">
        <property type="entry name" value="Ribosomal_eL36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038097">
        <property type="entry name" value="Ribosomal_eL36_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10114">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01158">
        <property type="entry name" value="Ribosomal_L36e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01190">
        <property type="entry name" value="RIBOSOMAL_L36E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="19"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4032932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="108" mass="12074" checksum="D2C1B1C11476B4D8" modified="2024-10-02" version="1">MAASKKETPRTGLATGLNKGHKTTARVSKPRVSRTKGHLSKRTAFVRELVKEVAGLAPYERRIIELLRNSKDKRARKLAKKKLGTFGRAKAKVEDMNRVIAESRRAGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P906</accession>
    <name>A0AAN6P906_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alginate lyase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_40593</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854561">
        <property type="protein sequence ID" value="KAK4032975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P906"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014895">
        <property type="entry name" value="Alginate_lyase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08787">
        <property type="entry name" value="Alginate_lyase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042974571" evidence="1">
        <location>
            <begin position="19"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Alginate lyase 2" evidence="2">
        <location>
            <begin position="30"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4032975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="255" mass="27122" checksum="71DA1E520E1EEF3D" modified="2024-10-02" version="1">MQLPVLVALPFFLGHVAAALNPSCRPGGNFDLSKWALETPIDNGNGQPLVISAASLSGGNDGCKNGWQDKGSDHQWFFTESTDGSMVMKAPGYSMDHPCIKWSGSSHYRTEFRETSPTSWSPSAATNRLHVKLVGIRGSNVCIGQVFQAGGSANKPFAELYYQDGTVVMGVATCPGGANDGCGQDMQKLGTVALGTAFTYDIRFEGNVLKAGVNGQVNTLRTHFTTPGAMFKVGNYNQGTDDASIHILELTTQHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P909</accession>
    <name>A0AAN6P909_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_19143</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854500">
        <property type="protein sequence ID" value="KAK4033978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P909"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4033978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="104" mass="11696" checksum="F003999073723315" modified="2024-10-02" version="1" fragment="single">VRDYGALMPTMVYNCAYMPSICKNVEKYLGPFPVSGQEKVFHTDRDPNTGIRSRPAARRHAVCPSSWNNNGRCPEQDQPAWTGYTTQEGRLHKVGPMPGLLSRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P977</accession>
    <name>A0AAN6P977_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Rad17 cell cycle checkpoint protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_49514</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the rad17/RAD24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854499">
        <property type="protein sequence ID" value="KAK4034015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P977"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004582">
        <property type="entry name" value="Checkpoint_prot_Rad17_Rad24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057927">
        <property type="entry name" value="RAD24-like_helical"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12172">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12172:SF0">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03215">
        <property type="entry name" value="Rad17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25812">
        <property type="entry name" value="RAD24_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Checkpoint protein RAD24-like helical bundle" evidence="9">
        <location>
            <begin position="567"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="186"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="350"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="733"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="766"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="858"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="43"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="97"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="191"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="206"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="230"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="359"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="778"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="802"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="865"/>
            <end position="878"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4034015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="943" mass="99802" checksum="2353EE44422189C9" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P9D2</accession>
    <name>A0AAN6P9D2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="18">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">C8A01DRAFT_20241</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="function">
        <text evidence="17">This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Transports the calcium to the vacuole and participates in the control of the cytosolic free calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="18">Membrane</location>
            <topology evidence="18">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15 18">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="18"/>
    <dbReference type="EMBL" id="MU854581">
        <property type="protein sequence ID" value="KAK4032723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P9D2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02081">
        <property type="entry name" value="P-type_ATPase_Ca_PMCA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000039">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000028">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000031">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000018">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006408">
        <property type="entry name" value="P-type_ATPase_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01517">
        <property type="entry name" value="ATPase-IIB_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093:SF369">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 18" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 18" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13 18" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 18" id="KW-0813">Transport</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="404"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="445"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="979"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1015"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1052"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="22">
        <location>
            <begin position="159"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="20">
        <location>
            <begin position="262"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase C-terminal" evidence="21">
        <location>
            <begin position="923"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="121"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1137"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1204"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00038148"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048694"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00059328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU361146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF00690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KAK4032723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1231" mass="132221" checksum="8C31D819E70B3787" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P9E3</accession>
    <name>A0AAN6P9E3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_40827</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854580">
        <property type="protein sequence ID" value="KAK4032738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P9E3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <begin position="163"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4032738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="361" mass="37860" checksum="B9288C5DC5398A5D" modified="2024-10-02" version="1">MRLLPLFIPLVSAKTLGSWTISAFSRQCNPQDTSCTYTLTLNTTPRDSPTATDTDTDTDLHTCTFTVTNTPSAGDTHDVALARASKTDFSSIPCGGTSRTTGQQQRYALNGGWSDGDVKGGGFLTLVPTDLVRKECAFFGYGEGELAGGRVVGEREGEVYPVGGFGSSSSLGSRSDSDSDADGIGSGLGAGGVGVGGESNGERSVRVGEGMRGVRMVDMKTVLEGGLANMDGGKIERVGKRGAAGDRSQWQIKGLTRYPDIGANTTKWQFTVVDGAGKETHCSLAAPTSDPVGSFYGIPCGTDADANFKASWGYNDDADSAVMTVCFTPNGTDAWFGFEQVSHNQWLGDSKKEPVYYTGCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P9J2</accession>
    <name>A0AAN6P9J2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">UBX domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_18928</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854488">
        <property type="protein sequence ID" value="KAK4034233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P9J2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061025">
        <property type="term" value="P:membrane fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031468">
        <property type="term" value="P:nuclear membrane reassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.210:FF:000002">
        <property type="entry name" value="UBX domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.210">
        <property type="entry name" value="SEP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036241">
        <property type="entry name" value="NSFL1C_SEP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012989">
        <property type="entry name" value="SEP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23333:SF20">
        <property type="entry name" value="NSFL1 COFACTOR P47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23333">
        <property type="entry name" value="UBX DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08059">
        <property type="entry name" value="SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00553">
        <property type="entry name" value="SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102848">
        <property type="entry name" value="NSFL1 (p97 ATPase) cofactor p47, SEP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51399">
        <property type="entry name" value="SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEP" evidence="3">
        <location>
            <begin position="215"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="UBX" evidence="2">
        <location>
            <begin position="331"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="297"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4034233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="412" mass="44562" checksum="5CA1B031DB7EA362" modified="2024-10-02" version="1">MADHDTLISNFCELTGASTEQATEYLSASNWDIDSAVTSYYTDMDEGEQGPASTAAAAPEPEYTGPRTLDGRPAPEYAAASSSSAAKKPQKRTGLATLSSLGGGHNHDDSEDDEDYDDDEEDDRRGPRDLFAGGEKSGLAVQDPAQRSSDPRRLINDIVAKARTSSRQPDEESAGPSRARFRGSGQTLGGDGVESRVIPDPRGSAIPTATSEGPAQERVLHIWTDGFSIDDGELRRFDDPQNRADLQMIREGRAPIHLMNVRLDQRVDVKLQQHNEDYRPLPKVYRPFGGEGRRLGSPVPGEVAAPEPAAATATAAAASTSSQGPSTGVDESQPTLMLRIQLPDGTRLPARFNTSHTVGDVYDFIQRSSPSINSREWVLSTTFPNKEHEEKGLVLGEMAEFKRGGTAVVKWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PA09</accession>
    <name>A0AAN6PA09_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Beta-lactamase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_40532</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854558">
        <property type="protein sequence ID" value="KAK4033008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PA09"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07722">
        <property type="entry name" value="LACTB2-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000328">
        <property type="entry name" value="Lactamase beta 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.15.10:FF:000041">
        <property type="entry name" value="Metallo-beta-lactamase domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047921">
        <property type="entry name" value="LACTB2-like_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041516">
        <property type="entry name" value="LACTB2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050662">
        <property type="entry name" value="Sec-metab_biosynth-thioest"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23131">
        <property type="entry name" value="ENDORIBONUCLEASE LACTB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23131:SF0">
        <property type="entry name" value="ENDORIBONUCLEASE LACTB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17778">
        <property type="entry name" value="WHD_BLACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="6">
        <location>
            <begin position="55"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4033008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="334" mass="36226" checksum="D844D9DE69E5BBF6" modified="2024-10-02" version="1">MRLPPAGPFLKKPLLQPSRLKMTTPQLPPLPEVERLSPGCIRILAGNPGKFTLQGTNTYLVGTSSARILIDTGEGRPSWIAALQRVLRDERAAVAYTLITHRHHDHTGGIPDLLRAWPGMRVYKHQPEEGQLELADGMQFRVEGASLRAVHTPGHTADHMSLHFLEENALFTGDNVLGHGTSVFEDLATYVASLERMRHLFVSGDDDGTTTTITTSNTGRAYPGHGAVVEDGPGKIAEYIRHRGQREEQVVQTLRSGGAEVEAAAAAGVDGNGKGDAWTVMELVRSIYRDVPESLHPAAAGGVVQILQKLQREGRAVAVDDGERWRLASGRSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PA84</accession>
    <name>A0AAN6PA84_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_40435</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854551">
        <property type="protein sequence ID" value="KAK4033113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PA84"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF81">
        <property type="entry name" value="PROTEIN ABHD13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="140"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4033113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="395" mass="43732" checksum="00DA7E78235C28E6" modified="2024-10-02" version="1">MANTASVLVPSLVVGVPLAGYIFFLGLSAVPYLQRNFLYAHKINTLWWGDINKPEQWGFAKNQVTPFHLTTADNQTLYAWHILPLPLYTQHEAKLSSQPSGLSPDITTTENFRLLRDDPSARLIISFHGNAAQLTQGYRPAHYHSLTSLHSPYHLLTLDYRGFGLSTGTPTEQGLIRDAEAAVRWAVHTAGVPPSRIVLVGHSLGTAVATAVTEHFALGRGEWDFAGVVLVAGFSSLPDMLSGYAIAGWVPVLRPLTWWPWLLRKVMGRVVDRWESAGRWREVVKGVKGRGGRLRLSLVHARNDWDIPCHEDDKLFKAAVEGLVGGGMDGEEFEAEKKKRTVVRGKDSFVATWREGRVVVRQELFPHGGHNAVLTYTPVLAAVMRSFGLDDESTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PAL4</accession>
    <name>A0AAN6PAL4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Acetyltransferase component of pyruvate dehydrogenase complex</fullName>
            <ecNumber evidence="8">2.3.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">C8A01DRAFT_48923</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + acetyl-CoA = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:17017"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:10478"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="2.3.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
        <text evidence="8">Binds 1 lipoyl cofactor covalently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Eukaryotic pyruvate dehydrogenase (PDH) complexes are organized as a core consisting of the oligomeric dihydrolipoamide acetyl-transferase (E2), around which are arranged multiple copies of pyruvate dehydrogenase (E1), dihydrolipoamide dehydrogenase (E3) and protein X (E3BP) bound by non-covalent bonds. The Chaetomium thermophilum PDH complex contains 60 E2 units, 12 E3BP units, about 20 E1 units, and 12 or more E3 units. The units are organized in 1 E2 60-mer, 4 E3BP trimers, about 20 E1 tetramers, and a maximum of 12 E3 dimers. The E3BP trimers are bound inside the icosahedral core with tetrahedral symmetry.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.12" evidence="8"/>
    <dbReference type="EMBL" id="MU854466">
        <property type="protein sequence ID" value="KAK4034780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PAL4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045254">
        <property type="term" value="C:pyruvate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004742">
        <property type="term" value="F:dihydrolipoyllysine-residue acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000010">
        <property type="entry name" value="Acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000003">
        <property type="entry name" value="Acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="entry name" value="E3-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045257">
        <property type="entry name" value="E2/Pdx1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006257">
        <property type="entry name" value="LAT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01349">
        <property type="entry name" value="PDHac_trf_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151">
        <property type="entry name" value="DIHYDROLIPOAMIDE ACETYL/SUCCINYL-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151:SF90">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3 8" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="6" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="10">
        <location>
            <begin position="34"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="11">
        <location>
            <begin position="176"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="127"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00061729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK4034780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="459" mass="48294" checksum="CABB7D32BDBE8433" modified="2024-10-02" version="1">MLVPAIRRQALQHARLARVAVPSLTRWYASYPPHTVVKMPALSPTMTAGNIGAWQKKPGDSIAPGEVLVEIETDKAQMDFEFQEEGVLAKILKESGEKDVAVGNPIAVLVEEGTDVSAFEGFSLKDAGGEAAPAAPAKEEQPKSESAPTPAPTPAPEAEETGFGGKLETALDREPNISAAAKRIAIEKGVSLKGLKGTGAGGKITEEDVKKASSAPAAGAAAVSGALYEDIPISGMRKTIASRLKESVAENPHYFVTSSLSVSKLLKLRQALNSTSEGKYKLSVNDFLIKAMAVACKKVPAVNSSWRDGVIRQFNTVDVSVAVSTPSGLITPIVKGVEGKGLEGISSAVKALAKKARDNKLKPEEYQGGTISISNMGMNPAVERFTAVINPPQAAILAVGSTKKVAVPAENEDGTTSVEWDDQIVVTASFDHKVVDGAVGAEWMRELKKAIENPLELLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PB36</accession>
    <name>A0AAN6PB36_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_48684</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854456">
        <property type="protein sequence ID" value="KAK4035073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PB36"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26200">
        <property type="entry name" value="Rcat_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4035073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="276" mass="31489" checksum="D79770672B763F4D" modified="2024-10-02" version="1">MSDEKLQCAVCLDGFEEGAHPVCRNRHAWCRACVLASVETAARSITDASCMPPRCCGDLVLPADGIFDWHQHPEEAARRFRAMHEVRGVYVDRAVIRAARHARGRNIFQFCPRCKRLVMRSGGCNHMVCLCGHEFCIICAKHWPPSHEDSEGRQPLCHPFYGCEDQHVLQIPPEVQARLDEEENQPPAAFADETAKGILCNHESDMLYTLRLRRDLEEEERNRARCDVCGKTFRAFLLQCIACRTLLCLGCRDLLWYEQVDDVADAFKELDIGKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PB67</accession>
    <name>A0AAN6PB67_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_40413</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854550">
        <property type="protein sequence ID" value="KAK4033126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PB67"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042926183" evidence="3">
        <location>
            <begin position="23"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="194"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="141"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="262"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4033126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="419" mass="43383" checksum="6D2C61EF0A13818A" modified="2024-10-02" version="1">MPRRRLALWAASIAAVHTAASAVPMNELFMRQSSCAPNFDRCKNPDFPDYFCCKPGNTCIALAGNTTVLCCPEGSDCLRIQPVPCNLSLQDGEKNPDAVVKTTALGGTLGRCGTQCCPFGYSCDKEQCVMDQNQNAVPIQTNTAKPGPTTTAGANPSLTSDASPTPDTTSPADDPNATTGASDGASTSGSSTPVAAIAGGVTAAAVVLIGAAVLAFIFLRKKKKKEPSQAGSPPKFSRSTSSFGNLISNPIIADNSFLSDFARAPGPGPGQRQPPEDPDSVTGAVLDSSVNSPEAGPMPAVPLAAALGPDPQGGGAGYGGYGGLEPSQFVDMPYVDHDNGLMPQTPRQHREPSSVSINVFADPNITPDRTPESNADRRYTNMTTFTQMLDNADLGGMARGESYLPYGQNGGQVPPMPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PBE4</accession>
    <name>A0AAN6PBE4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chaperone protein DnaK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_19386</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854514">
        <property type="protein sequence ID" value="KAK4033713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PBE4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10170">
        <property type="entry name" value="ASKHA_NBD_HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF82">
        <property type="entry name" value="FAMILY CHAPERONE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G08575)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4033713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="577" mass="64540" checksum="CB35822A5F574D78" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PCK1</accession>
    <name>A0AAN6PCK1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Chromatin modification-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">C8A01DRAFT_18887</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Component of an histone acetyltransferase complex.</text>
    </comment>
    <comment type="function">
        <text evidence="12">Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Involved in cell cycle progression and meiosis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="16">The PHD-type zinc finger mediates the binding to H3K4me3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the ING family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854486">
        <property type="protein sequence ID" value="KAK4034283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PCK1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16858">
        <property type="entry name" value="ING_ING3_Yng2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15505">
        <property type="entry name" value="PHD_ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028651">
        <property type="entry name" value="ING_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024610">
        <property type="entry name" value="ING_N_histone-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333:SF100">
        <property type="entry name" value="CHROMATIN MODIFICATION-RELATED PROTEIN YNG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12998">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01408">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7 16" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0469">Meiosis</keyword>
    <keyword evidence="3 14 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14 16" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 15 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="18">
        <location>
            <begin position="447"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="189"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="189"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="237"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="259"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="335"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="359"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="434"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="450"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="452"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="463"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="468"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="474"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="477"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="490"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="493"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="13">
        <location>
            <position position="449"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="13">
        <location>
            <position position="460"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="13">
        <location>
            <position position="464"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="13">
        <location>
            <position position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU361213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAK4034283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="502" mass="53443" checksum="1FB4A13CA8EFF1DC" modified="2024-10-02" version="1">MPRDDLSIDFVRKMPPVESLDAALILDEWFNRTQNFPDELRFLQEEVADKDRQYDKLVREIDERDGRIQKWIKAHGSHHPNPKEEEYRATIRKNFALAEQLSNEKIALTQKLHQNMDKHIRQLDMQLKMLFDRGEPGFTDPDELPSLLRASAANTTNGAAGPRGANVANPAASALNNMATGAQARAANAQVRNAQVRNAQAQQHGSASAPATPAASMIMNRQARESSAGPATKRMPRSNSGLGTLPATSSGLARHSSLGPGTPKGQTTPGVQRAGSAGPRATSKGALAGGVRKAGTPSSTAGRKKGTPGAGTHKSGLSRVKRAAKNSPSSAAESELSDADSASDDESDTRTGGRGTPAASFSRSASNQTTQPPSAGGGGGGRGRDSSNHNHPHHRTPPGATNYPHPERSGTTRPSPHPRSGGGEAASAGTNNDDMMDVDDDEAGDDRKYCSCQNVSFGNMVACDNDECPYEWFHWGCVGLKSEPNGTWYCPECSEKLRRKAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PCK9</accession>
    <name>A0AAN6PCK9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_39640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854504">
        <property type="protein sequence ID" value="KAK4033906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PCK9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="463"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="401"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="537"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="566"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="577"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="591"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4033906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="807" mass="90220" checksum="ECDAC273C9FFAA3A" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PDT4</accession>
    <name>A0AAN6PDT4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase A4 family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_47397</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854411">
        <property type="protein sequence ID" value="KAK4039063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PDT4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070007">
        <property type="term" value="F:glutamic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13426">
        <property type="entry name" value="Peptidase_G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.700">
        <property type="entry name" value="Peptidase G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000250">
        <property type="entry name" value="Peptidase_G1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038656">
        <property type="entry name" value="Peptidase_G1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37536:SF1">
        <property type="entry name" value="ASPERGILLOPEPSIN, PUTAITVE (AFU_ORTHOLOGUE AFUA_7G01200)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37536">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02970)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01828">
        <property type="entry name" value="Peptidase_A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00977">
        <property type="entry name" value="SCYTLDPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042976106" evidence="2">
        <location>
            <begin position="18"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600250-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4039063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="273" mass="28954" checksum="1DD894ABBF04353B" modified="2024-10-02" version="1">MNLTAILHAVLLGLTVALSHPREPSNELSLPAARRSRLTDRLNTLFTHNSSDTPPTVTYNANWAGAVLTGAGYRSATGTIQVPAIRLPPGADSNVLHAVSAWVGIDGEYACPNAILQVGVDMYMNHSVPAYWAWLEWFPNRSTYLTDFVIRPGDSITMTVMATSRSSATFSITNHATGQKDSASLADQAPLLCGFNAEWIVEDFWGSDGVPLVDFGSVAFTGALFETDTGISGGVEGAKMDGVKEKAGGPAVIECEKLGGSELTCEYKKGASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PEQ6</accession>
    <name>A0AAN6PEQ6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial carrier domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">C8A01DRAFT_16739</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854405">
        <property type="protein sequence ID" value="KAK4039282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PEQ6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000064">
        <property type="term" value="F:L-ornithine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990575">
        <property type="term" value="P:mitochondrial L-ornithine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000109">
        <property type="entry name" value="Ornithine carrier protein AmcA/Ort1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF31">
        <property type="entry name" value="MITOCHONDRIAL ORNITHINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="28"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="136"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="254"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK4039282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="347" mass="37770" checksum="AE8205F53B600631" modified="2024-10-02" version="1">MEPATTQEGGLKPFPGTVSAPKPRTAVMEAIEDILYGSIAGVVGKYIEYPFDTVKVRLQSQPDHLPLQYRGPLDCFRQSVRADGLLGLYRGISAPLVGAALENSSLFFWERLGRAAIYASGVYSSSSSRGEAAAALPLSALWLTGAFSGAMTSFVLTPVELVKCKIQVPDTAMTGEGGGGAAKALRPIPVIKDIWRHQGLRGFWHGQLGTLIRESGGCAAWFGSKETVTKLMREWNERRRRAVRREEKEEDDALPLWQQAVAGASAGMMYNFLFFPADTVKSRMQTSPIGEGAAQQRSFAGECAALWKQAGLKGFYRGCGITVLRSVPSSAFIFIVYDGLKKYFPLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PET5</accession>
    <name>A0AAN6PET5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription factor BYE1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_46948</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Negative regulator of transcription elongation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BYE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
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    <feature type="region of interest" description="Disordered" evidence="7">
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    <feature type="region of interest" description="Disordered" evidence="7">
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
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            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="782"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
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    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
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            <end position="57"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
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            <end position="164"/>
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    </feature>
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            <begin position="165"/>
            <end position="175"/>
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    </feature>
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        <location>
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            <end position="210"/>
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    </feature>
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        <location>
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        <source>
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    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51321"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK4039618.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="906" mass="98850" checksum="1380F13D757BA6F4" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PF67</accession>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">C8A01DRAFT_37916</name>
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        <name type="scientific">Parachaetomium inaequale</name>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DNA ENDONUCLEASE ACTIVATOR CTP1 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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    <feature type="region of interest" description="Disordered" evidence="2">
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        </location>
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        </location>
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            <end position="63"/>
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        <location>
            <begin position="704"/>
            <end position="719"/>
        </location>
    </feature>
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        <source>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PFB1</accession>
    <name>A0AAN6PFB1_9PEZI</name>
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        <recommendedName>
            <fullName evidence="13">Small ribosomal subunit protein uS10m</fullName>
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            <fullName evidence="15">Mitochondrial ribosomal small subunit protein 10</fullName>
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        <alternativeName>
            <fullName evidence="12">Tryptophanyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
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        </lineage>
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    <reference evidence="19" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="4"/>
    <dbReference type="EMBL" id="MU854388">
        <property type="protein sequence ID" value="KAK4039924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PFB1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070183">
        <property type="term" value="P:mitochondrial tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00806">
        <property type="entry name" value="TrpRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.600:FF:000003">
        <property type="entry name" value="30S ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.240.10:FF:000002">
        <property type="entry name" value="Tryptophan--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="entry name" value="Ribosomal protein S10 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00508">
        <property type="entry name" value="Ribosomal_uS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014810">
        <property type="entry name" value="Fcf2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001848">
        <property type="entry name" value="Ribosomal_uS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_uS10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_uS10_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050203">
        <property type="entry name" value="Trp-tRNA_synthetase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43766">
        <property type="entry name" value="TRYPTOPHAN--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43766:SF1">
        <property type="entry name" value="TRYPTOPHAN--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08698">
        <property type="entry name" value="Fcf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="Ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="9" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS10" evidence="17">
        <location>
            <begin position="281"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="776"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="786"/>
            <end position="800"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00035261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00042916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00078476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAK4039924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="826" mass="91797" checksum="B09C2B1D243AC5A5" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PFM8</accession>
    <name>A0AAN6PFM8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Canalicular multispecific organic anion transporter 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">C8A01DRAFT_46604</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">ABC-type transporter; part of the gene cluster that mediates the biosynthesis of the phomopsins, a group of hexapeptide mycotoxins which infects lupins and causes lupinosis disease in livestock.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854386">
        <property type="protein sequence ID" value="KAK4040031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18579">
        <property type="entry name" value="ABC_6TM_ABCC_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000055">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000066">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001854">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044746">
        <property type="entry name" value="ABCC_6TM_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056227">
        <property type="entry name" value="TMD0_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF345">
        <property type="entry name" value="ABC MULTIDRUG TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24357">
        <property type="entry name" value="TMD0_ABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="128"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="310"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="411"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="490"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="519"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="878"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="920"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="958"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="999"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1081"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="279"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="598"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="878"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="1174"/>
            <end position="1462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="571"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1234"/>
            <end position="1268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="1234"/>
            <end position="1246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00059074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK4040031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1469" mass="160022" checksum="248757045B85B64F" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PFQ7</accession>
    <name>A0AAN6PFQ7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_15996</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854384">
        <property type="protein sequence ID" value="KAK4040098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="3">
        <location>
            <begin position="346"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="262"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="880"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1038"/>
            <end position="1063"/>
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            <end position="1215"/>
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    </feature>
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        <location>
            <begin position="1338"/>
            <end position="1376"/>
        </location>
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            <end position="317"/>
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    </feature>
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        <location>
            <begin position="262"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="914"/>
            <end position="929"/>
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            <begin position="1039"/>
            <end position="1048"/>
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        <location>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
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            <begin position="1367"/>
            <end position="1376"/>
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        </source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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            <dbReference type="EMBL" id="KAK4040098.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1458" mass="162860" checksum="927C29CBFB90034C" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAN6PFZ2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_36613</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854401">
        <property type="protein sequence ID" value="KAK4039403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PFZ2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050791">
        <property type="entry name" value="Aldo-Keto_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625">
        <property type="entry name" value="AFLATOXIN B1 ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625:SF40">
        <property type="entry name" value="ALDO-KETO REDUCTASE YAKC [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="21"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4039403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="347" mass="38071" checksum="5596EF3891EA8235" modified="2024-10-02" version="1">MAPPAKLPTRKLGEDGPEITAIGFGLMGLSTAYGSVGSDEDRLKVLDRAWELGCTNWDSANMYGDSEDLLGKWFARHPERRADIFLATKFGLWPGVRDDGSRGLVVNSSPEYCREQCEKSLRRLGVDCIDLYYIHRVDGKTPIEKTMAELVKLKEEGKIKHIGISACSSATLRRACAVAPVAAYQVEYSPWALDIEGPESGHALQTCRALGITVLAYAPLGRGIMTGQIASPDDFEPGDLRRLYPRFSRENFPKNLELVARFRDMAARKGCTPGQLTMAWLLAQGLDVVPIPGTKNVRYLEENVAAVHVSVSAEEEGVIRGWLEDVGIAGIRVPPGLLDEFNDTPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PGD9</accession>
    <name>A0AAN6PGD9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Dihydrodipicolinate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_36411</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DapA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854396">
        <property type="protein sequence ID" value="KAK4039628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PGD9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00408">
        <property type="entry name" value="DHDPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128:SF24">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHETASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_3G11920)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="2">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4039628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="331" mass="34926" checksum="97085F0676D0B273" modified="2024-10-02" version="1">MPDPPPSPSGGHSPLPKGIWAPTQVFFHPTAPFDVDLPTTAQHAVRLARAGVVGIVTNGSNGEAAHLSPLERSSVTRATRTALDEAGFCHVPVMSGASDQSVRGTLKLIEDAKEAGAVAVLVLSPSFFRWAVADPSVVEGFFLAVADQSVLPLVVYNYPGAVAGVDLNSDLLGRLSQHKNVVGVKFTCGNVGKLARVAALSVTKGKGGEFRCYSGVADAITPSLAVGGHGGIVGAANVFPRACVEVYRLFDQGRWEDARAAQQRLAEADWALTKRAIPGFKSVLQKYHGYGGIPRLPVLPLSGEEEEKLFGEVEEMMAAEARLEDVGRVSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PGR1</accession>
    <name>A0AAN6PGR1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription factor CBF/NF-Y/archaeal histone domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_35661</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
            <location evidence="2">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the CENP-W/WIP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854379">
        <property type="protein sequence ID" value="KAK4040332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PGR1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13732">
        <property type="entry name" value="HFD_CENP-W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000075">
        <property type="entry name" value="WGS project CABT00000000 data, contig 2.56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052484">
        <property type="entry name" value="CENP-W/WIP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34832">
        <property type="entry name" value="CENTROMERE PROTEIN W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34832:SF1">
        <property type="entry name" value="CENTROMERE PROTEIN W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0137">Centromere</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="8">
        <location>
            <begin position="8"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4040332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="77" mass="8493" checksum="11C79037104DFE26" modified="2024-10-02" version="1">MAGQKLYPRATVKKIVKAHSNCNVSKNADVMMFLDYMLFMQTLVKEAAIEAKQGGERGITARSVKKVTADSLAKFRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PGR2</accession>
    <name>A0AAN6PGR2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Clustered mitochondria protein homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Protein TIF31 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">CLU1</name>
        <name evidence="3" type="synonym">TIF31</name>
        <name evidence="6" type="ORF">C8A01DRAFT_36328</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">May associate with the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CLU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854394">
        <property type="protein sequence ID" value="KAK4039705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd15466">
        <property type="entry name" value="CLU-central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000293">
        <property type="entry name" value="Clustered mitochondria protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2280.10:FF:000002">
        <property type="entry name" value="Clustered mitochondria protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2280.10">
        <property type="entry name" value="Hypothetical protein (hspc210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03013">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033646">
        <property type="entry name" value="CLU-central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025697">
        <property type="entry name" value="CLU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028275">
        <property type="entry name" value="CLU_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027523">
        <property type="entry name" value="CLU_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023231">
        <property type="entry name" value="GSKIP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12601:SF6">
        <property type="entry name" value="CLUSTERED MITOCHONDRIA PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12601">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT EIF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13236">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15044">
        <property type="entry name" value="CLU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12807">
        <property type="entry name" value="eIF3_p135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103107">
        <property type="entry name" value="Hypothetical protein c14orf129, hspc210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51823">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Clu" evidence="5">
        <location>
            <begin position="328"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="613"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="890"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1248"/>
            <end position="1284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="613"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="890"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="921"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1248"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1262"/>
            <end position="1276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4039705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1284" mass="141368" checksum="B4AEA550F6D257CC" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PGT2</accession>
    <name>A0AAN6PGT2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pre-mRNA-splicing factor SLU7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">C8A01DRAFT_15438</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the SLU7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854371">
        <property type="protein sequence ID" value="KAK4040698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PGT2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030628">
        <property type="term" value="F:pre-mRNA 3'-splice site binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021715">
        <property type="entry name" value="Slu7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039974">
        <property type="entry name" value="Splicing_factor_SLU7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12942:SF2">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SLU7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12942">
        <property type="entry name" value="STEP II SPLICING FACTOR SLU7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11708">
        <property type="entry name" value="Slu7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="10">
        <location>
            <begin position="93"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="401"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="404"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK4040698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="420" mass="46748" checksum="651B3A695A8B1E6F" modified="2024-10-02" version="1">MPPPPSRRPETASAAAAAASADSASGAGAARKEDNIYIPSYISKQPFYVSGLDDHDDSLQHQRRTAHDEEHFTFERGGKKAGAARTKWVKGACENCGAMGHKKKNCLERPRKVGAKFTGKDIQADRTVRDVKLGYEAKRDVWAAYDPKQYQEVVDEYNLVEEARRALQGQNGDKKEGEDVYESGFKYAEESELGKDKTVKQSMRIREDTAKYLLNLDSDSAKYNPKKRALVDGGAIGDKSSQLFAEESFLRASGEAAEFEKAQRYAWEAQERTGDTSLHLQANPTAGALMRKKEGDEREAKRRKRAEMLASQYGEQPTVPEALKAAIAESETFVEYDEAGLIKGAPRKAAKSKYPEDVFINNHTSVWGSWWSDFKWGYACCHSFVKNSYCTGDMGNQAIQQADSWDKQNGEDGEDARDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PHJ0</accession>
    <name>A0AAN6PHJ0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ethionine resistance-conferring protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_47376</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854410">
        <property type="protein sequence ID" value="KAK4039104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PHJ0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13132">
        <property type="entry name" value="MATE_eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045069">
        <property type="entry name" value="MATE_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11206">
        <property type="entry name" value="MULTIDRUG RESISTANCE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="310"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="373"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="401"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="447"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="527"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="599"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="626"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="47"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="48"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="110"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4039104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="665" mass="72110" checksum="720AC6470904DA9B" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PIT3</accession>
    <name>A0AAN6PIT3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Topoisomerase 1-associated factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_34254</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the timeless family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854353">
        <property type="protein sequence ID" value="KAK4041651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PIT3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031298">
        <property type="term" value="C:replication fork protection complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000076">
        <property type="term" value="P:DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043111">
        <property type="term" value="P:replication fork arrest"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044998">
        <property type="entry name" value="Timeless"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006906">
        <property type="entry name" value="Timeless_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22940:SF4">
        <property type="entry name" value="PROTEIN TIMELESS HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22940">
        <property type="entry name" value="TIMEOUT/TIMELESS-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04821">
        <property type="entry name" value="TIMELESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0236">DNA replication inhibitor</keyword>
    <keyword evidence="6" id="KW-0469">Meiosis</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Timeless N-terminal" evidence="9">
        <location>
            <begin position="37"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="325"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="558"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="795"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="896"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1023"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="325"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="558"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="575"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="915"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="989"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1023"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1095"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1106"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1122"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1143"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1158"/>
            <end position="1189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4041651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1231" mass="139101" checksum="0B539D8448062B4A" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PKW2</accession>
    <name>A0AAN6PKW2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_34992</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854366">
        <property type="protein sequence ID" value="KAK4040934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PKW2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042912430" evidence="1">
        <location>
            <begin position="17"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4040934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="74" mass="8185" checksum="EC4B6EE6AD6748A0" modified="2024-10-02" version="1">MQLRTALAFLAATVAAMQTEPQSKEVDFVVRRDSWKRASCAVELPNGRVQLSTAPIPTMFALDQPECVCKCHYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PL40</accession>
    <name>A0AAN6PL40_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein eS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">RPS1</name>
        <name evidence="9" type="ORF">C8A01DRAFT_44127</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="6">Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (25S, 5.8S and 5S).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the eukaryotic ribosomal protein eS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854334">
        <property type="protein sequence ID" value="KAK4042911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PL40"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03122">
        <property type="entry name" value="Ribosomal_eS1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001593">
        <property type="entry name" value="Ribosomal_eS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018281">
        <property type="entry name" value="Ribosomal_eS1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027500">
        <property type="entry name" value="Ribosomal_eS1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11830">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01015">
        <property type="entry name" value="Ribosomal_S3Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01397">
        <property type="entry name" value="Ribosomal_S3Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01191">
        <property type="entry name" value="RIBOSOMAL_S3AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 6 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="initiator methionine" description="Removed" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="modified residue" description="N-acetylalanine; partial" evidence="6">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4042911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="437" mass="49073" checksum="E8697365C70FA1C9" modified="2024-10-02" version="1">MAVGKNKRLSKGKKGLKKKAQDPFTRKDWYGIKTLVNRTTGLKNANDALKGRIFEVSLADLQKDEDHSFRKIKLRVDEVQGKNCLTNFHGLDFTSDKLRSLVRKWQTLIEANVTVMTTDHYLLRLFAIAFTKRRPNQIKKTTYAASSQIRAIRRKMTEIIQREASSCTLTQLTSKLIPEVIGREIEKATQGIYPLQNVHIRKVKLLKQPKFDLGTLMTLHGESSTDEQGQKVEREFREQVLENFVYPGDFGGTFRVVMVGPSGVGKSALLFRYCDHAFSDTKTATIGLDYKAGQERFGAVSKSYYRGAHGVILVYDISNRDSFLRLGKWFEEALERAPLGTVLCVVGTKLDKAEEEGGRQVTTAEGRTLAEGYGAAVFCEVSSKSGKNARTPFLALVSEMMQTPGLLGPANTRPYPKTTVVLDTRDPAWMKYMMCVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PLB5</accession>
    <name>A0AAN6PLB5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cleft lip and palate transmembrane protein 1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_44103</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CLPTM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854334">
        <property type="protein sequence ID" value="KAK4042887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PLB5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008429">
        <property type="entry name" value="CLPTM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21347">
        <property type="entry name" value="CLEFT LIP AND PALATE ASSOCIATED TRANSMEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21347:SF0">
        <property type="entry name" value="LIPID SCRAMBLASE CLPTM1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05602">
        <property type="entry name" value="CLPTM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="361"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="395"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="423"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="487"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="512"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="612"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4042887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="990" mass="110940" checksum="D4F738092B14BB7D" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PLE0</accession>
    <name>A0AAN6PLE0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Small acidic protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_44099</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SMAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854334">
        <property type="protein sequence ID" value="KAK4042882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PLE0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026714">
        <property type="entry name" value="SMAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028124">
        <property type="entry name" value="SMAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22175:SF0">
        <property type="entry name" value="SMALL ACIDIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22175">
        <property type="entry name" value="SMALL ACIDIC PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15477">
        <property type="entry name" value="SMAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small acidic protein-like" evidence="4">
        <location>
            <begin position="276"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="331"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="64"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="80"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="94"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="122"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="143"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="212"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="228"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="340"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF15477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4042882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="350" mass="37774" checksum="7823A4BEE4593F50" modified="2024-10-02" version="1">MGEKSKKKAREPKEEAATTTVAADASITDKKKKKSKKPKDDKAALAEADTSAVAETEEQPEIKKSKKEKKKDGKRKREAASAVPAETETAAEVETVKEAEEVEPPKKKKKAAKSDGDEKSEKKAKKNKAKKGKSTEEEESPAEEATVAEPTEIVSVKKKSKKGKKTKETADATDAQVDEPAEQHKADKKEKKKKRKDKDQDGDVEMADVSAEETKVEEKDEAAEGKKKKDKKAKKDKSKKRKTAETPEETPEEGAPATAPAPAPAAAPDADLAERWNVHGLGGGTSRQSKFMRLLGGKKHGAAATGVGEAKDGPRKRFDIGHVSNELEKQFEAGRQMKFGAGGQRKGLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PLE3</accession>
    <name>A0AAN6PLE3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sin3 binding protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_43849</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854330">
        <property type="protein sequence ID" value="KAK4043203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PLE3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000432">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by glucose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018818">
        <property type="entry name" value="Stb3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28164">
        <property type="entry name" value="PROTEIN STB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28164:SF1">
        <property type="entry name" value="PROTEIN STB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10330">
        <property type="entry name" value="Stb3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4043203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="369" mass="38898" checksum="6068CCA211E73B01" modified="2024-10-02" version="1">MATMASAVRDIAMTSGRDNLTAVAARSVPVATNPTDLPTPPNSISPSLPPHGLKAQLQRARLDSIDSDLDLLDGRREHGAGPGSPPYDSAGAITAAMLAKFHLPEILLNHGPLPIRHLMGYLTTSVPGFAGIAPAKARRLVVGALEGKGSGNEGGGLDGDVEFMKVGWGRWDAKRRGQPPRESLSRHASPGAHPNSIPIIKTPGWSTERSRLGANLGTSLGGFSAAFSHDDRFMDVDVDMDMDMMDHEADKMSLDGSGSASCSEAPDDDDMRRHNDDPEDATDDEDWAAVGAAALRASSYQANQQQSPFNNVHTLGGGGIRSFSTGMARPPQLSPPPRNFNFPASTLGAVAADAQEREAVEALLRLGSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PLF1</accession>
    <name>A0AAN6PLF1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_34900</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854364">
        <property type="protein sequence ID" value="KAK4041056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PLF1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10971">
        <property type="entry name" value="MRNA EXPORT FACTOR AND BUB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="24"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="112"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="264"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4041056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="353" mass="38025" checksum="6FACAE97309713AB" modified="2024-10-02" version="1">MAFGKGKPAAAAPKGLMEKDVVFPKGPEDTISALRWSPVANHLAAASWDGKVYIYDATNSTATDTIMGVAAITVGAPVLDCDFSKGGTLAAGAAADKKIHLMDLNSSKTMTLEAHTSPVRTVRFVQVPSANAPIIASGSWDKTVRYWDIRQPQPIGTLELPERVYAMDAAGPLLVTATADNHLHFVNLHGNPLELWKTVKSPLNYQTSSVSVYADGTRWAIGGIDGRAAAQVADANDKSLDNLQFKCHREQTPKKPNHADVYAVNAVAYSPTHKDVLATAGSDGTYSIWDVRGRNRLRSFPKVAGPVTAISFACDGMSLAYAVGYDWAKGYQHNSAGAERQIVLRRFEEELKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PM04</accession>
    <name>A0AAN6PM04_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Presequence protease, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Pitrilysin metalloproteinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">C8A01DRAFT_43619</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Degrades mitochondrial transit peptides after their cleavage in the intermembrane space or in the matrix, and presequence peptides; clearance of these peptides is required to keep the presequence processing machinery running. Preferentially cleaves the N-terminal side of paired basic amino acid residues. Also degrades other unstructured peptides. May function as an ATP-dependent peptidase as opposed to a metalloendopeptidase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer and homodimer; homodimerization is induced by binding of the substrate.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase M16 family. PreP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854327">
        <property type="protein sequence ID" value="KAK4043494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PM04"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000020">
        <property type="entry name" value="Mitochondrial presequence protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000009">
        <property type="entry name" value="Presequence protease, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000011">
        <property type="entry name" value="Presequence protease, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013578">
        <property type="entry name" value="Peptidase_M16C_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055130">
        <property type="entry name" value="PreP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43016">
        <property type="entry name" value="PRESEQUENCE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43016:SF13">
        <property type="entry name" value="PRESEQUENCE PROTEASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08367">
        <property type="entry name" value="M16C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22516">
        <property type="entry name" value="PreP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01264">
        <property type="entry name" value="M16C_associated"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M16C associated" evidence="15">
        <location>
            <begin position="487"/>
            <end position="745"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK4043494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1010" mass="112329" checksum="2BC43FE5D0CAAA6C" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PM73</accession>
    <name>A0AAN6PM73_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Quinate repressor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_32474</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the 2nd section; belongs to the type-I 3-dehydroquinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the shikimate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854328">
        <property type="protein sequence ID" value="KAK4043347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PM73"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003855">
        <property type="term" value="F:3-dehydroquinate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003866">
        <property type="term" value="F:3-phosphoshikimate 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01065">
        <property type="entry name" value="NAD_bind_Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001381">
        <property type="entry name" value="DHquinase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031322">
        <property type="entry name" value="Shikimate/glucono_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013708">
        <property type="entry name" value="Shikimate_DH-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006151">
        <property type="entry name" value="Shikm_DH/Glu-tRNA_Rdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21090">
        <property type="entry name" value="AROM/DEHYDROQUINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21090:SF17">
        <property type="entry name" value="QUINATE REPRESSOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01487">
        <property type="entry name" value="DHquinase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01488">
        <property type="entry name" value="Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08501">
        <property type="entry name" value="Shikimate_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01202">
        <property type="entry name" value="SKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Shikimate dehydrogenase substrate binding N-terminal" evidence="5">
        <location>
            <begin position="469"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase" evidence="4">
        <location>
            <begin position="603"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="660"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="669"/>
            <end position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4043347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="823" mass="91538" checksum="30FE12253997FFDE" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PMP8</accession>
    <name>A0AAN6PMP8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_12768</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854325">
        <property type="protein sequence ID" value="KAK4043652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PMP8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="195"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4043652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="312" mass="33638" checksum="F1BD7CBE44DBB58C" modified="2024-10-02" version="1">MVEESPASPSTKHVGPRRHRRTAAVPNIRLSELFESNLALPHGPAADTADIGIDTKDEVGETRSGAATHPLSAWEVEPSAILPQSSSLPTVLSASEPKRGCLRSSGGSAGEIEGMNSRERRLKLKVSRGAIAKARRQTGRTSGASLDSHCSTSGPLNHDRPKKAQLEKDTITRNTTTASPGAATRRRSKHPTNPPSAAAAAATTQKPTAPNENENDILALFTSSHSRVNGKALRRLKKRFPDLGARFFAELQLPQVQAQTTGGVSITGRVGSVQQEQQQQRRSAGRFFRGRVVVWMRRARQAVTRTRSTEKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PMQ8</accession>
    <name>A0AAN6PMQ8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_34288</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the proteasome complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase T1B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854353">
        <property type="protein sequence ID" value="KAK4041686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PMQ8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03758">
        <property type="entry name" value="proteasome_beta_type_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000008">
        <property type="entry name" value="Proteasome subunit beta type-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035206">
        <property type="entry name" value="Proteasome_beta2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF2">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4041686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="259" mass="28465" checksum="2B50A606150FCD84" modified="2024-10-02" version="1">MPCRHIQPQWAEAGWGPFVGLQQAWSVGGRCPCAQAEAPTLQITTTTTPFDTDNAKMEVLLGITGKDFTLIAASKAAMRGATILKAADDKTRQLNKHTLMAFSGEAGDTVQFAEYIQANAQLYSMRNETDLSPSALANFVRGELASSLRSRKPYNVNLLLGGVDPITHKPSLYWLDYLASLAPVPYAAHGYAQYYCLSLLDKHHQPDITLERGMELLKLCSDELKRRLPIDFKGMVVKAVTADGIKEMPFDDTEVVKGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PMW9</accession>
    <name>A0AAN6PMW9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_44166</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854335">
        <property type="protein sequence ID" value="KAK4042808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PMW9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042891032" evidence="1">
        <location>
            <begin position="17"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4042808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="87" mass="9378" checksum="3A993A8375E79E59" modified="2024-10-02" version="1">MKFSLAALLFVPLALAALPEQELTEDSVASGLVTSDVPKADGLNAAAYCPINYPYLCNGFCCPWNICCGLECCAPDTRYCSNGRCYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PMX4</accession>
    <name>A0AAN6PMX4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein HOL1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_14798</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854357">
        <property type="protein sequence ID" value="KAK4041425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PMX4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF181">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="314"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="359"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="399"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="430"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="463"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="494"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="55"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="257"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4041425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="530" mass="57970" checksum="81B43315A79E8729" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PNC7</accession>
    <name>A0AAN6PNC7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_45205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854353">
        <property type="protein sequence ID" value="KAK4041665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PNC7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790:SF4">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4041665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="361" mass="41091" checksum="FB1229D54CF9263B" modified="2024-10-02" version="1">MAQANLQSQSLLFQLPQEIRDHIYHQLFASTRFSFGRCVTGGIADFTVKPAPNGLALLRACRRAQLEIGNSWLRHVLFCFEDAKSMLDKLSALPTRTLSMMRRMRISGDTLMLTLPDDPDDTKVFYRLVAVLKLLPGLRLDQLTVLGTIWHQVNYDTLDGLITDGNGWKTLRYISCSSVMLGYPSRHQLPFMRPSWTEKPQSWRQPQPKHWQTVLEGRDGAASGPSVTIYRAKEPGSCGSILDPAKRVGYKQKPRKNPHSRPDVFPADPELMTGDEQHKEIMVVVKRGSGVDYGERKSSPFISSDIRRDFPGRTWAQTRAAYIDHRLGEDEEAERDPIREDVYSHVDEYAFQPPRIIIVDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PNW5</accession>
    <name>A0AAN6PNW5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_42696</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854318">
        <property type="protein sequence ID" value="KAK4044514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PNW5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070682">
        <property type="term" value="P:proteasome regulatory particle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038966">
        <property type="entry name" value="TMA17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40422">
        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40422:SF1">
        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="124"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="143"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4044514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="243" mass="26078" checksum="48B433D7F92E9CBD" modified="2024-10-02" version="1">MSSDALPINPARFAAALKDLPISTLHLKVLELRNSITHLDYSNEQLRPFADGTATALSPTTTSPSTQPQATQGTPDQDCVDAIRENEAVIERMQARIRLVRDEVESRGLSWTEFQSQAERDAEQQAQQEQKQQDGVEGGGVEGMVNGAVVNGGSSTGATTTAVNGERLQQQRQQHSAWTDGTFQTGVIRGGVVQMDDAAAGQGQGQQQGGSLTDEELRRRVEEQLRGLGGGEDEDEGEGGLHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PP31</accession>
    <name>A0AAN6PP31_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">pyridoxal 5'-phosphate synthase</fullName>
            <ecNumber evidence="4">1.4.3.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_43717</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxine 5'-phosphate: step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.5" evidence="4"/>
    <dbReference type="EMBL" id="MU854328">
        <property type="protein sequence ID" value="KAK4043408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PP31"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004733">
        <property type="term" value="F:pyridoxamine phosphate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000659">
        <property type="entry name" value="Pyridox_Oxase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019740">
        <property type="entry name" value="Pyridox_Oxase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019576">
        <property type="entry name" value="Pyridoxamine_oxidase_dimer_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00558">
        <property type="entry name" value="pdxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004231">
        <property type="entry name" value="PRK05679.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10851:SF0">
        <property type="entry name" value="PYRIDOXINE-5'-PHOSPHATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10851">
        <property type="entry name" value="PYRIDOXINE-5-PHOSPHATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10590">
        <property type="entry name" value="PNP_phzG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="PNPOx_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01064">
        <property type="entry name" value="PYRIDOX_OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0288">FMN</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyridoxamine 5'-phosphate oxidase N-terminal" evidence="8">
        <location>
            <begin position="73"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridoxine 5'-phosphate oxidase dimerisation C-terminal" evidence="9">
        <location>
            <begin position="223"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4043408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="268" mass="29782" checksum="DEE785A434DC00AA" modified="2024-10-02" version="1">MALYPTQEGSKLIFAPAGAHKSLEIPTGPGQAGQFLKAEHLGGLKRTDLDARDPVAQFHAWFDEASRPGSGVAHPETCTLSTAQLPSGRVSARMVYMKELDARGFVIYSNFGTSGKARDLFGAADGSSTGNPWASLVFWWEPLERQVRVEGRAERVPTAESQAYFDTRVRGSRIGAWSSRQSAVLEPDAGVEGDDGRTMLDNWVKETEARFEGADHIPVPEFWGGLRIVPERFEFWQGRQNRLHDRFVYDRVEGEDGGDKWTLERLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PPF4</accession>
    <name>A0AAN6PPF4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Concanavalin A-like lectin/glucanase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_11796</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854316">
        <property type="protein sequence ID" value="KAK4044793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PPF4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02181">
        <property type="entry name" value="GH16_fungal_Lam16A_glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF42">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_5G02280)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26113">
        <property type="entry name" value="GH16_XgeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="2">
        <location>
            <begin position="68"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4044793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="379" mass="40797" checksum="1645DE256839F11A" modified="2024-10-02" version="1">MKQSGPMVSSYEMGYSDSYGSRWNPGNWTRRIWLIVGTAVVVIVVAIVGAVVGVRATQNNGGGNSNYPDYSKLNYTLIDTYSGTTFFDKFDYFNTYDPAAGFVHYVHPSYAAQYNLTYATPSTALIRVDTTVGPDSEPDASTGRFSVRLESKAQYGPGLFLFDVKHTPYGCGTWPALWLTDPHNWPAHGEIDLMEAVNQATTGNLVALHTTSDCSMTDIRREMAGTAGQGDCHNATNSNTGCTVKGAPATYGPEFNAAGGGVVALEWRDEGIRVWVFSRGAEKGLTALPLVEAGGVAAAPDPSVWGPPLADFPATNCDMGSHFRNQSIIVNIDLCGYFTEAVWASSGCPSTCTDYVATNPSAFTDAYWEFGGFQVYKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PPG3</accession>
    <name>A0AAN6PPG3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid permease-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_11811</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854316">
        <property type="protein sequence ID" value="KAK4044808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PPG3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF512">
        <property type="entry name" value="SOBREMESA, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="298"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="381"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="423"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="507"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="534"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="570"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="596"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="18"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4044808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="642" mass="67577" checksum="191255B8D327985A" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PPK5</accession>
    <name>A0AAN6PPK5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS9m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">37S ribosomal protein S9, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_42446</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uS9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854316">
        <property type="protein sequence ID" value="KAK4044831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PPK5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000001">
        <property type="entry name" value="30S ribosomal protein S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000754">
        <property type="entry name" value="Ribosomal_uS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023035">
        <property type="entry name" value="Ribosomal_uS9_bac/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020574">
        <property type="entry name" value="Ribosomal_uS9_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001099">
        <property type="entry name" value="PRK00132.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
        <property type="entry name" value="RIBOSOMAL PROTEIN S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US9M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
        <property type="entry name" value="Ribosomal_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00360">
        <property type="entry name" value="RIBOSOMAL_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="308"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4044831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="330" mass="36691" checksum="95A6FCC0260471B2" modified="2024-10-02" version="1">MMASSSRPRLTSALRGVSRTLNGGQRQPLEQHFQSLQLNSSAVRGRRCLSTESTESNANGDRLSITAAKELEIKSLIKKLTPKYRLAQHARPVPISPSYFSRTPAFNDRYLVLEKLSRAYVNLPVIPAADTERIAWKTLSDLRQSFGEPVKATDYVKCLAIVKRLHQIHPELKPDAVKEALLDFQRDVQAFLNVATPIPIDKFGRALGVGKRKSSSARAFVVEGEGQVLINGKTLADYFGRVHDRESAVWALHATDRIDKYNVWARVEGGGTTGQAEALTLAIAKALLAHEPALKPALRRAGVVTRDPRRVERKKHGRVKARKGPTWVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PQ43</accession>
    <name>A0AAN6PQ43_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_32704</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854330">
        <property type="protein sequence ID" value="KAK4043214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PQ43"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="305"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="333"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4043214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="359" mass="37207" checksum="E32E45F9889107D2" modified="2024-10-02" version="1">MGRAREAAAEAAAAVADGAAATLSPADTTTGPSGRAESIAKLAALSPRRTARLPGPARFALAVVLSFALSSLGRSFVDHCSNNEVGSITREANSRTELAVLAAWKLFGLALGWFGDYDGFDLAALALLSHGPATFLISVFYGVRALTAGAYLAVEVVSASLPFVLLRRLSGAHSAAPGVPNRDIVADGTIQALTSLQSALVYSVVLFLAGRFVLPDSLVLYFEGIPTVQPAADAAFLGLGSPTTQLLSLLFGLAARTFIFTPLVTTPQQTAEDRENAAFDPAGATLAQTVKWNLWGYTTRTKVSLVRTAVAVLFTAAGTYLDTALAIRGVEPYGAAVYAGVWVVAALVTGLSLRYVGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PS22</accession>
    <name>A0AAN6PS22_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_12617</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the major facilitator superfamily. CAR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854323">
        <property type="protein sequence ID" value="KAK4043876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PS22"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000509">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF163">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="301"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="345"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="389"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="414"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="445"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="479"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="68"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4043876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="518" mass="55784" checksum="3A34DDE04B38E4F4" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PS69</accession>
    <name>A0AAN6PS69_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Peptidase S8/S53 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_32034</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854323">
        <property type="protein sequence ID" value="KAK4043936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PS69"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04843">
        <property type="entry name" value="Peptidases_S8_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034073">
        <property type="entry name" value="Subtilisin_DY-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF11">
        <property type="entry name" value="CEREVISIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042853604" evidence="6">
        <location>
            <begin position="24"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="7">
        <location>
            <begin position="235"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4043936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="492" mass="51866" checksum="D8BAD515409C6375" modified="2024-10-02" version="1">MGLTRSLALGLLCALPLFNAVLAAPTLPRNDAAAPRSAIAIKLNKSTTRARSVAGADLVEDLIRKAQSGSGHAKRDVQFNVLPLITSLTPEKISDMVQRATTLDPTYEPADFSSWFRVQFSESTGDEGDAELTELLSNLAVFQEVASCQRLAHTKAPAVQPNDDPLFSTQGYLTGDGVGINAVYAWGFPGGDGAGTTIIDVEAGWKLTHEDLVAQNITLLAGMNVLDRYGANWPHGTAVLGEILMSDNTVGGVGIAHAARGHVVGIQRTNEDGGPVENEPEAIMDAASHLSPGDVMLLEMQTGDANNNLWPIEILDAQFEAIRLATAMGIVVIEPTGNGGQDMDQPVLRVGDTTARALLNRNSPDFRDSGAIMVGAGSSTLPRSRLYFSNYGNRVDVHSWGENIATSSVVAEDWSNDDTYTNFDGTSGAAPIIAGAALSIQGMVSANRGSKLTPAEMRSLITVGGTATSDPSTDRIGVQPDLRALIDGGYLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PSB4</accession>
    <name>A0AAN6PSB4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_12518</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854322">
        <property type="protein sequence ID" value="KAK4043996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PSB4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000171">
        <property type="term" value="F:ribonuclease MRP activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034965">
        <property type="term" value="P:intronic box C/D snoRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013241">
        <property type="entry name" value="RNase_P_Pop3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28272">
        <property type="entry name" value="RIBONUCLEASES P/MRP PROTEIN SUBUNIT POP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28272:SF1">
        <property type="entry name" value="RIBONUCLEASES P_MRP PROTEIN SUBUNIT POP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08228">
        <property type="entry name" value="RNase_P_pop3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4043996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="246" mass="26473" checksum="A3F2F0867AA3AB17" modified="2024-10-02" version="1">MERKRIVHTLDTPYSAVEWPQISQDDQDAILELLCQLLAPLGAHRRSFITPSKGKRKRSKKAGSPEKPAEATPALTAPPLPELAAHVDVGLSHISRALQGMSGKDKPSPPPIATPSERTEEEPKADANPYSVVFVARSGQSSAFHCHFPQMVALAAQSQPADKAVRLVGLSKACEDRLSAALGIPRASSIGLREDAPQAKGLVDFVREHVAPVDVAWLREAPSGKFLETRIDAVPTNVGVKKPRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PSD6</accession>
    <name>A0AAN6PSD6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_31467</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854319">
        <property type="protein sequence ID" value="KAK4044414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PSD6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03751">
        <property type="entry name" value="proteasome_alpha_type_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000044">
        <property type="entry name" value="Probable proteasome subunit alpha type-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="1 2 3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="4">
        <location>
            <begin position="8"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4044414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="283" mass="30236" checksum="3B01A6FB79F4AD00" modified="2024-10-02" version="1">MTSIGTGYDLANSIFSPDGRNFQVEYAVKAVENGGTSIGIRCKDGVVLAVEKLVTSKLLKPSANKRIATVDRHLGVVYSGMIPDGRHFIDRARDEARAWRDTFKTPISTADLASRMGGYMQAYTLYQSVRPFGITAIVGGFDSTAEATVDGEVGAGPSCGAGGKVAGKTHGGPFLYMIEPSGLYWGYYGAATGKGRQAAKAELEKLDLGGPAGGPALTLEEAVKEAARIIYVAHDDDKEFELEMTWISGLDGPTKGLHQEVPKALREEAERLAKKAQEGKMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PSM2</accession>
    <name>A0AAN6PSM2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_12110</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854318">
        <property type="protein sequence ID" value="KAK4044564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PSM2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11069">
        <property type="entry name" value="CYP_FUM15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000051">
        <property type="entry name" value="Cytochrome P450 monooxygenase (Fum15)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF227">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="4">
        <location>
            <position position="481"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4044564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="541" mass="60391" checksum="C111BF98461D33E3" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SL58</accession>
    <name>A0AAN6SL58_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">UbiA prenyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_51554</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854865">
        <property type="protein sequence ID" value="KAK4031332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SL58"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13965">
        <property type="entry name" value="PT_UbiA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050475">
        <property type="entry name" value="Prenyltransferase_related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42723">
        <property type="entry name" value="CHLOROPHYLL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42723:SF1">
        <property type="entry name" value="CHLOROPHYLL SYNTHASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="256"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="286"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4031332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="308" mass="33394" checksum="26F01A4EF2BB137E" modified="2024-10-02" version="1">MTDVEPEGTEQQVRTPWFHLQSLLLFTRSDIKTSVLPQGVFAIGTALAGGQMTVAEVAVRIPIMLGWSWLHLLVFNIAGQRLATSILEDSINKPWRPLPSGRVSPAEAVRLLRPAIATAIIVSVTLGNYPASAACMIYGWIYNELDGSSAGPIERNFWNAVGLGCLGWGSAEALLGGHNSARLGNGALGTWLLLTSAVVFTTVHAQDMEDVVGDRARGRRTAPLVYGEAAARTLLAVSVLLWSVVCPVFWNVPHTTAIWYAPLCVGVAMADLTITRWDLASSKLMFNLWCAWLGLLYILPVFGLKHAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SM88</accession>
    <name>A0AAN6SM88_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_41071</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854605">
        <property type="protein sequence ID" value="KAK4032488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SM88"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013595">
        <property type="entry name" value="Pept_S33_TAP-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051601">
        <property type="entry name" value="Serine_prot/Carboxylest_S33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248">
        <property type="entry name" value="2-SUCCINYL-6-HYDROXY-2,4-CYCLOHEXADIENE-1-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248:SF25">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08386">
        <property type="entry name" value="Abhydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="5">
        <location>
            <begin position="191"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S33 tripeptidyl aminopeptidase-like C-terminal" evidence="6">
        <location>
            <begin position="557"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="173"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4032488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="660" mass="72559" checksum="B99FCF59C4524528" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SMD7</accession>
    <name>A0AAN6SMD7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_40905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854587">
        <property type="protein sequence ID" value="KAK4032652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SMD7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4032652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="64" mass="6558" checksum="0E37A50A9C95B062" modified="2024-10-02" version="1">MDDAAAERIRRARGDRDGFSKRAADAARRNEGQEQRDSSSKSGSGSSGGSRSAQKSGGSGGGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SMX0</accession>
    <name>A0AAN6SMX0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_40403</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854549">
        <property type="protein sequence ID" value="KAK4033148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SMX0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4033148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="533" mass="59563" checksum="499B6B5A297FC056" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SND9</accession>
    <name>A0AAN6SND9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_39803</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854513">
        <property type="protein sequence ID" value="KAK4033717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SND9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050829">
        <property type="entry name" value="CorA_MIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47685">
        <property type="entry name" value="MAGNESIUM TRANSPORT PROTEIN CORA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47685:SF1">
        <property type="entry name" value="MAGNESIUM TRANSPORT PROTEIN CORA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="725"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="765"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="799"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="91"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="863"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="915"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="668"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="100"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="875"/>
            <end position="884"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4033717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="934" mass="104699" checksum="C54BFD7856971382" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SNG2</accession>
    <name>A0AAN6SNG2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_49738</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854513">
        <property type="protein sequence ID" value="KAK4033718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SNG2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000335">
        <property type="entry name" value="Siderochrome iron transporter 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000284">
        <property type="entry name" value="Siderophore iron transporter mirB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="263"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="299"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="341"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="378"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="408"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="433"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="466"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="547"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4033718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="582" mass="63386" checksum="1B0110D54B6CEB3C" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SPI0</accession>
    <name>A0AAN6SPI0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transcriptional Coactivator p15-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_37802</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transcriptional coactivator PC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854434">
        <property type="protein sequence ID" value="KAK4038284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SPI0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060261">
        <property type="term" value="P:positive regulation of transcription initiation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.31.10">
        <property type="entry name" value="Transcriptional Coactivator Pc4, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003173">
        <property type="entry name" value="PC4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009044">
        <property type="entry name" value="ssDNA-bd_transcriptional_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045125">
        <property type="entry name" value="Sub1/Tcp4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13215">
        <property type="entry name" value="RNA POLYMERASE II TRANSCRIPTIONAL COACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02229">
        <property type="entry name" value="PC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54447">
        <property type="entry name" value="ssDNA-binding transcriptional regulator domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcriptional coactivator p15 (PC4) C-terminal" evidence="8">
        <location>
            <begin position="45"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="107"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="107"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4038284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="151" mass="16699" checksum="4B5F5BBDFFCB3B03" modified="2024-10-02" version="1">MPYNKKRQIDPESDGEQQVVKKPKNEKKAKKDLTQGTDAEGNPYWEIGNNRRIGSSQFKGATLVNIREYYTAPDGELRPGKKGISLSLDQYKALLKVIPELNEQLRSQGHQVDSTTAAGASNALVKADEPPKAKKSQKANIDATSDEEDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SPW0</accession>
    <name>A0AAN6SPW0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_37426</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854423">
        <property type="protein sequence ID" value="KAK4038659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SPW0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4038659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="137" mass="15034" checksum="A14935D8FDA06C9A" modified="2024-10-02" version="1">MPFDNENTSLNALADPSVLSTRADDEMDVDLNALTMSSCRKGYYAVENEKFHKASMLKPASNATQLMECDEFPRGASEDRDFGPAASHSNLCIARIQNNHGGQCISLLNMMSSNVGKMEAVDTPLGETRNDVSWIAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SPY3</accession>
    <name>A0AAN6SPY3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_38272</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854450">
        <property type="protein sequence ID" value="KAK4035250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SPY3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4035250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="372" mass="41964" checksum="620573A2D42E8BE6" modified="2024-10-02" version="1">MAAEEQQDAHAGKQQDSHAPEQVADPVSGAQQLKQDSKLAAKVKQLEQELSTTTAERDDIQLQRQRVTKYDLWMETGGPPGYYHLAENYRKIRWVLELYLAPRVPWSSLGPDTGDKLLLWTPKAKQFLDSDDETARVVFEAWIWHVLDDHVFSNTKGPWVGEVWNAYAKLERLGACNCDTDTDWNLRFHEWRNFTLGMIQDTKTMPPFTRRDPRLVVEALNQELRPFFQTQEGRTDAERDKIFSSIARIAVETDLAMQFDRTEWSVSFGHPETGALVGFPFDHRFMKNGIIAYSLDKEKTDGMLVDLVTSPVAVQRGLDRGYAYHTTTYVSRTLMSVIVDMDSRPKKAEGTSSGGGGDTGASGTLEDGDAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SQK4</accession>
    <name>A0AAN6SQK4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Dehydrase and lipid transport-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_36564</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts with coenzyme Q.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the COQ10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854400">
        <property type="protein sequence ID" value="KAK4039439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SQK4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048039">
        <property type="term" value="F:ubiquinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045333">
        <property type="term" value="P:cellular respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07813">
        <property type="entry name" value="COQ10p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044996">
        <property type="entry name" value="COQ10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005031">
        <property type="entry name" value="COQ10_START"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12901:SF10">
        <property type="entry name" value="COENZYME Q-BINDING PROTEIN COQ10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12901">
        <property type="entry name" value="SPERM PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03364">
        <property type="entry name" value="Polyketide_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Coenzyme Q-binding protein COQ10 START" evidence="5">
        <location>
            <begin position="90"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="121"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="45"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="123"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4039439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="299" mass="31947" checksum="4D039515344DF567" modified="2024-10-02" version="1">MAPRLPTPTRRLPAARIPLFSPSPLPIRPSSPHFAQARHLPQPKPTTTTTRRPLSTTAPRPWLLSALPNLTPGANHPPPPPKTLHARRLLPYPPAHVYTLIADIDSYTHFLPHCPHSRVTRWTTPKPTTSTTTTPSTPAQARSTAAAATQPPAGRDGTRHPALADLTVGWGPFTQTYTSRVYCVPGSVVEAVSGSAGTSIPADVLRAVGYGDADLQGGSGGEGKKMEGIFESLVTRWTVKPVPQQGGQEGGEWSQVTLSVTFQFSNPALGFAVGQLADEKVDEMVAAFEGRARQLYGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SQV4</accession>
    <name>A0AAN6SQV4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Armadillo-type protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_36810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854406">
        <property type="protein sequence ID" value="KAK4039247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SQV4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010473">
        <property type="entry name" value="GTPase-bd"/>
    </dbReference>
    <dbReference type="SMART" id="SM01140">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Formin GTPase-binding" evidence="2">
        <location>
            <begin position="338"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="707"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="844"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="323"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="444"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="707"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="876"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="892"/>
            <end position="902"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4039247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="910" mass="99605" checksum="E4174D5F4371F330" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SQZ1</accession>
    <name>A0AAN6SQZ1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">LSM complex subunit LSM4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LSM4</name>
        <name evidence="12" type="ORF">C8A01DRAFT_16951</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Binds specifically to the 3'-terminal U-tract of U6 snRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">LSm subunits form a heteromer with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854412">
        <property type="protein sequence ID" value="KAK4039050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SQZ1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097525">
        <property type="term" value="C:spliceosomal snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01723">
        <property type="entry name" value="LSm4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000024">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034101">
        <property type="entry name" value="Lsm4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027141">
        <property type="entry name" value="LSm4/Sm_D1/D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23338">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="11">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="79"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="97"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK4039050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="125" mass="13413" checksum="A36B08F1482D4193" modified="2024-10-02" version="1" fragment="single">LPLGLLNAAQGHPMLVELKNGETLNGHLVLCDTWMNLTLREVVQTSPEGDKFVRLPEVYVKGNNIKYLRVPDEIIDIVREQQSQQGGYRGGRGGQGRGDHGGRGGDRGRGGRGRGGGRGGRGRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SRE1</accession>
    <name>A0AAN6SRE1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_46812</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854392">
        <property type="protein sequence ID" value="KAK4039787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SRE1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37542">
        <property type="entry name" value="HELO DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37542:SF1">
        <property type="entry name" value="PRION-INHIBITION AND PROPAGATION HELO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="345"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4039787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="514" mass="56684" checksum="D3708154AADDBC0B" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SRU5</accession>
    <name>A0AAN6SRU5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ClpP/crotonase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_35164</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854369">
        <property type="protein sequence ID" value="KAK4040789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SRU5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000058">
        <property type="entry name" value="Enoyl-CoA hydratase/isomerase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF171">
        <property type="entry name" value="SD19268P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0843">Virulence</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4040789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="346" mass="37251" checksum="25BBEBBFEDBDA130" modified="2024-10-02" version="1">MPPRFTLALNASAALRTGRLAARHARCPYSIEANAGPLLRVTDLPAPNSGHIRILELNRPAARNAISRALLSSLRDEIDAVHAQYDAATGDEIPTPSWNKRFGGMAGDDQKGPTRALILASAVDTSFCAGADLKERKTFTQEETAAFLLTLRTILTSLSTLPIPTIAAISSLALGGGLELALAAHFRVLTSNAVVGLPETRLGIIPGAGGTYRLPALIGVPRARDLILTGRRVSAPEAYFLGLADRLVEVAPESEAQAREWEGLEDKEREKVVLDVARRSALSEAVRLAGEICEGGPVAVRAALRAVEEPREAVENDMYERVVRTEDRDEALRAFGEKRKPVFKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SSC2</accession>
    <name>A0AAN6SSC2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_35167</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854369">
        <property type="protein sequence ID" value="KAK4040792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SSC2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05120">
        <property type="entry name" value="APH_ChoK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF15">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="49"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4040792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="236" mass="27487" checksum="094394F789FE812A" modified="2024-10-02" version="1">MSTNQPEERREEGCFGLTFERKYYHRNGSFIKRSLRPREFRTGYRGLHVPRLGKERIKNEADSLRYIRQHTDIPVPTVYSDFEDDDAYYLVVEYVEGVGMNDLSDDQKAVVREELEGHLAKLKKLRSNRMGGPSGIVVPPYRVMRQTERDDWTLQAAEVDEYVFCHNDLSQHNVVVDPDTLKITGIIDWEYAGFYPARFEMPFYTRFGPSVALKDEVDDSAELLDFLESKNKDTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SSE1</accession>
    <name>A0AAN6SSE1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_34556</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854358">
        <property type="protein sequence ID" value="KAK4041359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SSE1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125">
        <property type="entry name" value="LP07818P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125:SF10">
        <property type="entry name" value="OS12G0136300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="9"/>
            <end position="54"/>
        </location>
    </feature>
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        <location>
            <begin position="172"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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            <end position="251"/>
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            <end position="236"/>
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            <end position="321"/>
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            <end position="444"/>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
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            <end position="554"/>
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        <location>
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            <end position="564"/>
        </location>
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        <location>
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            <end position="996"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="997"/>
            <end position="1012"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK4041359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1044" mass="114682" checksum="C63FB9CF7723FE09" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SSF2</accession>
    <name>A0AAN6SSF2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_46230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854377">
        <property type="protein sequence ID" value="KAK4040416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <location>
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            <end position="34"/>
        </location>
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            <begin position="1"/>
            <end position="11"/>
        </location>
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        <location>
            <begin position="17"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK4040416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="297" mass="32197" checksum="47D84E79ABB5EDAD" modified="2024-10-02" version="1">MPTTENDSNVEGQGKRLTTTSSLTPSPDSSLENLADRKDEGAMGTAITSPHPPFPVVMNAYGQWGKLKSFNLCGATEQDRLCHVDIHTGYSGKTPLGTRPGVVLHYGMSSKAPILAAAGYDSQWSASILSFNSESVILMPSLLPATARTSNFVTEKMPAFVRGGQVVFSFSIEVSHGKEPRREKFEWRKFAKDVDETAKEGGFKLVRLPSPRSSTKLADDTDADAGSEVLALLAWRQLFPKFKHAFTLQLLGRGQSGELGERWSLMVVITALRLWALRVAGKTKKGVIAAGQKADGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2025-10-08" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6STL5</accession>
    <name>A0AAN6STL5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Non-specific serine/threonine protein kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_14639</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Associates with DNA double-strand breaks.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PI3/PI4-kinase family. TRA1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ARM-like"/>
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        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046807">
        <property type="entry name" value="Tra1_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046805">
        <property type="entry name" value="Tra1_ring"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF1">
        <property type="entry name" value="TRANSFORMATION_TRANSCRIPTION DOMAIN-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20175">
        <property type="entry name" value="Tra1_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20206">
        <property type="entry name" value="Tra1_ring"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAT" evidence="6">
        <location>
            <begin position="2676"/>
            <end position="3231"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="5">
        <location>
            <begin position="3491"/>
            <end position="3837"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="7">
        <location>
            <begin position="3834"/>
            <end position="3866"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="165"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2038"/>
            <end position="2074"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="3239"/>
            <end position="3315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="184"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="3250"/>
            <end position="3261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="3301"/>
            <end position="3312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4041676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="3866" mass="440188" checksum="B1F77A3499E174A4" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6STN5</accession>
    <name>A0AAN6STN5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Phospholipase C/P1 nuclease domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_45169</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nuclease type I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854352">
        <property type="protein sequence ID" value="KAK4041736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6STN5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11010">
        <property type="entry name" value="S1-P1_nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.575.10">
        <property type="entry name" value="P1 Nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008947">
        <property type="entry name" value="PLipase_C/P1_nuclease_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003154">
        <property type="entry name" value="S1/P1nuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33146">
        <property type="entry name" value="ENDONUCLEASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33146:SF26">
        <property type="entry name" value="ENDONUCLEASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02265">
        <property type="entry name" value="S1-P1_nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48537">
        <property type="entry name" value="Phospholipase C/P1 nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4041736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="301" mass="33045" checksum="B897E56A405C4C9A" modified="2024-10-02" version="1">MKLSSFAVATAAVPGALAWGGFGHISVAYLASNFVSPATTSYLQSLLRNDTGDYLAGVAAWADSVRYTKWGRFTSDFHFIDAKDDPPRYCGVDFERDCKKDRGCVVSALHNYTSRMLDPDLEAAERAIAAKFVVHFVGDMHQPLHTENVARGGNGIPVRFDRRNYNLHHVWDTSIAEKLVGGVPRRGGPYAVAKRWADELTKQINEGKFATDRIDWLRSANLSDPRATAMAWATEGNAYVCTTVLPDGPEAIKGQELGSKYFEAAAPVVEVQVARAGYRLAAWLDLIVSSLKTDRSLSDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6STT6</accession>
    <name>A0AAN6STT6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF952 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_34161</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854351">
        <property type="protein sequence ID" value="KAK4041783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6STT6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.170.20">
        <property type="entry name" value="Protein of unknown function DUF952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009297">
        <property type="entry name" value="DUF952"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34129">
        <property type="entry name" value="BLR1139 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34129:SF1">
        <property type="entry name" value="DUF952 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06108">
        <property type="entry name" value="DUF952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4041783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="130" mass="14586" checksum="A032E8228F500F1C" modified="2024-10-02" version="1">MAPLPPPSPLPEYVYKITPSAPPTPIPEQYPLSDLDQQDGFVHLSASWQVPITASLFFKDTPSFHILKLRLARFDAAAVKWDEVDGTNGCPHLYGNFGADDVVSVREFRRGEGQTWQEVFEGEAERGWLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6STX0</accession>
    <name>A0AAN6STX0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">C8A01DRAFT_32892</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="2"/>
    <dbReference type="EMBL" id="MU854333">
        <property type="protein sequence ID" value="KAK4042949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6STX0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20346">
        <property type="entry name" value="BRcat_RBR_ANKIB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20356">
        <property type="entry name" value="Rcat_RBR_HHARI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16625">
        <property type="entry name" value="RING-HC_RBR_HEL2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1750:FF:000007">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000019">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045840">
        <property type="entry name" value="Ariadne"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048962">
        <property type="entry name" value="ARIH1-like_UBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19422">
        <property type="entry name" value="Ariadne"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22191">
        <property type="entry name" value="IBR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21235">
        <property type="entry name" value="UBA_ARI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="135"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="139"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK4042949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="528" mass="60485" checksum="7BB84F42845BF769" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SU93</accession>
    <name>A0AAN6SU93_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Methionine aminopeptidase 2</fullName>
            <shortName evidence="8">MAP 2</shortName>
            <shortName evidence="8">MetAP 2</shortName>
            <ecNumber evidence="8">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">C8A01DRAFT_14034</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 9">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="8">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="8"/>
    <dbReference type="EMBL" id="MU854342">
        <property type="protein sequence ID" value="KAK4042351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SU93"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004239">
        <property type="term" value="F:initiator methionyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01088">
        <property type="entry name" value="MetAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03175">
        <property type="entry name" value="MetAP_2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050247">
        <property type="entry name" value="Met_Aminopeptidase_Type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002468">
        <property type="entry name" value="Pept_M24A_MAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00501">
        <property type="entry name" value="met_pdase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45777">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45777:SF1">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 2-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8 9" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M24" evidence="11">
        <location>
            <begin position="121"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="46"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="420"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="420"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK4042351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="439" mass="48449" checksum="1CD62C2F825A8812" modified="2024-10-02" version="1">MCGGEPRGAQMSRAGDGVLGSGGDDEESDGDGGEVDPAAADAGATQKKRKKRNKKKSKKKTKPDSPVEQTSPPRIPLDQLFPSGEFPEGEVQSYQATARTTAAERRHDSRQYWEDEAFLKNYRKAAEIHRQTRRWVQETAKPGQSLHDIAVGIEDSVRALLDNAGLEPGDGLKSGMGFPTGLCLNNQVAHYTPNPGQKPVVLQQQDVLTVDFGVHINGWIVDSAFTTAFDPTYDNLLAAVKDATNTGVKTAGIDVRISDVSAAIQEVMESYEVEIRGKTYRVKPVRNLSGHNIKQYHIHGGKSIPFVKTRDQTKMEEGEVFAIETFGTTGRGYIVDDVGVYGYGLNHDAPLNVPVSLSSAKRLHKTIRENFGTIVFCRRYLERLGVEKYLAGMNCLIQHGVVEEYGPLMDVKGSYSAQFEHTFLLRETHKEIFSRGDDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SU97</accession>
    <name>A0AAN6SU97_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Fumble-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_44511</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854340">
        <property type="protein sequence ID" value="KAK4042500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SU97"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004594">
        <property type="term" value="F:pantothenate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd24123">
        <property type="entry name" value="ASKHA_NBD_PanK-II_Pank4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000115">
        <property type="entry name" value="Pantothenate kinase PanK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.510:FF:000005">
        <property type="entry name" value="Probable pantothenate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004567">
        <property type="entry name" value="Type_II_PanK"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00555">
        <property type="entry name" value="panK_eukar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12280:SF20">
        <property type="entry name" value="4'-PHOSPHOPANTETHEINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12280">
        <property type="entry name" value="PANTOTHENATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03630">
        <property type="entry name" value="Fumble"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="273"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="377"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="408"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="459"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="727"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="738"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="760"/>
            <end position="779"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4042500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="879" mass="96694" checksum="9CFC8524EECABCC2" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SUA8</accession>
    <name>A0AAN6SUA8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Protein HIR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">C8A01DRAFT_33559</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the WD repeat HIR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854342">
        <property type="protein sequence ID" value="KAK4042353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SUA8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000417">
        <property type="term" value="C:HIR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000290">
        <property type="entry name" value="Protein HIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001557">
        <property type="entry name" value="Protein HIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055410">
        <property type="entry name" value="Beta-prop_CAF1B_HIR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031120">
        <property type="entry name" value="HIR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011494">
        <property type="entry name" value="HIRA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019015">
        <property type="entry name" value="HIRA_B_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13831">
        <property type="entry name" value="MEMBER OF THE HIR1 FAMILY OF WD-REPEAT PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13831:SF0">
        <property type="entry name" value="PROTEIN HIRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24105">
        <property type="entry name" value="Beta-prop_CAF1B_HIR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07569">
        <property type="entry name" value="Hira"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09453">
        <property type="entry name" value="HIRA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="10 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0678">Repressor</keyword>
    <keyword evidence="9 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="8 12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5 11 12" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="CAF1B/HIR1 beta-propeller" evidence="15">
        <location>
            <begin position="28"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="66"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="127"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="169"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Protein HIRA-like C-terminal" evidence="14">
        <location>
            <begin position="724"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="430"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="861"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1047"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="441"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="861"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1060"/>
            <end position="1070"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF24105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK4042353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1070" mass="114884" checksum="594AE536D36D794B" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SUD2</accession>
    <name>A0AAN6SUD2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PARP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_33410</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854340">
        <property type="protein sequence ID" value="KAK4042471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SUD2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1740.10">
        <property type="entry name" value="Zinc finger, PARP-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001510">
        <property type="entry name" value="Znf_PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036957">
        <property type="entry name" value="Znf_PARP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00645">
        <property type="entry name" value="zf-PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01336">
        <property type="entry name" value="zf-PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50064">
        <property type="entry name" value="ZF_PARP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PARP-type" evidence="7">
        <location>
            <begin position="18"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="107"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="107"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="147"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="183"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="259"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="369"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="400"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="472"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4042471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="481" mass="53087" checksum="D24AEE270E72430B" modified="2024-10-02" version="1">MSYRIEISPTSRAGCKVTACKEAGAKIMKGEIRLGIWVVYPGGGEGWTWRHWGCVSGEQIVNMQNEIGQEFNGEYRWDAIDGWEDLEDRPDVREKIKRVITQGHIDPEDFKGMIKDPEMNVPGQRGIHRRKKKVKPEPEPEPEDGDEVKQEIKHEIKDEIKDEVKHKIKEEPGSEPELEKPKKAAGKRARGKKAQDDEEEAYEPQPPAKKAKRAPKIKAEPSPELGTTPEKPKRATRGNRGAKAAPAIKEESEAEAEADVEREPTPEKPKRAARGRRGAKVADVAVKEENDSEMELEAAPDKPKRAAKGKRGAKAAVAVKEESEAEVEPEATPEKPKRAARGKRGAKVADIAVKEENDSEMEFEAAPVKPKRATTGKRGAKAAAKEVDEAPESETEPPKKRAGRARKVKKEPSLEPSPEPSPEAQVKMESEAESGFMPATESETASEPEEEEPAPKAKRGRKVVEKKPAPAPKRRGRKAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SUU1</accession>
    <name>A0AAN6SUU1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Replication factor A protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_13496</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the replication factor A protein 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854334">
        <property type="protein sequence ID" value="KAK4042921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SUU1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005662">
        <property type="term" value="C:DNA replication factor A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04479">
        <property type="entry name" value="RPA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013970">
        <property type="entry name" value="Rfa2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15114:SF1">
        <property type="entry name" value="REPLICATION PROTEIN A 14 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15114">
        <property type="entry name" value="REPLICATION PROTEIN A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08661">
        <property type="entry name" value="Rep_fac-A_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4042921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="104" mass="11110" checksum="782260E05DCCFAE8" modified="2024-10-02" version="1">MEAIASPRITCAYLNTYVGKNVIIVGKVIQLRGEEALIDADGNITAHLNREAHLLAGNGAQIIGKVNPDLSIKVLSSMDLGTGVDYNLANSVVEISHQHRSLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SUX7</accession>
    <name>A0AAN6SUX7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA pseudouridine(55) synthase</fullName>
            <ecNumber evidence="3">5.4.99.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_13390</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a uridine in mRNA = a pseudouridine in mRNA</text>
            <dbReference type="Rhea" id="RHEA:56644"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:14659"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pseudouridine synthase TruB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.25" evidence="3"/>
    <dbReference type="EMBL" id="MU854332">
        <property type="protein sequence ID" value="KAK4043026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SUX7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160148">
        <property type="term" value="F:tRNA pseudouridine(55) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2350.10:FF:000014">
        <property type="entry name" value="PUS4p Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01080">
        <property type="entry name" value="TruB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002501">
        <property type="entry name" value="PsdUridine_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014780">
        <property type="entry name" value="tRNA_psdUridine_synth_TruB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032819">
        <property type="entry name" value="TruB_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13767:SF2">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE TRUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13767">
        <property type="entry name" value="TRNA-PSEUDOURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16198">
        <property type="entry name" value="TruB_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01509">
        <property type="entry name" value="TruB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pseudouridine synthase II N-terminal" evidence="7">
        <location>
            <begin position="69"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA pseudouridylate synthase B C-terminal" evidence="8">
        <location>
            <begin position="347"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="231"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="407"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="315"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="424"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4043026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="495" mass="54270" checksum="3952D63590E64D45" modified="2024-10-02" version="1">MAANKVLEGVFAINKPFGMSSAQVIRDCQEYFNPSSLFAPLIEQDKALREKESRYQKHRRGKSKQAVRVKMGHGGTLDPLATGVLILGVGKGTKALQNFLTCTKTYETVVLFGASTDTYDRTGRIIKKGHYDDVTRQAAEAALDGFRGKIRQMPPLYSALKMEGKPLYEYAREGKPIPREIETREVEVAELDLVEWYEPGTHNHRWPTEEAEQAEKNLVDSVWRVAKRQQAATDGELKLTPEQQEEEAKALAEYNSKKREAEERVDSLVSDEQQQAQPQQPPAKRKKTNAGRAEPMMSGALGKLPPKGKGSDLVPPSPAPDTPPPWEGKGPAAAKIRMTVTSGFYVRSLCHDLGEKLGCGAMMAELSRTRQGQFVLEGENCMEYDELLKGEEVWGPKVHRMLDLWNNPNAKAEPKSGEASAAAEEAKGPEESKPAEEGKGAQEDKPTEGCRLPEEKAAEESKLVEDAKPADPVPEPEAASAEPAAEEEPAAAASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SUY9</accession>
    <name>A0AAN6SUY9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7730 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_31687</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854321">
        <property type="protein sequence ID" value="KAK4044089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SUY9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056632">
        <property type="entry name" value="DUF7730"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24864">
        <property type="entry name" value="DUF7730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7730" evidence="2">
        <location>
            <begin position="143"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4044089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="380" mass="42698" checksum="F90A2D0252D4BFDA" modified="2024-10-02" version="1">MAARSVNTASFDRSADPQLSSPFFALLPAEIRNLIYLEFWNLCSTRQHVVKNQIPDEDNAEGFNEWSHVPCLVDPRAEDTRFDEFATSAPASAERNPWGKRLKSEWCLHWACEEQVHDASKTVRGMGREMSESLGESSDDVAAASGSQTAEQQTTHESAGCQASTKTGLLSLATTCKRMYLESLLSLYSSTTFVLTDTRTAEEFLSRYGNDPERYPIRSLEICIRVPNIITEIYYPPAHSNGDEGPPAIFAGRARPMLSMKNNPWQHLCDALVALPNLQDLRVWLDSSDLRPWHKRVSETRFFARLCDVRGPDKARFVLGLPELPERRGPDSHALEGQYLEGEKLDDVPFMVERGPRPNNWRMHLRSIVSAGAAAFPAQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SUZ8</accession>
    <name>A0AAN6SUZ8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_32567</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854329">
        <property type="protein sequence ID" value="KAK4043250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SUZ8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043484">
        <property type="term" value="P:regulation of RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051175">
        <property type="entry name" value="CLK_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE DOA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646:SF11">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE DOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="38"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="393"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4043250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="413" mass="46764" checksum="ADB23E3EF110F95C" modified="2024-10-02" version="1">MLPNDWSLDIGNETEKLEKYHEGGFCPIQLGECIADRFTILHKLGHGGFGTVWLVRDAANRHGRYVALKVVSAEYSEDYEPAAVLDRLKKYERDHGSPGVFLVELERLFHTNFTLKNVALKLWESLEPLTEQELLADDMFGTPLGAANLILPRGYLSTRICILDFDQAFLTDNAPREVPYIPAPYLALEFIFTLTNSPAADVWALGCVLFNLRYPMQLFWDFSASDAEATAKTICYTLGPLPKEWMAVPFLDGWPVHEPLEPDTQGKPEAIKLVDHSNDKCSLEDVVDGIREPRPPASSTSQKPRTGLEYFCLQVPKIDFRDHAGKERFEAEKTRPIPKEDAKPFVDLTRKMFNYDYTKRITARQVLEHPWMRETGQKTRAPGALLMGAHDASLPLRTNRPMDKSQATQQAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SV08</accession>
    <name>A0AAN6SV08_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MIF4G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_32597</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic initiation factor 4G family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854329">
        <property type="protein sequence ID" value="KAK4043280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000020">
        <property type="entry name" value="Eukaryotic translation initiation factor subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.970.30:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor subunit eIF-4F, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.970.30">
        <property type="entry name" value="eIF4G, eIF4E-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022745">
        <property type="entry name" value="eIF4G1_eIF4E-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036211">
        <property type="entry name" value="eIF4G_eIF4E-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
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        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23253:SF9">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12152">
        <property type="entry name" value="eIF_4G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101489">
        <property type="entry name" value="Eukaryotic initiation factor 4f subunit eIF4g, eIF4e-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="MIF4G" evidence="9">
        <location>
            <begin position="1158"/>
            <end position="1400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="142"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="501"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="990"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1405"/>
            <end position="1576"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="44"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="230"/>
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        </location>
    </feature>
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            <begin position="523"/>
            <end position="544"/>
        </location>
    </feature>
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        <location>
            <begin position="548"/>
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        <location>
            <begin position="592"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="654"/>
            <end position="747"/>
        </location>
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        <location>
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        <location>
            <begin position="1501"/>
            <end position="1510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005775"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4043280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1576" mass="167210" checksum="96606F341F492EE2" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SV84</accession>
    <name>A0AAN6SV84_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">E3 ubiquitin protein ligase</fullName>
            <ecNumber evidence="15">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">C8A01DRAFT_32434</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">E3 ubiquitin-protein ligase that mediates monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 15">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the BRE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="15"/>
    <dbReference type="EMBL" id="MU854327">
        <property type="protein sequence ID" value="KAK4043505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SV84"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033503">
        <property type="term" value="C:HULC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16499">
        <property type="entry name" value="RING-HC_Bre1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058643">
        <property type="entry name" value="BRE1-like_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013956">
        <property type="entry name" value="E3_ubiquit_lig_Bre1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23163:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE BRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23163">
        <property type="entry name" value="RING FINGER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08647">
        <property type="entry name" value="BRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26095">
        <property type="entry name" value="CC_Bre1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 15" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="11 15 16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 15" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9 15" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 14 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="18">
        <location>
            <begin position="654"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="223"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="160"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="253"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="312"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="546"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU365038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAK4043505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="706" mass="79445" checksum="8CF1EAC2443489E3" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SVF1</accession>
    <name>A0AAN6SVF1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_43632</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854327">
        <property type="protein sequence ID" value="KAK4043508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SVF1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="116"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="444"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="293"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4043508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="494" mass="52211" checksum="2A5CFC1ED2C51C13" modified="2024-10-02" version="1">MAIPRAVPAVLGAVAFLPTTAILAIHIILARSPADRAPSVRITAIVATVLEAVIFVALPFLSISHVAPWAPSARLGCWRRIWYGAGLALCTVASAVSVATIVCLSQVVDDPLSTILGLGVGSFLVGSSVALGLAFATQLVFFVFHFIAGRALGSHPEISTHAEQGNNKSGPRIKTVPYHETTPTSAKDRGSVSFDSPTPPGSSGGRSRSETMSSIRTSLSHAIRPITSRTRLLSISRPSAHRPASLDLAAPQDRQSRSTEVGFDSWDTSAVDPENRQTVLESSSPPPGRFLETIPASPTTSRSPSPGTALDMLEPPRTRRRSRSYSPVSTRTINAQRAAFTQQASPSEAHIHPLFRSDSPKPPSATPGTVVVAAPNAGQVIAGDKQSIRSIQSMRRLRSESLPPAPSPLSRAGSCDSFVQHRRAGSTSPEITEEEDEAVDVAAGVDTERKMTPPIPDYILNAGPRSSLTVYKSRKDEIPSGGEDASGLEQQATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SVQ1</accession>
    <name>A0AAN6SVQ1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Stress-activated map kinase interacting protein 1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_31873</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIN1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854322">
        <property type="protein sequence ID" value="KAK4044000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SVQ1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038203">
        <property type="term" value="P:TORC2 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000263">
        <property type="entry name" value="Stress activated MAP kinase interacting protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031567">
        <property type="entry name" value="CRIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008828">
        <property type="entry name" value="Sin1/Avo1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031313">
        <property type="entry name" value="Sin1_PH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13335">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX 2 SUBUNIT MAPKAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13335:SF1">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX 2 SUBUNIT MAPKAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16978">
        <property type="entry name" value="CRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16979">
        <property type="entry name" value="SIN1_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CRIM" evidence="3">
        <location>
            <begin position="335"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="SIN1-type PH" evidence="4">
        <location>
            <begin position="702"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="84"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="232"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="490"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="116"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="183"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="245"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4044000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="807" mass="89422" checksum="4EBF6EE9E140380A" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SVQ6</accession>
    <name>A0AAN6SVQ6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_42478</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAP domain-containing ribonucleoprotein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854316">
        <property type="protein sequence ID" value="KAK4044869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SVQ6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052240">
        <property type="entry name" value="SAP_domain_ribonucleoprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46551">
        <property type="entry name" value="SAP DOMAIN-CONTAINING RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46551:SF1">
        <property type="entry name" value="SAP DOMAIN-CONTAINING RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="4">
        <location>
            <begin position="4"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="15"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="158"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="214"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="231"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00046328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4044869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="304" mass="31237" checksum="5B4E872CAD05D137" modified="2024-10-02" version="1">MADYNSMKVPELKKLLTERSLPHTGNKADLIARLTEDDKQKAAGSTEAQADSKPPVEDEIDYEDDDLPATKKDAVAAATTTEPKADSAAAPEEPTKTDEATTAAAEESTQPAATSTAAAEEEPAKPAFSQNLPPTNAKSEAEKRAARAARFGVPAAVEEGKEAKEEEQTDEAKKAARAARFGVANDQVSALDSALPDRPRKRGRGAAAAGEGEGAAKEEEGGRGGKRANRGGAGAGGGGRNQQQQQQRRGGRGQGGRRQGGGGGGGRGGNAQKGGEKGPARVVDPAEKAKMEARAKRFATAASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2025-10-08" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SVV6</accession>
    <name>A0AAN6SVV6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_12051</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854318">
        <property type="protein sequence ID" value="KAK4044482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903479">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21206">
        <property type="entry name" value="CH_IQGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05127">
        <property type="entry name" value="RasGAP_IQGAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000593">
        <property type="entry name" value="RasGAP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149:SF14">
        <property type="entry name" value="CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03836">
        <property type="entry name" value="RasGAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143885">
        <property type="entry name" value="RGC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="4">
        <location>
            <begin position="276"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GAP" evidence="3">
        <location>
            <begin position="1025"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="702"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="25"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="104"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="117"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="140"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4044482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1661" mass="189956" checksum="1D5E1A37185CA9A5" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P5C9</accession>
    <name>A0AAN6P5C9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WD-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_20823</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854656">
        <property type="protein sequence ID" value="KAK4032056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P5C9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046925">
        <property type="entry name" value="WD-like_fungi"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20493">
        <property type="entry name" value="WD-like_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042863373" description="WD-like domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="WD-like" evidence="2">
        <location>
            <begin position="74"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4032056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="182" mass="19375" checksum="B3AAB59BCDFA8C1D" modified="2024-10-02" version="1">MKTFTAILALAASTALGAAVPTPAEGSIAEPQAHNLTLVLGTDDFGEPVWRLLDENIPAHLQRRGASTAEPQPQGLVKRAAECHGNNRAYSDDCRTLANSIQYSKSPVPNSPRNIAYATCYISWSKVFSGEQSRFWAGAIDTLYDCTGGRAGDDHNYVSGVIRGYLPNGAAQCLSNRATGCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P5J3</accession>
    <name>A0AAN6P5J3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_51647</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU855193">
        <property type="protein sequence ID" value="KAK4031145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P5J3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4031145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="98" mass="11574" checksum="3DD5F73A9110F1A6" modified="2024-10-02" version="1">MIVDLTNFRFNLIYNLNNILAITIGKSLNKLVYSFKPRSILDFVNAKKERIDYASTIAKIYYNDKYIPTEFEKDNIVRLFKIVYRVDSNTYKLDFSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P5V2</accession>
    <name>A0AAN6P5V2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Cellulase</fullName>
            <ecNumber evidence="3 10">3.2.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">C8A01DRAFT_20589</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 45 (cellulase K) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.4" evidence="3 10"/>
    <dbReference type="EMBL" id="MU854623">
        <property type="protein sequence ID" value="KAK4032328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P5V2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052288">
        <property type="entry name" value="GH45_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000334">
        <property type="entry name" value="Glyco_hydro_45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39730">
        <property type="entry name" value="ENDOGLUCANASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39730:SF1">
        <property type="entry name" value="ENDOGLUCANASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02015">
        <property type="entry name" value="Glyco_hydro_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01140">
        <property type="entry name" value="GLYCOSYL_HYDROL_F45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043017046" description="Cellulase" evidence="12">
        <location>
            <begin position="22"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="13">
        <location>
            <begin position="304"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="220"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="237"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="276"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK4032328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="340" mass="35176" checksum="6D0CFA6A29A4AD8A" modified="2024-10-02" version="1">MRTTPILRTALAAALPLVAYAADGKSTRYWDCCKPSCSWPGKALVKQPVYACSANFQRITDPNAKSGCDGGSAFSCADQTPWALNDDFAYGFAATALSGGSEATWCCGCYELTFTSGPVAGKKMIVQSTSTGGDLGSNHFDLNIPGGGVGIFDGCSAQVGGLGGQRYGGVSSRSECDSFPEALKPGCYWRFDWFKNADNPNFTFRQVQCPAELVARTGCRRDDDSSFPAVDAPGGNSQPTSPASSPSPIASSSSSSSSSNVPPSSTSTPVSPPQPTTTSTSSVSPTKPTSTSTSPSKSPSSASCVTQKYGQCGGNGFAGCKTCVCGTTCQKQNDWYSQCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P7Q0</accession>
    <name>A0AAN6P7Q0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_21490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854918">
        <property type="protein sequence ID" value="KAK4031266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P7Q0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4031266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="53" mass="5955" checksum="A70F0BC1B04D8689" modified="2024-10-02" version="1" fragment="single">RRYVIVPSSNKCSGYIRLGKKYSSPNIASARKSRLSSYSLRLIPSSNSEYISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P891</accession>
    <name>A0AAN6P891_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Peptidase S8/S53 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">C8A01DRAFT_41378</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854638">
        <property type="protein sequence ID" value="KAK4032183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P891"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019863">
        <property type="term" value="F:IgE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04077">
        <property type="entry name" value="Peptidases_S8_PCSK9_ProteinaseK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.80:FF:000006">
        <property type="entry name" value="Autophagic serine protease Alp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000007">
        <property type="entry name" value="Subtilisin-like serine protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="entry name" value="Peptidase S8 propeptide/proteinase inhibitor I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034193">
        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010259">
        <property type="entry name" value="S8pro/Inhibitor_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF11">
        <property type="entry name" value="CEREVISIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05922">
        <property type="entry name" value="Inhibitor_I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
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</entry>
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
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                <person name="Kruys A."/>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">CBS 284.82</strain>
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    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </dbReference>
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        </location>
    </feature>
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        </location>
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    <feature type="compositionally biased region" description="Pro residues" evidence="1">
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
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    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK4033766.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P916</accession>
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    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
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                <person name="Guillou S."/>
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                <person name="Haridas S."/>
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                <person name="Pangilinan J."/>
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                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854559">
        <property type="protein sequence ID" value="KAK4032990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P916"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03368">
        <property type="entry name" value="Ribosomal_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000099">
        <property type="entry name" value="Ribosomal protein S12, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_uS12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005679">
        <property type="entry name" value="Ribosomal_uS12_bac"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00981">
        <property type="entry name" value="rpsL_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01034">
        <property type="entry name" value="RIBOSOMALS12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="159"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4032990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="170" mass="18134" checksum="165397A241C4A815" modified="2024-10-02" version="1">MATAFLRNLVLRPALRPALPKPSPPTPMLARAFSTTPSQSATLNQVLRGCRKQQRARHAVSPALSAIQAPSLKGVCVKVGITKPKKPNSGERKTARVRLSTGKVITAYIPGEGHNIQQHSVVLVRGGRSQDCPGVRYHLVRGALDLGGVGSRMSSRSKYGTKKPKKASVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P942</accession>
    <name>A0AAN6P942_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Kh domain-protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_19936</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854553">
        <property type="protein sequence ID" value="KAK4033082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P942"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd22385">
        <property type="entry name" value="KH-I_KHDC4_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22386">
        <property type="entry name" value="KH-I_KHDC4_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000037">
        <property type="entry name" value="KH domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000051">
        <property type="entry name" value="Putative kh domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055256">
        <property type="entry name" value="KH_1_KHDC4/BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047890">
        <property type="entry name" value="KHDC4_KH-I_first"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047889">
        <property type="entry name" value="KHDC4_KH-I_second"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056149">
        <property type="entry name" value="PRP5/DDX46/KHDC4_KH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031121">
        <property type="entry name" value="RIK/BLOM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055429">
        <property type="entry name" value="TRAPPC13_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055427">
        <property type="entry name" value="TRAPPC13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15744">
        <property type="entry name" value="BLOM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15744:SF0">
        <property type="entry name" value="KH HOMOLOGY DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22675">
        <property type="entry name" value="KH-I_KHDC4-BBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23469">
        <property type="entry name" value="KH_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23647">
        <property type="entry name" value="TRAPPC13_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06159">
        <property type="entry name" value="TRAPPC13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="3">
        <location>
            <begin position="234"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="328"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="438"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="675"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="98"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="338"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="367"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="438"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="449"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="676"/>
            <end position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4033082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="881" mass="94383" checksum="6892A928FA58E602" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P953</accession>
    <name>A0AAN6P953_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_41495</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854654">
        <property type="protein sequence ID" value="KAK4032076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P953"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90257">
        <property type="entry name" value="Myosin rod fragments"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="120"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="19"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="38"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4032076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="281" mass="29803" checksum="7F822D375766D4AE" modified="2024-10-02" version="1">MSASFNKPGKALRMAPREPAAPMPPAPGPSTQPPRQLPSTAASSTSSTNGTNGTNANAPTPSSAAGGAGRPGTPAGSSSRAPNRSSPPPKTDAHLAKSSSGIDVLRQTAAQNIQLANHGLGALSKQIAAAQRTAADLAERNKEVLKLKELLDRFDKEMKALRGEKDGLDKKVKDLTGEKEGLDKQLKSLSGEKERLEKKVGELGGEKDKLEKRVQGLEGDVDGLKQDVDQLVKENRTWEQDYYLLVDSLDEPEKALVEITQQLVESNTLLENLLGMTAVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P9T7</accession>
    <name>A0AAN6P9T7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Signal recognition particle receptor subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">C8A01DRAFT_39137</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SRP receptor beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854481">
        <property type="protein sequence ID" value="KAK4034411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P9T7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019009">
        <property type="entry name" value="SRP_receptor_beta_su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09439">
        <property type="entry name" value="SRPRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="73"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="84"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK4034411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="346" mass="36613" checksum="8450A449CC51858E" modified="2024-10-02" version="1">MTVLDTLKAAFEASLAPSPTVIAVGLAIVLFIPVLLHLLFSATTPYTTLPSVLLIGPPGAGKTALLTLFERGPLYNPDNRKEPDDQENPDNEEPPLDKPTVADPVAKTHTSQVPSTVELAVATDPNPSTTYRTDLDATGATAKKFLLVDTPGHPKLRRHALSHLQGSSSPTITPSALSPSSSETHKSKLKALVFVVDAAALGADSDDTGGLAATAEYLYDVLITLQKRFHRRSGSRAPASVPVLVAANKLDLFTALPAALVKSNLEAELGRIRKTRSKGLLDSGEGGGDGDAGAEEGEGWLGGYGTEKFSFKEMMEFDIEVEVIGGNVLGEGPGADKWWKWIGERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P9U5</accession>
    <name>A0AAN6P9U5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RTA1 like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_18809</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854482">
        <property type="protein sequence ID" value="KAK4034383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P9U5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF8">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14140)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="303"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4034383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="326" mass="35169" checksum="AFEA2F897CC3ECC8" modified="2024-10-02" version="1">MTTTNTVPAGWRPNYETCVEVSPYCPVKATTLGYFPNQGVNIFLALGYGLAALVTIAIGVWKRTWGYSIAVGAGCILECVGYIGRALLAVNPWNSGAFKMQIVAIILGPTLVCIGLYLTLKHAVNALNRSLSRVAPRVYPLFFVPADISCLVIQAIGGGIAASAGRDKLDLLQHGNRTIMAGIVLQVVVLGTFGALAGDYLFRAGRYFKSGAVAPEYQEGAALWVTKKFRAFVWAIGVAYATLLIRCIYRIAEMAGGWGNHIMQDEPSFVVLESFMVLIACVLLAVFAPGIFFPQMSHSFVAPEDEKRPQTESDSAGFEMERVSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P9U7</accession>
    <name>A0AAN6P9U7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">C8A01DRAFT_18760</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERT1/acuK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854480">
        <property type="protein sequence ID" value="KAK4034419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P9U7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050335">
        <property type="entry name" value="ERT1_acuK_gluconeogen_tf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056751">
        <property type="entry name" value="PAS_13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47659:SF1">
        <property type="entry name" value="TRANSCRIPTION ACTIVATOR OF GLUCONEOGENESIS ERT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47659">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24990">
        <property type="entry name" value="PAS_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="11">
        <location>
            <begin position="73"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="113"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="608"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="19"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="51"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="144"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK4034419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="686" mass="75119" checksum="BBED08C7877374EF" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P9V5</accession>
    <name>A0AAN6P9V5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_40072</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854528">
        <property type="protein sequence ID" value="KAK4033470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P9V5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042879770" evidence="3">
        <location>
            <begin position="19"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="193"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="259"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4033470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="277" mass="29627" checksum="57427F185B6D499D" modified="2024-10-02" version="1">MLLTTALLAAGVAGQILGKKPVFLYPADGSKYVYNKLDTVVVTYAAQDETAELYTFCDPGRETMIDHQTVPGFSASVPVLLNFTSEMPCWFDLRTGPNGIDGKNSVWFNVLSEERSTGPQTLGVDSNTPRSPTPPTLSTPSSRTTTRRNSRRAATTDNSSSSIAPTSTPTPDSNEIPTPAPEGGETAGGGMSYWVATGIGLGTGIGLAVLIGLGFMCWCRRIDRQHEKSKEALERFLEARRAEDFHRRHPWSRSEDSEQGGSPSASCPPGGQGAGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PA11</accession>
    <name>A0AAN6PA11_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_49151</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854478">
        <property type="protein sequence ID" value="KAK4034488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PA11"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF37">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4034488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="499" mass="56377" checksum="9DE821A9811F81B8" modified="2024-10-02" version="1">MYDGQEELDNLVWDKNDEDADKSLKKMRLKTTCREVERLAAQRFRTRATLVSLLIVGGFNILYRVHLAEDPPRPDVMVRLPCPSLVQFPGVKTLQEAATAKYIAENTQIPIPRHFFYGRDPTLGPFIILQHVENRGSMSARLTAPSDDPSATHALDPDMTDATLEDLWGKAASCLVQLSRLTFPRIGALVEVEGDGDGGRTGSPFSSSYAIAGRPITHNMTDMVRLANVPRAVLPSESRTYGTADEWYVALAEMHLAQLVFQHNDAVESADDCRNKFVARQVFRRLAKRGLLSCFGFAEDDWSAQASSSSRIISSPAPAGSGAFRLWGDDLRAGNMLLSEADDLVAVIDWEFPYAAPTQFVLEPPWWLLLDPAETWPAGIDDWTRVYEARLKTWLAAVERAEDSIPDGHPSDLPVPLSTYMRESWETGRFWLSYGARKSWAFDMAYWKFLDERLHLLTDRERAALEPFVERKMRESKDRIIVDWDPVEARKRLSEVLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PAR8</accession>
    <name>A0AAN6PAR8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">endo-polygalacturonase</fullName>
            <ecNumber evidence="3">3.2.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Pectinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">C8A01DRAFT_19657</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(1,4-alpha-D-galacturonosyl)n+m + H2O = (1,4-alpha-D-galacturonosyl)n + (1,4-alpha-D-galacturonosyl)m.</text>
            <dbReference type="EC" id="3.2.1.15"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.15" evidence="3"/>
    <dbReference type="EMBL" id="MU854534">
        <property type="protein sequence ID" value="KAK4033383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PAR8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000002">
        <property type="entry name" value="Endopolygalacturonase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050434">
        <property type="entry name" value="Glycosyl_hydrlase_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31884">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31884:SF1">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00502">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10 15" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 16" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042924971" description="endo-polygalacturonase" evidence="16">
        <location>
            <begin position="17"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="active site" evidence="14">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00083621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAK4033383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="363" mass="37288" checksum="CBD6653A5CFD1D4E" modified="2024-10-02" version="1">MVSAALVLSLGALAAANPLPALLGDRASCTFTDAASAIKNKKSCSTITLKDITVPAGTTLDLTGLNDGTHVVFSGTTTFGYQEWKGPLISVSGNNLLVEGASGHVIDTNGAKWWDTKGSNGGKTKPKFFYAHKMTNSNIKNLNVKNTPVQAFSINDASNLGVYDVTLDNSAGDSQGGHNTDAFDVGSSTGIYISGAIVKNQDDCLAINSGTNITFTGGHCSGGHGLSIGSVGGRDDNTVKTVRILNSSIADSQNGVRIKTVYGATGSVSDVKYQGITLSGITKYGVVIEQDYENGSPTGNPTAGVPITKLDLTGVTGTVESGATNIYVLCAKGACSDWTWSNVIVKGGKTSSKCSNVPSPAKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PBE5</accession>
    <name>A0AAN6PBE5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_38256</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854449">
        <property type="protein sequence ID" value="KAK4035296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PBE5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4035296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="348" mass="37514" checksum="0B2636D55379872E" modified="2024-10-02" version="1">MTTYLSRPSTDSTPPGYTPHEVELARLDSASPSTLSTPPPYDDEAPSSSPFHPTVHFQIQTPGKPWLSLPLPTRPEPIPIFSLHPEDSSFSTAAQATPHFTCIRPERSSGSCYLTTTTSPSSSSGTPAAVATTTYRFGPNRPPLVRLFSPHATPLSPTTLNQLLFSKEKDNDEQQEPDDAKAWDTFPITSLGLLTRAVSFHSSRLGGTFQWRYASRKERHAAALSQHLGCGEGGEISSLLILERVVRVATAQNIPGASTSTGGKEEIRTVVAYFLRGETYRTPGSSGSSAGNGGRLVMDLSLWEAGDVKMEREMAVAMVVATCLVMLKREVDRRRAAQIAVMAGAVGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PBG8</accession>
    <name>A0AAN6PBG8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Para-nitrophenol 4-monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_49223</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854482">
        <property type="protein sequence ID" value="KAK4034370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PBG8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051205">
        <property type="entry name" value="UbiH/COQ6_monooxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43876:SF18">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G09540)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43876">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS MONOOXYGENASE COQ6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="8"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4034370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="421" mass="47160" checksum="3E2FE41BAB821D40" modified="2024-10-02" version="1">MTDRPFSKVLIVGAGPSGLLLALLLSKHGIPVHILEAAPHLDQQPRAAHYGAPAIPEFIRAGIAEEIRARGMLLDTMCWRSSVDHSYIAGFDAGKVLRDVDVDGQGTDLRTHCLALQELDQLMLGEVTGRYGGVVDWEHRVVGVGQDDGGAWCEVEVGGGRGRKVVRGDYVVGCDGAGSAVRRALFGEEFPGFTWDAQIVATNTYYDFEGKFGWHDANFIIHPEHFFMAARITRDGLYRITYGETPGLSRDEYLARQPWKFETILPGRPKPDAYKMINFSPYRMHQRCAPKFRVGRVLLAADAAHLCNPWGGLGITGGFVDVGGLYDCLAGIWDGKADESILELYSEKRIEKWKTIINPISQENFRRVSDKDPATRFERDEFMQLLKKGETDEVFLKELLMSPMEVRYDFTQHYKDVAKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PCG8</accession>
    <name>A0AAN6PCG8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CVNH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_38573</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854460">
        <property type="protein sequence ID" value="KAK4034940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PCG8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.60.10">
        <property type="entry name" value="Cyanovirin-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011058">
        <property type="entry name" value="Cyanovirin-N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036673">
        <property type="entry name" value="Cyanovirin-N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42076:SF1">
        <property type="entry name" value="CYANOVIRIN-N DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42076">
        <property type="entry name" value="CYANOVIRIN-N HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08881">
        <property type="entry name" value="CVNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51322">
        <property type="entry name" value="Cyanovirin-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyanovirin-N" evidence="2">
        <location>
            <begin position="14"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4034940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="76" mass="8196" checksum="156A01EC3F245F6F" modified="2024-10-02" version="1">MISGTETALGHPSGGYLGWGGENFSLSAEDINFSVEGDDLVPILRVSLRNSDGELENPDVNLSERISNNDGSFYFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PCK6</accession>
    <name>A0AAN6PCK6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heterokaryon incompatibility protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_47966</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854430">
        <property type="protein sequence ID" value="KAK4038396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PCK6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF12">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="22"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4038396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="212" mass="23727" checksum="259F5E3A2B38E006" modified="2024-10-02" version="1">MRLVNVQDYSLVEVDGPGSNQYAILSHTWNGTGEVTLDDMRDLAAAQAKCEWPKVQQTCALARSQGIPFVWIDTCCIDKSSSAELTEAINSMFEWYKKAKTCYAYLSDLAESPTGGPESDRGRQQLHADLGACRWFTRGWTLQELIAPREVEFYDKSWTMRGTKAFLQSDVASITNINESVLSDSDKLSIIPVACKMSWAAKRHTTRVEDIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PCU2</accession>
    <name>A0AAN6PCU2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methanethiol oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_17392</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854426">
        <property type="protein sequence ID" value="KAK4038523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PCU2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042967397" description="Methanethiol oxidase" evidence="1">
        <location>
            <begin position="23"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4038523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="398" mass="42495" checksum="9880FC3DEFBE8A3E" modified="2024-10-02" version="1">MAPSIFQSLAVVLAFSAGTSLCQEPVTSLVSRRLTEYLLPVTTQTHELARVPGSNFLLVSQMSNSQLVKIELDPATEEPVAYQSFPMGQNNQSGLHGVWPSQQYPGMMWLSLQWENKLLLVDPGNQSLSTVPSIIKTIDIPEPGNGPHSIFEIGDRVWAGLKAASEQTGGYYVFSAHVDNTTDTVLYPCLNSPVFIQEEPTTRLIYVTQDTASSIMRINVTSGETAQLPIPPEVGNTPVGMTTAHGPLGGVWFALAGNATGGSGSFGHIGPTGELQFFRLEKPMLGSNAGLLHIADASSAEGGPALWLLSTTLLSTNSADALIRVTFDDAVMEITGEEYVSIPTQNAWAHRIVVLDATVMVSELNTFTLVQLAYKNTVAGQWLPAQAVTGSTEHGVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PCW1</accession>
    <name>A0AAN6PCW1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Heterokaryon incompatibility protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_17382</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854426">
        <property type="protein sequence ID" value="KAK4038553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PCW1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF8">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="310"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4038553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="775" mass="85521" checksum="A8895343D11112F5" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PD34</accession>
    <name>A0AAN6PD34_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_47761</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854422">
        <property type="protein sequence ID" value="KAK4038681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PD34"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006577">
        <property type="entry name" value="UAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050730">
        <property type="entry name" value="UBX_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322:SF1">
        <property type="entry name" value="FAS-ASSOCIATED FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322">
        <property type="entry name" value="FAS-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00594">
        <property type="entry name" value="UAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UAS" evidence="2">
        <location>
            <begin position="183"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4038681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="513" mass="57537" checksum="B85CC0FC82ADA788" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PDG8</accession>
    <name>A0AAN6PDG8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1996 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_18513</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854467">
        <property type="protein sequence ID" value="KAK4034748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PDG8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018535">
        <property type="entry name" value="DUF1996"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662:SF3">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11970)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09362">
        <property type="entry name" value="DUF1996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1996" evidence="1">
        <location>
            <begin position="33"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4034748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="341" mass="37516" checksum="C15F99561B20B2F6" modified="2024-10-02" version="1">MLSLGGLGLAVLASCRSNILKMSCSQLVVDRIDPLVNPGVLGSPHLHQLVGGNSLNATMDPADDRAELSTCTTCTFPDDFSNYWTAVMYFRARNGTYKRVKQTGAIFSETARGGGITVYYFPPRKDPTNIVAFKKGFRMRNGDPSARNATGASKYQGIDYTCLVRDDTRFTNHTASFPDHMCPVGILTTIYFPPCWDGVNLDSPDHYSHVSWPTEGDYDDGAPCPATHPVKIPQIVLEVQWDTREFNAPELWPDDGSQPFVWSFGDTTGYGHHGDYVFGWRGESLARAFSDDEGCLGQGNTLCTLNMQSIAQANQCMLEPSVEEDVDGWLERMPGGVEADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PDT0</accession>
    <name>A0AAN6PDT0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_48262</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854440">
        <property type="protein sequence ID" value="KAK4038085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PDT0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF168">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4038085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="450" mass="51199" checksum="274D4547BFC6B942" modified="2024-10-02" version="1">MAFFTSLPKNPIAWPSTGLILYILSLLHLAHVIQRVRGWYRLRHVPGPPLAGWTSLWLTKGFMNGAFFQNVPALEEKYGPLVRIGPNMVVCTDVDTMYRMMGVRSDYRKSQWYTIARISRVADHILTIIDPELRRERKKYIMPAYTGRDVNHFEEGTDRALAAWIDLIERKYLSTPRESFECVKQDRDAKGVLAVNDATVPVLMAISNYVAFWKLVRMWPFYLALPNDGDECGFGAIVGHASKIITERLNPNVKPHTTPKRDMLQSFIDHGLRGEALKQEVGIQFFAGSDTVSSLLYTTFLLLLTHPATYARLQSELDTAFAQGNITPSPSIRDAEAHALPYLQAVIREGLRLFPPLCAPPLFKEVPRGGDVVCGHALPGGTLVATGDQQWHGSRERAFWGEDADCFRPERWLELVRRYNWSLADPLNPPKIQNNGVWQVRDFWVRVEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PDV3</accession>
    <name>A0AAN6PDV3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_37955</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854439">
        <property type="protein sequence ID" value="KAK4038115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PDV3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00157">
        <property type="entry name" value="Rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4038115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="192" mass="21659" checksum="9B6515BB20ECD85E" modified="2024-10-02" version="1">MMEEHTITVLLLGDEKCGKSTFLSRISQGRQNLLGKTPITLLRDMDQPFVFEIRSRKGQYRFEFCDTSSPENWKLLRPDLVLLCYDISQRLSLINLQRVWIKEVRSVFPSSDVLPVLVLGLKRDLRSEDDPNGIIYPQEGYQAAQALRADKYIECSAVTGELMTEAFDDICSTALKTTTPDGGQSEGGCTIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PDW9</accession>
    <name>A0AAN6PDW9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Dihydroorotate dehydrogenase (fumarate)</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_47305</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854408">
        <property type="protein sequence ID" value="KAK4039167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PDW9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004152">
        <property type="term" value="F:dihydroorotate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035241">
        <property type="term" value="F:protein-arginine omega-N monomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006221">
        <property type="term" value="P:pyrimidine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18090">
        <property type="entry name" value="Arginine_MT_Sfm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04741">
        <property type="entry name" value="DHOD_1A_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.26.10">
        <property type="entry name" value="Dihydroorotate Dehydrogenase A, chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033886">
        <property type="entry name" value="DHOD_1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023359">
        <property type="entry name" value="Dihydro_DH_chainA_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005720">
        <property type="entry name" value="Dihydroorotate_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007364">
        <property type="entry name" value="SFM1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35517">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE SFM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35517:SF1">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE SFM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01180">
        <property type="entry name" value="DHO_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04252">
        <property type="entry name" value="SFM1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dihydroorotate dehydrogenase catalytic" evidence="5">
        <location>
            <begin position="270"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4039167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="555" mass="59319" checksum="0A6563167048B399" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PEA6</accession>
    <name>A0AAN6PEA6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_36732</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854404">
        <property type="protein sequence ID" value="KAK4039311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PEA6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4039311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="423" mass="46014" checksum="14CA1D6D8BA4B7D9" modified="2024-10-02" version="1">MNTSLVTRTTPRASPSPAAARTPRTSLPPPGITDLPVELLLHLQGFLTRGETNALAATCNGFSALFHPLLWRDDIATGTYDSAAWAVRGADGDSVEFLERVVEVYGADPRRWVRATGTRDLTSASLLGLAAWYGRSAQTRWLLARGADAVGIAGVVDSPLWEWRPRALDMVLLGRRSNSETGGCPAALFLALLEHGADGRVLLMWLGDMYRCDEHKNDCATPIIEWAVSMSGRSPMMAMAAINAGIDFVLDCVGRPVLALSILLDASTPPIPPWFHPVVKCVQAIIEKCNTEGWNSGLMDALEYLAPRINADPLERKAVPLAYQAITRSSINPDIRYQMLKLLLETTGVHPDVEEPCAEESALLIEVNRLVDAGSCPDLRCLEVLLRYGADPLRRYSRIEGGACSPLVLKSHIWVAKKGQLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PEJ7</accession>
    <name>A0AAN6PEJ7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_16534</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854399">
        <property type="protein sequence ID" value="KAK4039497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PEJ7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035194">
        <property type="term" value="P:regulatory ncRNA-mediated post-transcriptional gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF322">
        <property type="entry name" value="HELICASE MOV-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="2">
        <location>
            <begin position="364"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4039497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="622" mass="68644" checksum="8C96A2514E333D5F" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PEX0</accession>
    <name>A0AAN6PEX0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_47722</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854421">
        <property type="protein sequence ID" value="KAK4038700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PEX0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="227"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4038700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="292" mass="31453" checksum="B9BCA0F4820A819A" modified="2024-10-02" version="1">MASATASIPRFLLPQSGLIWRRAAAPSSASSGPSRIFLRLASTSKPNPPSGGPRVLAKPERFNPPSHGARLPKKGIPRHYGGDLSAAEVTAQTVREYPGMPPPKHTRAHWFLHNRWIHVVITVGTLTTLAIFTFTLSFKHTSPFADMLPPASDFLYHPISSTRMLIEVLRLHEAHKTARINDKRRRNVEDVAKRAAYRKAHGLPDEMGLFNQPMAKIRKDGGEGGDDASPVAAAAAASGEGQGAEAAGAGEGAAATPESEGKGNKGPEVRRLTEEERQAVVEKAKGKWMGIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PF07</accession>
    <name>A0AAN6PF07_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Glucanase</fullName>
            <ecNumber evidence="12">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">C8A01DRAFT_37203</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="12">Belongs to the glycosyl hydrolase family 6.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="12"/>
    <dbReference type="EMBL" id="MU854417">
        <property type="protein sequence ID" value="KAK4038878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PF07"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.40">
        <property type="entry name" value="1, 4-beta cellobiohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016288">
        <property type="entry name" value="Beta_cellobiohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036434">
        <property type="entry name" value="Beta_cellobiohydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001524">
        <property type="entry name" value="Glyco_hydro_6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34876">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34876:SF4">
        <property type="entry name" value="1,4-BETA-D-GLUCAN CELLOBIOHYDROLASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01341">
        <property type="entry name" value="Glyco_hydro_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001100">
        <property type="entry name" value="Beta_cellobiohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00733">
        <property type="entry name" value="GLHYDRLASE6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51989">
        <property type="entry name" value="Glycosyl hydrolases family 6, cellulases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00655">
        <property type="entry name" value="GLYCOSYL_HYDROL_F6_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00656">
        <property type="entry name" value="GLYCOSYL_HYDROL_F6_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 12" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 12 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042669456" description="Glucanase" evidence="12">
        <location>
            <begin position="18"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="14">
        <location>
            <begin position="26"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="69"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="69"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8 11">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="437"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="403"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="431"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="435"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001100-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001100-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK4038878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="482" mass="50608" checksum="066C4EB4C333D959" modified="2024-10-02" version="1">MVAKLLLSAALAATALAAPVIEERQNCGSVWSQCGGNDWKGATCCASGSTCVAQNQWYSQCLPGSQVTTPGVTSSSSSSTKSSSTSTGTSTSSRTASSTTTPPVVTSPSTTIPGGASVTASYSGNPFSGVQLWANDYYSSEVHTIAIPSMTGAMATKAAAVAKVPSFQWLDRNVTIDTLMAKTLSQIRAANKAGANPPYAAQLVVYDLPDRDCAAAASNGEWSIANGGAANYKGYIDRIRQMIIEYSDIRTLLVIEPDSLANMVTNTGVQKCSGAATTYKELTVYALKQLNLPNVAMYLDAGHAGWLGWPANIQPAADLFAGIYKDAGKPVAVRGLATNVANYNAWSVASAPPYTSPNPNYDEKHYVEAFSPLLTAAGFPAHFITDTGRSGKQPTGQTEWGHWCNAIGTGFGARPSANTGHDLLDAFVWVKPGGECDGTSDTTAARYDLNCGRPDALQPAPEAGQWFQAYFEQLLTNANPPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PF21</accession>
    <name>A0AAN6PF21_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_16318</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854393">
        <property type="protein sequence ID" value="KAK4039753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PF21"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4039753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="180" mass="18252" checksum="83FBD8E94E20D3E5" modified="2024-10-02" version="1">MSANPDSVGNQGEFHSRVPQAKPMTTSGHQLGQQPGNEAAPDFRAKTFPPGSAPAEHTHQPNPVDSTPGQALNPDATTQTGGRTGALEMPGATSGDVHAASTFARPVQGQTARGGKKERSGLEGVGATASTSDETVEGRVRALGADLPEGVERGVRGKGPGAEETNPASAGEVAAEKRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PG63</accession>
    <name>A0AAN6PG63_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">V-type proton ATPase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_15755</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments. This subunit is a non-integral membrane component of the membrane pore domain and is required for proper assembly of the V0 sector. Might be involved in the regulated assembly of V1 subunits onto the membrane sector or alternatively may prevent the passage of protons through V0 pores.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1).</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the V-ATPase V0D/AC39 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854379">
        <property type="protein sequence ID" value="KAK4040353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PG63"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1690.10:FF:000001">
        <property type="entry name" value="V-type proton ATPase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1690.10:FF:000003">
        <property type="entry name" value="V-type proton ATPase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.50">
        <property type="entry name" value="ATP synthase (C/AC39) subunit, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1690.10">
        <property type="entry name" value="V-type ATP synthase subunit C domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036079">
        <property type="entry name" value="ATPase_csu/dsu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002843">
        <property type="entry name" value="ATPase_V0-cplx_csu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016727">
        <property type="entry name" value="ATPase_V0-cplx_dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035067">
        <property type="entry name" value="V-type_ATPase_csu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044911">
        <property type="entry name" value="V-type_ATPase_csu/dsu_dom_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11028">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT AC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01992">
        <property type="entry name" value="vATP-synt_AC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018497">
        <property type="entry name" value="V-ATP_synth_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103486">
        <property type="entry name" value="V-type ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00059115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR018497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4040353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="365" mass="40797" checksum="266842A0D4300104" modified="2024-10-02" version="1">MEGLLFNVNNGYIEGIVRGYRNGLLTGNNYTNMTQCETIDDLKLQLGPAYGDFLGTLPPNPSTSSLASKTTDKLVSEFRYVRANAVGSLAKFMDYVTYGYMIDNVALLITGTLHERDTRELLERCHPLGWFETMPVLCVATNIEELYNSVLIETPLAPYFKGSLSHQDLDELNIEIVRNTLYKNYLEDFYDFVNSHPDMAGTPTAEVMSELLEFEADRRAINITLNSFGTELSKADRKKLYPSFGNLYPEGTLMLSRADDFDGVRLAVEGVADYKAFFEAAGLGGGPGGPGNMAGGSGSDGRSLEDMFYQKEMEIAKGAFTRQFTFAIVYAWVKLREQEIRNITWIAECIAQNQKERIGNYISVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PGA3</accession>
    <name>A0AAN6PGA3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">3-oxo-5-alpha-steroid 4-dehydrogenase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">C8A01DRAFT_35646</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the steroid 5-alpha reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854379">
        <property type="protein sequence ID" value="KAK4040316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PGA3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001104">
        <property type="entry name" value="3-oxo-5_a-steroid_4-DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039357">
        <property type="entry name" value="SRD5A/TECR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556:SF28">
        <property type="entry name" value="VERY-LONG-CHAIN ENOYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02544">
        <property type="entry name" value="Steroid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="259"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="3-oxo-5-alpha-steroid 4-dehydrogenase C-terminal" evidence="10">
        <location>
            <begin position="165"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK4040316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="316" mass="35453" checksum="683A2EDF3CFDDB80" modified="2024-10-02" version="1">MATTLSLKLSNRAPKKPIRKLPATVELPHDATVEDAKVLIARQAGFADYNRVGLFDPVSKQTLKNRRALVRDEAGVVSAGELVVKDLGPQVAWRTVFVIEYFGPILFHALVPLIRPYIYLIPPFAYKSEAETPMTQVQWLLFALFQLHFLKREYETVLVHKFSANTMPARNIVRNSAFYWLMAGLLCALDVYAPGNLSARDALVPLDYVGLALFAAGETCNWIVHQHLASLRKPGGTEKGIPHCIGSGLVTSPNYMFEVLAWVGVILISRSWAVVLFICTGIVYMRSWSRGKEKALRSEFGDRYKKKRYTMLPGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PGK7</accession>
    <name>A0AAN6PGK7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_36254</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854393">
        <property type="protein sequence ID" value="KAK4039718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PGK7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050888">
        <property type="entry name" value="ZnF_C2H2-type_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24406">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR CTCFL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="147"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="81"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="344"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="469"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
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            <end position="566"/>
        </location>
    </feature>
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            <begin position="82"/>
            <end position="108"/>
        </location>
    </feature>
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            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
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        </location>
    </feature>
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    </feature>
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            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        </source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK4039718.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="566" mass="63090" checksum="E5ACD3614C7570FE" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PGU2</accession>
    <name>A0AAN6PGU2_9PEZI</name>
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        <recommendedName>
            <fullName evidence="4">BTB domain transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_36287</name>
    </gene>
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        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Sordariomycetidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854393">
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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            <end position="113"/>
        </location>
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        </location>
    </feature>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4039750.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="390" mass="43049" checksum="A0BC1CC0FE7820D7" modified="2024-10-02" version="1">MTTTTRSAAKKQEQPSNAPLTEEAQLGSKHKTEESAGPPSPKRAKKEVGDEQKTAKQETDGHESHGKKLEHQEGQQNGTQKEHETKKPPKQQPSPKKPTTSAVQPHAHDDTPSNILEKGIIYFFFRTRVNASSAPSSITDIARSHILLRPIEPDAKLANNKPIGDAGNARLCLIPKKTLPRTGRDRWTAFVEKAGVSFAQLKDEFLASSEYETKTAGTRHAPAATPVGEGVYAITSTGRESHLVYVLTLPAELGEVQREIGLKERGSFVISTKNPEFPGPANARLPKAAEYPKELLEEFRSLRWVPTQPKHLDYVNTQFLLVGESSGTEKALQPQNEDQEQGKAEPAEEVERLEEEDAERMKGLSEDDSGRIFADLQVHAGDYPKLQTTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PGZ0</accession>
    <name>A0AAN6PGZ0_9PEZI</name>
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        <recommendedName>
            <fullName evidence="10">DUF829-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_15381</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="6">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854369">
        <property type="protein sequence ID" value="KAK4040809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PGZ0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008547">
        <property type="entry name" value="DUF829_TMEM53"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12265">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12265:SF30">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05705">
        <property type="entry name" value="DUF829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="144"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4040809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="369" mass="39355" checksum="4339F1320E1460D2" modified="2024-10-02" version="1">MGKQTSGFSLPGFVRLAPSIYVQDAQLGVGGYHAGHGPTYSDSSFYPPPDPAPKHSSRSRDTAPPDLIIITSWTGAVDKHVAKYTAAYNTLYPGVPILVITTVLSDFAIHSTKHKLKVLASAVDYLLSQEQPIIHPAHSLQSSTATLSPPYHHHQLPPPFSNSQLDSSAPTKPRFSSLLLHAFSEGGAHKAVLLARAYLSLSPTASRLPVEALILDSTPGTASYARATTAFARALPTHHAQPRLTKLLGTPLAAGVVGLVWAGLRGDEVVDWGDVHRHGVESAGLEKDGGSGGDGVEGEKMPVGSLMVRFKRTEHCAHAKGVVNGGVYWAAVRRTWEMRVDAGMGLRMGLGRRLSLDSLCFGGDEEGEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PGZ1</accession>
    <name>A0AAN6PGZ1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_47424</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854412">
        <property type="protein sequence ID" value="KAK4039031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PGZ1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17364">
        <property type="entry name" value="MFS_PhT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004738">
        <property type="entry name" value="Phos_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00887">
        <property type="entry name" value="2A0109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="235"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="370"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="407"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="433"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="506"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="50"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="565"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="565"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="577"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4039031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="586" mass="62954" checksum="B1B85068F4B67CFC" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PH06</accession>
    <name>A0AAN6PH06_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA polymerase II holoenzyme cyclin-like subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_46200</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family. Cyclin C subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854376">
        <property type="protein sequence ID" value="KAK4040482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PH06"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20513">
        <property type="entry name" value="CYCLIN_CCNC_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028758">
        <property type="entry name" value="Cyclin, C/H/G types"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0195">Cyclin</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="5">
        <location>
            <begin position="53"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
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            <begin position="260"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
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            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
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            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4040482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="359" mass="39181" checksum="E59F2AE39E0F8A4E" modified="2024-10-02" version="1">MAANYWESTQRKHWQFTKDDLAGLRQRLDDEDPGLVQMFPLPQLRHLNIYFNQQINRLGKRLGVRQQAMATAQVYLKRFYTRTAIRQTNPYLVITTALYLACKMEECPQHIRLLTQEARSLWPSDLHGHDAARVGECEFSLISEMHSQLIVHQPYRSLLAVQDDFALAHDEMSLAWMVVNDHYMTDLPLLHPPHVIALTAVLLALVLRPSGNAAAAGGGGGNAGTAAAAAAAGAGGVAMAATALAQAQAQAQARAAAMGAGGGAGTPGFGSQGSQQQMGFSQGNSQGEGAAAEPKKVTDPRLAKVQRFAAWLADSNIDVEAMVDCTQELISFYECHEQYNDKHTREQISRFIKARSLDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PH09</accession>
    <name>A0AAN6PH09_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_37679</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854431">
        <property type="protein sequence ID" value="KAK4038365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PH09"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4038365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="285" mass="29960" checksum="019C19E0510ACCDF" modified="2024-10-02" version="1">MPANVASADRQRDPPPAPSGPPLGYRDPPAPAASVTGPVPAAPKGGMKRASSGDDQEPAPQPKRPRTHVEQEPAPATIKEEEEEADLGSIPALPAAAAPAPSAHAPAAAAAPSQPAPNLRLRIRQGGELRVVRELHHSGRAAAGCPALPGPHANARVRIVARETGEFVFAGDVHVTPGELADVEAGAGGIFGGEEVKVEEESEEEEGAEVEVKEEDMEAEEDPAAAAAAPWSDQLSPPPWPAPPLKVFFNGWGRRIERSLPGRWQKVVFSLGDWHIVRWVPTTES</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PH77</accession>
    <name>A0AAN6PH77_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase</fullName>
            <ecNumber evidence="4 14">2.4.1.131</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">C8A01DRAFT_47356</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 14">GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. Catalyzes, on the cytoplasmic face of the endoplasmic reticulum, the addition of the fourth and fifth mannose residues to the dolichol-linked oligosaccharide chain, to produce Man(5)GlcNAc(2)-PP-dolichol core oligosaccharide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>an alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + 2 GDP-alpha-D-mannose = an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + 2 GDP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:29523"/>
            <dbReference type="Rhea" id="RHEA-COMP:19515"/>
            <dbReference type="Rhea" id="RHEA-COMP:19516"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:132511"/>
            <dbReference type="ChEBI" id="CHEBI:132515"/>
            <dbReference type="EC" id="2.4.1.131"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12 14">
            <dbReference type="Rhea" id="RHEA:29524"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.131" evidence="4 14"/>
    <dbReference type="EMBL" id="MU854409">
        <property type="protein sequence ID" value="KAK4039151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PH77"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004377">
        <property type="term" value="F:GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03806">
        <property type="entry name" value="GT4_ALG11-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000168">
        <property type="entry name" value="Alpha-1,2-mannosyltransferase (Alg11), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038013">
        <property type="entry name" value="ALG11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031814">
        <property type="entry name" value="ALG11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45919">
        <property type="entry name" value="GDP-MAN:MAN(3)GLCNAC(2)-PP-DOL ALPHA-1,2-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45919:SF1">
        <property type="entry name" value="GDP-MAN:MAN(3)GLCNAC(2)-PP-DOL ALPHA-1,2-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15924">
        <property type="entry name" value="ALG11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="30"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="ALG11 mannosyltransferase N-terminal" evidence="17">
        <location>
            <begin position="126"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="16">
        <location>
            <begin position="368"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00056799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF15924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAK4039151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="570" mass="63029" checksum="3329079A95C72508" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PH87</accession>
    <name>A0AAN6PH87_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_16062</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854386">
        <property type="protein sequence ID" value="KAK4040033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PH87"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF11">
        <property type="entry name" value="ZINC FINGER PROTEIN YPR022C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="41"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="71"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="92"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4040033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="872" mass="97908" checksum="8FE1EC423F5428F4" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PI59</accession>
    <name>A0AAN6PI59_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Coiled-coil domain-containing protein 16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_16424</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854396">
        <property type="protein sequence ID" value="KAK4039616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PI59"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033260">
        <property type="term" value="P:nuclear DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040050">
        <property type="entry name" value="ZNF830-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13278">
        <property type="entry name" value="ZINC FINGER PROTEIN 830"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13278:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN 830"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="65"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="344"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="94"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="166"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="207"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="346"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="361"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4039616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="380" mass="40560" checksum="9E1F7796D0252724" modified="2024-10-02" version="1">MADVRALLRQQRAARRIEHPHASYIDAGKLVCTVCSEHVKTESLWDGHLRSAGHRQRLQSLHQASKNGSNGYAGFVGQSAEVKGPSNKRKLSGSDEDTADHDDDASRRKRTKPDGPSPDHAQQEAGTPSKHNDSSRPGKPVTPPLARRTSGTPTAGVEMQMPSRPATPSTGGTPMATTPKAAPIGRSPLIPDEATASQQETIRGTRAGTQPAPSTTTATAAVPVDEDEWAAFEADLVHPTNAPNPAAAAVAALSSDAVISAPVMSAAEIAAKSEEEERARRRAQADIQIEDEKEEATRALENEFEVMEELEARARKLRERREALRVQSNGGGAAARGLIADGEGKGAAAAELGKENAAVQQEEEEDEDDEDDWDGFRFRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PIE0</accession>
    <name>A0AAN6PIE0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Oxidoreductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_14804</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854357">
        <property type="protein sequence ID" value="KAK4041441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PIE0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051317">
        <property type="entry name" value="Gfo/Idh/MocA_oxidoreduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055170">
        <property type="entry name" value="GFO_IDH_MocA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43708">
        <property type="entry name" value="CONSERVED EXPRESSED OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43708:SF5">
        <property type="entry name" value="CONSERVED EXPRESSED OXIDOREDUCTASE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22725">
        <property type="entry name" value="GFO_IDH_MocA_C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="3">
        <location>
            <begin position="4"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="GFO/IDH/MocA-like oxidoreductase" evidence="4">
        <location>
            <begin position="138"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4041441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="375" mass="41793" checksum="E59B42791A07104F" modified="2024-10-02" version="1">MAPIKVGIVGYGFSTKCFHLPFILPNPELEVYAFLQRAAPPSEPSQAPRWGHCTIDFPQAKHYRTADEFYADELIELVVVCTGTHEEFVEKALLAGKHVVVEKPFVNTSAEADRLIALAKAKGVILTVFHNRRFDSDFRTLHHLTSQGALGDVLEADIHFDYPDPGWISGWGKEYTPGQGMTFGLGTHTLDQALYLFGTPSSVTGFLRSNRGVDSEVDDTFTIMLQYSGKQKNLLVTVKTAVVTHMKDQLRFFVRGSKGTYLKFGTCPQESQAIAAPGQPATGPEIGVEDERIWGTLTTTSEFDPKTQKFDEESKKYIGKYPSLPGWYRGYYENVSAAIRGREEVFVKPETARDGLRIIELARESHEKGCTVAWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PIY4</accession>
    <name>A0AAN6PIY4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Palmitoyl-protein thioesterase 1</fullName>
            <ecNumber evidence="2">3.1.2.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Palmitoyl-protein hydrolase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">C8A01DRAFT_14666</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the palmitoyl-protein thioesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.22" evidence="2"/>
    <dbReference type="EMBL" id="MU854354">
        <property type="protein sequence ID" value="KAK4041612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PIY4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000107">
        <property type="entry name" value="Palmitoyl-protein thioesterase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002472">
        <property type="entry name" value="Palm_thioest"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11247:SF8">
        <property type="entry name" value="PALMITOYL-PROTEIN THIOESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11247">
        <property type="entry name" value="PALMITOYL-PROTEIN THIOESTERASE/DOLICHYLDIPHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02089">
        <property type="entry name" value="Palm_thioest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00414">
        <property type="entry name" value="PPTHIESTRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043017758" description="Palmitoyl-protein thioesterase 1" evidence="10">
        <location>
            <begin position="22"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="317"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK4041612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="331" mass="37034" checksum="3E0FE5465E02F47E" modified="2024-10-02" version="1">MAIVKHLKLLVVGSLIAAVIAKPVERRFEAGDEDDDTPLPLVIWHGLGDTYQADGMLRVAELADEVNPGTLVYSIRMDDNAARDRYASFVGNLTDQVAKVCADIAADPILSTAPAIDALGFSQGGQFLRAYVERCNKPPVRSLITFGSQHNGIAAFRDCTPTDWVCRIAMAVLSGDAWSGTVQSKLVPAQYYRNPEEYEQYLEHSNFLADINNEREEKNEAYKKNIAKLDNFVMYMFEDDTTVIPKETAWFEEVNGTESTPLRARKLYTEDWLGLRALDRKGGLKFRTAPGDHMQLSEELLKEAFGDFYGPLNPHRGRSEPRPGNRRGDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PJ22</accession>
    <name>A0AAN6PJ22_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Putative gamma-glutamylcyclotransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_14612</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the gamma-glutamylcyclotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854353">
        <property type="protein sequence ID" value="KAK4041672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PJ22"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045038">
        <property type="entry name" value="AIG2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009288">
        <property type="entry name" value="AIG2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036568">
        <property type="entry name" value="GGCT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31544">
        <property type="entry name" value="AIG2-LIKE PROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31544:SF2">
        <property type="entry name" value="AIG2-LIKE PROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06094">
        <property type="entry name" value="GGACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110857">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Gamma-glutamylcyclotransferase AIG2-like" evidence="4">
        <location>
            <begin position="17"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4041672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="181" mass="20556" checksum="8ABB14CF21B3CF0D" modified="2024-10-02" version="1">MAVQNSVQSDDGTRCAFFYGTLMVPDVFYSVCYGAQDVPASIAKLHTFLPAILHGYCRRRVKYADYPGIIPDKDHDVFGTFATGLTKANMAKLDYFEGGQYVRKTVTVKLLDKVGNLKGEGNVEGAERTAEVYVYLDKRELEDKEWDLEEFRRDKMRHWTRAGYVFEDCDPNNPAKVDGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PK45</accession>
    <name>A0AAN6PK45_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_35369</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854373">
        <property type="protein sequence ID" value="KAK4040606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PK45"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="65"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4040606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="313" mass="35003" checksum="54E4BC6884845654" modified="2024-10-02" version="1">MSVVDAIGLWFHHAARWARSWYSTEPLAVELLPRTYNETKLLNDTVTEVLITCGGDKSQGLKLQYKQQPEAGSEYVSVVSSLWAYTREDLLRVRFPPYHGNSGTPAKDLSEITDREELHGVFTGEVLDQELHNLQLLDGSVAGIVQLVAAVVSTNPYQTAALGAGSDSVVLRGLLLEYHPNGTLQDALDAAKTETDWHWCQWGLQITKALAHLHQCGLTHMDLKPSNVVISADMRAILVDLSGIGGVTREWLSPEMRITAISSHRASRLESKTIFGHWAKCYQRWRMLVATRRGSYWGASPRLQLKLSHRVFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PKM7</accession>
    <name>A0AAN6PKM7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_44238</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854336">
        <property type="protein sequence ID" value="KAK4042744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PKM7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14705">
        <property type="entry name" value="bZIP_Zip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000075">
        <property type="entry name" value="BZIP transcription factor (MetR)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13044">
        <property type="entry name" value="ACTIVATING TRANSCRIPTION FACTOR ATF 4/5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13044:SF14">
        <property type="entry name" value="CRYPTOCEPHAL, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="8">
        <location>
            <begin position="194"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="51"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="122"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="208"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4042744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="286" mass="31352" checksum="FE75A864AACE253F" modified="2024-10-02" version="1">MASYGTGRVNVSQYLRNLNVQGPSVEETFTDEDLEKDLALFTNTQFFDFETGQHTDYQAPPTKPETTRSPTDDVTPTESIMGDFPAGYEFPIPGDFSFGDYGSNFTSPTGPAFPDALGNLQPIQPSPQTAYPAPVPHQQQHHHQPAGYVPGGAGPSGGVEKRRAESISGHGHTAHVPNGRVLNFEDASRVAAEEDKRKRNTAASARFRIKKKQREQALEKSAKEMQEKVTMLEGRISALETENKWLKGLVTEKHGGRDDILDKLLKEVASQGDSISVGEAKSRKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PKW0</accession>
    <name>A0AAN6PKW0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_13605</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854335">
        <property type="protein sequence ID" value="KAK4042864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PKW0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4042864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="301" mass="33388" checksum="0902694FCB115128" modified="2024-10-02" version="1">MAQHSNLPDELIGAIVQRLCLSCTPREEDPSCSCEDTNQRDRGRVAALAALCQTSRQLNSLATVHLYHHPLCTRRAAVLAQTLVARKDLARHVKHLCLGDTFWDALSRRAEARNVQVDTVTSLCPNLESLHATLDYHEALQYMEETGSITTLPQLGVDWTTTLSLLRAAPNLTTLTLTLISACSDLSDLGGGGDKTLPNLTTLAFQFSTLSAASLITALRACPNLETFKYHMGGPLVGAEQFALPEAEHALLAHAPKLKFVRLHPNWGPQRPMFEDEWRFADRDQLERALARRGVKFEWRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PL27</accession>
    <name>A0AAN6PL27_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Calreticulin family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">C8A01DRAFT_44075</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the calreticulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854333">
        <property type="protein sequence ID" value="KAK4043008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PL27"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.250.10:FF:000001">
        <property type="entry name" value="Calnexin homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000011">
        <property type="entry name" value="Probable calnexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.250.10">
        <property type="entry name" value="Calreticulin/calnexin, P domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001580">
        <property type="entry name" value="Calret/calnex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018124">
        <property type="entry name" value="Calret/calnex_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009033">
        <property type="entry name" value="Calreticulin/calnexin_P_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11073:SF1">
        <property type="entry name" value="CALNEXIN 14D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11073">
        <property type="entry name" value="CALRETICULIN AND CALNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00262">
        <property type="entry name" value="Calreticulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00626">
        <property type="entry name" value="CALRETICULIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63887">
        <property type="entry name" value="P-domain of calnexin/calreticulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00803">
        <property type="entry name" value="CALRETICULIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00804">
        <property type="entry name" value="CALRETICULIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00805">
        <property type="entry name" value="CALRETICULIN_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042667986" evidence="9">
        <location>
            <begin position="22"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="502"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="250"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="545"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="258"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="148"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601580-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK4043008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="572" mass="63270" checksum="C3E16509AB5CDA1E" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PLF4</accession>
    <name>A0AAN6PLF4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_14161</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854344">
        <property type="protein sequence ID" value="KAK4042210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PLF4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042904350" evidence="3">
        <location>
            <begin position="24"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="304"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="471"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="508"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="538"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="591"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4042210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="656" mass="73256" checksum="2611278E4C24CDDD" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PLL3</accession>
    <name>A0AAN6PLL3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_43773</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the INSIG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854329">
        <property type="protein sequence ID" value="KAK4043284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PLL3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025929">
        <property type="entry name" value="INSIG_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051959">
        <property type="entry name" value="PAK1-Kinase_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44675:SF1">
        <property type="entry name" value="P21-ACTIVATED PROTEIN KINASE-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44675">
        <property type="entry name" value="PAK1 INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07281">
        <property type="entry name" value="INSIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0853">WD repeat</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="581"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="630"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="725"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="752"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="828"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="423"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="481"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="482"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="560"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4043284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="865" mass="92026" checksum="A234E52739C3242E" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PM77</accession>
    <name>A0AAN6PM77_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_14797</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854357">
        <property type="protein sequence ID" value="KAK4041416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PM77"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="432"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4041416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="476" mass="53160" checksum="D7491545C866301E" modified="2024-10-02" version="1">MSERPPEGLDDPPPAYSRLTTPRPPPPVETPELASGQPNQLSPWDFRALSDDDDDDDDDDDDPPQHAPIQPDIPLLLNDPDAFEHLNVVDYLSNPFANQEGPGKHIIVRGVSSSLWLLDCHHKVFPAYWKCMSCPPHNCFDRWDIVAMEEQAPNYLPVCSRPNCGAPANSQSVLVNTQKESIMTLGGKNLMASRVEEPLMWCCKCTGFRSESERQYPDCTHCVNFKESTCRDCARCNKFIEPTNHCNGDIVLFGVVHLHATALAVAEGREAWEAPDAFLSRALLYARHRLDDPVRAWWEVANSSIMFGQTFYGIIALQPAPQQNHSVVAPAQPTLTRPSEAPESVRPPPEERYLGEPRVPQRRPSTASLVGSPSQRVRGSLYNRRSRDSISPEPRLDDAIISIFNRRHPLTRRPSSRRPSSLEFLGSRTPDYRTAVLPSPAEPQSDDGTEGIIMALWPHSPNHSSPAQGFDRASTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PM95</accession>
    <name>A0AAN6PM95_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Squalene monooxygenase</fullName>
            <ecNumber evidence="16">1.14.14.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">C8A01DRAFT_13117</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>squalene + reduced [NADPH--hemoprotein reductase] + O2 = (S)-2,3-epoxysqualene + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25282"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15440"/>
            <dbReference type="ChEBI" id="CHEBI:15441"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="1.14.14.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="15">Steroid metabolism; ergosterol biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 16">Endoplasmic reticulum membrane</location>
            <topology evidence="3 16">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the squalene monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.17" evidence="16"/>
    <dbReference type="EMBL" id="MU854328">
        <property type="protein sequence ID" value="KAK4043377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PM95"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004506">
        <property type="term" value="F:squalene monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000166">
        <property type="entry name" value="Squalene monooxygenase Erg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013698">
        <property type="entry name" value="Squalene_epoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040125">
        <property type="entry name" value="Squalene_monox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10835">
        <property type="entry name" value="SQUALENE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10835:SF0">
        <property type="entry name" value="SQUALENE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08491">
        <property type="entry name" value="SE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 16" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 16" id="KW-0274">FAD</keyword>
    <keyword evidence="5 16" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0492">Microsome</keyword>
    <keyword evidence="12 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="14" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="455"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="485"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="17">
        <location>
            <begin position="23"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="Squalene epoxidase" evidence="18">
        <location>
            <begin position="210"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU367121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF08491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAK4043377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="514" mass="55684" checksum="951B24B0B7139FC6" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PMS7</accession>
    <name>A0AAN6PMS7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Asx homology domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_32982</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854334">
        <property type="protein sequence ID" value="KAK4042885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PMS7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028020">
        <property type="entry name" value="ASX_DEUBAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044867">
        <property type="entry name" value="DEUBAD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13919">
        <property type="entry name" value="ASXH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51916">
        <property type="entry name" value="DEUBAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DEUBAD" evidence="9">
        <location>
            <begin position="124"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="232"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="61"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="232"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="272"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="296"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4042885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="335" mass="36621" checksum="08E086C41619FAC6" modified="2024-10-02" version="1">MADEVPSSPLSSPPESVVNVVLGSPAKSESKLPAASSDRQEPTVEAAVEVTAKQPSPSPDGKVEAQEKPIAHDSDEGGQSSTQKRKASISRKSAPAKKVRRVLSAPRKSAQDKKWEAPFVYTDSKSPLANADLRAILLHPEAWDILTPEERRDVLAKFPDETHVLDAGTQDARPNPVSLRNDDNFRHDCARYCENIELGRHDEEWLSQAWVAHEKHKRGDYDQFLREQFEEDWDTKLPAESKTGDAETDDESKQGESPASKGTSRRSTRSPQGREGREGREGRNAATKGSLRTEVTVGNSETPQPTGSSGIRPSNPSATSQAQEAARSTVVVRSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PNW6</accession>
    <name>A0AAN6PNW6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_31276</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854318">
        <property type="protein sequence ID" value="KAK4044493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PNW6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042891246" evidence="3">
        <location>
            <begin position="20"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4044493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="405" mass="44892" checksum="0E97CC451D93A919" modified="2024-10-02" version="1">MLSTFALVALADLIFLAVGTEMSAADATVFEVMSELITELEQEPLVGNVFIAALVYAAASSLAHLFVFFRGCLPVVAAKVNQTLVCLSAGATRRATLAREAVINAAWGFINALRSSTVAGILFWVLSRLVLPPLLLVLRPFIPAILRKYFLWRNWVEARLWDFADIVCVDMGRRSERRRVLKARELQFGVQMSKLTKLNDDVARLARVAADVWRESRDWLNGEFEHLRPTEFAGRVVIAVPEEGPVPTLGLWFRLRYRVDLEVFLVNQTIGRFDSAMERNQVSITGLEHQVAMWSSQIRAIDDQVEICRQRKRAALIRANFARPTQIASVACGLPRLGRHSPLFPLSPLSPSLPSPPPRRAILPPPAPSPTPEEVLTAAAAATPLPKGRKAALLAQARECLEHTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PP35</accession>
    <name>A0AAN6PP35_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">C8A01DRAFT_13690</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the Tom70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854337">
        <property type="protein sequence ID" value="KAK4042674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PP35"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030943">
        <property type="term" value="F:mitochondrion targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005687">
        <property type="entry name" value="Tom70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00990">
        <property type="entry name" value="3a0801s09"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46208">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46208:SF1">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 10" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="2 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="339"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="407"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="475"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="550"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="65"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="99"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK4042674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="622" mass="69061" checksum="3717E2B0EA321987" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PP75</accession>
    <name>A0AAN6PP75_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">C8A01DRAFT_44873</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">ATP-dependent RNA helicase involved spliceosome assembly and in nuclear splicing. Catalyzes an ATP-dependent conformational change of U2 snRNP. Bridges U1 and U2 snRNPs and enables stable U2 snRNP association with intron RNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the DEAD box helicase family. DDX46/PRP5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="MU854346">
        <property type="protein sequence ID" value="KAK4042100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PP75"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17953">
        <property type="entry name" value="DEADc_DDX46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22474">
        <property type="entry name" value="KH-I_PRP5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000008">
        <property type="entry name" value="ATP-dependent RNA helicase RhlB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000079">
        <property type="entry name" value="probable ATP-dependent RNA helicase DDX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056149">
        <property type="entry name" value="PRP5/DDX46/KHDC4_KH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23469">
        <property type="entry name" value="KH_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="17">
        <location>
            <begin position="418"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="449"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="654"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="246"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="815"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="13">
        <location>
            <begin position="418"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="42"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="58"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="106"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="246"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="824"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="847"/>
            <end position="859"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAK4042100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1057" mass="113737" checksum="801A2B24521E70F1" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PPA1</accession>
    <name>A0AAN6PPA1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Actin-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_44259</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854336">
        <property type="protein sequence ID" value="KAK4042764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PPA1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="280"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="428"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="280"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4042764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="583" mass="63427" checksum="AA86AF7F8E70091E" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PQK3</accession>
    <name>A0AAN6PQK3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_31439</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854319">
        <property type="protein sequence ID" value="KAK4044385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PQK3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="59"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="265"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="277"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4044385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="331" mass="36064" checksum="B3DA93FB122AC59C" modified="2024-10-02" version="1">MATPDAADGSRRQDSVIAASAAMLSLSTVTVVLRFHTRHILLGILGADDWMILAALEEWYTFLLYATSLSCCKISILLLYRRFLLIGWSRICTNIVAVIVAACSIWVIITSFIDCIPLEAVWDKGIQGRCLSLNVKMGNSYSHVVTDFIIFFLPIPFVARLTLGRRQKIGLVLVFCVGFVACLMSVIRIATLHSMDLVADGTYELAPLAIWSAVEVNLAIICACLTTLKPLVVRVFPRLLQSAAGYTATSSGTLDYHGERRMGTAGASLPRTHHHSSGSSSRPGGESAVSVKLDNARSDGSMTDEWEMEDLESVQRGVYLATPPKAYARSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PQW5</accession>
    <name>A0AAN6PQW5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_12331</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854320">
        <property type="protein sequence ID" value="KAK4044323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PQW5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF5">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="2">
        <location>
            <begin position="83"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4044323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="384" mass="43998" checksum="9C16417D7FFCD0C4" modified="2024-10-02" version="1" fragment="single">MLTLGHELTELLRAQRPIASEVDSKLSRLVDEFQVTQKQLRILQSLRYDSMRLREGEVASAHEQTFEWMFDRAASTSPHESRTGFSTWLEAEDGIFWVTGKPGCGKSTLMKFVSHHDTTTRSLQVWAAGKRLVTACFYFWRGAGENLQTKQDGLLRTLLSQIMTECPSLMPKLCPERWANVQQQTEPWTRQELLAAFSKLPEEKLSLNSAFAFFIDGLDEYDGSHEEIAQVVSQLAAPANVKICIASRDLPTFDHHFGSSAKHERRRKLILHEHTKADIMRFVQDKLGGDQRYRDFMCRQQHELGHDTLVNEITSRAQGMFIWVRIACEEVVKGLTHQDTPDILAARLETVPTDLEILYTRIIERVDPIYQRMSARILLLLLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PR14</accession>
    <name>A0AAN6PR14_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_12244</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854319">
        <property type="protein sequence ID" value="KAK4044383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PR14"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4044383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="178" mass="18709" checksum="E4B0B7FC472EF046" modified="2024-10-02" version="1" fragment="single">WMLDGELQDNASCRRLWAEEAGEEDLVLGQTGLSRSGHLTESLCSGPIPKRGTAGVCRPVCLEHLGSTVCAFSRAVIVSEQRRACEGAETWLTAVPESNVGATSGPGACCPTTLRTLPDVIAQISGFKRQWLALAAGLGNCSSAWVPPTAELWSEGIPSEEIPVLVAVADNHRALTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PR42</accession>
    <name>A0AAN6PR42_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RNA-binding S4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_13063</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854328">
        <property type="protein sequence ID" value="KAK4043426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PR42"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_uS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018079">
        <property type="entry name" value="Ribosomal_uS4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="30S 40S RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF4">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US4M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00632">
        <property type="entry name" value="RIBOSOMAL_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="RNA-binding S4" evidence="8">
        <location>
            <begin position="134"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="90"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="192"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="100"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="213"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4043426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="462" mass="52316" checksum="F0F45379140666E3" modified="2024-10-02" version="1">MRQRRLLRFHGLKRPRVRQTWNKYNLFNLTRLRTPLLQNKTFFQQKWIAKSMTRGYHGEHIKEYQWERMFSRRLLSAVNMDPAYMAQYDGSEQASGRGSGQKRRPGTKNHGPRNKGNINGPTPYMQMIFAPMERRLDVAIFRALFASSARQARQFVLHGAVTVNGKKMTYPGYLLNPGDMFQVNIERVMAATGRPKMPNKNQKALPPSSEATEAAEGEEGEAAEGEATEAAEGAAEPVDADAAKENHRAALKGLKDRARKIMLMKNVHMRAKQKQSLRKFLQEVKTNMDRTRKASDPSKAEMDDVERELTALLSDLSLTPAQLKAEAKKAYIERNKKRDRQLAAAAADTNADASTTTKTIRAGAAAASLGLLTESQQSVLKWMMQREAENPHDASKPYATPWKPREWMSPFAFIPRYLEVNQRVCAAVYLRHPVARPGKSEVPSPFSPTLSQLAFNWYLRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PSG3</accession>
    <name>A0AAN6PSG3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADH:flavin oxidoreductase/NADH oxidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_31668</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854321">
        <property type="protein sequence ID" value="KAK4044071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PSG3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02933">
        <property type="entry name" value="OYE_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000138">
        <property type="entry name" value="NADPH dehydrogenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="NADH OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893:SF91">
        <property type="entry name" value="NADPH DEHYDROGENASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="2">
        <location>
            <begin position="10"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4044071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="383" mass="41685" checksum="C4456876E922DE08" modified="2024-10-02" version="1">MASPSSSTRLFHPLPLTPSITLTHRLAMAPLTRYRSSDAHVPLVPLMATYYAQRASSLPGTLLVTEATFISPSAGGYANVPGIYNQSQIDAWRHVTDAVHAAGGYIFCQLWSLGRTAHADVAEKEGFVVHSSSAVPLPEEGTPVPVPVEMSVEEIRVRVGEYAAAARNAVEAGFDGVEIHGANGYLVDQFIQDTCNRRTDEYGGSVENRSRFAVEVVQAVVEAVGAERTAIRLSPWGRFQGMRMADPVPQFEDVISKIKGFGLAYLHLVQTKVPGSADAPVAGGDDSLDFALRLWDGPVLIAGGLTPKDARYLVDEEFKDKDVIATFGRHFISTPDLPFRIKEGIELNPYDRSTFYLPQSPVGYIDQPFSKEFEALHGPQALN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SKE7</accession>
    <name>A0AAN6SKE7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_21187</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854743">
        <property type="protein sequence ID" value="KAK4031631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SKE7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF5">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="3">
        <location>
            <begin position="51"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="383"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="386"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="400"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4031631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="411" mass="46140" checksum="FAAC93B8718A3873" modified="2024-10-02" version="1" fragment="single">LLEVLPASGLELNRANTARFSVAAEPDTVESLNFAQIDARKTTIQTAHAKTCRWFVQHPAYRNWLDPRMQSQNHGFLWMRSKAGAGKSTMMKFVYLESKKKAKSNTLTASFFFNARGDYLERSIIGMYRSLLMQLLKKFRDLQSILNDTDIVPSGQQGCPDLDALKALFRSAVIALERRSFTCFIDALDECDKQEVRDMVQFFEDLAADATEAGIQLRICFSSRPYPYISIHKGISLTLEDKSRHTEDLAQYVKSKLTIEDPRLLADLQSEILGKASGIFLWIVLTVDILNKEDDDGGLALRTKLSTIPDKLGDLFKSILMRDQKSPERLLLCVLWILCAKRPLTPAEFRHALWVALLDHKSEHGDCQVDSDVPDVQNVNACIPTSPGPSPLPLTPKSPPAAYKSSPSSQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SKY7</accession>
    <name>A0AAN6SKY7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_21548</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854998">
        <property type="protein sequence ID" value="KAK4031198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SKY7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4031198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="56" mass="6273" checksum="CC295B0D946C0507" modified="2024-10-02" version="1" fragment="single">CLVIRGICDYADSHKNDRWQRYASATAAAFGKKLLSYVPVSDLQKTRRAAELLQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SL47</accession>
    <name>A0AAN6SL47_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_20519</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854613">
        <property type="protein sequence ID" value="KAK4032411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SL47"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
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        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033932">
        <property type="entry name" value="YtcJ-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22642:SF20">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22642">
        <property type="entry name" value="IMIDAZOLONEPROPIONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase 3" evidence="1">
        <location>
            <begin position="66"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4032411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="554" mass="59792" checksum="238059C9EA869754" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SLC0</accession>
    <name>A0AAN6SLC0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_41674</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854684">
        <property type="protein sequence ID" value="KAK4031889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SLC0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="42"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="140"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="267"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="407"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4031889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="659" mass="72951" checksum="7F08E71DDF4B0238" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SLI4</accession>
    <name>A0AAN6SLI4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fungal-specific transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_42042</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854779">
        <property type="protein sequence ID" value="KAK4031515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SLI4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UbiX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43374">
        <property type="entry name" value="FLAVIN PRENYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43374:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="3">
        <location>
            <begin position="269"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="53"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4031515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="538" mass="60123" checksum="8120468029F1A925" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SLL5</accession>
    <name>A0AAN6SLL5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">3-carboxymuconate cyclase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_41718</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854692">
        <property type="protein sequence ID" value="KAK4031842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SLL5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75011">
        <property type="entry name" value="3-carboxy-cis,cis-mucoante lactonizing enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042855458" description="3-carboxymuconate cyclase" evidence="1">
        <location>
            <begin position="24"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4031842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="418" mass="41780" checksum="F386BAB89A87E158" modified="2024-10-02" version="1">MSFILRHLLLLPAFLSLIPEVISRPTSGCQQPGGNAAAAAGRAIYFITNDEANAVVALPIGSDGSISPGTVTQTGGAGSVALNSDSQPATPDALVSQSSLTIAGNAIFAVNAGSNTLSMLAISASDPTQLSLVGEPVAIPGEFANTVAASLKNRIVCVGTSGALAGISCSSFSARGLCPMDDLRPFDLGQTTPPVGPTNTVSQTFFSADESMLFTTVKGDPPTNKTGFFSAFPVQRAGAGSRAGIRSKAAVSSIEQRSTPEGTAVLFGSQVIHGTSNVFATDAAFGAAILSVDPVSGQATTIATGEVQGQVATCWVTVSPATGTAFVTDVGANRLVEMSIQDASVLSELDLSANGNPGLIDLRAAGNFIYALSPGNGTTEAAVTVVDVSGGSGSATMVQNFGLSGVAGQNAMGMAVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SLU1</accession>
    <name>A0AAN6SLU1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_41502</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854655">
        <property type="protein sequence ID" value="KAK4032067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SLU1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039514">
        <property type="entry name" value="6GAL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039743">
        <property type="entry name" value="6GAL/EXGAL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42767">
        <property type="entry name" value="ENDO-BETA-1,6-GALACTANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42767:SF1">
        <property type="entry name" value="ENDO-BETA-1,6-GALACTANASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14587">
        <property type="entry name" value="Glyco_hydr_30_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042935527" evidence="1">
        <location>
            <begin position="22"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="Endo-beta-1,6-galactanase-like" evidence="2">
        <location>
            <begin position="23"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4032067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="480" mass="52748" checksum="31D5DEA9FF7C6FD0" modified="2024-10-02" version="1">MIPPSLHQLALVLLAAPLASADVTTVINAKSNWGTWEGWGTSLAWWAKQFGNRDDLADTFFTLKSTKVNSQTLPGLGFNIVRYNAGASSSKAIGTERMVVSPNIKESRQIDGYWVNWDSEDPASASWDWSVDGNQRSALQKAIARGADRTELFSNSPMWWMCKNHNPSGAEDGSENIQSWNLEKHAIYMATVAKAFKDKWGISFSTVDPFNEPTANWWKAGGTQEGCHIDVATQGTIVNHLASHLSSRGLSTVITASDESYYDQALKTLQTIGSGPLSKINRIHVHGYQYASGNRAGLRDAAAAAGKKVWNSEYGDGVGSGENMARYLLKDMRELRPTAWVYWQVLDGGGWGLIDADNDANRLGNAEQKYFVLAQFARHIRPGMRILDAGRDNVVAAYDAGASKLVIVAVNWDAAQYINFDLSGFSQRPASGANVTRWSTQIGSGDRYVQHDDTTISGTKFWSQFDKNTVQTFEVTGIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SLU2</accession>
    <name>A0AAN6SLU2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_19869</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854549">
        <property type="protein sequence ID" value="KAK4033146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SLU2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4033146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="364" mass="39482" checksum="7CCC20DA063DE1F3" modified="2024-10-02" version="1" fragment="single">GPAAPSTGTVSRSSCATAPPPPTTRWTACGRRVSGAACPGSGRGGLRGVDGLPQVVLGAILEALPRSGCFWRCVAALNLARRLSVAPSQPLRIVQLGRVVAWERGTVPQLAADDSVETLPPFVRLTIDNDGLSKVERLAERPLFSRQRFDDRAFVVEREDWFGVTLAQFKDPQDPGFAVWDTPTPPDLAQCPVPLERLDSGRRFHTIDLAAVTGITFFFLHTKMSAIHAHSPSQPCAMPTYKALQEIRELDKYCTWVYVPLPRGDTRALGQCRLHVAAERTYARPRSVAFAKSGAEGGSNGVKVCFDGPGSCLRDGEKWSHYAMAGTLEFWFTGWSADISMRGGTLMPDEEGGEKMLGQLADSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SLW0</accession>
    <name>A0AAN6SLW0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MT-A70-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_41101</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MT-A70-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854609">
        <property type="protein sequence ID" value="KAK4032444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SLW0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007757">
        <property type="entry name" value="MT-A70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12829:SF4">
        <property type="entry name" value="N(6)-ADENINE-SPECIFIC METHYLTRANSFERASE METTL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12829">
        <property type="entry name" value="N6-ADENOSINE-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05063">
        <property type="entry name" value="MT-A70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51143">
        <property type="entry name" value="MT_A70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="213"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="218"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="235"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4032444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="244" mass="26311" checksum="94BAAF2570F37285" modified="2024-10-02" version="1" fragment="single">SPITPTHLPALLAATTPPKFNLIILDPPWPNRSAKRKRTGAGSYHPAPDLSSIHALLSHIPVASRLAPGGLVAVWVTNAARFAELLTGTVFPREWGVELVGEWTWVKVTTAGEPVVGVGSAWRRPWERLLIGRRKGGLPGGGRLGQVKGKVIVSVPDVHSRKPNLRGLFEEEMALVPGRYEALEVFARNLTAGWWAWGDEVLLFQRRECWVEGGEGEGEGKGEGEGKGEGRGEGEGEVEGEVGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SM85</accession>
    <name>A0AAN6SM85_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_20426</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854603">
        <property type="protein sequence ID" value="KAK4032502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SM85"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4032502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="57" mass="6165" checksum="20872F5FC976A2B2" modified="2024-10-02" version="1" fragment="single">FKYIEHYLDADTSFPKLLPKGIVTATNPTPTIGTEVSSTELSSLSTAGKDELVYFVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SMQ0</accession>
    <name>A0AAN6SMQ0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase</fullName>
            <ecNumber evidence="3 14">2.4.1.258</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Dol-P-Man-dependent alpha(1-3)-mannosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">C8A01DRAFT_40552</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 14">Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the first dolichyl beta-D-mannosyl phosphate derived mannose in an alpha-1,3 linkage to Man(5)GlcNAc(2)-PP-dolichol to produce Man(6)GlcNAc(2)-PP-dolichol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate = an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29527"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="Rhea" id="RHEA-COMP:19516"/>
            <dbReference type="Rhea" id="RHEA-COMP:19517"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:132515"/>
            <dbReference type="ChEBI" id="CHEBI:132516"/>
            <dbReference type="EC" id="2.4.1.258"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12 14">
            <dbReference type="Rhea" id="RHEA:29528"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the glycosyltransferase ALG3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.258" evidence="3 14"/>
    <dbReference type="EMBL" id="MU854559">
        <property type="protein sequence ID" value="KAK4032997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SMQ0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052925">
        <property type="term" value="F:dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007873">
        <property type="entry name" value="Glycosyltransferase_ALG3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12646:SF0">
        <property type="entry name" value="DOL-P-MAN:MAN(5)GLCNAC(2)-PP-DOL ALPHA-1,3-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12646">
        <property type="entry name" value="NOT56 - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05208">
        <property type="entry name" value="ALG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="184"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="330"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="394"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00093457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU364047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK4032997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="432" mass="48092" checksum="AB6013593A9CD6F4" modified="2024-10-02" version="1">MADQNPPIHLRVARFAFDILNGRHALSKLIPPLLFLADALLCALIIWKVPYTEIDWTAYMEQISQIVSGERDYTHIRGGTGPLVYPAAHVYIYTGLYHLTGEGADILLAQQLFAGVYMAALAVVMACYWQAKVPPYVFPLLILSKRLHSIFVLRCFNDCFAALFLWLAIFFLQRRSWMAGAVMYTLGLGVKMSLLLVLPAVGIVLLLGAGFATSLQLAAMMGLVQVLLAVPFLANNPWGYLGRAFELSRQFFFKWTVNWRFVGEDVFLSRGFSLALLGLHGAALAVFVTTRWLKPARKPLSRLVIPIVLGKSPFTGQEQRAVSRDVTPRFILTAILSANAVGLLFARSLHYQFYAYLAWATPFLLWRSGAHPVLQYVLWAAQEWAWNVYPSTPASSGVVVGVLATTVALVWWGGREDWEPRRGALKGAAATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SMW0</accession>
    <name>A0AAN6SMW0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Transcription elongation factor SPT5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">C8A01DRAFT_40441</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 9">The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the SPT4-SPT5 complex. Interacts with RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the SPT5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854551">
        <property type="protein sequence ID" value="KAK4033118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SMW0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032044">
        <property type="term" value="C:DSIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06081">
        <property type="entry name" value="KOW_Spt5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06082">
        <property type="entry name" value="KOW_Spt5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06083">
        <property type="entry name" value="KOW_Spt5_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06084">
        <property type="entry name" value="KOW_Spt5_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06085">
        <property type="entry name" value="KOW_Spt5_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09888">
        <property type="entry name" value="NGN_Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000018">
        <property type="entry name" value="Transcription elongation factor SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000029">
        <property type="entry name" value="Transcription elongation factor SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000054">
        <property type="entry name" value="Transcription elongation factor SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.940:FF:000005">
        <property type="entry name" value="Transcription elongation factor SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.940">
        <property type="entry name" value="NusG, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041973">
        <property type="entry name" value="KOW_Spt5_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041975">
        <property type="entry name" value="KOW_Spt5_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041976">
        <property type="entry name" value="KOW_Spt5_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041977">
        <property type="entry name" value="KOW_Spt5_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041978">
        <property type="entry name" value="KOW_Spt5_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057936">
        <property type="entry name" value="KOWx_Spt5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005100">
        <property type="entry name" value="NGN-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006645">
        <property type="entry name" value="NGN-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036735">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="NusG-like N-terminal" evidence="11">
        <location>
            <begin position="231"/>
            <end position="325"/>
        </location>
    </feature>
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        <location>
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        </location>
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        </location>
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        </location>
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        <location>
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        </location>
    </feature>
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            <begin position="865"/>
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        </location>
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        </location>
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        </location>
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        </location>
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        </location>
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        </location>
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        </source>
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            <dbReference type="SMART" id="SM01104"/>
        </source>
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            <dbReference type="EMBL" id="KAK4033118.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1080" mass="116302" checksum="350BF7966A180CCE" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SMZ9</accession>
    <name>A0AAN6SMZ9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CBM1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="8" type="ORF">C8A01DRAFT_49796</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854517">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:polysaccharide catabolic process"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="fatty_acyltransferase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CBD"/>
    </dbReference>
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        <property type="entry name" value="CBD_sf"/>
    </dbReference>
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        <property type="entry name" value="GDSL"/>
    </dbReference>
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        <property type="entry name" value="GDSL_Est/Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45648">
        <property type="entry name" value="GDSL LIPASE/ACYLHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_4G14700)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45648:SF22">
        <property type="entry name" value="GDSL LIPASE_ACYLHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_4G14700)"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
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        <location>
            <begin position="26"/>
            <end position="376"/>
        </location>
    </feature>
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        <location>
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            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
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            <end position="101"/>
        </location>
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            <end position="99"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4033644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="376" mass="39350" checksum="E002E0D322B17532" modified="2024-10-02" version="1">MGRSLTSTALALLAAAPGVITGVQAADVAGLWSQCGGINYTGPTTCVSGAVCTAYNDWYHQCTPGQASTTAKVTTSAATTLSTSTRTTSTTSSATSTSSPKPDDCALKFLITFGDSYSQTGFDIKSTKPSTSNPLGNPPLPGWTASGGLNWVGFLASKYNTSTLLAYNFAYGGATTNATIVPPYASTVLSFVDQVAQFSSSIAKKPSYAPWGDNALFGVWIGVNDVGNSWWKEDYDQIVEQIMASYFGQLQILYNAGARNFMLLTVPPIQRAPANLAGGADSQKAEAAAIAKYNAALAAGLAAFKTKNSGITSQIVDTTAPFNTALDNPTAYGSPDATCYNEDGKSCLWFNDYHPGIEINNLVAKAVADAWKGSYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SN07</accession>
    <name>A0AAN6SN07_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_40215</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854537">
        <property type="protein sequence ID" value="KAK4033327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SN07"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37844">
        <property type="entry name" value="SER/THR PROTEIN PHOSPHATASE SUPERFAMILY (AFU_ORTHOLOGUE AFUA_1G14840)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37844:SF2">
        <property type="entry name" value="SER_THR PROTEIN PHOSPHATASE SUPERFAMILY (AFU_ORTHOLOGUE AFUA_1G14840)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4033327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="191" mass="20953" checksum="CA0B5B22D91B25F2" modified="2024-10-02" version="1">MLGAFQDDVRKNPSLGEFVLLDRTAFRLPESGTVVLGCSLFSHVPPQSQMAVGMGLNDFFHTDGGWDVDAHNAAHERDLAWLNAQVADLEGSDDVQNIIIFSHWSPTLDARGADPRHAGSPVASAFATDLSGERCFRSGKVKVWVFGHTHYNCDFVVEREEGAGPLRLLANQRGYYFAQAEGFDGEKTVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SNC2</accession>
    <name>A0AAN6SNC2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_19468</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854520">
        <property type="protein sequence ID" value="KAK4033598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SNC2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042943161" evidence="1">
        <location>
            <begin position="20"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4033598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="384" mass="40737" checksum="C3DBE4A959C25F54" modified="2024-10-02" version="1">MLLRLCFSLLLGLAGAAFAAENAAQAADIRRRAVTTIATVVSWASTTVTVNPSDPTHWVTVATDHEYPFTTTSTTTSGCVSLSYIFPPPVPTSTSSDTTTTTVTRTIASRTTVTETRTDVPLTTRYSATVDVVSMSTGLTQHTVKCTNTAVMSFHVTTTATSTRTLAGSRTTVSNTEVCMTSTIRWLPGPDMTFVRTTSMPWYDEGHFTPGQGTILTFSEPTAQTTWVTTSTDLLVATTVICNNPRTVTTQTYFTVTQTLATTMVHRPRTDCSSSSPDSLATPIATPAASTMLLRRRNAAPKGMQHAPGNVRKQAETPVGTRTVTYTTTGLLSNGTIATITRTGIVETFTQTLTTIVMVGETITATATSYVSDCSVAAATPTSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SNG4</accession>
    <name>A0AAN6SNG4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Kynurenine 3-monooxygenase</fullName>
            <ecNumber evidence="11">1.14.13.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Biosynthesis of nicotinic acid protein 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Kynurenine 3-hydroxylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BNA4</name>
        <name evidence="14" type="ORF">C8A01DRAFT_48821</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>L-kynurenine + NADPH + O2 + H(+) = 3-hydroxy-L-kynurenine + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:20545"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57959"/>
            <dbReference type="ChEBI" id="CHEBI:58125"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.13.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="11">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the aromatic-ring hydroxylase family. KMO subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.9" evidence="11"/>
    <dbReference type="EMBL" id="MU854462">
        <property type="protein sequence ID" value="KAK4034871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SNG4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004502">
        <property type="term" value="F:kynurenine 3-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043420">
        <property type="term" value="P:anthranilate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070189">
        <property type="term" value="P:kynurenine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006569">
        <property type="term" value="P:L-tryptophan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019805">
        <property type="term" value="P:quinolinate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000129">
        <property type="entry name" value="Kynurenine 3-monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01971">
        <property type="entry name" value="Kynurenine_monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027545">
        <property type="entry name" value="Kynurenine_monooxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46028">
        <property type="entry name" value="KYNURENINE 3-MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46028:SF2">
        <property type="entry name" value="KYNURENINE 3-MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0274">FAD</keyword>
    <keyword evidence="2 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 11" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="8 11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 11" id="KW-0521">NADP</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 11" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="462"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="13">
        <location>
            <begin position="6"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="13">
        <location>
            <begin position="328"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK4034871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="511" mass="57033" checksum="42A10B6E6819BAF6" modified="2024-10-02" version="1">MEKKQKIVVVGAGPVGSLAALYAANRGHHVEIYELRSDLRDPSTTPLNFTKSINLALSERGINAMRHAGQPKLIEHVMGATIPMRGRMIHGKRATGALYEESQDYDVHGRSILAVDRGRLNERLLDILEEMRNVTFFFNHKLTGADFRKNKAWFELRESASAGAAQGQRAREIEVDFDLMIGADGAHSAVRYHMMKYTRMDYQQLYIDTMWCEFQIQPRPTAPDASLNSKFLISPNHLHIWPGKEFMFIAIPSGDGSFTCTLFAPASLYEHLESDRTGALVPPFFDKHFPGVTTLIPPAELIDSFHRNPHLPLISIKCSPHHHASSAVLLGDAAHAMVPFYGQGMNAGLEDVRILFDILDKHARMDELMLGADASASRARALAEYTAVRVPDAHAINDLALQNYVEMRASVLSPVYRLRKFLEEALSKYFPSLGWQTKYARVSFGNERYSEVVARSEHQGKMLVRGFVGLVGLPVLAGGVLLMLRYRRAVDVGLRAAFGSVDSIVELMTMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SP29</accession>
    <name>A0AAN6SP29_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_39268</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854487">
        <property type="protein sequence ID" value="KAK4034260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SP29"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23954">
        <property type="entry name" value="AMO1_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041367">
        <property type="entry name" value="Znf-CCCH_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21099">
        <property type="entry name" value="RAD201"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21099:SF2">
        <property type="entry name" value="SI:CH211-113E8.11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18044">
        <property type="entry name" value="zf-CCCH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="23"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="188"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="200"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="270"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="371"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="399"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="411"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="434"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="453"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="475"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4034260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="584" mass="59897" checksum="738D01BEF9288E32" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SPT7</accession>
    <name>A0AAN6SPT7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_47846</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Siderophore biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the NRP synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854425">
        <property type="protein sequence ID" value="KAK4038584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010106">
        <property type="term" value="P:cellular response to iron ion starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031169">
        <property type="term" value="P:ferrichrome biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="A_NRPS_SidN3_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.980:FF:000001">
        <property type="entry name" value="Non-ribosomal peptide synthetase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000015">
        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000033">
        <property type="entry name" value="Nonribosomal siderophore peptide synthase SidC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000024">
        <property type="entry name" value="Nonribosomal siderophore peptide synthase SidC"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003417">
        <property type="entry name" value="PRK04813.1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF1">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="534"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="1600"/>
            <end position="1677"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="2150"/>
            <end position="2226"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="3160"/>
            <end position="3236"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="4207"/>
            <end position="4280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="3687"/>
            <end position="3716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="3699"/>
            <end position="3714"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4038584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="4751" mass="520757" checksum="B8FBED61AF03F265" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SPY8</accession>
    <name>A0AAN6SPY8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_48473</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854448">
        <property type="protein sequence ID" value="KAK4035323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SPY8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00105">
        <property type="entry name" value="KH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="205"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="310"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="414"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="103"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="275"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="383"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="483"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="140"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="184"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="195"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="280"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="385"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="401"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="517"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4035323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="580" mass="60869" checksum="875816B96C9BDD9C" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SQ41</accession>
    <name>A0AAN6SQ41_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCZ1/INTU/HSP4 first Longin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_17465</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCZ1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854429">
        <property type="protein sequence ID" value="KAK4038437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SQ41"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035658">
        <property type="term" value="C:Mon1-Ccz1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013176">
        <property type="entry name" value="Ccz1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043987">
        <property type="entry name" value="CCZ1/INTU/HSP4_longin_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13056">
        <property type="entry name" value="VACUOLAR FUSION PROTEIN CCZ1 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13056:SF0">
        <property type="entry name" value="VACUOLAR FUSION PROTEIN CCZ1 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19031">
        <property type="entry name" value="Intu_longin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCZ1/INTU/HSP4 first Longin" evidence="3">
        <location>
            <begin position="16"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="122"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="356"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="451"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="713"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="122"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="362"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="401"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="504"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4038437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="819" mass="86119" checksum="B55476B0EBE69B0E" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SQ69</accession>
    <name>A0AAN6SQ69_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">lytic cellulose monooxygenase (C4-dehydrogenating)</fullName>
            <ecNumber evidence="15">1.14.99.56</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">C8A01DRAFT_37944</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the polysaccharide monooxygenase AA9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="15"/>
    <dbReference type="EMBL" id="MU854439">
        <property type="protein sequence ID" value="KAK4038106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SQ69"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF6">
        <property type="entry name" value="ENDOGLUCANASE IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042841428" description="lytic cellulose monooxygenase (C4-dehydrogenating)" evidence="16">
        <location>
            <begin position="17"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="17">
        <location>
            <begin position="17"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00044502"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00045077"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAK4038106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="257" mass="27884" checksum="2B29D96477728A1A" modified="2024-10-02" version="1">MKHLLAILAAATSASAHGWVENATIAGQYYQFYQPYQDPYMGDGAPQRISRKITSNGPVQDVTSIDLQCGGISSEGIVGSEPAPLHAPVEAGSTVNLKWTLWPDSHMGPMLTYMARCPDEGCDKWLPGEEPVFFKIHHDGRHTTDKAYPDDVWAVTPLMYPFNAGYNYTIPACLKPGAYLVRHEIIALHSAYAQGEAQFYPSCHQLTVTGSGTVVPPAEELVSFPGAYKADDAGILLNVWGPGNYTIPGPAVFKCPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SQ72</accession>
    <name>A0AAN6SQ72_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_48327</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854442">
        <property type="protein sequence ID" value="KAK4038033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SQ72"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="562"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="179"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="428"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="489"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="569"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="593"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4038033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="616" mass="64299" checksum="53860398192FCF27" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SQH4</accession>
    <name>A0AAN6SQH4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_47974</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854430">
        <property type="protein sequence ID" value="KAK4038406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011048">
        <property type="entry name" value="Haem_d1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052374">
        <property type="entry name" value="SERAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182:SF2">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51004">
        <property type="entry name" value="C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69322">
        <property type="entry name" value="Tricorn protease domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="9">
        <location>
            <begin position="386"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4038406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1465" mass="162338" checksum="310ECD3B4C289382" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SQJ8</accession>
    <name>A0AAN6SQJ8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_47137</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854401">
        <property type="protein sequence ID" value="KAK4039424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SQJ8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11058">
        <property type="entry name" value="CYP60B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF230">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="419"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4039424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="476" mass="54193" checksum="7128F67180F6BA86" modified="2024-10-02" version="1">MLLDTALQHLPSVLWTLLYAIPVLRYGPVVRLGPNHLSYTDVGAWKDIFGHRAGEHIKLQENPKSRMFYRDQIIDRSKTDATNIIDADREEHSRLRRAVAGGFSEKAMREQEPVIAGYVDMLVDGIRRRSEKGEEVDIVKWYNWATFDVVGDLVFAESFGCLEGERGHPFVNLVTGLAAQAAEFTAMKYAGLQKVPGFKWGLNKVVKFVAKDLFSEMQRVMGAKLQHRLEVKEERTDLFEGLMSKREEWNLDMNRLQANAAILAAAGSETTASLLTGVSFLLLQNPDAMEKLKHEVRSSFNGVADITITSVGRLPYLLACLNEGLRRYPPAVSNLPREVHEGGEMICGEFVPEETIVEVQHYAMNHSSQHWHDPFAFKPERWLNKVDSELGEAKERGEKDADGDRLEAMQTFSVGPRNCVGRNLAYAEMRLIMARIIFEFDMELADQCRDWLKNARVYTIWEKEPLYVRFTPVKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SSW8</accession>
    <name>A0AAN6SSW8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed RNA polymerase II subunit RPB9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">DNA-directed RNA polymerase II subunit 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">C8A01DRAFT_45638</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854363">
        <property type="protein sequence ID" value="KAK4041090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SSW8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001193">
        <property type="term" value="P:maintenance of transcriptional fidelity during transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006283">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10508">
        <property type="entry name" value="Zn-ribbon_RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000008">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012164">
        <property type="entry name" value="Rpa12/Rpb9/Rpc10/TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001529">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034012">
        <property type="entry name" value="Zn_ribbon_RPB9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02150">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00661">
        <property type="entry name" value="RPOL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00466">
        <property type="entry name" value="ZF_TFIIS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS-type" evidence="14">
        <location>
            <begin position="247"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="74"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="74"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00042129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK4041090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="287" mass="30830" checksum="75BCB5FC53A75282" modified="2024-10-02" version="1">MSSPAASASGDRKKPVEQITFRFCSECSNMLYPKEDEVDRKLMFTCRTCNFSEEATSSCIFRNAMNNAAGETAGVTQDVGSDPTVGSPSSLSSDAADLSGRRGSGSSSSTASACVSPCLGCGRMIICETCGDHFSMLSADPDTPELEVDEASVLEFDPDVDMDGDDHELDVDLDDVEIVTWTGESLDELGALMSRTEDFFGLGGMDFGMDEKESALIHASGLSDTFQPSLSIIRQYGIAPTSTLPRAKRSCPACNHQEAVFFQSQQRSAETGMKLFYVCCDCGNIFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SSX7</accession>
    <name>A0AAN6SSX7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ankyrin repeat domain-containing protein 50</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_33964</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854348">
        <property type="protein sequence ID" value="KAK4041974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
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        <property type="entry name" value="Dendritic_Spine_Reg/Scaffold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24166:SF48">
        <property type="entry name" value="PROTEIN VAPYRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24166">
        <property type="entry name" value="ROLLING PEBBLES, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="5">
        <location>
            <begin position="395"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1009"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1043"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1077"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1110"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1144"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1177"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1210"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1243"/>
            <end position="1275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="43"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="346"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1264"/>
            <end position="1285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1271"/>
            <end position="1285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4041974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1285" mass="143728" checksum="67B9D69DC1023559" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6ST72</accession>
    <name>A0AAN6ST72_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_45452</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854358">
        <property type="protein sequence ID" value="KAK4041390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6ST72"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF29">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G06680)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="361"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="400"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="442"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="473"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="510"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="541"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="280"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="286"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4041390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="583" mass="63965" checksum="B19D83F204E34197" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6ST76</accession>
    <name>A0AAN6ST76_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_45464</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854358">
        <property type="protein sequence ID" value="KAK4041405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6ST76"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF309">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14510)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="3"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="308"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4041405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="422" mass="46095" checksum="C3267956C9CD043B" modified="2024-10-02" version="1">MHAIIMGAGPAGLAAALALHQQSTDSAPFQVTVLELRAGVQTIGGAVNLTPLAMRYLDALGVGPRLRPLGAKVSYIEMLSHRTGSSLGRLWPDVDAIRVLRQDLVEAMLQTARAVPGDQLRLRFGAKVASIEELGDASGEGSVKVSFTDTASGREETIQGDFIIGCDGIHSFVRSSLVDPTRQKTYSGRATAYGFVTVSQPGNAGITAADGSPAVNISTLVSGQLGSLLLTFFEPSLKKLYLANVIAQPEKQDWRDGKRATGEDKEALQRDFLRRFRGGKLAGLEDAVRRCEEWVSFPVYMLPPGGVWSKGRALLLGDAAHAMPPQGESTGIAIEDGMLLARVFSRRDTRSISQMLADYEALRRPVIKKAYDEATFRWEKVGERSWFGMVLMEWLTVTYIWSMNYWSKNSFGRDVRTLDLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6STC9</accession>
    <name>A0AAN6STC9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_13975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854341">
        <property type="protein sequence ID" value="KAK4042424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6STC9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="178"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4042424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="592" mass="67371" checksum="1E7D28991C6A1393" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SU47</accession>
    <name>A0AAN6SU47_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">amidase</fullName>
            <ecNumber evidence="3">3.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_44738</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a monocarboxylic acid amide + H2O = a monocarboxylate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35757"/>
            <dbReference type="ChEBI" id="CHEBI:83628"/>
            <dbReference type="EC" id="3.5.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.4" evidence="3"/>
    <dbReference type="EMBL" id="MU854344">
        <property type="protein sequence ID" value="KAK4042216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SU47"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1300.10:FF:000003">
        <property type="entry name" value="Amidase signature enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF10">
        <property type="entry name" value="ACETAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="5">
        <location>
            <begin position="65"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4042216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="778" mass="85705" checksum="7D483FE2A076CEE8" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SUQ9</accession>
    <name>A0AAN6SUQ9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase CmcJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_43798</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asaB hydroxylase/desaturase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854329">
        <property type="protein sequence ID" value="KAK4043312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SUQ9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044053">
        <property type="entry name" value="AsaB-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041278">
        <property type="entry name" value="CmcJ_NvfI_EfuI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598">
        <property type="entry name" value="BLL6449 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598:SF3">
        <property type="entry name" value="OXIDOREDUCTASE AN1597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4043312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="275" mass="32034" checksum="879C0C1BE6E7764F" modified="2024-10-02" version="1">MEQLVLPVKSQISYIRKLPIYEKEKPFQILFDIPPGVGDQRRTNIEFESREQSFTNIRDRLANFTLDKNGFEICSGPLTWSSGELADQQVIQDTYLPEVERILKRNVTGGFDKVFFFDWRLRDSQLPTEPSITDMNDLSVWLRPVSYVHIDHAPRAVVSRTRLLLGDEADFLLRGRVRVINVWRPLDHPVEDYPLAFCDASTLRDEDLVECDHVRRKYKGATLFPNHHPDQKFYFLRDQQQEAVTLLKIFDSDTSVVARAETTLFGGMTHTRARY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SUZ3</accession>
    <name>A0AAN6SUZ3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Vacuolar protein sorting-associated protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">C8A01DRAFT_43993</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the proteasome-dependent degradation of fructose-1,6-bisphosphatase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854332">
        <property type="protein sequence ID" value="KAK4043071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000473">
        <property type="entry name" value="Vacuolar sorting-associated 1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1240">
        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019762">
        <property type="entry name" value="Dynamin_GTPase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003130">
        <property type="entry name" value="GED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF220">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02212">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23627">
        <property type="entry name" value="LisH_WDR26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00302">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00410">
        <property type="entry name" value="G_DYNAMIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CTLH" evidence="11">
        <location>
            <begin position="159"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="352"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="395"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="Dynamin-type G" evidence="13">
        <location>
            <begin position="655"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="12">
        <location>
            <begin position="1232"/>
            <end position="1319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="20"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1156"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="39"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="73"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00073589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK4043071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1319" mass="146272" checksum="7E357F7FE0775347" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SUZ7</accession>
    <name>A0AAN6SUZ7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_13403</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854332">
        <property type="protein sequence ID" value="KAK4043086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SUZ7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4043086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="200" mass="21982" checksum="9454DC26B0D9EECF" modified="2024-10-02" version="1">MIIVGQVFVVVDFDFAILGDIYEVVDGHPGLAVLVQPVGVLALQNVVEAGTDERHRLLGGAQHVNRVSHRVGLRLNDGLVGQRRERRQEGGPGHQEGVDEQRLADIQRLQYVFLRDGIGQAVVPVDGADDAVPDRIQKELRGAHDTGALVRVAHLEVCHLARVRWLSKPSQTRGLTWAAALKGGTRKCRPRCFRMVCRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SVH1</accession>
    <name>A0AAN6SVH1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_31095</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854317">
        <property type="protein sequence ID" value="KAK4044599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SVH1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042816412" evidence="2">
        <location>
            <begin position="22"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4044599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="441" mass="49224" checksum="BD895801DA9361EC" modified="2024-10-02" version="1">MKSALSAGLVAALLCPAAVIAGSTCPKTAHGSNRITCRVDVDRTERHEKDQGHHKRGHKNEVEIKRTVDTYTWSFFWKYIITDDCPKTMAHLSSIIPWLANTHHQVKCRVEIGWAPDHGPHGDTFNGRGNESLWDYDGHSQIDWTSLPAKMSWPLYASIDRPEHFHGKSGELGAKYEKANTGEDEFTFDIHHGDCGDFSHCWGHDDRDEHSEFREIDEGHHGKNGKNDKRGHKKQEIRTSVSDHHRKFGGHYDTKNLYSCWVFEKYHHITRQSTERKEKKKGKHGDKNDNDDYNMGPIVPYHSPSWSTCEPHLPLPPPCEEECHGDSCAPKQDDCKGESCGGKQQGDNNCNGGDCGGKQEVSQGCQGASCGGKQDVAKGCHGRTCGRGEEDCDDDDCSDDGSDDDCEDDCSEDDPSDSDDGSDDDCEDDCTEDEDKHRCGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SVV1</accession>
    <name>A0AAN6SVV1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">U3 small nucleolar RNA-associated protein 11</fullName>
            <shortName evidence="6">U3 snoRNA-associated protein 11</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_42650</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Involved in nucleolar processing of pre-18S ribosomal RNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the ribosomal small subunit (SSU) processome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 6">Nucleus</location>
            <location evidence="2 6">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the UTP11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854318">
        <property type="protein sequence ID" value="KAK4044467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SVV1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007144">
        <property type="entry name" value="SSU_processome_Utp11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12838">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12838:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03998">
        <property type="entry name" value="Utp11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015952">
        <property type="entry name" value="U3snoRNP11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="66"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="129"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="15"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="137"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="179"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="251"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR015952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4044467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="262" mass="29956" checksum="27203697E2234378" modified="2024-10-02" version="1">MSSLRNSVQRRSHRERAQPLERQRLGLLEKKKDYQKRAKDYNKKKAVLKSLRQKAADRNEDEFYFGMMSRKGPGASITRGKAYTGNVDGDRGNRAMDVDTVRLLKTQDLGYVRTMRNVAAKEVRELEERFVLAGGTEQDDDEDDDDSDDDMRPSRSGPQKPKKIVFFDGAEEREQAVEQAEDEDEAMQGMEDEDSQKAAAAGKKAQHLEKLERRLKAARKKLKTLKDAEYELELQKAKMAKTATSGGITKSGRKIKVRERKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SVV3</accession>
    <name>A0AAN6SVV3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 15">Signal peptidase complex catalytic subunit SEC11</fullName>
            <ecNumber evidence="4 15">3.4.21.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">C8A01DRAFT_12408</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.</text>
            <dbReference type="EC" id="3.4.21.89"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of the signal peptidase complex (SPC) composed of a catalytic subunit SEC11 and three accessory subunits SPC1, SPC2 and SPC3. The complex induces a local thinning of the ER membrane which is used to measure the length of the signal peptide (SP) h-region of protein substrates. This ensures the selectivity of the complex towards h-regions shorter than 18-20 amino acids. SPC associates with the translocon complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the peptidase S26B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.89" evidence="4 15"/>
    <dbReference type="EMBL" id="MU854321">
        <property type="protein sequence ID" value="KAK4044150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SVV3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009003">
        <property type="term" value="F:signal peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.109.10">
        <property type="entry name" value="Umud Fragment, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019756">
        <property type="entry name" value="Pept_S26A_signal_pept_1_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001733">
        <property type="entry name" value="Peptidase_S26B"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02228">
        <property type="entry name" value="sigpep_I_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10806">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10806:SF6">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00728">
        <property type="entry name" value="SIGNALPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="LexA/Signal peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00501">
        <property type="entry name" value="SPASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 15" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 15" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="131"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU362047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK4044150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="172" mass="19024" checksum="C7F9B604C9E85258" modified="2024-10-02" version="1">MLSSLQNPRQAAAQLMNFGLILSTAFMMWKGLSVITDSPSPIVVVLSGSMEPAFQRGDLLLLWNRNLMSETNVGEIVVYNVKGKDIPIVHRVVRKFGIGPDAKLLTKGDNNAADDTELYARGQDYLNRKDIVGSVVGYMPFVGYVTIMLSEHPWLKTVMLGIMGLVVVLQRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P3S5</accession>
    <name>A0AAN6P3S5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_21532</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854969">
        <property type="protein sequence ID" value="KAK4031218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P3S5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39603">
        <property type="entry name" value="CYANOVIRIN-N DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39603:SF1">
        <property type="entry name" value="CYANOVIRIN-N DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043049222" evidence="1">
        <location>
            <begin position="19"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4031218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="175" mass="18066" checksum="7F00EC8E0CE420D5" modified="2024-10-02" version="1">MIFTELFLASLALAPALALPAAPTEGDSEVFSFSKWIDGIIANPDGNNLTPDEAVAAWSASSNGTRAGALDKRAPLVCTGYNFCQVADAVWCINYLATLGRQGTRCEVTTAANWCGHGSARLNGLTAVGATTSSNCNDVARGGGYIMDACTRSDGLVSGTAPAYGNGNLIVEIRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P535</accession>
    <name>A0AAN6P535_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Class I glutamine amidotransferase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_21004</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854693">
        <property type="protein sequence ID" value="KAK4031839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P535"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03139">
        <property type="entry name" value="GATase1_PfpI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052158">
        <property type="entry name" value="INH-QAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43130">
        <property type="entry name" value="ARAC-FAMILY TRANSCRIPTIONAL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43130:SF15">
        <property type="entry name" value="THIJ_PFPI FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G14240)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042995891" evidence="1">
        <location>
            <begin position="22"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="DJ-1/PfpI" evidence="2">
        <location>
            <begin position="93"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4031839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="272" mass="29604" checksum="AB7172C7668763E9" modified="2024-10-02" version="1">MRAFLAAVGGLLLSSAWLALGQNTPENEFNRRRTLSFGIIIFPGWEPLDVFGPLEILFSLSATYKITLSIIAKETGPVSAGYPPHIMVPGQPPADYSYMLQPKLVATHTFRDAPALDVLLVPGGVGTMALEQANDTSIETFLRNRFESLDYLLSVCTGSALLATSGLLDGRRATTNKALWGLVTNHGENVTWVPSARWTHDGKIWTSSGVASGIDMMYAFLKHLYGETDPVLIAAMNGIEYAPHTDPDWDPFSIVHNVRTCNSLLGRGQQPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P675</accession>
    <name>A0AAN6P675_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_21290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854787">
        <property type="protein sequence ID" value="KAK4031490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P675"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35179:SF1">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35179">
        <property type="entry name" value="PROTEIN CBG02620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="155"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4031490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="336" mass="37334" checksum="E1FBFCC458F28015" modified="2024-10-02" version="1">MVRDQKTSEEGLLIAASFFGASMAVVAFDCTKAGRQSYRSWRRCHKVNAYILMLWSEISACFVASICNFLFLLSRIQPSTSSLTATQIQCLMQILANRLSLILYNPDKERLLKAGLFIAIGIINVGEFCIWIPARLQISETFIRINNVWDRAQKVILAIIDLSLNWYFMWLVKSKLVANGLTQYNLVYKCNLAMVTVSISLDLLLIGLMSLPDDAVYIQTHTLAYLTKLNIEMNMADLLAKVVKKSTERRSSFPTTDLGAGGGNFQYQARGRSPRCADDHGQPGVDIQQPGPVGGGRDAGDAGDRDSVDETQGRPPSHADEHKQSCVYLESSRSTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P6N0</accession>
    <name>A0AAN6P6N0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">alcohol O-acetyltransferase</fullName>
            <ecNumber evidence="6">2.3.1.84</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Alcohol O-acetyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_20231</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Displays enzymatic activity both for medium-chain fatty acid (MCFA) ethyl ester synthesis and hydrolysis (esterase activity). MCFA are toxic for yeast and this enzyme could thus be involved in their detoxification by esterification.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an aliphatic alcohol + acetyl-CoA = an acetyl ester + CoA</text>
            <dbReference type="Rhea" id="RHEA:17229"/>
            <dbReference type="ChEBI" id="CHEBI:2571"/>
            <dbReference type="ChEBI" id="CHEBI:47622"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.84"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.84" evidence="6"/>
    <dbReference type="EMBL" id="MU854580">
        <property type="protein sequence ID" value="KAK4032731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P6N0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008126">
        <property type="term" value="F:acetylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004026">
        <property type="term" value="F:alcohol O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051792">
        <property type="term" value="P:medium-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051793">
        <property type="term" value="P:medium-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000137">
        <property type="entry name" value="EEB1p Acyl-coenzymeA:ethanol O-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050960">
        <property type="entry name" value="AB_hydrolase_4_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012020">
        <property type="entry name" value="ABHD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794">
        <property type="entry name" value="ABHYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794:SF63">
        <property type="entry name" value="ALPHA_BETA HYDROLASE 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005211">
        <property type="entry name" value="Ab_hydro_YheT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="9">
        <location>
            <begin position="122"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="332"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00050620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00054277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00066969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00080774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR005211-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4032731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="422" mass="47091" checksum="A50224E9304662A1" modified="2024-10-02" version="1">MDWFGRAKVAFTHSPSPLALQRKDGTATDLLKVCEATTPPCQLNPLLFNGNLQTMWTAVKEHGPPIYYRRRIFDADHKTYTGTFTVDFAVDPHQDVEESLPPRTAFFSEDDFAKIGSDDSRPMLIVLHGLSGGSHEIYLRHAIAPLVMDGGDWEVCVVNARGCANSKVTSGVLFNARATWDVRQVINWARQTFPNRPLFGLGFSLGANILTNYVGEEGANCPLKAAISVGNPFDLEVANKALQRTMLGKVYSRVMGTNMKKLINTHKDAVLQHTNLNYDRIQNVTYLHEFDREVQTVTWGYPTENAYYRDASSSDAVLAIRIPFLAISALDDPIAVYDAIPFQEFTQNPYTVLVTTSLGGHLSWFEIGGGRWHARPICNFLNHMATEINLDAIIPNANGAKPETQFVTEFDPVRRKLQIISN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P712</accession>
    <name>A0AAN6P712_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_40610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854563">
        <property type="protein sequence ID" value="KAK4032926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P712"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4032926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="330" mass="36110" checksum="B2808DC82F072D86" modified="2024-10-02" version="1">MSYGTTTTRGGVRKVSGEEDPNVIPRTAPLGFLGRLPFKIVGSLRYKPSAANLREHPGGGGGANQGYHGDEGRAGEHEPLLGAGDEEGARRQQGTRPRSDTTTSGDTSSSYRSRGDLFPSDGEGDEDAVPLDDEFTVALERVDDRGSTKTRSSKGKRPADRDRDRDKGLSRTVSRTTISSANTPDETKWDSNPVSPVREENVARVSSLEDLQREEEQAEREEYEEIERRRRAASQLAMQRGLNKDDFEAPEMADETKDDTLDNGSRHPPAEEPVSGINRTAIDDGELEEVEEPKPPPPTPPEPVPLQGKDTNGKLRVESTFVPARLPHFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P7D6</accession>
    <name>A0AAN6P7D6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_19951</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854555">
        <property type="protein sequence ID" value="KAK4033054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P7D6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051651">
        <property type="entry name" value="DMTF1_DNA-bind_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46380">
        <property type="entry name" value="CYCLIN-D-BINDING MYB-LIKE TRANSCRIPTION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46380:SF2">
        <property type="entry name" value="CYCLIN-D-BINDING MYB-LIKE TRANSCRIPTION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH myb-type" evidence="6">
        <location>
            <begin position="565"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="5">
        <location>
            <begin position="565"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="5">
        <location>
            <begin position="612"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="259"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="790"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="54"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="84"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="167"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="266"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="293"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="810"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="832"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="892"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="935"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1024"/>
            <end position="1033"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4033054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1033" mass="113603" checksum="A9629241C1BB20B8" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P7F5</accession>
    <name>A0AAN6P7F5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ornithine carbamoyltransferase, mitochondrial</fullName>
            <ecNumber evidence="4">2.1.3.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Ornithine transcarbamylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">C8A01DRAFT_40474</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>carbamoyl phosphate + L-ornithine = L-citrulline + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19513"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.3" evidence="4"/>
    <dbReference type="EMBL" id="MU854553">
        <property type="protein sequence ID" value="KAK4033084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P7F5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004585">
        <property type="term" value="F:ornithine carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019240">
        <property type="term" value="P:citrulline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:L-arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1370:FF:000017">
        <property type="entry name" value="Ornithine carbamoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1370:FF:000009">
        <property type="entry name" value="Ornithine carbamoyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="entry name" value="Aspartate/ornithine carbamoyltransferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002292">
        <property type="entry name" value="Orn/put_carbamltrans"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00658">
        <property type="entry name" value="orni_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45753">
        <property type="entry name" value="ORNITHINE CARBAMOYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45753:SF3">
        <property type="entry name" value="ORNITHINE TRANSCARBAMYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00102">
        <property type="entry name" value="OTCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="Aspartate/ornithine carbamoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aspartate/ornithine carbamoyltransferase carbamoyl-P binding" evidence="13">
        <location>
            <begin position="29"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Aspartate/ornithine carbamoyltransferase Asp/Orn-binding" evidence="12">
        <location>
            <begin position="193"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK4033084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="359" mass="38465" checksum="B89A2643D53614A5" modified="2024-10-02" version="1">MSPRAACRTIKSAMAHLQTRSLSSASGPRHLLSISDLSPAEFTKLVLNASSHKAAVKAAFAAGEQPPKSLHGALTGKTVAMMFSKRSTRTRVSTEAAVQLMSGHPMFLGKDDIQLGVNESLYDTSVVISSMTSCMVARVGAHKEVADLAAHSSVPVINALSSDYHPLQTIADFQTIHETFPSRTPSDSSLGLEGLKVAWVGDSNNVLFDLAIGCVKMGLDIAVASPAGYGIPEAMKQVILAAGEGVANPGKLVETHVPEEAIKDADILVTDTWVSMGQEEESQKRLRAFAGYQITNELAKRGGAKPDWKFMHCLPRHPEEVDDEVFYGSRSLVFPEAENRLWAAVAALEAFVVNKGKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P7P2</accession>
    <name>A0AAN6P7P2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SET domain-protein 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_50117</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854541">
        <property type="protein sequence ID" value="KAK4033273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P7P2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053185">
        <property type="entry name" value="SET_domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332:SF6">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043050502" evidence="1">
        <location>
            <begin position="23"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="2">
        <location>
            <begin position="123"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4033273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="411" mass="45667" checksum="5739AFAD989A4902" modified="2024-10-02" version="1">MLIRASLSRHSFLSLLPFVTTAVQTQCRWNPTLLSLRPTASCPLPVDDGTPAPLMASRGVPWTHPPHCVIANFAGPTANGIAVIASPETAADVVAAVKDPLPAWSSRRHLARHGRLRTETSDLPYAVTPIPRKGLGVIATKRINQFETIITSFPAMVADNKFFPSKQDHGPVEGAQLFQKALDQLPDKERFLNLARSKGEHVHVVEDVVRINAFGITVDGREIKGLYPEIARLNHACGATAYNRFTKKDLDMSAIDTRDIEPGEEITISYIPLGMPTAYRTRALSKWGFTCTRDLCSAASETRGASDQRRERLLEVYYTIQDESTSYNTLVELTHELIELVQVERLLGKLGGYYQALMQIYYGIGDPDTARKYGHASLKFANIFSDTDGGFCTGLKRDLERIDREVQKRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P7W4</accession>
    <name>A0AAN6P7W4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Hemerythrin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_41560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854663">
        <property type="protein sequence ID" value="KAK4032003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P7W4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12108">
        <property type="entry name" value="Hr-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.520">
        <property type="entry name" value="nmb1532 protein domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053206">
        <property type="entry name" value="Dimeric_xanthone_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38048">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38048:SF2">
        <property type="entry name" value="HEMERYTHRIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemerythrin-like" evidence="1">
        <location>
            <begin position="36"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4032003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="255" mass="28471" checksum="459FC36298157FE7" modified="2024-10-02" version="1">MAPVYADHPFSLVPTPLFLAEDSQATDVFDELASEMALVHNIIIRGLNSIYLQAPHIKPADEKSFGSYMVNWYNLVHSHHNGEETMFFPAIERLTGVEGLMDANIEQHKAFHDGLDRCKAYADAVVAGKEKYEGSRVIEIIDDFGPALVKHLSDEIPTILGLRQYADKLAELPKLFQEEADSAMKGISLLGLVWAFSNIDSQYENGRWQSWPPAPAPLKILIRSVLWWTNAEARKFGAIDRTGNMKHLSAVPQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P7X7</accession>
    <name>A0AAN6P7X7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_50751</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854607">
        <property type="protein sequence ID" value="KAK4032467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P7X7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4032467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="159" mass="18081" checksum="24542A759A727B8E" modified="2024-10-02" version="1">MQDQYTTVHYHYQYFPLGIGEVDDSIVLKYPLTAGRDLERLEAERKILEAILPYKNILGFKGSTDTGIYLERAPNGTVAEYILESDLHVKLSDFQGKLLAKDSTVLVDGCSIEPYRFSLPRDNFRADVKTDLFVLGCTLYFILLGYTIFPDIGNRDKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P8S7</accession>
    <name>A0AAN6P8S7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ubiquitin-conjugating enzyme/RWD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_39682</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854507">
        <property type="protein sequence ID" value="KAK4033834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P8S7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23799">
        <property type="entry name" value="UBCc_UBE2J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000093">
        <property type="entry name" value="Ubiquitin conjugating enzyme (UbcF), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="3">
        <location>
            <begin position="13"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="199"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="213"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="223"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="253"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4033834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="313" mass="33556" checksum="A150D2823A3F6FB5" modified="2024-10-02" version="1">MSTTTPKLNSKSPTIRRILREAHELTTAPSADYHAVPLETDLFEWHFTLRGPPNSPFEAGIYHGRIVLPPSYPLRPPSFRFLTPSGRFETNREICLSISGHHEETWQPAWGIRTALVALRSFMETDVKGQLGGMTAGEGVRRRMAGESGGWKCGVCGGGKSNREILGECEERVKEMGEREKEEVKVPEELKMGWRDEMEAAAAAQQKKKNEGEGEGDGESDGLAEGFVQTAPVSSSPGEPSSGGTAVAGGSAVPPPTRTVPSPSPLPVAAGPALQQVQRVQQVAADETAVWLDRLIVAVAVLLAAVVAKVMLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P9A3</accession>
    <name>A0AAN6P9A3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_49479</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854497">
        <property type="protein sequence ID" value="KAK4034060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P9A3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4034060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="191" mass="20720" checksum="B6892FE308719079" modified="2024-10-02" version="1">MIQDAFHHQVRQHGDELISFSIEYPESQVNWVWLVGSADLATEQAVLQFFQTDVGKRSLESDVVEFKLASTLLRLPGSQAAEDPICHPPAGLTAATVPLQNGQEVTIMSGSGSPPHVPAICVPVATGGWLQVSPRMHFSHLLLVKPQDQQTHADPAYLRGWLVAANKSTVHRHVAAIVGARGYLVAPPRTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P9U0</accession>
    <name>A0AAN6P9U0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_18826</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854483">
        <property type="protein sequence ID" value="KAK4034345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P9U0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38696">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38696:SF1">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4034345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="265" mass="29401" checksum="3E93A62866B004C9" modified="2024-10-02" version="1">MDQKTAFNSDSKELPVAPRPVFPAPSAAGSSAPLFRTPLACITLNHGDRIRFINLPEPDVAALRGVVQSTWPKGIQKIAPYGQAQELKLGGWPWRRTLAGFDDSRRLLIRLLETLHDRGWVLHGAIDLSKKEHDTDTLVFRHQSPPPPSSDWLVVSVDDYDKLRIVSSPPPDLAAAVIGCFGPAVKRHQMDNSHLEIKFHGYPFCPSGTDEVNAGVMLLALLGTLEAFGFTLYANFVHTWGERPTDVLVLHRQKGWAPGMPIWHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P9W2</accession>
    <name>A0AAN6P9W2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_41416</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854644">
        <property type="protein sequence ID" value="KAK4032132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P9W2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="2">
        <location>
            <begin position="53"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4032132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="290" mass="31429" checksum="786CECDABB1C0C08" modified="2024-10-02" version="1">MSTKTIYQSTPEEWDAYVSEYAAFNKNSPFSLSVPLLVKADGARPFSTATGILDNGCGTGKVTSELIDRYAADLPAAARLLASDFSPAMVKFVQELKSEPPQASNPVWRRVEPLVQDAQNLDAIPDSSLSHVLSGMVLFAVSDADKALAEARRTLEPGGVLALTAGMVFPWIDIWTYAQPLRPGDLWELSPAEGWRSVEAVEALVTRAGFREVSVDVTTMPMKMAPPMLRGFLRNFIKSKNPAAVTVFAGFSEEEFEKALDLIVEGAVKDYGRGEEVVLDGKVAVVSALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PA48</accession>
    <name>A0AAN6PA48_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2-nitropropane dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_38968</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854474">
        <property type="protein sequence ID" value="KAK4034576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PA48"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332:SF31">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G09850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4034576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="377" mass="40243" checksum="ECC4B5CC1997387A" modified="2024-10-02" version="1">MASPQKIRTDLTDLFKINHPVLLAGMNVAAGPKLAAAVTNAGGMGVLGGINYTPDMLRDQIDELKSHLTDKKAPFGVDLLLPQVGGNARKTNYDYTKGKLDQLIDIIIESGAKLFVSAVGVPPKHVVEKLHKNGIVYMNMIGHPKHVKKCLDLGVDIICAQGGEGGGHTGDIATTILIPSVVEACKGHKSPLTGKPVQVVAAGGIHNGQLLAASLMMGASGVWVGTRFVLSEEAGAPESHKEAVRTASFDDTIRTLIFTGRPLRVRKNPYIMNWEEERAQEIKELTSRGKLPYEADLDKVMSGEAEATPAIKGSGLMNASSDDDGDVDDLLDQFRPFLMGQCAAVVNDKKPAKEIVDEFVNDAAACLKKGNSYVAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PAA4</accession>
    <name>A0AAN6PAA4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_40892</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854586">
        <property type="protein sequence ID" value="KAK4032661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PAA4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32343:SF10">
        <property type="entry name" value="RNA-BINDING REGION RNP-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32343">
        <property type="entry name" value="SERINE/ARGININE-RICH SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="3"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="68"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="245"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="68"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="251"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4032661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="295" mass="31397" checksum="05A03BF7658DC4F4" modified="2024-10-02" version="1">MATTVYVKNIGAQTENKEIQDFFSFCGKISSIDITEGPHKSATVTFDKETAARTALLLNHTRLGGNEITVTGEDNISTPPHDTGDTSDRDADAASTLTQEEKPRSRILAEVLAHGYLVADTGLQRAIALDEQHNISARFVSTLKQLDERTRATDHARAADASYGLSQRAGSLLTGLGSYFEKAGNTPTGKRIVGFYTTSQRQVQDIHAEARRLADLKKEETGGSLYKGLGLDKVPGLDTVLGKFHQQGGAKEGEGAAAPEEKKEVPGAAPADAVATESAQKPVKPSGTGNPETIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PAV6</accession>
    <name>A0AAN6PAV6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MepB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_40938</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase M3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854590">
        <property type="protein sequence ID" value="KAK4032612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PAV6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06455">
        <property type="entry name" value="M3A_TOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000074">
        <property type="entry name" value="Metalloprotease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.40">
        <property type="entry name" value="Endopeptidase. Chain P, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.10">
        <property type="entry name" value="Neurolysin, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024077">
        <property type="entry name" value="Neurolysin/TOP_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024080">
        <property type="entry name" value="Neurolysin/TOP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PROTEASE M3 THIMET OLIGOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804:SF84">
        <property type="entry name" value="SACCHAROLYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M3A/M3B catalytic" evidence="8">
        <location>
            <begin position="227"/>
            <end position="727"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4032612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="732" mass="82172" checksum="654DB17B41004B7E" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PAZ0</accession>
    <name>A0AAN6PAZ0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="16">1.3.8.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">2-methyl branched chain acyl-CoA dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">2-methylbutyryl-coenzyme A dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="31" type="ORF">C8A01DRAFT_40545</name>
    </gene>
    <organism evidence="31 32">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="32" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="32">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>(2R)-2-methylbutanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = ethylacryloyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:65296"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:156439"/>
            <dbReference type="ChEBI" id="CHEBI:156440"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:65297"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>(2S)-2-methylbutanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-2-methylbut-2-enoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:48256"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57337"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:88166"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:48257"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>2-methylbutanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-2-methylbut-2-enoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:43780"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57336"/>
            <dbReference type="ChEBI" id="CHEBI:57337"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="1.3.8.5"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:43781"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>2-methylpropanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = 2-methylpropenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:44180"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57338"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:62500"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:44181"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>butanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:24004"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57332"/>
            <dbReference type="ChEBI" id="CHEBI:57371"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:24005"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>hexanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-hexenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:43464"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:62077"/>
            <dbReference type="ChEBI" id="CHEBI:62620"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:43465"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>valproyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-2-propylpent-2-enoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:65344"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:156457"/>
            <dbReference type="ChEBI" id="CHEBI:156458"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:65345"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 27">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="15">Amino-acid degradation; L-isoleucine degradation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; mitochondrial fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 27">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="31">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.8.5" evidence="16"/>
    <dbReference type="EMBL" id="MU854559">
        <property type="protein sequence ID" value="KAK4032991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PAZ0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003853">
        <property type="term" value="F:short-chain 2-methyl fatty acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046395">
        <property type="term" value="P:carboxylic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01158">
        <property type="entry name" value="SCAD_SBCAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000012">
        <property type="entry name" value="Acyl-CoA dehydrogenase short/branched chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000002">
        <property type="entry name" value="Acyl-CoA dehydrogenase short/branched chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000001">
        <property type="entry name" value="Acyl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
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        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
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        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
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        <property type="entry name" value="AcylCo_DH-like_C"/>
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    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF1">
        <property type="entry name" value="SHORT_BRANCHED CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
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    </dbReference>
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    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8 27" id="KW-0274">FAD</keyword>
    <keyword evidence="9" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="7 27" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12 27" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="32" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="30">
        <location>
            <begin position="60"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="29">
        <location>
            <begin position="174"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="28">
        <location>
            <begin position="281"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00037895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00039036"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00039850"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00041537"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00042821"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048235"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048307"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048592"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00049096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00049192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00049552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00051903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="EMBL" id="KAK4032991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="436" mass="47622" checksum="D46528F48D83139F" modified="2024-10-02" version="1">MRSFVRALRPAVRRSQAISAPRIRQPGFAAQCARPLSTTAVRRDASLADVAPTPITHFSEVETAMAETVQKFANDVILPKVRDMDEAEQMDPTVVEQLFEQGLMGVEIPEEYGGAGMNFTAAIVGIEELARVDPSVSVMVDVHNTLVNTAVIKWGSDALKKKYLPRLATNTVGSFCLSEPVSGSDAFALATKATETESGFKINGSKMWITNSMEAEFFIVFANMDPSKGYRGITAFIVDKDTKGFSIAKKEKKLGIKASSTCVLNFDDVEVPKENLLGERGQGYKYAISLLNEGRIGIGAQMTGLALGAWENAVKYVWNDRRQFGQLVGEFQGMQHQIAQSYTEIAAARALVYNAARKKEAGENFVMDAAMAKLYASQVAGRVSGLAVEWMGGMGFVREGLAEKFWRDSKIGAIYEGTSNIQLNTIAKTLQKEYTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PB71</accession>
    <name>A0AAN6PB71_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_38407</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854454">
        <property type="protein sequence ID" value="KAK4035133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018803">
        <property type="entry name" value="Ish1/Msc1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47372">
        <property type="entry name" value="DAUER UP-REGULATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47372:SF11">
        <property type="entry name" value="RE19971P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10281">
        <property type="entry name" value="Ish1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042968063" evidence="1">
        <location>
            <begin position="20"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4035133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="553" mass="61221" checksum="3A3E6E515F62A519" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PBK7</accession>
    <name>A0AAN6PBK7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_40155</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854534">
        <property type="protein sequence ID" value="KAK4033366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PBK7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF2">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4033366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="247" mass="27740" checksum="E2A6D0C261F57072" modified="2024-10-02" version="1">MSVTELARALPDTTSNHFRFMDLPPELRLQVYRHLLFAVQGIHLWCLAYREPTCPDPRHHPNICTTVLKLCRQITDEALSVLYGENTFVFLEYDIDRGTPQLHFPEATLLRIRKLRVVHPCGLNPYPPPDGRMPLAPWPAEPPNSPDIWRSVLANLNSLTLVLSVPCAGITAEEAAEEVARHAANYQAGATAAKAVMNFYQSGVPPSVAVHRRVLCHFNVCPSRSFETVGGKCEALHRYIEKIWLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PBU1</accession>
    <name>A0AAN6PBU1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_18725</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854478">
        <property type="protein sequence ID" value="KAK4034477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PBU1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF1">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4034477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="607" mass="68668" checksum="ED6EA4953914CF82" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PCA4</accession>
    <name>A0AAN6PCA4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleotidyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_37706</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854432">
        <property type="protein sequence ID" value="KAK4038319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PCA4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4038319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="176" mass="19764" checksum="658E77ECFD2A030B" modified="2024-10-02" version="1">MTLHYQRLEQAALDVIDALRQIPQFSDLGIAVIGGFARVHHNRGSRGTSDVDFIIDTAEIALEREIKQAILNLGGTDFSQEAHVFRHVLNGGTDYCRVDFFPRDICPYLPPAAQQVQHIPLNAIPFISPTDLIVFKIHSCGTRGDATKNKDDAVTPRLCFVRWPRRSRLHDSSKMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PCB1</accession>
    <name>A0AAN6PCB1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_40164</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854534">
        <property type="protein sequence ID" value="KAK4033377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PCB1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4033377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="313" mass="34476" checksum="BBAD2C7CF222586A" modified="2024-10-02" version="1">MGEKVLLPDTPHLSITLQAPIELSLTLPYPIRFTIRRLARGYPTDSQPCIIRWNPTIDAFSPPSGLVLLRHSLRNGGGCLEPIPVNHASGDPTGGGEDCLIPTGEDNQFWWELPAPGSEISVTATLPERYYRAINQAGGSFGPWGVYMLLFPGAELGVWDWGAVREHAHSGQGVKEGGAGMKLVVPGGARIHFTVVRFSDRRWPERDAYEAEHGFERANVAQREWRDREERKVMANRSRLGLSSPVELSDRMSGAPHFTVAVKGPVTVKSYEQIRVNLEFTYHGITGADGNLQTSTARPVAFHSWAFSGQTIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PCT0</accession>
    <name>A0AAN6PCT0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_17413</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854427">
        <property type="protein sequence ID" value="KAK4038516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PCT0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="28"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4038516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="498" mass="57303" checksum="0318126A0D7C2418" modified="2024-10-02" version="1">MLATMTDLKRTMDPLVAAQVYNRQHNPLCRLPDELLLLILPCIGDDHVALYCTRRVSRVLRHLIHDPAVWRYTEMPLSLRFSYLSESHWEIPEKEKTQLKRHLRADGMCDNCKLWCDVPVKGWSKRLDQYFKVGPIDPDWMARMRLTNPTCKFDSPITLDAPVHCRGCGLHHADWVFPPGTVGVPRQPYDAGEPNQLCLGHRGTVQLCEHTGVSWRAVEDHMTNWQDLKRGYRTWQACLDDFAVECRHPIHDRRCRPAQAPTWPRARLQTSRNHETTSVVLVLEWAPHSGVGAFVRGPHGRPLAAELRSLFQGYRQQGQPAEILMPARLGQLPEMVCFDPNTCRCLHYETGNSIDDPQGQRAADAADLGFLSLDCLGRHSHRNDIRLYGDCDRTVEMRQHWPRRGREPPPCLITTYRHRVVVCDDIMAWTTGPGGTKLHPTHEWFHAMDPDTYPRPLGHELPLCKDRGCMNYYKRPRMVSCIEPRGMFSPCQCPRQST</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PCV7</accession>
    <name>A0AAN6PCV7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RTA1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_49464</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854497">
        <property type="protein sequence ID" value="KAK4034041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PCV7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF13">
        <property type="entry name" value="RTA1 DOMAIN PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4034041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="310" mass="34572" checksum="59A85E557568141F" modified="2024-10-02" version="1">MADGTPVAGSVWFYAPTNVAPIPFAVLFGASGVFHLWQCIHYKSFRVTAYLPFCCALFTAGFALREVGAFDYTNINIYLASTLLIYMSPPILELANYHILGRTLYYVPYFSPIHPGRVLTTLGSLSAIVEILNALGLAVILLFYSLAALFHRRCARAGVAHPRVRAVLYTLYISMLLILARTIYRAVEHFAAPAVAGGQADAWRSLSPIIRYEWFFWVFEAAPMLVNALMWNARHPRRYLPQSYKVYLAQDGATEVHGPGWGDKRNVVMTLVDPFGFLAMCEKGRRGEPFWEGNGYHHLLGGKGAEGQVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PCX0</accession>
    <name>A0AAN6PCX0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_38426</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854455">
        <property type="protein sequence ID" value="KAK4035092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PCX0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025649">
        <property type="entry name" value="DUF4360"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38847">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38847:SF1">
        <property type="entry name" value="PSEUDOURIDINE SYNTHASE RSUA_RLUA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14273">
        <property type="entry name" value="DUF4360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043035799" description="Secreted protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4035092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="210" mass="22708" checksum="F3F9894240AEBE10" modified="2024-10-02" version="1">MQFSKIIALFAGLAVAAPAVTERDGPSGHEVEIRGFTYGGNGCPGGSVGSMLSTDLMTLTLIYDNFIAESGPGIKANEYRKTCQANVKLHCPQGWQFSVFKADYRGHATLPKDVSGSAKATYYFSGSSGQISSNKDFKGPVDEDYLKTDVFGVESTVWSPCGVEGLLNVKSAIQISPLDSNKKALLTSESTDLTFKQIHYLQWRKCTKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PCZ9</accession>
    <name>A0AAN6PCZ9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_38410</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854454">
        <property type="protein sequence ID" value="KAK4035137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PCZ9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17476">
        <property type="entry name" value="MFS_Amf1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF9">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="257"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="286"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="368"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="393"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="419"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="514"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="63"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4035137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="563" mass="60002" checksum="95DAC93DF0908637" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PD87</accession>
    <name>A0AAN6PD87_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Fungal-specific transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">C8A01DRAFT_49354</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the xlnR/xlr1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854489">
        <property type="protein sequence ID" value="KAK4034221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PD87"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000004">
        <property type="entry name" value="Xylanolytic transcriptional activator XlnR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051439">
        <property type="entry name" value="XlnR/Xlr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47663">
        <property type="entry name" value="XYLANOLYTIC TRANSCRIPTIONAL ACTIVATOR XLNR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47663:SF1">
        <property type="entry name" value="XYLANOLYTIC TRANSCRIPTIONAL ACTIVATOR XLNR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="10">
        <location>
            <begin position="94"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="58"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="132"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="553"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="732"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="139"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="162"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="755"/>
            <end position="769"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK4034221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="946" mass="102969" checksum="9744C763011894B6" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PDT2</accession>
    <name>A0AAN6PDT2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">chitinase</fullName>
            <ecNumber evidence="4">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">C8A01DRAFT_18712</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="4"/>
    <dbReference type="EMBL" id="MU854477">
        <property type="protein sequence ID" value="KAK4034506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PDT2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06548">
        <property type="entry name" value="GH18_chitinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.10:FF:000005">
        <property type="entry name" value="Endochitinase B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000075">
        <property type="entry name" value="Sporulation-specific chitinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF317">
        <property type="entry name" value="CHITINASE 12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="10 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 12 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042889388" description="chitinase" evidence="13">
        <location>
            <begin position="24"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="14">
        <location>
            <begin position="40"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK4034506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="424" mass="45556" checksum="40E870BEBA64C623" modified="2024-10-02" version="1">MAPWSLKRTALAVLSFCTALTQALPLPAEAEVHARQSSGYKNIVYFTNWGIYGRNYQPDQLPATQLSHVLYAFANLRSTGEVFLSDTYADTDKHYPGDSWNDIGTNVYGCAKQLFLLKKSHRQLKTLLSIGGWTYSPTFPAAASTPATRALFASSAVRLLADLGFDGLDIDWEYPANPNEAANFLLLLQAVRSALDAYAAQHAPGYRFLLTIASPAGPSNYAHLPLAEISRTIDFFNLMAYDYAGPWSAVSAHQANLFPVTPNATTPFSTDAAVSAYLAAGVPPAKIVLGMPIYGRSFANTAGLGQSYQGVGQGSWEQGVWDYKVLPRPGAEVVYDAVAGATYSYDAAAREMVSFDTVDMVVRKVGYLKGKGMGGSMFWEASADRVGEGSLMGASFGALGGVEQGGNLLSYPDSRYDNVRAGFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PDW7</accession>
    <name>A0AAN6PDW7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_18653</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854474">
        <property type="protein sequence ID" value="KAK4034566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PDW7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033063">
        <property type="term" value="C:Rad51B-Rad51C-Rad51D-XRCC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033065">
        <property type="term" value="C:Rad51C-XRCC3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000707">
        <property type="term" value="P:meiotic DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01393">
        <property type="entry name" value="RecA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052093">
        <property type="entry name" value="HR_Repair_Mediator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46239:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46239">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 3 RAD51C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="8">
        <location>
            <begin position="38"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="316"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="373"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="385"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4034566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="418" mass="44870" checksum="400D26C126C14304" modified="2024-10-02" version="1">MDYHAIHGHDVSSFDLPSTHRLPTVSAAQALQELEGDDSRFIPTRLAALDASLSPGLHGAELGGIQKGHVTEIWGPPGAGKTAFGIQLASHCLGERRGVVWVDGFHRVPIERLRAVIGKGTGEGEDADLGRLDGFTHYTCPTLPHLIALLCRPTASCIPQGTSLVVVDALSALVNHAFPKLPETRPVRDAKGSKGPSALARRLQVLQYIVSSLQKLAATRDLAVVLLTQCATMMQAERGATLAPAINAAVWEQGMSTRLVLFRDWLHEGSETRGLHFVAIQKLNGKGVGALLESVCAFKVDEGGLLPVEYDNTQQSRTLTSTPAPKRKLGDTDFEIADSDDEDYGWDDDEELPPMPSQWQGSEDLLLVRKPESDDEGDGDDEQPLEAHESEDQGPDGAKDASDEASRADRAESSGASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PF50</accession>
    <name>A0AAN6PF50_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA polymerase kappa</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_37245</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA polymerase type-Y family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854418">
        <property type="protein sequence ID" value="KAK4038835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PF50"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03586">
        <property type="entry name" value="PolY_Pol_IV_kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.810:FF:000001">
        <property type="entry name" value="DNA polymerase kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.810:FF:000003">
        <property type="entry name" value="DNA polymerase kappa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000014">
        <property type="entry name" value="DNA polymerase kappa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.100:FF:000010">
        <property type="entry name" value="DNA-directed polymerase kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000039">
        <property type="entry name" value="Polymerase (DNA directed) kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.60:FF:000012">
        <property type="entry name" value="Putative DNA-directed polymerase kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="entry name" value="DNA polymerase, Y-family, little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050116">
        <property type="entry name" value="DNA_polymerase-Y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022880">
        <property type="entry name" value="DNApol_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024728">
        <property type="entry name" value="PolY_HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002677">
        <property type="entry name" value="PRK02406.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11076:SF33">
        <property type="entry name" value="DNA POLYMERASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11076">
        <property type="entry name" value="DNA REPAIR POLYMERASE UMUC / TRANSFERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11798">
        <property type="entry name" value="IMS_HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="Lesion bypass DNA polymerase (Y-family), little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UmuC" evidence="6">
        <location>
            <begin position="120"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="471"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="572"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="573"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4038835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="615" mass="68394" checksum="BAEBF0697912DC9A" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PFP2</accession>
    <name>A0AAN6PFP2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Folylpolyglutamate synthase</fullName>
            <ecNumber evidence="17">6.3.2.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Folylpoly-gamma-glutamate synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Tetrahydrofolylpolyglutamate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">C8A01DRAFT_48005</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 17">
            <text>(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + L-glutamate + ATP = (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10580"/>
            <dbReference type="Rhea" id="RHEA-COMP:14738"/>
            <dbReference type="Rhea" id="RHEA-COMP:14740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:141005"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>a monovalent cation</name>
            <dbReference type="ChEBI" id="CHEBI:60242"/>
        </cofactor>
        <text evidence="17">A monovalent cation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 17">Cofactor biosynthesis; tetrahydrofolylpolyglutamate biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 17">Belongs to the folylpolyglutamate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.17" evidence="17"/>
    <dbReference type="EMBL" id="MU854431">
        <property type="protein sequence ID" value="KAK4038371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PFP2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1190.10:FF:000009">
        <property type="entry name" value="Folylpolyglutamate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.20:FF:000031">
        <property type="entry name" value="Folylpolyglutamate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="entry name" value="Mur ligase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="entry name" value="Mur-like, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001645">
        <property type="entry name" value="Folylpolyglutamate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018109">
        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023600">
        <property type="entry name" value="Folylpolyglutamate_synth_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01499">
        <property type="entry name" value="folC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136:SF5">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038895">
        <property type="entry name" value="FPGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="MurD-like peptide ligases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="MurD-like peptide ligases, peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01011">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01012">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 17 20" id="KW-0436">Ligase</keyword>
    <keyword evidence="13 19" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 17" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="19">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRNR" id="PIRNR038895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR038895-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR038895-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAK4038371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="488" mass="53326" checksum="BBD58CCE0FAAAD4B" modified="2024-10-02" version="1">MATRTYNDAIDALNSLQTPYAVIEARRRAGIRPDAASVREMRAYLARVGYAPRDLDRLNIVHVAGTKGKGSTCAFVDSILSRYQQRTNKPHKVGLFTSPHLIAVRERIRIGSAPLSEELFARYFFEVWDRLEANRDVAADAAAPGSKPIYARYLTLMSYHVFLSEGVDAAVYETGIGGEFDATNVVERPVASGISTLGIDHVFVLGDTVDKIAWHKAGIMKPGSPAFTIEQVPAAAEVLKKRAVEKKVDLKVLDIDPRLAGVNIRPDATFQKKNATLGVALAEAALQKLDPSFSPNPEALPQEFVDGLEQVIWRGRCEVKDEDSVIWHVDGAHTVDSLKMAARWFVGECAGRAEGGPKVLIFNQQGRTEAVDFLDGLCNTVKNSGRGFEHVIFCTNVTYAATGYKRDFVNHQHNPADIEKMTQQRVFADRWKQLDPSANVLLIPSIEEAINTARGLAEDDGPKVQALITGSLHLVGGALGILEGADAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PFX5</accession>
    <name>A0AAN6PFX5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ornithine decarboxylase antizyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_16185</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimer, and targets the monomers for ubiquitin-independent proteolytic destruction by the 26S proteasome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with ODC and thereby sterically blocks ODC homodimerization.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ODC antizyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854389">
        <property type="protein sequence ID" value="KAK4039882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PFX5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008073">
        <property type="term" value="F:ornithine decarboxylase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045732">
        <property type="term" value="P:positive regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0075523">
        <property type="term" value="P:viral translational frameshifting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002993">
        <property type="entry name" value="ODC_AZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038581">
        <property type="entry name" value="ODC_AZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10279">
        <property type="entry name" value="ORNITHINE DECARBOXYLASE ANTIZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10279:SF10">
        <property type="entry name" value="ORNITHINE DECARBOXYLASE ANTIZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02100">
        <property type="entry name" value="ODC_AZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0688">Ribosomal frameshifting</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="65"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="146"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="146"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4039882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="316" mass="34344" checksum="FC46E5D08C53C75B" modified="2024-10-02" version="1">MAPMKSPKSNHSSSNYGEDFARQANILASCYIGPSGIPEVPSTGLPSPPSSPPLAALTTTNQLALTPKARSSSTRAHGVGRHGPGTATDTNSSAWHRRRGGATLRIREECERFFCEPLRAMLLGERNVALQGSGLASVYNDNHNYNSNDNNSYNNSISNNASRNDGRAQAVGHHGQLTPPDDFPIADETMMGRRRLGARGGVLGWLEIWDYAGGSSFRGFVAEDATRETKSLFVFFDAHSITRDLKQALVALIELAEGPLACSHMVICIERSIPEEETKGLTKGLQWAGFSLTTLDFWSPGFDVVSNRWLFMGMEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PFY0</accession>
    <name>A0AAN6PFY0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pantoate--beta-alanine ligase</fullName>
            <ecNumber evidence="3">6.3.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Pantoate-activating enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Pantothenate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">C8A01DRAFT_35732</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(R)-pantoate + beta-alanine + ATP = (R)-pantothenate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10912"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:29032"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57966"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pantothenate synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.1" evidence="3"/>
    <dbReference type="EMBL" id="MU854381">
        <property type="protein sequence ID" value="KAK4040218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PFY0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004592">
        <property type="term" value="F:pantoate-beta-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00560">
        <property type="entry name" value="PanC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1300.10:FF:000002">
        <property type="entry name" value="Pantoate--beta-alanine ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000013">
        <property type="entry name" value="Pantothenate synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1300.10">
        <property type="entry name" value="Pantoate-beta-alanine ligase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00158">
        <property type="entry name" value="PanC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003721">
        <property type="entry name" value="Pantoate_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042176">
        <property type="entry name" value="Pantoate_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00018">
        <property type="entry name" value="panC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21299">
        <property type="entry name" value="CYTIDYLATE KINASE/PANTOATE-BETA-ALANINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21299:SF1">
        <property type="entry name" value="PANTOATE--BETA-ALANINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02569">
        <property type="entry name" value="Pantoate_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK4040218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="355" mass="38921" checksum="A4BC17D28EB738F9" modified="2024-10-02" version="1">MATRCSTSPSRANGPEKLPSSSIRVLRTVSNLRRWRRQHLLDQRSVALVPTMGALHEGHLSLIRAAARENHHVVVSIYVNPAQFGVNEDLSSYPRTWDTDTAALVKLDRELADDGHNLGRISAVFAPSTDEMYPAGFPGQEPASKGSFVTITPVGELLEGKSRPTFFRGVATVCMKLFNIVQPERVYFGQKDVQQTVVIRRLVRDFMLPIEVVVGPTTRAADGLALSSRNVYLGDRRRAVAPVLYNALRAAEEVYKGGARDRETVLGAAQRFVKDALAEQMLLVPGKRVLFEIDYISLADPETMEELEVVDPAKGGILSGALKMLVLEALDAEDRGDNGGPGVRLIDNIILQPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PG25</accession>
    <name>A0AAN6PG25_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_47139</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854402">
        <property type="protein sequence ID" value="KAK4039345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PG25"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4039345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="453" mass="52945" checksum="862E4E23FC80159A" modified="2024-10-02" version="1">MSDSEAAISKPLLSVRDILAFEDAELAEYMQRHRGPDGGFDLDDIERWDALPEDQRDKLAERLKFGAQQADEAMHSCPISAGQDAASQPLSRPSRFDRSPTVEVDPNEEIEQAKRFETAAYQDLINDGGQPAYPINLLEKVSEDPEPYREVLLPWQEYPDKGSLQWQEVFHRQFRRWQDFRAWQQDNRGIVNDEAGFLAFVDANDKAYAILGTTWQKMWPRETESRHRESLKEQWECQENKRKADHYWLRGGCKHTTFSEYADDQVQHRLARHGFTLTFKLPDDSTQQDQLTTWIEYLNFEYSWLDRYARLIEMRRREDIKAWQKLMDSGVLRRHETIDFLSITESQIQRQAELNKATSAVASAENAARSALGETEKAKHGRSRYSVQERVKRLAEAQSRLTAAKDSLKEVNERLHLIATFIWGQGPYWTAKRDLLRHELLVQWILDQRSSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PG53</accession>
    <name>A0AAN6PG53_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">C8A01DRAFT_17340</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854424">
        <property type="protein sequence ID" value="KAK4038611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PG53"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000489">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000196">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000012">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF199">
        <property type="entry name" value="MFS EFFLUX TRANSPORTER INPD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="84"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="175"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="235"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="349"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="390"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="416"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="440"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="479"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="548"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="85"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK4038611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="585" mass="62676" checksum="EFCCF7912E3BFCB0" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PGD5</accession>
    <name>A0AAN6PGD5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like-conjugating enzyme ATG10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Autophagy-related protein 10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_47697</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATG10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854420">
        <property type="protein sequence ID" value="KAK4038746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PGD5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061651">
        <property type="term" value="F:Atg12 conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032446">
        <property type="term" value="P:protein modification by small protein conjugation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1460.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007135">
        <property type="entry name" value="Atg3/Atg10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14957">
        <property type="entry name" value="UBIQUITIN-LIKE-CONJUGATING ENZYME ATG10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14957:SF1">
        <property type="entry name" value="UBIQUITIN-LIKE-CONJUGATING ENZYME ATG10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03987">
        <property type="entry name" value="Autophagy_act_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0072">Autophagy</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="335"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4038746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="358" mass="40252" checksum="9A11B5D30DEC9804" modified="2024-10-02" version="1">MTVASLRRAAAAGRQIYIHPKPTTLPHAQNNLRAFSDEAATRPQPKGFIPISKPQIVDCLGWTEFKGSDINTQLERARVAEESKADDEMYPAIVYRFVAEEGIPEVDSILSQVDFLHLAGFVSVSFNENNWLGKGLLVDFSDIVSYHTGPMWWRHSYYAEQFAEVCHHLDRRYCQATLGPVRRQWKLRVCMALNTSAAFTLGPEYSTYLQIIRPLEGELYDGDLSRCLDGFSFDPFQTGYGHVRYEIHLHPTYQAPCLWFSLHDLPADEQPLDIDTVFRRLVPEQFKQGLRGSVGGIGGISVDHHPVTGVPSFFIHPCLLGEAMEKFDCSKENYLMVWLGLVGGCVGLWVPAGMALKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PGK9</accession>
    <name>A0AAN6PGK9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleolar protein 58</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">C8A01DRAFT_35681</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for pre-18S rRNA processing. May bind microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP5/NOP56 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854379">
        <property type="protein sequence ID" value="KAK4040352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PGK9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.90:FF:000003">
        <property type="entry name" value="Nucleolar protein 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.4070:FF:000001">
        <property type="entry name" value="Probable Nucleolar protein 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.90">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045056">
        <property type="entry name" value="Nop56/Nop58"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012974">
        <property type="entry name" value="NOP58/56_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042239">
        <property type="entry name" value="Nop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002687">
        <property type="entry name" value="Nop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036070">
        <property type="entry name" value="Nop_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012976">
        <property type="entry name" value="NOSIC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894">
        <property type="entry name" value="NUCLEOLAR PROTEIN 5 NUCLEOLAR PROTEIN NOP5 NOP58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894:SF1">
        <property type="entry name" value="NUCLEOLAR PROTEIN 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01798">
        <property type="entry name" value="Nop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08156">
        <property type="entry name" value="NOP5NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00931">
        <property type="entry name" value="NOSIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89124">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51358">
        <property type="entry name" value="NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Nop" evidence="10">
        <location>
            <begin position="285"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="471"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="538"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="471"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="486"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="496"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="554"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="582"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="596"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK4040352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="605" mass="66748" checksum="8B70F4F3E176434C" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PGN7</accession>
    <name>A0AAN6PGN7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_15480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854372">
        <property type="protein sequence ID" value="KAK4040659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PGN7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF9">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4040659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="292" mass="31490" checksum="F8E4379A5F676AA6" modified="2024-10-02" version="1">MLGNRALTRNQQVIETCRRSAKTTVDRDTILAARCSAIQGLHSMLAQPDTSTSDGAIGAVVNLVMNDICFGEVRELRVHVEGAREMVRARGGLAALEAKGNLAKMLLIPPAPIPTLNPTTTAIFKDTDFLLDAVLALPPEPSAWQLHKVQTMSEWVQGRLSGASAKKTTSPSSTSANLHRAVRLSSLLYCRAIQARQPFSQAIPENDVLELAEAVWAVPLETWDAMPWTLVSVLAVGLPTARSIPQCGSARMMLVTAAVQLALRDWGAVMRVMGRVVRLQAWLRGPRGGVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PH08</accession>
    <name>A0AAN6PH08_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_15553</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854373">
        <property type="protein sequence ID" value="KAK4040592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PH08"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4040592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="152" mass="16816" checksum="247DDF1248B11EDB" modified="2024-10-02" version="1" fragment="single">FGDFRVFFVPVDDGQLHTYRIDTFLAPLLMQDPPLPLTRTLYLAENRTIDPPSPRLLVVHRAIAQILHLSAAGQYIDRILRDAEEHGIQADGSTELGRLVRLGLGALAWAPGRMVSVSVRNNSNGSSSSLLPFPSFISLPLLNITVQPWFVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PHD9</accession>
    <name>A0AAN6PHD9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_37484</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854425">
        <property type="protein sequence ID" value="KAK4038575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PHD9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40619">
        <property type="entry name" value="FUNGAL STAND N-TERMINAL GOODBYE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40619:SF3">
        <property type="entry name" value="FUNGAL STAND N-TERMINAL GOODBYE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="627"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="635"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4038575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="647" mass="69896" checksum="F99299362F16F74B" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PHW5</accession>
    <name>A0AAN6PHW5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Septin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_15728</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854378">
        <property type="protein sequence ID" value="KAK4040393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PHW5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032156">
        <property type="term" value="C:septin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000328">
        <property type="entry name" value="Septin spn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="5">
        <location>
            <begin position="16"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="362"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4040393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="385" mass="43632" checksum="427CDF4EB04EF86A" modified="2024-10-02" version="1">MFTTQKMIRRKKNVKKGIQFCLMVCGASGTGRTTFVNTLCGQPVLSHKESDDSSTAHVEEGVKIKPVTVELELDEEGTRISLTIVDTPGFGDQIDNEASFSEIVGYLERQYDDILAEESRIKRNPRFRDNRVHAMLYFITPTGHGLRELDIELMKRLAPRVNVIPVIGRADSLTPSELAESKKLVMEDIEHYRIPVYNFPYDIEEDDEDTVEENAELRGLMPFAIVGSEDVVEIGGRQVRARQYPWGVVEVDNPRHSDFLAIRSALLHSHLADLKEITHDFLYENYRTEKLSKSVEGGAGVDSSMNPEDLASQSVRLKEEQLRREEEKLREIEVKVQREINEKRQELLARESQLREIEARMQREAAANAAAQQAAAANHEANGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PIN5</accession>
    <name>A0AAN6PIN5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">von Willebrand factor type A domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_45856</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854368">
        <property type="protein sequence ID" value="KAK4040828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PIN5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013694">
        <property type="entry name" value="VIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45737:SF4">
        <property type="entry name" value="VON WILLEBRAND DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_4G01160)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45737">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08487">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13768">
        <property type="entry name" value="VWA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00609">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51468">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VIT" evidence="2">
        <location>
            <begin position="73"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="365"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4040828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="744" mass="81723" checksum="A111A49DACD7B75C" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PJ95</accession>
    <name>A0AAN6PJ95_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_14409</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854349">
        <property type="protein sequence ID" value="KAK4041906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PJ95"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF42">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="255"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="42"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="366"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4041906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="392" mass="43428" checksum="05B710BE295E6761" modified="2024-10-02" version="1">MASTPAPPTPEELAALPHDNHATELLASIWSLFFVATVFLCLRIYCRLLKRRSLWWDDVILLASWVCVAIDSALLSYMATLGYGRHAWDLDQGTIESLLLLSTISGTFSILGAVWSKTSFGVTLLQITEGWYNVLTWFCIVSMNIAMILSAIFLWTMCTPVRKAWDFDIEGTCWDPKVNIYYSTFSGSYSGLMDFALALLPWRYLWDLQMKRKEKLGVGFAMSMGVFAGATAIVKASKIPLMLSSDIAEGIPLSIWGHAEVCASIIAASIPMLRVLVRDAKSSRNYHSSYYDGNGTGMLSGNQHGRNHSRLVTITSKAAPPSDHELHELHKLSDDRSDRGILVLGDDGERLQAQHGIVQVTDFTVKYDESGEGSDGRSEGRSEGRSEGRRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PJB2</accession>
    <name>A0AAN6PJB2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_16462</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854397">
        <property type="protein sequence ID" value="KAK4039580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PJB2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4039580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="116" mass="13546" checksum="C2AB9FB511822A12" modified="2024-10-02" version="1" fragment="single">ALGPMPDEWWERWEGKSKRFIGNGKPKEGRDVWTFDQRFEDAIQAPRRRRGTEGMDDEERDALFEMVRGMLIFKPGDRLSASQVLTTEWMRKWAIPEAEKSWARKVLCNGRSSGNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PJE5</accession>
    <name>A0AAN6PJE5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Enolase C-terminal domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_36408</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854396">
        <property type="protein sequence ID" value="KAK4039625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PJE5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009063">
        <property type="term" value="P:amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="entry name" value="Enolase-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="entry name" value="Enolase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018110">
        <property type="entry name" value="Mandel_Rmase/mucon_lact_enz_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046945">
        <property type="entry name" value="RHMD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13794">
        <property type="entry name" value="ENOLASE SUPERFAMILY, MANDELATE RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13794:SF58">
        <property type="entry name" value="MITOCHONDRIAL ENOLASE SUPERFAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00001">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00179">
        <property type="entry name" value="mandelate_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="Enolase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="Enolase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00909">
        <property type="entry name" value="MR_MLE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mandelate racemase/muconate lactonizing enzyme C-terminal" evidence="4">
        <location>
            <begin position="209"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4039625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="459" mass="50723" checksum="59DE71874D86E441" modified="2024-10-02" version="1">MGSLSDITVDNVEIIGFEITDLRFPTSLDGVGSDAMHVGTNGSHPYVRLLTNYPGLVGEGIAFSNGRGSELITLALSIFAQRVVSKRMSQLTRDMGKTWRYMVSDSQYRWIGPEKSVTHLAVAGVLNGVWDLWGKILGKPVWRIVCDMSPEEVVRCIDFRYITDVVTPDEAVAMLRRTQEGKGDRLKEALGNKAVPAYTTSPGWLAFSGERMREVLEETIAQGFTVFKFKVGTSVEADRERLSAVREVLGYDRGYQIMIDANQVWSVPEAIEYMKHLVEFKPVFIEEPTNPDDVLGHAAIRKALKPYGVGVATGEAAQNRVTFKQLLQAEATDVAQIDAVRLGSVNECLAVMLMALKFGVPCVPHNGAMGLTELTSHLSLIDYVAVSGRRSMLEFADSHRENLRHPSKIVDAHYVTPLEPGYSIGYTKEALEKYTYPTGSFWRSEVGLQIIAQPTGGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PJJ1</accession>
    <name>A0AAN6PJJ1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">TPR-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_46870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854394">
        <property type="protein sequence ID" value="KAK4039685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PJJ1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039340">
        <property type="entry name" value="Tfc4/TFIIIC-102/Sfc4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23082:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23082">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIIC TFIIIC , POLYPEPTIDE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="834"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="56"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="517"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="803"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="535"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="807"/>
            <end position="819"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4039685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="997" mass="113774" checksum="B754AA6BB31B8B03" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PJJ6</accession>
    <name>A0AAN6PJJ6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial</fullName>
            <shortName evidence="5">Glu-AdT subunit A</shortName>
            <ecNumber evidence="5">6.3.5.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_14218</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-glutamyl-tRNA(Gln) + L-glutamine + ATP + H2O = L-glutaminyl-tRNA(Gln) + L-glutamate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A, B and C subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the amidase family. GatA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.7" evidence="5"/>
    <dbReference type="EMBL" id="MU854345">
        <property type="protein sequence ID" value="KAK4042168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PJJ6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030956">
        <property type="term" value="C:glutamyl-tRNA(Gln) amidotransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070681">
        <property type="term" value="P:glutaminyl-tRNAGln biosynthesis via transamidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT A, MITOCHONDRIAL"/>
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    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
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        <location>
            <begin position="47"/>
            <end position="523"/>
        </location>
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        <location>
            <begin position="103"/>
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        </location>
    </feature>
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        <location>
            <begin position="136"/>
            <end position="149"/>
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    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="50"/>
        </location>
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    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="157"/>
        </location>
    </feature>
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        <location>
            <position position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03150"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK4042168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="540" mass="57564" checksum="DDB2F816E73D1B68" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PJV7</accession>
    <name>A0AAN6PJV7_9PEZI</name>
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        <recommendedName>
            <fullName evidence="12">C2H2-type transcription factor MSN2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">C8A01DRAFT_14238</name>
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    <organism evidence="16 17">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 284.82</strain>
        </source>
    </reference>
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        <subcellularLocation>
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        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="C2H2 zinc finger protein"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="VerF-like"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
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        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF11">
        <property type="entry name" value="ZINC FINGER PROTEIN YPR022C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
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    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
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    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0843">Virulence</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="447"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="476"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="351"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="554"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="378"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="396"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="412"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="569"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00093629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK4042122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="580" mass="61371" checksum="C6434C67072B7E7A" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PKL1</accession>
    <name>A0AAN6PKL1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Switch 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_13705</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
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            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAK4042708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP001303115">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000019">
        <property type="entry name" value="DNA excision repair protein ERCC-6-like 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029256">
        <property type="entry name" value="Heliccase-ass-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057931">
        <property type="entry name" value="RHH_ERCC6L2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050496">
        <property type="entry name" value="SNF2_RAD54_helicase_repair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629:SF7">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629">
        <property type="entry name" value="SNF2/RAD54 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25806">
        <property type="entry name" value="RHH_ERCC6L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14773">
        <property type="entry name" value="VIGSSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="186"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="556"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="765"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="959"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="39"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="78"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="970"/>
            <end position="979"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4042708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1041" mass="117144" checksum="D5694FBF500C1243" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PKL5</accession>
    <name>A0AAN6PKL5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein phosphatase 2A activator</fullName>
            <ecNumber evidence="8">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Phosphotyrosyl phosphatase activator</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_44551</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for PP2A-like phosphatases modulating their activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2Ai) in presence of ATP and Mg(2+) by dissociating the inactive form from the complex.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the PTPA-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="8"/>
    <dbReference type="EMBL" id="MU854341">
        <property type="protein sequence ID" value="KAK4042417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PKL5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008160">
        <property type="term" value="F:protein tyrosine phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04087">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1150:FF:000002">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004327">
        <property type="entry name" value="Phstyr_phstse_ac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043170">
        <property type="entry name" value="PTPA_C_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037218">
        <property type="entry name" value="PTPA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012:SF5">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A ACTIVATOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03095">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016325">
        <property type="entry name" value="Phstyr_phstse_ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140984">
        <property type="entry name" value="PTPA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0697">Rotamase</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="376"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="50"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="385"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4042417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="449" mass="49628" checksum="6664076B0325D485" modified="2024-10-02" version="1">MASTSPTVPQEGTKSPAPAHPPPKPSGGIPNLKDRIPKLEPRRRKAEPANPVPIPETPPAPPRPDPATLNFTVPARRILSPKDHQLFLSSPTYTLILSFIFGLSESVVDRPISSVKDTDLSPTVQSILAILDETESLCLDSPPDDQGGSRFGNKTFRVFLDKVKQRAPAWHATLLKDKIPNPTAAASELSTYLCQSFGNRSRIDYGSGHELNFAMWLLCLSQLSLLQPARDSPALVLRVFARYLSVMRRVQSTYYLEPAGSHGVWGLDDYQFLPFLFGASQLAHHAFVTPRAIHQELALEEFGDDFLYLGQVAFVNSTKTVKGLRWHSPMLDDISSARSWGKIEGGMRRMFVSEVLGKLPVMQHFLFGSLIPAAEGMSEPREKDGEEEEEEEGEGGEVEVFDDKEGVRHVHQPSGWGDCCGIKVPSSIAAAEEMRKRGVGEQLRRIPFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PKT1</accession>
    <name>A0AAN6PKT1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_33465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854340">
        <property type="protein sequence ID" value="KAK4042522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PKT1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="305"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="336"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4042522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="396" mass="42193" checksum="0FFC6CFD8B39F586" modified="2024-10-02" version="1">MPHFEAWYPQFGSRLNAIMLANCSEQLQYYRMSDPPYSCRGCKAASVQTCLPDSAPGWMKANMAIGVGCLAEAVETCILANAPEWMKSNMGAAGVLLGLLPTILSLAGPDTAETGLLAQRRPFLASLIALGSPAVSPYRMFMASDPAELLLSDKKSGTGSLMDIQNLGFMQKLGILAAQYLLAAAAVVGVFHNSWTLGVQTLCSFSTESTYHPLLWAATALLANTVSAIATLLRIAITEHQHEHGHRPGPPVVLSSSPPPVTYYTLLPAKLQRMLQREFQLSGAPSHTTTSIIITRKPNSYPAAIAAWLTSTGTILHIIYGTITFSTVVFISTQDALGVVARYLVSTLVCRIILNFELSGMRAVVRGDGEGEGDGQGTAVVVGARPGQMLKAQTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PLG9</accession>
    <name>A0AAN6PLG9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription factor SWI6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">C8A01DRAFT_15496</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Transcription factor that plays a role downstream of the MCK1-MKK2-MPS1 cascade. Required for hyphal morphogenesis and pathogenicity. Is an important oxidative stress response regulator and plays a positive role in the regulation of extracellular peroxidases.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854372">
        <property type="protein sequence ID" value="KAK4040690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PLG9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030907">
        <property type="term" value="C:MBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033309">
        <property type="term" value="C:SBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048315">
        <property type="term" value="P:conidium formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.260.10:FF:000001">
        <property type="entry name" value="APSES transcription factor (MbpA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000365">
        <property type="entry name" value="Start control protein cdc10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.260.10">
        <property type="entry name" value="Transcription regulator HTH, APSES-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036887">
        <property type="entry name" value="HTH_APSES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018004">
        <property type="entry name" value="KilA/APSES_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051642">
        <property type="entry name" value="SWI6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003163">
        <property type="entry name" value="Tscrpt_reg_HTH_APSES-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828">
        <property type="entry name" value="ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828:SF3">
        <property type="entry name" value="CHROMO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04383">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01252">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54616">
        <property type="entry name" value="DNA-binding domain of Mlu1-box binding protein MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51299">
        <property type="entry name" value="HTH_APSES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 9" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0183">Conidiation</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0749">Sporulation</keyword>
    <feature type="domain" description="HTH APSES-type" evidence="12">
        <location>
            <begin position="13"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="9">
        <location>
            <begin position="350"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="9">
        <location>
            <begin position="490"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="171"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="531"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="598"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="222"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="536"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00059984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00073460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK4040690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="786" mass="86439" checksum="7B74FD9009056D98" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PLQ5</accession>
    <name>A0AAN6PLQ5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tryptophan--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Tryptophanyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">C8A01DRAFT_44000</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="3"/>
    <dbReference type="EMBL" id="MU854332">
        <property type="protein sequence ID" value="KAK4043077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PLQ5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006436">
        <property type="term" value="P:tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00806">
        <property type="entry name" value="TrpRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.240.10:FF:000003">
        <property type="entry name" value="Tryptophan--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000033">
        <property type="entry name" value="tryptophan--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10055:SF1">
        <property type="entry name" value="TRYPTOPHAN--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10055">
        <property type="entry name" value="TRYPTOPHANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="450"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK4043077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="485" mass="54330" checksum="EED45EE6FB410587" modified="2024-10-02" version="1">MATNVNAAALDESPVPEPAQKQHKQTVDPYNVSGEVGEDGVVKAIDYNKLVDEFGTKKIDDALLARFERVTGKRPHHFLRRGIVFSHRDFEFILDRYERGEPFFLYTGRGPSSDSVHVGHTIPFEFTKWLQDTFDVPLIIMLTDDEKYLFSEKRTIEEVQGYCSSNAKDIIAIGFDPAKTFIFSDFDYVGGAFYRNIVRLSKHITLNQARAIFGFNESSNIGRIHFGSIQGATSWASSFPHIFGEDETKTVGIPALIPCAIDQDPYFRMTRDVSARLKYQGKPYAKPSLIHALFLPALQGPGTKMSASIDESAIFMKDTPNQIKNKINKYAFSGGKVSVEEHRELGGDTSVDVSFQYLRFFLDDDDELEKIRVSYEKGELLTGELKAICIKELQKYVAGFQERRAKVDDAAVAVFMERRPLKWGGNPRAPIVVPQVENGDASEAAAEGDGKMTKNQLKKLQKMKQAEEKKAQKALEKAEAAVKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PM18</accession>
    <name>A0AAN6PM18_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Zinc transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_15219</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854366">
        <property type="protein sequence ID" value="KAK4040975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PM18"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF44">
        <property type="entry name" value="PROTEIN ZNTC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042909394" description="Zinc transporter" evidence="7">
        <location>
            <begin position="25"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="312"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="389"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="498"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="528"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="571"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="423"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="443"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4040975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="592" mass="61719" checksum="CDEF84A054D579C0" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PMT2</accession>
    <name>A0AAN6PMT2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Kelch repeat-containing protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_43405</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854325">
        <property type="protein sequence ID" value="KAK4043647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PMT2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.10">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025183">
        <property type="entry name" value="DUF4110"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052588">
        <property type="entry name" value="Kelch_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013536">
        <property type="entry name" value="WLM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46063">
        <property type="entry name" value="KELCH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46063:SF1">
        <property type="entry name" value="KELCH DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13422">
        <property type="entry name" value="DUF4110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08325">
        <property type="entry name" value="WLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51397">
        <property type="entry name" value="WLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="WLM" evidence="5">
        <location>
            <begin position="714"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="306"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="392"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="435"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="547"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="945"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1019"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="393"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="437"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="451"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="563"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="594"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="947"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="957"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1039"/>
            <end position="1081"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4043647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1155" mass="127433" checksum="53952E411E69D25B" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PNJ2</accession>
    <name>A0AAN6PNJ2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_44879</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854346">
        <property type="protein sequence ID" value="KAK4042106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PNJ2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037830">
        <property type="entry name" value="ZZZ3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22705">
        <property type="entry name" value="ZINC FINGER, ZZ DOMAIN CONTAINING 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22705:SF0">
        <property type="entry name" value="ZZ-TYPE ZINC FINGER-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4042106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="361" mass="37949" checksum="D9F115B664371F67" modified="2024-10-02" version="1">MPGLTITTDLRPASATTSPVILNPRRASVSSRTSSPSRPPISPITPTLESAELPGPGQTSPALTTTHSTMPDFAFGRPIFTHTTQTDQVGVAPPPAQPIDFDSNPDVLALKSAISILQLQRARATADIQSLSRARDAALANPDAFTADLAAGRVRVDGDRLFSGTRAAGDLAEDDPDSDSTSDSESDFDKDDDEVQKEEEEGSTRQQVTPESEPKTDGGGATPPTNGAEPPPRKSKKKKHKGKQNPADNTAATTTTTTQPPPWQRLPKPQSVVRCPPVNWAQYGVVGDSLDKLHAEQVAAPTPGAPMVLGQGGTYEFKAGGSEQAGAATGGEQPRRLVGVAAPYNPMRDKVEKKGKGGSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PNJ4</accession>
    <name>A0AAN6PNJ4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_34149</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854351">
        <property type="protein sequence ID" value="KAK4041770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PNJ4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050817">
        <property type="entry name" value="DjlA_DnaK_co-chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24074">
        <property type="entry name" value="CO-CHAPERONE PROTEIN DJLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042883236" description="J domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="4">
        <location>
            <begin position="76"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="282"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4041770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="366" mass="40671" checksum="AF9589F1579381EF" modified="2024-10-02" version="1">MSALLSLLGWSFLPGLVTGWTQSLYYSITIRAGDPKPQPGSPRWAEHRRRIHILVITLYLLYTIYEADYDLQRAGTFYTDLGVPLNATDREIKSRFRRLAALHHPDKAGSGGRTQDDINAYFVHLKTAADALTNPAQRFAYERFGPGIVSWARCVTIRDFVVRGAQALVPYYGAAAVAMYALGLLGYLDWGRYERWLVLAALFVFEAHTVTRPGMPRVLGRVVNPVLGLVLGRAPYLPFQAIALARKLSVTVYIAFSQIGPLLAADTRSGQLVVGGAAGDDEKALREGLERLEMTVKRLDADATRLLETEMAPFAGDEETRNSMWAKVKEWLVQNTIRSDPMVRDALGRSFAKRRMDAPAGARGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PPR5</accession>
    <name>A0AAN6PPR5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein phosphatase 2C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_14041</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854342">
        <property type="protein sequence ID" value="KAK4042370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PPR5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004741">
        <property type="term" value="F:[pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF792">
        <property type="entry name" value="GM14286P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="111"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4042370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="487" mass="53413" checksum="4E6EA5FF23CBD284" modified="2024-10-02" version="1">MRPLCNALPRPGRGIQLQPDKFYRYYTRASYSTSPTNGKTTTRRAALVGGVASASVGFFWWATTTRRDQVPQLDRPPAAHLAVEPGPSEASVSRILSQGAYSFPVRGVPGISRYDGAQVASNSPCEDRFIHGRFFSPRGDGSQWMAWAVLDGHAGWQTADLLEKQLLPFVRYGLGQAKAAMDEGSAAVEAVQRAVTRAFVSLDDSIIKTALDTSQGAEPLQDKVRRLTPAYAGSCALLSIYDPASSTLHVACTGDSRAVLGRKRLDGTWEAVALSVDQTGRNTDEVARLSREHPGEENIAKDGRVLGIAVYRAFGDGRWKWPLELQQDLWRRFHGPAPLTPKYDVRTPPYLTAEPVMTATKIDPGKPTFLIMATDGMWDRLSNQQAVELVGKWLESNGPDKGGTNPDSGRGQLDFSQLRNVVNPRFIEGRTTIQDDNAAVHLVRNSLGGNHHELVAARLAFDAPFSRRLRDDVTVQVVFFVNNKDAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PPW1</accession>
    <name>A0AAN6PPW1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pyridine nucleotide-disulfide oxidoreductase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_13969</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854341">
        <property type="protein sequence ID" value="KAK4042430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PPW1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014839">
        <property type="entry name" value="Crt10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08728">
        <property type="entry name" value="CRT10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4042430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="755" mass="84149" checksum="2407163F91CD9F3A" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PQG2</accession>
    <name>A0AAN6PQG2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_31696</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854321">
        <property type="protein sequence ID" value="KAK4044098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PQG2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4044098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="204" mass="23584" checksum="BB7227C118310F91" modified="2024-10-02" version="1">MTSLAHRVRRPAPAGLKIPPAESKTPTALKDTPALEQAPSSPAVSVRKRRRPTFTSLPPEIHLLVTEHLIYPDALSLKHTNRYFYQLVDTGVELKVEWLMERRLLHLECPSDQRCDLGSDLRFCRGSVKLLMQRRREHIECESRPGLGCLIYGTSTCPHARKLKTRVKKWMRLHAVDRTRWALFLVWLVPLFIGWVWMVGVMML</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PQG9</accession>
    <name>A0AAN6PQG9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amino acid permease-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_42780</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854319">
        <property type="protein sequence ID" value="KAK4044340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PQG9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000042">
        <property type="entry name" value="Similar to amino acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF402">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="269"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="332"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="369"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="412"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="482"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="512"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="542"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="568"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="82"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4044340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="929" mass="99273" checksum="12B7CB165F9A800A" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PQN7</accession>
    <name>A0AAN6PQN7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PITH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_42870</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854319">
        <property type="protein sequence ID" value="KAK4044445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PQN7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.470">
        <property type="entry name" value="PITH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010400">
        <property type="entry name" value="PITH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037047">
        <property type="entry name" value="PITH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46115">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06201">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51532">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="3"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="PITH" evidence="4">
        <location>
            <begin position="134"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4044445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="331" mass="36043" checksum="C9770E7BE5745934" modified="2024-10-02" version="1">MSKTVNISSPSQFTEVLQGSVLVLANFYADSSIPSQQVAPVFEQLSQALSRPKLVTFVKVNTAQQKDIAEAYRVTSPPTFIIFRGGKVVEKVQGADALKLQSAVKKVSEEVQKMGSGEGGASGSGSGSNDANWKGAGLPRGYTDITSQVELRYCELLNVDPDAGSVRALFDTAKPSALSGGKGAAKDWVESDTDEQLLLFLPFQSMLKLHTLQITSLPPNDDDDDDEEVPMRPRTIKLFTNKPHNLGFDEAEDLSATQEFELSEEDWNAEGTANIPLRFVKFQNITSLVLFVVNGDGDGEKTRLDRLRLIGETGEKREMGKLEKIGDEPGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PQS0</accession>
    <name>A0AAN6PQS0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_42687</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854318">
        <property type="protein sequence ID" value="KAK4044505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PQS0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="400"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="331"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4044505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="486" mass="50269" checksum="263633A594F2A06B" modified="2024-10-02" version="1">MAPSDTQRARQTAQRISSTAGTTEGSPQRRNDGQLDAAAPPIAQGLMSENTESWVEVASQPSSSSSLSSIGDEIVTTGLRVGSTSYPPRRRRSQVSQQQHPMPASFIVGHPATQGGATSSQEEYDETESEEDRVMTSSTEAIHPSASLLRHQTTVRASAVVDTDSDSDADENATALGRPSNSPVFRPQPNAFSHPPSHLTHRHSTGSAAPYHHHPPSHSRPPMPNRPHARSHRGPPNYMSPSYQADNDAALRASLTTLLSCAAAARGLPKHDERRTVPGAGAGVVPSSQPMELRLVPESELMATDGPPPPPPATPASGGGSKTAAAQARTASNSSAPSAPSSNSGREQQQQRESERSKRAATTQSRPARAAKKKRTSATLLEGEAADADAAPFFSVSPTLLTWVVSAGVVVLVSVVGFGAGYVIGREVGRQEGAATSLGGFGGASSSGVNASSSAAGCGSELVRAGGGSGTLRRIRWGSVGKSVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PR22</accession>
    <name>A0AAN6PR22_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATP synthase regulation protein NCA2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_43707</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854328">
        <property type="protein sequence ID" value="KAK4043396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PR22"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013946">
        <property type="entry name" value="NCA2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28234">
        <property type="entry name" value="NUCLEAR CONTROL OF ATPASE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28234:SF1">
        <property type="entry name" value="NUCLEAR CONTROL OF ATPASE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08637">
        <property type="entry name" value="NCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="557"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4043396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="685" mass="77253" checksum="4E4935F882E726A3" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PS17</accession>
    <name>A0AAN6PS17_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">C8A01DRAFT_43502</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854326">
        <property type="protein sequence ID" value="KAK4043555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PS17"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005366">
        <property type="term" value="F:myo-inositol:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904679">
        <property type="term" value="P:myo-inositol import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000073">
        <property type="entry name" value="MFS myo-inositol transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF12">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
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        </source>
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</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PSA3</accession>
    <name>A0AAN6PSA3_9PEZI</name>
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        <recommendedName>
            <fullName evidence="8">Kelch repeat-containing protein</fullName>
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    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7">CBS 284.82</strain>
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    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
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            <end position="22"/>
        </location>
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        </source>
    </evidence>
    <sequence length="797" mass="84982" checksum="DB9BE73BE607B0C8" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PT81</accession>
    <name>A0AAN6PT81_9PEZI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
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                <person name="Grigoriev I.V."/>
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                <person name="Gladieux P."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854319">
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        <location>
            <position position="1"/>
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    </evidence>
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            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="83" mass="8636" checksum="F27FC314B1AC3367" modified="2024-10-02" version="1" fragment="single">APLESPATLRICTPTKTSRPALKSGTPAIIHRLPPSLVLPAPNPQTARVAPDDERKLKFGSSSLAAFAPEHLSTGATEVVVAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SKZ1</accession>
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        <submittedName>
            <fullName evidence="4">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_20659</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854631">
        <property type="protein sequence ID" value="KAK4032246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SKZ1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11060">
        <property type="entry name" value="CYP57A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF190">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4032246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="474" mass="53238" checksum="ED0C0C3B0D11F4E3" modified="2024-10-02" version="1">MLPLFSAVAALGVLLSVTLLAAIWRAFFPRLASVPGPFAARFTDLWYAYRIYRGGFDKDNRRLHQKYGPVVRYGVNRFSIADPLAANVIYGPGSKFTKSSWYKTWSAPSPHAWSLFSDQDAKRHASNRRQYQNTYSMSALVHYESYVDECADLFCQRLSEMMASDSWSRPVDMGHWLQCYAFDVIGMITYSKRIGFLDFGEDVGDVMRNLGDHLAYASVVGVYPWLHPLLSTVRNWLAGSRGKGRQFIVNFTQECMAAHQAKPKAEISIPEDDAKGEPQRETVDFLSKFVQKHSENPSAFTTYHVLSGCVSNMVAGSDTTSISLSAILYHVLRNPDVLNRLREEVDQHSPQDKASPHITFAKSQSMPYLQAVIKEALRMHPATGLPLERVVPEGGLTISGVFFPEGVIVGINSWVEHANKAIFGDDADTFNPDRWFREDKGRISAMNRHWMPVSVSQYLSSILGVPDYGLAMLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SLC2</accession>
    <name>A0AAN6SLC2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Azaphilone pigments biosynthesis cluster protein L N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_42219</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854881">
        <property type="protein sequence ID" value="KAK4031320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SLC2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031348">
        <property type="entry name" value="PigL_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17111">
        <property type="entry name" value="PigL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Azaphilone pigments biosynthesis cluster protein L N-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4031320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="125" mass="13292" checksum="B159D4D59CA4AB2B" modified="2024-10-02" version="1">MEPLSIAASSFTIVGAIAKASVAIFEFSRQAKDASTDLEGVSSELQALSEILDLLARHISRAPEGTLPASLSQQLGLSLEGCALVVARIDTTIDKYQKDGAWTKTKWAIFGRGDLEKLKGSLEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SLG1</accession>
    <name>A0AAN6SLG1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_41550</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="MU854662">
        <property type="protein sequence ID" value="KAK4032009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SLG1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042668007" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="23"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="5">
        <location>
            <begin position="68"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="540"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="542"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4032009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="630" mass="66561" checksum="E45DA45AE9E446EC" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SMY7</accession>
    <name>A0AAN6SMY7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid permease-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_50277</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854554">
        <property type="protein sequence ID" value="KAK4033060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SMY7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF353">
        <property type="entry name" value="METHIONINE TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="182"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="298"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="351"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="426"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="458"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="510"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="547"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4033060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="671" mass="73969" checksum="F6CDEE95BA006DF0" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SN51</accession>
    <name>A0AAN6SN51_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">transketolase</fullName>
            <ecNumber evidence="4">2.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">C8A01DRAFT_40291</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:10508"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="12">Binds 1 thiamine pyrophosphate per subunit. During the reaction, the substrate forms a covalent intermediate with the cofactor.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transketolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.1" evidence="4"/>
    <dbReference type="EMBL" id="MU854542">
        <property type="protein sequence ID" value="KAK4033255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SN51"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004802">
        <property type="term" value="F:transketolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07033">
        <property type="entry name" value="TPP_PYR_DXS_TK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02012">
        <property type="entry name" value="TPP_TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000003">
        <property type="entry name" value="Transketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000004">
        <property type="entry name" value="Transketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000012">
        <property type="entry name" value="Transketolase, variant 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055152">
        <property type="entry name" value="Transketolase-like_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005478">
        <property type="entry name" value="Transketolase_bac-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020826">
        <property type="entry name" value="Transketolase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049557">
        <property type="entry name" value="Transketolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033247">
        <property type="entry name" value="Transketolase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00232">
        <property type="entry name" value="tktlase_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43522">
        <property type="entry name" value="TRANSKETOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43522:SF6">
        <property type="entry name" value="TRANSKETOLASE-LIKE PYRIMIDINE-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22613">
        <property type="entry name" value="Transketolase_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00801">
        <property type="entry name" value="TRANSKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00802">
        <property type="entry name" value="TRANSKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="15">
        <location>
            <begin position="395"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="462"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="154"/>
            <end position="156"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="398"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="425"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="490"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="514"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="522"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="526"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="573"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="14">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="14">
        <location>
            <position position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK4033255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="739" mass="80539" checksum="9FFA1E76AA424870" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SNQ5</accession>
    <name>A0AAN6SNQ5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_49549</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854501">
        <property type="protein sequence ID" value="KAK4033973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SNQ5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="86"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4033973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="432" mass="45258" checksum="0449BE1C351C7115" modified="2024-10-02" version="1">MGLPPATPAPSRFLISKRTSTQQSQNQTPNQQYAQRSSQFHATPRFAASTPRPSSTQAGGAFTTPALAIKSRVPRNRSTQDIIDDSSPISPEEGSPSASPTTRTTLPEPIEFDSSLVPQSPSPDVNEGRSPKRRRISIASSEPETDPLVNSQPSQQSDLGSLPDAPDDHIVSYHSDVDDDEDDEIDDGNTNISPTHSLPSSPTPHPSPTPEPFESPEPNSSEDDPDPATSKTPNPTTLTLIKKPTFRPGPRFKPAEPPDSTFPSLPDAAYLTADIFSPQRRGGANKYLPGGLAAELRDWLVDVKGGVDGEGGVHSTSAALGFDTTGRGVAGVRVVVDGVERGGVGMTLVCGRAVVAGGTEVVEDGRVRVILAGEGNIEGLGVGRGGGNRELVVPGAVVAVVPPAWDVELDGQWAVAYRWEVVKGGGGQLDGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2025-10-08" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SNT4</accession>
    <name>A0AAN6SNT4_9PEZI</name>
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        <recommendedName>
            <fullName evidence="5">Nucleoporin Nup159/Nup146 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_18986</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854492">
        <property type="protein sequence ID" value="KAK4034152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008139">
        <property type="term" value="F:nuclear localization sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000645">
        <property type="entry name" value="Putative nuclear pore complex subunit Nup159"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026054">
        <property type="entry name" value="Nucleoporin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039462">
        <property type="entry name" value="Nup159/Nup146_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23193">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23193:SF23">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16755">
        <property type="entry name" value="Beta-prop_NUP159_NUP214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117289">
        <property type="entry name" value="Nucleoporin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup159/Nup146 N-terminal" evidence="5">
        <location>
            <begin position="58"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="627"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1343"/>
            <end position="1460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="669"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="686"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="727"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="745"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="788"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="844"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="903"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="1006"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1057"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1362"/>
            <end position="1373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1422"/>
            <end position="1431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4034152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1460" mass="152226" checksum="D263F12B793AC4C5" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SNY7</accession>
    <name>A0AAN6SNY7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Heterokaryon incompatibility protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_48999</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854470">
        <property type="protein sequence ID" value="KAK4034664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SNY7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF1">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="365"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4034664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="991" mass="111276" checksum="40AD5D03ED6D48CD" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SP00</accession>
    <name>A0AAN6SP00_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Endoplasmic reticulum-Golgi intermediate compartment protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_39369</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Plays a role in transport between endoplasmic reticulum and Golgi.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum-Golgi intermediate compartment membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Golgi apparatus membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ERGIC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854492">
        <property type="protein sequence ID" value="KAK4034155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SP00"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033116">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045888">
        <property type="entry name" value="Erv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012936">
        <property type="entry name" value="Erv_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039542">
        <property type="entry name" value="Erv_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984:SF25">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07970">
        <property type="entry name" value="COPIIcoated_ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13850">
        <property type="entry name" value="ERGIC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="398"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter N-terminal" evidence="8">
        <location>
            <begin position="8"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter C-terminal" evidence="7">
        <location>
            <begin position="143"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU369013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4034155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="438" mass="48895" checksum="E35E5718388B4F0D" modified="2024-10-02" version="1">MPPKSRFTRLDAFTKTVEDARIRTTSGGIVTIVSLIVVFFLAWGEWSDYRRIEVHPELIVDKGRSERMEIHLNITFPRIPCELLTLDVMDVSGEQQHGVQHGVTKTRLRPLSEGGGDIDSKAVDLHARDEVATHLDPSYCGPCYGATPPTNAKKPGCCNTCEEVKDAYAQAAWAFGRGEGIEQCEREHYSEKLDEQRNEGCRIEGGLRVNKVVGNFHIAPGRSFSNGNMHVHDLKNYWDTPTKHTFSHTIHHLRFGPQLPDSLHKKLGAKKKSLPWTNHHLNPLDDTHQETDDVNYNYMYFLKIVPTSYLPLGWEKTWAGFREQHHAELGSFGASADGSVETHQYSVTSHKRSLAGGDDAAEGHQERLHARGGIPGVFFSYDISPMKVINREEKAKSFLGFVAGLCAIVGGTLTVAAAIDRALFEGGVRLKKMRSKDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SPA5</accession>
    <name>A0AAN6SPA5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nitrate reductase [NADPH]</fullName>
            <ecNumber evidence="7">1.7.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">C8A01DRAFT_17788</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Nitrate reductase is a key enzyme involved in the first step of nitrate assimilation in plants, fungi and bacteria.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>nitrite + NADP(+) + H2O = nitrate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19061"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16301"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.7.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the nitrate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.7.1.3" evidence="7"/>
    <dbReference type="EMBL" id="MU854440">
        <property type="protein sequence ID" value="KAK4038074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SPA5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050464">
        <property type="term" value="F:nitrate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008482">
        <property type="term" value="F:sulfite oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006790">
        <property type="term" value="P:sulfur compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.420.10">
        <property type="entry name" value="Oxidoreductase, molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005066">
        <property type="entry name" value="MoCF_OxRdtse_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008335">
        <property type="entry name" value="Mopterin_OxRdtase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000572">
        <property type="entry name" value="OxRdtase_Mopterin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036374">
        <property type="entry name" value="OxRdtase_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372:SF7">
        <property type="entry name" value="SULFITE OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372">
        <property type="entry name" value="SULFITE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03404">
        <property type="entry name" value="Mo-co_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00174">
        <property type="entry name" value="Oxidored_molyb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00407">
        <property type="entry name" value="EUMOPTERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56524">
        <property type="entry name" value="Oxidoreductase molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0274">FAD</keyword>
    <keyword evidence="10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="14" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="17">
        <location>
            <begin position="649"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="18">
        <location>
            <begin position="763"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="124"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="190"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="815"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="125"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="819"/>
            <end position="837"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00003838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00015499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAK4038074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1045" mass="118061" checksum="E6029AE92BAF48EF" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SQ25</accession>
    <name>A0AAN6SQ25_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_47572</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854417">
        <property type="protein sequence ID" value="KAK4038854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SQ25"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000149">
        <property type="entry name" value="MFS transporter, SP family, general alpha glucoside:H+ symporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF56">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="390"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="423"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="458"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="491"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="68"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4038854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="570" mass="63849" checksum="F400A7A8006D01BD" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SQL8</accession>
    <name>A0AAN6SQL8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_37042</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854413">
        <property type="protein sequence ID" value="KAK4038992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SQL8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4038992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="434" mass="49498" checksum="F63DF46E171DB14B" modified="2024-10-02" version="1">MTHNTLCHVGALPPELFDKILFELESIRDLANFIATSRFVYRRFEAQRRAVLFRVLQNELGPVLTDARFLFLFPYSDPADEVHYYDWVHTMAAVYCDMLRGDKGYGVRGEAVPSLGELLDLCRTLHKINFLSDAYVAAQLRFFQDAVERTSGPCADLAPPPATAPLSRTERLRVVRAFYRRQIVSNAWASTIRPAHWTSEDTAAISNTSDHGGVRRGLFAAFEPWEMQQIDHAELFITQVCVALLGHAGLHAADHGNTAQPIQKAEFGDLYSHVDRLARYLQTNTSLASTALHGMSSGKSPPGNKDLSREYIYQYQLLPLVYAFQLDRSQTLPDPDRDKRERDEEEIGFVEDHVQLIPFGWVDALNRRYLDRFGDTLDEIPWLRLGSTEKKIARQNTANLWRYTGFALWDRARVEELKNLDRFSGVRTGWVLGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SQU7</accession>
    <name>A0AAN6SQU7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_47729</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854421">
        <property type="protein sequence ID" value="KAK4038708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SQU7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4038708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="246" mass="27316" checksum="C84A51AFA8DEA68A" modified="2024-10-02" version="1">MAPDPVFFELSWSILSTIGAANVFFGLLVISVTNFSPVAAVPLVTSTAGSVANGLCYYAFYSTSPPVANRAVASAFADMLWVVQEAGLSFYSYMILSRILQGKQWYIFASIFWTIILALLAVRILIAVTRVRSIVGSTTGLHLQETVNHLHMAYFPLMAILECVNAYYLLTTFANAKFASFKRARKRDLLQYLMRSTEVRLALLALVGIMRAVTYSFQAQAQMATHIASQVDRFAYTLECLFPIVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SR03</accession>
    <name>A0AAN6SR03_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_47168</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854402">
        <property type="protein sequence ID" value="KAK4039382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SR03"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF42">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="209"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="33"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="319"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="319"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="335"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="346"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4039382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="405" mass="44161" checksum="AC6035A9C4D7FED3" modified="2024-10-02" version="1">MVVYVDLAANPRGVTIIAVLWTMTTLSGLFLGLRLYSKLARTRQLWWDDCVIIVAWILLVVSCSTSTANARLGFGLHTPEVPFENLIPFGLQSNISGFASIIAVACSKTSFGLTLLRLTEGWMKWLIIGLLVLLNATQYLSAIFFWVSCNPPAKTWNPLLPGECWPISVTVNTGLFVGSCSALCDFALALLPWRLLLRFNMYNREKIGVAIAMSMGVFAGISCIVKMTTIPVFYEGDFSYNSLPLVVWGFIEPSLTIMAASIPFMRHLFKSARDLPTITTAATATATTPPNGTATNPTPPRTSVLAAAHANGNNVIINTTTTNNNNQTTSRTHGRSNWGQQQAHQLTERRLPNKARGEDERSDCSMLARPGGAPGNKYDGPSLCCLESDTKHRAVAGVLTCERID</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SRA7</accession>
    <name>A0AAN6SRA7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Crh-like protein</fullName>
            <ecNumber evidence="15">3.2.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">C8A01DRAFT_36605</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Dual chitinase/transglycosylase that plays a role in cell wall architecture. Chitinase and transglycosylase activities are coupled. Required for the polysaccharide cross-linking at the septa and the cell wall. More specifically, transfers chitin to 1,6-beta-glucan in the cell wall.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the glycosyl hydrolase 16 family. CRH1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.-.-" evidence="15"/>
    <dbReference type="EMBL" id="MU854401">
        <property type="protein sequence ID" value="KAK4039395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SRA7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000159">
        <property type="entry name" value="Glycosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017168">
        <property type="entry name" value="CHR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF22">
        <property type="entry name" value="GLYCOSIDASE CRH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037299">
        <property type="entry name" value="Glycosidase_CRH1_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 18" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042959808" description="Crh-like protein" evidence="18">
        <location>
            <begin position="21"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="19">
        <location>
            <begin position="89"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="337"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="17">
        <location>
            <begin position="375"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="393"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="16">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="16">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00093308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR037299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR037299-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAK4039395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="450" mass="47127" checksum="0C68708AC9B49222" modified="2024-10-02" version="1">MVRALLPLGAALLGATAVLAADIPTCSLNKKCPEEAPCCSQYNQCGVGAYCLGGCDPRMSFSLDSCVPAPVCQDKVYKMDSLDRYKDISEYLGDPSKADWVGQGEPLVYDGNVLLTMPAKSVGTVLATTTYMWYGKVKARMKTSRGAGVVTAFILFSDVKDEIDYEFVGVDLQTAQTNYYFQGIPDYVNGGNITIEGANSYDEFHDYEIEWTPDEIKWIVDGKLGRTKKRSETWNATSNQWGFPQTPSRVQISIWPGGADTNAKGTVDWAGGAIDWNSEEIKHFGYYFATFAEVSVECYKTDSAPGTHKGVSYYYNNIAGTNDTVVDSDKPTVLKSFAGTGTDMDKGDGTSGDASQSSSVNTIPGGGSNQVPGGSNPGSGSGSGTGGSGSTGTSGSSACAASGFSQHCDDESSGGGGGGNNSNNGARGVDRTLGASAFAVIVGIAGLLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SRI5</accession>
    <name>A0AAN6SRI5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase C1A papain C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_36524</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854399">
        <property type="protein sequence ID" value="KAK4039486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SRI5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89372">
        <property type="entry name" value="Fucose-specific lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042964109" description="Peptidase C1A papain C-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="3">
        <location>
            <begin position="72"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4039486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="645" mass="70075" checksum="6BE9F57B9998BE2D" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SRK4</accession>
    <name>A0AAN6SRK4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquitin-conjugating enzyme/RWD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_35466</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854375">
        <property type="protein sequence ID" value="KAK4040519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SRK4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23823">
        <property type="entry name" value="RWD_GCN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000075">
        <property type="entry name" value="RWD domain-containing protein (Gir2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040213">
        <property type="entry name" value="GIR2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12292">
        <property type="entry name" value="RWD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00591">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RWD" evidence="2">
        <location>
            <begin position="8"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4040519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="227" mass="25937" checksum="E173FDF0DBEA0321" modified="2024-10-02" version="1">MGREEQIEEREVLDSIFPDEITDISETEYRISITLDIPDDEAEPPIILLTVRYPEDYPDKAPLLELAAPQNSTPHHYLNVAEDKELLLQGLEATVEENLGMAMVFTLVSAVKEAAEQLVEERKEIAAKVQEEAVLAAEREENKKFHGTPVNRETFLKWREGFLKEMEEARIREEEERAAELKKARIKEPTKLTGKQLWERGLATAGQEEVDEDGVPTEEVQKLKVDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SRX0</accession>
    <name>A0AAN6SRX0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_36239</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854392">
        <property type="protein sequence ID" value="KAK4039788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SRX0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14014">
        <property type="entry name" value="STKc_PknB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="46"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="422"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="546"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="588"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="376"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4039788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="737" mass="80855" checksum="272DBEEC514F7638" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SS05</accession>
    <name>A0AAN6SS05_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_16108</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the complex I NDUFA12 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854387">
        <property type="protein sequence ID" value="KAK4039981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SS05"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007763">
        <property type="entry name" value="NDUFA12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12910:SF12">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12910">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE SUBUNIT B17.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05071">
        <property type="entry name" value="NDUFA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0249">Electron transport</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="143"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="180"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4039981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="249" mass="28094" checksum="B70763439682DDBB" modified="2024-10-02" version="1">MSQTPISPMLRAWYKWKTLRLPWRRQFLIGLDLNGNTYWEFLDPGSRLPPSNPSHPLTSPVRWRRIVRYPGNTHPSAVLVPPAWHQWLRHTRADPPSLAEQRAEVARQARIKVLAAEADARWEAKPRVMEDVSPAGGKKKVLGVRQPAFETERHVGPGSKVTAEKRAEAGETSGTGPVTDEVKLGDSEVVNQREETWKQMKKEAEGEGGKEREAGKKTEKGPDPWRQDRGGPSESWQPKAWEPAARGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SS19</accession>
    <name>A0AAN6SS19_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_15208</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854365">
        <property type="protein sequence ID" value="KAK4041014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SS19"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053175">
        <property type="entry name" value="DHMBA_Reg_Transcription_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791:SF13">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="10"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="65"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="83"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="133"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4041014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="595" mass="65177" checksum="3C67CFE1A48B4A30" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SSS4</accession>
    <name>A0AAN6SSS4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitochondrial inner membrane protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_15001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854361">
        <property type="protein sequence ID" value="KAK4041242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SSS4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021836">
        <property type="entry name" value="DUF3429"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15887">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15887:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11911">
        <property type="entry name" value="DUF3429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4041242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="426" mass="47441" checksum="48C523451F0C9E1F" modified="2024-10-02" version="1">MLPATIRARPLRVRPHTCTLAATSRAHPSASFATRTPSSPRVVPRAIAPCGPLQTVFRTQLSTKPPLQPNKIDKEFERQAAEKKLEARPDEVTSSSSVRNVLEASQAPPEDNPDLMVGLKNDLNTVKDTFALKTVPREAFTLGLAGTLPYLATSLSTVVLSWNLNTDWPTQSHFLNAFLLNHESAAHWLHILEPIQVGYGAVIISFLGAIHWGLEFAERQPGGDRTRLRYGIGVLAPAVAWPTIFMPLEWALTTQFAAFASLYYADSRATVKGWAPAWYGSYRFVLTAVVGVAILVSLIGRAKVGKGQNQLTTAALADRIKAKPKYTGKHHNWAKEEEEERERIREEKQQEEKKRKGEEKKAKEEEEKKKKKQAKQEEGAADIESKDEDQKEDQDREEGGASFKSNEGPDANENQTDDAKQKNQQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6ST59</accession>
    <name>A0AAN6ST59_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_45641</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854363">
        <property type="protein sequence ID" value="KAK4041093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6ST59"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF3">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4041093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="284" mass="30854" checksum="41A5D1F8D7882B25" modified="2024-10-02" version="1">MTEDTPAAGTSGAAAAAAPADIEMAEGAAAENPDGSELPFAEGVPEEDPVPKRVSFTQYLSSPIVTLLIGSGDSETILTAHQGLLTQSPYFADACAEFADDGSPRQIELPGEDLDAMGCFLEFLYTGDYFPKKVPGQRTLEKDPSIPDVDMTGDQLLKHAKVYTLAEKFGLTLLKNLASSKIHCVNSTAKGEIAYARYVYQFTAKDDTSIRVPVANFWATRSHTLRAEAEDEFRGLCLEYPQFGYDVLTRVLDEKLKRERNEKMHPGAPGSARKRPRHSSSTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6ST77</accession>
    <name>A0AAN6ST77_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome c oxidase assembly factor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_14092</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854343">
        <property type="protein sequence ID" value="KAK4042274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6ST77"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014807">
        <property type="entry name" value="Coa1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042432">
        <property type="entry name" value="Coa1_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28523">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28523:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08695">
        <property type="entry name" value="Coa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4042274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="224" mass="24808" checksum="BEEA32BBD38D4F0A" modified="2024-10-02" version="1">MLSRLAQQRAGGHAALLRRRIVQAARRIPETPAARPQQKRTLVSAPKPGDGPLMERRPDRELPSLEQTTFRWSRTLPLFAAVIALASVAIFNYQKLSSPVVGATLYALRTSDKARAHLGDEIYFAQQIPWISGEMNQLHGRINITFRVKGTKAGGVMKFASYRPSPRGMFETTEWSLETDAGVVIDLLEDGDPFREMTGAAAADVEEEEESVAAATRGFRKMTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6STG3</accession>
    <name>A0AAN6STG3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_34058</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854349">
        <property type="protein sequence ID" value="KAK4041947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6STG3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4041947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="161" mass="18612" checksum="544D5B24BFF202F1" modified="2024-10-02" version="1">MEILQFSEAFRVVGEKLEFACVKGIVRYNPSVYFGKWQDRRHPPLSLSELYDVKRVETDDKGPETPSLFDYASTPDLERQVHNDITPANIMRDEEDGAWVIIDFDSCRHVGEVLRDNTWAKRTHGWHDPGVAVSSEKNDLDAFSELRAWLFGSSADEFLFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6STW9</accession>
    <name>A0AAN6STW9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Myosin II heavy chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">C8A01DRAFT_44969</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Binds to cdc4 and rlc1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854348">
        <property type="protein sequence ID" value="KAK4041991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120104">
        <property type="term" value="C:mitotic actomyosin contractile ring, proximal layer"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Slow myosin heavy chain 2"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SH3_Myosin"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF857">
        <property type="entry name" value="MYOSIN-11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24319">
        <property type="entry name" value="DUF7491"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02736">
        <property type="entry name" value="Myosin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90257">
        <property type="entry name" value="Myosin rod fragments"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51844">
        <property type="entry name" value="SH3_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 9" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 9" id="KW-0518">Myosin</keyword>
    <keyword evidence="2 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin N-terminal SH3-like" evidence="13">
        <location>
            <begin position="68"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="12">
        <location>
            <begin position="122"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="9">
        <location>
            <begin position="694"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1606"/>
            <end position="1643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="2331"/>
            <end position="2353"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="893"/>
            <end position="1508"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="1664"/>
            <end position="1691"/>
        </location>
    </feature>
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        <location>
            <begin position="1878"/>
            <end position="2004"/>
        </location>
    </feature>
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        <location>
            <begin position="2054"/>
            <end position="2299"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="215"/>
            <end position="222"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023123"/>
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        </source>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00064372"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51844"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK4041991.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2353" mass="269385" checksum="E0E39E793EA4E161" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SU14</accession>
    <name>A0AAN6SU14_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_44923</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854347">
        <property type="protein sequence ID" value="KAK4042038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050602">
        <property type="entry name" value="Malonyl-ACP_OMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13090">
        <property type="entry name" value="ARGININE-HYDROXYLASE NDUFAF5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13090:SF1">
        <property type="entry name" value="ARGININE-HYDROXYLASE NDUFAF5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="3">
        <location>
            <begin position="119"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4042038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="351" mass="38137" checksum="FD73673ACC91E0EC" modified="2024-10-02" version="1">MRLNLPRACRPQSLRSLASPASARRTYAFQAPGGAVFKVFNSRAKWHQKERAAANPELSRQADYLKEEVAMRVCERLLDIKRHFPRVLDLGANSCNIARALTRENPDPDPATPTSPPLASKITSLIAADSSAALLHRDAALPLTSPLNLTRQVLPDDESLPFAPSSFDMVLSSMSLHWINDLPGVLAQINSVLKPDSPFIGAMLGGDTLFELRTSLQLAEQERRGGISPHVSPLADVRDVGGLLGKAGFQMLTVDVEDIVVDYPDTFALMQDLQAMGEGNAVLGREMGAIGRDVLLANEGIYRALHGNEDGTLPATFRIIHMIGWKEGGNQPKPLKRGSGEVNLKDILEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SUH1</accession>
    <name>A0AAN6SUH1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_13686</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854337">
        <property type="protein sequence ID" value="KAK4042725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SUH1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="91"/>
            <end position="176"/>
        </location>
    </feature>
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        <location>
            <begin position="319"/>
            <end position="481"/>
        </location>
    </feature>
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            <begin position="106"/>
            <end position="123"/>
        </location>
    </feature>
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            <begin position="164"/>
            <end position="176"/>
        </location>
    </feature>
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            <begin position="384"/>
            <end position="398"/>
        </location>
    </feature>
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            <begin position="427"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4042725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="481" mass="51705" checksum="18609E98550449D2" modified="2024-10-02" version="1">MREPSSDQGERGEQRCCISSDAEGRILTTSFPPFSHPLSVRPIPEAFYHLERFDSENTGTAIAQIGRAISPVPSSQKVDNIRWHKWLGQPSSPLSSRAAVEGSRASLEHRLSPGISEVRRPKQEPPPSSPPSSGFTTENLVDSVKSREEEMVPLSSPHDHEESSVSARVGSQEQGSAATNIAEVLDLKHIPGDFSSSQPPLAEQVCAESDGTDPDEAWKTFVFGYEKSDEVSKAAFEEAKHDAIRSLQPSEFLVPSDEGSGSDGHSHIATVGTIYTKHDDETFEYAEPCFHAEVSGSLEATCGPSSTRVESGVAMDLSDEFAQDPSLRVNAGTSSISDLERAPDSPDNSGFVSAEEADSSTSALHAGAPSMTTSMAVAPARSDAVSSETGTTAEQFRFSQPKLFVGSRSNPSQPVRPAGPGVGISLTKRRRGRSKKRTNDGRADIRALPNYSGDPIEEFEEERVPKEGRLPKSLFPALELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SUL0</accession>
    <name>A0AAN6SUL0_9PEZI</name>
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        <recommendedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">C8A01DRAFT_13606</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854335">
        <property type="protein sequence ID" value="KAK4042830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SUL0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="232"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="527"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="356"/>
        </location>
    </feature>
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        <location>
            <begin position="382"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="588"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="643"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="672"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="782"/>
            <end position="810"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4042830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="810" mass="88083" checksum="B6B8C29D7B1F2419" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SUP4</accession>
    <name>A0AAN6SUP4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ams2/SPT21 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_33024</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854334">
        <property type="protein sequence ID" value="KAK4042920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000183">
        <property type="term" value="P:rDNA heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030466">
        <property type="term" value="P:silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057725">
        <property type="entry name" value="Ams2-SPT21_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042403">
        <property type="entry name" value="Spt21/Ams2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39147">
        <property type="entry name" value="PROTEIN SPT21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39147:SF1">
        <property type="entry name" value="PROTEIN SPT21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25823">
        <property type="entry name" value="Ams2-SPT21_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ams2/SPT21 N-terminal" evidence="2">
        <location>
            <begin position="28"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="513"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="881"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1016"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1119"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1295"/>
            <end position="1320"/>
        </location>
    </feature>
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        <location>
            <begin position="247"/>
            <end position="259"/>
        </location>
    </feature>
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        <location>
            <begin position="288"/>
            <end position="299"/>
        </location>
    </feature>
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        <location>
            <begin position="416"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="631"/>
            <end position="669"/>
        </location>
    </feature>
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        <location>
            <begin position="892"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="911"/>
            <end position="921"/>
        </location>
    </feature>
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        <location>
            <begin position="938"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="959"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1086"/>
            <end position="1097"/>
        </location>
    </feature>
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        <location>
            <begin position="1119"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1151"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1295"/>
            <end position="1309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1310"/>
            <end position="1320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4042920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1320" mass="141471" checksum="32006F12476A7A69" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SUV3</accession>
    <name>A0AAN6SUV3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Splicing factor YJU2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_13021</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Part of the spliceosome which catalyzes two sequential transesterification reactions, first the excision of the non-coding intron from pre-mRNA and then the ligation of the coding exons to form the mature mRNA. Plays a role in stabilizing the structure of the spliceosome catalytic core and docking of the branch helix into the active site, producing 5'-exon and lariat intron-3'-intermediates.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the spliceosome. Present in the activated B complex, the catalytically activated B* complex which catalyzes the branching, the catalytic step 1 C complex catalyzing the exon ligation, and the postcatalytic P complex containing the ligated exons (mRNA) and the excised lariat intron.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CWC16 family. YJU2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854327">
        <property type="protein sequence ID" value="KAK4043462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SUV3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000349">
        <property type="term" value="P:generation of catalytic spliceosome for first transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03226">
        <property type="entry name" value="YJU2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Saf4/Yju2"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
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        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
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            <end position="136"/>
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    </feature>
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            <end position="317"/>
        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
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            <begin position="116"/>
            <end position="125"/>
        </location>
    </feature>
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        </location>
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            <end position="293"/>
        </location>
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        <location>
            <position position="52"/>
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        </ligand>
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    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="317" mass="35384" checksum="500808D6CE274D5C" modified="2024-10-02" version="1">MSERKVLTKYYPPDFDPSQIGRARKPKGGLSAAQQGPKVQTVRLMAPFSLRCVACGEYMYRGRKFNARKETPQGEKYLGIQLYRFYIRCTRCSAEIVFRTDPKNQDYVMERGAKRNTDPWKRGLDDTTGDETDEQRLDRLEREMAEAEGEEERNAMAELEAKTEDAKREMAVADALDEIRGRNARLERANRESGGDVLEAVVAGVVRPEEEERRRQEEEDAEAARRAFAFVRRQDMLEEVVEEEGEDGVVDGNGNGAGSGSASSSAAASTSDSKPPSAAATPDMMPPPPPPPSFKRQVKKKKDHAALLGIKKKQPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SVJ0</accession>
    <name>A0AAN6SVJ0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_12750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854324">
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    </dbReference>
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            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK4043820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="315" mass="35561" checksum="06D1C86E2F79B72E" modified="2024-10-02" version="1">MEQIRRKELERTQLRMLSTLYEYLDSNCRSMTSVDAAELEALGIARWTDLDVDGQLPCDFEPLFFSPCHEECPGLEEETEYWRPVWRATLDTPQNLLDPEWVPSAGYVYASVKARWFQAIPAHLTDQYDAELHPANVYKGHSDPHYASPRGYCGRDWYESEPCVVPVAADKPHMMITVLEPAVATEGNLLWSEFNAIIALLESRIRMAQFTDHHTKPVLIFAFQRDTHARITQAHIDAKTNKIVIRQSRQLDLVGAPGEPPADAYLLLRWLLNSPVGATKYEDEELPGQGARKKGAETGGAEMPTVPKIVDVKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="3">Exocyst complex component Sec10-like protein</fullName>
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        <name evidence="3" type="ORF">C8A01DRAFT_42372</name>
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    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
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        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854316">
        <property type="protein sequence ID" value="KAK4044750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SWE7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0006887">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009976">
        <property type="entry name" value="Sec10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048627">
        <property type="entry name" value="Sec10_HB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12100:SF1">
        <property type="entry name" value="RECYCLIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Sec10_HB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="33"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="543"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="153"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="548"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="558"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4044750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="963" mass="106496" checksum="85AFB158D7D25F13" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P3V2</accession>
    <name>A0AAN6P3V2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_21540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
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            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854985">
        <property type="protein sequence ID" value="KAK4031209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P3V2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4031209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="281" mass="30064" checksum="2B48EE7F9D167D7D" modified="2024-10-02" version="1">MDVRGSDTQEATGWGATPIILASVLAAVLFASIVGSLSMRKRAKVMAADLETAMAELGVQQGRAVSLQQELNRRDAFIDRNVIQGPDVYSAAPPIRSRDPVPEEVHSDPFAVGSDEESSDEESSDEESSDEESSEDESDDSDRSDDDESAESRTTVTPDCQLPKDDLWHEVKMEESPEDQSSWSLPQRDDSQAQVGSYWGEDTAELLPQGVAPSLVAGEGPAEVETTTTEVDRAKVCDKDVGAVPAPIVSSGSGSPPGGPDTPESFMSPPVIEACHYPLPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P545</accession>
    <name>A0AAN6P545_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">C8A01DRAFT_51204</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="2"/>
    <dbReference type="EMBL" id="MU854690">
        <property type="protein sequence ID" value="KAK4031854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P545"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20335">
        <property type="entry name" value="BRcat_RBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="1"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="5"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK4031854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="196" mass="21292" checksum="31B06B157D51EB85" modified="2024-10-02" version="1">MAIGCVVCMESKAAAAFPGSPLTDRCNHAPRTCLECVSGSIRTHIESGLSTDVPCPECTGIMSSADIQRYADSKTRQRYDELRLYRVVEEDEDFIWCSAGCGSGQIHEDGLAQPIVKCASCGCKTCFLCKVPWHVGLTCDEWSSLVAASAADDTSAQTLLQRAEELRASKDTIDQTTKPCPRCSWNIEKNGGWCVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P5B5</accession>
    <name>A0AAN6P5B5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_41523</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854658">
        <property type="protein sequence ID" value="KAK4032044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P5B5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="462"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4032044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="671" mass="74085" checksum="0D77805C984C322B" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P5L4</accession>
    <name>A0AAN6P5L4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_41360</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854636">
        <property type="protein sequence ID" value="KAK4032193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P5L4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="2-AMINO-3-CARBOXYLMUCONATE-6-SEMIALDEHYDE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240:SF31">
        <property type="entry name" value="AMIDOHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_7G05840)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="4">
        <location>
            <begin position="60"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4032193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="353" mass="39039" checksum="F5F47F709DEE10F9" modified="2024-10-02" version="1">MAQKTPKGTIAIEEAVLNPAGLSWIAESAPLFNPGQGSSSSSSADAPKHGLNQLLLDIHHERLAQMDAHGIEYMLLSLTSPGAQGEPDPAKARTLAAEANDWLAAQVEQNPARFGAFAAVSMHNAADAVAEATRAVKELGMFGVMVNDYQIAGEGGNAEGKKYYDEAEFRSFWKAIEELGVPVYFHPRYPPAKDLEPGTRFGDRKHILGAAVQFHLDLSMHLYAICSSGVFDEFPKVQVVVGHLGEGIPFNLWRADHWYNKPVKKATRPSKQDYSYYFTHNISITTSGNFNTAALKFCVDQIGPERCLYSIDYPYDTIAEAQQWWLTADLPEEQKKLVARENAIRLFKLPLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P6B3</accession>
    <name>A0AAN6P6B3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_40988</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854595">
        <property type="protein sequence ID" value="KAK4032568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P6B3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="10"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="52"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4032568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="100" mass="11065" checksum="AF3E2D5DAEE5C27C" modified="2024-10-02" version="1" fragment="single">MATGTCRATLEGYSNVVLSVVFSHDSKTLVSRSYDETIKLWDTAMYACRATLKGYSRPVNSVVFSYNSKTLASGLFDGLFKLWDAVTGAYRVTLEGYSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P6F5</accession>
    <name>A0AAN6P6F5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_42234</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854891">
        <property type="protein sequence ID" value="KAK4031298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P6F5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF105">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4031298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="285" mass="30802" checksum="6C179357EDDD330A" modified="2024-10-02" version="1">MAGKQESKYWMESEGERKRLASNHYIAKDAMGSELVRAPVDFSRPVKVLDSGTADGTWLLDLASSLPPPASGSHEFVGTDLNPAPFPSSTPPNVTFAVQDIKKPWAESQHGQFDLVHQRLTLLGAGSNPSASIAHLGALVKPGGWIQISEGTMDFPPDVVSDERTPAYCDMLRLMRAVAGAVGAEWHLGRTLRGLLEAAGFTDIGEEDVVLNIGRTNKDEGLAREGAETCSIAVQGLSRFAQNFAPEKQPLPAERYKTLAADLEKELAEKGAVYPLKVVWGRKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P6R2</accession>
    <name>A0AAN6P6R2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_40779</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854576">
        <property type="protein sequence ID" value="KAK4032778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P6R2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007632">
        <property type="entry name" value="Anoctamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049456">
        <property type="entry name" value="Anoctamin_N_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049452">
        <property type="entry name" value="Anoctamin_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308:SF77">
        <property type="entry name" value="MEMBRANE STRESS RESPONSE PROTEIN (IST2), PUTATIVE (AFU_ORTHOLOGUE AFUA_4G03330)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04547">
        <property type="entry name" value="Anoctamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20877">
        <property type="entry name" value="Anoctamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="183"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin alpha-beta plait" evidence="7">
        <location>
            <begin position="20"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin transmembrane" evidence="6">
        <location>
            <begin position="174"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4032778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="252" mass="28314" checksum="EA6A31FA423233D2" modified="2024-10-02" version="1">MEPPATLKPSVSHQTQAYNDQYVIVYRFKDVDPDVASKEIALMCQDLASASLQTEIRAGCDRTLLVFVKAPREILGSFVYNSRVKDWLYGIVQSHPGGVKNAVVDGAFEAEDILSIYHLVNWPKTNGGAGITPGWGQWENVESIFPLHNEAANMALLKQLSSRLFLANNDLDQIRNLSGTKAAFYFAFIQTYAVFLAFPAITGLLAWRFLPSYSLVYAIITTVWCTVFLEHWKIRQTDLSIIHLLTITHARM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P7L5</accession>
    <name>A0AAN6P7L5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Iron-sulfur assembly protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">C8A01DRAFT_50219</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in the assembly of mitochondrial and cytoplasmic iron-sulfur proteins. Probably involved in the binding of an intermediate of Fe/S cluster assembly.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the HesB/IscA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854549">
        <property type="protein sequence ID" value="KAK4033145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P7L5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000731">
        <property type="term" value="P:DNA synthesis involved in DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18139">
        <property type="entry name" value="HLD_clamp_RarA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3710.10:FF:000005">
        <property type="entry name" value="AAA family ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.300.12:FF:000001">
        <property type="entry name" value="Iron-binding protein IscA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000001">
        <property type="entry name" value="Putative AAA family ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000137">
        <property type="entry name" value="Replication-associated recombination protein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3710.10">
        <property type="entry name" value="DNA polymerase III clamp loader subunits, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.300.12">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032423">
        <property type="entry name" value="AAA_assoc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051314">
        <property type="entry name" value="AAA_ATPase_RarA/MGS1/WRNIP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016092">
        <property type="entry name" value="ATAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000361">
        <property type="entry name" value="ATAP_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017870">
        <property type="entry name" value="FeS_cluster_insertion_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035903">
        <property type="entry name" value="HesB-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021886">
        <property type="entry name" value="MgsA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006642">
        <property type="entry name" value="Rad18_UBZ4"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00049">
        <property type="entry name" value="iron-sulfur cluster assembly accessory protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13779:SF7">
        <property type="entry name" value="ATPASE WRNIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13779">
        <property type="entry name" value="WERNER HELICASE-INTERACTING PROTEIN 1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16193">
        <property type="entry name" value="AAA_assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01521">
        <property type="entry name" value="Fe-S_biosyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12002">
        <property type="entry name" value="MgsA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00734">
        <property type="entry name" value="ZnF_Rad18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89360">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01152">
        <property type="entry name" value="HESB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBZ4-type" evidence="15">
        <location>
            <begin position="288"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="474"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="63"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="317"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="322"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="361"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00054873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00071673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK4033145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="867" mass="93395" checksum="B323A268CD33F049" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P7N2</accession>
    <name>A0AAN6P7N2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_19776</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854542">
        <property type="protein sequence ID" value="KAK4033258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P7N2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043484">
        <property type="term" value="P:regulation of RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051175">
        <property type="entry name" value="CLK_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE DOA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646:SF11">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE DOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="26"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4033258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="168" mass="19012" checksum="ADA3905DAE60ED3B" modified="2024-10-02" version="1" fragment="single">DQVKWIKYGKNHFCPIILGQVVNDRYRIISLLGFGGAGMVWLAIDEPHPRYYVALKITRGCDRTGNEELTLRLLMQSRDHDSRGGHKIIELFDAFDIESANGIHRCLVLELAAGSLVDIKHHEEFTFDQHLVMFKQCVQAVAHLHSQGLVHGGNHRLPPTLSPVDTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P7R7</accession>
    <name>A0AAN6P7R7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ubiquitin thioesterase OTU</fullName>
            <ecNumber evidence="9">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">C8A01DRAFT_19747</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Hydrolase that can remove conjugated ubiquitin from proteins and may therefore play an important regulatory role at the level of protein turnover by preventing degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="9"/>
    <dbReference type="EMBL" id="MU854540">
        <property type="protein sequence ID" value="KAK4033279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P7R7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22745">
        <property type="entry name" value="OTU_OTU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048857">
        <property type="entry name" value="OTU1_Ubl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057766">
        <property type="entry name" value="Znf-C2H2_OTU1-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13312">
        <property type="entry name" value="HIV-INDUCED PROTEIN-7-LIKE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13312:SF0">
        <property type="entry name" value="UBIQUITIN THIOESTERASE OTU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21403">
        <property type="entry name" value="OTU1_UBXL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24560">
        <property type="entry name" value="zf-C2H2_OTU1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5 9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="OTU1 Ubl" evidence="12">
        <location>
            <begin position="7"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="OTU" evidence="11">
        <location>
            <begin position="133"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="OTU1-like C-terminal C2H2-type zinc finger" evidence="13">
        <location>
            <begin position="269"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="93"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF21403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF24560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK4033279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="306" mass="34436" checksum="0810002C491FB628" modified="2024-10-02" version="1">MLIQISLRSPNGQSRVQIEDDATLKELVELIKAKTELSNFSLKYGYPLKSLDISPSLQDASIKDLKLRGETIVVAPVDTAPPVPALQPASAEPEPKPFKPKGIEPDETSLEWPERGGHIVTAFGGAIGLENPSKTLRNQVADYILNHPNEYNKAILGEEPQRYTTRMRQMDTWGGAIELSILSDIYNLEISSLDVKSLRVDRFGEGKSNRVIILYSGIHYDRIAFCMDLSYPVEVDVTRWATDDDEVLDKARQLAQRLQNMHYYTDTTDFVIKCEVCNWIGQGTREAARHERETGHGQFGEMQITD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P842</accession>
    <name>A0AAN6P842_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Galactose mutarotase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_19584</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldose epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854528">
        <property type="protein sequence ID" value="KAK4033474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P842"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004034">
        <property type="term" value="F:aldose 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose, Leloir pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09019">
        <property type="entry name" value="galactose_mutarotase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.10:FF:000014">
        <property type="entry name" value="Aldose 1-epimerase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047215">
        <property type="entry name" value="Galactose_mutarotase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10091:SF2">
        <property type="entry name" value="ALDOSE 1-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10091">
        <property type="entry name" value="ALDOSE-1-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043037819" evidence="4">
        <location>
            <begin position="19"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4033474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="386" mass="42192" checksum="46AC1B8CDB53828B" modified="2024-10-02" version="1">MKFSLPLLVAVAEAAVMGRGPGCDVPPPDKDGRYTISAPGIKAQFIPYGATLTNLFVKDKNGKDVDVVLGYDDVEYYPKDPGHPVYNAIPGRYANRIGNGHYTIDGVTYETEQNDGNNTLHSGTNNWSYRFWNVTAFSPDSITFSILDASNSSKGMPGRVESSVTYSVKGSTWKIQMTAKSLDQKTPLLLTQHTYFNLDAYRNPSTSKIWDHTLHLPYSKRYLEADQGALPTGKILTAAPNSINDFASASDLTVGHARDQPGFEGNCGADGACEGYNGYWLIEGAPKDAVVVTLASKFSGVKAELRTDQPGVVLYSCNWMDGSADLKSTQGIEGVNDKVIRSSCIAIEAQDYPDGINHPEWKRTEAQIWGPGQTYKWESSWTFGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P8J9</accession>
    <name>A0AAN6P8J9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cell pattern formation-associated protein stuA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">C8A01DRAFT_49730</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EFG1/PHD1/stuA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854512">
        <property type="protein sequence ID" value="KAK4033751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P8J9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048315">
        <property type="term" value="P:conidium formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.260.10:FF:000003">
        <property type="entry name" value="Ascospore maturation 1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.260.10">
        <property type="entry name" value="Transcription regulator HTH, APSES-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029790">
        <property type="entry name" value="EFG1/Phd1/StuA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036887">
        <property type="entry name" value="HTH_APSES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018004">
        <property type="entry name" value="KilA/APSES_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003163">
        <property type="entry name" value="Tscrpt_reg_HTH_APSES-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47792">
        <property type="entry name" value="PROTEIN SOK2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47792:SF1">
        <property type="entry name" value="PROTEIN SOK2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04383">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01252">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54616">
        <property type="entry name" value="DNA-binding domain of Mlu1-box binding protein MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51299">
        <property type="entry name" value="HTH_APSES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0183">Conidiation</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0749">Sporulation</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH APSES-type" evidence="10">
        <location>
            <begin position="137"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="244"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="501"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="577"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="244"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="285"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="329"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="382"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="397"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="451"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="466"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="577"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="621"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK4033751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="642" mass="68420" checksum="42C372CB6C005559" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P8N9</accession>
    <name>A0AAN6P8N9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">C8A01DRAFT_19301</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854509">
        <property type="protein sequence ID" value="KAK4033811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P8N9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11058">
        <property type="entry name" value="CYP60B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF230">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="456"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK4033811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="512" mass="57746" checksum="39E31B8C0DC6EC8B" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P8U3</accession>
    <name>A0AAN6P8U3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_39658</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854505">
        <property type="protein sequence ID" value="KAK4033888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P8U3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4033888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="250" mass="28963" checksum="AB5E58EF45F6EF4F" modified="2024-10-02" version="1">MDLGARIAAEKFYRDLREVFPDYAADFEQKFTEWQGKWFDPESPGSSSALERCELPEYDPLLFLGPKTIPLLVFELTKPGNFIATTLYNHLETDPQAKVDPEDIINYLTLNRHANLIVELNHERAQRVRRRLEAWKTRCRQLQQQQQPGQLQKQQSAELDTTACEEYDALVAMGSGIIAHVMLEYSKDRAGPWCQLMHQLVCEKPMGVMAHPGGLKQYEAWRDWFENREHHEAAEEGLMPAYLNNVGRWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P8V3</accession>
    <name>A0AAN6P8V3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AN1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_40666</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854567">
        <property type="protein sequence ID" value="KAK4032885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P8V3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1110.10">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035896">
        <property type="entry name" value="AN1-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057358">
        <property type="entry name" value="UBL_ZFAND1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000058">
        <property type="entry name" value="Znf_AN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14677">
        <property type="entry name" value="ARSENITE INDUCUBLE RNA ASSOCIATED PROTEIN AIP-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14677:SF40">
        <property type="entry name" value="CDC48-ASSOCIATED UBIQUITIN-LIKE_ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25327">
        <property type="entry name" value="UBL_ZFAND1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01428">
        <property type="entry name" value="zf-AN1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00154">
        <property type="entry name" value="ZnF_AN1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118310">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51039">
        <property type="entry name" value="ZF_AN1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="AN1-type" evidence="5">
        <location>
            <begin position="29"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="AN1-type" evidence="5">
        <location>
            <begin position="98"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4032885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="318" mass="34457" checksum="52813BFE4ECB2B2D" modified="2024-10-02" version="1">MASPDPNSDETSYIKMSTAAVESRGTDASLIGSHCQYSYCNQLDFLPFQCQSCDKTFCLDHRTEDSHACANPGAWAARKRAADLARHSAGEGRRMRDLVAQKPCADDGCKTTIGTTLVPGVHCANCNRDYCLKHRLREDHACSSKVPIGARAASAAQAAAVAEGAKSALERFRLWGQAKKQQAKVSFASPSAKPKVAQMLAVNNLKKTAKGDAKIAPEKRVYLYVEAEAATAKAKIHKGEFFYSQDWVVGKMLDAAARSLQVQNINNQSSSEEDMLRVFHVEGGRLLEFSEKLGKVLQSGNTVVLLRGVGPPPDLIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P979</accession>
    <name>A0AAN6P979_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zeaxanthin epoxidase, chloroplastic</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_41773</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854702">
        <property type="protein sequence ID" value="KAK4031787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P979"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053212">
        <property type="entry name" value="DHP_3-monooxygenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054707">
        <property type="entry name" value="DhpH_subs-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47469">
        <property type="entry name" value="MONOOXYGENASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47469:SF2">
        <property type="entry name" value="OS06G0597600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22607">
        <property type="entry name" value="FAD_binding-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="405"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="2,6-dihydroxypyridine 3-monooxygenase substrate binding" evidence="3">
        <location>
            <begin position="188"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4031787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="429" mass="46810" checksum="E5AC1B2721798444" modified="2024-10-02" version="1">MSNLPKSVVIVGGSLAGLLHGLYLKRHGSNVVILEQDPNSIRSSHQAGIAFGPAVQEILAKYDDTGMQSCIPATSTRIAYRRSWELSLNIARRLTSWGLLYRTLRANFDGLASEAVPNPPPPRAGDGKAEYRSGKKVTDLRYDNGVITISFVSQDGTEDSLTADLVIGADGLHSTVRTLLQAPTVKEYSGYVSWRGTVPEKDLPPATVQYFSNRPTLSFLKGTYLVCYPIPPDTGTFTPGTLLLNWVWYCPPSKGDLPTLLTDRTGHTHSNTVPAGLINPAIWASQLASTLESMPPPVATLLSSTKPSAVFVTKVNDALCERAVFCDGKVVLVGDALVTFRPHVAVATEHAARHCLGLGRVWGQEHEEGKGVVMMTMGEWEREVRGYGERVWMASRVLGVWGVGGWWEFWGVVWGFVRILVGGLLRGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P9C2</accession>
    <name>A0AAN6P9C2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytochrome c oxidase-assembly factor COX23, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_18998</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the assembly of cytochrome c oxidase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the COX23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854493">
        <property type="protein sequence ID" value="KAK4034134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P9C2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033108">
        <property type="term" value="P:mitochondrial respiratory chain complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010625">
        <property type="entry name" value="CHCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051040">
        <property type="entry name" value="COX23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009069">
        <property type="entry name" value="Cys_alpha_HP_mot_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46811">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46811:SF1">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06747">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47072">
        <property type="entry name" value="Cysteine alpha-hairpin motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHCH" evidence="8">
        <location>
            <begin position="34"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF06747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4034134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="82" mass="9461" checksum="1794E1DA64DAD1F5" modified="2024-10-02" version="1">MAPRTNSDGNPWNRETKDKFEGKDRSEFLDPCQEAAARSIRCLHRNGGDRTLCSDYFQAYRDCKKAWIEKRKTDKKGGGLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P9C3</accession>
    <name>A0AAN6P9C3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_40314</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854544">
        <property type="protein sequence ID" value="KAK4033217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P9C3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4033217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="115" mass="12655" checksum="9062B790CC266268" modified="2024-10-02" version="1" fragment="single">MNSHTVSIHGLTYDEKATLLDEKSASDIERDARRADLTSRFSATNQWTTITITTHAAHRALNNLPSLLRRIAIFLLPSFIQPLLTNSPPSQPPRPGPTAYLDGLRGLAALAVFFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PAE1</accession>
    <name>A0AAN6PAE1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="20 21">Cytochrome b-c1 complex subunit Rieske, mitochondrial</fullName>
            <ecNumber evidence="3 21">7.1.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">C8A01DRAFT_48931</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>a quinol + 2 Fe(III)-[cytochrome c](out) = a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:11484"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="7.1.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="21">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
        <text evidence="21">Binds 1 [2Fe-2S] cluster per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="21">The Rieske protein is a high potential 2Fe-2S protein.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Rieske iron-sulfur protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.8" evidence="3 21"/>
    <dbReference type="EMBL" id="MU854467">
        <property type="protein sequence ID" value="KAK4034734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PAE1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008121">
        <property type="term" value="F:quinol-cytochrome-c reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03470">
        <property type="entry name" value="Rieske_cytochrome_bc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.270:FF:000002">
        <property type="entry name" value="Cytochrome b-c1 complex subunit Rieske, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.102.10.10:FF:000001">
        <property type="entry name" value="Cytochrome b-c1 complex subunit Rieske, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.270">
        <property type="entry name" value="Ubiquinol cytochrome reductase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037008">
        <property type="entry name" value="bc1_Rieske_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014349">
        <property type="entry name" value="Rieske_Fe-S_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005805">
        <property type="entry name" value="Rieske_Fe-S_prot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004192">
        <property type="entry name" value="Rieske_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006317">
        <property type="entry name" value="Ubiquinol_cyt_c_Rdtase_Fe-S-su"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01416">
        <property type="entry name" value="Rieske_proteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10134">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02921">
        <property type="entry name" value="UCR_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00162">
        <property type="entry name" value="RIESKE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81502">
        <property type="entry name" value="ISP transmembrane anchor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12 21" id="KW-0249">Electron transport</keyword>
    <keyword evidence="14" id="KW-0408">Iron</keyword>
    <keyword evidence="15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16 22" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 22" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="11" id="KW-1278">Translocase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 21" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Rieske" evidence="23">
        <location>
            <begin position="132"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00029351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00072517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU004494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU004495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KAK4034734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="228" mass="24213" checksum="427DA9E136548DE5" modified="2024-10-02" version="1">MAPLQTMSRALARSASARLPTATAAAAVRAASSSSFESPFKGESKSSKVPDFSKYMSKGSGGTNALFSYFMVGTLGAISAAGAKSTIQEFLVNMSASADVLAMAKVEVDLAAIPEGKNVIIKWRGKPVFIRHRTAAEIDEANSINVASLRDPETDDQRVKKPEWLVMLGVCTHLGCVPIGEAGDFGGWFCPCHGSHYDISGRIRKGPAPLNLEIPEYDFSEDGKLVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PAM7</accession>
    <name>A0AAN6PAM7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_39660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854505">
        <property type="protein sequence ID" value="KAK4033890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PAM7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="398"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="474"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="535"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="484"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="501"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="551"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4033890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="602" mass="67087" checksum="18F2375D8FA1773A" modified="2024-10-02" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PB16</accession>
    <name>A0AAN6PB16_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">1,3-beta-glucanosyltransferase</fullName>
            <ecNumber evidence="9">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">C8A01DRAFT_19967</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cell membrane</location>
            <topology evidence="1 9">Lipid-anchor</topology>
            <topology evidence="1 9">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 72 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="9"/>
    <dbReference type="EMBL" id="MU854556">
        <property type="protein sequence ID" value="KAK4033036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PB16"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042124">
        <property type="term" value="F:1,3-beta-glucanosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071970">
        <property type="term" value="P:fungal-type cell wall (1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004886">
        <property type="entry name" value="Glucanosyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468:SF5">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03198">
        <property type="entry name" value="Glyco_hydro_72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 9" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8 9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042662944" description="1,3-beta-glucanosyltransferase" evidence="9">
        <location>
            <begin position="17"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="404"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="405"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="416"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK4033036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="466" mass="49984" checksum="F769C2B0F25FA9DA" modified="2024-10-02" version="1">MKSAALVSALAAAVHAGPTTTLKSKPRATELEPITVTGNAFFKGTERFYVRGIDYQPGGASANIDPLADTKVCLQDIEKFKTLGVNTIRVYSTDNSKNHDECMNALADAGIYVVLDANNPLYSINREDPHGSYNTPYLQSVFATIDAFAKYSNTMAFFSGNEVIHDFKNTTLTAKYVKATDRDMRRYIKARNYRKILVGYSAADVTTNVMQTAAYFNCGEEHERSDFFAFNDYSWCTSDFITSGWNKKVEAFSDYGLPLFLSEYGCHQNPRNFGELESLMHSNMTSVYSGGLMYEYSYEPNKFGIVEIEGGQANGGADQTGKRKELDEFEAFANALKKWPAPTGDGGYTKTTKVSACPTEDSHWAIGSATLPDIPEGALKFFDEGAGKGPGLKGDGSQWAIDQASTSEGGQSSDGSGSGGSGTSGGSGASTSSSAAMRGTVPAMEKAPFVVSGIVLLCTLVGAVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2025-10-08" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PB98</accession>
    <name>A0AAN6PB98_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">C8A01DRAFT_39321</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854490">
        <property type="protein sequence ID" value="KAK4034192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
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        <property type="match status" value="2"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="478"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="517"/>
            <end position="538"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="577"/>
            <end position="606"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="697"/>
            <end position="718"/>
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    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1127"/>
            <end position="1144"/>
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    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
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            <end position="1177"/>
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        <location>
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            <end position="1224"/>
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    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1230"/>
            <end position="1251"/>
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    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1263"/>
            <end position="1286"/>
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    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1386"/>
            <end position="1408"/>
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            <begin position="91"/>
            <end position="339"/>
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            <end position="1031"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023180"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS50893"/>
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    </evidence>
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            <dbReference type="EMBL" id="KAK4034192.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1421" mass="156238" checksum="A2E976A01FD7443E" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PBH6</accession>
    <name>A0AAN6PBH6_9PEZI</name>
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        <submittedName>
            <fullName evidence="3">Reticulocyte-binding protein 2 a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_39110</name>
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    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854481">
        <property type="protein sequence ID" value="KAK4034385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PBH6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24216:SF65">
        <property type="entry name" value="PAXILLIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24216">
        <property type="entry name" value="PAXILLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
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            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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            <end position="107"/>
        </location>
    </feature>
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            <end position="22"/>
        </location>
    </feature>
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        <location>
            <begin position="111"/>
            <end position="554"/>
        </location>
    </feature>
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            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
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        <location>
            <begin position="128"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
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            <end position="166"/>
        </location>
    </feature>
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            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
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            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
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        </location>
    </feature>
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            <end position="432"/>
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    </feature>
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        <location>
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            <end position="486"/>
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        <location>
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            <end position="500"/>
        </location>
    </feature>
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        <location>
            <begin position="530"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="772" mass="85250" checksum="5E9C1284707B6A92" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PBL9</accession>
    <name>A0AAN6PBL9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein YIP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_38155</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Golgi apparatus membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the YIP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854446">
        <property type="protein sequence ID" value="KAK4035365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PBL9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006977">
        <property type="entry name" value="Yip1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039765">
        <property type="entry name" value="Yip5/YIPF1/YIPF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12822">
        <property type="entry name" value="PROTEIN YIPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12822:SF2">
        <property type="entry name" value="PROTEIN YIPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04893">
        <property type="entry name" value="Yip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Yip1" evidence="8">
        <location>
            <begin position="101"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="37"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="50"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4035365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="293" mass="31679" checksum="540AC807100A0208" modified="2024-10-02" version="1">MSRSGYDAVVDVDDEGDLGHTDLQEDLEFHNSNFSETSPALGTGAGRNKSSTSPSLPLPATANTSASSQPGGKRFLWTLSFYAQFFDVDTSSVLHRCWAALYPRANFLDVLEGNPDLYGPFWIATTVVLILFLGGTISDYSAREGRGTFAYDFGLLSGAAGLIYGYTFVIPVVLYLALRYFGSESANLLECWALYGYGNLTWIPVALISWSPFAVLNWVFVGVGFGVSVAFLLRNLYPVLSATDRQTSKVLLILVVALHFGLAIAIKVLFFAHGSPALKDGGDKADPAPGRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PBY7</accession>
    <name>A0AAN6PBY7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_18666</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854475">
        <property type="protein sequence ID" value="KAK4034552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PBY7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="18"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4034552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="419" mass="45233" checksum="E77FE463DA9CCAB4" modified="2024-10-02" version="1">MTVSPPRPRPLEPALPPMPRRQSCDRCHEQKVRCVTEGLDGALILGGIAEQGDSKDGHVVSPVPCVRCRKAGAICIYSRNEVGLGIQEHPQESAYQHAAPQTTPLASPAATTPHYEQGTHHNLGLDTPPFTDHWQTPSYGSDGSQSLTDMCQVTSFSAAPTGPCVPLFPGPATNVVPTTAEHVMGNYSWCFPTSDYFLEELAQINLRIHLAGRALLLPARAPAPSPAVNDVFDAASSLINLVDSFASRRSLPPTNLPDTDRGAVNTALDSSTCLMIHACHQALLGAFEDLSSSLLHLSKPQRHTPPQTPDASFLPPCTTQAVAMTNLISHLLNQLDRAVLSLPGNFNLPPPRHHEHGTIPTSAAIFGHGQCEPPDLHPGHDTWRGNAALSLFSEMEERQMRVRGQVKAVERLLRQAHVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PC52</accession>
    <name>A0AAN6PC52_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Carbon-nitrogen hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_37874</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbon-nitrogen hydrolase superfamily. Nitrilase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854437">
        <property type="protein sequence ID" value="KAK4038171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PC52"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044149">
        <property type="entry name" value="Nitrilases_CHs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46044:SF12">
        <property type="entry name" value="HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46044">
        <property type="entry name" value="NITRILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="3">
        <location>
            <begin position="4"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="101"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="262"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="313"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="346"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="282"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="346"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4038171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="443" mass="47769" checksum="FBB3EC6F586D1C8B" modified="2024-10-02" version="1">MAPTTIRLGTASPGTQATTAETLAQLEHIARQAASKNIDILLLPEAYIGGYPRGTHFGCVIGSRTNEGREEYLRYFQSAVDLGDTVGDGAGAGQAWVNRELPSDAVPGSDGGNDAPNKRGDGTREELERISRDTGVFIVTGLIEKAGGSMYCSAVYVCPRLGIIGKRRKVMPTATERLVWAQGSPATLRAVSTTIRGVRINMAAAICWENYMPLLRQALYAQNINLYLAPTADGRDAWLSLLRTVAIEGRCFVLSSNMCVRSRPTPNGHPTNHPEEDEEKANGTTRDASPFTQPHAGTLHHRRRQSILDDDGNEIALACPPPPSKPRGRRQSIFDEDGNEIVLCKPTTTTTKPTTTTTTTTEPGPATAKSVFTSRGGSTIISPFGDVLAGPQWEDDSGTLTHADVDFADCIRGRLDLDTAGSYSRNDSFRLEVRGLDLAPLPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PC54</accession>
    <name>A0AAN6PC54_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Spindle pole body component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_17942</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytoskeleton</location>
            <location evidence="5">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TUBGCP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854446">
        <property type="protein sequence ID" value="KAK4035359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PC54"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF70">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="8">
        <location>
            <begin position="190"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="7">
        <location>
            <begin position="599"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="91"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="831"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="837"/>
            <end position="852"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4035359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="982" mass="107664" checksum="652093347A76D5AE" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PCA1</accession>
    <name>A0AAN6PCA1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_17907</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the anthrone oxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854444">
        <property type="protein sequence ID" value="KAK4035434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PCA1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013901">
        <property type="entry name" value="Anthrone_oxy"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35042">
        <property type="entry name" value="ANTHRONE OXYGENASE ENCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35042:SF1">
        <property type="entry name" value="DUF1772-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08592">
        <property type="entry name" value="Anthrone_oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4035434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="154" mass="16735" checksum="BC7725BA36583F6B" modified="2024-10-02" version="1" fragment="single">TPNPTTKLLARQWLALYQLGPVWVPPLIHTGILSNLFLSFIHPSERNLYLLAAALTFSILPFTFLYLEPGINGACKWKVAGLLQDEGFAMPGRKKGLVKPSVVRHSASESSKKWAEGVEMGVLVEAWAGRNHVRWVVGVGAGVVSFLAMGRGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PCC3</accession>
    <name>A0AAN6PCC3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA polymerase delta subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_49999</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854532">
        <property type="protein sequence ID" value="KAK4033407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PCC3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043625">
        <property type="term" value="C:delta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1030.20">
        <property type="entry name" value="DNA polymerase delta, p66 (Cdc27) subunit, wHTH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008313">
        <property type="entry name" value="GH125"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019038">
        <property type="entry name" value="POLD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041913">
        <property type="entry name" value="POLD3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31047">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 157 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31047:SF0">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 157 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09507">
        <property type="entry name" value="CDC27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06824">
        <property type="entry name" value="Glyco_hydro_125"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01149">
        <property type="entry name" value="DUF1237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="183"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="219"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4033407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="909" mass="100440" checksum="E900087D111607C5" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PCL8</accession>
    <name>A0AAN6PCL8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_17457</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854428">
        <property type="protein sequence ID" value="KAK4038477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PCL8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42032">
        <property type="entry name" value="YALI0E30679P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42032:SF1">
        <property type="entry name" value="YALI0E30679P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="447"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="491"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4038477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="512" mass="56386" checksum="9614BA75721B40C0" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PD60</accession>
    <name>A0AAN6PD60_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tho complex subunit 7-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_17202</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854420">
        <property type="protein sequence ID" value="KAK4038726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PD60"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008501">
        <property type="entry name" value="THOC7/Mft1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05615">
        <property type="entry name" value="THOC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="35"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="237"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="62"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="295"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="318"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="339"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4038726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="389" mass="42475" checksum="1BC4DE50B3F67EED" modified="2024-10-02" version="1">MTPWGLLDDKEEIELHKSRLLNVEEKPFKRITKRLNTLHSLTTARARQAPTPPPETNGTPHQQQQSQTTSANAQQQQRDGTPAAAAAAEGAPDLAQLKEDVTIDFAAFDSSIARLQFLLTANGRERERYAAERGRIVATSQAVRDSTGQLRAQLEQARATLAQRREFDALADAITSRAALRPRAEQAANLTKLRDEIAELEAEREAYGVTWHERREQFARIMEESMRLRRLIRDEKEEVERREGMDDDEGGGTPRPSGMGSREGTPRPDGGLAPKTDSGDAVGTPRPVSVGGRTPARDSPAHDSRSFTAKRTTILDASFSQVGSQMGSREGSADRETQGEAEEGEDVEMGETGEAKGDESEPDSPLTPPPADDTPQIVVNGEGDSMDTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PDH9</accession>
    <name>A0AAN6PDH9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_48911</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854466">
        <property type="protein sequence ID" value="KAK4034763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PDH9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042848823" description="Ig-like domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4034763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="508" mass="53584" checksum="089B4C5B7EAF3936" modified="2024-10-02" version="1">MARLLSLTALAAVLAPAAGNVFALAQLTAGCTSSSFTTPSWLVQDLRSQTSANLTVASFHALNRATNVSLELRCTSSTPTAGWQSCRARNQTEQSLVAAFQADTSTAWFLFNETWSCSDVTPSKPLTFSALGNSSVALNCTTDTSTTTTCHSTKPLLVKATLASPVKITPSYVSGPLGHDTKGCTAQSRTPAWEVAASQINLRKVSGVLQAGNVFVIIRNDHLGYTASCGGVLTGASGPQPLTCEGQLAYRRPDKYQIDTVLSFAPETFELAVNQTWFCDDQDPAQPVSITASGTTPLSVECQVFNGTAPTDTTTFCSGGTNGTFAGNTTSRALLQPYSLNDPLPTADSCTISSILSPAWWFNGFETNTTTNNNQVVTAQFGMELQTGGTQSTGNFAIVAADGVVDATPSGTNSSAELPWNTCVLQSVGDAALAPTGCEFRYDMASRFLGLRVQWACADLDRGSPITFSGEVRTLVPDLTCVTSGTRIRCAASDPQPWRANVTSVTWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PDJ8</accession>
    <name>A0AAN6PDJ8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fork-head domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_37037</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854413">
        <property type="protein sequence ID" value="KAK4038987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PDJ8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045912">
        <property type="entry name" value="FOXJ2/3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46078:SF2">
        <property type="entry name" value="FORK-HEAD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46078">
        <property type="entry name" value="FORKHEAD BOX PROTEIN J2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Fork-head" evidence="7">
        <location>
            <begin position="235"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="5">
        <location>
            <begin position="235"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="80"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="147"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="269"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="334"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="427"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="277"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="300"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="344"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="363"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="385"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="395"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="437"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4038987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="602" mass="65571" checksum="C8571DDECB560DEF" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PDU6</accession>
    <name>A0AAN6PDU6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Heat shock factor binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_37275</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HSBP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854419">
        <property type="protein sequence ID" value="KAK4038787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PDU6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070370">
        <property type="term" value="P:cellular heat acclimation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.430:FF:000006">
        <property type="entry name" value="Heat shock factor binding 1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009643">
        <property type="entry name" value="HS1-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19424">
        <property type="entry name" value="HEAT SHOCK FACTOR BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19424:SF0">
        <property type="entry name" value="HEAT SHOCK FACTOR BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06825">
        <property type="entry name" value="HSBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="42"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4038787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="74" mass="7975" checksum="353D2842C2943BAF" modified="2024-10-02" version="1">MASKNDPPAAQPANTNDDARSELTAQVEDLLNTLSNKFAGVSSEIFAKMDEMSRRLDNLETQLTASKDKSSGSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PEB1</accession>
    <name>A0AAN6PEB1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_47166</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854402">
        <property type="protein sequence ID" value="KAK4039377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PEB1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="339"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4039377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="379" mass="42398" checksum="D9D6A0FEE3B1C0CF" modified="2024-10-02" version="1">MTFKASNVLKSSAAPVLDKMDTAQDKRHGLLAIFAVLCWVTASLEPVLEKAAPCAALHLTALNSARRYTARDTRRPLSKMFYSFRESALPAMEWQGGQADSGLASGNPSPGPLPSHARGADDDILYESSLNYFTLRTIGRVKLKWVDTLTAHLAFDRSTRTLSLFRYPSFCVANLLRTNDVAVLRRITSKLLSSHYYDDGSPEEPAAVYREILLSYRLLFGQSSKSRRLFVQLLNRQPAAGDEAMDAPQRDPFLSVICASPLTSLWRREKNISALPGSLSPPPVLGLDDQLQEAPTYSARDNFPIFGPRLLRLQRYSLRQQPSKMRDLWRDRRNPLQWYTFWAVFLVGGVSILLSVLQLVVGVSQLYFAIRSLDSSAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PF69</accession>
    <name>A0AAN6PF69_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Poly [ADP-ribose] polymerase</fullName>
            <shortName evidence="15">PARP</shortName>
            <ecNumber evidence="15">2.4.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">C8A01DRAFT_17076</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>NAD(+) + (ADP-D-ribosyl)n-acceptor = nicotinamide + (ADP-D-ribosyl)n+1-acceptor + H(+).</text>
            <dbReference type="EC" id="2.4.2.30"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the ARTD/PARP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.-" evidence="15"/>
    <dbReference type="EMBL" id="MU854417">
        <property type="protein sequence ID" value="KAK4038865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ poly-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990404">
        <property type="term" value="F:NAD+-protein mono-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070212">
        <property type="term" value="P:protein poly-ADP-ribosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17747">
        <property type="entry name" value="BRCT_PARP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd01437">
        <property type="entry name" value="parp_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07997">
        <property type="entry name" value="WGR_PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.142.10:FF:000002">
        <property type="entry name" value="Poly [ADP-ribose] polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.140.10:FF:000001">
        <property type="entry name" value="Poly [ADP-ribose] polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.142.10">
        <property type="entry name" value="Poly(ADP-ribose) polymerase, regulatory domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.140.10">
        <property type="entry name" value="WGR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050800">
        <property type="entry name" value="ARTD/PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012317">
        <property type="entry name" value="Poly(ADP-ribose)pol_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004102">
        <property type="entry name" value="Poly(ADP-ribose)pol_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036616">
        <property type="entry name" value="Poly(ADP-ribose)pol_reg_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036930">
        <property type="entry name" value="WGR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008893">
        <property type="entry name" value="WGR_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10459">
        <property type="entry name" value="DNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10459:SF60">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00644">
        <property type="entry name" value="PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02877">
        <property type="entry name" value="PARP_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05406">
        <property type="entry name" value="WGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00773">
        <property type="entry name" value="WGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47587">
        <property type="entry name" value="Domain of poly(ADP-ribose) polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142921">
        <property type="entry name" value="WGR domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51060">
        <property type="entry name" value="PARP_ALPHA_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51059">
        <property type="entry name" value="PARP_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51977">
        <property type="entry name" value="WGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0013">ADP-ribosylation</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 15" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 15" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BRCT" evidence="18">
        <location>
            <begin position="12"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="WGR" evidence="21">
        <location>
            <begin position="230"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="PARP alpha-helical" evidence="20">
        <location>
            <begin position="359"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="PARP catalytic" evidence="19">
        <location>
            <begin position="494"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="17">
        <location>
            <begin position="732"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="17">
        <location>
            <begin position="790"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="97"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="330"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="829"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="160"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="192"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="332"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="860"/>
            <end position="871"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00033987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU362114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAK4038865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1445" mass="156743" checksum="B4CAA2804A433A43" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PF92</accession>
    <name>A0AAN6PF92_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_46962</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854396">
        <property type="protein sequence ID" value="KAK4039632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PF92"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="170"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4039632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="319" mass="34165" checksum="EF504F7A63A43EB5" modified="2024-10-02" version="1">MPRRTKKPPRPVYHDGLIPATHDTYQSYPEIVPDDHDQIKHEKSYPELAPPQPDPESQQQQQTQQQQQSPEQRQHHHHHPSISTTTGIIPPPTAHSTHHHHHPLSGFPAGINPSPLSAPPIIHPLSRTSGVHSLRQAWSEVDDDEPRDGEGGRRHEFLDEQRPVLWKRPIFWVVVVAGAVIVALAGVLGGVASGGIKTAWDSSSRTSGGSTTTTSTPSVTDPTCPGSANLNYTSSATTSPKTFRIQCAANYPDGDGDLGLVEDAVDSIAGCLDACAQEASCVGAVFKQGDAAKCWLKQFIGVVQTGGAAGGMVSGVLWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PFX9</accession>
    <name>A0AAN6PFX9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_18014</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854449">
        <property type="protein sequence ID" value="KAK4035282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PFX9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20558">
        <property type="entry name" value="CYCLIN_ScPCL7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF117">
        <property type="entry name" value="PHO85 CYCLIN PHO80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4035282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="410" mass="43276" checksum="40E1337FB2068F2F" modified="2024-10-02" version="1">MLARSPVPTANPANASPRSSFHSFHYAPAPSPRYPSPRLAADAKSRRPPNSPAPAPAPAIAPSSAAPPTRYVAVDAATQYSPMEPMDYATGALLPRVPPPATDPHPSTAPKTMAADDERPAVAAPPLARPSKPVPPGPKQRIEAPFSPTSPSKRRNSQGPGSLSALATDPLQNPSTLAKRAKPDTAPPKILPLRYEHCAVEDVVVLIAHMLGELIETNDTLALKSGHLTRFHSRTAPGISVLDYLNRLAKHATLTPPLLLSMVYYIDRLCALYPDFTINTLTVHRFLITAATVAAKGLSDAFWNNSTYARVGGVKLAELKLLELEFLHRVDWKIVPNPEVLVAYYAGLVERCPRYTLEGAENGGDDAAGDSEALDDSDELDDDDAVEGEQGAVSAGGTAGAGGAPSLGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PFY9</accession>
    <name>A0AAN6PFY9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Acetolactate synthase</fullName>
            <ecNumber evidence="4 12">2.2.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">C8A01DRAFT_46393</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2 pyruvate + H(+) = (2S)-2-acetolactate + CO2</text>
            <dbReference type="Rhea" id="RHEA:25249"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="2.2.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="12">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="12">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.6" evidence="4 12"/>
    <dbReference type="EMBL" id="MU854381">
        <property type="protein sequence ID" value="KAK4040233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PFY9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005948">
        <property type="term" value="C:acetolactate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02015">
        <property type="entry name" value="TPP_AHAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07035">
        <property type="entry name" value="TPP_PYR_POX_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000008">
        <property type="entry name" value="Acetolactate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000007">
        <property type="entry name" value="Acetolactate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000053">
        <property type="entry name" value="Acetolactate synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012846">
        <property type="entry name" value="Acetolactate_synth_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039368">
        <property type="entry name" value="AHAS_TPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00118">
        <property type="entry name" value="acolac_lg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968:SF13">
        <property type="entry name" value="ACETOLACTATE SYNTHASE CATALYTIC SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="THIAMINE PYROPHOSPHATE ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="8 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 12" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="16">
        <location>
            <begin position="95"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="14">
        <location>
            <begin position="293"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="15">
        <location>
            <begin position="503"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="34"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAK4040233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="695" mass="75813" checksum="DB93E22B843B5224" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PG43</accession>
    <name>A0AAN6PG43_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_37711</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854432">
        <property type="protein sequence ID" value="KAK4038324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP001303115">
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    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MFS_dom"/>
    </dbReference>
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        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
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        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05010)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="96"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="247"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="416"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="436"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="464"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="516"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="562"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="96"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="12"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="74"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
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            <dbReference type="EMBL" id="KAK4038324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="651" mass="70188" checksum="00F610717E15824E" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PHY8</accession>
    <name>A0AAN6PHY8_9PEZI</name>
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        <submittedName>
            <fullName evidence="9">Cation transport protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_14898</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
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            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854359">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PHY8"/>
    <dbReference type="Proteomes" id="UP001303115">
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:high-affinity potassium ion transmembrane transporter activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Cat_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051143">
        <property type="entry name" value="TrkH_K-transport"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064">
        <property type="entry name" value="POTASSIUM TRANSPORT PROTEIN DDB_G0292412-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064:SF37">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02386">
        <property type="entry name" value="TrkH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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        </location>
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        </location>
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            <end position="239"/>
        </location>
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        </location>
    </feature>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="794" mass="87220" checksum="07470E95CD62CEC4" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PI04</accession>
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        <recommendedName>
            <fullName evidence="4">DUF1308 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">C8A01DRAFT_15069</name>
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        <name type="scientific">Parachaetomium inaequale</name>
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            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PI04"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="UNCHARACTERIZED DUF1308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13379:SF0">
        <property type="entry name" value="UPF0415 PROTEIN C7ORF25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="578"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="581"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="602"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4041102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="611" mass="67171" checksum="B2B6D215D8C87D5F" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PIT8</accession>
    <name>A0AAN6PIT8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_34490</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854356">
        <property type="protein sequence ID" value="KAK4041537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PIT8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042913876" description="Secreted protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4041537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="234" mass="24914" checksum="DBCBC815F07DAF48" modified="2024-10-02" version="1" fragment="single">MNTAIVVLSISTLVLAGSRALLADVLSSTPPSTAIGIPADKAVAKVIDEIVNPVLDTSGADTPPFSRQSPPHRHQQCRRQRARPLAAATNPNAQWTEGVEDIQWRIVGVLPSLLRGLGLVCPKCKAEGERIAKGNHSATAKSASGAALPCARTCLGFLAQGCWNRAFLVVPCGGTLDDPRFRELVFRVALPAMTHMSKVAAEVATMEWVRRDTAIPVPDVLAYASGRDNDVGYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PJ34</accession>
    <name>A0AAN6PJ34_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_34983</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854365">
        <property type="protein sequence ID" value="KAK4041038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PJ34"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF35">
        <property type="entry name" value="ACID TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="374"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="423"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="453"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="515"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="543"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="7">
        <location>
            <begin position="58"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4041038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="618" mass="68860" checksum="2937B0D12C24D71B" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PJE4</accession>
    <name>A0AAN6PJE4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">7-dehydrocholesterol reductase</fullName>
            <ecNumber evidence="16">1.3.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Sterol Delta(7)-reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">C8A01DRAFT_34118</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 18">Belongs to the ERG4/ERG24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.21" evidence="16"/>
    <dbReference type="EMBL" id="MU854350">
        <property type="protein sequence ID" value="KAK4041867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PJE4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047598">
        <property type="term" value="F:7-dehydrocholesterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016132">
        <property type="term" value="P:brassinosteroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006695">
        <property type="term" value="P:cholesterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001171">
        <property type="entry name" value="ERG24_DHCR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257:SF38">
        <property type="entry name" value="7-DEHYDROCHOLESTEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01222">
        <property type="entry name" value="ERG4_ERG24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0152">Cholesterol biosynthesis</keyword>
    <keyword evidence="4" id="KW-0153">Cholesterol metabolism</keyword>
    <keyword evidence="3 18" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12 18" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="10 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 18" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="15 18" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="11 18" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="14 18" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="5 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00038851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00042688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU369120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAK4041867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="113" mass="12731" checksum="4848BD19CB2CB89D" modified="2024-10-02" version="1">MSCRFFETLDGAHERFSFYSVFGFAVMMPHLWTLQTQYLASHPVQLSTPPVVLLVIGFAAGWTLNHIANDQKNISRRTEGKFRIAGQEVETVEAKYQTADGKIHRTVLLCSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PJN0</accession>
    <name>A0AAN6PJN0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA mismatch repair protein PMS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_45629</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854362">
        <property type="protein sequence ID" value="KAK4041190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PJN0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032389">
        <property type="term" value="C:MutLalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000710">
        <property type="term" value="P:meiotic mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16926">
        <property type="entry name" value="HATPase_MutL-MLH-PMS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03484">
        <property type="entry name" value="MutL_Trans_hPMS_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.100:FF:000001">
        <property type="entry name" value="Mismatch repair endonuclease pms1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000014">
        <property type="entry name" value="Mismatch repair endonuclease pms1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000120">
        <property type="entry name" value="Mismatch repair endonuclease PMS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.20">
        <property type="entry name" value="MutL, C-terminal domain, dimerisation subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.100">
        <property type="entry name" value="MutL, C-terminal domain, regulatory subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014762">
        <property type="entry name" value="DNA_mismatch_repair_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002099">
        <property type="entry name" value="MutL/Mlh/PMS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014790">
        <property type="entry name" value="MutL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042120">
        <property type="entry name" value="MutL_C_dimsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042121">
        <property type="entry name" value="MutL_C_regsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037198">
        <property type="entry name" value="MutL_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00585">
        <property type="entry name" value="mutl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF52">
        <property type="entry name" value="MISMATCH REPAIR ENDONUCLEASE PMS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08676">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00853">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118116">
        <property type="entry name" value="DNA mismatch repair protein MutL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00058">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein S5" evidence="6">
        <location>
            <begin position="220"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="MutL C-terminal dimerisation" evidence="5">
        <location>
            <begin position="871"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="374"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="828"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1086"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="387"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="421"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="454"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="474"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="661"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="705"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="741"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="762"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="788"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="1086"/>
            <end position="1095"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00070941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4041190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1107" mass="120402" checksum="4FE2071A892CBFB7" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PK58</accession>
    <name>A0AAN6PK58_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cyclin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_35476</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family. Cyclin AB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854375">
        <property type="protein sequence ID" value="KAK4040529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PK58"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044772">
        <property type="term" value="P:mitotic cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20568">
        <property type="entry name" value="CYCLIN_CLBs_yeast_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20512">
        <property type="entry name" value="CYCLIN_CLBs_yeast_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000001">
        <property type="entry name" value="G2/mitotic-specific cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000005">
        <property type="entry name" value="G2/mitotic-specific cyclin B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046965">
        <property type="entry name" value="Cyclin_A/B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001771">
        <property type="entry name" value="Cyclin_A_B_D_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 5" id="KW-0195">Cyclin</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="7">
        <location>
            <begin position="258"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="8">
        <location>
            <begin position="351"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="7">
        <location>
            <begin position="355"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="141"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="153"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4040529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="487" mass="54803" checksum="5C88EF6129A2BA19" modified="2024-10-02" version="1">MPVRTRNPRSVTNENDENSNATARVTRAKAAATLNVDELAMPTKALQSKKTTANANPARRRAALGDVSNVAKVEAAESKKPVGRTGLVSKAAQPIGVQKKSTTTRSALTTKEVNKKVETKRSGPGSIVAQKRKVLNTVSSNTVVKEDTPEEGEPIRKKVHTLEGDKKIKTDVKQQEPARKDAAQSPAPVASEPDLRAETPEAARLLDSEDLDDPLMVAEYANDIFEYLRDLECNSVPNPQYMSHQDDLEWKTRGILIDWLVEVHTRFHLLPETLFLAVNVVDRFLSEKVVQLDRLQLVGITAMFIASKYEEVLSPHIANFRHIADDGFTEAEILSAERFVLATLNYDLSYPNPMNFLRRISKADNYDIQSRTIGKYLMEISLLDHRLMAYRPSHIAAAAMYLSRLVLDRGEWDETLEYYAGYSEEEIQPVVMLMVDYMARPVIHEAFFKKYASKKFLKASILTRQWSKKNAHLYGITDIDLTLDEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PKU4</accession>
    <name>A0AAN6PKU4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Histidine--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="3">6.1.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Histidyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">C8A01DRAFT_33355</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the aminoacylation of histidyl-tRNA in both the cytoplasm and the mitochondrion.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(His) + L-histidine + ATP = L-histidyl-tRNA(His) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17313"/>
            <dbReference type="Rhea" id="RHEA-COMP:9665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9689"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78527"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.21"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.21" evidence="3"/>
    <dbReference type="EMBL" id="MU854339">
        <property type="protein sequence ID" value="KAK4042552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PKU4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004821">
        <property type="term" value="F:histidine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006427">
        <property type="term" value="P:histidyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00773">
        <property type="entry name" value="HisRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00859">
        <property type="entry name" value="HisRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000015">
        <property type="entry name" value="Histidyl-tRNA synthetase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000021">
        <property type="entry name" value="Probable histidine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00127">
        <property type="entry name" value="His_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015807">
        <property type="entry name" value="His-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004516">
        <property type="entry name" value="HisRS/HisZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033656">
        <property type="entry name" value="HisRS_anticodon"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11476:SF7">
        <property type="entry name" value="HISTIDINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11476">
        <property type="entry name" value="HISTIDYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001549">
        <property type="entry name" value="His-tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="16">
        <location>
            <begin position="15"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="305"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="84"/>
            <end position="86"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="286"/>
            <end position="287"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00058343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00067413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001549-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAK4042552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="529" mass="58545" checksum="57149CDAE89D9A08" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PL00</accession>
    <name>A0AAN6PL00_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_13637</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854336">
        <property type="protein sequence ID" value="KAK4042737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PL00"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="364"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="415"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="227"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="373"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="448"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="463"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4042737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="787" mass="87053" checksum="BAD8CCE5FC19E09D" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PLV2</accession>
    <name>A0AAN6PLV2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cyanovirin-N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_14968</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854360">
        <property type="protein sequence ID" value="KAK4041266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PLV2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.60.10">
        <property type="entry name" value="Cyanovirin-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011058">
        <property type="entry name" value="Cyanovirin-N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036673">
        <property type="entry name" value="Cyanovirin-N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08881">
        <property type="entry name" value="CVNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51322">
        <property type="entry name" value="Cyanovirin-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042942896" description="Cyanovirin-N domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Cyanovirin-N" evidence="2">
        <location>
            <begin position="22"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4041266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="128" mass="13180" checksum="642A4EA382896BFE" modified="2024-10-02" version="1">MKSILSVLVLGLGATGALAANFAGSCDANSIKVEGRTLTANCKNIFGQLKCSKLDLNRCLKNSYGTLQADASGAGPHLDQCVQCTNGKPDNGLIVDAGPSLMYCKCNPGTGAAQANWPTAIFDLSQCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PM32</accession>
    <name>A0AAN6PM32_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="6">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">C8A01DRAFT_13845</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 23">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Lysosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="6"/>
    <dbReference type="EMBL" id="MU854339">
        <property type="protein sequence ID" value="KAK4042555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PM32"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070936">
        <property type="term" value="P:protein K48-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16489">
        <property type="entry name" value="mRING-CH-C4HC2H_ZNRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051878">
        <property type="entry name" value="ZNRF_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46661">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE ZNRF1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46661:SF4">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0967">Endosome</keyword>
    <keyword evidence="16" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="15" id="KW-0458">Lysosome</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0519">Myristate</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <keyword evidence="11 17" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="20">
        <location>
            <begin position="271"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="19">
        <location>
            <begin position="594"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="84"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="352"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="545"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="373"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="399"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="18">
        <location>
            <begin position="545"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="555"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="21">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAK4042555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="642" mass="68681" checksum="C7E7C2C87EE848A0" modified="2024-10-02" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PMU8</accession>
    <name>A0AAN6PMU8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">C8A01DRAFT_34578</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854358">
        <property type="protein sequence ID" value="KAK4041380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PMU8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1070">
        <property type="entry name" value="Translation initiation factor eIF-2B, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051501">
        <property type="entry name" value="eIF2B_alpha/beta/delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042528">
        <property type="entry name" value="elF-2B_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45860">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45860:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="20"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK4041380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="367" mass="39905" checksum="960212AB544116F0" modified="2024-10-02" version="1">MTTDGPSKPASAAAATTQQLPVRTNSTSSSSQRENGGAFDIVRTYHEHLNSDRELTMGVAAIESLIELLRNTSSSTAMELVEIVKKEKAKLLASAPNPLPLLAGADLFEQYLLRSLRGPAATATGGSGPDRVLSFDETRQHLLDNKDLFAQRAKADRDSIAIWGSRYVSDRCIVLTAGGSRTVTKILLRAAADMSKHFKVIYIVDGHNRRSDVAVAQLREAGVEVETISPHKVAYVLGNQKQINLVLVGTEVVMQNGGIISGMGTAQLAHLTKTVKGGIKRFYVAAETHKICRKTPIAYPMVNRVGVRQKDISKFDNVGVDLSEEVPGMVAEQDEVDYTDPELIDGIITEQGVKMASQIWEMVDDYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PN02</accession>
    <name>A0AAN6PN02_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Alpha-1,3-glucosyltransferase</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">C8A01DRAFT_12544</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the second glucose residue from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide intermediate Glc(1)Man(9)GlcNAc(2)-PP-Dol to produce Glc(2)Man(9)GlcNAc(2)-PP-Dol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>an alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl beta-D-glucosyl phosphate = an alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31307"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19502"/>
            <dbReference type="Rhea" id="RHEA-COMP:19521"/>
            <dbReference type="Rhea" id="RHEA-COMP:19522"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57525"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:132521"/>
            <dbReference type="ChEBI" id="CHEBI:132522"/>
            <dbReference type="EC" id="2.4.1.265"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:31308"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the ALG6/ALG8 glucosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="EMBL" id="MU854322">
        <property type="protein sequence ID" value="KAK4043976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PN02"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042283">
        <property type="term" value="F:dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004856">
        <property type="entry name" value="Glyco_trans_ALG6/ALG8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413">
        <property type="entry name" value="DOLICHYL GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413:SF2">
        <property type="entry name" value="DOLICHYL PYROPHOSPHATE GLC1MAN9GLCNAC2 ALPHA-1,3-GLUCOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03155">
        <property type="entry name" value="Alg6_Alg8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="318"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="408"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="447"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="473"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK4043976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="501" mass="56510" checksum="46BDF9DCDADCFAEA" modified="2024-10-02" version="1">MTEIYPSLAQCAVVAAALKILLFPAYKSTDFEVHRNWLAITNSLPLWGWYYEKSSEWTLDYPPFFAYFEWIMSQVAKLVDPAMLKVYNLEYDSWQTIYFQRFTVIVTELLLVYALQMFVDSSHGASKRAAQAAAISILLSPGLLIIDHIHFQYNGAMYGLLIASLVLARKNSTLLWSGLLFAALLCMKHIYLYLAPAYFVFLLRAYCLSPKSVFRIQFLNCVKLGAGIAAIFGTAFGPFALKGQIPQIFSRLFPFSRGLCHAYWAPNVWAMYSFVDRVLIILAPRLGLAVKEEALQSVTRGLVGDTSFAILPDVTPRVCFALTLFFQAIPLLKLFAQPTWDNFIGAVTLCGYASFLFGWHVHEKAVLLVIIPFSLIALRDRRYLGAFRPLAVAGHVSLFPLLFTPAEFPIKTVYTVFWLILFLMAFDRLAPASSRARFFLFDRFSTLYITVSIPLIVYCSLVHGVAFGKSYEFLPLMFTSSYSAIGVVGSWVGFVVVYFTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PNE1</accession>
    <name>A0AAN6PNE1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thiaminase-2/PQQC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_12457</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854321">
        <property type="protein sequence ID" value="KAK4044171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PNE1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006772">
        <property type="term" value="P:thiamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19357">
        <property type="entry name" value="TenA_E_At3g16990-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053261">
        <property type="entry name" value="Polyketide-peptide_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004305">
        <property type="entry name" value="Thiaminase-2/PQQC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41813">
        <property type="entry name" value="REGULATOR PAB1642, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11955)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41813:SF2">
        <property type="entry name" value="REGULATOR PAB1642, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11955)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03070">
        <property type="entry name" value="TENA_THI-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thiaminase-2/PQQC" evidence="1">
        <location>
            <begin position="21"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4044171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="310" mass="34055" checksum="984FCB57FFB4E927" modified="2024-10-02" version="1">MASSGGTVNWSLTDHLLATQEHLYKSATQHPFLLAGAEGRLPKDILSHWLSNDRLYIHAYLRAAGNLLASIDLPKQVPGSQEAFETQLADWVIEALVAIRKEERFFIDVAERYDLGIEIALPSLPAQASTQDATSKDTTHGGKLPGLVQMESIFASVGAPRQTSPDSPSKVPGVALVQPLFTTTAAANTPPTLLPWLEGALTFWGTERCYLGAWSWARGKAEERRSSGEHAEEKDADGGALRKEFIPNWSSPEFAQFVDKLGKLIDDSVAAVLEGKEGEERERIKAGILARVEGKWRTLLEAERQFWPDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PNE6</accession>
    <name>A0AAN6PNE6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Ornithine aminotransferase</fullName>
            <ecNumber evidence="4 9">2.6.1.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">C8A01DRAFT_32562</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 2-oxocarboxylate + L-ornithine = L-glutamate 5-semialdehyde + an L-alpha-amino acid</text>
            <dbReference type="Rhea" id="RHEA:13877"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="ChEBI" id="CHEBI:59869"/>
            <dbReference type="EC" id="2.6.1.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-ornithine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.13" evidence="4 9"/>
    <dbReference type="EMBL" id="MU854329">
        <property type="protein sequence ID" value="KAK4043245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PNE6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004587">
        <property type="term" value="F:ornithine aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019544">
        <property type="term" value="P:L-arginine catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010121">
        <property type="term" value="P:L-arginine catabolic process to proline via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000011">
        <property type="entry name" value="Ornithine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000152">
        <property type="entry name" value="Ornithine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050103">
        <property type="entry name" value="Class-III_PLP-dep_AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010164">
        <property type="entry name" value="Orn_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01885">
        <property type="entry name" value="Orn_aminotrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986">
        <property type="entry name" value="AMINOTRANSFERASE CLASS III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986:SF18">
        <property type="entry name" value="ORNITHINE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9 11" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK4043245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="448" mass="48091" checksum="6C2E2F3940A5167D" modified="2024-10-02" version="1">MAPHADNASPVRRGDTAPSKDRYHAASTKSAIAAENEFAAHNYHPLPVVFARAQGVHVWDPEGKHYLDFLSAYSAVNQGHCHPELIKALTAQAGRLTLSSRAFHNDVFPVWAEKVRQLFGFDMVLPMNTGAEAVETAVKIARKWAYKVKGVAPGKALVFGASDNFHGRTMTAISLSLDPESRDNYGPYVPNVGATNPTTGAPIRYNNLADLEAVLDAHGCDTAAFIVEPIQGEAGVVVPDDDYLARAHALCKRHNVLLICDEIQTGIARTGKMLCSEWAGIKPDMVTLGKAISGGMYPVSCVLADEAVMGVIEPGTHGSTYGGNPLGCAVSIRALELVEEEGLVDKAERLGRVFREGVEAFKSPVVQTVRGKGLLNAIVIDETKAAGRTAWELCLLLKEKGVLAKPTHGNIIRFAPPLVITEEELRGAIKTIGEALKELPTVEKSEGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PNK4</accession>
    <name>A0AAN6PNK4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lipopolysaccharide core heptose(II) kinase RfaY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_45115</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854351">
        <property type="protein sequence ID" value="KAK4041785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PNK4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4041785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="229" mass="25861" checksum="63C8B9AF7E35AFE4" modified="2024-10-02" version="1">MNLLSSRKFHLSPFINGENKDFWFRTRYIPALAARLSQQHPHVLELHLRPSTVASVIGSCVGLLPTFAQSWVKAAFPEWFLPSHVVLKKQKKGEGEEETIREEQFDTDVKAYDQLKPLQGTVIPTCYGRLRYDGTRALLLEYLGGVSMSLPEGTTLTLEELSALLQPCYEVLNAFSVHHDNPNLSNFQLVNGKIMALDLESAVFDMSADRRAYRGMQAYYRHDGSLEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PNT9</accession>
    <name>A0AAN6PNT9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Vps53-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_33756</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VPS53 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854344">
        <property type="protein sequence ID" value="KAK4042256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PNT9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.110">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 53, C-terminus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039766">
        <property type="entry name" value="Vps53"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031745">
        <property type="entry name" value="Vps53_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038260">
        <property type="entry name" value="Vps53_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007234">
        <property type="entry name" value="Vps53_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12820:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 53 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12820">
        <property type="entry name" value="VACUOLAR SORTING PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16854">
        <property type="entry name" value="VPS53_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04100">
        <property type="entry name" value="Vps53_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vps53 N-terminal" evidence="8">
        <location>
            <begin position="15"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="Vps53 C-terminal" evidence="9">
        <location>
            <begin position="610"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="630"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="633"/>
            <end position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4042256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="862" mass="94547" checksum="036C17386F78C38A" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PPB3</accession>
    <name>A0AAN6PPB3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glycoside hydrolase 131 catalytic N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_11938</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854317">
        <property type="protein sequence ID" value="KAK4044739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PPB3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041524">
        <property type="entry name" value="GH131_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34612">
        <property type="entry name" value="GH131_N DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34612:SF6">
        <property type="entry name" value="GLYCOSIDE HYDROLASE 131 CATALYTIC N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18271">
        <property type="entry name" value="GH131_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042837809" description="Glycoside hydrolase 131 catalytic N-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase 131 catalytic N-terminal" evidence="2">
        <location>
            <begin position="18"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4044739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="262" mass="29147" checksum="75FB9AB9CCE47EAB" modified="2024-10-02" version="1">MKAASLLAALAASVDGAVLWDGRFNDFSSSKDLNTWSWSNQVGPYQYYIHGSGTVEKYVNLSPDYKNPADAVSKQGAKFTLDSTAFWNGQNMRRTELIPQTKAAINKGKVYYHFSMMRKDTNAPSVNREHQICFFESHFTEMKYGWISGESGTSNANLQWMTNQQSRWKTEWKAGVWHNIAYEIDFSANKVGFWHSEGAEPLKQVVAPVSVSTSSNGADWHLGVLELPRSGYADANEDFYFSGVYVEDGTITTAVGGPGKSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PPK8</accession>
    <name>A0AAN6PPK8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitotic-spindle organizing protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Mitotic-spindle organizing protein associated with a ring of gamma-tubulin 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_33629</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for gamma-tubulin complex recruitment to the microtubule organizing center (MTOC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the gamma-tubulin complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Spindle pole body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MOZART1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854343">
        <property type="protein sequence ID" value="KAK4042280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PPK8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000931">
        <property type="term" value="C:gamma-tubulin ring complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031021">
        <property type="term" value="C:interphase microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033566">
        <property type="term" value="P:gamma-tubulin complex localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051415">
        <property type="term" value="P:microtubule nucleation by interphase microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090307">
        <property type="term" value="P:mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022214">
        <property type="entry name" value="MZT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28520">
        <property type="entry name" value="MITOTIC-SPINDLE ORGANIZING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28520:SF2">
        <property type="entry name" value="MITOTIC-SPINDLE ORGANIZING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12554">
        <property type="entry name" value="MOZART1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4042280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="84" mass="9068" checksum="0C76A5060FD622F1" modified="2024-10-02" version="1">MPPTERAEKQAAAQQAVDILHEIATILNCHLDRRTLSICISMIENGINPEALANVVKELRKQGQEVQLETAAAAAAAAAPARRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PQ16</accession>
    <name>A0AAN6PQ16_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Organic solute transporter Ostalpha-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_13574</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854335">
        <property type="protein sequence ID" value="KAK4042856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PQ16"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005178">
        <property type="entry name" value="Ostalpha/TMEM184C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23423">
        <property type="entry name" value="ORGANIC SOLUTE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03619">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01417">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="252"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="365"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="442"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="442"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="520"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="563"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4042856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="596" mass="66509" checksum="3F34D8110B7B6EAA" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PQE2</accession>
    <name>A0AAN6PQE2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">C8A01DRAFT_31612</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854320">
        <property type="protein sequence ID" value="KAK4044295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PQE2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11060">
        <property type="entry name" value="CYP57A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF175">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE PKFB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="474"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK4044295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="533" mass="60131" checksum="8A8C96361528EF64" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PQS5</accession>
    <name>A0AAN6PQS5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_32286</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </evidence>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854324">
        <property type="protein sequence ID" value="KAK4043801.1"/>
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    </dbReference>
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            <end position="32"/>
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        </source>
    </evidence>
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</entry>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854323">
        <property type="protein sequence ID" value="KAK4043831.1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Arrestin_domain-protein"/>
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        <property type="entry name" value="LDB19_N"/>
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        <property type="entry name" value="PROTEIN LDB19"/>
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    </dbReference>
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        </location>
    </feature>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="Pfam" id="PF13002"/>
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    </evidence>
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            <dbReference type="EMBL" id="KAK4043831.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="531" mass="58177" checksum="36A9AC2978148237" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PSD4</accession>
    <name>A0AAN6PSD4_9PEZI</name>
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        <recommendedName>
            <fullName evidence="8">Pre-mRNA-splicing factor RSE1</fullName>
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        <alternativeName>
            <fullName evidence="10">Pre-mRNA-splicing factor rse1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">C8A01DRAFT_31896</name>
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    <organism evidence="14 15">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
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            <taxon>Fungi</taxon>
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    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in pre-mRNA splicing and cell cycle control.</text>
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    <comment type="subunit">
        <text evidence="2">Associated with the spliceosome.</text>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the RSE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854322">
        <property type="protein sequence ID" value="KAK4044026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0AAN6PSD4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001143">
        <property type="entry name" value="Pre-mRNA-splicing factor rse-1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000068">
        <property type="entry name" value="Pre-mRNA-splicing factor rse1, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018846">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058543">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050358">
        <property type="entry name" value="RSE1/DDB1/CFT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004871">
        <property type="entry name" value="RSE1/DDB1/CPSF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10644">
        <property type="entry name" value="DNA REPAIR/RNA PROCESSING CPSF FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10433">
        <property type="entry name" value="Beta-prop_RSE1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23726">
        <property type="entry name" value="Beta-prop_RSE1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03178">
        <property type="entry name" value="CPSF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="RSE1/DDB1/CPSF1 first beta-propeller" evidence="12">
        <location>
            <begin position="20"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 second beta-propeller" evidence="13">
        <location>
            <begin position="464"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 C-terminal" evidence="11">
        <location>
            <begin position="855"/>
            <end position="1177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00055157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00068521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF10433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF23726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK4044026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1211" mass="133836" checksum="98D2D18169716825" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PTJ8</accession>
    <name>A0AAN6PTJ8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_31638</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854320">
        <property type="protein sequence ID" value="KAK4044320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PTJ8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF26">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="228"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="110"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="170"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="294"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="796"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="141"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="37"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="119"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="321"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4044320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="874" mass="96496" checksum="FA439C2CFF3F9E1D" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SLK2</accession>
    <name>A0AAN6SLK2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_51015</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854645">
        <property type="protein sequence ID" value="KAK4032129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SLK2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3370:FF:000001">
        <property type="entry name" value="40S ribosomal protein S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00545">
        <property type="entry name" value="Ribosomal_eS24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053709">
        <property type="entry name" value="eRP_eS24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001976">
        <property type="entry name" value="Ribosomal_eS24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018098">
        <property type="entry name" value="Ribosomal_eS24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10496">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01282">
        <property type="entry name" value="Ribosomal_S24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00529">
        <property type="entry name" value="RIBOSOMAL_S24E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="426"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="430"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4032129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="458" mass="51024" checksum="B1ED7EF2D76951B0" modified="2024-10-02" version="1">MQSWVDSQISRFCWQNLQVDPTPVFPDAELLRDELAQETIYERVFSDDVPLRPPRRYQVRILKELIARIESSVQDWDQHGISDNLTLALSNLLSQPLPSETDAAQQRDYVVYHLSLLQAPSAAPNLPHINLLESRSLISASGTTGLRTWEAALHLGQYLCADPSLVQNKRVLELGTGTGYLAVLCAKYLGSDHVMASDGSDEVVNHMSDSIFLNGLQGSPKVAAMQLKWGHALVGTELEGALERLDTVLGADITYDVSVIPALVATLEDLARLFPGVSVLIAATERNRATFESFLDRENPTETSGYRDRGSIANIDRHPTAKMADSDSPVTLRTRKFIRNPLLGRKQMVVDILHPNRANISKEELRDKLAGMYKAQKDQVSVFGLRTQFGGGKTTGFALVYDSPEAMKKFEPHYRLVRVGLATKIEKASRQQRKQRKNRQKTLRGTAKVKGPKAKKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SLM1</accession>
    <name>A0AAN6SLM1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_20076</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854564">
        <property type="protein sequence ID" value="KAK4032921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SLM1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4032921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="197" mass="21113" checksum="9F15D295287E47B6" modified="2024-10-02" version="1">MSWLRSVGSPLGRGAQCLLQGSPAVPAWRASTAATTPVRRIATNRTTQAPRPISRSFSTHKPANTTGQTSRFRRSEASTAETPVSAAGEDAAPETDSSATAAGQSAPTPRPFASPTPRPQPRPHLGSQAPPEPRKPVDTSSKEYKQAASKYVRFVVALPILLVTSYFLYQRHTVEAQLKLRIITADSPPSQEPSSEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SM55</accession>
    <name>A0AAN6SM55_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RGS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_20695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854635">
        <property type="protein sequence ID" value="KAK4032205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SM55"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845">
        <property type="entry name" value="REGULATOR OF G PROTEIN SIGNALING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845:SF267">
        <property type="entry name" value="REGULATOR OF G PROTEIN SIGNALING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G06860)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RGS" evidence="1">
        <location>
            <begin position="29"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4032205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="196" mass="22223" checksum="E8B79D2B42B54C66" modified="2024-10-02" version="1">MHSPHCQSLPTLSNILSDTAPYPWTLDKFVDHLVANHCLETLEFIHYSSIYRACYEQVTCTTPSRSTSSTPEHEHLRSLWVGLIDTYIAPNGKREVNLPFHVKTRLLATLQSDNTPSPLMLDSAVSLVYDLMEGSMMVSFLNSPSPSKPPEAGGTGRWNHHKFRWTLRWNDIGKLRLRWSLRGLSGLGLGRRKRAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SNK4</accession>
    <name>A0AAN6SNK4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Altered inheritance of mitochondria protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_39686</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AIM6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854507">
        <property type="protein sequence ID" value="KAK4033838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SNK4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08577">
        <property type="entry name" value="PI-PLCc_GDPD_SF_unchar3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039559">
        <property type="entry name" value="AIM6_PI-PLC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051236">
        <property type="entry name" value="HAT_RTT109-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31571">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31571:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4033838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="379" mass="42428" checksum="A344073BED9A9DE2" modified="2024-10-02" version="1">MASWRFDKPKSAMVVEYLPIAEDADDGEDGMNGHGIRTAQHKPRMQWSWPTYLLGLAVVAITFLAVSAGETIAHHYLGARNIRGDPFENWGKPGTGTEELAWYPTDFLRDVLPLPCHSHNDYWRKIPLFTALYAGCTGVEADVWLRNGDLLVGHDTASLQPNRTFQSLYVNPLVEILTHQNPTTDFYAGTKNGAFDTDPNQPLVLLVDIKTDGAQTWPWVMKQLAPLRERGWLSYYEEGEFRQGAITVVGTGNAPFEQIVGGGNASSRRDAFFDAPLDKLEGSGYNSTNSYYASVDFWSAIGLVWWTNGPSESQLGKIRAHIREAKSRGLVSRYWGLPPWPIHVRNRIWEVLVEEGIGMLNVDDLDAATKQDWTKPGTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SNS0</accession>
    <name>A0AAN6SNS0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_48531</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854451">
        <property type="protein sequence ID" value="KAK4035201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SNS0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40788:SF2">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40788">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="575"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="609"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="624"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4035201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="772" mass="87179" checksum="C3B29125DE6B6F76" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SNV1</accession>
    <name>A0AAN6SNV1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_39408</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854494">
        <property type="protein sequence ID" value="KAK4034108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SNV1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF87">
        <property type="entry name" value="COL-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="568"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="40"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="75"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="408"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="677"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="86"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="677"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="696"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="739"/>
            <end position="752"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4034108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="900" mass="97699" checksum="11EF7E6D9D7243E4" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SNV8</accession>
    <name>A0AAN6SNV8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_39514</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854498">
        <property type="protein sequence ID" value="KAK4034035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SNV8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="40"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="122"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="423"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="292"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="43"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="124"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="141"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4034035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="458" mass="51018" checksum="0DA3619059C46FFF" modified="2024-10-02" version="1">MENKDRRKGRRTAGLAAALGVEDAFVRDEGLTWDDYNEFMNDTRGTNADTNSPEHGQGATQTAPPPRPAAFVGEQASDIQHLRPVASSDVEKQTLEGGHGMTYGDAQSRLRRQTGFDNLRMATSAHSNSELPTGTGLSSSRMEDDRRIDPDVPEQLQPSLGDAAPAEVRKKKIVVLKYRPSRWLKLQLERSISARPDGNRHKYKRPHAEITGNDVQHPTRKIRLRPHSADSVHRPHWHWKYLCQAALAVHETRGVPETAPVGQQTTNTEATRDASELQPGVQDQILEGASKMANIEGRISELRRDIDSTEQRGTEMAQDFFDDRQKLDALQAKFDRQEKQIARLKEKMAAEKKENAAKNAELEEKVYNLETALGIASSMANGAQETANTMRTELSALRTEPSPSYNARCKRWRTDSPLRVSGTATRLGVERVGPGKPERAEAEWKGGLGAEPLRSRGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SNY9</accession>
    <name>A0AAN6SNY9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">DUF221-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">C8A01DRAFT_48355</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854444">
        <property type="protein sequence ID" value="KAK4035411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SNY9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022257">
        <property type="entry name" value="PHM7_ext"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF26">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G10920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12621">
        <property type="entry name" value="PHM7_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="399"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="443"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="489"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="537"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="586"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="613"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="654"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="679"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="12">
        <location>
            <begin position="16"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="13">
        <location>
            <begin position="190"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="10">
        <location>
            <begin position="397"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="domain" description="10TM putative phosphate transporter extracellular tail" evidence="11">
        <location>
            <begin position="779"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="726"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="228"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="735"/>
            <end position="747"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK4035411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="879" mass="97585" checksum="8E7C477C5E5F9036" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SP50</accession>
    <name>A0AAN6SP50_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_18668</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854475">
        <property type="protein sequence ID" value="KAK4034542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SP50"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052973">
        <property type="entry name" value="Fungal_sec-metab_reg_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057026">
        <property type="entry name" value="Znf-C2H2_ascomycetes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35392:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35392">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24537">
        <property type="entry name" value="zf-C2H2_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="860"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="60"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="160"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="220"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="684"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="63"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="170"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="220"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4034542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="992" mass="108849" checksum="1987A2FCAB2F575E" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SPB1</accession>
    <name>A0AAN6SPB1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_18670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854475">
        <property type="protein sequence ID" value="KAK4034545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SPB1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4034545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="313" mass="35771" checksum="C51A6F5CA97775A0" modified="2024-10-02" version="1">MGTRHLPSRVSKRSHAVATNDERHQNRRAKVRAARKNNSILRDKLPKAGMIYPFQKTLLRRHRSDVAVATAIKRGTGAPLLTRDLLDDGFHRVFKVATQLLRLQQRDRNNYEFRDNPIALMATVREQPGIREIWGLRTVNMLASVFIVLRAARQNWHKTPRFPFDTAEHSKAAQAIDDFLAVDNLDWGSLAFVEWLLRGGREIMEHAGNHDMMDEGGDWDDETRLFAKQTCPVPMEGIIREEVDGNISFHLSFEAVMEGMRRLNIDVQQDVLIEAFGKLCIEDRALPTPRMDSPRACLEGSEEQVMDIARGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SPC9</accession>
    <name>A0AAN6SPC9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_38363</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854453">
        <property type="protein sequence ID" value="KAK4035159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SPC9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04330">
        <property type="entry name" value="RNAP_III_Rpc25_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.120:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000221">
        <property type="entry name" value="DNA-directed RNA polymerase III subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013238">
        <property type="entry name" value="RNA_pol_III_Rbc25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005576">
        <property type="entry name" value="Rpb7-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08292">
        <property type="entry name" value="RNA_pol_Rbc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03876">
        <property type="entry name" value="SHS2_Rpb7-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88798">
        <property type="entry name" value="N-terminal, heterodimerisation domain of RBP7 (RpoE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase Rpb7-like N-terminal" evidence="8">
        <location>
            <begin position="9"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase III subunit Rpc25" evidence="9">
        <location>
            <begin position="83"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="156"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="161"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU369086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4035159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="199" mass="22501" checksum="AC5755D48C007446" modified="2024-10-02" version="1">MFILTKIADLVQIAPDDFRKQSHVAIEDNINSKYANKVVQKIGLCICLWDILWTSEGLIGQGDGLVNINVEFRVVVFRPFKGEVIAARIADQSAEGINLATDFFDDIFIPWTELPEGSEFEPSETLWVWKEEDQVMYFDDNEMVRFKVLTEEWHDQTPSKPVEAADGAEEAPAPTNTKPPYRITGSMSGPGLGCCLWWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SPW9</accession>
    <name>A0AAN6SPW9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">DASH complex subunit DAD3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Outer kinetochore protein DAD3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">C8A01DRAFT_37331</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DAD3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854421">
        <property type="protein sequence ID" value="KAK4038689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SPW9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013965">
        <property type="entry name" value="DASH_Dad3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28017">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28017:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08656">
        <property type="entry name" value="DASH_Dad3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="15" id="KW-0137">Centromere</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="18" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="22"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00044179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAK4038689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="99" mass="10968" checksum="DC9508F39BA58EFC" modified="2024-10-02" version="1">MDPPPRPQSSLLTSPPELTPLEQEVLEEYERLAENMKKLATHLDNLASAPASDILDGLRELERKTSLVFTLLKASVYSIVLQQEIDWGGGGGGHREQED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SQR0</accession>
    <name>A0AAN6SQR0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_16436</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854396">
        <property type="protein sequence ID" value="KAK4039604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SQR0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="502"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4039604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="600" mass="65537" checksum="22EAD0C3FEB19F7C" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SRJ5</accession>
    <name>A0AAN6SRJ5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Flavin reductase like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_36085</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the flavoredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854388">
        <property type="protein sequence ID" value="KAK4039952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SRJ5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33798:SF5">
        <property type="entry name" value="FLAVIN REDUCTASE LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33798">
        <property type="entry name" value="FLAVOPROTEIN OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin reductase like" evidence="6">
        <location>
            <begin position="90"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="33"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4039952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="299" mass="32879" checksum="A5948EA3E91B5353" modified="2024-10-02" version="1">MAAEKTATWEKQIQRNPHPDFKKVEASRPPFDPSTTLTYTQTPDPNWQFGSGANATTPPADTEKKHIPIDPYAPDRPAGFNYKLLISAIVPRPIAFLSTRSADGATTNLAVFSYFQLIGHDPPLFVVGFASALDAARAKDSLRNLHERRECVINMISEGFVEAANSTSINAPYGVSEWDVSGLTPVYDCETVGCARVKEAVFAIEGKLESVREFESRATPGKVTATLAVIEGTRFWAREDAVNEEKNILDDKVLRPISRLGGITYGRQTEAFELPRPDFEKDLGGIEGAKKLESKHVPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SS42</accession>
    <name>A0AAN6SS42_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="4">2.7.7.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Mitochondrial DNA polymerase catalytic subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">C8A01DRAFT_36033</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Involved in the replication of mitochondrial DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA polymerase type-A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="4"/>
    <dbReference type="EMBL" id="MU854387">
        <property type="protein sequence ID" value="KAK4039983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SS42"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005760">
        <property type="term" value="C:gamma DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006264">
        <property type="term" value="P:mitochondrial DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08641">
        <property type="entry name" value="DNA_pol_gammaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000035">
        <property type="entry name" value="DNA polymerase gamma, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.390:FF:000003">
        <property type="entry name" value="DNA polymerase gamma, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.390:FF:000006">
        <property type="entry name" value="DNA polymerase gamma, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.390">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019760">
        <property type="entry name" value="DNA-dir_DNA_pol_A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002297">
        <property type="entry name" value="DNA-dir_DNA_pol_A_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001098">
        <property type="entry name" value="DNA-dir_DNA_pol_A_palm_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041336">
        <property type="entry name" value="DNApol_Exo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047580">
        <property type="entry name" value="POLG_palm_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10267">
        <property type="entry name" value="DNA POLYMERASE SUBUNIT GAMMA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10267:SF0">
        <property type="entry name" value="DNA POLYMERASE SUBUNIT GAMMA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00476">
        <property type="entry name" value="DNA_pol_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18136">
        <property type="entry name" value="DNApol_Exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00867">
        <property type="entry name" value="DNAPOLG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00482">
        <property type="entry name" value="POLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00447">
        <property type="entry name" value="DNA_POLYMERASE_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family A palm" evidence="16">
        <location>
            <begin position="698"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="479"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1070"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1158"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1078"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="1161"/>
            <end position="1172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00057053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAK4039983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1178" mass="131568" checksum="B9A95E7C00E0A06B" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SSN1</accession>
    <name>A0AAN6SSN1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Calcium channel YVC1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_46093</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854373">
        <property type="protein sequence ID" value="KAK4040626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SSN1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056337">
        <property type="entry name" value="LHD_YVC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052971">
        <property type="entry name" value="TRP_calcium_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056336">
        <property type="entry name" value="YVC1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859">
        <property type="entry name" value="NONSELECTIVE CATION CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859:SF1">
        <property type="entry name" value="NONSELECTIVE CATION CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23190">
        <property type="entry name" value="LHD_TRPY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23317">
        <property type="entry name" value="YVC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="320"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="349"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="420"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="446"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="485"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="545"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="571"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="domain" description="YVC1 N-terminal linker helical" evidence="3">
        <location>
            <begin position="70"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Calcium channel YVC1-like C-terminal transmembrane" evidence="4">
        <location>
            <begin position="314"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="644"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="670"/>
            <end position="680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4040626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="680" mass="76198" checksum="115C81370ACEADFE" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SSU5</accession>
    <name>A0AAN6SSU5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Armadillo-type protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_45742</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. Involved in pre-tRNA splicing, probably by affecting the interaction of pre-tRNA with splicing endonuclease.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the exportin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854365">
        <property type="protein sequence ID" value="KAK4041015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SSU5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042565">
        <property type="term" value="C:RNA nuclear export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045478">
        <property type="entry name" value="Exportin-5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045065">
        <property type="entry name" value="XPO1/5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223">
        <property type="entry name" value="EXPORTIN 1/5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223:SF3">
        <property type="entry name" value="EXPORTIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19273">
        <property type="entry name" value="Exportin-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="5">
        <location>
            <begin position="43"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1210"/>
            <end position="1273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4041015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1273" mass="142411" checksum="2B5C20F02A54AA5B" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SSZ9</accession>
    <name>A0AAN6SSZ9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Dihydrolipoyl dehydrogenase</fullName>
            <ecNumber evidence="2 9">1.8.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">C8A01DRAFT_45727</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + NAD(+) = N(6)-[(R)-lipoyl]-L-lysyl-[protein] + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15045"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="1.8.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="9">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="9">The active site is a redox-active disulfide bond.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.4" evidence="2 9"/>
    <dbReference type="EMBL" id="MU854365">
        <property type="protein sequence ID" value="KAK4041001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SSZ9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045254">
        <property type="term" value="C:pyruvate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004148">
        <property type="term" value="F:dihydrolipoyl dehydrogenase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006103">
        <property type="term" value="P:2-oxoglutarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045333">
        <property type="term" value="P:cellular respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.30:FF:000001">
        <property type="entry name" value="Dihydrolipoyl dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000025">
        <property type="entry name" value="Dihydrolipoyl dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000050">
        <property type="entry name" value="Nuclear protein (Sgd1), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050151">
        <property type="entry name" value="Class-I_Pyr_Nuc-Dis_Oxidored"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003891">
        <property type="entry name" value="Initiation_fac_eIF4g_MI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006258">
        <property type="entry name" value="Lipoamide_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01350">
        <property type="entry name" value="lipoamide_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22912:SF151">
        <property type="entry name" value="DIHYDROLIPOYL DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22912">
        <property type="entry name" value="DISULFIDE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02847">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00544">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51366">
        <property type="entry name" value="MI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 9" id="KW-0274">FAD</keyword>
    <keyword evidence="3 9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 9" id="KW-0520">NAD</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8 9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MI" evidence="11">
        <location>
            <begin position="563"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="22"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="517"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="25"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="163"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK4041001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1225" mass="134575" checksum="1F42025D80FDA59F" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6ST42</accession>
    <name>A0AAN6ST42_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_34868</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854363">
        <property type="protein sequence ID" value="KAK4041136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6ST42"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4041136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="162" mass="18286" checksum="D37D1B4036B82A4E" modified="2024-10-02" version="1">MSALERELAKSKMESQKSLDQDNRDWQRERWQQARRDMAADCFKTLPPARFPVILTPDGPVSLALHLQRLAESESLPETVETSQVDWNEVEVNKVTICHVSLEEKKRMKEKAEVLLGVKENIRVMFNGKTRYAMVVTGLKGGVTLGDTDEDDGSGEPGKLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6ST87</accession>
    <name>A0AAN6ST87_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_44685</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854343">
        <property type="protein sequence ID" value="KAK4042304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6ST87"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF30">
        <property type="entry name" value="MID2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="16"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="242"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="74"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="192"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="242"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="309"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4042304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="402" mass="40583" checksum="A5111697B763217C" modified="2024-10-02" version="1">MSIPYRVFPRLKRQIFSMSNNKSDGAEAPTSTSENPPTASSTEVPPPASSSSTTLPPPPSTTSSTSSPSPPPATTSSSSSAPPSDSSSSQRPPASSSSSQPPPGTSSSPDTPPATSTQYTTVTTPYVPTNQPTGATSSATSTSGSAIDPSSSPSGGLGSSGTIAVAVVVPIAAVAILVLVGIFLWRKRKQRKDAEEQRRKEVEDYGYNPNADPTIPAVAGTAYEMREDGSAGYRGWGSTTLAGSTGRKASTTMSGGAAYSDAASPTRGAVSDARSGEPLMGDSPPSPEGEILGVMGPSAANNRADVRRGPSNASSSYSAAGRSDGSGDGPIGVAYGGNGGGGGNQYYDQYGGGNPYVDNGYGGQPAEAGGQPVIRDVTARRNTRIENSAHYPQQTAGISQNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6STC1</accession>
    <name>A0AAN6STC1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">6-hydroxy-D-nicotine oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_34685</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854360">
        <property type="protein sequence ID" value="KAK4041273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6STC1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050432">
        <property type="entry name" value="FAD-linked_Oxidoreductases_BP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006093">
        <property type="entry name" value="Oxy_OxRdtase_FAD_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878:SF91">
        <property type="entry name" value="FAD BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G12070)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878">
        <property type="entry name" value="GULONOLACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00862">
        <property type="entry name" value="OX2_COVAL_FAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042810390" evidence="3">
        <location>
            <begin position="19"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="4">
        <location>
            <begin position="119"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4041273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="596" mass="65129" checksum="F5BFD899DAAA4B68" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6STL0</accession>
    <name>A0AAN6STL0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_14640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854353">
        <property type="protein sequence ID" value="KAK4041661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6STL0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37451">
        <property type="entry name" value="MARVEL DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37451:SF3">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4041661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="297" mass="32544" checksum="C69E0E4BBF4996B0" modified="2024-10-02" version="1">MWEDLEFDPERIPTFKLVFHSLQILFGFVSWALGIAVFRADGSKVVGNNGWTFAVFFLSVPAWIYLMMAPRFPRTRKIAEPHAMLVVDALFVVIWLSAFSTQAAYNTANLCGTACGISKAVVAMGVFVCLFFGVTTFFSIWTLKYYQWNNRLPGYDRAQLNSQNIDPDKAAFSMAPHDEEAYAPVNVNDHEHDDHLDGSHYGGGAGASVVGGGARSDYSDPYGAGTASHVGGASTVSSYHDNPFRQQEANPFDSHETEYSSASMSAAGGGRYAAPTAMDGFEDARFPHADYDRITRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6STQ3</accession>
    <name>A0AAN6STQ3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">C8A01DRAFT_44739</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat HIR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854344">
        <property type="protein sequence ID" value="KAK4042217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6STQ3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033186">
        <property type="term" value="C:CAF-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000461">
        <property type="entry name" value="Chromatin assembly factor 1 subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055410">
        <property type="entry name" value="Beta-prop_CAF1B_HIR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045145">
        <property type="entry name" value="PTHR15271"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15271">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15271:SF4">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24105">
        <property type="entry name" value="Beta-prop_CAF1B_HIR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CAF1B/HIR1 beta-propeller" evidence="11">
        <location>
            <begin position="1"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="59"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="124"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="159"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="CAF1B/HIR1 beta-propeller" evidence="11">
        <location>
            <begin position="308"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="199"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="414"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="558"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="664"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="428"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="567"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="599"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="624"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF24105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK4042217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="728" mass="77240" checksum="6998D3542040BE84" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6STW5</accession>
    <name>A0AAN6STW5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Large ribosomal subunit protein mL38</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_33038</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the phosphatidylethanolamine-binding protein family. Mitochondrion-specific ribosomal protein mL38 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854334">
        <property type="protein sequence ID" value="KAK4042934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6STW5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00866">
        <property type="entry name" value="PEBP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.280.10:FF:000004">
        <property type="entry name" value="Mitochondrial large ribosomal subunit YmL35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035810">
        <property type="entry name" value="PEBP_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362:SF82">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="46"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4042934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="473" mass="53335" checksum="673CFB5140B082FC" modified="2024-10-02" version="1">MSRPQQVARPIVRSLRQAAGGTATCPSRPIALRTFSSTPSRKDETTTTTTSTPAEPSADAQKLAADAALLGPKKPAPYPSMIKQGTEDQLSQLLSPQLGSRRRRAALATTGDIPFEQLPYQCFQEARKVLGQDREEKVAKIVAETAKIKRLEAADASTFRGGEAYKQKRLESLREHVERLKILADINDPLVKRRFEDGQGDMNKPVYRYLAQRKWYSMQRKIILQRVEQFHIVPDLLPKFEPIMDVKMTFRGYKTPPGAILNSRITETAPTLRMQVFDKGERLFSIVVLDADVPDAETDSFKKRLHFLATNIPWNPAKDSLPLSRLGSEAAAASSPELGALAVPWLPAFAQKGSPYHRLTVFVLQHSNNAPLDSAKLQELYDGQGRDGFSLKSFRDKFALTPVGFTMFRSVWDENTADVMARHGIPGADVEFRHQRVMSLKPPRPARGWEAKRQKPKYRHLWKYTKRIKGMKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6STW8</accession>
    <name>A0AAN6STW8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_34137</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854350">
        <property type="protein sequence ID" value="KAK4041888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6STW8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4041888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="120" mass="13354" checksum="AFA96CE643C0CE4B" modified="2024-10-02" version="1">MLLPPPIPITTTTGLSCYIIAPNASSYTPRNYADSPNICRNCAPTSTCRILFYRRSSSSVACRMTSANPDTFVLLLLPPPPPPSRNTESNIQNPYHSRLTRWNPIRYASVLNNNSSIDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6STZ0</accession>
    <name>A0AAN6STZ0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_13362</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. gTMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854332">
        <property type="protein sequence ID" value="KAK4043024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6STZ0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050447">
        <property type="entry name" value="Erg6_SMT_methyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025774">
        <property type="entry name" value="PiNMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44068:SF11">
        <property type="entry name" value="GERANYL DIPHOSPHATE 2-C-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44068">
        <property type="entry name" value="ZGC:194242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51581">
        <property type="entry name" value="SAM_GTMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="SAM motif I" evidence="4">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="157"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="SAM motif III" evidence="4">
        <location>
            <begin position="251"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="168"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4043024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="374" mass="39609" checksum="BDAFD2E77218DBEE" modified="2024-10-02" version="1">MPAATATTAAGDGETTDLSTQYDTPLGLAHTTMQALKDRIKLHYDLASDYYLNLWGEHIHHGYWPTATSKATDSKETAQLNLIRLLLSISSLSPPQGREELKEQQQLRILDVGCGVGGTTRYLASELGAAVTGITISGKQVQIAGRLSKAAAAAAAATPGVDGTGNGDGEDGAADGDGDGSKAEEGDGFIPLGDRGGKVRFIELDAEKMGEFFSPSGGGGQAGGGFDVVWISEALSHFPNKALFFHNAHKLLRPGGKLVLADWFRAEGLGEGVFEADIKPIEDGMLLPPLCTQQEYVNLATGAGLEVLGGPKDISKDVSKTWDISWSLVQNPSLWAFAFSQGRDGIAFLQAFRAMRRGYANGSFRYAVMAFAKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SU30</accession>
    <name>A0AAN6SU30_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Catabolite repression protein creC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_43925</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. Required to prevent the proteolysis of the CreB deubiquitinating enzyme in the absence of carbon catabolite repression. CreB deubiquitinating enzyme stabilized in a complex with the CreC leads to the expression of genes such as those in the proline and quinate pathways.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Interacts with creB.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat creC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854331">
        <property type="protein sequence ID" value="KAK4043144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SU30"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045013">
        <property type="term" value="P:carbon catabolite repression of transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051362">
        <property type="entry name" value="WD_repeat_creC_regulators"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14107:SF16">
        <property type="entry name" value="AT02583P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14107">
        <property type="entry name" value="WD REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="417"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="107"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="513"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="557"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="70"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="107"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="120"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="536"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4043144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="629" mass="69235" checksum="710B75348CE14B3B" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SU40</accession>
    <name>A0AAN6SU40_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Glutamate decarboxylase</fullName>
            <ecNumber evidence="3 9">4.1.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">C8A01DRAFT_44784</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 9">
            <text>L-glutamate + H(+) = 4-aminobutanoate + CO2</text>
            <dbReference type="Rhea" id="RHEA:17785"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:59888"/>
            <dbReference type="EC" id="4.1.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the group II decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.15" evidence="3 9"/>
    <dbReference type="EMBL" id="MU854345">
        <property type="protein sequence ID" value="KAK4042128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SU40"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004351">
        <property type="term" value="F:glutamate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006538">
        <property type="term" value="P:L-glutamate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000017">
        <property type="entry name" value="Glutamate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.50:FF:000001">
        <property type="entry name" value="Glutamate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010107">
        <property type="entry name" value="Glutamate_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01788">
        <property type="entry name" value="Glu-decarb-GAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43321">
        <property type="entry name" value="GLUTAMATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43321:SF3">
        <property type="entry name" value="GLUTAMATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="18"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK4042128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="575" mass="63977" checksum="98CB729ECCF8BB76" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SU55</accession>
    <name>A0AAN6SU55_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Ubiquitin-like protein ATG12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_14024</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Ubiquitin-like protein involved in cytoplasm to vacuole transport (Cvt), autophagy vesicles formation, mitophagy, and nucleophagy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Forms a conjugate with ATG5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Preautophagosomal structure membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ATG12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854342">
        <property type="protein sequence ID" value="KAK4042380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SU55"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034274">
        <property type="term" value="C:Atg12-Atg5-Atg16 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000421">
        <property type="term" value="C:autophagosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019776">
        <property type="term" value="F:Atg8-family ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097352">
        <property type="term" value="P:autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061723">
        <property type="term" value="P:glycophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01612">
        <property type="entry name" value="Ubl_ATG12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007242">
        <property type="entry name" value="Atg12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13385">
        <property type="entry name" value="AUTOPHAGY PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13385:SF0">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN ATG12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04110">
        <property type="entry name" value="APG12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0072">Autophagy</keyword>
    <keyword evidence="3 6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="4 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4042380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="147" mass="15707" checksum="90A3D9C4106E737E" modified="2024-10-02" version="1">MASDNNNNNTTTSTPASPVLSGRSSPDLPLTMTASTVLMTLPRDATAALAAAGAFPHEKIVVRFKPVGGSAPPLRRELVKVASAHKFESVVAYLRKTLRVGEAESVFLYVNSTFAPALDEVVGNLWRCFKDSNEHLNVSYSVTPAFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SVI5</accession>
    <name>A0AAN6SVI5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_43070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854321">
        <property type="protein sequence ID" value="KAK4044152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SVI5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF7">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="80"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4044152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="329" mass="36798" checksum="69B60CE43A6926F4" modified="2024-10-02" version="1">MFKRSFRSRDASTSQREAASTAMDSQHRVDKSARLTRKGATRDHQKVSKLQRSLKGEDASRMPSEQARPSDKSLAPSPIITLVVGQEARLFAAHEDVLRQAPFFDKVLRSSYVDAQNRRISLPDEEPEVFSAILEYLYKGDYYPRLLQNKQRSSWELEDSLPRRATPQASPAIHESPKIGGGRAGQTPQTPSAVEATVYLASVGQHLLRDTVIYCAAERYGLDELKRLALRKQGLQSGIDVATILRSAQYCYAHTPDSDSRLRAHYLALIIRCRKTFKRSGTMQAEMEKCGSGVYGEGSGKLFFDLFVAMCNHLDDVIEASNARTPKTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SVI8</accession>
    <name>A0AAN6SVI8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tr-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_32214</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854325">
        <property type="protein sequence ID" value="KAK4043686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SVI8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050055">
        <property type="entry name" value="EF-Tu_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721">
        <property type="entry name" value="ELONGATION FACTOR TU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721:SF30">
        <property type="entry name" value="TR-TYPE G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="2">
        <location>
            <begin position="300"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="631"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="638"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4043686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="901" mass="94803" checksum="3031367BFEFCDBC4" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SVM7</accession>
    <name>A0AAN6SVM7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_32024</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="MU854323">
        <property type="protein sequence ID" value="KAK4043925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SVM7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042661787" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="19"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="30"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4043925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="542" mass="59105" checksum="0B2378F17F7ABB7E" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SVX5</accession>
    <name>A0AAN6SVX5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Anticodon-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_31920</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854322">
        <property type="protein sequence ID" value="KAK4044048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SVX5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004820">
        <property type="term" value="F:glycine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070150">
        <property type="term" value="P:mitochondrial glycyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00774">
        <property type="entry name" value="GlyRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00858">
        <property type="entry name" value="GlyRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.720.200:FF:000001">
        <property type="entry name" value="Glycine--tRNA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000004">
        <property type="entry name" value="Glycine--tRNA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027031">
        <property type="entry name" value="Gly-tRNA_synthase/POLG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033731">
        <property type="entry name" value="GlyRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002315">
        <property type="entry name" value="tRNA-synt_gly"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00389">
        <property type="entry name" value="glyS_dimeric"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003211">
        <property type="entry name" value="PRK04173.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745:SF0">
        <property type="entry name" value="GLYCINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745">
        <property type="entry name" value="GLYCYL-TRNA SYNTHETASE/DNA POLYMERASE SUBUNIT GAMMA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01043">
        <property type="entry name" value="TRNASYNTHGLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Anticodon-binding" evidence="9">
        <location>
            <begin position="522"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4044048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="640" mass="70893" checksum="54EF9852CC694F1E" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SWC6</accession>
    <name>A0AAN6SWC6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_31312</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854318">
        <property type="protein sequence ID" value="KAK4044526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SWC6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4044526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="279" mass="30510" checksum="6C0C168F3EB48ECB" modified="2024-10-02" version="1">MITNNPDIAVANKHDAAGNRSAPPLPSFEERNSPADPVNLTPETRRIRWTLNGPLETAITVSRHDAHHFDPDEVPEPYHYHRAGPSGNDDANWHPFSQLPLTEPQKHDQHTDPDEKRESDIPDDQVLYGPLPPGAGADGDEELDSDGDEHLLVCCGQKRPLGKGVSGAGAVVVKPTTTGSFVTIHDFISTVHPYLMARRDEVLEAMGEDPGRTGAPFPPETTRLVVIWYSAPYVDVLDEASWMRTRKRRRSGSGKKEVDAQGDGPVGLANGIGERWDSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P433</accession>
    <name>A0AAN6P433_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nucleoside phosphorylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_51530</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854842">
        <property type="protein sequence ID" value="KAK4031366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P433"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="3">
        <location>
            <begin position="47"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="4">
        <location>
            <begin position="389"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4031366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="870" mass="97636" checksum="7B5AED5D1855A007" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P4G9</accession>
    <name>A0AAN6P4G9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_51381</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854752">
        <property type="protein sequence ID" value="KAK4031593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P4G9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF13">
        <property type="entry name" value="MFS GENERAL SUBSTRATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="342"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="426"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="451"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="493"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="517"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="553"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4031593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="574" mass="62157" checksum="5A07415301087AFA" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P4V2</accession>
    <name>A0AAN6P4V2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_41774</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854702">
        <property type="protein sequence ID" value="KAK4031788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P4V2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4031788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="208" mass="23118" checksum="5ADA9D6E955AA299" modified="2024-10-02" version="1">MTEGAHPDSSLETLRAENYDLRLENDRLTWDNTMLRKEVEELRAASLPRRSSHSTAADKSYMKPTTASRFRQAAVSRELNTHTEAWEPSTWNVSPPTKRHDGHTPGYMQPTAASHQKRGSQRAAVAQAQPKVRLQRPTKIRKSSRLDDSLWQTLRGRTEQPVAKIISRPPVAEQQPLTTGSESSPASPPVLADSTMTGTSPASSVLVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P4W4</accession>
    <name>A0AAN6P4W4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HAD-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_41736</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854696">
        <property type="protein sequence ID" value="KAK4031819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P4W4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046474">
        <property type="term" value="P:glycerophospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000069">
        <property type="entry name" value="HAD-superfamily subfamily IIA hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050324">
        <property type="entry name" value="CDP-alcohol_PTase-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006353">
        <property type="entry name" value="HAD-SF_hydro_IIA_CECR5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01456">
        <property type="entry name" value="CECR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269:SF51">
        <property type="entry name" value="HYPOTHETICAL HAD-SUPERFAMILY HYDROLASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13242">
        <property type="entry name" value="Hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4031819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="536" mass="59607" checksum="678E4EAF791F28A6" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P5V7</accession>
    <name>A0AAN6P5V7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_42180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854846">
        <property type="protein sequence ID" value="KAK4031357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P5V7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4031357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="282" mass="32096" checksum="4757C297E488E999" modified="2024-10-02" version="1">MEYWAQNLDWSRLRRLRLYDSSVPLAADLAPQLTALDEIELSSDYDGDNMNIPAFFNNLPSTLASVSLPSVPTSGLSTLTAHAARLHTLSIHTSPLTNQDLSLLRDALPLLKTLTVVCTRDAGTWPHDTLSILASFPRLQSLTIWFPIGPADAPHEPYLTLSSASRLFTELRERGASKLWRLRVHSGFKPRPFLGFPADSAYWWGHNVTSFVCQGHGDDGHAPRVTRCLKLSREQNERLRRVSRGERMKKEEENHIEFLVALRGPMTMDNYLNWRKERGRYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P635</accession>
    <name>A0AAN6P635_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Mitochondrial carrier domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">C8A01DRAFT_41266</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854625">
        <property type="protein sequence ID" value="KAK4032305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P635"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF26">
        <property type="entry name" value="CARRIER PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G07710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="200"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK4032305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="494" mass="53605" checksum="C2821A06449FF6E1" modified="2024-10-02" version="1">MPSPSNRSRGDDPTSPPTSPSASASPPALAPLTLPFDTGILPVIPDGSPLPEKPPASNAATGASAAGVRALTTQAVAFYFRAPAKAFFRTRVDYLAYARALQEQQQQAATLLLSSSSSPPSPVPKQPWTTWLLTRLRATTPAVLASAVRHSGWRVVPDQILPPLVANVGVGAVLYTSYLQILGRLHPESARASKRVYPPPGPVETFTAGFLAGAVQSLVAAPLDAVQARWDGVTSGRVGNGNGNGNGNGNGGQTPQRSMWAFSAAKLREIGVRGVFSGWGLSFLKDSLGSAVFFSVFEYVKAQGYYNFVRWYYGSLSGDAIVLLSRKRPAPGDGRGIASEEQKMPTIIRPHYAIEPAFLLLAGMGASVTQQVVLHPLSHVQAEHWERLEGLDAKARKLRREARLPEASNSASRWHMLRAYRDAYRTTWAECMAEAQAAGLTMRQWLYRGFWWNTVRQVPSTSAGLIIFELVRRKYGFGGDQVRINRDGYDILLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P692</accession>
    <name>A0AAN6P692_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_51397</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854760">
        <property type="protein sequence ID" value="KAK4031567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P692"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37844">
        <property type="entry name" value="SER/THR PROTEIN PHOSPHATASE SUPERFAMILY (AFU_ORTHOLOGUE AFUA_1G14840)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37844:SF2">
        <property type="entry name" value="SER_THR PROTEIN PHOSPHATASE SUPERFAMILY (AFU_ORTHOLOGUE AFUA_1G14840)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4031567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="252" mass="28495" checksum="D3604777A36211F8" modified="2024-10-02" version="1">MSPTVFQIVSNLHLETQGSYEYNFKQTAPNLALLGDIGQVAHDALFAFLEKQLTRYWNFAKRIERLQARSTIGRFIFLDQTRYDINTILTVLGCTLFSRVTQDQAAAVAGRLIDFRQILNWTVEDHVDAHLSDLRWLNTQVAQISQTQPQRQIVIFTHHSPTTDERATDIRHKGSPVASGFATNLGLEECWTNPSVVMWAFGHTHFSCNFVDERGKRVVANQRGYAMAPQSAFDSEKTFVVGKETGSSMLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P6V8</accession>
    <name>A0AAN6P6V8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_40704</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854570">
        <property type="protein sequence ID" value="KAK4032854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P6V8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4032854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="140" mass="15456" checksum="9FA15436E0E20CCE" modified="2024-10-02" version="1">MAQHETTTKNSTRLPTLIYDGVACSRQDAATTRIEHIMRMFKKSGLGFTGSGADLIPVVQTEPNKYMWRLPARQATREEICTVHHPAHFVWVKALSNKTTQELGELSERMDQGRDSIYVGGTTYGASLISAGAIETCVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P6X4</accession>
    <name>A0AAN6P6X4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_20961</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MAD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854683">
        <property type="protein sequence ID" value="KAK4031895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P6X4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016035">
        <property type="term" value="C:zeta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003511">
        <property type="entry name" value="HORMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045091">
        <property type="entry name" value="Mad2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842:SF10">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56019">
        <property type="entry name" value="The spindle assembly checkpoint protein mad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50815">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HORMA" evidence="3">
        <location>
            <begin position="21"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="103"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="265"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="114"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="184"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4031895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="343" mass="36720" checksum="66D026E3E00507E4" modified="2024-10-02" version="1">MPPPLPDPTPDEDSLPLDHSHILLTSFNAFLTVAIHNILYYRAIYPPSTFLSTKAYNLPVHQNRHPKVCAWIRDAVDAVAAQLTTGHVSRVAIVIHSPLEGGAALNNPSPQSPSPSDAFSSTPTSPSQPPTAPLPGGTVLERWLIDTSRFPTWPSPKSKSLTGPPTAAETAKAMHDFTRVLARDARSEDARERHLAPPDPHPLNPSSSFAWADLDEQLRGALRRMASVAEGMGPLLPPLAGEGADGGGCTFTVAVELGEEGRAPIGHPQAWIPSEPNLQPKGKGREVAGEDIGGVRTRPIRAVEAGPLFFECWVEESKAKEVLRRMAEGGEGPTQSQGSTQPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P762</accession>
    <name>A0AAN6P762_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sequence orphan</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_20112</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854567">
        <property type="protein sequence ID" value="KAK4032890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P762"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038781">
        <property type="entry name" value="C365.16-ike"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37845">
        <property type="entry name" value="SEQUENCE ORPHAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37845:SF1">
        <property type="entry name" value="SEQUENCE ORPHAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4032890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="321" mass="34177" checksum="8ADC77DA4F87C5D5" modified="2024-10-02" version="1">MKDSGIGGLEAPRAPPQLQLNAVKPSQLATAASAAPRALPAPAITTEPKTGSTPAAKWNTKNLALRLGTDFISAASAAALVAPIISIIDRSIMENASGQRSLVDSLKSSFQTLLRAPHRVIFSKPFALIFAVYGGTYLTANTLDTATSTTRSLPATHVTSGTAKFAASSAANIGICIYKDQVFVRLFGPQGITPRPVTLPSYLLFAARDCMTIFASFNVPPLLGPALSRRVGDEVQRYVSGQTMAQFAAPAAVQLASTPVHLWGLDIYNRPGVTCWRDRWAVVRKNWAVSTAARICRIVPAFGVGGVVNYKVRRGLMEKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P781</accession>
    <name>A0AAN6P781_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Fungal-specific transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_50405</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854564">
        <property type="protein sequence ID" value="KAK4032920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF81">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="44"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="109"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="735"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="779"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="854"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="901"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1021"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1345"/>
            <end position="1370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="121"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="150"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="743"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="875"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="910"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="934"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1021"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1349"/>
            <end position="1359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4032920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1411" mass="154083" checksum="74B86A279B577940" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P7S8</accession>
    <name>A0AAN6P7S8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Leucine-rich repeat-containing protein 40</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_40237</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854539">
        <property type="protein sequence ID" value="KAK4033294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P7S8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF27">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="870"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="101"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="124"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="178"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="194"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="229"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="289"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="377"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="410"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="893"/>
            <end position="910"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4033294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1149" mass="122351" checksum="8E12C495667E7FD3" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P806</accession>
    <name>A0AAN6P806_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_41107</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854609">
        <property type="protein sequence ID" value="KAK4032450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4032450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="270" mass="30288" checksum="12D8A3AD36AAAEBB" modified="2024-10-02" version="1">MLSKSLIREGSLATEELDIWPPLPHQLKTFQHLLVKMRLLASIPALLALSGAVAAAPVAPESEQWPPAMTADQPGEAELKTIWAQGLNVTAQAEPIPASAILAPGAAAEDDVFAAQSPARRADNNPLLAKRVYDRGMCFEWESWVSANSRQGYYNDFQYAKAIFGGYDQFGWNYIGPMQQFNWGWGSFKLTIRNQDQCERGYFTWDDVLDMMDDLWYHYCQNRGQGWGYVHWNPTLVAMIYYDGSSMPGFQPGCNHTGLKKLRAVEEAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P8V1</accession>
    <name>A0AAN6P8V1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Metalloendopeptidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_41651</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854679">
        <property type="protein sequence ID" value="KAK4031911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P8V1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042910071" description="Metalloendopeptidase" evidence="2">
        <location>
            <begin position="29"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4031911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="463" mass="50458" checksum="C56821784ACA8DB2" modified="2024-10-02" version="1">MLPPSGTGYLGASAALAAVLCLAGLAQGCPPPGSQFAFPDGFWRNDTSSESTLARRWTAIEFGDGTEKLNNDGLNHFGKQWPGGTIPLCFDSTFTQDEEDQIVEGFLKGITMWYISGLSPSSWKIDVSLTRTECQNQGVTGPKENYLWVQRSDLKGMASSTGNSVTGSVFDAQPDSYWKTLKGVPDPLQQKTRQYAHEIGHVFGLLHEHQNPTAWSKERGGTGAADKFELDCTALADYDQCLRYVKDLFDYDAAKVADYMTEMCATNLGPWKYPCKDTQGNNIRLSAWNWLPEVGSQQFVRTGGQLDLKSVMIYDSFSGNKAPGVPVFYLLDGSGGKKTLKPDDGYELYPPSPLDAEGAVLLSPNPREATDNPPYFTAASSQNPTWEAAGNGFSSCSTDPFDDCNAPSPASTASDPFDDCKAMSPSRKRSVTGHNRRHENLMRRGAEARAAMKGRLLATGSYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PAD0</accession>
    <name>A0AAN6PAD0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pyruvate/Phosphoenolpyruvate kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_48980</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854469">
        <property type="protein sequence ID" value="KAK4034684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PAD0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050251">
        <property type="entry name" value="HpcH-HpaI_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30502">
        <property type="entry name" value="2-KETO-3-DEOXY-L-RHAMNONATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30502:SF8">
        <property type="entry name" value="SYNTHASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HpcH/HpaI aldolase/citrate lyase" evidence="4">
        <location>
            <begin position="58"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="296"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4034684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="317" mass="34566" checksum="BB20EED2BF05D9E8" modified="2024-10-02" version="1">MTDKPFPQQPQLHTTAEHRAAVLTYPANLRAALRQAKEDPKKTLLGVAQGIPSVFVTKVMASAKPDFIWMDVEHGIFDRSTLYDCIHAAQHHSEGKTMVVVRIPRHDEVSLTTALDAGAAGIVIPHTDSAQDVRDKVKEIFYPPIGQRSFSPWTFTPGISNQSLYANDEWNMKNSNNHVCLIAQIESVEGMNNIEEIAAMPEVDALMFGPGDYSADAGIDFKLSAPPPQAFIDAMTKFVTTAHKYGKPLFGAAQGAAMIPMMLDQGYKALAVTFDVWGVANMVNDGMKEARAVVEQNADATKQKNEAAKEGNGVPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PAE2</accession>
    <name>A0AAN6PAE2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_39813</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854513">
        <property type="protein sequence ID" value="KAK4033727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PAE2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13577">
        <property type="entry name" value="SnoaL_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042925353" description="SnoaL-like domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="SnoaL-like" evidence="2">
        <location>
            <begin position="26"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4033727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="181" mass="20137" checksum="C3D72DC6BB9C2666" modified="2024-10-02" version="1">MKLFHIFALAPLFLTGTSGTTHSPSALTDREAIIDTLLAFTQSLDDKNETLLRTVTTTNIIFDGTLFADIGLGGREPVVGQDALVPSLLGVLTMPTSHHLSNFRVQLLDAAHADHANLTAYVLAHHHKLLEEPRENLRNLYVMANRYQASMVRDKGKWKLEWLKLLPVWQSGNRAVMGWGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PAP5</accession>
    <name>A0AAN6PAP5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Delta(14)-sterol reductase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">C-14 sterol reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Sterol C14-reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_48859</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ERG4/ERG24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854463">
        <property type="protein sequence ID" value="KAK4034864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PAP5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050613">
        <property type="term" value="F:Delta14-sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001171">
        <property type="entry name" value="ERG24_DHCR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257:SF52">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE TM7SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01222">
        <property type="entry name" value="ERG4_ERG24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="6" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="6" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU369120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4034864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="389" mass="43650" checksum="1E5904ABC486F644" modified="2024-10-02" version="1">MAVGNVEYDFGGPGCPAPALLSPRSLTWASLKRQIPWPEDGIRGFASCLALFRLLPAKEVLGTKLRESGKPLRYRFNAFSSSVVQLVPCAFSTYLYGSNFFLWTWILASGGHTGSVIYDVKTWLAMRPGLTGWHRAYGFLSDSMVFLVAVQAYYVLEGQYAEQGIVGMMDFKTDGLGFMLTFGDIVWVPFLYSTQCRYLAMYPVHMGPFGLAAMGIVFTVGLYILRTSNAREILFREDPDHPAFNNMPYLQTRRGTRLLTGGWWGRARHVNYLGDWLQSLPFCLPTGITGYVILPAGAATGAGAAMMLDGRQVVPGGAAGWGILVTHFYSAWFGLLLVNRERRDDRACVEKYGEDWLEYKRTVRWRILPGITRWNKLDRASASCRRPYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PB42</accession>
    <name>A0AAN6PB42_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein S19-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_48592</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854453">
        <property type="protein sequence ID" value="KAK4035154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PB42"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.860.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.860.10">
        <property type="entry name" value="30s Ribosomal Protein S19, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00531">
        <property type="entry name" value="Ribosomal_uS19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002222">
        <property type="entry name" value="Ribosomal_uS19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020934">
        <property type="entry name" value="Ribosomal_uS19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005713">
        <property type="entry name" value="Ribosomal_uS19_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023575">
        <property type="entry name" value="Ribosomal_uS19_SF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003121">
        <property type="entry name" value="PRK04038.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01025">
        <property type="entry name" value="uS19_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880">
        <property type="entry name" value="RIBOSOMAL PROTEIN S19P FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00203">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002144">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00975">
        <property type="entry name" value="RIBOSOMALS19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54570">
        <property type="entry name" value="Ribosomal protein S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00323">
        <property type="entry name" value="RIBOSOMAL_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4035154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="153" mass="17453" checksum="245192E620C050D1" modified="2024-10-02" version="1">MADTEYNAEEAAELKKKRAFRKFSYRGIDLEALLDLGSDELRDVVHARARRKINRGLKRRPMGLIKKLRKAKQEAKPNEKPDLVKTHLRDMIVVPEMIGSVIGIYSGKEFNQVEIKPEMVGHYLGEFSISYKPVKHGRPGIGATHSSRFIPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PB56</accession>
    <name>A0AAN6PB56_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_38418</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854454">
        <property type="protein sequence ID" value="KAK4035146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PB56"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042941301" description="Secreted protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4035146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="117" mass="13275" checksum="6CA9CECD2528C883" modified="2024-10-02" version="1">MRFEFVTALLAALATTSMADRMTVNTQCPCEWCGSCDSRDATFFTEHGSYGVNANTGCRGTKVPGMTELCVDWERGRAHFYYRGQNKRCLLQKSKTVSSCIADHCHRTEWEEARCSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PBA8</accession>
    <name>A0AAN6PBA8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Neurochondrin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_19834</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854546">
        <property type="protein sequence ID" value="KAK4033201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PBA8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008709">
        <property type="entry name" value="Neurochondrin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13109">
        <property type="entry name" value="NEUROCHONDRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13109:SF7">
        <property type="entry name" value="NEUROCHONDRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05536">
        <property type="entry name" value="Neurochondrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4033201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="646" mass="69637" checksum="AFAD053D5F0D9C53" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PBK0</accession>
    <name>A0AAN6PBK0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_17911</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854445">
        <property type="protein sequence ID" value="KAK4035409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PBK0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4035409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="104" mass="11351" checksum="66145E8C620322C9" modified="2024-10-02" version="1">MGSRYTGAFPCPLRRLVRCCFFPFCFPGEGEQSNHGQGRASQYEAYLYPGAQEGRTDGWGELGERWTLLIVMTVLGLCWMRQNGTCAGDEGIAAAEGKIHGKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PBM9</accession>
    <name>A0AAN6PBM9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">chitin synthase</fullName>
            <ecNumber evidence="3">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">C8A01DRAFT_48418</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:16638"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="3"/>
    <dbReference type="EMBL" id="MU854446">
        <property type="protein sequence ID" value="KAK4035373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035145">
        <property type="term" value="C:exon-exon junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
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        <property type="entry name" value="Nonsense-mediated mRNA decay factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000037">
        <property type="entry name" value="Nonsense-mediated mRNA decay factor (Upf2)"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="4.10.80.160:FF:000001">
        <property type="entry name" value="Nonsense-mediated mRNA decay factor (Upf2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000077">
        <property type="entry name" value="Probable chitin synthase D"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.80.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039762">
        <property type="entry name" value="Nmd2/UPF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007193">
        <property type="entry name" value="Upf2/Nmd2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12839">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY PROTEIN 2 UP-FRAMESHIFT SUPPRESSOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12839:SF7">
        <property type="entry name" value="REGULATOR OF NONSENSE TRANSCRIPTS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04050">
        <property type="entry name" value="Upf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1200"/>
            <end position="1229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1241"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1284"/>
            <end position="1309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1663"/>
            <end position="1682"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1689"/>
            <end position="1707"/>
        </location>
    </feature>
    <feature type="domain" description="MIF4G" evidence="13">
        <location>
            <begin position="465"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="domain" description="MIF4G" evidence="13">
        <location>
            <begin position="670"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="170"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="241"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="424"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="901"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="970"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1017"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1825"/>
            <end position="1851"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1929"/>
            <end position="1950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="241"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="424"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="919"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="979"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="1049"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1833"/>
            <end position="1846"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK4035373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1950" mass="219695" checksum="9F80A19208783996" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PBU5</accession>
    <name>A0AAN6PBU5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GTP-binding protein RHO3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">C8A01DRAFT_19557</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854526">
        <property type="protein sequence ID" value="KAK4033501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PBU5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017157">
        <property type="term" value="P:regulation of exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000780">
        <property type="entry name" value="Rho GTPase Rho3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00067968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK4033501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="205" mass="22993" checksum="1E32E8405ED26187" modified="2024-10-02" version="1">MPCGIGGSKTVQRKLVLLGDGACGKTSLLNVFTRGYFPTVYEPTVFENYVHDIFVDNVHIELSLWDTAGQEEFDRLRSLSYDDTDLIMLCYSVDSKDSLENVESKWVGEIADNCPGVKLVLVALKCDLREAADEEDGANEEANPREKKPMINYDQGLEVARRIHALRYLECSAMRNRGVNEAFTEAARVALSVKKERDDSKCTVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PC76</accession>
    <name>A0AAN6PC76_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_17627</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854434">
        <property type="protein sequence ID" value="KAK4038282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PC76"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF92">
        <property type="entry name" value="AGL026WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="236"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="312"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="410"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="443"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="476"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="62"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4038282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="530" mass="58380" checksum="76B747C1730BF718" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PC87</accession>
    <name>A0AAN6PC87_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription initiation factor TFIID subunit 13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_19033</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TAF13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854494">
        <property type="protein sequence ID" value="KAK4034118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PC87"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003195">
        <property type="entry name" value="TFIID_TAF13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380:SF5">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID/SUPT3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02269">
        <property type="entry name" value="TFIID-18kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="111"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="144"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4034118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="168" mass="19108" checksum="F9676B39A927A4F5" modified="2024-10-02" version="1">MEPRARAGKNVGKMNFGHNELAQLLYGHGDVRAPLNDTVRVLDEILTEFIQGVSFEATRAAQHAGRQKVKFEDFEFAMRRNPDYMGKIQEMFEKKKEIEAARKGFNIEDQLMKDADKEEKAAEKDRDKGVSKRGRKAMARMQIGEEDLEDGDDDLEMELLDGGSAGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PCX3</accession>
    <name>A0AAN6PCX3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">C8A01DRAFT_37416</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854423">
        <property type="protein sequence ID" value="KAK4038649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056501">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF13">
        <property type="entry name" value="POLYKETIDE SYNTHASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23297">
        <property type="entry name" value="ACP_SdgA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23114">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="9">
        <location>
            <begin position="6"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="10">
        <location>
            <begin position="921"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="2119"/>
            <end position="2196"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="6">
        <location>
            <begin position="921"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1076"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="6">
        <location>
            <begin position="1113"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1076"/>
            <end position="1092"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK4038649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="2199" mass="238319" checksum="507822BCAEB9623F" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PD21</accession>
    <name>A0AAN6PD21_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Fungistatic metabolite</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_48518</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854450">
        <property type="protein sequence ID" value="KAK4035255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PD21"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051836">
        <property type="entry name" value="Kremen_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24269">
        <property type="entry name" value="KREMEN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24269:SF16">
        <property type="entry name" value="PROTEIN SLG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042817225" evidence="7">
        <location>
            <begin position="26"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="8">
        <location>
            <begin position="34"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="8">
        <location>
            <begin position="135"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="8">
        <location>
            <begin position="232"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="8">
        <location>
            <begin position="337"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4035255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="443" mass="46564" checksum="EC8B95304B112608" modified="2024-10-02" version="1">MASTGSMTGLRAAVSLIALAATAQALPHKRDGASYTRQGCFVDNLNGHRLLDSAGYADDAMTVETCAAFCSKYQYFGLEYGRECYCANSLSTLAVDDSDCSFSCSGNSAEKCGAQDRLDVYTNTLYVARKPATLEAPYLGCFVDQGARALPDNLLGADDMTAQTCAAHCANYSYFGVEYGRECWCGNSPPKTPAAESDCSTGCAGDDTQLCGADNRINVWGSPLPSPATVGDYEYVGCFTDSGDQRSLRGSVTYDPAMTLEKCAAACAAYAYFGVEFGSQCYCGTDLEASAAQVSQAECSMRCGGAYDSVCGAADRLNVFASTDCKEDPANVPSVAGFSYKSCWADNVAGRVLTGKEVRADDMTVEKCAAFCQGFTHFGVEYGRECYCGNDLAGAAASESECSVVCMGDATQWCGAPDRLNIYEAAAPTTTAAPTVTEPALKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PDY2</accession>
    <name>A0AAN6PDY2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Arginase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_48217</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the arginase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854438">
        <property type="protein sequence ID" value="KAK4038160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PDY2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004053">
        <property type="term" value="F:arginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09999">
        <property type="entry name" value="Arginase-like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.10">
        <property type="entry name" value="Ureohydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43782">
        <property type="entry name" value="ARGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43782:SF3">
        <property type="entry name" value="ARGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4038160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="349" mass="37539" checksum="E1FF51D130F9F473" modified="2024-10-02" version="1">MDAVIRSPLQVEWADGARLETARTRHPPPCPPQILTSITVISAPYHVGLRDSPIHRSRVSEGPDYLKSAGLLSLLRAQNLPIHELEIPPVADAFEGEIGRTFELIRRVSLAVTAARNRASFPIVLAGNCCISVGVAAGLWGSDELRGAEDDALGCVWFDAHDDYNVPDSMVSGYFDSQGIAMMAGECWRALVSSVPGFRPWLLRRVVHCGMRDVNELERGRVEASDMGVVSGDATKKVDFAAGVRKELEERFVEGNDAAVLVHLDVDVMDATLGKANPFACSGGLFEEDITGCMAAILDKTAPMAFTIASFDPLCDGDESAQRLAGLSIKAVEGVLNGLKGRGLLQPRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PE43</accession>
    <name>A0AAN6PE43_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C6 finger domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_16759</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854406">
        <property type="protein sequence ID" value="KAK4039243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PE43"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052973">
        <property type="entry name" value="Fungal_sec-metab_reg_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35392:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35392">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="73"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="318"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="361"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="78"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="362"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="405"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4039243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="831" mass="92912" checksum="1F6AA81CB8E9B5FB" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PE67</accession>
    <name>A0AAN6PE67_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phytanoyl-CoA dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_18180</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PhyH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854455">
        <property type="protein sequence ID" value="KAK4035093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PE67"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883:SF19">
        <property type="entry name" value="MULTIFUNCTIONAL DIOXYGENASE AUSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4035093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="284" mass="31847" checksum="393CFBF8ED2443AB" modified="2024-10-02" version="1">MSTTPKLQQVKPSEGRDAVFRALREDGAVIIKGLFTKDQVRRLNQEVQPAMDNIGVGSKQSEEWLKDFHGDKTKRLNGVVALSETFRHEILENDLIHQLCEEIYLKDAGGYWMNSAQVIDIGPGSKAQPLHRDQWQFPIFTYCGPDAPEASVNFVVALTEFTDENGATRVIPGSHRWDDFQQNGTPEDTIPAEMEVGDACFITGKVVHGGGANRTKDSTRRGITLVFQCSYLTPEEAYPFIVSKEIAKTLSPRGQRMIGFRSQFLKDSPGVWKRDYGEVDEAYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PEL9</accession>
    <name>A0AAN6PEL9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">3beta-hydroxysteroid-dehydrogenase/decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_18671</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854475">
        <property type="protein sequence ID" value="KAK4034562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PEL9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000252">
        <property type="term" value="F:3-beta-hydroxysteroid dehydrogenase [NAD(P)+]/C4-decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002225">
        <property type="entry name" value="3Beta_OHSteriod_DH/Estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF447">
        <property type="entry name" value="HYDROXYSTEROID DEHYDROGENASE_ISOMERASE FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G06450)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01073">
        <property type="entry name" value="3Beta_HSD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="3-beta hydroxysteroid dehydrogenase/isomerase" evidence="4">
        <location>
            <begin position="82"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="3-beta hydroxysteroid dehydrogenase/isomerase" evidence="4">
        <location>
            <begin position="246"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4034562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="502" mass="54853" checksum="F9C3CDD82A874AA8" modified="2024-10-02" version="1">MQDHLIARPDLTAAIAAALLLVVYLVRLNQLLLRTPDEVKKLAPARWTKDVLRDAYQRLETHPVTTRSYAKRIPPGLERRYIVTGGSGLVGGYIVLQLLERGQPPSSIRIVDFRPPNRADMLHDPATQVEFVQTDVSSTEATDKAFRKPWHPSVAHLPLTVFHTAAVIVPSDRSKLVSGFCEAVNVLGTQNVVDAARRAGADVLVSTTSASISIRPIEIWVPPWRLWSRGSPRHSWQVLDERDFFEPLRTHEEFYANYPASKAAAERLVCAANSRGLRTGCIRPANGVYGNPTDNTVGGALAKAVFPTWTSHVVQSFAHGINVAIAHLDFEAVLATPASASSPQAGRPFVITDPNAPISYGDLNFLIQTLAITPFQVLPLQPVIMVLLSYPIEWYSLALAKYAFLRKLLPELTGEVKHLKPGIFSICTHLVASNEVASRPVSSGGLGYTGVLTTLEGMTQEVVEWNRDHRDTAGGRKLYQTSVSFADEMAKAVAAVEPVAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PEU0</accession>
    <name>A0AAN6PEU0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_16402</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854395">
        <property type="protein sequence ID" value="KAK4039669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PEU0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF6">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4039669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="621" mass="69747" checksum="817E078399A3E169" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PEV6</accession>
    <name>A0AAN6PEV6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_46957</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854396">
        <property type="protein sequence ID" value="KAK4039626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PEV6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053181">
        <property type="entry name" value="EcdB-like_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="11"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4039626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="562" mass="62294" checksum="412CF7D39655561D" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PF16</accession>
    <name>A0AAN6PF16_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nicotinamide-nucleotide adenylyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_47533</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854416">
        <property type="protein sequence ID" value="KAK4038893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PF16"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000309">
        <property type="term" value="F:nicotinamide-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31285">
        <property type="entry name" value="NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31285:SF0">
        <property type="entry name" value="NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4038893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="331" mass="36047" checksum="D3DD1FA21739894A" modified="2024-10-02" version="1">MPLQPPLSPRPVADFFTRALSSFRNSASKLQVICTAAPSPHRGGLDDGEPAALPPRVRPRTLIVLDSSFNPPTRAHLRMATSAIHALTHNQGQSPDALRLLLLLSVNNADKGAKPAAFDKRLAMMWAFARDVQHHLQTAPRNGQAGPGAEALSVDLGLATAPYFHEKSAALAESGFYSGEKNTDGVAETEQVFLVGYDTLIRIFNPKYYGPLESTGQVSTAESPPMQRALGPFFARSKLRVTMRTGDEWGGADEQTAYLQDLMQAEGLSKVGGNTDWAGRIEMVEGRKVGADIISSTYARGAAKERDSDRLDLMVTPEVRWWIEQGDLYTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PFA1</accession>
    <name>A0AAN6PFA1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_46639</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the APC3/CDC27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854388">
        <property type="protein sequence ID" value="KAK4039909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PFA1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007091">
        <property type="term" value="P:metaphase/anaphase transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF13">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 27 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12895">
        <property type="entry name" value="ANAPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="127"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="584"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="618"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="652"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="686"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="193"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="266"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="412"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="220"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4039909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="798" mass="88147" checksum="17E5F36A60E5B93B" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PFE5</accession>
    <name>A0AAN6PFE5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_38105</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854444">
        <property type="protein sequence ID" value="KAK4035421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PFE5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043033388" evidence="3">
        <location>
            <begin position="18"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="296"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="252"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="274"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4035421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="314" mass="32064" checksum="36220B636F0098FD" modified="2024-10-02" version="1">MARRFLAALALAHGATALLEGFVDVLVEVNEVQVAPDIFAGIMQAAAGSDDGYDACVTADAILTSCYDAAYFAPTPPADGGNRCVCCDGTTAVSAVFASCASYALTSATSAYRVVSQIYSICADRAVCGTSGSARATAPGPASSLSLPPVCSSMLRIYSSCGADPDIRTATAPRDVAACFCPEESGSINTAFEDYASSCAPFLRSSFPADYSIVTQLATYCDAYQNQPLTSTGKRLVFTTAGTRTDGVFALPSATSASSPTGGTQKTPGIADGTESTQTTSSSTGLAAPGLPVPGFVAWFANLATLFLSFFILI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PFI3</accession>
    <name>A0AAN6PFI3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein HGH1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_16922</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HGH1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854412">
        <property type="protein sequence ID" value="KAK4039030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PFI3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039717">
        <property type="entry name" value="Hgh1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007206">
        <property type="entry name" value="Protein_HGH1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007205">
        <property type="entry name" value="Protein_HGH1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13387">
        <property type="entry name" value="PROTEIN HGH1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13387:SF9">
        <property type="entry name" value="PROTEIN HGH1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04063">
        <property type="entry name" value="DUF383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04064">
        <property type="entry name" value="DUF384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein HGH1 N-terminal" evidence="4">
        <location>
            <begin position="94"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Protein HGH1 C-terminal" evidence="5">
        <location>
            <begin position="283"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4039030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="354" mass="40044" checksum="7231C3E8FBD9029C" modified="2024-10-02" version="1">MPTELEELVGFIAHPNPQIRKLATENLVPYSTEQPAIFKTDELLPVKHLKFLIRDHPEIAEHALTILINLTADQSVLEFVATDDRFLGILLGNLVDPAEPNANLLAMLLANMAKWDDLKSIATRKQEVPAALQSNELVLNQLLDLFVKGADGTYNKQADFDYLAYVLADLSKHPEIRQFFISKQEYDGVVPINKIKVFTEHKSDIRRKGVASTIKNVAFDVPAHPAFLDEDQINIMPYLLLPITGSEQYDDEEMMGMLPDLQLLPPDKQRDPDHNIVQTHVETLTLLTTTREGRDLMRQINVYPIVRETHLRVDDEGVREACDRLVQVLMRDEAEPGAEGIAEDDGEDERIVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PFI9</accession>
    <name>A0AAN6PFI9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DEAD/DEAH box helicase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_37998</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854441">
        <property type="protein sequence ID" value="KAK4038039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18025">
        <property type="entry name" value="DEXHc_DDX60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001039">
        <property type="entry name" value="ATP-dependent RNA helicase DDX60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052431">
        <property type="entry name" value="SKI2_subfamily_helicases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059032">
        <property type="entry name" value="WHD_DDX60"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44533">
        <property type="entry name" value="DEAD/H RNA HELICASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44533:SF4">
        <property type="entry name" value="DEAD_H RNA HELICASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26076">
        <property type="entry name" value="WHD_DDX60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="738"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="1188"/>
            <end position="1367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="508"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1168"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1701"/>
            <end position="1793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="523"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1183"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1731"/>
            <end position="1741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1751"/>
            <end position="1767"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4038039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1816" mass="199719" checksum="963DEDC58CDA1896" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PFU1</accession>
    <name>A0AAN6PFU1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_46476</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854383">
        <property type="protein sequence ID" value="KAK4040158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PFU1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.60.10:FF:000012">
        <property type="entry name" value="Cellular nucleic acid-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.60.10:FF:000016">
        <property type="entry name" value="Cellular nucleic acid-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.60.10:FF:000085">
        <property type="entry name" value="Zinc knuckle nucleic acid binding protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051714">
        <property type="entry name" value="Znf_CCHC_NABP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23002">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="29"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="53"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="79"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="128"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="147"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="176"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4040158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="223" mass="23157" checksum="1AD59DD6DF90A02C" modified="2024-10-02" version="1">MSSVSRRACYKCGELGHHAEACASPQRLCYNCKQPNHESNECPMPRTTKAKQCYHCQGLGHVQAECPTLRLSGAGAGNRCYNCDSIGHLARNCPNPPVPGLARGPAVGRGGFAPQRGGFVGGPRPATCYKCGGPNHFARDCQAQAMKCYACGKLGHISRDCTAPNGGPLNTAGKTCYQCGEAGHISRDCGKKAGANGEMQPDVDMSGAQAMPAPAVAPVAPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PG44</accession>
    <name>A0AAN6PG44_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_47797</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854424">
        <property type="protein sequence ID" value="KAK4038596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PG44"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022085">
        <property type="entry name" value="OpdG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053204">
        <property type="entry name" value="Oxopyrrolidines_Biosynth-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38797">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP85-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12311">
        <property type="entry name" value="DUF3632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4038596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="254" mass="27721" checksum="3B55BD28AA561ABA" modified="2024-10-02" version="1">MSNNALALLEPLTDPSATAATVQAAVQGLNDEALASPADVDNLLWDAFETLFDVVGRTPPERQGRLLEFLTQLQQTKAKDAEGKVLKQGDGDGEVWADLPTFGWVAREKWNFDETDPSATPQQRAQWENWTAFLAQLTAQWADDARPGGADFSMFALWALRAALEADGGAASQTAVRLAALWVCYAGAHLRKLSADGHALPARCGVPDGKYDGHDWWGFNEDRWRAWGEELMAAQGKLEPDEVIQGAVKLMGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PH66</accession>
    <name>A0AAN6PH66_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Tricarboxylate/iron carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">C8A01DRAFT_36078</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sideroflexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854388">
        <property type="protein sequence ID" value="KAK4039945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PH66"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015075">
        <property type="term" value="F:monoatomic ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990542">
        <property type="term" value="P:mitochondrial transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004686">
        <property type="entry name" value="Mtc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11153">
        <property type="entry name" value="SIDEROFLEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11153:SF6">
        <property type="entry name" value="SIDEROFLEXIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03820">
        <property type="entry name" value="SFXNs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="301"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="224"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK4039945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="350" mass="37226" checksum="B2CF1C70F1DDCAA8" modified="2024-10-02" version="1">MSASLPGSRALPDSQYDLSTYWGRVRHTAGITDPRTLLVGSAGLEQAKKTLIAYKQGQIQSMTPELWRAKKIVDSTLHPDTGEAVFLPFRMSCFVLSNLVVTAGMLTPNLGNRGTIAWQVANQSLNVAINYSNSNKSSPLSWSKIAQSYFLAVTASCSVAVGLNSLVPRLKSLSPSTRLILTRLVPFAAVASAGALNVFLMRGEEMRTGIDVFPAASKASPAAAAALEKPQDGGGSQQTEGTAEKSLGKSKKAATLAVAETAASRVFNSSPIMVIPPLVLVRLQGAAWLRSNPRWTLPVNLGLILVTSYAALPLALAAFPQRQRLRAESLEPEFHGRGGEGGLVEFNRGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PHV5</accession>
    <name>A0AAN6PHV5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SWIRM domain-containing protein FUN19</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_46274</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854378">
        <property type="protein sequence ID" value="KAK4040378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PHV5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000087">
        <property type="entry name" value="Transcriptional adapter 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007526">
        <property type="entry name" value="SWIRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12374:SF21">
        <property type="entry name" value="SWIRM DOMAIN-CONTAINING PROTEIN FUN19-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12374">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTOR 2 ADA2 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04433">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50934">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SWIRM" evidence="2">
        <location>
            <begin position="322"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4040378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="423" mass="47037" checksum="99EA1FF1DD44AEF2" modified="2024-10-02" version="1">MQVPASHDRNQTATRPPWAPSSSPPTYLPPTPTKEMQDVCALPPDRHPSMAAKQQKPCDISNLMSPPEPAPLDMFKSAGLASGKPAPAPEARVPHQPLSPPVSPFSQAANTINPAPPLNLSGKDPILYPASEPSTTAPTGPLFTPTPASVENFRATTERLVSEHIASRPVGLFRGSTPPRPEDYELALYFKSNCFRMFQDNPKEWLRKERELLRADRKHTALSFQPTRLPHILPASRPAVLGPQSTKAPMVRVQKPKSPKAKTQNPRPIRATPAPASRETIRVGTPEPRVRTVAPNREDKDFASLEDLAPPVSTLPSKPNSLKVDWKGNALDLSGDPHRHLLHPDELILASNLRLDCATYLTSKRRIFLRRLECARIGKEFRKTDAQQACKIDVNKASKLWQAYERVGWLDVEWMREYMGRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PIB7</accession>
    <name>A0AAN6PIB7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_36315</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854394">
        <property type="protein sequence ID" value="KAK4039691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PIB7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08284">
        <property type="entry name" value="FDH_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813:SF2">
        <property type="entry name" value="DEHYDROGENASE, ZINC-CONTAINING, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02810)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="6">
        <location>
            <begin position="15"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4039691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="359" mass="38543" checksum="CCE2E9C7935C2A38" modified="2024-10-02" version="1">MSNLPATMKAVVFHGPKQIAVEDRPVPKLQDPKDIIVKVHSTALCGSELHVYRGHQPSPTGFIMGHEFVGTVVQAGSEVKSVAPGDKVVTPFTVSCNSCFYCTHGASARCAHVQLFGSPTLDGGQAEYVRIPHADGTVLKTPSEITDDRALILMADIFPTGFFGAKNAFGMLQPQQPASEAVVVVIGCGPVGLCAIVSAMEYKPRHVFAVDSVPARLEVARGLGAEPLNFLGEGGKEAMLKRVREVTGGRGADAVIEVVGLSPALRTAFELVRPFGVISSIGVHNAEIPWSGNEAYGKNLRVQMGRCPVRSIFPEALPVLAKNQDKFSFMFDKIMPLSEAVEGYDLFDQMKVQKVIFKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PID5</accession>
    <name>A0AAN6PID5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_14932</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854360">
        <property type="protein sequence ID" value="KAK4041297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PID5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4041297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="415" mass="46558" checksum="78922593FD6C6C3A" modified="2024-10-02" version="1">MAGSPPGAPGPSRRSSRSPSHSRASSRSSTSTSSSERDQADITARLQLLARDAKASRVPFENDRSQHYRVFCRAICNLLSTELALFTFAQSIDGLPTSDVAWDRRYPDLHGEHPIEQHEDICPGVFDRARQLRQDFGPGVLSFDPKALRSFRKSPPGSRLFNTRLIELVAVAMHEIGALLFQLGLQMHQGDIEAVDQWREKPDELLPVVVPPRPTIFNHHGYLDHDLYPDGVADVVGYWAEDRILGGVTVFDRQSEQRAPQFPPNVYFHSCRAKLTKRYYQLRDDQQQALLDFLVAENPDPSRSPLPITADRRNVVRVNEEEAVLRHFYRDVWEHKAPTQEDLKFLERAPRNVDYPEYEGFIKRLNTNFGAVTITVPSGPRGNDAPNDKGGDDKAGSAIGEGQGSKRNGGPEDNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PJW2</accession>
    <name>A0AAN6PJW2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_33913</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854347">
        <property type="protein sequence ID" value="KAK4042027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PJW2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4042027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="161" mass="17281" checksum="C3617F48AEDDD043" modified="2024-10-02" version="1">MRTHPNSPYTPQPPSSTCASHSSNKIQFYTTLCTLAAAGLAAAAPASAHLDVRADTFWELTGFGNPQCQGSNLWTYQGTGNACINVKTFAASFRYEFHQNTKVELINFPTCGLSGVASTEADATNTTSIDFEGRDDNSALAARDFNGCQNDSLQAFRVTIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PKI6</accession>
    <name>A0AAN6PKI6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S26</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_35175</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS26 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854369">
        <property type="protein sequence ID" value="KAK4040801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PKI6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1740.20:FF:000001">
        <property type="entry name" value="40S ribosomal protein S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1740.20">
        <property type="entry name" value="Ribosomal protein S26e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000892">
        <property type="entry name" value="Ribosomal_eS26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047864">
        <property type="entry name" value="Ribosomal_eS26_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038551">
        <property type="entry name" value="Ribosomal_eS26_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12538">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12538:SF0">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01283">
        <property type="entry name" value="Ribosomal_S26e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00733">
        <property type="entry name" value="RIBOSOMAL_S26E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="87"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="111"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4040801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="120" mass="13716" checksum="27003D6E7A4FF043" modified="2024-10-02" version="1">MVKKRKNNGRNKKGRGHVKPIRCSNCSRCTPKDKAIKRFTIRNMVESAAIRDISDASVFSEYTVPKMYLKLQYCVSCAIHGKIVRVRSREGRRNRAPPPRVRYNKDGKKVTPTQQGPKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PL54</accession>
    <name>A0AAN6PL54_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_33156</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854336">
        <property type="protein sequence ID" value="KAK4042762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PL54"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42055">
        <property type="entry name" value="YALI0E03476P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42055:SF1">
        <property type="entry name" value="YALI0E03476P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="471"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="525"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="631"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="652"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="673"/>
            <end position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4042762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="682" mass="75447" checksum="95F4C0016EB8A9CC" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PLA6</accession>
    <name>A0AAN6PLA6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 13">Cytochrome c oxidase subunit 6, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 13">Cytochrome c oxidase polypeptide VI</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">C8A01DRAFT_44091</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Mitochondrion inner membrane</location>
            <topology evidence="1 13">Peripheral membrane protein</topology>
            <orientation evidence="1 13">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the cytochrome c oxidase subunit 5A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854334">
        <property type="protein sequence ID" value="KAK4042872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PLA6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00923">
        <property type="entry name" value="Cyt_c_Oxidase_Va"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.40:FF:000001">
        <property type="entry name" value="Cytochrome c oxidase subunit VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.40">
        <property type="entry name" value="Cytochrome c oxidase, subunit Va/VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003204">
        <property type="entry name" value="Cyt_c_oxidase_su5A/6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036545">
        <property type="entry name" value="Cyt_c_oxidase_su5A/6_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14200">
        <property type="entry name" value="CYTOCHROME C OXIDASE POLYPEPTIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14200:SF11">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 5A, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02284">
        <property type="entry name" value="COX5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48479">
        <property type="entry name" value="Cytochrome c oxidase subunit E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0349">Heme</keyword>
    <keyword evidence="8 13" id="KW-0408">Iron</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 13" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00070174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00082700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU368103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK4042872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="160" mass="17781" checksum="7AA325C1FF8E614C" modified="2024-10-02" version="1">MSASLLRVAARGPSSFLRANLVAARPQPMAARAGLAVPSLSSSSFSTSARLRSEHQEETFEEFSARYEKEFDGVQDVFELQRNLNNAFAYDLVPSPAVVSAALRAARRVNDFPTAVRIFEGIKAKVENKGQYEQYLTELKPLREELGIALKEDLYPEEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PLB4</accession>
    <name>A0AAN6PLB4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_33783</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854345">
        <property type="protein sequence ID" value="KAK4042150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PLB4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45782">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45782:SF4">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="4">
        <location>
            <begin position="178"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="378"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="390"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4042150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="415" mass="44852" checksum="97437E38F38918CE" modified="2024-10-02" version="1">MAPPISTITAKAAAKKAAVFTAGRAAFQPRQTYEVSSDIPRSFYLGHHRAGLERMRQTLATIGLIIECRDFRVPITCWNQHLEQSLAATAPSERARIIVYTHRDLGPDITPSPTIPSLSETAARHLRDFHLQNKHANEVLFTGTSSGNSTSYKPPIKALLTAIKSVARQRDSLTGLRALVVGMPNAGKSTLLNNLRRVFAHKRGGGAVPKVARTGAEPGVTRKLSNPIRVVGAEGKSRASDASLEGVGEGVFVVDTPGVFVPYIGDPEKMVKLALVGCVRDGIIPRETLADYLLYRLNLAGVYEQRAYMARLRMDAPTNDVTEFLTAVAMRVGKLGQGGRPNLLAAAEWVVQEWRSGGIGKAILDDVTPETLAKAMEEAKETELSMNQAKKREKEARKARNEAKRSGVAGGGDGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PLW9</accession>
    <name>A0AAN6PLW9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_35072</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854367">
        <property type="protein sequence ID" value="KAK4040900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PLW9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053178">
        <property type="entry name" value="Osmoadaptation_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111:SF9">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="10"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="56"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="366"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="387"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4040900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="582" mass="63004" checksum="5D5DDCD31BD9EB4C" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PM27</accession>
    <name>A0AAN6PM27_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">LYC1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_15229</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854366">
        <property type="protein sequence ID" value="KAK4040990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PM27"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055100">
        <property type="entry name" value="GNAT_LYC1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053013">
        <property type="entry name" value="LAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34815">
        <property type="entry name" value="LYSINE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34815:SF4">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22998">
        <property type="entry name" value="GNAT_LYC1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LYC1 C-terminal" evidence="1">
        <location>
            <begin position="175"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4040990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="369" mass="40971" checksum="3A3B0200CCDA2D48" modified="2024-10-02" version="1">MSPPEPPAQPPITKADVVFTEATPHQRTLSWELNGASWAPPMTIEQYVGRETALSETALSAAGGTKYFILHPKDDPETIVSACEVTSKKALVSDANGTREVAAYAIASVFTNPLFRERGMAGHMLRKVQEAVDATAEYGALYSDIGRMYYTRLGWKDFRSPQVLVGLSEDLTCPSLDGVALLTAKEVAPLCEEDVAAVRARFEQRAQSGDDGKTHIAFLPTAEQMAWHFTRDAYVCKTLLGREVVHRGAKTGDGAAWIYWDHDLREKKLKVLRIVTRDGDDPEKQREDVKKLLLAALAEAREWGLLKVLVWNPTVGVADVATEIWREVGPRVHVSFEEREDGSIPSLRWKGGKGLADVVWESNEYYAWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PMF5</accession>
    <name>A0AAN6PMF5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Flavodoxin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_45611</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854362">
        <property type="protein sequence ID" value="KAK4041170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PMF5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000034">
        <property type="entry name" value="NADPH-dependent diflavin oxidoreductase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF10">
        <property type="entry name" value="NADPH-DEPENDENT DIFLAVIN OXIDOREDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="8">
        <location>
            <begin position="21"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4041170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="746" mass="83645" checksum="76AAC1802CECC397" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PNP1</accession>
    <name>A0AAN6PNP1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribosome biogenesis protein SLX9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_42825</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLX9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854319">
        <property type="protein sequence ID" value="KAK4044394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PNP1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028160">
        <property type="entry name" value="Slx9-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15341">
        <property type="entry name" value="SLX9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="197"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="217"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4044394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="251" mass="26626" checksum="910F2050EAC7C9C7" modified="2024-10-02" version="1">MKCPSPTTIKILAALAGGMAPTAPAPSKRLTARQKARARLADPLLPRKLHREDNVVSDTFIDSKRDKRLIKHSSFISRVAKSSSAKGSSTTQKKRRRPSKKLVTTLESLGDALDDIQAEIRDEDEVVDADAMDAEQARQGKVRHKSLKSRPGALKRKERLVKGEMERFGRSLAQLANISTATAAAAAGTTATATAAKGAGAGQEKMDTEVPGGQGGAHTTAQSAATSGRWAALRGFISATMEQNPAFLGKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PQ81</accession>
    <name>A0AAN6PQ81_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_43762</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854329">
        <property type="protein sequence ID" value="KAK4043274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PQ81"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12614">
        <property type="entry name" value="RRM1_PUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12619">
        <property type="entry name" value="RRM2_PUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12622">
        <property type="entry name" value="RRM3_PUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000117">
        <property type="entry name" value="Nuclear and cytoplasmic polyadenylated RNA-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000224">
        <property type="entry name" value="Nuclear and cytoplasmic polyadenylated RNA-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000134">
        <property type="entry name" value="Nuclear and cytoplasmic polyadenylated rna-binding pub1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48038">
        <property type="entry name" value="RIBONUCLEOPROTEIN RB97D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48038:SF1">
        <property type="entry name" value="RIBONUCLEOPROTEIN RB97D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="90"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="180"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="306"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="375"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="435"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="439"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="490"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4043274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="501" mass="54444" checksum="4347F182AAC7BB21" modified="2024-10-02" version="1">MADNGPPTTSGQLPPPPQPNAGAPGYENGQNAGSNPSHMPPPPLHIPQNTNPIPTAMTSPMGAGGDKSGMMSPGSGGPFGRRAAPEPNKRALYVGGLDPRVTEDVLRQIFETTGHVQSVKIIPDKNAKGYNYGFVEYDDPGAAERAMQTLNGRRVHQSEIRVNWAYQSNSTNKEDTSNHFHIFVGDLSNEVNDEVLLQAFSAFGSVSEARVMWDMKTGRSRGYGFVAFRERPDAEKALSSMDGEWLGSRAIRCNWANQKGQPSMAQQQAMQQMGMTPTTPYGHHHFPTHGVHSYDMIVNQTPAWQTTCYVGNLTPYTTQQDIVPLFQNFGFVVESRFQADRGFAFVKMDTHENAAMAICQLNGYNVNGRPLKCSWGKDKTPSQTQQFDPNQQYSPQSAQTPGYPGTPSAYFNQYGGGRYPREAVILDSVVNDFPGSFNPGQQPGYAAPQAQSPAGYGAQPMGYSGPPSAGGYGRGQQSNAQQWNQPPPGQNFNNGFSGYQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PQK8</accession>
    <name>A0AAN6PQK8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">tRNA (guanine-N(7)-)-methyltransferase</fullName>
            <ecNumber evidence="11">2.1.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Transfer RNA methyltransferase 8</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">tRNA (guanine(46)-N(7))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">tRNA(m7G46)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">TRM8</name>
        <name evidence="13" type="ORF">C8A01DRAFT_13288</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>guanosine(46) in tRNA + S-adenosyl-L-methionine = N(7)-methylguanosine(46) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42708"/>
            <dbReference type="Rhea" id="RHEA-COMP:10188"/>
            <dbReference type="Rhea" id="RHEA-COMP:10189"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74480"/>
            <dbReference type="EC" id="2.1.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="10 11">tRNA modification; N(7)-methylguanine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Forms a complex with TRM82.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.33" evidence="11"/>
    <dbReference type="EMBL" id="MU854331">
        <property type="protein sequence ID" value="KAK4043156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PQK8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106143">
        <property type="term" value="C:tRNA (m7G46) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008176">
        <property type="term" value="F:tRNA (guanine(46)-N7)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000060">
        <property type="entry name" value="tRNA (guanine-N(7)-)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03055">
        <property type="entry name" value="tRNA_methyltr_TrmB_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025763">
        <property type="entry name" value="Trm8_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003358">
        <property type="entry name" value="tRNA_(Gua-N-7)_MeTrfase_Trmb"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00091">
        <property type="entry name" value="tRNA (guanosine(46)-N7)-methyltransferase TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23417">
        <property type="entry name" value="3-DEOXY-D-MANNO-OCTULOSONIC-ACID TRANSFERASE/TRNA GUANINE-N 7 - -METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23417:SF16">
        <property type="entry name" value="TRNA (GUANINE-N(7)-)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02390">
        <property type="entry name" value="Methyltransf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51625">
        <property type="entry name" value="SAM_MT_TRMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 11" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3 11" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="132"/>
            <end position="133"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="167"/>
            <end position="168"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="265"/>
            <end position="267"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00060552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK4043156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="291" mass="33638" checksum="DA0BE6A561163F7E" modified="2024-10-02" version="1">MGGDRIKKDKRQKREDYRAAMRKEDISELPRKKFYRQRAHANPFSDHQLIYPPHPDQMDWSSLYPHYVVDEPQDQQTPAALPETAPSDHDLAPLQPKRISKDVEVADIGCGFGGLLIALAPTMPDTLILGLEIRVSVTHFVEDRIKALRAQNQDARLYRNVGVLRANTMKFLPNFFRKAQLSKVFVCFPDPHFKARKHKQRIVSATLNSEYAYVLRPGGIVYTITDVPDLHEWMVQHFEAHPSFERVPEQEQEADPCVGIMRTETEEGKKVERHKGQKHVALFRRLEDPAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PQQ4</accession>
    <name>A0AAN6PQQ4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">UPF0587 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_43477</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0587 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854326">
        <property type="protein sequence ID" value="KAK4043529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PQQ4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008584">
        <property type="entry name" value="CXXC_Zn-binding_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007175">
        <property type="entry name" value="Rpr2/Snm1/Rpp21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12857">
        <property type="entry name" value="CXXC MOTIF CONTAINING ZINC BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12857:SF0">
        <property type="entry name" value="CXXC MOTIF CONTAINING ZINC BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05907">
        <property type="entry name" value="CXXC_Zn-b_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04032">
        <property type="entry name" value="Rpr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141678">
        <property type="entry name" value="MAL13P1.257-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="197"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="254"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="307"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4043529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="330" mass="35826" checksum="A79693C3DF5EC422" modified="2024-10-02" version="1">MYALTLSAELEGVTNLRPKDTQESNFFYTFKVQCTSCRETHPNPIAVNRFRESSATIKAAPNPYQQTEPAKAQKIIEFDCRGLEFTEFLPEGEWLADGIESNTKFDGVELSEGEWFDYDEKAGDEMTPAELTATLGFLTDAGHLLATAAPETSAYVMSQRNGLMLEHEMALTDKQRQHVCSCCGHIMLLGQGSELQVKAGQRASQKPRSTRAPKGNGAQKLPSRPQTCPGPTKAITCGHCGRLTNVKLPAPAPISRRKVKVEKATKASGRATSVPSTAQEMASQKTTSNASSKKRAKSRKAGLQALLDQSNASRNSGPGLGLSLADFMQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PQU5</accession>
    <name>A0AAN6PQU5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fungal-specific transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_31610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854320">
        <property type="protein sequence ID" value="KAK4044293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PQU5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="PANTHER" id="PTHR37540">
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        <location>
            <begin position="32"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="332"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4044293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="542" mass="60367" checksum="F7146DAFE4EBAF98" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="2">Uncharacterized protein</fullName>
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        <name evidence="2" type="ORF">C8A01DRAFT_32609</name>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854329">
        <property type="protein sequence ID" value="KAK4043291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PQV1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="127"/>
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    </feature>
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        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4043291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="127" mass="14385" checksum="FDEB4D7075773D8E" modified="2024-10-02" version="1">MANNANASANNKQPAAAKDSAQEEEQLEDMLYRLDQLRQLRSALPRMLEPLMTKHPSPQAAFAAYMQSVDSTNKEVASFQEAFLGLHTDGVFHRARAGQKNPKGLKQWRASEHPDWADPDRKRRRIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAN6PQZ6_9PEZI</name>
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        <recommendedName>
            <fullName evidence="2">Phenol hydroxylase-like C-terminal dimerisation domain-containing protein</fullName>
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    </protein>
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        <name evidence="3" type="ORF">C8A01DRAFT_32945</name>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854333">
        <property type="protein sequence ID" value="KAK4043000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    <dbReference type="InterPro" id="IPR012941">
        <property type="entry name" value="Phe_hydrox_C_dim_dom"/>
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    <dbReference type="InterPro" id="IPR038220">
        <property type="entry name" value="PHOX_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07976">
        <property type="entry name" value="Phe_hydrox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phenol hydroxylase-like C-terminal dimerisation" evidence="2">
        <location>
            <begin position="2"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4043000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="96" mass="10707" checksum="2E710FC05C18999E" modified="2024-10-02" version="1">MPKSEIEITDLPALLQDSRWTFYLDDIPEQDTRGSLCTNKWLGSLGPGEVAIVNVRPDGYVGSVGRWDSSIDDAGEDAAKWMDAYYERFLQVPAPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PR34</accession>
    <name>A0AAN6PR34_9PEZI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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        <name evidence="1" type="ORF">C8A01DRAFT_32537</name>
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    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854328">
        <property type="protein sequence ID" value="KAK4043411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PR34"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4043411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="72" mass="7718" checksum="BB7CA9E22B4DB748" modified="2024-10-02" version="1">MNPSQTTPATSPSASALRIFTRHPRLTIAGLAILGTGMGFRHVSRSYRQNEEAQKKSASNLYVTVDRSGGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PRF9</accession>
    <name>A0AAN6PRF9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_11952</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854317">
        <property type="protein sequence ID" value="KAK4044608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PRF9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01466">
        <property type="entry name" value="vWA_C3HC4_type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000014">
        <property type="entry name" value="von Willebrand and RING finger domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051266">
        <property type="entry name" value="CLCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10579">
        <property type="entry name" value="CALCIUM-ACTIVATED CHLORIDE CHANNEL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10579:SF43">
        <property type="entry name" value="ZINC FINGER (C3HC4-TYPE RING FINGER) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15411">
        <property type="entry name" value="PH_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="138"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="4">
        <location>
            <begin position="625"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="211"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="366"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="556"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="996"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="212"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="251"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="578"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1038"/>
            <end position="1048"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4044608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1164" mass="127075" checksum="CDC3139357480621" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PRL5</accession>
    <name>A0AAN6PRL5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PXA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_12567</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854322">
        <property type="protein sequence ID" value="KAK4044024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PRL5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045022">
        <property type="term" value="P:early endosome to late endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003114">
        <property type="entry name" value="Phox_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051837">
        <property type="entry name" value="SortingNexin/PXDomain-PKLike"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22999">
        <property type="entry name" value="PX SERINE/THREONINE KINASE PXK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22999:SF23">
        <property type="entry name" value="SORTING NEXIN-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02194">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00313">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51207">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PXA" evidence="4">
        <location>
            <begin position="112"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4044024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="447" mass="48750" checksum="009D539F5E9C3DB5" modified="2024-10-02" version="1">MTTAAAQPPPPPPARVPTPGPRPNPSRTSSLQSESTAASKTRLNQSSASTENAAQSQQPGGARRGGRAASADPLSDKTTAFLIRRILCPQQADKGRTSPASIEGLLPPLTSRNDVDLQLYALIAIILREFVQNWYAKITPDETFVAEIVQIIAHITRALEQRLRKVDLESLLFDELPDLLDKHVAAYRVAHDPIAQPPVRTDPREIYHSLCPLPALSPVPRPEDPESVAVQAENEAAYRQLLVHAFLAILLPTEDLENGCLTALVGQIFSELIIGNAVANRLSEPWLIWELLIIAARTAGRQKTAEAKDPLGQSNNASSAAKRRFSVHTLFWAVLQWCFLAISFIRTAFAILMTSASLPPRTSHGASLKGATRHETGQGSIRITSSFDADLHPPRTPVLAFRCWSAVSNLAEMDVRMPWLRGALSMLQWIAAMGPGRIASVDGRLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PS14</accession>
    <name>A0AAN6PS14_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_43236</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the secreted LysM effector family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854323">
        <property type="protein sequence ID" value="KAK4043861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PS14"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052210">
        <property type="entry name" value="LysM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997">
        <property type="entry name" value="AM15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997:SF1">
        <property type="entry name" value="PEPTIDOGLYCAN-BINDING LYSIN DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042892579" description="LysM domain-containing protein" evidence="4">
        <location>
            <begin position="35"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="5">
        <location>
            <begin position="211"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="5">
        <location>
            <begin position="305"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4043861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="596" mass="64559" checksum="53D80CDC8A1EBDE6" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PTQ2</accession>
    <name>A0AAN6PTQ2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin-like protease family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_12249</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854319">
        <property type="protein sequence ID" value="KAK4044395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PTQ2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019784">
        <property type="term" value="F:deNEDDylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000338">
        <property type="term" value="P:protein deneddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.395.10:FF:000008">
        <property type="entry name" value="Ulp1 protease family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044613">
        <property type="entry name" value="Nep1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46468">
        <property type="entry name" value="SENTRIN-SPECIFIC PROTEASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46468:SF1">
        <property type="entry name" value="SENTRIN-SPECIFIC PROTEASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="6">
        <location>
            <begin position="23"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="221"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="221"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="237"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4044395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="247" mass="27975" checksum="EA1B328C2A78DDCD" modified="2024-10-02" version="1">MAKHFGDSLGMSSPKPYLSYHDIRLDTEDIKALKSDWLTDSAIAFWEEWLEREILPKYPQARIVLLRPVVSHLLMQTTDLQGDASALPDFRKVTHIFLPISDSRDRWNADSGSHWSLLLVSVIDRVAFHYDSLGGSNFSAAKRGVDRLSIVLGVPLRFHQLEDTPQQENSKDCGVFVCILMRHLLIKRLLNANSNEKVSMSMSGKMIDSRGGRKEMLRIVESLRKEGERRRSASPFAGSSNDPPRVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PU14</accession>
    <name>A0AAN6PU14_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nuclear pore complex protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_31364</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as a component of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
            <location evidence="7">Nuclear pore complex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the nucleoporin Nup84/Nup107 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854318">
        <property type="protein sequence ID" value="KAK4044575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PU14"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000973">
        <property type="term" value="P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3450.20:FF:000003">
        <property type="entry name" value="Nuclear pore complex protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3450.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.190.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007252">
        <property type="entry name" value="Nup84/Nup107"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13003:SF2">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13003">
        <property type="entry name" value="NUP107-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04121">
        <property type="entry name" value="Nup84_Nup100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="5 7" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0811">Translocation</keyword>
    <keyword evidence="1 7" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="88"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="90"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4044575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="946" mass="107496" checksum="16D9F0610D4E430D" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SLS8</accession>
    <name>A0AAN6SLS8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_50843</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854620">
        <property type="protein sequence ID" value="KAK4032354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SLS8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052600">
        <property type="entry name" value="Nuc_rcpt_coact/corep"/>
    </dbReference>
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        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
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        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23295:SF6">
        <property type="entry name" value="NEOSIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23295">
        <property type="entry name" value="NUCLEAR RECEPTOR COACTIVATOR 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="347"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="269"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="416"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="650"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="113"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="163"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="199"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="230"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="416"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="464"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="506"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="655"/>
            <end position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4032354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="794" mass="84627" checksum="E456725BFD46AEA9" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SMM7</accession>
    <name>A0AAN6SMM7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cohesin loading factor-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_50536</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SCC4/mau-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854580">
        <property type="protein sequence ID" value="KAK4032730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SMM7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019440">
        <property type="entry name" value="MAU2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21394">
        <property type="entry name" value="MAU2 CHROMATID COHESION FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10345">
        <property type="entry name" value="Cohesin_load"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="119"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="10"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="164"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4032730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="876" mass="96954" checksum="5A59112C90667568" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SMN1</accession>
    <name>A0AAN6SMN1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_20124</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854568">
        <property type="protein sequence ID" value="KAK4032878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SMN1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4032878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="215" mass="24142" checksum="063DA7F6228F331D" modified="2024-10-02" version="1">MVSGDSSLIHPSKSQCTISLGKDLGRVTTLAYRLVGHDSIHSFAENCEKTMGEWIALLGKTTLPSDIASSDPCIIVAFQAVDGVICGRGTYLLRRLAYVQLMRLFISLTAIIKSERENGRLHRNPCHRDATVAMDIYMSAQERRSNTRDLRRELQERKRFGRSWSDLAGPSPLFVLVYSDAAEPIVYVTFCPYPFSLINAKHLKGRTLKKRTPQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SMQ8</accession>
    <name>A0AAN6SMQ8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_19676</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854535">
        <property type="protein sequence ID" value="KAK4033359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SMQ8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37844">
        <property type="entry name" value="SER/THR PROTEIN PHOSPHATASE SUPERFAMILY (AFU_ORTHOLOGUE AFUA_1G14840)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37844:SF2">
        <property type="entry name" value="SER_THR PROTEIN PHOSPHATASE SUPERFAMILY (AFU_ORTHOLOGUE AFUA_1G14840)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4033359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="278" mass="30988" checksum="7D2DD844C6EAF8C7" modified="2024-10-02" version="1">MPPTAFQILSDLHLETHSYGYTIPQTAPNLALLGDVGQVANDALFVFLEKQLQRYWNVFFLLGNHEPVLGSWAAAKQRVREFAARMERLRAQSTIGRFVFLDQTRHDVNDTLTVLGCTLFSRVTQEQAAEVGSRLVDFNQIQNWAVEDHVDAHAANLRWLNEQVAAISTAEPQRQIVVFTHHSPSLDPRAVDERHRGSTVASGFATDLGEEECWTNRAVVMWAFGHTHFSCDFTDEFGKRVVANQRGYGMTPKAAFDAAKVFSVGRETGAGGPSMLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SMZ5</accession>
    <name>A0AAN6SMZ5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mucoidy inhibitor-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_39170</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854483">
        <property type="protein sequence ID" value="KAK4034346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SMZ5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011935">
        <property type="entry name" value="CHP02231"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037291">
        <property type="entry name" value="DUF4139"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025554">
        <property type="entry name" value="DUF4140"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02231">
        <property type="entry name" value="mucoidy inhibitor MuiA family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31005">
        <property type="entry name" value="DUF4139 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31005:SF8">
        <property type="entry name" value="DUF4139 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13598">
        <property type="entry name" value="DUF4139"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13600">
        <property type="entry name" value="DUF4140"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4140" evidence="3">
        <location>
            <begin position="19"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4139" evidence="2">
        <location>
            <begin position="303"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4034346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="792" mass="86684" checksum="EFE80B1A52DD883D" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SN08</accession>
    <name>A0AAN6SN08_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Dihydroxyacetone kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">C8A01DRAFT_40289</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-glyceraldehyde + ATP = D-glyceraldehyde 3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13941"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.28"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>dihydroxyacetone + ATP = dihydroxyacetone phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15773"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16016"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.29"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Polyol metabolism; glycerol fermentation; glycerone phosphate from glycerol (oxidative route): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the dihydroxyacetone kinase (DAK) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854542">
        <property type="protein sequence ID" value="KAK4033253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SN08"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004371">
        <property type="term" value="F:glycerone kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050354">
        <property type="term" value="F:triokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.340:FF:000001">
        <property type="entry name" value="Dihydroxyacetone kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1180.20:FF:000001">
        <property type="entry name" value="Dihydroxyacetone kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10440:FF:000001">
        <property type="entry name" value="Dihydroxyacetone kinase, DhaK subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10440">
        <property type="entry name" value="Dihydroxyacetone kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1180.20">
        <property type="entry name" value="Dihydroxyacetone kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012734">
        <property type="entry name" value="DhaK_ATP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004006">
        <property type="entry name" value="DhaK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004007">
        <property type="entry name" value="DhaL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036117">
        <property type="entry name" value="DhaL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050861">
        <property type="entry name" value="Dihydroxyacetone_Kinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02361">
        <property type="entry name" value="dak_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28629">
        <property type="entry name" value="TRIOKINASE/FMN CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28629:SF4">
        <property type="entry name" value="TRIOKINASE_FMN CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02733">
        <property type="entry name" value="Dak1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02734">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01120">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82549">
        <property type="entry name" value="DAK1/DegV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101473">
        <property type="entry name" value="DhaL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51481">
        <property type="entry name" value="DHAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51480">
        <property type="entry name" value="DHAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DhaK" evidence="15">
        <location>
            <begin position="10"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="DhaL" evidence="14">
        <location>
            <begin position="373"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="660"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="838"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="664"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="861"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-hemiaminal-histidine intermediate" evidence="11">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="56"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR612734-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR612734-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK4033253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1223" mass="132572" checksum="5E6DAD8CF69EF095" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SN81</accession>
    <name>A0AAN6SN81_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NLI interacting factor-like phosphatase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_39677</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854506">
        <property type="protein sequence ID" value="KAK4033869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SN81"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000089">
        <property type="entry name" value="NIF domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011948">
        <property type="entry name" value="Dullard_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02251">
        <property type="entry name" value="HIF-SF_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="2">
        <location>
            <begin position="328"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="197"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4033869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="524" mass="57891" checksum="A2AB4FF479C0AD44" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SNH2</accession>
    <name>A0AAN6SNH2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zinc transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">C8A01DRAFT_39709</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Functions as a zinc transporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endoplasmic reticulum membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854508">
        <property type="protein sequence ID" value="KAK4033822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SNH2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904257">
        <property type="term" value="P:zinc ion import into Golgi lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000014">
        <property type="entry name" value="Cation efflux protein/ zinc transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045316">
        <property type="entry name" value="Msc2-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45755">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45755:SF4">
        <property type="entry name" value="ZINC TRANSPORTER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="397"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="10">
        <location>
            <begin position="171"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="117"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="299"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="124"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="320"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="338"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU369017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK4033822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="537" mass="58575" checksum="131D59AE9ECD555B" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SNK6</accession>
    <name>A0AAN6SNK6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_49342</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854488">
        <property type="protein sequence ID" value="KAK4034244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SNK6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="19"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4034244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="238" mass="27202" checksum="8DDB05BC7568B1BC" modified="2024-10-02" version="1">MKRSSGQTAAPLPSGKRHCSTSPVKAGSDVLPNRVHRRIILSDCGIPIYRAGSRQVLLAALADCIEGHESLRQKAGLLYRDISLNNLMINKDNRGFLINLDLAINEQRVSASGAKAKTGTWAFMAIGALQGEQHSFIHDLESFFWKGRVISRFDKWNFVDTDERAEELAGLKLSVMSKEEMFMKMTTKYFTQYYQPLAPLVNSLRKVVFPEDKPWKREDERLYSRMGEMLRKEREDMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SNM7</accession>
    <name>A0AAN6SNM7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PPPDE putative peptidase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_38458</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DeSI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854456">
        <property type="protein sequence ID" value="KAK4035066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SNM7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101005">
        <property type="term" value="F:deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.30">
        <property type="entry name" value="PPPDE domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008580">
        <property type="entry name" value="PPPDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042266">
        <property type="entry name" value="PPPDE_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378">
        <property type="entry name" value="DESUMOYLATING ISOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378:SF80">
        <property type="entry name" value="IP06716P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05903">
        <property type="entry name" value="Peptidase_C97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01179">
        <property type="entry name" value="DUF862"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51858">
        <property type="entry name" value="PPPDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPPDE" evidence="5">
        <location>
            <begin position="23"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="180"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="211"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4035066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="254" mass="28116" checksum="71A1BA1AD38BE42A" modified="2024-10-02" version="1">MPTRKHQKKPSRSHRSTLSLQKTEILINIYDLLPPGRISSLLWHVGTSLLHSGVVINGKEYAYGGHDRRGLTGVYWTKPRTEPPGGTFRCEYLHGFTLAPHAEIDAIIREASEQFLGTGYNLLTRNCNHFTSFLCERLTGEPAPGFLNRAASIGVALPCVVPKEWIEVPDFDTAEGALLDEDEEAGGYESERARMLRSSGDQPRLVGQEDRDPELEWDSEEERQRGGSGKGKGKAPVRDSAGRMLPPAERAPIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SP15</accession>
    <name>A0AAN6SP15_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_39216</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854485">
        <property type="protein sequence ID" value="KAK4034288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SP15"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4034288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="200" mass="21567" checksum="4C1EEA82ED139D3C" modified="2024-10-02" version="1">MYLDGWEKIGDKMLPAAQRAAIVPLTFVTGVKRIECQVVVLAQDGTTQISNQDTFHAINASRSWGDDYLPSTIASSRLPRTPGGGGGGDPEPRWARGIKRDSVTSLGVASPGVLLDLQLLTTMLKQALAAMMSKGTSASYNIVTRRRVGRPSLQKARRPQLEPAKAGIWQDLAQLKKDAGLWNSELVSGDLTAPSFGPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SP19</accession>
    <name>A0AAN6SP19_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_39310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854489">
        <property type="protein sequence ID" value="KAK4034215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SP19"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47482:SF5">
        <property type="entry name" value="FAR1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47482">
        <property type="entry name" value="OS11G0632001 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="121"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="176"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="219"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="284"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4034215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="632" mass="70018" checksum="92AF8CFA89B62633" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SPM0</accession>
    <name>A0AAN6SPM0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Response regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_38474</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854456">
        <property type="protein sequence ID" value="KAK4035082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SPM0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339:SF1">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="196"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="415"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="363"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="374"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4035082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="606" mass="66290" checksum="07F05014887B741F" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SPM5</accession>
    <name>A0AAN6SPM5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycoside hydrolase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_48751</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854459">
        <property type="protein sequence ID" value="KAK4034978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SPM5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004348">
        <property type="term" value="F:glucosylceramidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006680">
        <property type="term" value="P:glucosylceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039514">
        <property type="entry name" value="6GAL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033452">
        <property type="entry name" value="GH30_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001139">
        <property type="entry name" value="Glyco_hydro_30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11069">
        <property type="entry name" value="GLUCOSYLCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11069:SF23">
        <property type="entry name" value="LYSOSOMAL ACID GLUCOSYLCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14587">
        <property type="entry name" value="Glyco_hydr_30_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17189">
        <property type="entry name" value="Glyco_hydro_30C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Endo-beta-1,6-galactanase-like" evidence="5">
        <location>
            <begin position="13"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 30 beta sandwich" evidence="6">
        <location>
            <begin position="326"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="79"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4034978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="416" mass="43979" checksum="BD8490695E4DA580" modified="2024-10-02" version="1">MVPFSKLVIVAAHLATLHQQIDGFGFSQAFGRAREFQQANASLQKAALDYLFSTSPGAGFSIIRNRIGSGASSDDSILPTNPGSPSSTPTYVWNNDDRGQVWFTKQAMSYGVKTIYADAWSAPGFMKTSGSEATVGYLCGTPGHACSSGDWRQAYANFLVKYVQLYADAGLPITHLGFLNEPDYEVSYSQMQISNNAAEAIDFIRVLAATVKAAGLSAKVIASQPLTSTPITGTSLRKWNTEGGPSGTFTTTWYSSGAANEGFTWANKLAVAMVKVELSAYLFWQGFQVENTASAMHLVDTLDGTTATPSGIFWAFAMWSRHIRPGAYRVATSGSMSNVITGAFVNTDGSVVVVFTNSGSSSQSAQVSFTGFTPTAASAWVTSNSAKFASTSASLSGGKVTVSVPGRGIVTVKLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SQ39</accession>
    <name>A0AAN6SQ39_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Short-chain dehydrogenase/reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_17502</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854430">
        <property type="protein sequence ID" value="KAK4038422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SQ39"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05374">
        <property type="entry name" value="17beta-HSD-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051911">
        <property type="entry name" value="SDR_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976:SF16">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4038422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="291" mass="31013" checksum="8B451690858DB91B" modified="2024-10-02" version="1">MAPRSRVWLITGCSSGFGLQLAQTAAARGDRVLAASRNPDKAKDLANQPNITLVRLDHNEDLPKIKEAINDIIAVHGTIDIVVNNAAYVQTGTIEEASPEDTLGQFQANLLGPLNLYRAVLPHLRSKGHGTLVTIGSMAAWYPMNSCNLYNASKAALRWAALGLGDEVKGFGIQHCLVEPGFFRTGLLKPGANLAGTPPATRLPAYDEINKAADGNFKQFNGKQLGNPVKGAEIIYEVVTSTGVAEGKALPEFLPLGSDATAEISKVAQKTLDAVEEWRSVSALSDFPEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SQT3</accession>
    <name>A0AAN6SQT3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_47573</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854417">
        <property type="protein sequence ID" value="KAK4038855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SQT3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF2">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="19"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="107"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4038855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="552" mass="62632" checksum="BFEE02EB2D478118" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SRK6</accession>
    <name>A0AAN6SRK6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_46894</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854394">
        <property type="protein sequence ID" value="KAK4039710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SRK6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="101"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4039710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="183" mass="19109" checksum="737816CCA6156BC6" modified="2024-10-02" version="1">MSSQPPSTPVKVPSSAANYTAATLDPDLRSQINSILIKEGHVTKIQDNLLHALHSHKSNWPTVIQNHALSMLRSGEVTSFPALLRRVLEDVRQDTAFSPSNAANNTTNGKAAATNGASDENGVNGSSSSSKKGDATNGAATTNGSNTGDRPSLAIPQTVVDEALKVTRDCLESVCEIDESGAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SS10</accession>
    <name>A0AAN6SS10_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Mitochondrial fusion and transport protein ugo1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_46574</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854386">
        <property type="protein sequence ID" value="KAK4039996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SS10"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="503"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="153"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="458"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="153"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4039996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="527" mass="56899" checksum="92C9BF4D42AA2CCC" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SSG8</accession>
    <name>A0AAN6SSG8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_46040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854372">
        <property type="protein sequence ID" value="KAK4040670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SSG8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039767">
        <property type="entry name" value="RALBP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12783">
        <property type="entry name" value="RALA BINDING PROTEIN 1 RALBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12783:SF5">
        <property type="entry name" value="RALA-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="2">
        <location>
            <begin position="405"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="579"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4040670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="653" mass="70874" checksum="840513729822AE6F" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6ST08</accession>
    <name>A0AAN6ST08_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphoethanolamine N-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_45560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854361">
        <property type="protein sequence ID" value="KAK4041210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6ST08"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF31">
        <property type="entry name" value="LAEA-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G01930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="25"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="53"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4041210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="375" mass="41219" checksum="AFE814F3B69601E1" modified="2024-10-02" version="1">MADVPAANSTPAANPAPVAVAPQAVNSSPAANSPPAANSAAAAEAPANTGILEADDDPADNDDADSALGVNAGDVSDTTSVMSSIFRYREQHGRTYHAYRDDTGQGNHGFKPYFLPNDETENERLDLQHNLAVLTQDSRLYICPAGKDKPLNRVLDAGCGTGIWAIDFGDEHPETSVVGVDISPSQPSFVPLNVEFFVDDLELEWNYVTPFDLIYARYLTGSIKDWPRFYRQAYQHLQPGGWIEVCDYVSPMACDDGTLKADSALKRWSDLLIEASVNLGATLASTVHYKQQMIDAGFQNVVQVEYKWPVNTWPKDPKHKEIGAWAHLNTMDALQALSYMSFTNGLGWSTVEVEALLVDVRKELKNRNIHAYWPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6ST32</accession>
    <name>A0AAN6ST32_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Beta-glucuronidase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_34837</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854363">
        <property type="protein sequence ID" value="KAK4041106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6ST32"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052974">
        <property type="entry name" value="GH79_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031728">
        <property type="entry name" value="GlcAase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183">
        <property type="entry name" value="BETA-GLUCURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183:SF2">
        <property type="entry name" value="BETA-GLUCURONIDASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16862">
        <property type="entry name" value="Glyco_hydro_79C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042927004" description="Beta-glucuronidase C-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="28"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-glucuronidase C-terminal" evidence="2">
        <location>
            <begin position="399"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4041106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="512" mass="54470" checksum="EDE613434FD5818E" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6STR2</accession>
    <name>A0AAN6STR2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Noc2p family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_14137</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854344">
        <property type="protein sequence ID" value="KAK4042247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6STR2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030690">
        <property type="term" value="C:Noc1p-Noc2p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030691">
        <property type="term" value="C:Noc2p-Noc3p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005343">
        <property type="entry name" value="Noc2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12687">
        <property type="entry name" value="NUCLEOLAR COMPLEX 2 AND RAD4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12687:SF4">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03715">
        <property type="entry name" value="Noc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="102"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="194"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="707"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="38"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="128"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="194"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="707"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="730"/>
            <end position="769"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4042247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="769" mass="85897" checksum="1288C40ACF0E4034" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2025-10-08" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6STU3</accession>
    <name>A0AAN6STU3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vacuolar membrane-associated protein IML1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Vacuolar membrane-associated protein iml1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_33107</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IML1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854335">
        <property type="protein sequence ID" value="KAK4042859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990130">
        <property type="term" value="C:GATOR1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04449">
        <property type="entry name" value="DEP_DEPDC5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045838">
        <property type="entry name" value="DEPDC5_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027244">
        <property type="entry name" value="IML1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048255">
        <property type="entry name" value="IML1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13179">
        <property type="entry name" value="DEP DOMAIN CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13179:SF8">
        <property type="entry name" value="GATOR COMPLEX PROTEIN DEPDC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19418">
        <property type="entry name" value="DEPDC5_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12257">
        <property type="entry name" value="IML1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEP" evidence="6">
        <location>
            <begin position="1323"/>
            <end position="1409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="508"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="544"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="709"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="834"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1415"/>
            <end position="1475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1675"/>
            <end position="1799"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1882"/>
            <end position="1901"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1927"/>
            <end position="1948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="41"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="722"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="736"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="834"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1457"/>
            <end position="1472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1683"/>
            <end position="1692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="1693"/>
            <end position="1708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1733"/>
            <end position="1758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1929"/>
            <end position="1948"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4042859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1948" mass="216194" checksum="6070A5B6F4695101" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SU34</accession>
    <name>A0AAN6SU34_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">C8A01DRAFT_44358</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="MU854338">
        <property type="protein sequence ID" value="KAK4042607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SU34"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14127">
        <property type="entry name" value="STKc_CK1_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000160">
        <property type="entry name" value="Casein kinase I 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000538">
        <property type="entry name" value="Putative Casein kinase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="13"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="305"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="355"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="305"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="363"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="391"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="417"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK4042607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="447" mass="50053" checksum="F3B73D7C08E0CC2A" modified="2024-10-02" version="1">MASSSSNVVGVHYRVGKKIGEGSFGVIFEGMNLLNSQQVAIKFEPRKSDAPQLRDEYRTYKILVGCPGIPNVYYFGQEGLHNILVIDLLGPSLEDLFDHCNRRFSLKTVCMVAKQMLSRVQTIHEKNLIYRDIKPDNFLIGRPGTKTANVIHVVDFGMAKQYRDPKTKQHIPYRERKSLSGTARYMSINTHLGREQSRRDDLEALGHVFMYFLRGGLPWQGLKAATNKQKYEKIGEKKQTTLVKDLCAGFPEQFEKYLNYVRGLGFEDEPDYNYLRGLFTEALQVAGQVEDGEYDWMRKQDKKGDWNRQALHDPNSRPGASAMELHGNSRGATTRHQSDPQAPGLTAARLNATQPPLPRQVMGQPPNQGRPNGPGLASPRSAAGGYMQAAPTPTGSTQAQFQNSTQNLPQRPMTQSPQMNTPAQPQNNPPQPQPTGFQKFMKTLCCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SUQ3</accession>
    <name>A0AAN6SUQ3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Elongator complex protein 4</fullName>
            <ecNumber evidence="6">4.6.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14 15 16">tRNA-intron endonuclease SEN34</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">C8A01DRAFT_44174</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. It probably carries the active site for 3'-splice site cleavage.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>pretRNA = a 3'-half-tRNA molecule with a 5'-OH end + a 5'-half-tRNA molecule with a 2',3'-cyclic phosphate end + an intron with a 2',3'-cyclic phosphate and a 5'-hydroxyl terminus.</text>
            <dbReference type="EC" id="4.6.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ELP4 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the tRNA-intron endonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.16" evidence="6"/>
    <dbReference type="EMBL" id="MU854335">
        <property type="protein sequence ID" value="KAK4042816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SUQ3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000213">
        <property type="term" value="F:tRNA-intron lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19494">
        <property type="entry name" value="Elp4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22363">
        <property type="entry name" value="tRNA-intron_lyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1350.10:FF:000008">
        <property type="entry name" value="tRNA-splicing endonuclease subunit Sen34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008728">
        <property type="entry name" value="Elongator_complex_protein_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036167">
        <property type="entry name" value="tRNA_intron_Endo_cat-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006677">
        <property type="entry name" value="tRNA_intron_Endonuc_cat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059049">
        <property type="entry name" value="TSEN34_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12896:SF1">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12896">
        <property type="entry name" value="PAX6 NEIGHBOR PROTEIN PAXNEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05625">
        <property type="entry name" value="PAXNEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01974">
        <property type="entry name" value="tRNA_int_endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26577">
        <property type="entry name" value="TSEN34_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53032">
        <property type="entry name" value="tRNA-intron endonuclease catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TSEN34 N-terminal" evidence="19">
        <location>
            <begin position="396"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA intron endonuclease catalytic" evidence="18">
        <location>
            <begin position="592"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="14"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="299"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="494"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="299"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="506"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="544"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="563"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00020265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00075884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00076724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00076863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF26577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAK4042816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="694" mass="74092" checksum="5E471CC129BD21D2" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SUU8</accession>
    <name>A0AAN6SUU8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase M50B-like-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_43574</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854327">
        <property type="protein sequence ID" value="KAK4043447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SUU8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049500">
        <property type="entry name" value="Peptidase_M50B-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33979">
        <property type="entry name" value="OS02G0221600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33979:SF2">
        <property type="entry name" value="PEPTIDASE M50B-LIKE-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13398">
        <property type="entry name" value="Peptidase_M50B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4043447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="281" mass="30344" checksum="ABD07C2831CC95EF" modified="2024-10-02" version="1">MPPPALRPTPRSWRAAAPHVARASAATTSAVLLSRRDLTVNDAQKVTLGIIAAYVVAIALLWNLPYVRWVLWPFKMLVIAFHEFGHAFACLLTGGRVKSISLDPREGGVTHMQGGRNAITLPAGYLGSSLIGALLTFAGFNINASKVASVIVGVCFLLTLWWGRRDWLTVGTVLAAVGLLVGCWFIAHAEALRFVVLFIGVMSSLYSVWDICDDLILRKVNSSDASVFAQRYGGSSQCWGVIWSIISLGFMAAGIVAGIAAFPQSAAQQREDSQHFIPTKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SUX6</accession>
    <name>A0AAN6SUX6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_32912</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854333">
        <property type="protein sequence ID" value="KAK4042968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SUX6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4042968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="104" mass="10823" checksum="C061C48188FA9118" modified="2024-10-02" version="1">MCTYTTHIRVCARCAREDTVLISEQLCLVAKASGIFGSCLEGVLCQRDATGYQCWQCKESVRVAVAVAVAAGRFGRGPRGRMGGKRGVGGGVVVGVGGVGGRWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SUY3</accession>
    <name>A0AAN6SUY3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1295 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_13260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854330">
        <property type="protein sequence ID" value="KAK4043205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SUY3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010721">
        <property type="entry name" value="UstE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251:SF23">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE (DUF1295)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06966">
        <property type="entry name" value="DUF1295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4043205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="365" mass="41174" checksum="2F873B64F09D780A" modified="2024-10-02" version="1">MALPVLHALEDCADFSQAVTPFLPQLYALPARVLGVLAGRESLLQLYTETNPLISGFAISVFLGAVFLVVAEINRNYSQVDRAWSLLPTLYIAHFDAWARLAGLPSQRIDAALLFSAIWSTRLTYNYWRKGGYGVGHEDYRWEIIRQQVPKAVFHVFNWTFISFIQSILLFMIAAPVYTILLASTIEPNLTSADIASVAIELGLILTEYIADEQQWAYQSAKKQYKDSAKVPRGFKQADLDRGFITSGLWGYSRHPNFAAEQSIWFFLYQWSCYASKTLYNWAGVGPSFLTLLFQGSTWLTELITAGKYPEYRDYQQSVGMFAPAGFSVYKAPAAAVKAAPRVIRTSDLAKKLQQKEKQKKPKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SV51</accession>
    <name>A0AAN6SV51_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_32065</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854324">
        <property type="protein sequence ID" value="KAK4043747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SV51"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042860744" description="Extracellular membrane protein CFEM domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4043747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="292" mass="28249" checksum="129C168FA60AAAA5" modified="2024-10-02" version="1">MKNIAISATLGYAALAQAQWWGGAPDCAHDCFSSYWSSSTAWPAPTTYCSASQGASVSSCIQSACSATPTAVTSYSSLSSSLCSQWSSCSSAGSTGVYTVSAPAFTGTNWPGPGNWGNGNGNGNGNGNGGNRGGYHNGNGNNNWDQWTRTWSGGAYTVIGCEWSGNVWAGGPGGCAPGSGGAGGSPWGPWGSGWSWSTVTQTVTQVLTVTDEAGATALSTSVGLAAVALAASGSVTSTSVIRAAETTGSSSGGASATGAVGSGAAAAAAAGAVGVKVWGAVLGGVVAVAALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SVI3</accession>
    <name>A0AAN6SVI3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_12841</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854325">
        <property type="protein sequence ID" value="KAK4043671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SVI3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="6">
        <location>
            <begin position="197"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="58"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="74"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="94"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4043671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="644" mass="70723" checksum="4F393D21193E2188" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SVK6</accession>
    <name>A0AAN6SVK6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">C8A01DRAFT_42607</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854317">
        <property type="protein sequence ID" value="KAK4044704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SVK6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00513">
        <property type="entry name" value="Ribosomal_L32_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.230.10:FF:000001">
        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000003">
        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044713">
        <property type="entry name" value="DNJA1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001515">
        <property type="entry name" value="Ribosomal_eL32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018263">
        <property type="entry name" value="Ribosomal_eL32_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036351">
        <property type="entry name" value="Ribosomal_eL32_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43888">
        <property type="entry name" value="DNAJ-LIKE-2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01655">
        <property type="entry name" value="Ribosomal_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01393">
        <property type="entry name" value="Ribosomal_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52042">
        <property type="entry name" value="Ribosomal protein L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00580">
        <property type="entry name" value="RIBOSOMAL_L32E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="11">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="12">
        <location>
            <begin position="142"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="9">
        <location>
            <begin position="142"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="395"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK4044704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="554" mass="61850" checksum="E9207526F1F91D3D" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SVM8</accession>
    <name>A0AAN6SVM8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">C8A01DRAFT_43315</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="MU854324">
        <property type="protein sequence ID" value="KAK4043748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SVM8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21776">
        <property type="entry name" value="MobB_Sid2p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05600">
        <property type="entry name" value="STKc_Sid2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000141">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000319">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000109">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF417">
        <property type="entry name" value="CELL CYCLE PROTEIN KINASE DBF2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="259"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="13">
        <location>
            <begin position="563"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="636"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="117"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="653"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK4043748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="664" mass="75627" checksum="3F3B5196A85BA76B" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SVR9</accession>
    <name>A0AAN6SVR9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_31416</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854319">
        <property type="protein sequence ID" value="KAK4044362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SVR9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006376">
        <property type="term" value="P:mRNA splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12611">
        <property type="entry name" value="RRM1_NGR1_NAM8_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12613">
        <property type="entry name" value="RRM2_NGR1_NAM8_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12346">
        <property type="entry name" value="RRM3_NGR1_NAM8_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000065">
        <property type="entry name" value="mRNA binding post-transcriptional regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000227">
        <property type="entry name" value="mRNA binding post-transcriptional regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000159">
        <property type="entry name" value="tRNA selenocysteine 1-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050825">
        <property type="entry name" value="RBM42_RBP45_47-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640:SF10">
        <property type="entry name" value="TRNA SELENOCYSTEINE 1-ASSOCIATED PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640">
        <property type="entry name" value="TRNA SELENOCYSTEINE 1-ASSOCIATED PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="41"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="134"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="270"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="339"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="385"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4044362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="398" mass="42355" checksum="CC058F9A687CDF12" modified="2024-10-02" version="1">MAEYTATGPGAATNGPNMNGSGDTTGFAPPAPMPSTNEAAKTLWMGEMEGWMDENFIKNIFSTVLGENVQVKVIRDRNSGNAGYCFIEFGTAEAAQKALNLNGTPVPNSTRVFKLNWASGGGLVDRRDDRGPEFSIFVGDLGPEVNEFVLVSLFQSRFPSCKSAKIMTDAMTGQSRGYGFVRFSDESDQQRALVEMQGVYCGNRPMRISTATPKTRSHQYGGQGQGGGNQMMPPVPGHPGPMWGAPAFYGQGAAFNPMQPMNQFTDPNNTTVFVGGLSGYVTEDELRSFFQGFGEITYVKIPPGKGCGFVQFVHRHAAEMAINQMQGYPIGNSRVRLSWGRSQNNSGVGTPYRPAPPPPHYMGGGMPPHGGPPGPGGPYGGPPFGGNPPQGPPPGPMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SVS2</accession>
    <name>A0AAN6SVS2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Kinesin light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_43254</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854323">
        <property type="protein sequence ID" value="KAK4043883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SVS2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4043883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="163" mass="18443" checksum="A00B51165DA3146A" modified="2024-10-02" version="1">MANLASTYQSQGRWKEVEPLEHPDTLFRMGNLAAKYWSQGRRNEAVSLQRQAVESSKRVLGEEHPDTLVLTSSLASAYADQCQWEETIELAIQVVRTSKWVLGEEHPDTLSRMTDLASFYSDHGQWNKAQPLQMQVIQASRRVLGEEHPAALGAIHNLAITWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SW64</accession>
    <name>A0AAN6SW64_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DUF221-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">C8A01DRAFT_31399</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854319">
        <property type="protein sequence ID" value="KAK4044346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SW64"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF5">
        <property type="entry name" value="RE44586P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="435"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="529"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="582"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="627"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="651"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="689"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="715"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="10">
        <location>
            <begin position="25"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="11">
        <location>
            <begin position="216"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="9">
        <location>
            <begin position="433"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="287"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="817"/>
            <end position="873"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK4044346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="873" mass="98059" checksum="DA3E667179D07330" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P460</accession>
    <name>A0AAN6P460_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_51491</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854819">
        <property type="protein sequence ID" value="KAK4031413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P460"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF130">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="307"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="397"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="434"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="463"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4031413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="506" mass="53429" checksum="89E9251B3EC40331" modified="2024-10-02" version="1">MGNPEPLSPGDAEKGPSQPGRDTDSLSLSAAGVDPEKRSGEDNGRVLGDTSDEEAAGGDQPPVSRQQTREEDGGNGVISRTLSRVVTRVSTKSSWNPGPPPDGGLQAWIAVACTHLVVMNTWGVVNSFGLFQTHYTAALGRSPSDISWIGSLQIFLLFFVGALTGRLTDAGYFRHVFALGAAFQILGIFAASAATQYWQVVLAQGICMGLGNGCLFCPCISTLSTYFDRRRSLAIGMAACGSATGGLVFPSLVRQLLPTQGFPAAMRAIGYVQVATFVVALVGLKQRIPARRSGPLVEWSAFREGEYTLYAAGSFSFFLGLYFAFYYVASFSREIIGMDYTSSLNLLLVLNGVGIPGRLIPNHLADRVGTINMLIPTCAIAGICVFCWMAVTSTAGLYVWCSFYGMVAGGIQSLFPAGLSSLTTDMRKAGVRMGMIFTIVSFATLAGPPIAGAIITASGGSYYGAQAFAGASLVLGMVLMAAARAVKVKRLMREADMTGAGWHVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P557</accession>
    <name>A0AAN6P557_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_41609</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854672">
        <property type="protein sequence ID" value="KAK4031953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P557"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4031953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="62" mass="7036" checksum="1CD3C0EB65F1E532" modified="2024-10-02" version="1">MGILWRDLKTDNVLINEDDDAVVLNFGGGNTMGWVDHDKYDSMEGKEQRLEKIMLALRVGPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P5C4</accession>
    <name>A0AAN6P5C4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_41512</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854656">
        <property type="protein sequence ID" value="KAK4032059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P5C4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF167">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="34"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="297"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="351"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="306"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="351"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4032059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="413" mass="44509" checksum="C5B00906EACB1881" modified="2024-10-02" version="1">MADAAEMPPDENRGPEILAVCGALVGLALVVVLLRIYVRARMVRHVGVDDWTIIAAMTVMFVEMMIIIPQVKIGGGRHVQYIKPPENVTKGLHLNFVTQPLCLIALCLTKVSVGFFLLRLTPSPRFRRIVIGTMVFTILSTTGNFLTVFFQCRPLALTWDPSVEGTCIPPSNLKFAAFFNSSVALLTDVLFALLPVPILWNVQMNWKVKSAVAAILSLGIFAAISAIVKITFLGSYGQHGDFLWDSADITIWTTVEINVAIIAASIPCLKPLFKTLLDGSSAARRYGSSKYKAYYMRNGRSGGGNSSTTNRTPKSKTRSGTGSTATATARSSSRGREPGFEMYAGQAKFTTDVQTGSRAPSATGSEESILPLGQGMQGAPPPPPPVEGGITKTSTVVVEFDEEERRRSIACAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P5E1</accession>
    <name>A0AAN6P5E1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptidase S8/S53 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_41482</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854651">
        <property type="protein sequence ID" value="KAK4032088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P5E1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF11">
        <property type="entry name" value="CEREVISIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S8/S53" evidence="5">
        <location>
            <begin position="39"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4032088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="290" mass="32106" checksum="0B48F202B4108FB5" modified="2024-10-02" version="1">MAEDLARNVRKQKTRDARKRSFDELNQLRALLLAGPGRRKVKVVVIDSGFSATWGSIPAPPSIAKSNYRDFVDGQHDVQRDESGHGTLTAHLVSMMLPEAVCELHVARVFRPPPSQQSWGPVEQAIGWAVEKGVDIILMAFGSSHDDDRVKRAINNLPDNMLFVTAAGNVPNFTRFFFPGRTQKNVMCVFAATASNKAAAELNPPPLNRGYNFALLGEPVLPEGIWSELQSATSYVAANAAAFAGLLLYFSWQPLPPGESEPLHLDDYLHEKMNLVFEELSSHHRDQGYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P5T4</accession>
    <name>A0AAN6P5T4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Mating-type protein MAT alpha 1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_20617</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the MATALPHA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854626">
        <property type="protein sequence ID" value="KAK4032298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P5T4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008301">
        <property type="term" value="F:DNA binding, bending"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045895">
        <property type="term" value="P:positive regulation of mating-type specific transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006856">
        <property type="entry name" value="MATalpha_HMGbox"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04769">
        <property type="entry name" value="MATalpha_HMGbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51325">
        <property type="entry name" value="ALPHA_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="1 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Alpha box" evidence="7">
        <location>
            <begin position="43"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4032298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="356" mass="39723" checksum="37335C399C9BE53F" modified="2024-10-02" version="1">MLCLGQQERASIIPPEPSKALPKKTSRLLSLSAMMRVENQRQPVKKKVNGFMGYRAYYSSLFSQLTQKEKSPIMTMLWKEDPSHKEWGFMCAVYSSIREFLSDENVSLQNWIQFAIKHMGIVVRESYLTTLGWKVVQLGKGTPKVERTTTRGVQSYLQPTNALELFMNCLNDGLPVANPLPIIATLSDLTNDIICVNTQVGAAAKPTNSIDSFCQPDKSQPYFTLPAHFEIAAAHPIIPQGVTVHRFLEISAFPAVAPFFMTGDGGSELNVMPERFLQDEGNDEIGSQANVGNQYFAMGMSNNTHGKYKLAVRNPDSNSIKSGPRPLAHPPFGPPKNPWHPPPYPIFHYKYCNQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P6A1</accession>
    <name>A0AAN6P6A1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_42294</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854960">
        <property type="protein sequence ID" value="KAK4031223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P6A1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000730">
        <property type="term" value="P:DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042148">
        <property type="term" value="P:DNA strand invasion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061982">
        <property type="term" value="P:meiosis I cell cycle process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942:SF66">
        <property type="entry name" value="RE19845P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942">
        <property type="entry name" value="RECA/RAD51/RADA DNA STRAND-PAIRING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="4">
        <location>
            <begin position="123"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="74"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4031223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="317" mass="33535" checksum="E1068D9B2017CA8F" modified="2024-10-02" version="1" fragment="single">MTDLLRVLPHFPVGQFARLIPALEKHGISTSDLLTLEAADIGKRTQLPLLDVRRLCGAVLDALHADLGVADLAPKPRVRQQAESGAEAGPEAEGPARPAPAHLDTQQPPTSALRNTADSLSVKWQTISTLDPALDRALGGGIPAGYVTEVTGESGAGKTQFLLSLLLSVQLPPPHGLGRPALYISTEAPLSTRRLAQMLAANPLFQRLPPAQRPSLDNIISTATPDLESQDHILTFQVPVEVERRGIGLIVVDSIAANYRAEFERAGGGKYGSNMGARSAELVKLGMHLRDLAQRHNLAVVVSNQVADRFTGGGGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P6C4</accession>
    <name>A0AAN6P6C4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_21500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854931">
        <property type="protein sequence ID" value="KAK4031253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P6C4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4031253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="55" mass="6175" checksum="BFAFAA224BD1AE9F" modified="2024-10-02" version="1" fragment="single">STIIEGHFTTKANIIEGLGAKLLIGTDFIVCNRVKINLTTITCHFRSIYNIRVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P6N4</accession>
    <name>A0AAN6P6N4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cysteine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cysteinyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">C8A01DRAFT_21047</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.16" evidence="2"/>
    <dbReference type="EMBL" id="MU854701">
        <property type="protein sequence ID" value="KAK4031792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P6N4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004817">
        <property type="term" value="F:cysteine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006423">
        <property type="term" value="P:cysteinyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00041">
        <property type="entry name" value="Cys_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015803">
        <property type="entry name" value="Cys-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024909">
        <property type="entry name" value="Cys-tRNA/MSH_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032678">
        <property type="entry name" value="tRNA-synt_1_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00435">
        <property type="entry name" value="cysS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890:SF3">
        <property type="entry name" value="CYSTEINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890">
        <property type="entry name" value="CYSTEINYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01406">
        <property type="entry name" value="tRNA-synt_1e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00983">
        <property type="entry name" value="TRNASYNTHCYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA synthetases class I catalytic" evidence="12">
        <location>
            <begin position="46"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="717"/>
            <end position="754"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK4031792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="813" mass="90845" checksum="5ABF994E3EA64F1B" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P780</accession>
    <name>A0AAN6P780_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_20782</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854649">
        <property type="protein sequence ID" value="KAK4032107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P780"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08267">
        <property type="entry name" value="MDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052733">
        <property type="entry name" value="Chloroplast_QOR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44013">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C16A3.02C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44013:SF1">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C16A3.02C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="20"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4032107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="346" mass="36466" checksum="3BAB206F2CE20254" modified="2024-10-02" version="1">MAATNVPKVMRAWQYSSIATTIENAIKLKELPLPLPPSGLGGDSILVKVYAASLNPADYKFPELPGFIARRIIPVPATPLLDFSGTVAAVGAQVSNFRVGQRVFGRMAPTSWGALGEYMAVTSKDAIVAELPESVSFEAGSGLGVAAQTSYQCIVPYVQAGDKVFVNGGSGGTGVFGIQIAKALGCHVTTSCSGRNADFCRSLGADEVIDYTTDDVSTVLRSKGQVFSLVFDTIGSSPADLYTAADAYLKPTGRFMQIGAAMSLAGTRSVMGRLLVPSILGGGKRKIKLATTKNTPGELDLLVRWVAEGKVKVPLDEVFPFDRAPDAFAKLRTGRARGKIVVKIVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P7A0</accession>
    <name>A0AAN6P7A0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_41420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854644">
        <property type="protein sequence ID" value="KAK4032137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P7A0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4032137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="396" mass="42559" checksum="848C30D5C336CFDE" modified="2024-10-02" version="1">MSTCRCFVCHWWPPTVGPPAHNGIVSVGRHRIEHDIPISPTDDSVPASNSAHVIMANQSIISLSPLGNIEHSFATLLPDGELVGMATFPQIGAKMQGDGDRDCDTVDSNNRPPPEDADMPPHSHQNVTTGGAALSGTPALGSPEALISLSHLNESISQQLVKFDSYPWDAPSAMQRLCSSKINTITDNPVAEALQTTTRFASILKSLSPSKSLETSSVPDSGVSVASSSHDGSIKGEINSRPGIAASSPLNTATYLLLLSSYLQLMHLFNVMFRRIAKFLGNMTEKAMSEFPQPEFRVTGLPPTMHSRLYLKILMQIIGHQLESVECLMGLSAEHCISGQAPLGKGIFSEQDVSNLLQAVLGQANSGRRLRRTVSEQPLIVSLRESIAVVQELLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P7C9</accession>
    <name>A0AAN6P7C9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">chitinase</fullName>
            <ecNumber evidence="4">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">C8A01DRAFT_40430</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="4"/>
    <dbReference type="EMBL" id="MU854551">
        <property type="protein sequence ID" value="KAK4033108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P7C9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF333">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="9 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="GH18" evidence="12">
        <location>
            <begin position="45"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK4033108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="906" mass="97324" checksum="2C34EB19496FE191" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P7F6</accession>
    <name>A0AAN6P7F6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_19962</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854556">
        <property type="protein sequence ID" value="KAK4033040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P7F6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05120">
        <property type="entry name" value="APH_ChoK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF15">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="157"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4033040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="260" mass="30076" checksum="FF68798FA9DB8767" modified="2024-10-02" version="1">MAAPRPQPPLLPQPTLTSEEGCLATSTDRKYYRRGNAFIKRCLRTREFLHGPQGIHIPRLRKESLKNEADTLRFIRRHTEIPVPLLFCDFEDDDAYYLITEYIEGVSMADLPDHQKDVVIAELEDHLARLKALKSNRMGGPSGIVIPPYRVLCETERDNWSQLRPSDHAEYVFCHNDCSQHNIIVNPETLKIAAIVDWEYAGFYPEYFEFAFYRRKGPSVALGEEEDDTDKLLDFLHSRLEWEGQGQHAPVSAHSYESYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P7V0</accession>
    <name>A0AAN6P7V0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_19669</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854534">
        <property type="protein sequence ID" value="KAK4033379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P7V0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4033379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="107" mass="11933" checksum="B66DDAEA62BB5F4F" modified="2024-10-02" version="1">MYAPRPTPISWPPFPRWQLISCSTTAPSSWPPTCPIPQLRLFFLRRNSSGISLYYVLFNLILSPELSTFAFLFVVNLGDVNSDVSVHGSSHTGDWIHLAQLAAVCVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P814</accession>
    <name>A0AAN6P814_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cytochrome b5-like heme/steroid binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_40124</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome b5 family. MAPR subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854531">
        <property type="protein sequence ID" value="KAK4033429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P814"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000003">
        <property type="entry name" value="membrane-associated progesterone receptor component 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050577">
        <property type="entry name" value="MAPR/NEUFC/NENF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281:SF115">
        <property type="entry name" value="BINDING PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G06240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281">
        <property type="entry name" value="MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="3">
        <location>
            <begin position="21"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4033429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="121" mass="13122" checksum="282309739D89E583" modified="2024-10-02" version="1">MAGKFEPKVPVQLAPPKDDPISLEDLAKANGEDGGKCYVAIKGIVYDVTGNKAYQPGGAYNVFAGHDASRALGKTSTKPEDVSPEWQDLPDKEKGTLNDWVTFFSKRYNVVGRVEGATNFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P8C8</accession>
    <name>A0AAN6P8C8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_50618</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854589">
        <property type="protein sequence ID" value="KAK4032630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P8C8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="596"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="439"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="743"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="760"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="776"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="810"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="825"/>
            <end position="841"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4032630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="851" mass="95991" checksum="D170A264CEF27FDC" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P8J1</accession>
    <name>A0AAN6P8J1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">6-O-methylguanine DNA methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_39837</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854514">
        <property type="protein sequence ID" value="KAK4033709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P8J1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052520">
        <property type="entry name" value="ATL_DNA_repair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42942">
        <property type="entry name" value="6-O-METHYLGUANINE DNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42942:SF1">
        <property type="entry name" value="ALKYLTRANSFERASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="Methylated DNA-protein cysteine methyltransferase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding" evidence="2">
        <location>
            <begin position="10"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4033709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="131" mass="13965" checksum="648BFE4E1423D245" modified="2024-10-02" version="1">MPRTDEAEAFFHAVYRAVQEIPPGRVTSYGHIARLIGTPQRPRQVGVCLKHLPSDPSARFHHGNVPWQRVISAKGVISPRAQLSGARNQAAALEGEAVTVTTGALGELMVDLGEFGWFPSVLPSEGGPGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P8U7</accession>
    <name>A0AAN6P8U7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">lytic cellulose monooxygenase (C4-dehydrogenating)</fullName>
            <ecNumber evidence="15">1.14.99.56</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">C8A01DRAFT_39672</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the polysaccharide monooxygenase AA9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="15"/>
    <dbReference type="EMBL" id="MU854506">
        <property type="protein sequence ID" value="KAK4033864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P8U7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF13">
        <property type="entry name" value="ENDOGLUCANASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="17">
        <location>
            <begin position="38"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAK4033864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="245" mass="26086" checksum="66D9CBC464B5B6CB" modified="2024-10-02" version="1">MAAPTNMDLFSAPIKHTHNSSTIKSTVLIALAVTAQAHTIFQSLSVNGADQGQLVGLRAPKSNNPIYDVIDQQLACGHPGSHSDKVINVKAGDRIGAKWGHVLGGAQRPNDRDNPIASSHKGPISTYMARVDNAATASPNGLKWFKIHEDGLDTRTGKWGVDNMIAAAGWAYATIPRCLAPGQYLLRQELLALHSAGSVVPSATVSIPGAYKQDDKGILLQIWVKDVPNNGRKAYTVPGPRPMSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P9Z7</accession>
    <name>A0AAN6P9Z7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_49125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854477">
        <property type="protein sequence ID" value="KAK4034501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P9Z7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4034501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="141" mass="15897" checksum="A2649E0859FD8BF3" modified="2024-10-02" version="1">MSTECKANRIKKVKPKVTSILRANYLLAAILSANELLTIRPCSAYEVRGLDSYEVSKTDSSRYTEYVRFKRSNYNVLNELLEAEERFEKIIRAISYSINTIEELERVEREEAEALAASEASTNPTPTSATPPLLGNDFVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PAD1</accession>
    <name>A0AAN6PAD1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">INO80 complex, subunit Ies4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_39784</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854512">
        <property type="protein sequence ID" value="KAK4033740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PAD1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013175">
        <property type="entry name" value="INO80_su_Ies4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28061">
        <property type="entry name" value="INO EIGHTY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28061:SF1">
        <property type="entry name" value="INO80 COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08193">
        <property type="entry name" value="INO80_Ies4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4033740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="266" mass="27058" checksum="5968F597933808B0" modified="2024-10-02" version="1">MAPSSKNAAAAAKDRRKSSNAAAATITSAASPKPTHIVTLKVPPQKLRAIVDPDFVKEDTPAKQSPAAAATSGTENASDSTPNSPPAGTPAAQSAAMGPPTEGPKKKGVKRSAAAAANGNGEPKVRGKPGPKKKQRLEDGTIEGGRGSLAAHKLGPKANQGAINAGLRALDRSGKPCRKWNRGGFTLKTFTGVVWEIPRWTAPPKPRPQDSAGGSTPASDSSNKENKEDASQIKSEASNNGGDVEMRGTPSFAADNSPAPAPIAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PAF9</accession>
    <name>A0AAN6PAF9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycine-rich domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_20504</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854612">
        <property type="protein sequence ID" value="KAK4032417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PAF9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009836">
        <property type="entry name" value="GRDP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34365">
        <property type="entry name" value="ENOLASE (DUF1399)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34365:SF7">
        <property type="entry name" value="GLYCINE-RICH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07173">
        <property type="entry name" value="GRDP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4032417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="792" mass="88344" checksum="CCD7ECA0D3968DB5" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PAN3</accession>
    <name>A0AAN6PAN3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Homeodomain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_50060</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854537">
        <property type="protein sequence ID" value="KAK4033323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PAN3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050560">
        <property type="entry name" value="MYB_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45614:SF25">
        <property type="entry name" value="MYB PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45614">
        <property type="entry name" value="MYB PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH myb-type" evidence="3">
        <location>
            <begin position="4"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="4"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="55"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="3">
        <location>
            <begin position="59"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="187"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4033323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="316" mass="35089" checksum="260B45137EAD042D" modified="2024-10-02" version="1">MLSEQALNKRNWEGKEDVLLLELHAAYGPNWTRIAGGMGIRSAKQCRERYTQHLKPGLNRSPISEDEGRQIMRMVSESGQRWAQIARSLGTNRSDNQIKNWWNGAKRKETSKRQEAGQEQPHNHHQHQQYPQDLSPSLGLAALPERRGILPPVPLELPFEVVARSRSSPARSYDSERPPSLVSDNGSSWSISQPASASCSPTTFSLPPLLFAPPTPPTGSCLPAAPSILNHGFGAGPVRRSSETVLQPSSYSPRSRYVNTAPTTPIGRTASTSSSSRWEPYPTKARRPSTGYYYQEHGHESESERRDKGSLSFLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PBD1</accession>
    <name>A0AAN6PBD1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Frag1/DRAM/Sfk1 family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_18903</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854487">
        <property type="protein sequence ID" value="KAK4034252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PBD1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000031">
        <property type="entry name" value="Calcofluor white hypersensitive protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019402">
        <property type="entry name" value="CWH43_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057315">
        <property type="entry name" value="Exo_endo_phos_PGAP2IP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051916">
        <property type="entry name" value="GPI-anchor_lipid_remodeler"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053912">
        <property type="entry name" value="PGAP2IP_TM_1nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053911">
        <property type="entry name" value="PGAP2IP_TM_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14859">
        <property type="entry name" value="CALCOFLUOR WHITE HYPERSENSITIVE PROTEIN PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14859:SF1">
        <property type="entry name" value="PGAP2-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23022">
        <property type="entry name" value="6TM_1st_PGAP2IP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23021">
        <property type="entry name" value="6TM_2nd_PGAP2IP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23226">
        <property type="entry name" value="Exo_endo_phos_PGAP2IP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10277">
        <property type="entry name" value="Frag1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
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        <location>
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        <location>
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        <location>
            <begin position="201"/>
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        <location>
            <begin position="280"/>
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        <location>
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        <location>
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        <location>
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            <end position="438"/>
        </location>
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        <location>
            <begin position="459"/>
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        </location>
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        <location>
            <begin position="500"/>
            <end position="517"/>
        </location>
    </feature>
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        <location>
            <begin position="524"/>
            <end position="542"/>
        </location>
    </feature>
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        <location>
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            <end position="227"/>
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            <dbReference type="SAM" id="Phobius"/>
        </source>
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        <source>
            <dbReference type="Pfam" id="PF10277"/>
        </source>
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        <source>
            <dbReference type="Pfam" id="PF23021"/>
        </source>
    </evidence>
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    </evidence>
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            <dbReference type="Pfam" id="PF23226"/>
        </source>
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            <dbReference type="EMBL" id="KAK4034252.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="965" mass="107261" checksum="DB6D69E7B3CECDA7" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PBE6</accession>
    <name>A0AAN6PBE6_9PEZI</name>
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        <recommendedName>
            <fullName evidence="4">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="5" type="ORF">C8A01DRAFT_48512</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854450">
        <property type="protein sequence ID" value="KAK4035245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PBE6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4035245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="426" mass="47199" checksum="2386BCBAC1B2A300" modified="2024-10-02" version="1">MPPTSLRVLISGGGIAGNALAFWLARQGHDITVVERFPSLRATGLQLDLRGPGIEVLRRMGLKEAFRAKAAPEQGMQVVDKSGRRRAYFPANKSGSGKQSLTSEFEMMRGDMCRLLYDAARAGKKPPQFVFGTSIDSFEQNNGTVEVRFEDGKTDQFDLVVGADGQWSRTRRMMLGTTAPDGMQRLPGLHMSYFTMPRPIEKGEEYLATSYMAPGRRGIMTRRHSPHEIQVLLSCMTNPDRLENVPKGDVQREKEVMAGIFEGAGWITEDIIKSMRAADDFYCERLGLVKLQFWSSGHVTLVGDAAHCPTVLSGMGTTCAMVGAYILAGEIGKYCGVNNDNEPNGIEMALKCYEEKFRPFVDRMQEGIAEKAESQWAMSGSAFGIATLNFLMGVASLFRVNVASIFSIRESVKSWNLPEYEHMLQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PBG9</accession>
    <name>A0AAN6PBG9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ankyrin repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_38526</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854458">
        <property type="protein sequence ID" value="KAK4035014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin repeat-containing domain"/>
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    </dbReference>
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        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
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        <property type="entry name" value="ANKYRIN REPEAT CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173:SF74">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4035014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="900" mass="99921" checksum="3FBB9943E8D1721D" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PBH3</accession>
    <name>A0AAN6PBH3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_19337</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854511">
        <property type="protein sequence ID" value="KAK4033758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PBH3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40640">
        <property type="entry name" value="ANCHORED GLYCOPROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40640:SF1">
        <property type="entry name" value="ANCHORED GLYCOPROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042884958" evidence="1">
        <location>
            <begin position="22"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4033758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="204" mass="21098" checksum="81055EEE01132F10" modified="2024-10-02" version="1">MRPQRPALLAWLCAAAGGAQGQSTVSVYLPEYDDSDWAALRGSVLSSDKSVTAYTVFCADQSPTCHIAGELPFVFTEGAHTLVYKGTDPGTLTADLECKLEGKTAATCTGSSSVGSHHREGPLTGPTETVWTKTFAAADVTWGVLTLSTPGPLPDTTDIEDTMLATMTGTAVPTSGARGLLDGESSRRVVMASLGAVVLGLLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PC14</accession>
    <name>A0AAN6PC14_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_40308</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854543">
        <property type="protein sequence ID" value="KAK4033242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PC14"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37535">
        <property type="entry name" value="FLUG DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37535:SF3">
        <property type="entry name" value="FLUG DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4033242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="255" mass="29299" checksum="F2C368E6D77665EB" modified="2024-10-02" version="1">MAYFIEGPLADELGLYWAGKTDKEGKKHKKAQQPILTIENYVRMQMQHWTRDGYQYRNEGNRVDNTNLLNNHCFTSARLSEVCQAVYDDLECILSWSGGEPEFRIKFKREECKGKDEKQPEHPFGEQIVGPDGVPPPLFAQPMLHWLANIISSRVFADYQTVEQALAARPPKNSGSYRVVPWAKAKENEPVFPKWTANGRGKKPRTPTSWANQAYDWARRANFVTQVFGMYAPRRAQLINVNNKYSLGEVLRFAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PCA7</accession>
    <name>A0AAN6PCA7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_18434</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854464">
        <property type="protein sequence ID" value="KAK4034835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PCA7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028000">
        <property type="entry name" value="Pma1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14610">
        <property type="entry name" value="Psg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042964573" evidence="3">
        <location>
            <begin position="23"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4034835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="371" mass="38834" checksum="8CAC81E59B79CD98" modified="2024-10-02" version="1">MRGTNPVRHLAVGATLLHHALALPQAGITVDPAPIAWVTVDASGSAQTITPSVITTEGHRATVSEAPSNLRSTTTYTLSTSGRPSTYTGLAPVASATGTGGSLAGVFPACDSNANVGAVEPFCLPKPGSELHPGMTYYITWSPTYFSPANLSVSLNVLYLDDEAGGGTTGFTSPPIPASAGFYAFPIPADFLTLHNNPSSQQQQKQDRYNITFLLAYPDDTSTANAPNDLITRVGPTVFITPLTPSLTTPTSPNITPIIVPIILVGAAAMLAVLCTLSWRKNGRARAVVGWAVGKMKMKRRSVEGGGYGQRQSRAERVGGGPWGGGGDDKSETDVGIQLTERDSWSPTGRREGGGGGNVFREEVERQARLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PDI7</accession>
    <name>A0AAN6PDI7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HCP-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_49507</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854499">
        <property type="protein sequence ID" value="KAK4034007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PDI7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010972">
        <property type="term" value="P:negative regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:001244">
        <property type="entry name" value="HCP-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052945">
        <property type="entry name" value="Mitotic_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43628">
        <property type="entry name" value="ACTIVATOR OF C KINASE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43628:SF1">
        <property type="entry name" value="CHITIN SYNTHASE REGULATORY FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4034007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="374" mass="40667" checksum="7402B9EE3C5E6778" modified="2024-10-02" version="1">MGLRDKFRKKHDSDDEASANPASPDGPEFTFIRTDTHSAEVIYPPSAGPHHDPGQFLSAEPKADSKQRRSLDVFRSGRSRSASTSSNHSSATRRLSQRLHLSRSPSSSENVPEDLPEIVVAEGAAEDKDGTESQWEKRATMLARENEKHRSRPSTPVHGSAPPVIPQLRLGDAPSNDSSDSQGKAVSSKVIDEDIQEAIRLHEAGQLQESTALFGRLADPKGANNPLSQVLYGLALRHGWGCQPDTAKAVTFLSAAASNAADVEHLALQAGLKKGGAAKGELVLAIFELANCFRHGWGIPKDPIAAKQYYETAANLGDTDAMNEVAWCYFEGFGTKKDKFAAAKYYRLAEKNGNKIIGNSWIWKDKYEPGHGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PDM7</accession>
    <name>A0AAN6PDM7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-actin-capping protein subunit alpha</fullName>
            <ecNumber evidence="3">1.2.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">C8A01DRAFT_49173</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + 3-methyl-2-oxobutanoate + H(+) = N(6)-[(R)-S(8)-2-methylpropanoyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:13457"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10497"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83142"/>
            <dbReference type="EC" id="1.2.4.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:13458"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the F-actin-capping protein alpha subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.4" evidence="3"/>
    <dbReference type="EMBL" id="MU854480">
        <property type="protein sequence ID" value="KAK4034416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PDM7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008290">
        <property type="term" value="C:F-actin capping protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003863">
        <property type="term" value="F:branched-chain 2-oxo acid dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009083">
        <property type="term" value="P:branched-chain amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006091">
        <property type="term" value="P:generation of precursor metabolites and energy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007584">
        <property type="term" value="P:response to nutrient"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07036">
        <property type="entry name" value="TPP_PYR_E1-PDHc-beta_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.210:FF:000003">
        <property type="entry name" value="F-actin-capping protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000001">
        <property type="entry name" value="Pyruvate dehydrogenase E1 beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000001">
        <property type="entry name" value="Pyruvate dehydrogenase E1 beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.60">
        <property type="entry name" value="F-actin capping protein, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.210">
        <property type="entry name" value="F-actin capping protein, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002189">
        <property type="entry name" value="CapZ_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037282">
        <property type="entry name" value="CapZ_alpha/beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042276">
        <property type="entry name" value="CapZ_alpha/beta_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042489">
        <property type="entry name" value="CapZ_alpha_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017865">
        <property type="entry name" value="F-actin_cap_asu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42980:SF1">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42980">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01267">
        <property type="entry name" value="F-actin_cap_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00191">
        <property type="entry name" value="FACTINCAPA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90096">
        <property type="entry name" value="Subunits of heterodimeric actin filament capping protein Capz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00748">
        <property type="entry name" value="F_ACTIN_CAPPING_A_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00749">
        <property type="entry name" value="F_ACTIN_CAPPING_A_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0117">Actin capping</keyword>
    <keyword evidence="7" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="10">
        <location>
            <begin position="79"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK4034416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="641" mass="69107" checksum="F97B0422CAFD5658" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PE60</accession>
    <name>A0AAN6PE60_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">LSM complex subunit LSm2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">C8A01DRAFT_47203</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854404">
        <property type="protein sequence ID" value="KAK4039302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PE60"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01725">
        <property type="entry name" value="LSm2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000009">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016654">
        <property type="entry name" value="U6_snRNA_Lsm2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13829">
        <property type="entry name" value="SNRNP CORE PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13829:SF2">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016394">
        <property type="entry name" value="U6_snRNA_Lsm2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="2"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR016394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK4039302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="98" mass="11168" checksum="1B9703AE4FACBC1B" modified="2024-10-02" version="1">MLFFSFFKTLIDHEVTVELKNDIQIRGVLKSVDQYLNIKLDNIQVLEEIKYPHMSAVKNVFIRGSVVRYVHLPANAVDVPLLEDATRREAANQAGKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PEB3</accession>
    <name>A0AAN6PEB3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_37583</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854428">
        <property type="protein sequence ID" value="KAK4038458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PEB3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4038458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="628" mass="68480" checksum="A1345F19445DEABA" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PEJ9</accession>
    <name>A0AAN6PEJ9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Metallothionein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_37429</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854424">
        <property type="protein sequence ID" value="KAK4038593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PEJ9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042948757" description="Metallothionein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4038593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="150" mass="15200" checksum="AEF242119423B122" modified="2024-10-02" version="1">MTTSTLALLSSLLVAGVQGAAPSASGDISWFDLARNATCTGHADGSISCQLRQVEAPDTAPHKAHLEPQGARPLDLDLEATVLESRAAQADDGKEEKVCSGEGPGKALGCFLNCFGQGSCNAKCDAANACQCSCKDGAGKGEVPCGKKSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PFY6</accession>
    <name>A0AAN6PFY6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">T-complex protein 1 subunit delta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">C8A01DRAFT_36773</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854405">
        <property type="protein sequence ID" value="KAK4039285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PFY6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03338">
        <property type="entry name" value="TCP1_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000010">
        <property type="entry name" value="T-complex protein 1 subunit delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012717">
        <property type="entry name" value="Chap_CCT_delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02342">
        <property type="entry name" value="chap_CCT_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK4039285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="535" mass="57055" checksum="20A91FBE3FDD3B3E" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PGE1</accession>
    <name>A0AAN6PGE1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATPase AAA-type core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_15915</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854383">
        <property type="protein sequence ID" value="KAK4040152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PGE1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054289">
        <property type="entry name" value="DUF7025"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411:SF2">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411">
        <property type="entry name" value="FAMILY ATPASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22942">
        <property type="entry name" value="DUF7025"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1031"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1058"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7025" evidence="4">
        <location>
            <begin position="177"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase AAA-type core" evidence="3">
        <location>
            <begin position="448"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="753"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="753"/>
            <end position="769"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4040152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1181" mass="132595" checksum="E3C3E5E4EDB1DD31" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PGI2</accession>
    <name>A0AAN6PGI2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein L15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_37965</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854439">
        <property type="protein sequence ID" value="KAK4038125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PGI2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1120.10:FF:000001">
        <property type="entry name" value="Ribosomal protein L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1120.10">
        <property type="entry name" value="Ribosomal protein l15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024794">
        <property type="entry name" value="Rbsml_eL15_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000439">
        <property type="entry name" value="Ribosomal_eL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020925">
        <property type="entry name" value="Ribosomal_eL15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003269">
        <property type="entry name" value="PRK04243.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11847:SF4">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11847">
        <property type="entry name" value="RIBOSOMAL PROTEIN L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00827">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01384">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01194">
        <property type="entry name" value="RIBOSOMAL_L15E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4038125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="203" mass="24110" checksum="AEDAA4C62BE4A274" modified="2024-10-02" version="1">MGALKYLEELSKKKQSDVVCFLLRVRCWELRQLNVIHRASRPSRPDKARRLGYKAKQGYVIYRVRVRRGGRKRPAPKGATYGKPTNQGINQLKYQRSLKSTAEERVGRRCANLRVLNSYWINQDSTYKYYEVILVDPQHKAIRRDPRINWIVNPVHKHRESRGLTATGKKSRGLNKGHRYNKTRAGRRKTWKRHNTLSLWRYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PH20</accession>
    <name>A0AAN6PH20_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Methyltransferase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_16909</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854411">
        <property type="protein sequence ID" value="KAK4039076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PH20"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF132">
        <property type="entry name" value="PROTEIN-LYSINE METHYLTRANSFERASE C42C1.13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4039076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="391" mass="42377" checksum="F0023BC5EFCE8F01" modified="2024-10-02" version="1">MHYIRFCRPPEVTAGPSQATVKVVLTITTDLSDAFLSPRSPVQLVVLGAYTEHKDGRDQLVPVNLTQGSPPTWRAGMRVLKLDLPLPPHPIETIQVRPLSQQLMAMGTSDVLPGNQGLIMAVYADMPRPGDGRAPAVCFRSLRLATGPVASGPTLQIEEDLGESIARHIWDSGIVMVSLLAEFCLDSTAEVGEEPLPLFRSILQAPSRPLNILELGCGVGVVGIGLARVMSFRQAGEASHILMTDLPEAEEKARANMARQAKILGNNSASLDFEPLDWEEGKNGRFGEKAASRPWDLVVLCDCTYNTDTLPPLVKTLSALHSHSAQHPSTAQGSVKTEVLVATKQRHSSERTFFDLMSGDGWVVREQTVLPLPLLDGEGQPVEVYLFGKQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PH60</accession>
    <name>A0AAN6PH60_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Archaemetzincin-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_35321</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854372">
        <property type="protein sequence ID" value="KAK4040667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PH60"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11375">
        <property type="entry name" value="Peptidase_M54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012962">
        <property type="entry name" value="Pept_M54_archaemetzincn"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15910">
        <property type="entry name" value="ARCHAEMETZINCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15910:SF1">
        <property type="entry name" value="ARCHAEMETZINCIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07998">
        <property type="entry name" value="Peptidase_M54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="19"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="292"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4040667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="449" mass="49469" checksum="A93B730E71AFA2CC" modified="2024-10-02" version="1">MPPCKHRALHLDVSPHAAEAGFARPSLAKRKAATTPSGRATGSTAEHARLESLFPGPLVLPDDGLAIDPKEPPQSLRSWATEKMRNPVTRRRKTIYVVPAPEIPQSPAFCPMLHKWKVPSVLPAPLKGGCDAPRADHVRDYLEAFYHPLPVKTLPGRAQFVPWTEGKSKPSPSQPPQYIGLQLGDGVTRITTRPCPDEVYPRQLSLNDVLDAAIEALPDDAYAMVVLTDHDLYEDDDDDFCCGRAYGSSRVAVVSSARYHPLLDEATGIDREHMWPFSHCDAYVQRLCKDAGGSTSGPTNRRKLTSPDPTSLGPEQPMQRVIQDGLAAPKPTDSHTGLWLSRMVRTVSHEVGHCVCLAHCSYYACVMQGTAGIAEDLRQPPYLCLVCEAKLARAVRDIGEADEVRWLVERYSLLVGFCAVWGRVSMFAAYRCWLQQRIAVLKGTLPVVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PH81</accession>
    <name>A0AAN6PH81_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ADP-ribosylglycohydrolase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_37541</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854427">
        <property type="protein sequence ID" value="KAK4038485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PH81"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4080.10">
        <property type="entry name" value="ADP-ribosylation/Crystallin J1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050792">
        <property type="entry name" value="ADP-ribosylglycohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005502">
        <property type="entry name" value="Ribosyl_crysJ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036705">
        <property type="entry name" value="Ribosyl_crysJ1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16222">
        <property type="entry name" value="ADP-RIBOSYLGLYCOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16222:SF28">
        <property type="entry name" value="ADP-RIBOSYLGLYCOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03747">
        <property type="entry name" value="ADP_ribosyl_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101478">
        <property type="entry name" value="ADP-ribosylglycohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="437"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="344"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="346"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605502-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4038485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="461" mass="50291" checksum="CB5B589D984FB6B5" modified="2024-10-02" version="1">MSTPTPTLPSSATTHLLRAALQDRIAGVLIGSALGDAIGLYTEFLTAANAAKAYPAGRFTLGGPSQCHPTPFKLDAHRAPKEPGDWTDDTDHALLLLLSFLHTARTSPNPNPTPDDGEEGGQHPPLPTQKDLAARLRVWVSQGFRPLDTMPLGLGRLVGTVVASQGFDADPESVAREYWERTGRRVAPNGSLMRTHPLGVICMFREEEEGLGVAAALSRVTHVDPRCVVACVIGTRLVRGVVRGEVVGEGDVDVVMGRAVEWFRGTGEELEEEELWRHVRCEGGLDELKLDDQAAIGYVYKTLGSGVMLLRMAIRRTATSRGGLLNRTRLFEDLITDLIMRGGDADTNACFAGALLGGYLGYSALPDHWKHGLKYQEWLLGKSDALCRVLGVMDGDYHGKEDKDTELQGGRPAVSQDEMEGRWMVLQQATFKKMEEVAKETSSKASRSGWSLPWQRAKGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PIA5</accession>
    <name>A0AAN6PIA5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">C-type lectin protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">C8A01DRAFT_34579</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="6">Amino-acid biosynthesis; ergothioneine biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854358">
        <property type="protein sequence ID" value="KAK4041381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PIA5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1580.10">
        <property type="entry name" value="paralog of FGE (formylglycine-generating enzyme)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024775">
        <property type="entry name" value="DinB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051128">
        <property type="entry name" value="EgtD_Methyltrsf_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019257">
        <property type="entry name" value="MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017805">
        <property type="entry name" value="SAM_MeTrfase_EasF-type_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005532">
        <property type="entry name" value="SUMF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042095">
        <property type="entry name" value="SUMF_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03439">
        <property type="entry name" value="methyl_EasF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43397">
        <property type="entry name" value="ERGOTHIONEINE BIOSYNTHESIS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43397:SF1">
        <property type="entry name" value="ERGOTHIONEINE BIOSYNTHESIS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12867">
        <property type="entry name" value="DinB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03781">
        <property type="entry name" value="FGE-sulfatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10017">
        <property type="entry name" value="Methyltransf_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine-specific methyltransferase SAM-dependent" evidence="9">
        <location>
            <begin position="54"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="DinB-like" evidence="10">
        <location>
            <begin position="394"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase-modifying factor enzyme-like" evidence="8">
        <location>
            <begin position="575"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase-modifying factor enzyme-like" evidence="8">
        <location>
            <begin position="784"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="645"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="754"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="768"/>
            <end position="788"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK4041381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="901" mass="100125" checksum="AEC3B37197A88743" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PID1</accession>
    <name>A0AAN6PID1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_34482</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854356">
        <property type="protein sequence ID" value="KAK4041529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PID1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018466">
        <property type="entry name" value="Kre9/Knh1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052982">
        <property type="entry name" value="SRP1/TIP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40633:SF1">
        <property type="entry name" value="GPI ANCHORED SERINE-THREONINE RICH PROTEIN (AFU_ORTHOLOGUE AFUA_1G03630)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40633">
        <property type="entry name" value="MATRIX PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05410)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10342">
        <property type="entry name" value="Kre9_KNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043027408" description="Fibronectin type-III domain-containing protein" evidence="4">
        <location>
            <begin position="23"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="173"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="58"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="102"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="113"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="151"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4041529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="311" mass="32056" checksum="9AEA88A67FBB74FA" modified="2024-10-02" version="1">MAKIAVWAILALALSLSGPVLAAVSFTNSEYYIHEGAPFTITWTGNQGPVGVNLMKGPDENLELVFVIVSASEAQEYTWTPPPTLPADSYILQLEDAGSTDYSPRFRYPVPLPSTTSTTGNSGPTPTPSTPTINPSSSTSTSPSTSPPPSTTETTTPPSTTGTAAAATLSTPAIAAIATLGGLLLLALIALCVYYTAYRRRKRGDILREEGGMGGMGNHEMSFGVSSPSGTTDTYMQSPGTVPGSAAGGGGVGYGGHGGYGGGTVHMKVAGGGENHGVGHRQQGQVYERAELPVRGWGEDVELSAEGRYLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PIN4</accession>
    <name>A0AAN6PIN4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_14717</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854355">
        <property type="protein sequence ID" value="KAK4041576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PIN4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4041576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="326" mass="34109" checksum="906C1D5963C6B24D" modified="2024-10-02" version="1">MSVVHNRRPPLATSVSAPDVFCRPMDPAPAPLVYINGWHGIGKETVAECLTLLLGKDKSLLIDVRSVGRETAPNNTCCGGGGSRVSKHKHHHRHEHNPLLTPEHPRYFSFDLDSDAYHFSPLPSPSSSPSFSSAFSPPTSRSASFSSDSTTATTISTSSTAPATTTTNLTALLTHPRNRARIAVLPACCPDTPAGHATLGIFEAAAARAGRLFVGVVLRCEEGVYLRRRRAEDGAAGGGGMGAGVCCAQGQSQSQDLGLARPVKAGLTVDVTCVPAFEAALQIVEFVKGLEAERDAELCSSGGSAATTPAQESERKLEPSGLAEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PIP7</accession>
    <name>A0AAN6PIP7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Diphthamide biosynthesis protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_16740</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DPH4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854405">
        <property type="protein sequence ID" value="KAK4039280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PIP7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.660.10">
        <property type="entry name" value="DPH Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007872">
        <property type="entry name" value="DPH_MB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036671">
        <property type="entry name" value="DPH_MB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037507">
        <property type="entry name" value="Ribosomal_mL59"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040922">
        <property type="entry name" value="Ribosomal_mL59_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28041">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L25, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28041:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18126">
        <property type="entry name" value="Mitoc_mL59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05207">
        <property type="entry name" value="Zn_ribbon_CSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144217">
        <property type="entry name" value="CSL zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51074">
        <property type="entry name" value="DPH_MB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="226"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="DPH-type MB" evidence="8">
        <location>
            <begin position="337"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="261"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4039280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="417" mass="46586" checksum="2354443C5FF2BD17" modified="2024-10-02" version="1">MAAAATKNIQLALALPARLRTFLARYPPASILPETHQKTAYQEETPNPFMPLKHPATGRWHDPKYSLRRQAELVKMARQHGVEELLPYTPKGTETRLRKRVELGLRVKGTGVGQKVKGHKHERQLGVKYVWVSNGRVWLGGGVMGVHTDLDVQQDGEEETGHVGYAGAHQGMEEEVKARDWLQILFSPKLSTSPQHHQLITTPTKFTREYHHPPPPTMPPTPQNPTYYEILNLSPSTLSSQEDANTSASLLKRAYHRALLTHHPDKTKSKNPSSTTPLQVEGKREPPKYTIDQISTAYATLSRPTQRQAYDRSLIVQSQQAAGGGIRGSGQAEFQTGIEAVDLDDLDYQEELDGTTTWYRSCRCGNPRGYHFTEADLADAGDVGELMVGCVDCSLWLRVYFAVLDEEDDDDSDDKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PJ24</accession>
    <name>A0AAN6PJ24_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tetratricopeptide repeat and J domain-containing co-chaperone DNJ1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">C8A01DRAFT_34968</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854365">
        <property type="protein sequence ID" value="KAK4041023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PJ24"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051787">
        <property type="term" value="F:misfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DnaJ and TPR domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000224">
        <property type="entry name" value="DnaJ and TPR domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051727">
        <property type="entry name" value="DnaJ_C3_Co-chaperones"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44140">
        <property type="entry name" value="LD25575P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44140:SF2">
        <property type="entry name" value="LD25575P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13431">
        <property type="entry name" value="TPR_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 7" id="KW-0802">TPR repeat</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042852422" description="Tetratricopeptide repeat and J domain-containing co-chaperone DNJ1" evidence="9">
        <location>
            <begin position="25"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="70"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="10">
        <location>
            <begin position="404"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="462"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="465"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00073740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK4041023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="519" mass="57401" checksum="C64C5D50EB58787E" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PJ99</accession>
    <name>A0AAN6PJ99_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Fungal-specific transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">C8A01DRAFT_45121</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854351">
        <property type="protein sequence ID" value="KAK4041792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PJ99"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15485">
        <property type="entry name" value="ZIP_Cat8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000007">
        <property type="entry name" value="C6 transcription factor FacB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF12">
        <property type="entry name" value="REGULATORY PROTEIN CAT8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="10">
        <location>
            <begin position="23"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="101"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="602"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="662"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="730"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="67"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="119"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK4041792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="892" mass="98388" checksum="8D28981341B1470A" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PJC6</accession>
    <name>A0AAN6PJC6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fucose-specific lectin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_45046</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the fungal fucose-specific lectin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854350">
        <property type="protein sequence ID" value="KAK4041837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PJC6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.70">
        <property type="entry name" value="Fucose-specific lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012475">
        <property type="entry name" value="Fungal_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07938">
        <property type="entry name" value="Fungal_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89372">
        <property type="entry name" value="Fucose-specific lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4041837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="297" mass="31849" checksum="442052C5AFE99303" modified="2024-10-02" version="1">MAAINDILIPTALAAVRKDAQLRVYQTAVDGGIREVQYEGQWMGGEPRNVIATGKIGTPVAATNIGFQHIRVYYVTPDNHLGEAAYDSGTGWYDGSLSSMNFAVAPYSSVAAIFLGGQTVLRVYGQLHDNTIQEWVYGGGSGWTVGSNLGPALPGTQIAATTWGNDPYHLRVYAQNADLNVFEKTWDGQGWNTGALSFPNQVPRAALGVTSWGEGSSLGIRLYYGAPGNVIKEKAWDGSGGWYDGNFEEACIPASNVAALPLDILRVYLQNGTEDSAVTEYMWSSGWRVGYAALPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PJM7</accession>
    <name>A0AAN6PJM7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein uL11m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">C8A01DRAFT_35758</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the universal ribosomal protein uL11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854381">
        <property type="protein sequence ID" value="KAK4040244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PJM7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00349">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.250:FF:000005">
        <property type="entry name" value="Mitochondrial 54S ribosomal protein YmL19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1550.10:FF:000004">
        <property type="entry name" value="Mitochondrial 54S ribosomal protein YmL19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.250">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1550.10">
        <property type="entry name" value="Ribosomal protein L11/L12, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00736">
        <property type="entry name" value="Ribosomal_uL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000911">
        <property type="entry name" value="Ribosomal_uL11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006519">
        <property type="entry name" value="Ribosomal_uL11_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020783">
        <property type="entry name" value="Ribosomal_uL11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036769">
        <property type="entry name" value="Ribosomal_uL11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020784">
        <property type="entry name" value="Ribosomal_uL11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036796">
        <property type="entry name" value="Ribosomal_uL11_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01632">
        <property type="entry name" value="L11_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL11M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00298">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03946">
        <property type="entry name" value="Ribosomal_L11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00649">
        <property type="entry name" value="RL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54747">
        <property type="entry name" value="Ribosomal L11/L12e N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46906">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8 11" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL11 N-terminal" evidence="10">
        <location>
            <begin position="15"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL11 C-terminal" evidence="9">
        <location>
            <begin position="78"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK4040244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="157" mass="16708" checksum="FE77F27CE637C28D" modified="2024-10-02" version="1">MSKARSAVGGMDQVVKIIVGAGQASPSPPVGPALGSKGIKSMDFCKEFNARTQHMVAGTPMPVRVTVRPDRTFHFEVRTPQTSWLLLNAAEVPAGKKGKRKGASNPGKETVGSVSLKHVYEIAKIKQSELRLSGLSLEGLCRSIIYQARSIGLAVVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PKA4</accession>
    <name>A0AAN6PKA4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">xylan 1,4-beta-xylosidase</fullName>
            <ecNumber evidence="13">3.2.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">C8A01DRAFT_15537</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Hydrolysis of (1-&gt;4)-beta-D-xylans, to remove successive D-xylose residues from the non-reducing termini.</text>
            <dbReference type="EC" id="3.2.1.37"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan degradation; xylan degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.37" evidence="13"/>
    <dbReference type="EMBL" id="MU854373">
        <property type="protein sequence ID" value="KAK4040589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PKA4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009044">
        <property type="term" value="F:xylan 1,4-beta-xylosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031222">
        <property type="term" value="P:arabinan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1700:FF:000007">
        <property type="entry name" value="Exo-1,4-beta-xylosidase xlnD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000013">
        <property type="entry name" value="Probable exo-1,4-beta-xylosidase xlnD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044993">
        <property type="entry name" value="BXL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42721:SF3">
        <property type="entry name" value="BETA-D-XYLOSIDASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42721">
        <property type="entry name" value="SUGAR HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 14" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042921605" description="xylan 1,4-beta-xylosidase" evidence="14">
        <location>
            <begin position="18"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type III-like" evidence="15">
        <location>
            <begin position="690"/>
            <end position="761"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00026107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK4040589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="785" mass="84736" checksum="BFBABEBC9A93C871" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PKJ3</accession>
    <name>A0AAN6PKJ3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">tRNA (uracil-O(2)-)-methyltransferase</fullName>
            <ecNumber evidence="3 11">2.1.1.211</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">C8A01DRAFT_35283</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-methyltransferase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>uridine(44) in tRNA(Ser) + S-adenosyl-L-methionine = 2'-O-methyluridine(44) in tRNA(Ser) + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43100"/>
            <dbReference type="Rhea" id="RHEA-COMP:10339"/>
            <dbReference type="Rhea" id="RHEA-COMP:10340"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74478"/>
            <dbReference type="EC" id="2.1.1.211"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the TRM44 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.211" evidence="3 11"/>
    <dbReference type="EMBL" id="MU854371">
        <property type="protein sequence ID" value="KAK4040724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PKJ3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141101">
        <property type="term" value="F:tRNA(Ser) (uridine(44)-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011671">
        <property type="entry name" value="tRNA_uracil_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21210">
        <property type="entry name" value="TRNA (URACIL-O(2)-)-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21210:SF0">
        <property type="entry name" value="TRNA (URACIL-O(2)-)-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07757">
        <property type="entry name" value="AdoMet_MTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="7 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 11" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK4040724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="507" mass="56089" checksum="8AD903AB62424D8A" modified="2024-10-02" version="1">MGFEPEELAVDTSPAVVVEAATCHGDKENWRPLFRHACAFGPDVFGDVLVNLIQNPNINSSWLFRADILHDSAEPQACAPSEATDTSGIPSPSFVGFELRRSIIRRLIPRNTLRDKPLDQTCLIYESAPSPEGDEAAAEKSLVVYLPHVSTASEMPFYHPIVRGIAFLHEWTAAESRGSISISYLFFDEEDRSVVRLTRTALRLLEVIHKHGKGRLAGYQKRVHHDQLLPQARVQNTYTRLKQKYARGLIESWAETTDPEKHVFEDLCIAAFLVELWADMYGQAPFSGFVDIGCGNGLLVYILNQEGFAGWGFDARLRKSWATYNTKLQTAAGEEDTLKELVLLPPPVSRDGLASLSSDGFNEDRIHDGRFPKGTFIISNHADELTPWTPIIAAISECPFIAIPCCSHNLAGERYRAPAPKDKTKADSAYSSLVAWVSDISRDCGWEVEQEMLRIPSTRNTALIGRKQSTPTSSLDIQAIVNQYGGTAGYLESVIKLVASTASGSEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PKV7</accession>
    <name>A0AAN6PKV7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_44467</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854339">
        <property type="protein sequence ID" value="KAK4042582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PKV7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046921">
        <property type="term" value="F:alpha-(1-&gt;6)-fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13132">
        <property type="entry name" value="ALPHA- 1,6 -FUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13132:SF29">
        <property type="entry name" value="ALPHA-(1,6)-FUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4042582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="633" mass="68824" checksum="BC32B93359002CA0" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PL22</accession>
    <name>A0AAN6PL22_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_15668</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854376">
        <property type="protein sequence ID" value="KAK4040480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PL22"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF2">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="31"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4040480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="259" mass="29585" checksum="962C8AB9BC15C1D4" modified="2024-10-02" version="1">MPADSQSTQSVRPTGTQGSSQELQGLDSWLTDRIVTVTVGPEEKRWVVHEKLLISQSEFFSNHFLLGSDEMKLPDDDPRLFALFIRWLYGTAFLPSGGARNFRFLPPDGTTLTVRDYLGVYIMGGKFGIVGVRNAVLDVLYAYYGEASDDHQSPDMRDITYVFDHTGPDAPMRRFLIAHALFFLFSKNRRGAPLPPDWAQVLNEYSEVGYDMIRMMGEWNWVMGSNAPRMAIKPRVEFHERVPRPQVVKQEEVEEDTQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PL34</accession>
    <name>A0AAN6PL34_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ubiquitin 3 binding protein But2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_32812</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854332">
        <property type="protein sequence ID" value="KAK4043023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PL34"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042975788" description="Ubiquitin 3 binding protein But2 C-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4043023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="182" mass="19639" checksum="74C02BE6C1E67F42" modified="2024-10-02" version="1">MHLSLTTFLLISLTSLTSLTTALPTTTPFNLNLLTPKTTCTRLRPPSTPRLNLLNRPDLSLTTTQTLTFTLPPSAPGPCTLRAVFPPHWEIIDTRLQSGGEPLSVNVYAIDGPAAGALVGSVRFADKDRKEWAERVVVVNSFACRERMAYRFELAGVGEVGFVNGFDAGLGVEGGVEMVYGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PL67</accession>
    <name>A0AAN6PL67_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_44851</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854346">
        <property type="protein sequence ID" value="KAK4042075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PL67"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="4">
        <location>
            <begin position="191"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="195"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="209"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4042075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="368" mass="40137" checksum="BE807134DC946ADC" modified="2024-10-02" version="1">MPSPSDDIPPFPDNLPLAPIAIISHAKLLNGDQDEAARVLEAAKTDGFFDLNLQDTRQGEALLAESEQLRALAKDAFAAPLHEKLHYALERGVSLFGYKPAGTVKTTDRDQRPDTTEFFNISKDYLHNTPTPSRGTKPLTYPPQIENHRPLLQSFTRHGHACGMLILRTLASQLGLPPDEFTNLNLFDHPSGDHCRLTHKTPPPPPNPEAAAATTTGPAGNPPIGLPSHTDFGSVTILFNWLGGLQIESHGHQASREREWEWVKPLPSHAIVNLGDAMATFTNGVLKSAKHRVVPSPAATHRYSVVYFVRPHNDVPMKPLAQFANRDRDHAGAAAQQVAGKFSATLGPGQEVLAAGEWMRQRAVQLGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PL88</accession>
    <name>A0AAN6PL88_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">Vacuolar protein sorting-associated protein 27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">C8A01DRAFT_13332</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB) and recruits ESCRT-I to the MVB outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 12">Component of the ESCRT-0 complex composed of HSE1 and VPS27.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Endosome membrane</location>
            <topology evidence="2 12">Peripheral membrane protein</topology>
            <orientation evidence="2 12">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the VPS27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854331">
        <property type="protein sequence ID" value="KAK4043104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PL88"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033565">
        <property type="term" value="C:ESCRT-0 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15735">
        <property type="entry name" value="FYVE_spVPS27p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21385">
        <property type="entry name" value="GAT_Vps27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16979">
        <property type="entry name" value="VHS_Vps27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1940:FF:000001">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000031">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000161">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017073">
        <property type="entry name" value="HGS/VPS27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049425">
        <property type="entry name" value="Vps27_GAT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47794">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47794:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02809">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21356">
        <property type="entry name" value="Vps27_GAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036956">
        <property type="entry name" value="Hrs_Vps27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0967">Endosome</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="VHS" evidence="16">
        <location>
            <begin position="26"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="15">
        <location>
            <begin position="168"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="230"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="287"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="460"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="230"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="295"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="530"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="590"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="606"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="643"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="672"/>
            <end position="683"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR036956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAK4043104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="723" mass="78608" checksum="4FAD87517DC34AB2" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PLB3</accession>
    <name>A0AAN6PLB3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_15549</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854373">
        <property type="protein sequence ID" value="KAK4040615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PLB3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35711:SF1">
        <property type="entry name" value="ECTODERMAL, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35711">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="436"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4040615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="604" mass="66504" checksum="3A272E49A22D19CA" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PLR3</accession>
    <name>A0AAN6PLR3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_45934</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854369">
        <property type="protein sequence ID" value="KAK4040825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PLR3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF37">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4040825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="473" mass="54187" checksum="D11946385568C187" modified="2024-10-02" version="1">MPATLEVPGRGPITTYESAIEEEFNVISRLAHAPAVKALADDLWRQRASIEALTRQHLGLGKHDTCNILERQQWIRGGLNICVLLHVESSGQQRKVVFCCAMPHKLAEAQYAGTVDEKLSCEIGAYLWMQENCPDVRIPCLYGFGFSDGRYFTHARYRPFLSRISRIVASAYMLLEYVNPVSGQMLSATQRLFSGISKIMLSLARLPQPRIGPFQFHDDGTVSLTNRPLSCSMVLIENDGAPRTMQQIDIYRCTDGFVSDMLTFHDHRFLSQPNAVYSEGDCRGQMAVKTLLRALSHRYIKREHRHGPFLLQLTDLHASNIFVDDDWNITCLIDLEWLCALPPEMLNVPYWLTGCSIDEIQDECYDEFDEVQQEFMSVFQEKEGQTRAEHQISLSKVMQDIWDSKGIWFWYCLSSVNAMYFLIESHLCPPGSLSTNVERAVSQFWRHDSETVVQMKLADRKDYDGELRRVFGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PLS5</accession>
    <name>A0AAN6PLS5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_35115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854368">
        <property type="protein sequence ID" value="KAK4040840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PLS5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042838283" evidence="1">
        <location>
            <begin position="21"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4040840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="118" mass="12863" checksum="30F05EB087F748E6" modified="2024-10-02" version="1">MRFTLPSLVLVSGLAQVGTATWIVDFYEKGCPKDGDTTNLDSVGSTSGQKGDEMWCYPVDSAHSGVLRGIEADGYKVDLFTDWLCHPQYLIETWTTDGCFVVNSEPNTVIAGARIVPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PLV1</accession>
    <name>A0AAN6PLV1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_13131</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854328">
        <property type="protein sequence ID" value="KAK4043331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PLV1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050167">
        <property type="entry name" value="Ser_Thr_protein_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23257:SF963">
        <property type="entry name" value="AT08303P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23257">
        <property type="entry name" value="SERINE-THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="219"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="515"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="562"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="564"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="594"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="673"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="705"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="741"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="763"/>
            <end position="772"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4043331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="844" mass="95022" checksum="D80F386C2ED1DFFE" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PMH5</accession>
    <name>A0AAN6PMH5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-histidine N-methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.85</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">C8A01DRAFT_43445</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the methyltransferase superfamily. METTL18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.85" evidence="3"/>
    <dbReference type="EMBL" id="MU854325">
        <property type="protein sequence ID" value="KAK4043691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PMH5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018064">
        <property type="term" value="F:protein-L-histidine N-tele-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF39">
        <property type="entry name" value="HISTIDINE PROTEIN METHYLTRANSFERASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="19"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK4043691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="368" mass="40178" checksum="578D7F233858704B" modified="2024-10-02" version="1">MAFSFSFAGDDIEEDHQAPAPPPPTGSTASAPPPPTAGAFPVQGKPLLRPTQHDLEALLSRLPSKIAFSVLDVDLGDGRVLQLPRRELWDVRVQLMAEDSTDSPSESEAGLGEHDVKTGIYEGGFKSWESSVDLVKVLARERATDLLKQDPCVLIELGCGTALPSLALFQWALTERKSEQKQPLVLTLADYNPTVLYLVTLPNLVLAWALQQRKENAVVEEAFTPDEELELTPEVLDAFRQSLSANRITLSFLSGAWSPEFVDLLYHSGVPVSHPDNTKTLLLGSETIYSPFALESFGSTLLSILQRERLERPGGEARALIAAKRLYFGVGGSLDDFVDKMRGLGASVRTLFEETQGVHRGVVECLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PMU9</accession>
    <name>A0AAN6PMU9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">WSC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_14571</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854352">
        <property type="protein sequence ID" value="KAK4041746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PMU9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051836">
        <property type="entry name" value="Kremen_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24269">
        <property type="entry name" value="KREMEN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24269:SF16">
        <property type="entry name" value="PROTEIN SLG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043021174" evidence="7">
        <location>
            <begin position="24"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="8">
        <location>
            <begin position="39"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4041746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="386" mass="40908" checksum="FFBCA8BFB158EFF2" modified="2024-10-02" version="1">MRLRVGQALAAAAGLLGVVDVQAFFGSVSAEISSCGSDNFINLGCFNNFLLNAGIFFNFNPQGPNPADPSRSFPDWVPGSLLNSTVTPLNCARVCRGYGYKFAALRDNSCTCGIQLPTGYEPSAAAVCNVPCNGDRTQTCGGGADAQIYADPTFAANELVPIGNSNPTIADYYKYLGCYNAPGGFPTSDARASALVADIDVCFNLCAGLGYLLVHGAPEAGQVRCLCGTTFGLGAFRVHPEFLPTPGVCNTTCNAGAGVFGDCDISSQRCCGQNNIFPVYINTELQGCYTPLIPGYKRLLTDPFYECDDIPDTLTGPPTVLDQPGYDPGLIITGTAALIRRRTVPVPGSNTFYIYGSLASSLQTLSPLRASHFPFPFHQFHHFSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PNY3</accession>
    <name>A0AAN6PNY3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_42919</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MSOX/MTOX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854320">
        <property type="protein sequence ID" value="KAK4044247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PNY3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050031">
        <property type="term" value="F:L-pipecolate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004657">
        <property type="term" value="F:proline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008115">
        <property type="term" value="F:sarcosine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045170">
        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961:SF46">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="6">
        <location>
            <begin position="23"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4044247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="497" mass="51950" checksum="FFAE1E0F187BC158" modified="2024-10-02" version="1">MAAAAASSSLPPSSQPFSPPSSILIIGSGVLGLSTALALARRDAFSRCSITVVDRSDPSQPGAFPSPDAASIDASRVIRADYADPAYTALGDEAQAQWRKQDKPTDLGAQGRYHETGLLLVGDATPPAPAAAPAGEGLKPKLTGVDYARMSWANVLSLASKAPDLAARVRELPNREAIRDALGTGGSSGSWGYANYNSGWANAATSMAWLLDQVQQTGRVNFVPGTVVSLERNGDAVTGATLSDGRVLSADLIVVAAGAWTGGLVDLAGQAVATGQVMAYLDITEAEQEKLANIPVILNLSTGLFIIPPTDRVLKVARHAYGYINPVTLANPPLPLSPNSPPTPEVSLPRTTLTHPSLTIPGSAATDLRRALREMIPWPALHDRPFSKTRLCWYSDTPNADFLIDYHPHWRGLFVATGDSGHAFKFLPVIGDKVADCIMRDCPAAFRGKWEWKVTAGSGSGAAAAAVFTEDGSRGGTPGIVLADALVEGEGVVSASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PPK6</accession>
    <name>A0AAN6PPK6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Adenylyl-sulfate kinase</fullName>
            <ecNumber evidence="3">2.7.1.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP adenosine-5'-phosphosulfate 3'-phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Adenosine-5'-phosphosulfate kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">C8A01DRAFT_12082</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the APS kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.25" evidence="3"/>
    <dbReference type="EMBL" id="MU854318">
        <property type="protein sequence ID" value="KAK4044592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PPK6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004020">
        <property type="term" value="F:adenylylsulfate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019344">
        <property type="term" value="P:cysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02027">
        <property type="entry name" value="APSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000212">
        <property type="entry name" value="Adenylyl-sulfate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00065">
        <property type="entry name" value="Adenylyl_sulf_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002891">
        <property type="entry name" value="APS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059117">
        <property type="entry name" value="APS_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052061">
        <property type="entry name" value="PTE-AB_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00455">
        <property type="entry name" value="apsK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003013">
        <property type="entry name" value="PRK03846.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260:SF7">
        <property type="entry name" value="THIOESTERASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G10800)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260">
        <property type="entry name" value="UPF0644 PROTEIN PB2B4.06"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01583">
        <property type="entry name" value="APS_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="7 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042852743" description="Adenylyl-sulfate kinase" evidence="12">
        <location>
            <begin position="25"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="Thioesterase" evidence="14">
        <location>
            <begin position="192"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="APS kinase" evidence="13">
        <location>
            <begin position="321"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK4044592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="509" mass="55573" checksum="A4BC937E572A19B2" modified="2024-10-02" version="1">MSSRLFSAARRLPCALLLATPARSAQLPYAQFITTAAGKPGLLGCRPGTAPSRAEKIAFHRRAASVAGRIFLFTTLGFIMAAAPAYESAAAILSPPSDADTLDLFTPQGDDAKAKEAYINSHPLAAALRAEPDFIESRPHMKIPPSWRRHNLTGGTLAGPGKMAIPPFSWTQRDGKSYVQITHVGTDLCGHMGIIHGGFLATMLDEGLARCCFPVLPFNVGMTAKLEINYKAPAMADQYLVLRATTVKVEGRKAWVEGHIETLPAEQGQEPTVLATASALYISPKQASVRVPNPRPNRDSSNITWHPSLTRHERNQLRGQRGFTVWFTGLSASGKSTVATALEQHLLHIGVAAYRLDGDNVRFGLNKDLGFSEKDRNENIRRIAEVAKLFADASTIALTSFISPYRADRQIARDLHASASQANDDPLPFIEVFVDVPLEEAEKRDPKGLYKKARAGEIKDFTGISAPYEAPEAPEITIRTDLLSVEECVRKIVEYLAEKGLINQTQETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PQI6</accession>
    <name>A0AAN6PQI6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tyrosinase</fullName>
            <ecNumber evidence="3">1.14.18.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">C8A01DRAFT_42795</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>2 L-dopa + O2 = 2 L-dopaquinone + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:34287"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57504"/>
            <dbReference type="ChEBI" id="CHEBI:57924"/>
            <dbReference type="EC" id="1.14.18.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-tyrosine + O2 = L-dopaquinone + H2O</text>
            <dbReference type="Rhea" id="RHEA:18117"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57924"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="EC" id="1.14.18.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tyrosinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.18.1" evidence="3"/>
    <dbReference type="EMBL" id="MU854319">
        <property type="protein sequence ID" value="KAK4044355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PQI6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004503">
        <property type="term" value="F:tyrosinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042438">
        <property type="term" value="P:melanin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016216">
        <property type="entry name" value="Monophenol_mOase_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041640">
        <property type="entry name" value="Tyrosinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF76">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18132">
        <property type="entry name" value="Tyrosinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000340">
        <property type="entry name" value="MPO_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00497">
        <property type="entry name" value="TYROSINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0186">Copper</keyword>
    <keyword evidence="8" id="KW-0470">Melanin biosynthesis</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="11">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="12">
        <location>
            <begin position="295"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK4044355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="666" mass="72779" checksum="204903F16128892D" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PR26</accession>
    <name>A0AAN6PR26_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">ATP-dependent DNA helicase PIF1</fullName>
            <ecNumber evidence="15">5.6.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">DNA 5'-3' helicase PIF1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">DNA repair and recombination helicase PIF1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">PIF1</name>
        <name evidence="18" type="ORF">C8A01DRAFT_12026</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="15">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the helicase family. PIF1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="15"/>
    <dbReference type="EMBL" id="MU854317">
        <property type="protein sequence ID" value="KAK4044670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PR26"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18037">
        <property type="entry name" value="DEXSc_Pif1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18809">
        <property type="entry name" value="SF1_C_RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001226">
        <property type="entry name" value="ATP-dependent DNA helicase PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03176">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049163">
        <property type="entry name" value="Pif1-like_2B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048293">
        <property type="entry name" value="PIF1_RRM3_pfh1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642:SF5">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21530">
        <property type="entry name" value="Pif1_2B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 15" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 15 18" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 15" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9 15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="17">
        <location>
            <begin position="321"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="DNA-binding region" evidence="15">
        <location>
            <begin position="678"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="96"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="152"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="737"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="114"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="176"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="219"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="752"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="329"/>
            <end position="336"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAK4044670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="764" mass="82698" checksum="5C83DA16F9C19044" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PRC0</accession>
    <name>A0AAN6PRC0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_42727</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854318">
        <property type="protein sequence ID" value="KAK4044548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PRC0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43991:SF12">
        <property type="entry name" value="WD REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_8G05640)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43991">
        <property type="entry name" value="WD REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_8G05640)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="544"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="54"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4044548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="736" mass="80810" checksum="E99B41D37F6FDA68" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PRC2</accession>
    <name>A0AAN6PRC2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_32274</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854326">
        <property type="protein sequence ID" value="KAK4043546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PRC2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="93"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4043546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="263" mass="28826" checksum="27F93633A3B0658E" modified="2024-10-02" version="1">MFAFFRRLLSLRIPGLDLQATETSFTVTLRNIQLFRTEIPTIVRAARLPGQARDTMRTTVHRVRHVITRVTRVTQTTQQDQQQRRQIITLSPAAWCVLITLDVFLLPLALAGLFILFWLAVIWLILYLTYETADCIAFNAAHMLDGPVETSLKLIWGLARSGQMFLLANTMAVNRQANTPVTGGAEGSTSMAVTGGAVGSTSMAVTGPTAGSTSTAVAGPVAGQDRESEEVILYEGRAQDERQLPEPGFLSTPPATRRRRGDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PRS1</accession>
    <name>A0AAN6PRS1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Exonuclease V</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_12382</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EXO5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854321">
        <property type="protein sequence ID" value="KAK4044099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PRS1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045145">
        <property type="term" value="F:single-stranded DNA 5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019190">
        <property type="entry name" value="EXOV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14464">
        <property type="entry name" value="EXONUCLEASE V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14464:SF4">
        <property type="entry name" value="EXONUCLEASE V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09810">
        <property type="entry name" value="Exo5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6 8" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="33"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="150"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="429"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="505"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="637"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="85"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="176"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="430"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="449"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="535"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="646"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="661"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="716"/>
            <end position="728"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4044099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="728" mass="79984" checksum="69B7FB4AC36E69B7" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PSW1</accession>
    <name>A0AAN6PSW1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_31833</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854322">
        <property type="protein sequence ID" value="KAK4043960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PSW1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4043960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="154" mass="16725" checksum="5D96ACB190B8E6AE" modified="2024-10-02" version="1">MAGNGLDPNQVTALQKRFSGLDDQLHYQKGHTIYNKYATYKAADKAAGTASTAYKGEAAKLKATKPYDPNQKRGNVGGTTYYQAGHRTLAPLAGTASQTAQYHYERRDSFNVKYKDVLTAQGPKVYQNHVEAAGSAQASATKYAGLQQKHQAHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SLD5</accession>
    <name>A0AAN6SLD5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tripeptidyl-peptidase II</fullName>
            <ecNumber evidence="4">3.4.14.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">C8A01DRAFT_41934</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Secreted tripeptidyl-peptidase which degrades proteins at acidic pHs and is involved in virulence.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal tripeptide from a polypeptide.</text>
            <dbReference type="EC" id="3.4.14.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="15">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
            <location evidence="3">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.14.10" evidence="4"/>
    <dbReference type="EMBL" id="MU854746">
        <property type="protein sequence ID" value="KAK4031618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SLD5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008240">
        <property type="term" value="F:tripeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04056">
        <property type="entry name" value="Peptidases_S53"/>
        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Tripeptidyl-peptidase_I"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51695">
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    </dbReference>
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        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="11 15" id="KW-0106">Calcium</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="10 15" id="KW-0720">Serine protease</keyword>
    <keyword evidence="8 17" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0843">Virulence</keyword>
    <keyword evidence="13" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042834383" description="tripeptidyl-peptidase II" evidence="17">
        <location>
            <begin position="19"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S53" evidence="18">
        <location>
            <begin position="238"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="175"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
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            <begin position="178"/>
            <end position="189"/>
        </location>
    </feature>
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        <location>
            <position position="317"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="321"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="541"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="584"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="585"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="609"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="611"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001910"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00002451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012462"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022525"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAK4031618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="630" mass="67832" checksum="A949F948C82EA1BD" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SLJ5</accession>
    <name>A0AAN6SLJ5_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">C8A01DRAFT_40716</name>
    </gene>
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        <name type="scientific">Parachaetomium inaequale</name>
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            <taxon>Ascomycota</taxon>
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            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="243"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4032831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="266" mass="28499" checksum="C8900058F2D9FAF1" modified="2024-10-02" version="1">MSSSPHRPVSAGSDKSRKSAGSDNSHKTANSTGSGNSALSSVTVKSFHSALSDDSYIGDLAQRNIDNALKEMLTEVKLLDGSNTLVMARKLLSHDVKKLDPADIQKRKWSEQMVKDHSAYKDKVKALEVARKVALASTKAAKKASRGNNVNFVKLEQLRHKALDDDEVWLNAAIGASSARMGFMNKYPDAFNTESAKKHVKAAQDNIDSVKNALRETGEQRKKITELKPLEAVKTAQAATAARTAVTAATGAASNAGASQPANKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SLY4</accession>
    <name>A0AAN6SLY4_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">C8A01DRAFT_41370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
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            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854637">
        <property type="protein sequence ID" value="KAK4032188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SLY4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4032188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="129" mass="14213" checksum="FF41F646B182FD53" modified="2024-10-02" version="1">MSEDKDALDTAQVHAAVERIAYERARGGPSTVHAARMSRIVGYPVVAMRRKDLAADLVEKVLADWEGRRSEKRVRLWWAQRGAPADGGCAHAPLHGQEGRDYLWAVDVAATFYLLGVALPVALPAIRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SMA8</accession>
    <name>A0AAN6SMA8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_39889</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854517">
        <property type="protein sequence ID" value="KAK4033656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SMA8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4033656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="374" mass="41809" checksum="2BE98ECE0ED7BFE5" modified="2024-10-02" version="1">MAPNSRPPSLPSIPDISLDLDEKTHLLPELEEALSSAGETSTTFDDDNDFRPSRSHSTHTQNSFHHRRIVLPSRFPSTSSSAPTTYTTTTLPLSPRRYDLTYQVQPLQLPPTQKTIHESWTITYHHPTPRTKIHIRALGITLFRHFGRDEGSILSVVPNTHFSQEELASTVALHEASVAAHSQRHHQKRTTLCKPKIAGTPTPCTGATGGSGSAGGGSWDSAVYAADVEKRIRGLEWKVQDEIYELLSDRVQSSSNAFRRREWRVVVLTEVPGGELTDSPTGFRRFGAGPGAGGRGWFGFGKSRRLGVKATRWPDMPITEYRLVLRGAETKANDQGWGYYNRYSRPWRAADEKEIGEKKRWSSLTGKSEKYVDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SMK1</accession>
    <name>A0AAN6SMK1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_20296</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854587">
        <property type="protein sequence ID" value="KAK4032655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012943">
        <property type="entry name" value="Cnn_1N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019528">
        <property type="entry name" value="PACT_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43941">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43941:SF11">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07989">
        <property type="entry name" value="Cnn_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10495">
        <property type="entry name" value="PACT_coil_coil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Centrosomin N-terminal motif 1" evidence="8">
        <location>
            <begin position="176"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Pericentrin/AKAP-450 centrosomal targeting" evidence="9">
        <location>
            <begin position="1274"/>
            <end position="1398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="50"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="450"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1427"/>
            <end position="1469"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="1002"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="1054"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1437"/>
            <end position="1447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1460"/>
            <end position="1469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4032655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1469" mass="168726" checksum="0CA3C7715FAD7428" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SMK9</accession>
    <name>A0AAN6SMK9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_20116</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854568">
        <property type="protein sequence ID" value="KAK4032877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SMK9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4032877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="100" mass="11730" checksum="43E328348B26C6B1" modified="2024-10-02" version="1">MAHPIIVIASFLTTIKSTWELSRMVRKKRAAKTLTTEAKSTYVLLKQAYGKRLLLEREFDYLFERLMRAEAHNDVVALRKVRADFQAILRKAQQPARRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SMR8</accession>
    <name>A0AAN6SMR8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glucanase</fullName>
            <ecNumber evidence="9">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">C8A01DRAFT_40175</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 7 (cellulase C) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="9"/>
    <dbReference type="EMBL" id="MU854534">
        <property type="protein sequence ID" value="KAK4033389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SMR8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07999">
        <property type="entry name" value="GH7_CBH_EG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.100.10">
        <property type="entry name" value="Glycoside hydrolase, family 7, domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001722">
        <property type="entry name" value="Glyco_hydro_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037019">
        <property type="entry name" value="Glyco_hydro_7_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33753">
        <property type="entry name" value="1,4-BETA-D-GLUCAN CELLOBIOHYDROLASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33753:SF1">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE CELB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00840">
        <property type="entry name" value="Glyco_hydro_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00734">
        <property type="entry name" value="GLHYDRLASE7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 9" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042917196" description="Glucanase" evidence="10">
        <location>
            <begin position="21"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK4033389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="430" mass="46397" checksum="6B38AEB7DB1644C0" modified="2024-10-02" version="1">MARSAAFLGLASLLLGAANGQLPGEGKEVHPKITTYRCSKAGGCKEETNYIVLDALAHPVHQATNPSNCGNWGEPANATACPDQESCAKNCIMDPVADYSKYGIQTDGSALRLQQLLDGKLVSPRVYLLDKTERRYEMLSLTGNEFTFDVDATKLPCGMNSALYLSEMHPTGAQSKLNPGGAYMGTGYCDAQCFVTPFINGLGNIDGKGACCNEMDIWEANARANSVAPHPCNVKGPFLCEGADCEDDGVCDKSGCVWNPYRVNVTDYYGITDQFKVDSSRPFTVVTQFPANRKGKLEAIHRLYVQDGRVVESYTVDAPGLPKTDSLTDEFCKATGPAKYMDLGGTQGMGEALTRGMVLALSIWWDEGGNMNWLDAGESGPCNLEEGNPSNIVKVEPSPEVTFSKMRWGEIGSTYESGENGKGKCKSKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SMW2</accession>
    <name>A0AAN6SMW2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable enoyl-CoA hydratase, mitochondrial</fullName>
            <ecNumber evidence="2">4.2.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_50174</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.17" evidence="2"/>
    <dbReference type="EMBL" id="MU854546">
        <property type="protein sequence ID" value="KAK4033192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SMW2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000019">
        <property type="entry name" value="Enoyl-CoA hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.12.10:FF:000001">
        <property type="entry name" value="Probable enoyl-CoA hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF54">
        <property type="entry name" value="ENOYL-COA HYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00073937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4033192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="298" mass="31878" checksum="19FBA80530F3A357" modified="2024-10-02" version="1">MNAAAARANALGTMRPLASRFQPRTLPQIARSFSASARRSYEYIEVSEPRPGVGQITLNRPKALNALCTPLITELNTALHTFQTTPTIAAIILTGSARAFAAGADIKEMAPLSFSTAYTTAFIESWSDLTTSLKKPLIAAVSGHALGGGCELALMADILYCTATANFGQPEIKLGTVPGAGGSQRLTRAVGKSRAMELILTGKSFSGVEAERWGVAARVFDSHEALMEGALQTAETIAGYSRVAVQAAKEVVNKSQDLGLRDGVEYERRVFHALFGSQDQKIGMRAFAEKKKAEWSHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SMX1</accession>
    <name>A0AAN6SMX1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_18894</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854486">
        <property type="protein sequence ID" value="KAK4034286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SMX1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07389">
        <property type="entry name" value="MPP_PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000028">
        <property type="entry name" value="WW domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.70">
        <property type="entry name" value="PhoD-like phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018946">
        <property type="entry name" value="PhoD-like_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038607">
        <property type="entry name" value="PhoD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043904">
        <property type="entry name" value="PhoD_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46689">
        <property type="entry name" value="MEMBRANE PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46689:SF2">
        <property type="entry name" value="WW DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G06520)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19050">
        <property type="entry name" value="PhoD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="502"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="224"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="348"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="414"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4034286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1251" mass="133637" checksum="599AEF3D1D24838D" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SND1</accession>
    <name>A0AAN6SND1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Carbamoyl-phosphate synthase L chain, ATP binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">C8A01DRAFT_40043</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854526">
        <property type="protein sequence ID" value="KAK4033510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SND1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004485">
        <property type="term" value="F:methylcrotonoyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06850">
        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000003">
        <property type="entry name" value="Acetyl-CoA carboxylase biotin carboxyl carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000003">
        <property type="entry name" value="acetyl-CoA carboxylase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000028">
        <property type="entry name" value="Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050856">
        <property type="entry name" value="Biotin_carboxylase_complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18866">
        <property type="entry name" value="CARBOXYLASE:PYRUVATE/ACETYL-COA/PROPIONYL-COA CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18866:SF33">
        <property type="entry name" value="METHYLCROTONOYL-COA CARBOXYLASE SUBUNIT ALPHA, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0092">Biotin</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="13">
        <location>
            <begin position="51"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="12">
        <location>
            <begin position="175"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="11">
        <location>
            <begin position="678"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="19"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK4033510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="756" mass="81810" checksum="AB4AE45A2EF3219A" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SNH1</accession>
    <name>A0AAN6SNH1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="28">Ketol-acid reductoisomerase, mitochondrial</fullName>
            <ecNumber evidence="7">1.1.1.86</ecNumber>
            <ecNumber evidence="23">2.3.2.34</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">Acetohydroxy-acid reductoisomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Alpha-keto-beta-hydroxylacyl reductoisomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="24 25">NEDD8-conjugating enzyme Ubc12</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="26">RUB1-conjugating enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="27">Ubiquitin carrier protein 12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="34" type="ORF">C8A01DRAFT_49814</name>
    </gene>
    <organism evidence="34 35">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="35" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="35">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>[E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine + [E2 NEDD8-conjugating enzyme]-L-cysteine = [E1 NEDD8-activating enzyme]-L-cysteine + [E2 NEDD8-conjugating enzyme]-S-[NEDD8-protein]-yl-L-cysteine.</text>
            <dbReference type="EC" id="2.3.2.34"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Protein modification; protein neddylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 29">Belongs to the ketol-acid reductoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="34">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.86" evidence="7"/>
    <dbReference type="EC" id="2.3.2.34" evidence="23"/>
    <dbReference type="EMBL" id="MU854518">
        <property type="protein sequence ID" value="KAK4033630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SNH1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004455">
        <property type="term" value="F:ketol-acid reductoisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061654">
        <property type="term" value="F:NEDD8 conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23794">
        <property type="entry name" value="UBCc_UBE2F_UBE2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000003">
        <property type="entry name" value="Ketol-acid reductoisomerase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000005">
        <property type="entry name" value="Ketol-acid reductoisomerase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000013">
        <property type="entry name" value="Ketol-acid reductoisomerase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000167">
        <property type="entry name" value="Ketol-acid reductoisomerase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000005">
        <property type="entry name" value="NEDD8-conjugating enzyme Ubc12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013023">
        <property type="entry name" value="KARI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000506">
        <property type="entry name" value="KARI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013116">
        <property type="entry name" value="KARI_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00465">
        <property type="entry name" value="ilvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21371">
        <property type="entry name" value="KETOL-ACID REDUCTOISOMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21371:SF1">
        <property type="entry name" value="KETOL-ACID REDUCTOISOMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01450">
        <property type="entry name" value="KARI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07991">
        <property type="entry name" value="KARI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51851">
        <property type="entry name" value="KARI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51850">
        <property type="entry name" value="KARI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 29" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="19 29" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="14 29" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10 29" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-0521">NADP</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
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    <keyword evidence="35" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="16" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="12" id="KW-0833">Ubl conjugation pathway</keyword>
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            <end position="173"/>
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            <end position="424"/>
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            <begin position="425"/>
            <end position="572"/>
        </location>
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    <feature type="active site" description="Glycyl thioester intermediate" evidence="30">
        <location>
            <position position="111"/>
        </location>
    </feature>
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        <location>
            <position position="433"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
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        <location>
            <position position="433"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
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        <location>
            <position position="437"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="29">
        <location>
            <position position="469"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="29">
        <location>
            <position position="473"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="29">
        <location>
            <position position="495"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004864"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004885"/>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00013102"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
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    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="33">
        <source>
            <dbReference type="PROSITE" id="PS51851"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK4033630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="35">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="574" mass="63849" checksum="8B19F225BD21746B" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SNJ0</accession>
    <name>A0AAN6SNJ0_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">C8A01DRAFT_39867</name>
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        <dbReference type="NCBI Taxonomy" id="2588326"/>
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            <taxon>Chaetomiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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            <end position="29"/>
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            <end position="58"/>
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            <end position="73"/>
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</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854513">
        <property type="protein sequence ID" value="KAK4033735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF10">
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        <property type="match status" value="1"/>
    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="375" mass="41723" checksum="84A4239BE15E46D7" modified="2024-10-02" version="1">MDPPDVLGSDLNFCRWAYRAWTFQEKALSTRQVLFGNSNVHVLCQHTHESMGDKPEEPIDNNKYQITQAVTSATPTSQLHQSWDALLSLYSTFNETALTYATDILPALAGLARLFQEHLGHDTYICGHWQTTLYHDLMWTLHHKLYALSRQAHLAKLPTRTSRLLPFWSRLLQSRRTVNPFTPGSHNSFHNLRPEYQHLTPDVALPAGSNNPLGAVRHARLHLTTVLLELRGIVMQSEPGLGGDRDEDEEHCGFKWHSDFVDDGGYLDAESPSPIIFRLDRLIVGGMGSEIRSEDTSSAVGGVEESRWALLGSCEVRDGGGGGGRAAFGLVLHAVPGEVGRYWRVGTFVPSVRGRHGDSLGLFRKVGRVETVEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SP31</accession>
    <name>A0AAN6SP31_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fungal-specific transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_39034</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854478">
        <property type="protein sequence ID" value="KAK4034467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SP31"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF28">
        <property type="entry name" value="C6 TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="69"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="134"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="758"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="758"/>
            <end position="771"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4034467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="859" mass="94103" checksum="D76EA96861BD76EF" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SQ53</accession>
    <name>A0AAN6SQ53_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">protein-ribulosamine 3-kinase</fullName>
            <ecNumber evidence="1">2.7.1.172</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_47490</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>N(6)-D-ribulosyl-L-lysyl-[protein] + ATP = N(6)-(3-O-phospho-D-ribulosyl)-L-lysyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48432"/>
            <dbReference type="Rhea" id="RHEA-COMP:12103"/>
            <dbReference type="Rhea" id="RHEA-COMP:12104"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:90418"/>
            <dbReference type="ChEBI" id="CHEBI:90420"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.172"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:48433"/>
        </physiologicalReaction>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.172" evidence="1"/>
    <dbReference type="EMBL" id="MU854414">
        <property type="protein sequence ID" value="KAK4038974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SQ53"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102193">
        <property type="term" value="F:protein-ribulosamine 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016477">
        <property type="entry name" value="Fructo-/Ketosamine-3-kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12149">
        <property type="entry name" value="FRUCTOSAMINE 3 KINASE-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12149:SF8">
        <property type="entry name" value="PROTEIN-RIBULOSAMINE 3-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03881">
        <property type="entry name" value="Fructosamin_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00048655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4038974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="347" mass="39599" checksum="CCD4A0B526BE3F54" modified="2024-10-02" version="1">MATDARDVEEKQKLDENLLAALPEGGEVVSVTPSGMSDYCNTYRIEVKMPDGSSQVFFEKEGSGEEGLGCVESAFVSESAAYEFIPEHVPRPVTMGTYKARPDKHFFLAAFIEMIEDDIPREESYMAAVAALHSRSMGKSPTGKFGFPVNTRFGNLEQDNTWAASWEEYWTRQMKDFLDKEDAAHNGEPHEELDRLRPLFFEKVLPRYLRPLESDGRSVTPCLIHADLWPGNVKYMSDGETACMYDACAMWAHNEVDLGVFRNPRYPLGKPYLKEYWKHVPISEPEEDVDSRNTLYMLRGQILLSILYPHDPKLREIFVSNMRLLVERVHEEEVAQSNSSGPVQFHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SQF0</accession>
    <name>A0AAN6SQF0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Rieske domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_16730</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854405">
        <property type="protein sequence ID" value="KAK4039274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SQF0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03467">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21496">
        <property type="entry name" value="FERREDOXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21496:SF0">
        <property type="entry name" value="RIESKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="6">
        <location>
            <begin position="63"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4039274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="178" mass="20022" checksum="631ADEFEAAAF2DE1" modified="2024-10-02" version="1">MNILLNPFRGPSRTGGEWFSVGVVSSFPDLGLDETESEPQPQLCGNQGAQPGCKVFHVPKTDSSQRTEVEIPPDDTVQDLTDQVLVFQYRGKFHAIDHQCPHSSYPLSQGTPFDIEDFGIVLSAGLTCPKHNWSFDLFSGRSDRGNYKLKIWEVQLRETEGTTTDDKEVWVRRKPRIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SQM0</accession>
    <name>A0AAN6SQM0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mechanosensitive ion channel protein 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_47868</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854426">
        <property type="protein sequence ID" value="KAK4038541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SQM0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058650">
        <property type="entry name" value="Msy1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31323">
        <property type="entry name" value="MECHANOSENSITIVE ION CHANNEL PROTEIN MSY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31323:SF14">
        <property type="entry name" value="MECHANOSENSITIVE ION CHANNEL PROTEIN MSY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25886">
        <property type="entry name" value="Msy1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="105"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="415"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="Mechanosensitive ion channel protein Msy1/2-like transmembrane" evidence="3">
        <location>
            <begin position="55"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="732"/>
            <end position="772"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4038541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="772" mass="86565" checksum="70A8A808AB7F54AC" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SQX2</accession>
    <name>A0AAN6SQX2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycosyltransferase family 28 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_16729</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854405">
        <property type="protein sequence ID" value="KAK4039292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SQX2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016906">
        <property type="term" value="F:sterol 3-beta-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000100">
        <property type="entry name" value="Glycosyltransferase family 1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000009">
        <property type="entry name" value="Sterol 3-beta-glucosyltransferase UGT80A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010610">
        <property type="entry name" value="EryCIII-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050426">
        <property type="entry name" value="Glycosyltransferase_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004276">
        <property type="entry name" value="GlycoTrans_28_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050:SF27">
        <property type="entry name" value="GLUCOSYLTRANSFERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G04880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06722">
        <property type="entry name" value="EryCIII-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03033">
        <property type="entry name" value="Glyco_transf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyltransferase family 28 N-terminal" evidence="3">
        <location>
            <begin position="62"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Erythromycin biosynthesis protein CIII-like C-terminal" evidence="4">
        <location>
            <begin position="373"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="571"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="574"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="613"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4039292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="830" mass="88806" checksum="3857F12618FC9B71" modified="2024-10-02" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SQY0</accession>
    <name>A0AAN6SQY0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ToxD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_37210</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854418">
        <property type="protein sequence ID" value="KAK4038798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SQY0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF7">
        <property type="entry name" value="ZINC BINDING OXIDOREDUCTASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042917197" evidence="3">
        <location>
            <begin position="19"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4038798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="169" mass="18410" checksum="EC329C4DF2957286" modified="2024-10-02" version="1">MKALLLNTPLTTASLCLTTPLPTPQHHTDLLIRVEAVALNPVDALYTSHPLGATGRTVGSDFAGMVVQGTEPIYGAVWEGLGVEIQYQGFVVPASAEARRFAATFYKWLSKGGKLEANPIRLMPGGLDRVVDDGFVLLGSGTMEARQRDRTEEWMRPISAEKLVYRVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SQZ5</accession>
    <name>A0AAN6SQZ5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_47399</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854411">
        <property type="protein sequence ID" value="KAK4039065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SQZ5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000034">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF48">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G01000)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="286"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="337"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="362"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="385"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="423"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="454"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="64"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4039065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="512" mass="56183" checksum="6BE84336D240FE62" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SRM2</accession>
    <name>A0AAN6SRM2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_46119</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854374">
        <property type="protein sequence ID" value="KAK4040564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SRM2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01709">
        <property type="entry name" value="RT_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37015">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37015:SF1">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4040564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="905" mass="103202" checksum="C783B6566BEA1DF0" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SRN9</accession>
    <name>A0AAN6SRN9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Pectate lyase superfamily protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_46492</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854384">
        <property type="protein sequence ID" value="KAK4040087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23668">
        <property type="entry name" value="GH55_beta13glucanase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039279">
        <property type="entry name" value="QRT3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024535">
        <property type="entry name" value="RHGA/B-epi-like_pectate_lyase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33928:SF2">
        <property type="entry name" value="PECTATE LYASE SUPERFAMILY PROTEIN DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33928">
        <property type="entry name" value="POLYGALACTURONASE QRT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12708">
        <property type="entry name" value="Pect-lyase_RHGA_epim"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase" evidence="7">
        <location>
            <begin position="130"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase" evidence="7">
        <location>
            <begin position="485"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="6">
        <location>
            <begin position="1473"/>
            <end position="1667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="958"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1273"/>
            <end position="1306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1286"/>
            <end position="1297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4040087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1961" mass="210284" checksum="7D85938FCF4DC8D1" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SRR2</accession>
    <name>A0AAN6SRR2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_35850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854383">
        <property type="protein sequence ID" value="KAK4040162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SRR2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="104"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="135"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4040162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="301" mass="33366" checksum="AD023DC1C91F17B5" modified="2024-10-02" version="1">MVAGLGNSLVLFHNLHTLSAHILTHVVLSRPLSPTTSASLSDADPAEMGNLFSKHKDKSRPSSGGSGGGSYYAPSAARPPFNGQTGGYQPPHRENGYSIDPREQQQQQQRQQRQQRQQQYQPAPAPTGQRRHAPKQQPAPQTQTNPKPPKNILPEYHLEVYCITCCKGKGKGKGKGKGKGKGKGKDKGTPQCRITLNLNMSLENKSAYRNAWNNGSDEKWALGIDFCDWSVYRAGKDKVAEEVIKRVCRVQEDWDSDDSEIESRWGKKKRTKKEVEERGPFCVDKLLDGLTARGVDFLSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SS40</accession>
    <name>A0AAN6SS40_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_35701</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM234 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854380">
        <property type="protein sequence ID" value="KAK4040280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SS40"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018908">
        <property type="entry name" value="TMEM234"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28668">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28668:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10639">
        <property type="entry name" value="TMEM234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4040280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="151" mass="16726" checksum="9D39EDBF1D075ECC" modified="2024-10-02" version="1">MQDPQQQPPAINFILSFLLVGLAWGLTTPFIRRAARDHRPPAHPVLASAKVQQSWLRKRVYAAFFAVVDLLRNPRYAVPLVLNLTGSVWFFLLIGKAELSLTVPIVNTLAFLFTVVGEWWVEGKVISRDTMLGMLLSVGGIALCVQSKNAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SSE4</accession>
    <name>A0AAN6SSE4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Short-chain dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_15561</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854373">
        <property type="protein sequence ID" value="KAK4040595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SSE4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF236">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4040595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="339" mass="36596" checksum="84411D8357B11E90" modified="2024-10-02" version="1">MFRSQLSQFFPRKPAFTEPDVASQQGKVFLVTGGASGIGLEIAKILYQKGGRVDIAGRSEENARRAIRDIQTATPSSSNGSLEYLHLDLSDLTTVQPAVTAFKAKEPALHVLFNNAGVSQPPLGSLSAQDIELQLATNCLGPFLLTQLLLPTLEATAAATSPSAPGTVRVVWTASQMMELTAPPEVLVMSELRAPPKDTTRNYVNSKTGNYLLAVELARQQQQKQTQAASLGSNAAPVLSVSTNPGAASTNLFRHTRLMGYLAWPLLQPARLAALTQLYAGLSGDVAVEGNGCYVVPWGRVAKFMRQDLRDAAKLEEDRGSGRAREFWEFCEEMTGGYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6ST54</accession>
    <name>A0AAN6ST54_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_34341</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854354">
        <property type="protein sequence ID" value="KAK4041617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6ST54"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11060">
        <property type="entry name" value="CYP57A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000050">
        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF232">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="4 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="475"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4041617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="527" mass="58783" checksum="2DBC33D7543055BF" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SUB5</accession>
    <name>A0AAN6SUB5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_32525</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854328">
        <property type="protein sequence ID" value="KAK4043399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SUB5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4043399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="125" mass="13928" checksum="A9E161EE4CD12166" modified="2024-10-02" version="1">MDFCFSCQRFNIHALRRIPGGWRTYQLKLARDGARSGCSSCGLLVESLWSKIPADRQSSLDEEQTRIFLRATHSRRLSASRDACTTKTAALQMDGLQAFIAPAAYEIDGQQPVKESTATFHVCAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SUG9</accession>
    <name>A0AAN6SUG9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_32292</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asaB hydroxylase/desaturase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854326">
        <property type="protein sequence ID" value="KAK4043564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SUG9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044053">
        <property type="entry name" value="AsaB-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041278">
        <property type="entry name" value="CmcJ_NvfI_EfuI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598">
        <property type="entry name" value="BLL6449 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598:SF1">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G13140)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4043564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="288" mass="31757" checksum="56EC54E7ACDCD5D8" modified="2024-10-02" version="1">MTTTHEPPRGDVVATLNFYSPPEDGSAPYNLAGDAPPDVPPRNFGSVAHDVLIHDARGKESSFTLDHDAFQILLNQPPSAETSFTDDASIRKNYYPEVERLLLDTVPGANKVIIFDHTIRRPNTSRQPVARVHIDQTAHSTAQRIHRHAPSATEASRLLATTRYRIINVWRPLNARPVESSPLAFASSSTLRDADVVPVEHRYPASAGGYVGQTAAIQYDAGQKWYYLSGMTGDERVLLECFDSEAFKEDNSVVKGGRVPHSAFEDPRTREGAEGRESIEVRALVFGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SV21</accession>
    <name>A0AAN6SV21_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TATA-box-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_12473</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854321">
        <property type="protein sequence ID" value="KAK4044179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SV21"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04516">
        <property type="entry name" value="TBP_eukaryotes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000001">
        <property type="entry name" value="TATA-box-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00408">
        <property type="entry name" value="TATA_bind_prot_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000814">
        <property type="entry name" value="TBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033710">
        <property type="entry name" value="TBP_eukaryotic"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10126">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00352">
        <property type="entry name" value="TBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00686">
        <property type="entry name" value="TIFACTORIID"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55945">
        <property type="entry name" value="TATA-box binding protein-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4044179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="229" mass="25882" checksum="D711A36EBE33AFB6" modified="2024-10-02" version="1">MQTRSHTSPSHQHEPTPPQQPQQRSWRDRVKPDWPLPQIQNVVATVNLDCRLDLQTIAQHARNVEYNRKKFHALVMRIRSPRTTTLVFASGRLVVTGAKSEDLARLAARRHARAIQKCGFRTKFLDFKVQNFVGSATCDFLIRLEGIAHGYPQFAMHEPELFPGLVYTMVRPALKCLVFTTGKVVLTGAKSVEDVFEAFANLYPLLLEAKVMGSTAPGPKAKGLRKRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SV32</accession>
    <name>A0AAN6SV32_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">K(+)/H(+) antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_31522</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854320">
        <property type="protein sequence ID" value="KAK4044209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SV32"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050794">
        <property type="entry name" value="CPA2_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32468">
        <property type="entry name" value="CATION/H + ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32468:SF0">
        <property type="entry name" value="K(+)_H(+) ANTIPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="162"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="199"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="349"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="382"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="413"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="9">
        <location>
            <begin position="43"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="449"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="737"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="835"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="837"/>
            <end position="870"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4044209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="910" mass="96587" checksum="4A2457F86DD36032" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SV65</accession>
    <name>A0AAN6SV65_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_32370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854327">
        <property type="protein sequence ID" value="KAK4043445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SV65"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4043445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="185" mass="20832" checksum="1F00C9CD6C95C556" modified="2024-10-02" version="1">MASKENDKYVSSSSRSEADIPGAPVTAEETEERDEAIINAVQQDPRFSKLTDCRQIRFAHIMRYYKDDGHNAPGHSVLDFSDNAPFRVKGSKFKFIPCKNGNLVSEEFSGGDGRPSKRHKLRNMTAEEAAAQDAPDSPCDCELCKKRRENGFEKAESKDDLKPEVGLRSGMKRKWDEKYGEGRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SW59</accession>
    <name>A0AAN6SW59_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_42648</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DAMOX/DASOX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854318">
        <property type="protein sequence ID" value="KAK4044465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SW59"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003884">
        <property type="term" value="F:D-amino-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006181">
        <property type="entry name" value="D-amino_acid_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023209">
        <property type="entry name" value="DAO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530">
        <property type="entry name" value="D-AMINO ACID OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530:SF26">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE SUPERFAMILY (AFU_ORTHOLOGUE AFUA_5G13940)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000189">
        <property type="entry name" value="D-aa_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00677">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="7">
        <location>
            <begin position="4"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="51"/>
            <end position="52"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>D-serine</name>
            <dbReference type="ChEBI" id="CHEBI:35247"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000189-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4044465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="369" mass="40089" checksum="8EA34B6E516B0C61" modified="2024-10-02" version="1">MPQHVVVVGAGVIGLSSAILLQQARYTVTIVARDFPAPFETMDPLTKINYTSPWGGAHNRWVPPHPSLPATLAREHAFSLRTYTHMQNLHASHPDTAGITFLKGVEYLERPGPEHLALSTPSNPNALNLPGNFRLLEESEFPADGGRVKWGCEYDTWCVNPMVYCSFLLRRFVHRGGRVVARELRRPEEVFAMIGSELGGNDGEAVAAVVNASGTGLVPDPDMTITRGQTCLVAEDCDATVTRQNADGSWTFCVPRGFEGGTVIGGTKEVNNWDVKPSMEVRAELLKKFGETYPKILGEKGELTVVRDIVGRRPTRNGGPRVEGEVMPGAGFVMHAYGLGGRGYELSWGVAEAVVEGVEAQIRGAEARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SWI2</accession>
    <name>A0AAN6SWI2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_42464</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854316">
        <property type="protein sequence ID" value="KAK4044855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SWI2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039751">
        <property type="entry name" value="HERPUD1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12943:SF27">
        <property type="entry name" value="HOMOCYSTEINE-INDUCED ENDOPLASMIC RETICULUM PROTEIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12943">
        <property type="entry name" value="HOMOCYSTEINE-RESPONSIVE ENDOPLASMIC RETICULUM-RESIDENT UNIQUITIN-LIKE DOMAIN HERPUD PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="526"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="560"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="7">
        <location>
            <begin position="45"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="193"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="337"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="456"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="602"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="683"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="339"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="361"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="479"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="503"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="605"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="683"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="695"/>
            <end position="711"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4044855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="755" mass="81504" checksum="931AEE3407722D91" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P414</accession>
    <name>A0AAN6P414_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CAP-Gly domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_42201</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854860">
        <property type="protein sequence ID" value="KAK4031338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P414"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032108">
        <property type="entry name" value="CLIP1_ZNF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916">
        <property type="entry name" value="DYNACTIN 1-RELATED MICROTUBULE-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916:SF83">
        <property type="entry name" value="TIP ELONGATION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16641">
        <property type="entry name" value="CLIP1_ZNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CAP-Gly" evidence="9">
        <location>
            <begin position="122"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="191"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="399"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="531"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="576"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="651"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="705"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="753"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="783"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="357"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="613"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="268"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="531"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="543"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="580"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="602"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="688"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="795"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="809"/>
            <end position="821"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4031338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="875" mass="93736" checksum="1361F3095FA14D82" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P4A4</accession>
    <name>A0AAN6P4A4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_21448</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAK4031315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P4A4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4031315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="68" mass="7471" checksum="10E4C036AF145F15" modified="2024-10-02" version="1" fragment="single">SGSGDRTVRVWDAATGAKRRVLRGHSCSVNAVVFSLDSRLIGRHMPSCSRMLSENSVFARNPRARLTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P4I5</accession>
    <name>A0AAN6P4I5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_21217</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854752">
        <property type="protein sequence ID" value="KAK4031591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042816615" evidence="1">
        <location>
            <begin position="20"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4031591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="62" mass="6598" checksum="1BEBB8D477168BCB" modified="2024-10-02" version="1">MLANKRALLLLAFVATSFGQYTGPCSTSAYGAEGKPCARGYLCVPWPTFDPAQRKGCTCSYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P4M2</accession>
    <name>A0AAN6P4M2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Kelch repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_21140</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854727">
        <property type="protein sequence ID" value="KAK4031684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P4M2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019760">
        <property type="term" value="P:glucosinolate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47435">
        <property type="entry name" value="KELCH REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_5G12780)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47435:SF4">
        <property type="entry name" value="KELCH REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_5G12780)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042820150" description="Kelch repeat-containing protein" evidence="3">
        <location>
            <begin position="23"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4031684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="294" mass="33089" checksum="9292AD46B6D011AD" modified="2024-10-02" version="1">MRRRKIGVLAPVLCLAVHRATADVPQNPRDNFCRRIGHQTTFIDDKLYIDSSFVNFDTFPTDNKTYPNTWLGFQDFDNLTLRSDDALWPNLNIGLNKDPNTIPTVHGGALWGDSVNKRFFLFGGENTKGVASTDFHLLSYDILNDEWDDFGPPDMPNPPNISSYGAGVGVSETGQGYYYGGWISNASMRGWTQDRTMSSAFYKYEYDTNATTGAKPPDELPRAEGAMVWIPAGYTELLIYFFQQRPALFSAAESTELHSLQNEQSRQHDRLCRAGTALQLSHWEMHVLVGSNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P4P2</accession>
    <name>A0AAN6P4P2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_21123</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854721">
        <property type="protein sequence ID" value="KAK4031714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P4P2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37542">
        <property type="entry name" value="HELO DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37542:SF3">
        <property type="entry name" value="PRION-INHIBITION AND PROPAGATION HELO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="42"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4031714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="389" mass="43026" checksum="DD60A2BDBE4C16C0" modified="2024-10-02" version="1">MPLVRLSPTFYNIDSLRAFPSLEATAGGNEQVHLASSLANLKIIAGNLGQRATGARKKPIPWKSVKTGDDGEKELLLEPCKDDREVAELYSTNLGTGPVLIEWKVVPVVLPLEQKDKLKDRVYNLGTVLKATGKPSEIRTLDYMGILEKPVGDTADKEYGIVFRIPGGQTPFSLHSRISEPGTTPSLDQKFSLARALANAVLFLHLASWLHKGIRSDNVLFFAASTSTIDLTEPYLGGFEYSRFNERSTLTENTDDDLEHNLYRHPEHQGWPMSGDGHKQRTTRKSFTYRADLYSLGVTLLEIGLWETAAQIYTASAPKAAEGKRRKQSFETAFLGKLPLLRAQIGGIYTGVTERCLQGDFELNYSGEAGTIQEAFYISAIRPLESCTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P5X7</accession>
    <name>A0AAN6P5X7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">alcohol dehydrogenase (NADP(+))</fullName>
            <ecNumber evidence="9">1.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">C8A01DRAFT_20686</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a primary alcohol + NADP(+) = an aldehyde + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15937"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15734"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:15938"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="10">
            <dbReference type="Rhea" id="RHEA:15939"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.2" evidence="9"/>
    <dbReference type="EMBL" id="MU854634">
        <property type="protein sequence ID" value="KAK4032215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P5X7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008106">
        <property type="term" value="F:alcohol dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006066">
        <property type="term" value="P:alcohol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05283">
        <property type="entry name" value="CAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000158">
        <property type="entry name" value="Zinc-binding alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047109">
        <property type="entry name" value="CAD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42683">
        <property type="entry name" value="ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="12">
        <location>
            <begin position="21"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK4032215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="371" mass="39871" checksum="08A76563431E61A3" modified="2024-10-02" version="1">MSSTDYKFEGWLGLDKSAAEGNMKWAEFEPKPWEETDVDIKITHCGICGSDIHTLRSGWGPTNYPCCVGHEIVGTIVRVGSKVEGGLKIGDRVGVGAQSDSCQSRKGDCEACASGMENYCGKHHVGTYNGVYLNGGKSYGGYALYNRSPSHFVVKIPDAISSAEAAPMLCGGVTTYTPLKHHGVGPGKTVGIIGLGGLGHFGVMWAKALKADKVVVISRTSAKKEDALKMGADEFVATAEDPVWAKKHASTLDVIVCTVSSSSMPLMQYLSLLRFDGTFVQVGAPEDGLPTIQQFPLIFKRLKITGSLIGSPSDIREMLQLAADQKVKPWIEQIPMKDANKAIVDLEAGKPRYRYVLVNEQEGASQVRAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P6I7</accession>
    <name>A0AAN6P6I7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_50679</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854597">
        <property type="protein sequence ID" value="KAK4032545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P6I7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF151">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="24"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="298"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="357"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="446"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="24"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4032545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="489" mass="53034" checksum="D664D95AA629C802" modified="2024-10-02" version="1">MVTTSLKDQPTRSPYTTWTTQDRTLLVCLLGYLALASSLTANIYFPLIDLLAERYETSTQAINLTITLYFVFQGIAPSFWSPLSDSFGHRPVYLATFTIYTAASLGLSIVDRSYPALLLLRALQSIGGSAVLSLAYAVVADVAVHSERGRFLAPMLTATNVGPCIGPIIGGGALASRDPRWCFRALLIFGASAVLLIGLVQPETARTVVGNGAVPAKGLCRTWLSLIFPTRVQEPDINTGKTGRGKFIFPNPLPSLRIVFHPDSFLTLWLAGCPYALWFCVQTSITPVFRRSYGFNPLEVGCCFLAGGAGIIAGGFVVGRLMDKNYKHVAKKAGFTIDRVRGDDVARFPIEHARSRWSVSIVVVSMFFVVGYGWAVERRVHAAVPLLLQAYLGCKCTVVHQTYSALIVDVFPNTTGTAAAANNITRCALAAAGVAMLDPLVSALGYGWVFTLLGLFDAISCVLAVVALRRWGRIWRDKRADRLKDPGNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P6Z6</accession>
    <name>A0AAN6P6Z6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_40623</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854564">
        <property type="protein sequence ID" value="KAK4032914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P6Z6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF68">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01120)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="193"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="228"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="258"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="395"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="426"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="459"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="499"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="528"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="131"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4032914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="569" mass="61520" checksum="9E5444FCDBFB5DBB" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P779</accession>
    <name>A0AAN6P779_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">2-methylisocitrate lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_20057</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854562">
        <property type="protein sequence ID" value="KAK4032949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P779"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00377">
        <property type="entry name" value="ICL_PEPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039556">
        <property type="entry name" value="ICL/PEPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42905:SF16">
        <property type="entry name" value="CARBOXYPHOSPHONOENOLPYRUVATE PHOSPHONOMUTASE-LIKE PROTEIN (AFU_ORTHOLOGUE AFUA_5G07230)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42905">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13714">
        <property type="entry name" value="PEP_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4032949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="268" mass="28240" checksum="43EAF9E535A10F5F" modified="2024-10-02" version="1">MTTATPSIAALAAQATAFKALHVPGTPLLLANVYDATSARIIGSQPNCRALASASYALAKTIGLKDEQLTLEHNLALCAPIAAVARELGLPLTVDIQDGYGDRLEEVVRRVITELGAVGVNLEDSFHEGGGVMGEEEAVGRVRRVLEVAREVGVPDFVVNARSDSFLKGGELDESIRRGRRFLEAGATTVYVFWPPSREMVEGDVKRVIDGLDGLANIQPRKVSPVQSKALSSADIARLGAARVSVGPQLYLAAAAVLTAAANEVFAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P783</accession>
    <name>A0AAN6P783_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_19975</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854557">
        <property type="protein sequence ID" value="KAK4033033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P783"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000034">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF67">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G04010)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="284"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="327"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="382"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="414"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="449"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="50"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4033033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="498" mass="54532" checksum="F75620BF0C220553" modified="2024-10-02" version="1">MSSMHDVERDSEKVESDEVDATTPDAITHLTPQDEAHLAKRVLFKTDTRILPILSLLFLCSFLDRTNVGNAKIIGLESDLGISNLQYNQGLAVFYATYIASELPSNLILKSLTPTIWLPLLTAIWGIITMCLGFVHNFASFFAVRALLGLAEGGLLPGIVLYLSGMYTRREMAVRIGVFYTAASLSGAFGGLLARGLSAIGPRGGLEGWRWIFIIEGLITVVAASVAYLLLPTSIATASYLTPEEKEFALRRLQGHTQSAGSDRFNPVLEREERFKWSEVRRGIFNLQVWLSATAYFSILSGLYSFGLFLPTIINDLHITSSANETQLWSVIPYAVATPITVLVALLSDRLNLRGTLMLATLPVSIAGYAAIANVASANARFAMTCLMAIGMYASVPCVLVWNSNNSAGHYKRATTSALQLAVANCGGFVATFVYPSNEGPLYHKGHTIILWLLVYAWFAILANVLWCSKINKDKKSGKYAQYEGSGDDRDPRFKMVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P7D1</accession>
    <name>A0AAN6P7D1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="10">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">C8A01DRAFT_40428</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>feruloyl-polysaccharide + H2O = ferulate + polysaccharide.</text>
            <dbReference type="EC" id="3.1.1.73"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the tannase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="10"/>
    <dbReference type="EMBL" id="MU854551">
        <property type="protein sequence ID" value="KAK4033106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P7D1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030600">
        <property type="term" value="F:feruloyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011118">
        <property type="entry name" value="Tannase/feruloyl_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938:SF15">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07519">
        <property type="entry name" value="Tannase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042667343" description="Carboxylic ester hydrolase" evidence="10">
        <location>
            <begin position="20"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK4033106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="528" mass="56927" checksum="DA557FEFD629AD4C" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P7R0</accession>
    <name>A0AAN6P7R0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_51156</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854677">
        <property type="protein sequence ID" value="KAK4031928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P7R0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4031928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="210" mass="23552" checksum="5CFEB61AC4FC05B0" modified="2024-10-02" version="1">MVPLMFKAEWSIEIDSRKPPPEEDSDPSLRTVGDNGRGAVDAPVPELRVATEARFADFDKSPVTHVVIQVTTTRQRDISRYVGYRYDWKFPSPFWAFLGKIAEKGVFDDDGATTLKELRYIPVGRREFIAYTTPLWRAAVEAIQAAKAAAAAGAGIPELPPISALEVTFKKPQHGQPLEMTWIPVRPLITARIKRWNDESDDEENVDVSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P849</accession>
    <name>A0AAN6P849_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RTA1 like protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_20424</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854601">
        <property type="protein sequence ID" value="KAK4032510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P849"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF8">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14140)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="314"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="318"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4032510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="375" mass="40604" checksum="0D660209704F05C9" modified="2024-10-02" version="1">MDVDKLDPSMFPPGMDQDDMDDAIANYYYSCTQVTALCPVEATTLGYYPNRGINIFFAIGFAAATVTALVLGARKKTWSYTGFIAAGCALELAGYGARVPLTDNPWNKHAFETQIVAIILAPTLICISIYLTLKHVCLALNPALSRVRPHLYPFIFVPLDVSCLLVQAIGGALAASAATTNFKMVQHGNRCIIAGIVLQVVVLSFFGASAGDYILRVKKWINSPEADPEAVALWRDKKFRMFMYAVTGAYSGILIRCLYRIAEMAGGWGNHIMQDEPSFIVLEGFMVLIPCILLAVFAPGYLFPQMAARMSAPGRVGLSREKGGETEAEKQPHTEGLGGQQQTTSGDESALGEERTKEQPASTAAVVEPNSRESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P8D0</accession>
    <name>A0AAN6P8D0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">OTU domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_49815</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854518">
        <property type="protein sequence ID" value="KAK4033631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P8D0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22762">
        <property type="entry name" value="OTU_fungi_OTU2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049771">
        <property type="entry name" value="OTU2-like_OTU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050704">
        <property type="entry name" value="Peptidase_C85-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419:SF10">
        <property type="entry name" value="DEUBIQUITINASE OTUD6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419">
        <property type="entry name" value="OTU DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OTU" evidence="2">
        <location>
            <begin position="180"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="146"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4033631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="356" mass="38591" checksum="F99A869970D0C4C1" modified="2024-10-02" version="1">MQDGESLEQMQARHRKEQRDLQSRVTNKKKNATKKTRKFVNDECAQLERELRERQEGEVRALRGEADGLDTDGDDDDEQLPSRQPPRSEEDAPPTAATDLASKLASATLSPSQPAAKQGGGGEQKEQVKQKRNRQKERLARRAAEQEAAAAQAASEAAAMPDERALERRAMQASFAAHALREHEIAPDGHCLFSAVADQLGLNGIPLAEGGKGTGTGTDGEGAGVDMAVAQGEAGLKPKVEMPYRVVRRAAADWISGHREVYEGFLEEGVDGYVERIRDTAEWGGELELSALANAYGVEIRVVQGGGRVEVVKPEAQAAAGEEGKGEEKGKTLWLAYYRHGYGLGEHYNSLRKAGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P8N3</accession>
    <name>A0AAN6P8N3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_20155</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854572">
        <property type="protein sequence ID" value="KAK4032827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P8N3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35394">
        <property type="entry name" value="DUF3176 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35394:SF5">
        <property type="entry name" value="DUF3176 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="302"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4032827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="326" mass="35900" checksum="3B4E0C6FE7A4DDD7" modified="2024-10-02" version="1" fragment="single">SMKGNQLFENITEAHTVLDPGSWRRTSNNSDEPQFPEFVPPPGSLEFDPLYSLASYSPLLLNDPITNVSYRVDDGSVKSISAYFQSLFSVNFSRDDAPVPGLADELEKLLHKGAVGINGGSFCSPDLQLPINASPPALKNLWKWNRYNIARTFYTLATSMTNEMRRNPADAVSPPSDQDTDGMMTLKGNKRTWTVLYEIQWAWMVLHGITLLLGFVFLGITLWDSGRAEHVPLWKSSTLATIRRGYQIGGALEGADTVHEMESAARKAYVEVPSRDLEESAACIQEDQASSAGEPDTDRASASEARSSLGSSISSHWRDPTRGRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P8Q7</accession>
    <name>A0AAN6P8Q7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_40754</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854574">
        <property type="protein sequence ID" value="KAK4032810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P8Q7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159">
        <property type="entry name" value="CENTROSOMAL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159:SF31">
        <property type="entry name" value="CENTROSOME-ASSOCIATED PROTEIN CEP250 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="598"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="673"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="53"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="682"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="699"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4032810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="734" mass="81621" checksum="F41A0276BFA111A7" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P8S4</accession>
    <name>A0AAN6P8S4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SPS1, Serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_51399</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854762">
        <property type="protein sequence ID" value="KAK4031562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P8S4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00381">
        <property type="entry name" value="KINESINLIGHT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4031562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="202" mass="22646" checksum="5E2A900FDD12A799" modified="2024-10-02" version="1">MRIEQFLQEEVLGSDHPDTLTSMGNLASTYWNQGRWEEAEKLEVQVMETRKTKLGADHPDTLTSMDNLALTYGNQGQWEEAETLQVQVMETSKTKLGADHPHTLTSIGNLAATYVYQGRWEEAETLSVQVIETLKTKLGADHPHTLISMANLAFIWKGIGRYEDALGLLQTCFDLRQQVLGVGHPDTASTLSTLKAWLEENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P967</accession>
    <name>A0AAN6P967_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Retinol dehydrogenase 14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_51037</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854650">
        <property type="protein sequence ID" value="KAK4032091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P967"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4032091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="363" mass="39420" checksum="5953614A39EDC2EF" modified="2024-10-02" version="1">MAPPQPLEFPIQPKLGHSIGVFLCSQLFRTPAYPTNSFAGQTVIVTGSNAGLGLEAARHFYRLGAARLILAVRTVSKGQAAKEDIARSITSQTDADSIEVWPLDQSSTPSTLAFAERVRTGLPRVDVVVLNAGLNNPTFQLSDEGYEQTVQVNVLNTFLLALALLPKLNHTKANFSDSTPHLTVISSEAHRLTSFPEINAPDLYAKLNEERAYAQQPRYQVSKLLEVLLVRELVARLKLKSAAASESESNSNNKAPPVIINLVNPGLCNSTLGSSPDAKPPSLLVRLLRGVLDRTTEVGARTYVLAASALAGSHGEFQSDGLNQEVEAWIYTDVGRRVQRKVWEQTVRVLEARRPGILEGVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P9H2</accession>
    <name>A0AAN6P9H2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Histone deacetylation protein Rxt3-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_19791</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854543">
        <property type="protein sequence ID" value="KAK4033245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P9H2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061574">
        <property type="term" value="C:ASAP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.20">
        <property type="entry name" value="LCCL-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052793">
        <property type="entry name" value="EJC-associated_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036609">
        <property type="entry name" value="LCCL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013951">
        <property type="entry name" value="Rxt3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46589">
        <property type="entry name" value="APOPTOTIC CHROMATIN CONDENSATION INDUCER IN THE NUCLEUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46589:SF1">
        <property type="entry name" value="APOPTOTIC CHROMATIN CONDENSATION INDUCER IN THE NUCLEUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08642">
        <property type="entry name" value="Rxt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69848">
        <property type="entry name" value="LCCL domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="583"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="730"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="991"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="110"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="626"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="665"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="684"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1013"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1081"/>
            <end position="1092"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4033245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1121" mass="123424" checksum="EC5805DDA6F9599B" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P9U9</accession>
    <name>A0AAN6P9U9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADH(P)-binding-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_20073</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the avfA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854564">
        <property type="protein sequence ID" value="KAK4032918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P9U9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15020">
        <property type="entry name" value="FLAVIN REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15020:SF50">
        <property type="entry name" value="UPF0659 PROTEIN YMR090W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="2">
        <location>
            <begin position="13"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4032918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="266" mass="28373" checksum="21D57B105185403E" modified="2024-10-02" version="1">MPPSSPHHVLLLGGHGKIAQLLTPLLLRRGWDVTSVIRSEEQVPTIRGLAEDGEGDGKLSVLVRSLEEVKSEGDAKRVVEEVGGDYVVWSAGAGGKGGSERTYAIDRDAAIHFIRAAAAGPQVTRFLMVSYLGSRRAAPAWWSADAWAAAQHVNERVLPHYYRAKLAADEVLYSVSKASGGAFVGINLRPGTLTLDPAGRVELGKTGDSAGKVSRESVARVADLLLASEGIKNTWLDLLDGEEEVEGAVERVVREGVDAAEGEEIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P9Z5</accession>
    <name>A0AAN6P9Z5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_49911</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854524">
        <property type="protein sequence ID" value="KAK4033530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P9Z5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033229">
        <property type="term" value="F:cysteine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000483">
        <property type="entry name" value="Related to allantoate permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF63">
        <property type="entry name" value="HIGH AFFINITY CYSTEINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="84"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="151"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="246"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="312"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="349"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="376"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="404"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="440"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="467"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="84"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4033530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="533" mass="59973" checksum="9398536FB8E32D97" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PAG9</accession>
    <name>A0AAN6PAG9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Class I glutamine amidotransferase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_39780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854511">
        <property type="protein sequence ID" value="KAK4033772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PAG9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03139">
        <property type="entry name" value="GATase1_PfpI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052158">
        <property type="entry name" value="INH-QAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43130">
        <property type="entry name" value="ARAC-FAMILY TRANSCRIPTIONAL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43130:SF15">
        <property type="entry name" value="THIJ_PFPI FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G14240)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DJ-1/PfpI" evidence="2">
        <location>
            <begin position="37"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4033772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="283" mass="31385" checksum="020C04A43CF74A42" modified="2024-10-02" version="1">MHSERKLSTAYKLALSIIAKETGAVSAGYGYRLYAAAKLVATHTFGDAPALDVLFVPGGFGNVALDQANDTSIQTFLRNRFDAVDYLLSVCTGSVFLASSGLLNGHRATTNKMSWDWVTSHGENVTWVPSARWTQDGKIWTSSGVAAGIDMTYAFLKHLYGEDDPVLIRTMNGIEYAPHTDPNWDPFSIVHNRRDSEEGNLFGDSKPSRSHADSADDATHQEPQQNHHDRLAGSIAVIRLEVEDMRERAEIKALMLIWASVLKDEAESYSRIRGRILKLAFRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PC74</accession>
    <name>A0AAN6PC74_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_17663</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854436">
        <property type="protein sequence ID" value="KAK4038216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PC74"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11060">
        <property type="entry name" value="CYP57A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000050">
        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF232">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="4 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="472"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4038216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="538" mass="61156" checksum="FE84EBC218D1B32F" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PCG2</accession>
    <name>A0AAN6PCG2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_37724</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854432">
        <property type="protein sequence ID" value="KAK4038336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PCG2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013595">
        <property type="entry name" value="Pept_S33_TAP-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051601">
        <property type="entry name" value="Serine_prot/Carboxylest_S33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248">
        <property type="entry name" value="2-SUCCINYL-6-HYDROXY-2,4-CYCLOHEXADIENE-1-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248:SF25">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08386">
        <property type="entry name" value="Abhydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="5">
        <location>
            <begin position="135"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S33 tripeptidyl aminopeptidase-like C-terminal" evidence="6">
        <location>
            <begin position="465"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4038336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="601" mass="66291" checksum="8E9D1CB810936B7D" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PCL2</accession>
    <name>A0AAN6PCL2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Mitochondrial metal transporter 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_37587</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854428">
        <property type="protein sequence ID" value="KAK4038462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PCL2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098771">
        <property type="term" value="P:inorganic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000013">
        <property type="entry name" value="Cation efflux family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1350:FF:000010">
        <property type="entry name" value="Cation efflux family protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="entry name" value="Cation efflux protein, cytoplasmic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050291">
        <property type="entry name" value="CDF_Transporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840">
        <property type="entry name" value="MITOCHONDRIAL METAL TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840:SF15">
        <property type="entry name" value="MITOCHONDRIAL METAL TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="9">
        <location>
            <begin position="44"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="366"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4038462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="397" mass="42527" checksum="37D14075F24D1B1D" modified="2024-10-02" version="1">MGKPQQTRGHAGHGHGHHHHHHHHDNVYLTSTNKNDAGVRITRIGLYSNLGMAIAKGAGGYAFNSQSMIADAWHSLTDLASDVLTLATVSWSLRPPTSSFPQGFGKVESLGSLGVSSMLLIGGLFMCMSSCQSLYAHFFLDAEAARALLEHGHGHSHGHHHGHGHGHGGAPSLHAAWLAAGTVAVKEWLYHATMKVARDRKSSVLASNAVHHRVDSLTGIVALAAILGANLLKDATWLDPVGGLFISLLVIRAGLQNTLSALYELADRSIDDEVRESISKQVGKSLGELVDGRGGEVELRDVTGVKSGQNYLVDLELGVPSLWTVEDVRGVEEAVRTRVGGKVRGVRRVRVRFVPRTAAPVPVDRFDEFIPGDVSPRSSPEPEEENGNGNGKGRKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PCM5</accession>
    <name>A0AAN6PCM5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_37607</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854429">
        <property type="protein sequence ID" value="KAK4038426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PCM5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4038426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="314" mass="35577" checksum="59A53F16EF4658F7" modified="2024-10-02" version="1">MIRNGDIALDSPEAINMPYSISVAAMNVLRFAQVADTPDAPPRFTHKLETPKPDHYFGFHADDWFRAVWAIFFFQKRRRKPIDLPSGQYKLTKPLAICKVSSTDGNRMVKNELTDLSEEAALRKMNNYFATARAQMLTLPLNCDDNLVERLLRRADPKINYLTSLHCSPSLTSKRKESIRTQKARAAQLNELYAEILPLFLPVAEDIMATLRLRIPKATYSSVPAKDVRSFYVSLGDKTASYLENQESLVPAFAEVDKNEDKAAAYNKNMQLLKLAFVTGDLIDTLEVEDIDWEHTLVLLGTNMATVIKAREFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PD38</accession>
    <name>A0AAN6PD38_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_19300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854509">
        <property type="protein sequence ID" value="KAK4033797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PD38"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052391">
        <property type="entry name" value="E3_Ligase-Neurotoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24133">
        <property type="entry name" value="ANKYRIN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24133:SF40">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="302"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="401"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="101"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="341"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4033797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="509" mass="53931" checksum="C88C0B4177186751" modified="2024-10-02" version="1">MAEMTTFSVKHRYWNDALALTSWTIQEEPSNRISWTPHAQARPRRLRKVECREVLKPGQNTLPGIHIHGTACRCTQTQTENQLQDTLLAAKISALSRTLCTTTTSSSTTPRPPPTPYQNNPTRVKRSLSRSRLSPSTTSLLSTLTRLFSPSSPTSTPILPPPSLPLQADLCIGCADLDINKVARYLVPVPRDDTVPLPVNVDAPNHLGMTPLMAAVRSPAAAVRSKAHVEMVRFLVEGCGADVDGVRLDRVTGVGESVLSMACVVGAVEVVRFLVGRGAAAVNARLPSGRGIGSLKGVVVGKGQTALHVAVLADRPECVEVLVGEGKADVDAVFDAAEAEQEPGTGGGFKGLRGRTKSVSWERRGKGPRHPVSALHLAHGSYACTKVLLEAGANVGARDGHGRTPLHWAAEAGNADVVRLLVSAGADTSAASDDGTTALGAVVALLGRPDGKQGRAEVLRVLLGAESRIGRQEAEFVREKLVALQEWCAPMDGAVEDGDVLQEKGVLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PDF1</accession>
    <name>A0AAN6PDF1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_48406</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854446">
        <property type="protein sequence ID" value="KAK4035362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PDF1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37807">
        <property type="entry name" value="OS07G0160300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37807:SF3">
        <property type="entry name" value="OS07G0160300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13671">
        <property type="entry name" value="AAA_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4035362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="176" mass="19536" checksum="EDFE8CDE098ED969" modified="2024-10-02" version="1">MSGTPGAGKSTMAKLLGQPLGAVVIDHDIIKSTVLADGNISFDQAAKSAYSLCWALAESMMKQGFSVIVDNGLRLAELFGFEYWYIECRVDDLDLMDERLQKRVPLRSQRMGVDHPPVDASSCRQGEESRALFRRWIEKPCRPREDDKASVAVVDSTGNPEGRPDYALEQMALQAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PE03</accession>
    <name>A0AAN6PE03_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_38515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854458">
        <property type="protein sequence ID" value="KAK4035003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PE03"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043012597" description="Secreted protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4035003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="115" mass="11821" checksum="70B10019955DE946" modified="2024-10-02" version="1">MKPTGIITTLAVLLMPAPILAAVGGRCSGAYDNGQCICLDHNSCGSYGGHAFEGSAGNYPCPHDAGNIWGCYVDECPGFGSDTACRWNNYCSSSGGSALPNPVCPGGNDFVCCQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PEB4</accession>
    <name>A0AAN6PEB4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Mannose-6-phosphate receptor binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">C8A01DRAFT_49206</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854481">
        <property type="protein sequence ID" value="KAK4034397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PEB4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028927">
        <property type="entry name" value="Man-6-P_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15071:SF0">
        <property type="entry name" value="MANNOSE 6-PHOSPHATE RECEPTOR-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15071">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE RECEPTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02157">
        <property type="entry name" value="Man-6-P_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042829080" evidence="11">
        <location>
            <begin position="24"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="12">
        <location>
            <begin position="38"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="143"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="196"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK4034397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="377" mass="42354" checksum="1342DB40DEA6B173" modified="2024-10-02" version="1">MYPQRSSRGLVLALAALASVSSADEATKTTSTTTSVVTPCVATSTNGAFFDLRPDAAVAVTDGEKPLKGIPTEDYVARGWDYGFNFTLNICNPVVHKVEDVVGVDESLWKNISAYYETKGKIYSLGQSSGELVPRGRKLVLQYKGGSPCGSDKRKDKRANVHEGARYKNHEYEDEDEEYYAATRSKDEEDDEEDDKKDKDKQKEKEKEKEKEKEKEKDREGTRRKSATISFLCDHDPDTSTAFSFVGTGPDECAYFFEVRSQHACAGAEPHKPGSVGPGSVFAIIFFITVLVYVVGGIFYQRTVAHARGWRQLPNYSLWAGIWSFIKDLLIILTSSCARMIPRRRGYHTLSGSPRGRHRDRDDENRLIDQLDEEWDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PEN0</accession>
    <name>A0AAN6PEN0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Aspartic peptidase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_48468</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854448">
        <property type="protein sequence ID" value="KAK4035318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PEN0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05474">
        <property type="entry name" value="SAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033876">
        <property type="entry name" value="SAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF65">
        <property type="entry name" value="ASPARTIC-TYPE ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Peptidase A1" evidence="9">
        <location>
            <begin position="42"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="383"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="392"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="294"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4035318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="663" mass="68016" checksum="EDE80856D0848D8F" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PF06</accession>
    <name>A0AAN6PF06_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 15">Transketolase</fullName>
            <ecNumber evidence="4 15">2.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">C8A01DRAFT_36575</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 15">
            <text>D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:10508"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="15">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <cofactor evidence="15">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="15">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <text evidence="15">Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="12">Binds 1 thiamine pyrophosphate per subunit. During the reaction, the substrate forms a covalent intermediate with the cofactor.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 15">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the transketolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.1" evidence="4 15"/>
    <dbReference type="EMBL" id="MU854400">
        <property type="protein sequence ID" value="KAK4039447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PF06"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004802">
        <property type="term" value="F:transketolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07033">
        <property type="entry name" value="TPP_PYR_DXS_TK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02012">
        <property type="entry name" value="TPP_TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000003">
        <property type="entry name" value="Transketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000003">
        <property type="entry name" value="Transketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000004">
        <property type="entry name" value="Transketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055152">
        <property type="entry name" value="Transketolase-like_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005478">
        <property type="entry name" value="Transketolase_bac-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020826">
        <property type="entry name" value="Transketolase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049557">
        <property type="entry name" value="Transketolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033247">
        <property type="entry name" value="Transketolase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00232">
        <property type="entry name" value="tktlase_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43522">
        <property type="entry name" value="TRANSKETOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43522:SF2">
        <property type="entry name" value="TRANSKETOLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22613">
        <property type="entry name" value="Transketolase_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00801">
        <property type="entry name" value="TRANSKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00802">
        <property type="entry name" value="TRANSKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0106">Calcium</keyword>
    <keyword evidence="7 13 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 13 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12 15" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="16">
        <location>
            <begin position="356"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="418"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="117"/>
            <end position="119"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="359"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="386"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="444"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="468"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="476"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="480"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="527"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="14">
        <location>
            <position position="29"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="14">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAK4039447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="685" mass="74762" checksum="46072A5F21575BF3" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PF99</accession>
    <name>A0AAN6PF99_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD dependent oxidoreductase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_38190</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854447">
        <property type="protein sequence ID" value="KAK4035346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PF99"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03477">
        <property type="entry name" value="Rieske_YhfW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.102.10.10:FF:000014">
        <property type="entry name" value="Oxidoreductase, FAD dependent"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038010">
        <property type="entry name" value="YhfW_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF281">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="6">
        <location>
            <begin position="483"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4035346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="561" mass="61820" checksum="77678F9CED929F6C" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PFF4</accession>
    <name>A0AAN6PFF4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lactonase, 7-bladed beta-propeller-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_16874</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cycloisomerase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854410">
        <property type="protein sequence ID" value="KAK4039118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PFF4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050282">
        <property type="entry name" value="Cycloisomerase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019405">
        <property type="entry name" value="Lactonase_7-beta_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011045">
        <property type="entry name" value="N2O_reductase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344:SF1">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10282">
        <property type="entry name" value="Lactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50974">
        <property type="entry name" value="Nitrous oxide reductase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042847159" evidence="2">
        <location>
            <begin position="21"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4039118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="399" mass="41928" checksum="DA24F732674D8E6D" modified="2024-10-02" version="1">MRTSHSIAVALSAGFRLATAAPVCGGGGASDLLWVTTYPSGEGSGKLLTLKLDQAKLQSAAESETCGPYPSWLTQVDDVLYCVNEAWGGDHGDLASLKINDDLSFTKLSGGQTVGGPVSTIVYGKDGRGLAVADYAGGGIDTFNIADPAAIKLVKSQVYPAPTDGRPEPQNQARPHEAILDPTGDFLVFPDLGADLLRVLRVDKETLEYTDLASHSFARGTGPRHGAFFKSGDKTFLYIVCELSNLLQGFSVAYNADKTLTFTQVYNSTTHGDDKPVPAGTAAAELHIAPGGKFLTVSSRLERSLQYTVANGTAVPSDPLITYSIDAASGALKHVQTAPAGGVNPRHFSFNSDGTRVASALQSDGRVIVFERDIASGKIGKAVAEVDVAGMPNFVMFKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PFW4</accession>
    <name>A0AAN6PFW4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_46618</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854387">
        <property type="protein sequence ID" value="KAK4039962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PFW4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059009">
        <property type="entry name" value="Znf_C2H2_17_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059095">
        <property type="entry name" value="Znf_C2H2_17_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26177">
        <property type="entry name" value="zf_C2H2_17_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26176">
        <property type="entry name" value="zf_C2H2_17_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="363"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="399"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="432"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="475"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4039962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="551" mass="59749" checksum="37DE17BD5014AC32" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PGW0</accession>
    <name>A0AAN6PGW0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Splicing factor Cactin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_37036</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CACTIN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854413">
        <property type="protein sequence ID" value="KAK4038986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PGW0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019134">
        <property type="entry name" value="Cactin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018816">
        <property type="entry name" value="Cactin_central"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21737">
        <property type="entry name" value="POLYGLUTAMINE BINDING PROTEIN 1/MARVEL MEMBRANE-ASSOCIATING DOMAIN CONTAINING 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21737:SF4">
        <property type="entry name" value="SPLICING FACTOR CACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10312">
        <property type="entry name" value="Cactin_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09732">
        <property type="entry name" value="CactinC_cactus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01050">
        <property type="entry name" value="CactinC_cactus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Splicing factor cactin central" evidence="5">
        <location>
            <begin position="58"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Splicing factor Cactin C-terminal" evidence="4">
        <location>
            <begin position="357"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00034534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4038986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="494" mass="56087" checksum="F8CE87DA341954A0" modified="2024-10-02" version="1">MNPDRQAMIDGWKSPRKDSGRDRDITAPRFDSSNRIAKPARPPPAKTNTAVAAGRYLTQDQQSEQFVADEDKFVLKQAKKKADIRVREQRAKPIDYLAFGLRFIDSDRDAFDDDDDDVDIQIPAPEAVLQGLNEAQLRELEEDVRSYHTLEHNARNKEYWTALLSLCADRRQKLKPQGPEGRAVTSVASDVDRILSPKTLEQLEALEKQIKAKLQSNEPIDTDYWEELLKSLLVYKAKAKLKKVCAAIKEARVEMLRARDPERAKALEASDGFSDTVPDLLPGATKAVARLATSATAAQGGSSAPPPGTARFASAGNEDFSQATKALYDREVARGVGEGEEIFAAEEAVPGIQKPLWADKYRPRKPRYFNRVLMGYEWNKYNQTHYDHDNPPPKVVQGYRFNIFYPDLIDKTKAPTFKIIREHGRRKGESFAPAGKEDTCLIRFIAGPPYEDIAFRIVDREWDYSAKKERGFKSSFDKGILQLHFQFKKIYYRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PH43</accession>
    <name>A0AAN6PH43_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF8021 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_17488</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854430">
        <property type="protein sequence ID" value="KAK4038425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PH43"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058334">
        <property type="entry name" value="DUF8021"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26061">
        <property type="entry name" value="DUF8021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042874886" description="DUF8021 domain-containing protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8021" evidence="2">
        <location>
            <begin position="165"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4038425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="269" mass="28641" checksum="902251F1B023B0EC" modified="2024-10-02" version="1">MFSAASSIFLTSLLLLLSNTTPTLAACTRADLLAAASNFVTAVSTGTVTSLPLSTTNFTYQENNKPATLKNTAVFAQPLKIDLSRSTADTVACASYTLIVSASGSNKPYVLATQLRHSAGDDGTSAITLIDTIAATTGSLFFNASKTLGYLRNESWAEITPEAARPGRELLKKVGDAYLDMWTDRTAADSIPWGTDCERVEGSQYTRPCGAQLPRGGSQRNNGNRRYVIDEVVGSVDVLCSFDALGSLPDSHEIRVEGGKVKYVHTVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PHP4</accession>
    <name>A0AAN6PHP4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ca2+ regulator and membrane fusion protein Fig1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_15313</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854368">
        <property type="protein sequence ID" value="KAK4040842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PHP4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000747">
        <property type="term" value="P:conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033481">
        <property type="entry name" value="Dni1/Fig1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28092">
        <property type="entry name" value="FACTOR-INDUCED GENE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28092:SF1">
        <property type="entry name" value="FACTOR-INDUCED GENE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12351">
        <property type="entry name" value="Fig1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4040842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="265" mass="28375" checksum="2B1E0BCFD4EFAB47" modified="2024-10-02" version="1">MVLKHLAKMYFKPAGLLRYAPYLLILPIIVFHALSLTGCVSTSPAIPNIYVVSLRANNNATDTPLQVRIGYFGICGIDEDGTRCQAATGRSVETLAANLFPDLQQGTNNTSSNTTTTPATNSEITDLITTALDLQSRTFISVLAGAAVLFVLGAAALFLFKRDVRSANSWEHPRRSTVIRRVTYGLLFGSTALVFAAALATSQSAGALEYASEGMSHASVLIHAGTTLQVLQWIAFGFEVLFALAVPFLVRYKAVAGEEEGKVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PI46</accession>
    <name>A0AAN6PI46_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Dolichol-phosphate mannosyltransferase subunit 1</fullName>
            <ecNumber evidence="13">2.4.1.83</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">C8A01DRAFT_14855</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a di-trans,poly-cis-dolichyl phosphate + GDP-alpha-D-mannose = a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + GDP</text>
            <dbReference type="Rhea" id="RHEA:21184"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 13">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the dolichol-phosphate mannose (DPM) synthase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 13">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 13">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.83" evidence="13"/>
    <dbReference type="EMBL" id="MU854358">
        <property type="protein sequence ID" value="KAK4041394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PI46"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004582">
        <property type="term" value="F:dolichyl-phosphate beta-D-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006066">
        <property type="term" value="P:alcohol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006720">
        <property type="term" value="P:isoprenoid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035269">
        <property type="term" value="P:protein O-linked glycosylation via mannose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06442">
        <property type="entry name" value="DPM1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000036">
        <property type="entry name" value="Dolichol-phosphate mannosyltransferase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039528">
        <property type="entry name" value="DPM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398:SF1">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0464">Manganese</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="14">
        <location>
            <begin position="14"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK4041394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="245" mass="27024" checksum="A5ADEE3BF16803E2" modified="2024-10-02" version="1">MAPAKPSSGKDSYSVILPTFNERQNLPIITWLLACTFTEHNLDWELVIVDDGSPDGTQDVAKQLIKAYSPHVQLQARSGKLGLGTAYVHGLKFARGNHIVIMDADFSHHPKFIPQMIALQKAHDYDIVTGTRYAGDGGVYGWDLKRKLTSKGANIFADTVLRPGVSDLTGSFRLYKRAVLEKLFESTDARGFTMQMALAVTAKAKGYSIGEVPISFVDRVYGDSKLGGEEIVEYAKGVLQLWWSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PI72</accession>
    <name>A0AAN6PI72_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">type I protein arginine methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.319</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">C8A01DRAFT_35420</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:48096"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11991"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61897"/>
            <dbReference type="EC" id="2.1.1.319"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:48097"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-arginyl-[protein] + S-adenosyl-L-methionine = N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48100"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11990"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65280"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:48101"/>
        </physiologicalReaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.319" evidence="1"/>
    <dbReference type="EMBL" id="MU854374">
        <property type="protein sequence ID" value="KAK4040558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PI72"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035242">
        <property type="term" value="F:protein-arginine omega-N asymmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000003">
        <property type="entry name" value="Blast:Protein arginine N-methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.160.11:FF:000016">
        <property type="entry name" value="Protein arginine methyltransferase RmtB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055135">
        <property type="entry name" value="PRMT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006:SF116">
        <property type="entry name" value="PROTEIN METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22528">
        <property type="entry name" value="PRMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 7 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="10">
        <location>
            <begin position="260"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="Protein arginine N-methyltransferase" evidence="11">
        <location>
            <begin position="363"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="156"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF22528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK4040558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="559" mass="62227" checksum="32ED06F339E6422D" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PII1</accession>
    <name>A0AAN6PII1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_34703</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Cyclase 1 superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854360">
        <property type="protein sequence ID" value="KAK4041292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PII1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34861">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34861:SF10">
        <property type="entry name" value="CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4041292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="336" mass="36925" checksum="D6C11ACF8D1FA07F" modified="2024-10-02" version="1">MDPSSVPDFDDLPKVQGQPQGCAWGVFDKDGKKDVFGTLNFLAPKIVAAAAAEVKDGVSISLNWPLNGIKFPLPGRKPPVHRPHRLRDLGMDCEGWDDELEFNTQFSSQWDSLCHVTTDGTTYNGLKPTQEGLSVQSSAENTLPTIEHWHARGAVAGRGVLIDWKRYHEETTGKPYHPLDGYRITPEDIEKVAKHQGVEFKHGDILIIRTGYTEMLEAPTPEDFAKFQAGTLSGVHGTADTARWVWNHRFAAVAGDAHGFEAIPALKPDGTPGAVSDLVLHPWFLNQFGMPIGELWDLKALSEYTKKTGRYSFLLTSAPLNHPGLVASPPNAIALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PK47</accession>
    <name>A0AAN6PK47_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_44661</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854343">
        <property type="protein sequence ID" value="KAK4042272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PK47"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4042272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="271" mass="28310" checksum="E414C863DE919AB6" modified="2024-10-02" version="1">MAKPTPAARLRRTFHYPSDDDDASSPSPEVLDEQEQESLITTLAHQNETRNKTFHRLLTTLPLLSSLPFLLDLFLGPSTASPRAGPPHLLPLLGLSSLFATGWMLHRLGVTETGFAFLDTTTATTQTASSSSASDKKRLGRRGGYGYGLDTGTGATGSGRTPTRGRWGRRGGQSDGILGSGSASQEGGGGGGKSPLETHLPRLNIALALLALLTGLLQRLRTGPVPTGVSPLLLGALPGVVYAVTVGAKVVMAGVDPERELSALKYGYKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PK75</accession>
    <name>A0AAN6PK75_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PRKR-interacting protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_44683</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854343">
        <property type="protein sequence ID" value="KAK4042302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PK75"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004860">
        <property type="term" value="F:protein kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009548">
        <property type="entry name" value="Prkrip1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13507">
        <property type="entry name" value="PRKR-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13507:SF0">
        <property type="entry name" value="PRKR-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06658">
        <property type="entry name" value="DUF1168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4042302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="229" mass="24890" checksum="19FA1D5DA11079C2" modified="2024-10-02" version="1">MAPRGCVRQLPLSVALAQTSARRPDWLRLNGNGHTAVRQAPMSLALFSNPTQTIPLPPPTTSSTGSSRKPLPPPPEIVTNVQGSSAGAGSGEFHVYKAARRREYERLRQMDEDLAREKEREEFEARRKEREREDEERTRRNRERRGRKRKGKGVSGNNNKEGSTANGMGGGQGEVGKQGVEEGGKEGEGKKAVDEGEEKTEGRTTTDKGGKQAAPVAADGPGLVIHDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PKB6</accession>
    <name>A0AAN6PKB6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine-threonine protein kinase 19-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_13838</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STK19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854339">
        <property type="protein sequence ID" value="KAK4042579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PKB6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046579">
        <property type="term" value="P:positive regulation of Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018865">
        <property type="entry name" value="STK19-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15243">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15243:SF0">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10494">
        <property type="entry name" value="Stk19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="17"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00093458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4042579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="423" mass="43963" checksum="824B977EDF2DD12D" modified="2024-10-02" version="1">MTLRSILGGSRVKKRSSSSTTKRTASPTASSWTASLARTKPGTTTPSKSNNTNNRLQTKLQDHGPATPLLPPSLLHTHLQVPTPLQIHHLILTTMFDPLPPQNSGLGSARTASVLQFRAAVPPVVSVSHFQSLLLAAGVANSPAAAERAMAGLVREGKGRKVVIPTLRAARAGGGELFVLSRELEGLVNRCEGLLGDGVGERFVGWLRGNPGRGRMEEGEGALGRREVDGLVRAGFLTAVNESGTVGGLRARPEERYVRISLETVARAAAGSVAAAGGEGVLHAAGGTGARSMVGPVGAGAGAGTGAGAAAGGFSVAVPGSGVFLKLVSAALEHLADLLRKTQYREMSESDLREKWDGGIVGDSEVALAKKTRGEFTGVMPGRTKKWKEFQGLAFDWVLREAAGAGIVEVFETRSVGRGVRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PL09</accession>
    <name>A0AAN6PL09_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Autophagy-related protein 27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">C8A01DRAFT_33144</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Golgi apparatus membrane</location>
            <topology evidence="4">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Preautophagosomal structure membrane</location>
            <topology evidence="3">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ATG27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854336">
        <property type="protein sequence ID" value="KAK4042752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PL09"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018939">
        <property type="entry name" value="Autophagy-rel_prot_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15071:SF13">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15071">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE RECEPTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09451">
        <property type="entry name" value="ATG27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0072">Autophagy</keyword>
    <keyword evidence="17" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="15 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 20" id="KW-0732">Signal</keyword>
    <keyword evidence="8 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042841076" description="Autophagy-related protein 27" evidence="20">
        <location>
            <begin position="30"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="21">
        <location>
            <begin position="46"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="197"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="206"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAK4042752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="363" mass="40053" checksum="0C641ACE4C39A736" modified="2024-10-02" version="1">MKTPSTWRRWPSALETATLLLSLTPIATATATAAPSTIGTMSSSPLACDAVPVDGGHTYNLRALAGPHVAVTHEYTRPTWHNTTYAVDVCGVLKRKGEVPEGEGCPEGTRVCAIKHRWDPKAGKSAGIDQVIPIVVGDDKGITWEAKRLPGDDTTQKDGKKEGLRLTLQGGTTYQQRAQRTVVEFRCNPDLEGTEGEWESVDEYVPGDKKNARREKKDDDKKDDDKKDGKEDESTPEKQLKKDGAALVWEGYKREKDADGGDMDTLYLTWYTKHACDAAVDEPVAESKHWGVFTWVVILVFLATASYLIFGSWLNYNRYGARGLDLLPHGDTLRDVPYLLRDLVRRALNTLQSTGSRGGYSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PL75</accession>
    <name>A0AAN6PL75_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_34876</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854363">
        <property type="protein sequence ID" value="KAK4041144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PL75"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69322">
        <property type="entry name" value="Tricorn protease domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4041144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="429" mass="47857" checksum="F38562DE2AB0D3EE" modified="2024-10-02" version="1">MARSGIFTFGYNAEFRQDTSSAILEFSKDLLLRMKVYSGKGTADGAAIGKYPVVFVTHSMRGLVVKKAYIIGKSDQQYQAMAGQMSALSRYDDLAVFEWHVKENILRQVPKARAAEMALDRRHLLTYDPPFCNVWDTHALSHPLETYEKRLLPAAQRPNPITSKPRRVVRCLMADNAGRFYCWEGADNGVVMHDISNGQELQQLWAPQFEVGGSLVMAFRVPVKTAQFVFSASEEYLFLSPGGIGGSSKTLTNTVWSLKDSEVICTSDWGSTWEGPWVQRPADDSLLLLLCRTGVRIFEWRALTEVHRTTNANLAQDSAASDSEPLVGAVNFPLDQLDRVDELIEGLSEPGNRLIGRCQGHVVFLDHDYCFCTWDLREGAPSLTLKRHLYLPKDWLDPAMVGLCVVSEHGTLLCPRNGEIGVIQGAIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PLF0</accession>
    <name>A0AAN6PLF0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_44113</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854334">
        <property type="protein sequence ID" value="KAK4042897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PLF0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="157"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="300"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4042897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="338" mass="37534" checksum="306038D9E350B039" modified="2024-10-02" version="1">MNVCPVPDPTSVAYLTGSHLLGSSLDQTAVCPAIPVCHGGPDLTIDFLRGVGAILAFLYRLIRRLGMDLELKDIARFIARSISYIAGTLAIMLKFLSAPVLWVLRACFWPIKAVFSAVFSLVYGILGIVVTPFLVPWYVTVWFWEVAVAVYDELEPLLIYFSFALAIGAVSGVLVVVLTIYIQNLLQYYIPFLRPRRRQRRRARDRHHTTHDDDDDRDREGRRHNTKSHHSHHSHHDHNTSKDKGKGKGRDKDRHPDSAVYWSSSPSPSSSSEEEEAFDHGFHYTLRPGGLTITAATRGSMPPSATASSSSSMAKSSTRRTPPAGVRVGDTIHEESSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PLK6</accession>
    <name>A0AAN6PLK6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Triacylglycerol lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_44799</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854345">
        <property type="protein sequence ID" value="KAK4042148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PLK6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000095">
        <property type="entry name" value="Triglyceride lipase-cholesterol esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11005">
        <property type="entry name" value="LYSOSOMAL ACID LIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="9">
        <location>
            <begin position="132"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="503"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="601"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="526"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="543"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="568"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="605"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4042148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="627" mass="68673" checksum="D04F079CF3E984D6" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PLM4</accession>
    <name>A0AAN6PLM4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Chorismate mutase</fullName>
            <ecNumber evidence="4 13">5.4.99.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">C8A01DRAFT_15057</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>chorismate = prephenate</text>
            <dbReference type="Rhea" id="RHEA:13897"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="EC" id="5.4.99.5"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:13898"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; prephenate biosynthesis; prephenate from chorismate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.5" evidence="4 13"/>
    <dbReference type="EMBL" id="MU854362">
        <property type="protein sequence ID" value="KAK4041161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PLM4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004106">
        <property type="term" value="F:chorismate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046417">
        <property type="term" value="P:chorismate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009094">
        <property type="term" value="P:L-phenylalanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006571">
        <property type="term" value="P:tyrosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.590.10:FF:000002">
        <property type="entry name" value="Chorismate mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.590.10">
        <property type="entry name" value="Chorismate mutase, AroQ class superfamily, eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036263">
        <property type="entry name" value="Chorismate_II_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008238">
        <property type="entry name" value="Chorismate_mutase_AroQ_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037039">
        <property type="entry name" value="CM_AroQ_sf_eucaryotic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002701">
        <property type="entry name" value="CM_II_prokaryot"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01802">
        <property type="entry name" value="CM_pl-yst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21145">
        <property type="entry name" value="CHORISMATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21145:SF12">
        <property type="entry name" value="CHORISMATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01817">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017318">
        <property type="entry name" value="Chor_mut_AroQ_eu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48600">
        <property type="entry name" value="Chorismate mutase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51169">
        <property type="entry name" value="CHORISMATE_MUT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 13" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 13" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-0584">Phenylalanine biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0827">Tyrosine biosynthesis</keyword>
    <feature type="domain" description="Chorismate mutase" evidence="14">
        <location>
            <begin position="146"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR017318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK4041161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="266" mass="30579" checksum="73E0DDEF5358F46B" modified="2024-10-02" version="1">MDSLIDLTESSKALDLSRIRFQLIRLEDTITFHLIERVQFPLNKNIYIPGAVPIPNSSLSFIDWYLMEQERLQSLIRRYESPDECPFFPEAVQKPILDSLAYPRILYPNDVNVNDKIKKFYIEKFLPNVCPDFGRDDRGVSQENYGSSATCDIACLQALSRRIHYGKFVAESKFQSEADKFTRLIRAGDRRAIGDAITNKAVEKKVLERLKLKAQTYGTDPSLGPDGWDQGKINVDAVVSMYEDFVIPLTKEVEVEYLMQRLEPVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PLP3</accession>
    <name>A0AAN6PLP3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">polynucleotide adenylyltransferase</fullName>
            <ecNumber evidence="5">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">C8A01DRAFT_32479</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DNA polymerase type-B-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="5"/>
    <dbReference type="EMBL" id="MU854328">
        <property type="protein sequence ID" value="KAK4043353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PLP3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050265">
        <property type="term" value="F:RNA uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010605">
        <property type="term" value="P:negative regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002058">
        <property type="entry name" value="PAP_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271">
        <property type="entry name" value="POLY A POLYMERASE CID PAP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271:SF40">
        <property type="entry name" value="POLY(A) RNA POLYMERASE GLD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03828">
        <property type="entry name" value="PAP_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="12">
        <location>
            <begin position="244"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="PAP-associated" evidence="11">
        <location>
            <begin position="876"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="936"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1056"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1098"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="20"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="116"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="949"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="1056"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="1111"/>
            <end position="1121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK4043353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1121" mass="123343" checksum="E4C9D67879FB4656" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PLU9</accession>
    <name>A0AAN6PLU9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_43571</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854327">
        <property type="protein sequence ID" value="KAK4043443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PLU9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018811">
        <property type="entry name" value="MRX11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28002">
        <property type="entry name" value="MIOREX COMPLEX COMPONENT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28002:SF1">
        <property type="entry name" value="MIOREX COMPLEX COMPONENT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10306">
        <property type="entry name" value="FLILHELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4043443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="235" mass="25948" checksum="5F62748779BC06AC" modified="2024-10-02" version="1">MRPLQPPGAIARLFHPPAPRRAPRPQQASTPRSRPQRSYSTTPTPTPPNTAPKVNPDKNASTRLDRLLARLPRPLQRYTSRLRGAPVTHVAAFLILHELTAVVPLLGLFGVFHYTEYVPVAWMVAHYGGYVREGVGRFERWFTRRGWFGFGPSGSSSSEGDGESGVIEGQGQGVVGAEAALQRWEADPKYRVLVEVGLAYALTKVLLPVRIVGSVWATPWFAGVLGRLRRVVRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PM01</accession>
    <name>A0AAN6PM01_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Eukaryotic translation initiation factor 3 subunit A</fullName>
            <shortName evidence="7">eIF3a</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Eukaryotic translation initiation factor 3 110 kDa subunit homolog</fullName>
            <shortName evidence="7">eIF3 p110</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Translation initiation factor eIF3, p110 subunit homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">TIF32</name>
        <name evidence="10" type="ORF">C8A01DRAFT_32731</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the eIF-3 subunit A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854330">
        <property type="protein sequence ID" value="KAK4043242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PM01"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071540">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3e"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043614">
        <property type="term" value="C:multi-eIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002188">
        <property type="term" value="P:translation reinitiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.860:FF:000003">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.10:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.860">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.10">
        <property type="entry name" value="UVR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03000">
        <property type="entry name" value="eIF3a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027512">
        <property type="entry name" value="EIF3A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054711">
        <property type="entry name" value="eIF3a_PCI_TPR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14005:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14005">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3, THETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22591">
        <property type="entry name" value="eIF3a_PCI_TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="PCI" evidence="9">
        <location>
            <begin position="339"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="822"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="611"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="702"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="822"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="916"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="945"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="977"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="1009"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1028"/>
            <end position="1044"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4043242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1070" mass="121264" checksum="42651D9EF6DE31E2" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PME2</accession>
    <name>A0AAN6PME2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Putative phospholipase</fullName>
            <ecNumber evidence="4">3.1.1.47</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_32378</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17777"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30909"/>
            <dbReference type="ChEBI" id="CHEBI:36707"/>
            <dbReference type="EC" id="3.1.1.47"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the serine esterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.47" evidence="4"/>
    <dbReference type="EMBL" id="MU854327">
        <property type="protein sequence ID" value="KAK4043452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PME2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003847">
        <property type="term" value="F:1-alkyl-2-acetylglycerophosphocholine esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016715">
        <property type="entry name" value="PAF_acetylhydro_eukaryote"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10272:SF7">
        <property type="entry name" value="PHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10272">
        <property type="entry name" value="PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03403">
        <property type="entry name" value="PAF-AH_p_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018169">
        <property type="entry name" value="PAF_acetylhydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3 4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="397"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="579"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="407"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="420"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="431"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR018169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4043452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="629" mass="68261" checksum="89626D831733D5B8" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PMH0</accession>
    <name>A0AAN6PMH0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Biotrophy-associated secreted protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_34069</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854350">
        <property type="protein sequence ID" value="KAK4041819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PMH0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042964094" description="Biotrophy-associated secreted protein 2" evidence="2">
        <location>
            <begin position="21"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="121"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4041819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="232" mass="21897" checksum="59DA83435A3116ED" modified="2024-10-02" version="1">MVQLSAFVGALALIISAVHAAPDLSARQSIPDPAGEKNVGNGAGVQFIGGQCLGAADCASGCCATLPKGGQTIGVCSGVGAQNQAGKQGCGFESGGAGGAGNQGGNQGGSQEDTQGGNQGGNQNNAGGNQNNAGGNQNNAGGNQNNGQAGGTIKPSGLKPDPAGAANVGNAQGKQFITGECTSDADCASGCCALVNTGQAKFGVCSGPAANTQNGKQGCGFPAGGQRISGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PMZ4</accession>
    <name>A0AAN6PMZ4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CBM1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_14833</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854357">
        <property type="protein sequence ID" value="KAK4041455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PMZ4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048955">
        <property type="entry name" value="Cip1-like_core"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21340">
        <property type="entry name" value="Polysacc_lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042944965" description="CBM1 domain-containing protein" evidence="5">
        <location>
            <begin position="20"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="6">
        <location>
            <begin position="279"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="238"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="239"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4041455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="315" mass="32786" checksum="5586A1754D8972FD" modified="2024-10-02" version="1">MFREAALLAFAALPALSSAQISNDFESGWDQTAWPIYAPDCNQGGKVSLDSSTAHSGKNSIRVDGAGGYCGHIFFGTNQVPSGDLYVRAYLKASKALTSSHVSFITMPDPAQGTNKHLRIGGQSEILMYNRESDDATLPELSPQGIATSAALPTGSWECFEYHVGTDGTIETWLNGAAVAGLTVGPAISNPNAGAWSRSTIKPKPSGVYFGWESYGGDTNTFWYDDIVISSSRVGCSGGSTSPSPTGAGPSTTLVTSTTKASSSTTSAAPATSSTSSGCTSPQWSQCGGINYKGCTTCAAPYTCKVSNEYYSQCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PNK2</accession>
    <name>A0AAN6PNK2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Diphthine--ammonia ligase</fullName>
            <ecNumber evidence="1">6.3.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Diphthamide synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Diphthamide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_14254</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>diphthine-[translation elongation factor 2] + NH4(+) + ATP = diphthamide-[translation elongation factor 2] + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19753"/>
            <dbReference type="Rhea" id="RHEA-COMP:10172"/>
            <dbReference type="Rhea" id="RHEA-COMP:10174"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16692"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:82696"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.1.14"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.14" evidence="1"/>
    <dbReference type="EMBL" id="MU854346">
        <property type="protein sequence ID" value="KAK4042121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PNK2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017178">
        <property type="term" value="F:diphthine-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01994">
        <property type="entry name" value="AANH_PF0828-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06155">
        <property type="entry name" value="eu_AANH_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1490.10:FF:000004">
        <property type="entry name" value="ATP binding L-PSP endoribonuclease family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1490.10">
        <property type="entry name" value="putative n-type atp pyrophosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002761">
        <property type="entry name" value="Diphthami_syn_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030662">
        <property type="entry name" value="DPH6/MJ0570"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12196:SF2">
        <property type="entry name" value="DIPHTHINE--AMMONIA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12196">
        <property type="entry name" value="DOMAIN OF UNKNOWN FUNCTION 71 DUF71 -CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01902">
        <property type="entry name" value="Diphthami_syn_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Diphthamide synthase" evidence="7">
        <location>
            <begin position="219"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="74"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="173"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="420"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="694"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="179"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="203"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="701"/>
            <end position="713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4042121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="912" mass="94767" checksum="D18E7C479AEE5F8D" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PNK8</accession>
    <name>A0AAN6PNK8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATP-NAD kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_44553</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854341">
        <property type="protein sequence ID" value="KAK4042419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PNK8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.30:FF:000005">
        <property type="entry name" value="NAD+ kinase Utr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10330:FF:000025">
        <property type="entry name" value="NAD+ kinase Utr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00361">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275:SF0">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20143">
        <property type="entry name" value="NAD_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="86"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4042419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="649" mass="70406" checksum="7D1EE5A393A2C3DC" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PP40</accession>
    <name>A0AAN6PP40_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein mL44</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">C8A01DRAFT_43728</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ribonuclease III family. Mitochondrion-specific ribosomal protein mL44 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854328">
        <property type="protein sequence ID" value="KAK4043423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PP40"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19873">
        <property type="entry name" value="DSRM_MRPL3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044443">
        <property type="entry name" value="Ribosomal_mL44_DSRM_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044444">
        <property type="entry name" value="Ribosomal_mL44_DSRM_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207:SF32">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207">
        <property type="entry name" value="RIBONUCLEASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22892">
        <property type="entry name" value="DSRM_MRPL44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RNase III" evidence="11">
        <location>
            <begin position="99"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="10">
        <location>
            <begin position="322"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="45"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK4043423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="426" mass="46563" checksum="7A2A5F70437A329F" modified="2024-10-02" version="1">MKRLRLDRWTGQLLLARPGASPASTPRAALRAAAAVPSRCAAVRSQSTGAAVPQIPREDVDDYYDGTDHTRFPPLEPLPPRATSLPSPPPERALQSAKLAALHARLSLPERLPLQTLARALVDASADENPQFNNTTLAFVGQSLINYHVAEWVMCRYPRLPMDIMYATMKGYAGASSLHHVARAWGVEHAAAPGGEVDPGLLQFSLHKPGDAIVGLGYRRAEADGMKKYKWRHGMSSRVVFDDDFGEVVDTEDAKDELRLRRDTEYGNEYTRALAEKAFATCARAVTGAIYAHAGRDAAKAFVQAHVLSRTLDLSKLFAFAKPTRELSMLCAREDFEPPVARLLSETGRMSRTPVFVVGIFSGKDKLGEAAGPSLEVARNKAAMNALKSWYLYSPGEGVRVPSDMLADDARPWEPAYIDIGEVVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PPB0</accession>
    <name>A0AAN6PPB0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_31275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854318">
        <property type="protein sequence ID" value="KAK4044492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PPB0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
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        </location>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK4044492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="959" mass="104261" checksum="1B3CE5E9E9F40720" modified="2024-10-02" version="1"> </sequence>
</entry>
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    <accession>A0AAN6PPF9</accession>
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        </submittedName>
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        <name evidence="2" type="ORF">C8A01DRAFT_42378</name>
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        <name type="scientific">Parachaetomium inaequale</name>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854316">
        <property type="protein sequence ID" value="KAK4044756.1"/>
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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            <end position="532"/>
        </location>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="KAK4044756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="924" mass="103655" checksum="0AEE5CFC3C0404CA" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
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    </dbReference>
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        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000156">
        <property type="entry name" value="Ran_bind_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045255">
        <property type="entry name" value="RanBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045256">
        <property type="entry name" value="RanBP1_RanBD"/>
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    <dbReference type="PANTHER" id="PTHR23138:SF87">
        <property type="entry name" value="E3 SUMO-PROTEIN LIGASE RANBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138">
        <property type="entry name" value="RAN BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RANBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="94"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        <location>
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    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50196"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK4044657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="256" mass="28381" checksum="5732A4F074ADF209" modified="2024-10-02" version="1">MSAENENKPLEEVKAPETPAPEAAAAAEAKPMATTSSVFSMFGGGAKKEKKDEDEDRGDNSGSAKAQREAAAAAAAASKEGGEEEEAPESEDVHFEPVIHLTEKVETKTNEEMEEQVFKMRAKLFKYVSESREWKERGTGDVRLLKHRDNGKTRLVMRRDKTLKVCANHYVVPEMKLSPNVGSDRSWVWNVVADVSEGEPEALTLAIRFANSDNANQFKDAFIKAQKENETLFKNAEAGGEEKEDTKEEEKKEETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PQK1</accession>
    <name>A0AAN6PQK1_9PEZI</name>
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        <recommendedName>
            <fullName evidence="9">Small nuclear ribonucleoprotein Sm D3</fullName>
            <shortName evidence="9">Sm-D3</shortName>
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            <fullName evidence="9">snRNP core protein D3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">C8A01DRAFT_32380</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the snRNP core protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854327">
        <property type="protein sequence ID" value="KAK4043454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PQK1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Small nuclear ribonucleoprotein Sm D3"/>
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    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
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        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034099">
        <property type="entry name" value="SmD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23338">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Sm-like ribonucleoproteins"/>
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    </dbReference>
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        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="7"/>
            <end position="79"/>
        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008146"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU365050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK4043454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="110" mass="12087" checksum="A0306431F4900D88" modified="2024-10-02" version="1">MTSTIGIPIKLLNEAQGHIVTLEITSGQTYRGKLIEAEDNMNVQLKDITVTARDGRVSHLEQVYIRGSHVRFFIVNAPMFRSRNVRGRGVGLARGRATVSRARAGGRGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PQR2</accession>
    <name>A0AAN6PQR2_9PEZI</name>
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        <recommendedName>
            <fullName evidence="3">CID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_42920</name>
    </gene>
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        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ENTH_VHS"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR035967">
        <property type="entry name" value="SWAP/Surp_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23140">
        <property type="entry name" value="RNA PROCESSING PROTEIN LD23810P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23140:SF0">
        <property type="entry name" value="U2 SNRNP-ASSOCIATED SURP MOTIF-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01805">
        <property type="entry name" value="Surp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109905">
        <property type="entry name" value="Surp module (SWAP domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
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        <location>
            <begin position="473"/>
            <end position="666"/>
        </location>
    </feature>
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        <location>
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            <end position="37"/>
        </location>
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        </location>
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        </location>
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        </location>
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        <location>
            <begin position="746"/>
            <end position="825"/>
        </location>
    </feature>
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            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
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        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
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        <location>
            <begin position="127"/>
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        </location>
    </feature>
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        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="541"/>
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        </location>
    </feature>
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        <location>
            <begin position="746"/>
            <end position="759"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4044248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="825" mass="89713" checksum="9EE363F54BA0F027" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PQU1</accession>
    <name>A0AAN6PQU1_9PEZI</name>
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        <recommendedName>
            <fullName evidence="2">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_13178</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854329">
        <property type="protein sequence ID" value="KAK4043276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PQU1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="198"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4043276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="350" mass="36518" checksum="1079B875149D1205" modified="2024-10-02" version="1">MVANGKNSGKAPDLEKMIHDARDRKKNEALAAKIFSRDRRSSPAASKTSAAGSLASRAGVKKRAEPTNRPRHSTGNIDGEWTHDLHETQTRGPKANGKASGSGAGSLAARITNPNAPPTGPASHRRQTRRAAQVQALVESGQVDPLNSHEAQLLLMQQQAARDKATNGTIPTGPRAMTKAASTFNQGITIRGLAGPFVVMAQNFAPGTTAADIESAMTPVGGIVTSCRVVKQHPLVIAEIVFESKEGADNVIATFNNQTADGRVLNVYPKVGNTPSTPSAQAPTRPSSDNDMVVDGSYGFDEPADAASGTGRQPPTGPAAGVGGGLYSDNLVKTNRWGRGFSRAGRFGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PQW8</accession>
    <name>A0AAN6PQW8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_13455</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854333">
        <property type="protein sequence ID" value="KAK4042955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PQW8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4042955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="359" mass="40732" checksum="82FB484AB3E3494E" modified="2024-10-02" version="1">MPPTKPTKPKSRLTPSPKPTTPSSPPHPFTPAPPSLTPFCATLPRGHVYITHVDPRPAAFKRKLFLVPVALNLAVIALFLWRMWYIAPYYAALLTSGLGYPNETTLRAADLSYAELGRVVLRRAATFLLDFVLGVFVWPWPWEFFVGTTGRESPIFWRWRVGFRGQEVYVRRSRESWDGVLREEGVDLFDEEARAAREGRDGILARVRAATSPMLMQQKTGYLTMDGEWDLDWRGMVDATRLADKKEVALEAFGTVVLLHHGKFGWVSVDLGKGENVEQDERRRQVMLFKDALSTLGKEDLFFRWVEMIQFETTQPGGFTHEKQVAAAQKIRDLFKSNGVDFDELWKETVGTDGLAGMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PQX4</accession>
    <name>A0AAN6PQX4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_43391</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854325">
        <property type="protein sequence ID" value="KAK4043634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PQX4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18026">
        <property type="entry name" value="DEXHc_POLQ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.20:FF:000005">
        <property type="entry name" value="DNA-directed DNA polymerase theta, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057220">
        <property type="entry name" value="DUF7898"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050474">
        <property type="entry name" value="Hel308_SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046931">
        <property type="entry name" value="HTH_61"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048960">
        <property type="entry name" value="POLQ-like_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961">
        <property type="entry name" value="DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961:SF6">
        <property type="entry name" value="DNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25453">
        <property type="entry name" value="DUF7898"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20470">
        <property type="entry name" value="HTH_61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21099">
        <property type="entry name" value="POLQ_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="154"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="408"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="34"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4043634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="938" mass="103859" checksum="4123EE869FBAC726" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PR99</accession>
    <name>A0AAN6PR99_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein-serine/threonine kinase</fullName>
            <ecNumber evidence="7">2.7.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_30971</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the PDK/BCKDK protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="7"/>
    <dbReference type="EMBL" id="MU854316">
        <property type="protein sequence ID" value="KAK4044790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PR99"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004740">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010906">
        <property type="term" value="P:regulation of glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.20">
        <property type="entry name" value="Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036784">
        <property type="entry name" value="AK/P_DHK_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018955">
        <property type="entry name" value="BCDHK/PDK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039028">
        <property type="entry name" value="BCKD/PDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947:SF25">
        <property type="entry name" value="[PYRUVATE DEHYDROGENASE (ACETYL-TRANSFERRING)] KINASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10436">
        <property type="entry name" value="BCDHK_Adom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69012">
        <property type="entry name" value="alpha-ketoacid dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase N-terminal" evidence="9">
        <location>
            <begin position="28"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="345"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="351"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4044790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="448" mass="50453" checksum="3C0F6846C3D8FB97" modified="2024-10-02" version="1">MARYSHAHSPKWRPVSVLDEWVAREARPISLRQLMVFGRSLTESRLISSANYVRTELPTRIAHRIRDMQQLPYVVVTNPHVNEVYDLYYTAFDTFRKVKDIKTLEDNDRFCKTIRSMLKAHLTVIPKLAMGILESNGLMDSAALDKFMNTILRSRISRRVIAEQHLALTDTFHAPWFSPGAKLSESEFIGQVFLKCVAKDVVSRCGSAVREILQRAYGPDVALPEIRIDGHLDANFPYILSHLEYIIGELLRNSVQAVAEKHQRRCKDNKDKDTPQPPPPPPIEVTICESHQHVIIRISDQGGGIPRESLPYLWSFSKGPASGKILANLGKVPKMAATMQELQVEEDDDHDHDHTHNRDHASHENRSTSLEDGEIGRDVNSSLASLSSRPPNLRLGMGLPLSRVYAEYWAGSLALHSLEGYGVDAFLQISKLGNKNEQLTTRASMDAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PRA9</accession>
    <name>A0AAN6PRA9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Multiple myeloma tumor-associated protein 2-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_30988</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854316">
        <property type="protein sequence ID" value="KAK4044805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PRA9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019315">
        <property type="entry name" value="MMTA2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039207">
        <property type="entry name" value="MMTAG2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14580:SF0">
        <property type="entry name" value="MULTIPLE MYELOMA TUMOR-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14580">
        <property type="entry name" value="MULTIPLE MYELOMA TUMOR-ASSOCIATED PROTEIN 2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10159">
        <property type="entry name" value="MMtag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Multiple myeloma tumor-associated protein 2-like N-terminal" evidence="2">
        <location>
            <begin position="11"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4044805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="142" mass="15760" checksum="03A2D4FA36C4EB31" modified="2024-10-02" version="1">MDLLSTVRKTGSRGGVNFSWDDVATSQYRENYLGHSLKAPVGRWAKGRDLNWYAKADASAADSNETEEERAARERRDEIRQIKEAEEDAISRALGLPIKPRDATGANAVEVEASKVPSRDTGDDKKSKEKKASEQRPRSGQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PRB2</accession>
    <name>A0AAN6PRB2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">E3 ubiquitin-protein ligase RBX1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">C8A01DRAFT_32670</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854330">
        <property type="protein sequence ID" value="KAK4043180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PRB2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16485">
        <property type="entry name" value="mRING-H2-C3H2C2D_RBX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000010">
        <property type="entry name" value="E3 ubiquitin-protein ligase RBX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051031">
        <property type="entry name" value="RING-box_E3_Ubiquitin_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024766">
        <property type="entry name" value="Znf_RING_H2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11210">
        <property type="entry name" value="RING BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12678">
        <property type="entry name" value="zf-rbx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="64"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK4043180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="119" mass="13502" checksum="D8AA72F89657E942" modified="2024-10-02" version="1">MADVEMTDAPTSAPVTKKKGGAEGEGKEGKKRFEVKKWNAVALWAWDIVVDNCAICRNHIMDLCIECQANQASATSEECTVAWGICNHAFHFHCISRWLKARQVCPLDNRDWEFQKYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PSR1</accession>
    <name>A0AAN6PSR1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_31983</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854323">
        <property type="protein sequence ID" value="KAK4043885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PSR1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4043885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="368" mass="41974" checksum="1670A67CC3F2D649" modified="2024-10-02" version="1">MSNFEIPEPTANLKALAKRHPVDYQRLYQFFWDAFDDFEVPTVNDPSFAKAGGQSQDAIDMVIGEEEEALFSAIPSLYYYSQREAALPDASILALEKESPKVLSSLRDYFVARIGDDYLWEEFDAPDYMSLTDQERADIDDFVREVQNPRRIKRNKGERLKPHESLLLTEQAKDLQVLRSILLKLSAPEPQWVGIMRHVAVEAARALKKQRRRKQPSPSRIERLVEALFDPEEWASSDAHTESLNISEVSQQLAAPVFFSGPEASGLDRREGLFYRTLDISASLPKTEYRDFIERIGRRELFDLLKSSVDASVWDNILGGGRTADKQYLHSLQEDDNSLKTAGWYLAVGMDPADVEFIKKSSHMLKHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PTV8</accession>
    <name>A0AAN6PTV8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_31267</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854318">
        <property type="protein sequence ID" value="KAK4044485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PTV8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37451">
        <property type="entry name" value="MARVEL DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37451:SF4">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="7">
        <location>
            <begin position="22"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="207"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="207"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="227"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="252"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="289"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="306"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4044485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="334" mass="36241" checksum="5AA0839ACC26F84E" modified="2024-10-02" version="1">MNNPQYRAPGREHIPLLPKGFFAIRIVQLVLALIIMGLAGYGVSVLPFSGNCYILAVAVMTLATSIYQLVAELGPPAAYNYWATLGLDIFYVVMWLCSFAVLAASVAPWFGYSSYSYSYSYSRYSSSSLSDYTLIWLATQAAAASLGALEFILYLTSLIIHSVRLHRHRAAGLHCMPGTPPGPRPPAGTTVVPVPVVYTTGNKPGGPLPVYPQFPPQQPVPAYLHGQQPQQVPPQQQQQFYPPQGYAPVPIPMQGMPMQQMPMPPQQQPQQGFYAPPVQMQQQQQPQQMQPPQPTGSPAPQPIVPQATGGSFAASSQGGQQVPQQQQVSQLPAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SLD3</accession>
    <name>A0AAN6SLD3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_21218</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854753">
        <property type="protein sequence ID" value="KAK4031587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SLD3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF33">
        <property type="entry name" value="KYNURENINE FORMAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4031587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="238" mass="25056" checksum="8169855FA0FCF650" modified="2024-10-02" version="1" fragment="single">MQSDGDAEVDRRVWASVPWSAVSDPGTGTGADTPIGWHKSGIPYPTPGAEAVPLPLQTLDVWIPASTPNNTATPPDPSSLPHPLPGSTWIVYIHGGAWRDPRISAASFTAAATALLLQNTTTPKHNLAGLISLNYRLSPHPSHPSPSDPSRQAKHPDHIADVHAALAFLHRLPILNTDNWILTGHSCGATLAFQAVMDPARWGGLPPSSVSFSPSALVGFNGLYDLAGFIASPPEGYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SLN1</accession>
    <name>A0AAN6SLN1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-dependent RNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_40603</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RdRP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.48" evidence="1"/>
    <dbReference type="EMBL" id="MU854562">
        <property type="protein sequence ID" value="KAK4032951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.790">
        <property type="entry name" value="RNA-dependent RNA polymerase, slab domain, helical subdomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007855">
        <property type="entry name" value="RDRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057596">
        <property type="entry name" value="RDRP_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079:SF14">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05183">
        <property type="entry name" value="RdRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0696">RNA-directed RNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RDRP core" evidence="4">
        <location>
            <begin position="477"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="147"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1344"/>
            <end position="1368"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1174"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="110"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="182"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="246"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="313"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1353"/>
            <end position="1368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4032951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1368" mass="152977" checksum="55CE34A91D29FB62" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SMB3</accession>
    <name>A0AAN6SMB3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">UDP-galactose transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_49784</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854516">
        <property type="protein sequence ID" value="KAK4033671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SMB3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015165">
        <property type="term" value="F:pyrimidine nucleotide-sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007271">
        <property type="entry name" value="Nuc_sug_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00803">
        <property type="entry name" value="nst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10231">
        <property type="entry name" value="NUCLEOTIDE-SUGAR TRANSMEMBRANE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04142">
        <property type="entry name" value="Nuc_sug_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005799">
        <property type="entry name" value="UDP-gal_transpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="154"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="294"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="323"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="346"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4033671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="402" mass="42825" checksum="5F9C7BFB783E44D6" modified="2024-10-02" version="1">MPASKSHGDSGRAAAGDAAAAVAAVQLLQAPFRRCLSVQRLSLALLVLQNSILVMVMHHSRNSPTGTQPRYLASTAVLLVEVVKLLASLVLAAHDTRRSHPGASTSTLIVHLRHSIFAPDSWKLIVPAALYTLQNSLVYAAISNLDAVTFQVTYQLKILTTVLFSILLLGRSVSPRQWLSLVLLTAGVALVQISGPITPDDWLERLTSLLRSGTIPTTNAAKGLMAVVAASLTSGLTCVYFEKLVKDSMASVSLWTRNVQLSFFSLFPALFIGVLWQDGAVIARVGFFAGYSPVVWLTIGLQALGGLIVAVCIAYADNVAKNFAASLSIVVSYAATAFIFGTPPTLHATAGAAVVLLAMFLFNSRPTSRAMVLPLSQERYVAEKSRPLLTELTSVSNTEQGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SML3</accession>
    <name>A0AAN6SML3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">C8A01DRAFT_20169</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854573">
        <property type="protein sequence ID" value="KAK4032818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SML3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03213">
        <property type="entry name" value="ABCG_EPDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000702">
        <property type="entry name" value="ABC transporter (Adp1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF2">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0732">Signal</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042836916" description="ABC transporter domain-containing protein" evidence="14">
        <location>
            <begin position="23"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="316"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="824"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="857"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="900"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="937"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="967"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="998"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1027"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1056"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="15">
        <location>
            <begin position="369"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="660"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="660"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="681"/>
            <end position="694"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK4032818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1079" mass="117838" checksum="7326FED60341BB28" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SN04</accession>
    <name>A0AAN6SN04_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_19428</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854517">
        <property type="protein sequence ID" value="KAK4033659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SN04"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4033659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="70" mass="8666" checksum="85155A50D8101578" modified="2024-10-02" version="1">MCDYTQREYSCGHFRWIASKWCRDYTMTHKRCQPNVTHFEYRAEELCGECKPKEYPPWENLIKRPKQPTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SP18</accession>
    <name>A0AAN6SP18_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Peptidase S8/S53 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_39133</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854481">
        <property type="protein sequence ID" value="KAK4034407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SP18"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04842">
        <property type="entry name" value="Peptidases_S8_Kp43_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051048">
        <property type="entry name" value="Peptidase_S8/S53_subtilisin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034058">
        <property type="entry name" value="TagA/B/C/D_pept_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43399:SF4">
        <property type="entry name" value="CELL WALL-ASSOCIATED PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43399">
        <property type="entry name" value="SUBTILISIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S8/S53" evidence="7">
        <location>
            <begin position="199"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="393"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="393"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4034407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="663" mass="71019" checksum="22D4EE22A8B9406E" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SP78</accession>
    <name>A0AAN6SP78_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein acetyllysine N-acetyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.286</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_38906</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the sirtuin family. Class IV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.286" evidence="2"/>
    <dbReference type="EMBL" id="MU854471">
        <property type="protein sequence ID" value="KAK4034647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SP78"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000038">
        <property type="entry name" value="NAD-dependent protein deacetylase sirtuin-6 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF12">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="9">
        <location>
            <begin position="17"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4034647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="394" mass="43311" checksum="7FE20E8BDA815AF0" modified="2024-10-02" version="1">MAWTADKLPLPELVETSDELDQKATQLAGLIRQSKHFIVFTGAGISTSAGIPDFRGPEGAWTLQAQGRQRTTGVTSTLQAIPTATHMALVELQNRGLLKYLVSQNCDGLHRRSGILPDKISELHGNNNREICKDCGKEYIRDFRAVADYTKSVHDHRTGRKCTRCGGVLHDTIINFTESLPERELQLAYDHAKRADLCLVLGSSLTVTPANEIPEVVGNRRRRGAKLVICNLQATPLDGMAELRVHAKTDELMVGVMRELGMETPGFVLQRRLAATVEVAGQGRGQRCKVTVAGVDVDGTPVSFLRAVKLVNNRRVLKAEPFVFDLRGDVADGGLELELELDFMGHYGEPNLQLVHGVQEKDIGVAAVYLLEYNPYNGEWRTTRQLGTPGVAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SPZ5</accession>
    <name>A0AAN6SPZ5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">DNA mismatch repair protein msh-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">C8A01DRAFT_37773</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the post-replicative DNA mismatch repair system (MMR).</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterodimer of msh2 and msh6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854433">
        <property type="protein sequence ID" value="KAK4038317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SPZ5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032301">
        <property type="term" value="C:MutSalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03285">
        <property type="entry name" value="ABC_MSH2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.110:FF:000002">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.10:FF:000003">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000523">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1420.10:FF:000015">
        <property type="entry name" value="DNA mismatch repair protein Msh2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1420.10:FF:000017">
        <property type="entry name" value="DNA mismatch repair protein Msh2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011184">
        <property type="entry name" value="DNA_mismatch_repair_Msh2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032642">
        <property type="entry name" value="Msh2_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003810">
        <property type="entry name" value="PRK05399.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF35">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005813">
        <property type="entry name" value="MSH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="11">
        <location>
            <begin position="733"/>
            <end position="749"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00064337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK4038317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="940" mass="105248" checksum="D9AB40A39C791202" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SQ35</accession>
    <name>A0AAN6SQ35_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Mitochondrial carrier protein MTM1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">C8A01DRAFT_38123</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854445">
        <property type="protein sequence ID" value="KAK4035385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SQ35"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990542">
        <property type="term" value="P:mitochondrial transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045315">
        <property type="entry name" value="Mtm1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45760">
        <property type="entry name" value="FI19922P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45760:SF2">
        <property type="entry name" value="FI19922P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="36"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="208"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="350"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="312"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="379"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="472"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="318"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="390"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="477"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK4035385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="491" mass="52688" checksum="8D3AFBBDF3F10E87" modified="2024-10-02" version="1">MAPFATSTHAHGAGQNHDIIPDHGAPADPPSDPVEITAVQKMLSATSGSLLTGLLATPLDVVRVRWQSQGIAPPPAIDFTKLAMPTTPGGATFRPSNNLGVTACCREVFFTNNTSEVCVVRPPQPLPTTTTNTNTTPQITCAVEQTQQRTFTSTFDGLRKIARNEGVTTLWRGLSPTLIMAIPANIIYFTGYEWLRFNKASPIARAFADDYAPLVAGSVARVLAATAVSPIELFRTRLQAVQGSTSTGGRGGHLASTFRGITDMVAAHGYRALWRGLTLTLWRDVPFSGMYWWGYETIRGRLSDARERAREAGAGGLDLEREERGRGDAAARDGRARRRSRSRSRENHADTFTDSFIAGAASGGFASVVTMPFDVGKTRTQVFRDPPPSSSSSSSAASAAARSAEHAAAAPEERNMARLLWHIFRTEGLPGLFRGCVPRTLRVAPACAIMISSYEVGKRVFRGVNERALAERRGLSTETGTATATATAAEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SQB6</accession>
    <name>A0AAN6SQB6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallo-dependent phosphatase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_17645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854435">
        <property type="protein sequence ID" value="KAK4038241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SQB6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07379">
        <property type="entry name" value="MPP_239FB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051693">
        <property type="entry name" value="UPF0046_metallophosphoest"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905:SF18">
        <property type="entry name" value="ESTER HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G03130)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905">
        <property type="entry name" value="METALLOPHOSPHOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="1">
        <location>
            <begin position="63"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4038241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="331" mass="37063" checksum="3F64423B3AD64BEA" modified="2024-10-02" version="1">MLTPLNNLLLTLHLRRASPWSPPTPLDWLLASPLQWLTSLLYRHVLLPLRGTPFHPPRGRRPIRVVVLSDTHNLVPDYRVPEGDLLIHCGDLTVDGTVGEIQAQVDWLRGLGHTWKVVVGGNHDGWVDEGVRKEMGEKGEGEVDWTGVEYLCDHGVELEFEGGRRLNVWGFGAVPWCGEGFALQYEREKHPWKGRVPEETDVLVTHTPPRHHLDLGLGCSGLLDEIWRVKPKLHVFGHTHYGHGREAVYYDECQRAYESLMARPAKGPLHDLVPGARWVDAFNVLRYGVASILWKWLMLGPGTNNGGLLANASLMYGNSGKLGNPVTVVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SQQ0</accession>
    <name>A0AAN6SQQ0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Mss4-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_36446</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854397">
        <property type="protein sequence ID" value="KAK4039574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SQQ0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF31">
        <property type="entry name" value="DUF636 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_2G12650)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="6">
        <location>
            <begin position="7"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="110"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="215"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="151"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="226"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="277"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4039574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="407" mass="44382" checksum="3C23F77223EEBA36" modified="2024-10-02" version="1">MDSAHNFVTISCHCGAARQTLSPRGSQDLFSGVLFCHCDTCRHSTGLLCTSYAPVSPPSVAGLQSYSTSPASTRYFCSTCGCHVFRAKHYSPSAPPEEWEWEVATGTITDAPESNLPQQWHHRHTNDTKDGGLSQWLPNTKPPLPAISPSDFDESRDDSPDDTLKASCHCTAITLLITRPSPDPALNPDSPYPDLLLPYTSTPTATVANPSHEKWYLRPVSPSPSPSTSSTQTNPQLSQKTKYLAGTCTCNPCRLTSGFEIQTWAFIPRRNISILIPPSSSSSSPSPNPDNSKLPGDYHPLDFTTLPRDNPLLPLKDYPSSPGRIREFCSTCGATVFWHDIFRPDLIDVSAGLFRAVEGARAGSWLEWWTGRVSFSEEASREREGGARGWGQGVVKALEGGMRGSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SRU6</accession>
    <name>A0AAN6SRU6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_36030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854387">
        <property type="protein sequence ID" value="KAK4039980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SRU6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="171"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="200"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4039980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="633" mass="68659" checksum="3828CC3E3189858C" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SRV6</accession>
    <name>A0AAN6SRV6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Nucleophile aminohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_35703</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854380">
        <property type="protein sequence ID" value="KAK4040282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SRV6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03754">
        <property type="entry name" value="proteasome_alpha_type_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000026">
        <property type="entry name" value="Proteasome subunit alpha type-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034642">
        <property type="entry name" value="Proteasome_subunit_alpha6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="7">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4040282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="254" mass="27908" checksum="8825A2F0FD824698" modified="2024-10-02" version="1">MAGNAGYDRHITIFSEQGRLFQVEYAFKAITAANIMSIGVRGKDCAVVLSQKKVPDKLIDPSSVSHIFQISPSVGCVMTGSIADARAFSQRAQSEAADFKYKFGYEMPCDALAKRLANISQVYTQRAYMRPYGVATTLVSLDSEFGPQLFKCDPAGYYIGYKGTAAGPKQQEALNHLEKKLKNKDHAPGDWKEVVELAITTLSTVLSMDFKKTEIEIGIVGGPRPDGKEGTHAGFRRLTEDEIDERLQAIAEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SRZ8</accession>
    <name>A0AAN6SRZ8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADP-dependent dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_45783</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854366">
        <property type="protein sequence ID" value="KAK4040954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SRZ8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05325">
        <property type="entry name" value="carb_red_sniffer_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052184">
        <property type="entry name" value="SDR_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458:SF1">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE SDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4040954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="242" mass="25221" checksum="80209BDD884BA61C" modified="2024-10-02" version="1">MPVYVVTGCRRGIGLEYIRHLSQTPGNTVFALVRSQTGDLTALQSVRESAAATVHILDCDISSAASIAGLPSRIAQAASPDIKIDVLINNAGILHSRAETALTMSPDDLLSHVQSNVIGPALMLQTLLPHLSPTARVANITSGIGSLALLAAGRIPVEATAYSVSKTALNMLTVHQQAQLKAQGSEVVVVTIDPGHVKTEMGGPHAVVEPEDSVKGVLGVLGRVGAEEGGRFWAYDGGEVPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SS26</accession>
    <name>A0AAN6SS26_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Autophagy protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_35913</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854385">
        <property type="protein sequence ID" value="KAK4040041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SS26"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4040041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="343" mass="38575" checksum="5D226183D8956A13" modified="2024-10-02" version="1">MGWFDGWFGSGKGGGSSDPLRRLDPKLREFLEKESPIKYNPPTPQQQQQQQQPQPQSQPSQLPPAQQNQPTTTTADTHPPSAPAESLYPDGRYAHLWKTYRPLAAIEAESKSDNEKLSDVLDAFKERKGLIGRAALENCAEEQVDWTACMKSGSWTARMTMCRDEVRKFERCYSAQSRLLKALGYLSVQGRGGEVDEEIQMRADELYHRMLAQEREVERAKEEGREAPVFKTLFEEEGGKKPATSSSAPAEVATAKGDGVHEPSAALVATWKDRLEKLPPEEREAEEKALRAEYRAKAEMASQIQGLWKEQAKEREARKAEGKETFMDRFSALAGSWSRPKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SS37</accession>
    <name>A0AAN6SS37_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">C8A01DRAFT_46556</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854385">
        <property type="protein sequence ID" value="KAK4040071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SS37"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010255">
        <property type="term" value="P:glucose mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000115">
        <property type="entry name" value="High-affinity glucose transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF40">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="132"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="317"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="345"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="379"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="415"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="452"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="24"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="517"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="537"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK4040071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="566" mass="61134" checksum="C95160E79B76E86C" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SSZ7</accession>
    <name>A0AAN6SSZ7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Threonine synthase</fullName>
            <ecNumber evidence="5">4.2.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">C8A01DRAFT_44920</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-phospho-L-homoserine + H2O = L-threonine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10840"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57590"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="EC" id="4.2.3.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:10841"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the threonine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.1" evidence="5"/>
    <dbReference type="EMBL" id="MU854347">
        <property type="protein sequence ID" value="KAK4042034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SSZ7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004795">
        <property type="term" value="F:threonine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01560">
        <property type="entry name" value="Thr-synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000046">
        <property type="entry name" value="THR4p Threonine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1380.10:FF:000003">
        <property type="entry name" value="THR4p Threonine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1380.10">
        <property type="entry name" value="Threonine synthase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029144">
        <property type="entry name" value="Thr_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037158">
        <property type="entry name" value="Thr_synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004450">
        <property type="entry name" value="Thr_synthase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051166">
        <property type="entry name" value="Threonine_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00260">
        <property type="entry name" value="thrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42690">
        <property type="entry name" value="THREONINE SYNTHASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42690:SF1">
        <property type="entry name" value="THREONINE SYNTHASE-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24857">
        <property type="entry name" value="THR4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14821">
        <property type="entry name" value="Thr_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 12" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="Threonine synthase N-terminal" evidence="15">
        <location>
            <begin position="20"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="14">
        <location>
            <begin position="103"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="12">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR604450-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF14821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK4042034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="549" mass="60855" checksum="1249ECEDF1F7A66C" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6STC2</accession>
    <name>A0AAN6STC2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Vegetative incompatibility protein HET-E-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_14454</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854350">
        <property type="protein sequence ID" value="KAK4041827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6STC2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="130"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="2">
        <location>
            <begin position="302"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4041827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="696" mass="77594" checksum="795B80F43CB639A2" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6STE6</accession>
    <name>A0AAN6STE6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Short-chain dehydrogenase/reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_34354</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854354">
        <property type="protein sequence ID" value="KAK4041630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6STE6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051911">
        <property type="entry name" value="SDR_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976:SF16">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4041630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="96" mass="10398" checksum="9AD15F2E4A66F353" modified="2024-10-02" version="1">MAPRVWHISGANTGFGLELTLKALKEGDQVIAAVRSPSKVPDSLKVDGVKVLQYDLCFSQEEMNGYAEKAFAAFGRVDVLVNNAGYAYMGAIEKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SU11</accession>
    <name>A0AAN6SU11_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_44007</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854332">
        <property type="protein sequence ID" value="KAK4043084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SU11"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4043084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="194" mass="21947" checksum="F1A93992B3080FD9" modified="2024-10-02" version="1">MRRPRFRRTSSRYSTPEHMMPIPQSPTQMSFRERDTGFPESFCGSRNTTRPHPEANLNPGACITEDDVNPARALIRHRMTFMAQQESHSRASTLDDRGDADEEGALSAFGRLAINSIRAAELRGLDAFLPSSRDGDSAESTDGMSSSDPDSPVHRGKEFDHHHHPKVDPRDAARDPRDGRRRRRGSFISRLMHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SUG5</accession>
    <name>A0AAN6SUG5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_33363</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854339">
        <property type="protein sequence ID" value="KAK4042561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SUG5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="164"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4042561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="179" mass="19194" checksum="FF7419B3FCA6D191" modified="2024-10-02" version="1">MVVPFLTGSRRGRFLSIVLLFTGLILWFGYQTPLSTVRPEPFDLHKGSPAVPNVARPPHDHATPQHDYPAQEAESSETEDIGSGSYGFESEPGSSGDRTTTTESTQTTDVAGTTTADFTGSYPAESTESTEIVVTETMATETTGSFLAESTESTETADIDDTTTTETTEPSRTPILTVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SUM0</accession>
    <name>A0AAN6SUM0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tse2 ADP-ribosyltransferase toxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_44221</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854336">
        <property type="protein sequence ID" value="KAK4042726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SUM0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041018">
        <property type="entry name" value="ADPRTs_Tse2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18648">
        <property type="entry name" value="ADPRTs_Tse2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tse2 ADP-ribosyltransferase toxin" evidence="1">
        <location>
            <begin position="46"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4042726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="208" mass="24118" checksum="2FF2AC94A45DD721" modified="2024-10-02" version="1">MLTPVSRSLLGQRLPRMAPRARVPRLRCAISQMPFQARAIFATFPATMHYYSPHRLSSLFDCREKDSRPDDLRDEAVYVADDGLVYPRTVSNGAVFMPNTFWMQELARMYFDQYYLDLVDEGKQVEEPYIYTVAKGTPVPSRLILVHEHKELFSLQPSEQGMSLNDLNRSLDEFYDKYALKKAADEWLGEHPLRECIDGADEQTWMAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SV38</accession>
    <name>A0AAN6SV38_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Calcium-activated chloride channel-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_43685</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854328">
        <property type="protein sequence ID" value="KAK4043370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SV38"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007632">
        <property type="entry name" value="Anoctamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049456">
        <property type="entry name" value="Anoctamin_N_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049452">
        <property type="entry name" value="Anoctamin_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308:SF73">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04547">
        <property type="entry name" value="Anoctamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20877">
        <property type="entry name" value="Anoctamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="308"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="344"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="386"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="453"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="580"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="622"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin alpha-beta plait" evidence="8">
        <location>
            <begin position="18"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin transmembrane" evidence="7">
        <location>
            <begin position="193"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="680"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="96"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4043370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="724" mass="81401" checksum="AB280057CD2EF2AA" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SVD4</accession>
    <name>A0AAN6SVD4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">25S rRNA (uridine-N(3))-methyltransferase BMT5-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_32452</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854327">
        <property type="protein sequence ID" value="KAK4043521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SVD4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070042">
        <property type="term" value="F:rRNA (uridine-N3-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019446">
        <property type="entry name" value="BMT5-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF26">
        <property type="entry name" value="FERREDOXIN-FOLD ANTICODON-BINDING DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10354">
        <property type="entry name" value="BMT5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="25S rRNA (uridine-N(3))-methyltransferase BMT5-like" evidence="2">
        <location>
            <begin position="86"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4043521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="387" mass="41866" checksum="8BCBFF45515ED881" modified="2024-10-02" version="1">MAKGRGRLQHAVKAVKQQQKTPKPTGPPAPASKTTPASKPGTRPGPGPGLPAAKKQKTGTANKPNNGPQQQNQKPTIPFSPADPILLIGEGDLSFAASLITHHHCTNVTATVLEKDFADLSTKYPHVQTNTAVIESPAHPGCRLLYGIDARKLPPFTTTTPPKSKHDPTKTPPTGAMKRIIFNFPHTGGKSTDVNRQVRHNQELLVDFFRRAQPSLCPGGTIVVTLFEGEPYTLWNIRDLARHAGLQVERSFRFVAGVYPGYEHARTLGVVRNRRGEVATKAWRGAERGARSFVFVRRGEAAADVKKRKRGGGSSDEEEEEDEVSEGEGWGDDGEGDGFEEEDRDGSEEDRDGSKEDDHDQNEVGPRDGADNSEGRHGDGDGASEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SVE2</accession>
    <name>A0AAN6SVE2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_12533</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854322">
        <property type="protein sequence ID" value="KAK4044017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SVE2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4044017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="457" mass="51825" checksum="39D50F16BB700E27" modified="2024-10-02" version="1" fragment="single">SHQTMNILACNDDVLYLILRCLSQADLLAVCLVHRRLHGLAEPILYSAIDINWQGSLTKPHPITALVRSILGRTRRATYIRSVSCSGRNKWQLAYRGKALRFSVLEPDLKEPISFVKRSQVPFRDSWVEELRNGSIDAYLAVLLSQLPRLRHLHLGPYYFTESRLVGLVFQSVLSGSPPGPLGPCLQRLETVSLQREESRHTEWHIRNTANVLPLFYLPSIREITAPIDDPVVFSWPTASPPSPNLVSLGIADLRESHLGQLLSITRHLHSLQWTWHFSPDFEDEYNSPVVDLGLIMPALEYARDTLTELTIHGVCDYAYRAALPVPLRVQGSARGLSRFNQLKKLMIPPVFITGFSIPIQNSLETCLPPNLESLTLTDDLFRDIDINEQWDELGHTRALVPWLANVETSTPRLRKLCLVLENPENCIGYEAVDVRNEIRELASRAGIELEIKELYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SVH0</accession>
    <name>A0AAN6SVH0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Oxidoreductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_43041</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854321">
        <property type="protein sequence ID" value="KAK4044107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SVH0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF37">
        <property type="entry name" value="CLAVALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4044107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="296" mass="31588" checksum="879DBC00BC02AD1E" modified="2024-10-02" version="1">MTGKPSPLGLDFTSKTHHDTYAAINPATDPAPCAGKTVLVTGAAKGIGRAIVVSYAKAGASRIAITARGDASVTHAEALRAAAEAGRTGVELLVLKLDVTDHASIEACAAELRSQWGHIDIVVNNAGYLAPFVPLGDGDKGDWWKTWEVNVRGVYWVAHAFLPLVLGSADKTIVNVTSVGALALTPGASAYQTSKLAVLRLSEYLIVDYGSRELIVYSVHPASVVTDLASQMPAALVEAVCNDTPELAGDSVVYLTSKRREWLAGRYVSCAWDMPELMGREQEIVERNLLKLQMNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SVW9</accession>
    <name>A0AAN6SVW9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">H/ACA ribonucleoprotein complex non-core subunit NAF1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Nuclear assembly factor 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">C8A01DRAFT_31689</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854321">
        <property type="protein sequence ID" value="KAK4044091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SVW9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005732">
        <property type="term" value="C:sno(s)RNA-containing ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000493">
        <property type="term" value="P:box H/ACA snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.230:FF:000002">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Gar1/Naf1_Cbf5-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007504">
        <property type="entry name" value="H/ACA_rnp_Gar1/Naf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040309">
        <property type="entry name" value="Naf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31633">
        <property type="entry name" value="H/ACA RIBONUCLEOPROTEIN COMPLEX NON-CORE SUBUNIT NAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31633:SF1">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX NON-CORE SUBUNIT NAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04410">
        <property type="entry name" value="Gar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="40"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="369"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="52"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="165"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="370"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="389"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="449"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="529"/>
            <end position="578"/>
        </location>
    </feature>
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            <end position="614"/>
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            <end position="631"/>
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        <location>
            <begin position="639"/>
            <end position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00076743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK4044091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="691" mass="73165" checksum="F2FEFAAD6DFF3F7A" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SW84</accession>
    <name>A0AAN6SW84_9PEZI</name>
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        <recommendedName>
            <fullName evidence="5">Pre-mRNA splicing factor CLF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_42734</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854318">
        <property type="protein sequence ID" value="KAK4044555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SW84"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
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        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
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        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="410"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="793"/>
        </location>
    </feature>
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            <begin position="266"/>
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        </location>
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        <location>
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        </location>
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    <feature type="compositionally biased region" description="Pro residues" evidence="1">
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            <end position="779"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4044555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="793" mass="83431" checksum="C6CD8746A1B5EBFC" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SWG7</accession>
    <name>A0AAN6SWG7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ketoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_11900</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854317">
        <property type="protein sequence ID" value="KAK4044646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SWG7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42901">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42901:SF1">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="5">
        <location>
            <begin position="32"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4044646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="299" mass="32067" checksum="2484AA605ABC8D77" modified="2024-10-02" version="1">MAAPFPSPTATWHDNTYESLSPTRPEVSAKGKSVLITGGGTGIGAETARSFAAAGASRIALLGRREQPLLETKAAIEREFPGVEVLTAPTDVTKKSEVDAAFARFLDGRGRLDIVVSNAAKTGPHESVADADPERFMDAVDVNVRGALFVAQAFLRYAADDAVAVNVSSSAAHLNFGPGFVAYSAAKLAAVRLWDSVGFANPGLRVFHLQPGVVDTDMNKESGGVKAVGFEDHVSLPATFIVWLASLEARFLKGKFLWSNWDIDELKARRSELESSTLLNVTLSGWPFGENTWKAKWSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P406</accession>
    <name>A0AAN6P406_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_42235</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854891">
        <property type="protein sequence ID" value="KAK4031299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P406"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="465"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4031299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="522" mass="58084" checksum="69D552E60363B4A0" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P5B6</accession>
    <name>A0AAN6P5B6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_20900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854671">
        <property type="protein sequence ID" value="KAK4031959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P5B6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4031959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="104" mass="11591" checksum="AED3F9CE0BC8A055" modified="2024-10-02" version="1" fragment="single">SSSPLTHAAPQESRTMCQWERKVCQCGHAGQLKRMEYSCDIYRRHVFGTCPFDDATSRIHDVLKFSLCPACHARDNDKQRKKSRKNVLEGGSGCSGSSGGSTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P5K8</accession>
    <name>A0AAN6P5K8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sarcosine oxidase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_50964</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MSOX/MTOX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854636">
        <property type="protein sequence ID" value="KAK4032194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P5K8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051698">
        <property type="term" value="F:saccharopine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008115">
        <property type="term" value="F:sarcosine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045170">
        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961:SF37">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="6">
        <location>
            <begin position="14"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4032194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="433" mass="47790" checksum="4CE32111E0678DDA" modified="2024-10-02" version="1">MEPSTAGKRHPATVVIIGAGVFGLSTALHLRKSHPDVDVTVVDRMRGNRGGASSDHNKIIRADYPDPVYMGLAIEAQECWRKDPMLQPYYHECGMLFAEDINIGRASYANYKKIGQEPLSGRADTDAEYNYYNPHSGWGEAEEAMASVFQAALDAGVTFTEATARKLLPAPDGSCQGVTVQKDGELQDLVADLTVVCTGAYTAKLQADTAPERDELQVAGRMVAAAAVQCTATYPPDQEEKLLQAPVHFIGMWHTHGESIPPFKGRLKFNCEVSFLNMTYHEGLGKEISIPPAEQSQSTFSQDVLDGLKQEVANVVRNKYGNYVPGIQIENYRMCWDAVSPNQDFVIDYHPHCNNLIIAGAGSFHSWKFLPTIGKYVVQRIMGTLDEPLARKWAWDRENVGAACEMYIPTRDVKNIGPFQGWPRPGELVPVAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P688</accession>
    <name>A0AAN6P688_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_41121</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854610">
        <property type="protein sequence ID" value="KAK4032439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P688"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4032439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="274" mass="30645" checksum="F4B01CAE71D989B1" modified="2024-10-02" version="1">MDNADSQPVSGAPEPYPYVLDLGKPGDADCGRGVDETLGVIAALEGLGIPCCVVGTKALVYYGAHRVPLTWEICVPTDSFDRATALLTSPPLNEKYEVWHPVPPVPGSLMHTYPHFTLKGVNFFFILLPAFECLLSPSPDQREHSASGIPYPKLELFAQSLLDLQQYADLADLIEGMDLDEAWGETHLQLDKPAPVEYIRKKNDMIARSLPESMAAGAFLALLSEGPRPPRDVWRHIVSKKHRRVNDELPKYRYLTRFRKVGSRDPRENKEREV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P6S0</accession>
    <name>A0AAN6P6S0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_21337</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854811">
        <property type="protein sequence ID" value="KAK4031433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P6S0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4031433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="79" mass="9470" checksum="45250BA5A04D70DE" modified="2024-10-02" version="1">MPNTDRSARRKRDRSGENFRKRWQTLVKTGHALHRNYSARIYFSIFIPRTRRDFVFRSDKDVLPIVPGELVCSFLLMIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P6Y2</accession>
    <name>A0AAN6P6Y2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BAH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_20209</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854577">
        <property type="protein sequence ID" value="KAK4032770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P6Y2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04370">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46364">
        <property type="entry name" value="OS08G0421900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4032770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="198" mass="23201" checksum="98E9376DEA2D20C5" modified="2024-10-02" version="1">MASAGKTPRAECPFTIKIVDPRDKEQKKKKRRRTENGEEEDTAQCINQQMSPFAPCGKFKTHETMDLYYQVDPAKTWTDMTRYNSFVLNGIKYFSEGFIYVANDSSIERQKAVNHNEPMHPRMKSDDGWVARILEIRASDEHHVYARVYWMYWPDELPQGTYDGRKTIQGRQHYHGMNELIASNHSKQPVAHARPEQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P7B2</accession>
    <name>A0AAN6P7B2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glutamyl-tRNA amidotransferase complex subunit Gta3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_40467</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854553">
        <property type="protein sequence ID" value="KAK4033078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P7B2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030956">
        <property type="term" value="C:glutamyl-tRNA(Gln) amidotransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070681">
        <property type="term" value="P:glutaminyl-tRNAGln biosynthesis via transamidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003837">
        <property type="entry name" value="GatC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049545">
        <property type="entry name" value="Gta3_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15004">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT C, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15004:SF0">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT C, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20978">
        <property type="entry name" value="Gta3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamyl-tRNA amidotransferase complex subunit Gta3" evidence="2">
        <location>
            <begin position="80"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4033078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="221" mass="24245" checksum="68E87280AC48B181" modified="2024-10-02" version="1">MTSPRRPLSRLTRRLLSTGNQSSTAPPRPQHDPYALLSRPTWSIRALLPPSPSNNPPSHPVAPLSEPTTEIDQPPSENDPQITPQQLTHLLRLSALPQPPTQTTSHRLLTTLHAQLHFVRDMQRVNTAGVAPLHSIRDETPQGLLEATVTTSTLAEALQQEEVVGRCRRPRRRRTGKGGGQIQMQIEGVEDWDVLAGAGEKVGRYFVVRSGKGEAAKEGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P7F0</accession>
    <name>A0AAN6P7F0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_50215</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854549">
        <property type="protein sequence ID" value="KAK4033138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P7F0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF10">
        <property type="entry name" value="TOL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="23"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="416"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4033138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1091" mass="121794" checksum="451208F82A50B705" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P7N7</accession>
    <name>A0AAN6P7N7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_50118</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854541">
        <property type="protein sequence ID" value="KAK4033274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P7N7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206:SF1">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4033274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="430" mass="48298" checksum="06F5F6EE590C7036" modified="2024-10-02" version="1">MIELLLRPAVLVPAVALVAFVIHQLFFAGPKLPKIPILGAKEGDWFPFYQAMWRNTVDFKAAVQVADQKYREQAVLMPLMVAPNMVLLPRSETQFVTDQPDSVLDMHTQAMDSLQIDYTTTDPSLVHNPVHHKLITTTLTNQIGNLVPDVAEETAWGFDKYWGVPDEYQEVCVYDTMRKIVGCVTNRVFVGKPKCRDPALLTEARSRGKVSWPRTQRLPAVDNQASQGHRAILELAASKQQYIDELRAEIEGVLAEHGGEWNKRALAKMQKLDSVMRESARLNSFVTIGLSRAVVAKDGIVTPSGVRIPRGLTVNVPSYPVFQDSDIYPDAQEFKPFRFAEQRSDESVEYVKRAAKAFATTSTDYLAFGHGRNACPGRFFASNELKLMLAHLVLSYDMEIGGDRPRNSWFGLNRVPPLQATIRIKKRVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P8J5</accession>
    <name>A0AAN6P8J5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_42100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854807">
        <property type="protein sequence ID" value="KAK4031442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P8J5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4031442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="289" mass="31531" checksum="415EBDD3254FBBE0" modified="2024-10-02" version="1">MPDAKKGHRASIHDVSDGTPLRVPPTAAFLGYRPFPAVMNLYANYTGVLSSIKSHKLCGTAESDFLYLVEYHLGYTPRGPLNFGRGYYLRNGTTFKDPILTATGEDFPIPLLVSLFDPMTIVKLPPLDMAKNPRDMVDEVLRAEKSKEHGVAFCFAVEVGVKSMQRESFEWRKATAAPGERQGENGHKIKTRYTLHRLAPSCPATSTSTSSTSNRAASDAETVAVLGFNHVLSFTHLFTLELKGAGLTGELGDRWTLMVVTTALSIHLLRQLGKTGKATVGAAQKIHGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P8N5</accession>
    <name>A0AAN6P8N5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_42050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854783">
        <property type="protein sequence ID" value="KAK4031502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P8N5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4031502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="192" mass="20763" checksum="C17CBD458A84EFD9" modified="2024-10-02" version="1">MASDGNIPGAGDNLRDIKGDIIAKLDETAHPSLRNFFEGLRVEVVGGAATLNLIESIQKDIAGREFLKIVDNEALTRVYAERDTWEKAAGKIKSGGGGGDIAVDCDGLMLYPTPFTGDEKDTAKRKKIIYASALLEGSAAAGVFKGVQKVTTNPDNSDTWPWKTVAAFIDHLAHSFFKDLLYRKGKADDYKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P993</accession>
    <name>A0AAN6P993_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_39464</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0357 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854496">
        <property type="protein sequence ID" value="KAK4034089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P993"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018559">
        <property type="entry name" value="DUF2015"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28023">
        <property type="entry name" value="UPF0357 PROTEIN YCL012C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28023:SF1">
        <property type="entry name" value="UPF0357 PROTEIN YCL012C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09435">
        <property type="entry name" value="DUF2015"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4034089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="134" mass="15138" checksum="132B5AF128C6917F" modified="2024-10-02" version="1">MGYLLYSLTFLALLTGTALYLTRARWLPSFQDRVHSIRFPGSDYLYSRLAPGGSFEDDMEAGLSSANFDLTGNVEGGDGRAGLDDAAKREVLRIMKKRRLKFDEARRVYMEQRFKENGIGADGRPRDPKFVSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P9D0</accession>
    <name>A0AAN6P9D0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_39342</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854491">
        <property type="protein sequence ID" value="KAK4034171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P9D0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="31"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4034171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="127" mass="14005" checksum="FF415DD21D54DC88" modified="2024-10-02" version="1">MQDSLGIAGFVVTALGFLFAVESCWWQRRQLANTERKLSEAEAARNTAEAEAGKLRVEMEEEKVVGKLRGEVEKEKKEVGELQDKAADTERQRVAAVAEGDRLREEVKRLAEVLKSIAIAATAGHPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PAJ8</accession>
    <name>A0AAN6PAJ8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_39703</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854508">
        <property type="protein sequence ID" value="KAK4033817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PAJ8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4033817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="486" mass="55858" checksum="EE386706002D7BD4" modified="2024-10-02" version="1">MSWDPDNSVMPGEERDQEEQAKAWYDEPTRARNRHLEAENLRLKKLLRENGISWDPRLTLDPDDPTKGTWSSPKRSRTRKSKGPTSLSQENRHLPVLPVEIQLYILEYALTSNDPIIDPLVKLNREAVTVAERTRDNQLAIGFLATCKAYLAEGTRFLWANNEFIFTSHLALRNFANLSLEHRKGIKHVTFRIIARYYDDEERKRLAPYPSAVDTYYRTINLRATPRIKEDNLARKGFRSYAWEQVVDFLDAMRPPFDPNHPKGQPRPRLLPGLDSLRMDFVNFPDSFLTPGGGPFLHSYASHDLGCTLNELQLTGLPACDFGQELVSELSGMIKDDGLLLKSDSTFVFSGSQLRPMSSRPKWMPSWEPKVIRSWKALAAEYARSKGRSPSQPAHGHHRHAHAGHHNMPPAPKEEGHPESLWKERRTMFKRVPIEQDDDERVWAEFDRLTGREIEPEEYDSEDDEYDISDLVCPSCDVMHAPSGEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PAW4</accession>
    <name>A0AAN6PAW4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase metallopeptidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_38541</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854459">
        <property type="protein sequence ID" value="KAK4034969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PAW4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098636">
        <property type="term" value="C:protein complex involved in cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046871">
        <property type="term" value="F:N-acetylgalactosamine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070492">
        <property type="term" value="F:oligosaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030247">
        <property type="term" value="F:polysaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04327">
        <property type="entry name" value="ZnMc_MMP_like_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2080">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052487">
        <property type="entry name" value="Galactose-binding_lectin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037221">
        <property type="entry name" value="H-type_lectin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019019">
        <property type="entry name" value="H-type_lectin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46938">
        <property type="entry name" value="DISCOIDIN-1 SUBUNIT A-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09458">
        <property type="entry name" value="H_lectin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141086">
        <property type="entry name" value="Agglutinin HPA-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase metallopeptidase" evidence="1">
        <location>
            <begin position="46"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4034969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="525" mass="59007" checksum="137816DEF52C7D95" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PB32</accession>
    <name>A0AAN6PB32_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_48641</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854454">
        <property type="protein sequence ID" value="KAK4035139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PB32"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="4">
        <location>
            <begin position="231"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="26"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4035139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="424" mass="46394" checksum="4364615950890BD8" modified="2024-10-02" version="1">MGLLSRTLWPLRQSAIKTKFHMSTAAGVATSPAQATSHPRTSPPSPSPNTLNPLSKTMPPGFKASVAHLPTFPLPPTITSSASDHALGNALVDAWRRDGIIQIAMDSTQRQLWADAKAASRAFFGRPHAEKAACVDSQSYAGYIASGEEITDGIVDYSEIFTITKDLGVEDPRVRAGWPGHGPCPWPDAGMKGVMKRFEGRMGEEGEKLLTLAELGLGVPEGALTGYTRDGWHHTRVLRFPPRNATNGKGKKGRGIGSHTDYGLLVIAAQDEVGGLFIRRPNQDEKFANWEKSAAGLNEDDDSWVYVPPVDGVHTVILGDMMQYLTRNYLTATPHKVGLNKRERFAIAYFHEPSFQAVLKPLEGGCGGMAQQSADIEGVHYGTHITNMFMRNYPDRITTRRLVAENRYSLLKRPELRTMCATTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PB46</accession>
    <name>A0AAN6PB46_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CRAL-TRIO domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_39969</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854522">
        <property type="protein sequence ID" value="KAK4033563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PB46"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.20">
        <property type="entry name" value="N-terminal domain of phosphatidylinositol transfer protein sec14p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051026">
        <property type="entry name" value="PI/PC_transfer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN YKL091C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657:SF3">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G09260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="97"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4033563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="429" mass="47957" checksum="8C4F89712A7F92B8" modified="2024-10-02" version="1">MAETTSVGSHDVGYPHGHLGHLTEEEDKQLRLFKDFLEEKGLYKPGPPPSHDDQTLLRFLRARKWSVNDAYGQFKDTEEWRQANQLDVLYDTIDVDAYEETRRLYPQWTGRRDRRGIPLYLFQIRHLDSKTVSTYEKASESATVSKAQTDGSTPQRLLRLFALYENLTRFAQPLCTELTDRDHAGTPITLSTNIVDVSQVSLRMFWNLKAHMQSASTLATAHYPETLDRIFIIGAPYFFSTVWGWIKRWFDPITVSKIFILSAAEVKPTLEAFIEPRNIPKQYGGELEFEFFDRPNVDPRIKEAVTWEEGYTDFPEGPAYWLPVDGGKRLACMAVGSKGGEARRERVCTVPVTFFKKGEEAAAAAAEPAGEAAAASNETAAPVDATADAAVERVQKLSIADNSVANEIEEKVAADAGGQPEQKAAAVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PB54</accession>
    <name>A0AAN6PB54_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_40801</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854578">
        <property type="protein sequence ID" value="KAK4032762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PB54"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.30:FF:000027">
        <property type="entry name" value="Protein FMP25, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053245">
        <property type="entry name" value="MitoProcess-Associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47563">
        <property type="entry name" value="PROTEIN FMP25, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47563:SF1">
        <property type="entry name" value="PROTEIN FMP25, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="281"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="345"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="421"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4032762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="584" mass="62408" checksum="5679929EC6933A3F" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PBT9</accession>
    <name>A0AAN6PBT9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aspartic peptidase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_17809</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854441">
        <property type="protein sequence ID" value="KAK4038064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PBT9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF30">
        <property type="entry name" value="MID2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042934150" evidence="7">
        <location>
            <begin position="16"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="493"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="432"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="464"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="571"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="465"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="576"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4038064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="618" mass="65724" checksum="E0EFB462E4E3E160" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PCQ6</accession>
    <name>A0AAN6PCQ6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Anaphase-promoting complex, subunit CDC26</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_48686</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854456">
        <property type="protein sequence ID" value="KAK4035075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PCQ6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018860">
        <property type="entry name" value="APC_suCDC26"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10471">
        <property type="entry name" value="ANAPC_CDC26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="35"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="50"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="182"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="291"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4035075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="323" mass="34997" checksum="FAD78802D2A20715" modified="2024-10-02" version="1">MLRRAPTILTLTPEDLADYEDRSADRARAAELVARQQAADARSRARHDATSAAAGLRRAALATVTPTAGSSTSRYNNNNNGGSLDFHGARVLSSPAEHQFSDEEESDDEAETSYYARAQSQAARVVSFGRGQVFGHHVDEDEEEAEEEEGEQELEDDNDGASMGDHPLHHHQDSFLPSSQRTTTTAPAETPTNPRDTRLNNGPPPIQQQRRTTRERTADRETATPPTRETRRGNTQTQTQAADLPPPPPPHKTPHTHVIPAPAAASGTCTRDAPARIRTTTSDYCSRRHARGEGAAEPGRADRGCGAEEGEVASNMISNSTKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PD35</accession>
    <name>A0AAN6PD35_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phenylacetyl-CoA ligase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_37306</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854420">
        <property type="protein sequence ID" value="KAK4038739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PD35"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05911">
        <property type="entry name" value="Firefly_Luc_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000007">
        <property type="entry name" value="4-coumarate--CoA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF149">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="4">
        <location>
            <begin position="32"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="5">
        <location>
            <begin position="458"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="157"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4038739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="559" mass="61417" checksum="70DD531891B9DFC3" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PDG0</accession>
    <name>A0AAN6PDG0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_38169</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat ESC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854446">
        <property type="protein sequence ID" value="KAK4035377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PDG0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051243">
        <property type="entry name" value="PcG_WD-repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053893">
        <property type="entry name" value="PRC2_EED-like_ins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10253">
        <property type="entry name" value="POLYCOMB PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22038">
        <property type="entry name" value="PRC2_EED_ins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
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        <location>
            <begin position="134"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="183"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Polycomb protein EED-like insertion" evidence="7">
        <location>
            <begin position="381"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4035377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="524" mass="57393" checksum="1345D5EA8AAD2A1D" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2025-10-08" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PE24</accession>
    <name>A0AAN6PE24_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tetratricopeptide repeat protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_36836</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854407">
        <property type="protein sequence ID" value="KAK4039213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031101">
        <property type="entry name" value="Ctr9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14027">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN CTR9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14027:SF2">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN CTR9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13176">
        <property type="entry name" value="TPR_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="606"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="801"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="983"/>
            <end position="1281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="983"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1054"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1101"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1111"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1125"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1144"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1179"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1202"/>
            <end position="1221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4039213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1281" mass="143362" checksum="5AC2848BACFD3EFF" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PE82</accession>
    <name>A0AAN6PE82_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DSBA-like thioredoxin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_48070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854433">
        <property type="protein sequence ID" value="KAK4038310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PE82"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03024">
        <property type="entry name" value="DsbA_FrnE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001853">
        <property type="entry name" value="DSBA-like_thioredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13887">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13887:SF41">
        <property type="entry name" value="THIOREDOXIN SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01323">
        <property type="entry name" value="DSBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DSBA-like thioredoxin" evidence="1">
        <location>
            <begin position="6"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4038310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="231" mass="25273" checksum="EE14B85AD5151ED5" modified="2024-10-02" version="1">MANFNIKIVSDAICPWCYVGKKRLERAIEAYKRDVPGGASDSFTVTWHPFYLDPSLPKVGVDRDVHLTKKFGPERLAMATAHLKALGAAEGINFSLKGKIGNTRDAHRLVQLAKTKSNEAENRLVSTLFKSHFEDDADITSQDALVEIAEKAGLDKTEVTDWLSQGEGGQEVDREVEEAYSKGIHGVPNFTINGRYQVEGAQDVQKFLEVFARAKKSSPDVSTGSSAGVSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PEX4</accession>
    <name>A0AAN6PEX4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thioredoxin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_48589</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutaredoxin family. Monothiol subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854453">
        <property type="protein sequence ID" value="KAK4035151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PEX4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005796">
        <property type="term" value="C:Golgi lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004362">
        <property type="term" value="F:glutathione-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03419">
        <property type="entry name" value="GRX_GRXh_1_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000093">
        <property type="entry name" value="Glutaredoxin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011899">
        <property type="entry name" value="Glutaredoxin_euk/vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014025">
        <property type="entry name" value="Glutaredoxin_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02180">
        <property type="entry name" value="GRX_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694">
        <property type="entry name" value="GLUTAREDOXIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694:SF5">
        <property type="entry name" value="GLUTAREDOXIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00160">
        <property type="entry name" value="GLUTAREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="3">
        <location>
            <begin position="166"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="96"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="96"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4035151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="272" mass="29329" checksum="A7CE66F1F86D7C09" modified="2024-10-02" version="1">MPSQRRVRVITYLVLAGIVTLLFLSQARHSRGSDQSLQDFRSKTVNAMEKNHEAGRSVAGTGGQAGQKAIADHDVDADGDIDEDDTLLAKQMADRLRQAEQKAKDNAKAKGPNKPESPQEVVGVGSSASGQKRPAPKDKAETQPAETEEDHEVEGVLNSILKKSPVIIFSKSYCPFSKMAKGILLDKYTIEPAPFVVELDQHPLGPKIQARLGEMTGRRTVPNVMVYGQSIGGGDDISALDKEKTLADKITSLGQTRISIALRFAQSAQKAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PF08</accession>
    <name>A0AAN6PF08_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_36224</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854392">
        <property type="protein sequence ID" value="KAK4039774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PF08"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="83"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4039774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="232" mass="24114" checksum="D0EB6C1E6DF3C9E1" modified="2024-10-02" version="1">MSFSVPPLVQGNLLVAAFTVLLVWAALVVTRQRRANVAATNSTETPPKPTTPLSEQQALSTSTTTTVTKPIQIPAPKLNNNSNTDNRNPLPTLTPPTFNTPLSNNNQNQNTNTHANYYTTFNHPPSLPSTSVTSSGGAIFPWRASFSSLTLARRRSSNISIGSTTPLCAGAAAVVPGDSVLGRKGSACVRWSSSEGEDGSGSSERCGSGSNSGGRVGSYSSEGVLFGVGGQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PF64</accession>
    <name>A0AAN6PF64_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein BIG1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">C8A01DRAFT_16234</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BIG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854391">
        <property type="protein sequence ID" value="KAK4039813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PF64"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006078">
        <property type="term" value="P:(1-&gt;6)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037654">
        <property type="entry name" value="Big1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046756">
        <property type="entry name" value="VAS1/VOA1_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28285">
        <property type="entry name" value="PROTEIN BIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28285:SF1">
        <property type="entry name" value="PROTEIN BIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20520">
        <property type="entry name" value="Ac45-VOA1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043049795" description="Protein BIG1" evidence="11">
        <location>
            <begin position="20"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="235"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="V-type proton ATPase subunit S1/VOA1 transmembrane" evidence="12">
        <location>
            <begin position="234"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF20520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK4039813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="284" mass="30865" checksum="5D46C5ED79AA6595" modified="2024-10-02" version="1">MKLSTTVALLACAASQAQAFSDSSPFILFSTANLRTPPSTPQLQTAAQVLTTAKSLLASCPTRRYLLVSQPNMHAADVRADSSSSDSSCRMPNLCRAAGGQNSWAVAEVVGQVSGKSLEEYIARACRGKKKEGVSVERVELRHLPAVSDREDGGEARRGEVLGDNDHELGKLLDTLDGDYTIVVFSDPNEFKAYEPDFGAPVRMDLRRWEEAPEVVAQRKANETDNRPLFEKYQFFTPGIFMAFIVLAVILSILGVGLKALASLEVSYGAFDKEMGPAAQKKQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PFT2</accession>
    <name>A0AAN6PFT2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_15943</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854383">
        <property type="protein sequence ID" value="KAK4040143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PFT2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF1">
        <property type="entry name" value="RAS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="316"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="333"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="348"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4040143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="526" mass="55816" checksum="96A7AD19D8CC40D2" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PG78</accession>
    <name>A0AAN6PG78_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_46279</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854378">
        <property type="protein sequence ID" value="KAK4040383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PG78"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47251">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G04180)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47251:SF1">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G04180)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="23"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="124"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="134"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="159"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4040383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="178" mass="18516" checksum="F60858D427B6A855" modified="2024-10-02" version="1">MPPRHQTLPPAQTSSAREALQSFYCQLCQKGYSRMNDYEAHLSSYDHSHKQRLKDMKAMVRDPAAAARARRQEEKAAGGVISIKLGEAAAAGGGVGGSGAGSGGGGGFKKGGFKKSGFKSAFGPVGGGGGVAAPKEDAGLRKQEGEGKTGLPAVKSELVESDTEDEGYEVYDPRRPTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PGI9</accession>
    <name>A0AAN6PGI9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_15850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854381">
        <property type="protein sequence ID" value="KAK4040227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PGI9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042831">
        <property type="entry name" value="Ribosomal_mL40_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39150">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L28, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39150:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4040227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="211" mass="23522" checksum="0E84B331422D7082" modified="2024-10-02" version="1">MSFSLPSLRGLASRFLTRPTALTPTPFTPSTTTQCLAPSTRALSTTPSTLAPPGAKNPNKGSKAGGKPGGKPQAGGKKKGGKRGVEEQRDPKMINMLSHFAVLSPNRIPPPLRMGRNRHLRHWTIHRAWLLFRRREREARERNLMRQHQSMSNACEALRLTSGPGTRDEGYLFRVAMEKKGVYGLHGVPIEYARAQTETPAKVAWNHDWKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PGK5</accession>
    <name>A0AAN6PGK5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_35522</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854376">
        <property type="protein sequence ID" value="KAK4040481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PGK5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4040481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="221" mass="24632" checksum="EFA468F9AD36D06C" modified="2024-10-02" version="1">MTNLQRRSIFPRRRGGTRHRSATARRASQRANSARRRTRPTSQTNSSEWQDIDSDSGSSWSDSVAIATPTDSVSSSTPPTNDRRTRNHNSHRSRRISLSILRADPRWREEGVEVLEEGSEGEEEGEGKEGEKGTESKPEKKPEKKPESERKSELEKTPEWEPEPGQEPEQEPGKGGGEGEGKGEDDNQQTASGVSPRLRILIKGWPESPGLCLPSRNGPYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PH92</accession>
    <name>A0AAN6PH92_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_17424</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854427">
        <property type="protein sequence ID" value="KAK4038500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PH92"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4038500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="296" mass="31260" checksum="F0721779AC70B593" modified="2024-10-02" version="1" fragment="single">LHELLTHFRPFAATDPRDKVYALLGIASAVEHIPQSLLPAISYHPSTTVLDVLWEVVATHLRVHQNLDFLDDAYGMEGDGVEEGWPSWMPLWYQHDDDDGTLRSLGGCRCRWEGWGSGLAWGGIEPVGGARAVVAGMDKGGGGTLIVAGKVLGLVGMVPGEVFDQDVERMERLAVRRRWAGLFGLEGVEALRQVLTGLRCAGRIGEGEAKRRMEEALGGVGAGGEGAGQAVCGHSDGVWVGRGHRAVGSPAAGGEDRGAGADVGEQEVAQSRWAAVTVGCGGADDHRLQRTAALCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PHF1</accession>
    <name>A0AAN6PHF1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_34989</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854366">
        <property type="protein sequence ID" value="KAK4040931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PHF1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4040931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="355" mass="40355" checksum="E7CFA3A0C9851182" modified="2024-10-02" version="1">MNDDACLEKVLAYPDMLSRLSAARKLRTERTKFDDVPLPGLSDWLPSLVIPGDGDAGGLLLKTFNDGYALGEVVVAMSFHLSTQVHKEVLEFVLDQVSTQSFDVSKIWIPGFITASVDWMKKRPRHVNRAHLEAVCDRFVEQDGFCNTHFNGVMDEHGRIGKMDLNPVDLVRFMSVLDDACPGSLARQIQQMGLSLSTVTTEMLQWFWIEWIEWGLGEELETEPGIAEFSTAILYTYACKSLGPPPPQHPDDLAWPVAIEEHMTDFWEFLADPVRPEGSFCWDPSQREAMKLVECLPRLEMSVDSETKPYTTVIRKRSRADPEHHTAWAKRKEDVREDALARFGEMYLRNMTGAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PHN1</accession>
    <name>A0AAN6PHN1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA polymerase II transcription factor SIII subunit A-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_17217</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854420">
        <property type="protein sequence ID" value="KAK4038725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PHN1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070449">
        <property type="term" value="C:elongin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Elongin-A_domain"/>
    </dbReference>
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        <property type="entry name" value="RNA_pol_II_trans_fac_SIII_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15141">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF06881">
        <property type="entry name" value="Elongin_A"/>
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            <begin position="208"/>
            <end position="506"/>
        </location>
    </feature>
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            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
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            <begin position="260"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <begin position="314"/>
            <end position="326"/>
        </location>
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            <begin position="362"/>
            <end position="373"/>
        </location>
    </feature>
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            <begin position="410"/>
            <end position="422"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK4038725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="506" mass="55347" checksum="594E40F8132D66F9" modified="2024-10-02" version="1">MTGPVETPIGPRSLADMCLTLAIDNIRHIVSLGDLPRHLTDPLLNAVKTAEQLHTLELNSDDIYDETPSHWIRIISRDFPALARRHNYAPQNPKSWHKVYDKYKKLEEEEIAAATEKLSKQLAARTEQKQSRAATIISAEEGGKLRRTRAQPGFTSRAPKGSFIQQTRKQLRVESRRFNLPTPTGQLYVPPGQIKKVPDFMVEDARRRELSSQAIRPPPPLNWGRGPSGIVQDREGKEAQTASARDREEREARLLKIKNAGQSKAGTTGNILSFSDDEDDAEVVDLTGGPEAEDADLFGGLGPDEDLFGDVVPKKTVSSASSSSRKGPPPPPTANQAAKRRRSIEAKAPEQPAKRRRGLEETTTSASSAPKTARVTPPPTANPSLKRRSTGLSAAPGANRGLQPPPKPVSKTTAKSNASSRPSVAPTVDDQPPRSHPLTTPRDARHPFPKPGQGNPRGALSQTGPFTFVEDETPTEEDTTRRSQAPAQKPKRPYVYPVCRPPARLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PI31</accession>
    <name>A0AAN6PI31_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Galactose oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_15646</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854376">
        <property type="protein sequence ID" value="KAK4040498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PI31"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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            <end position="20"/>
        </location>
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        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK4040498.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="352" mass="37181" checksum="905FF5503990F175" modified="2024-10-02" version="1">MKSVTQTLGFLAALQGVLVAGSPCNSPSPHWKTLSPIALYPRQEHTTLALNRTTLAILGGIVPNGLPTQFNTTSLLQLYSIPTNKWHPAPLAPMPVALNHPNAAAVDGKIYLLGGLDDRGDGIWRGTGRSWVYDPTTNTWAELPGIPDVPRGSAAMGVDERTGVVYLAGGMTQLPLIEGAGEQESVDVVSAFDTRKGEWVAALPAGVKAMPGRRDHAGAVVVDRVMYVLGGRDRGQHNVRGDVFALDLGRLGKGWVTKAGKMPTPRGGVCAGAVAGKVYVFGGEGNPVEGSDGVFDQVEAYDIRKDTWERLDKMELPRHGTSAVAVGRGVYIPGGGIKLGGAPVDTFNVFYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PI35</accession>
    <name>A0AAN6PI35_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_46994</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854397">
        <property type="protein sequence ID" value="KAK4039586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
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    </dbReference>
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            <end position="178"/>
        </location>
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        <location>
            <begin position="1"/>
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    </feature>
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        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
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        <location>
            <begin position="28"/>
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        <location>
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            <end position="73"/>
        </location>
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        <location>
            <begin position="100"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4039586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="694" mass="74406" checksum="2EC8A230770CFC49" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PIB8</accession>
    <name>A0AAN6PIB8_9PEZI</name>
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        <recommendedName>
            <fullName evidence="5">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_15538</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854373">
        <property type="protein sequence ID" value="KAK4040633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PIB8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38166:SF1">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38166">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042873115" description="C2H2-type domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="562"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="678"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="819"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="468"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="684"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="834"/>
            <end position="857"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4040633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="934" mass="101672" checksum="F0271E59D40B2593" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PIT4</accession>
    <name>A0AAN6PIT4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Pyruvate dehydrogenase E1 component subunit alpha</fullName>
            <ecNumber evidence="9">1.2.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">C8A01DRAFT_45831</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + pyruvate + H(+) = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:19189"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10478"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="1.2.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat MET30/SCONB/SCON-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.1" evidence="9"/>
    <dbReference type="EMBL" id="MU854367">
        <property type="protein sequence ID" value="KAK4040903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PIT4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02000">
        <property type="entry name" value="TPP_E1_PDC_ADC_BCADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000013">
        <property type="entry name" value="Pyruvate dehydrogenase E1 component subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050642">
        <property type="entry name" value="PDH_E1_Alpha_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017597">
        <property type="entry name" value="Pyrv_DH_E1_asu_subgrp-y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03182">
        <property type="entry name" value="PDH_E1_alph_y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11516:SF60">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11516">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT, ALPHA SUBUNIT BACTERIAL AND ORGANELLAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7 9" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 9" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="3 8" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="11">
        <location>
            <begin position="132"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="312"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="352"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="393"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="433"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="473"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="513"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK4040903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1081" mass="119323" checksum="FA2B0CB7C6AD611B" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PIT9</accession>
    <name>A0AAN6PIT9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Xylosyltransferase oxt</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_34526</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854357">
        <property type="protein sequence ID" value="KAK4041442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PIT9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="3">
        <location>
            <begin position="170"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="121"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4041442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="270" mass="28975" checksum="905D7866144A129E" modified="2024-10-02" version="1">MLDDGANLPIPNRERNNGGSLIVYHGHHGFNGAHPHQPWRKPSSETDDDPAKLESCRLVSPTPPPPERKFFNLTLPTFILSCVLLVVTAALIILGGILGSKITTLENTIPSLTSITNPLGSPTSANETASNNNTNTTNNNTSQSSSSSSSSSNNPGSTTTPTPPTILISGWTYRGCYYDSEVRVLPDAFLSAMNMTNGVCAEFCSSDGRRSQHFGTQVALQCYCGSASAAVLASRRAPDWACEQQCRGRGSMREYCGGDWTLSLWERDGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PJ35</accession>
    <name>A0AAN6PJ35_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7136 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_34038</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854349">
        <property type="protein sequence ID" value="KAK4041928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PJ35"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055560">
        <property type="entry name" value="DUF7136"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23584">
        <property type="entry name" value="DUF7136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7136" evidence="1">
        <location>
            <begin position="5"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4041928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="231" mass="24441" checksum="3E890F7C97FAFDB4" modified="2024-10-02" version="1">MHVGWTISEIGGNRGTFGSLRLRCDELGQSDPFFTSEFMDWAQTTDSEATWNFIWDVQSQNCSGTDNYKQISQILQTRQVIFTTKKGAQQPDVLQGTSACARSPGVTFNVTDTMSIDASSNLGRDSCNVLAPGPSPVANVCAIAMGPAVAATATKITPQSLCESVGTTASSTTTAHGNAAARGRAALGRGCWVHVVGITLLRGRCAGRIVLGSVQSPISESRVAGRLDFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PJ42</accession>
    <name>A0AAN6PJ42_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNase T2-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_47057</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854399">
        <property type="protein sequence ID" value="KAK4039490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PJ42"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057328">
        <property type="entry name" value="RNaseT2L_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25488">
        <property type="entry name" value="RNaseT2L_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042894688" description="RNase T2-like C-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="RNase T2-like C-terminal" evidence="2">
        <location>
            <begin position="34"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4039490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="174" mass="18772" checksum="856AEB27D7E62953" modified="2024-10-02" version="1">MLSLPALLLTLTAALAAPTSTPTKDFSGYGQLRTLYIHDDHEDLGCLTAVGKWTADESQCGIFVAEQLPAPPQVLSNFQLSAPGIGNCGIEVATFKCGEDVKPVTFGTWGTKGPVPGRDVLRYSQYGVFATNAADSPPALKDEALDIHFYSGAEKGKWVWLGWEFLFDIDSDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PJV5</accession>
    <name>A0AAN6PJV5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Tubulin beta chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">C8A01DRAFT_33536</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4 13">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the tubulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854342">
        <property type="protein sequence ID" value="KAK4042333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PJV5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097435">
        <property type="term" value="P:supramolecular fiber organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02187">
        <property type="entry name" value="beta_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000003">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000002">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000009">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013838">
        <property type="entry name" value="Beta-tubulin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002453">
        <property type="entry name" value="Beta_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01163">
        <property type="entry name" value="BETATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00228">
        <property type="entry name" value="TUBULIN_B_AUTOREG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="15">
        <location>
            <begin position="47"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="16">
        <location>
            <begin position="246"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="422"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="429"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAK4042333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="447" mass="49967" checksum="62150C55E96F91DE" modified="2024-10-02" version="1">MREIVHLQTGQCGNQIGAAFWQTISGEHGLDSNGVYNGTSELQLERMNVYFNEASGNKYVPRAVLVDLEPGTMDAVRAGPFGQLFRPDNFVFGQSGAGNNWAKGHYTEGAELVDQVLDVVRREAEGCDCLQGFQITHSLGGGTGAGMGTLLISKIREEFPDRMMATFSVVPSPKVSDTVVEPYNATLSVHQLVENSDETFCIDNEALYDICMRTLKLSNPSYGDLNYLVSAVMSGVTVSLRFPGQLNSDLRKLAVNMVPFPRLHFFMVGFAPLTSRGAHSFRAVSVPELTQQMFDPKNMMAASDFRNGRYLTCSAIFRGKVSMKEVEDQMRNVQNKNSSYFVEWIPNNVQTALCSIPPRGLKMSSTFVGNSTAIQELFKRIGEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDAGVDEEEEEYEEEAPLEHEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PJZ6</accession>
    <name>A0AAN6PJZ6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxalate oxidase GF-3.8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_45330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854356">
        <property type="protein sequence ID" value="KAK4041473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PJZ6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02231">
        <property type="entry name" value="cupin_BLL6423-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047142">
        <property type="entry name" value="OryJ/VirC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36156:SF2">
        <property type="entry name" value="CUPIN TYPE-2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36156">
        <property type="entry name" value="SLR2101 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-2" evidence="2">
        <location>
            <begin position="109"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4041473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="209" mass="22344" checksum="DDC1401D4C7C123B" modified="2024-10-02" version="1">MSSNPDSQAPQTPFGAPNRYTTTHDPATHKSVFSRALPEPLTGYGAAGMAVFDSYKTFTHPFNMTGESDIAALQAHPSSQSPSLSPAAAGPPNGKIWFPAAGETLLRYCDWAPGRTIPFHRTETLDLGVCVAGRMELTLDSGEVRVLGVGDTIVQRGTMHAWRNPSETEWARVVFFLLGAEPVQVGGEVMGEVLDWSGAGEGKAKAKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PK46</accession>
    <name>A0AAN6PK46_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_16142</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the importin beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854388">
        <property type="protein sequence ID" value="KAK4039925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PK46"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051345">
        <property type="entry name" value="Importin_beta-like_NTR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12363:SF33">
        <property type="entry name" value="IMPORTIN-13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12363">
        <property type="entry name" value="TRANSPORTIN 3 AND IMPORTIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4039925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1026" mass="113431" checksum="3A79575862762E49" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PKY4</accession>
    <name>A0AAN6PKY4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RTA1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_46223</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854377">
        <property type="protein sequence ID" value="KAK4040405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PKY4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF32">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="275"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="290"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4040405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="301" mass="32833" checksum="AEEA834DFCA95825" modified="2024-10-02" version="1">MADEPTSIWMYNPSFALAVLGSVLYGLVFIWIFYLTVIRHRAWFLTCVVIGAAIEVAGYGLRCYSIKKQADVGPFAATLTLVVLAPVFVAAGNYLLIGRLVRAVLDPATTGHRVFGVHGRLITRIFVICDVVSCLVQAGGSSVASSTEWVGSTADIGIWILIGGLVLQAVAFVFFMAIFARFHYIASNKGLVAEDAPAGWERLVVAVYVSSSLILVRCIYRIAEFAEGAEGYAFLHEWMFWVFESLPMLIAIGVFCVWHPSAYLGRDGGRARIRGKAGEAGDSEEAATELRSSYRSSRQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PL74</accession>
    <name>A0AAN6PL74_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_44041</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854333">
        <property type="protein sequence ID" value="KAK4042971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PL74"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025337">
        <property type="entry name" value="Questin_oxidase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35870:SF6">
        <property type="entry name" value="MGS207 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35870">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G03330)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14027">
        <property type="entry name" value="Questin_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4042971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="399" mass="44464" checksum="929CCDC65155D83C" modified="2024-10-02" version="1">MAKHGSRAVFDGLLAKTHVQHALVQLDGQYNQLPSALATLFFLDGTPDQLQATYDSMKGDLAAWEPSPRGIADEEAKSRFLGDVRFQRAFMTYFSMENGRFAGNSKSLAICHVFTGDKPLIYGLFSGIGRPLSLLADGIELRTAILVMESLTLSAVDWMEPMRELLTHPQLAVPPGEYLSPEDIIGRVGYDGRFSGVMKAGPGFHGVSHVFSNPNARAAIVEYMRCLDTRDLTQVLQQVSVLSALLVSAAHKPNQPAFDLYLSRLPTCVNSVRVMLENWVEDEGHKLILVRGLWLLVILTYITQLRPVIDTKLLVSKELAEEHRGWEALFEQVLGQGASEGEHGDLNLLRALRSLRELSKAYDVVHGKLYFHAAWKLANKWRGWTGLGLDREVMLNIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PLN6</accession>
    <name>A0AAN6PLN6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pre-rRNA-processing protein RIX1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_32715</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RIX1/PELP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854330">
        <property type="protein sequence ID" value="KAK4043226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PLN6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012583">
        <property type="entry name" value="RIX1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34105">
        <property type="entry name" value="PROLINE-, GLUTAMIC ACID- AND LEUCINE-RICH PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34105:SF1">
        <property type="entry name" value="PROLINE-, GLUTAMIC ACID- AND LEUCINE-RICH PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08167">
        <property type="entry name" value="RIX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pre-rRNA-processing protein RIX1 N-terminal" evidence="6">
        <location>
            <begin position="6"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="464"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="630"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="476"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="631"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="681"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="698"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="721"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="773"/>
            <end position="789"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4043226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="789" mass="85337" checksum="B8802B9C3B093DE1" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PLX3</accession>
    <name>A0AAN6PLX3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_14754</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854356">
        <property type="protein sequence ID" value="KAK4041504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PLX3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4041504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="227" mass="24220" checksum="9D13758655739CF4" modified="2024-10-02" version="1">MTGRGPGKEQLEDIAQQAQRDLNTYQAKTGTGKGRTTGLDDYGVNDTVDKKFPGASVKVGENLVTNRSYDRRIPADEGGAVDETGRFVRGSAFEGAGGPEEKTAHVYQHNLGKVEEATVRGWGMEPHKLERATLRSDRPDLLPADQALGGRGREPARKGDVSEQGRAAAKANVGLAAESRGEVPAQGSGGGSQFKGEYYEAPESVPDQRADQNEVPPETVTETSKII</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PM15</accession>
    <name>A0AAN6PM15_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_43633</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854327">
        <property type="protein sequence ID" value="KAK4043509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PM15"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="107"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="280"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4043509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="321" mass="34252" checksum="40DD0440E386BA43" modified="2024-10-02" version="1">MESVFSDAEKRFLLAEMIKLSQMDVGLLVDFAKSHGIQPDWLRMQLPGGRNMSQCLHAAEDMFDMPMPPPSLVSAPKRKSLGDLPDDGPNKRQAVASPGLVSPHGFPLGPAIQPAPGAQPVNILPRPNGYAPGPPVPAPSVAPYNPAPAPRRRGRPSKASQNTWQVSTSPNTPAPIAPSPASAPAPQPQSPGLHPPNPKRPKKGLPEIAPRPAQGLPAIEPAGRSPAVPGPEYQAWRDETNHREYYQVQAADPPARERPASTYTSILPRPPLPPPRELTHPASAHPASAEPRHFTATPPLPSAPEPVKEESQPASTEPIKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PM63</accession>
    <name>A0AAN6PM63_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_12894</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854326">
        <property type="protein sequence ID" value="KAK4043623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PM63"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF26">
        <property type="entry name" value="AXIAL BUDDING PATTERN PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="235"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4043623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="338" mass="34339" checksum="C2346B7F61A38472" modified="2024-10-02" version="1">MSVTATNPTVGTIDGTAIVFYPVPTPWPASAGCDQYVYRQLAAGPIIAWDPVYPQIFETAAQSCYPPQQSSWWSQASSAEPSTALGPTFVCPESYSAVHSTVVESNSASQAQYTYCCPPYRSIIQCTSTAAPGETISLQSVTWLTSSVTTTGDNGSVTRKATSQLTNVATSTVVRSSAATVFAPPVNGYNIVQRQASSTGTGTGATTSNTATAGTTLSSQSSAASDAASTESSGLAAGAIAGIVVGVVGGLALLALGVFFFLRRRRRYAAVAQPDVAAAAGGAYTAGGAYTAGGAYTPGGGAAPKYYGSEAHEMPVGTQAQELGHAVYDAHELPAGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PML1</accession>
    <name>A0AAN6PML1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_32322</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854326">
        <property type="protein sequence ID" value="KAK4043592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PML1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4043592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="71" mass="8227" checksum="0DCF152DBB25676A" modified="2024-10-02" version="1">MPRWEDIREDLFEAIIQVHPAINKEQQAEIVEIMKAKGHDMGWNAIRYVLFSCSASWFPQPGKEAFLPVVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PNN7</accession>
    <name>A0AAN6PNN7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">C-4 sterol methyl oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_32521</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854328">
        <property type="protein sequence ID" value="KAK4043395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PNN7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="5">
        <location>
            <begin position="146"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4043395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="306" mass="35593" checksum="955F539BB5C9B6EF" modified="2024-10-02" version="1">MASAVMNSTIAGLSSSASITTVFEEVSKYNVQLNVFERLWASWYLWMQNDTIATGIMSFVMHEFVYFGRSLPWMIIDAIPFFNKYKLQNTKVPTWKEQWECAALVLLSHCTVELPQIWLFHPVATYFGLDYGVPFPPAWKMAMQIAVFFIVEDAWHYWFHRALHYGPLYKNIHKLHHTYSAPFGLAAEYASPIEVMLLGFGIVGTPIIWVSLTGELHLITMYLWIVLRLFQAIDAHSGYDFPWSLRHILPFWAGADHHDMHHERFIGNYASSFRWWDYCLDTEAGEAASKKRREKKLAEIRAKKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PNP2</accession>
    <name>A0AAN6PNP2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UBX domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_44829</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in endoplasmic reticulum-associated protein degradation (ERAD). Acts as a platform to recruit both UBQLN1 and VCP to the ER during ERAD.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Directly interacts with VCP. Interacts with UBQLN1. Forms a complex with VCP and UBQLN1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854345">
        <property type="protein sequence ID" value="KAK4042181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PNP2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006986">
        <property type="term" value="P:response to unfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01767">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46424">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46424:SF1">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23187">
        <property type="entry name" value="UBX7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00166">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0834">Unfolded protein response</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="388"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="UBX" evidence="8">
        <location>
            <begin position="278"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="111"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="417"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="117"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="131"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="183"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="417"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="446"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="457"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00041575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00046062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4042181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="475" mass="51370" checksum="122AAE87AFB4818F" modified="2024-10-02" version="1">MAFFQGTLQEGIAAALQQAKSVVCFVTDGEAESQLWEDDFFAEEEIRSLLPTHAVSLRLVAGSQEEGFLSQLYPIPKRPTVVIIRNGELKEYIAAGVIRDEFVRRLKTSLTAERPAPSQPLPSQPAPPQPQIMAAPAPSATQPSHAEESSASSSGQSTPPSPTGSRMQSLLAERAASLIQQQKKKDQEEAARQHAEKAKAEALASKKTAEQSKHAAALKKQQQEAREERERILKAIEDDKVARKAQQAEAAAARRLSVASEKPDAAQLVVPPPAAAGKFSEHCAIQVRLFDGSTIRHRFSSSETLKDVRKWVNETRGDGKAAYTFKVLLTPLPSKTIDVAEEDKTLQALELAPSSTLILLRVPKFAATYSASARPVAGEAQGSAFQRFVAYVLAIITGFFSTVSAFFSTLFSTAGPPAASEPSTSQTSQSQPAADAARRRGGRIAGMDHMDGRRNDQQFYNGNSTNFEPRSDDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PP38</accession>
    <name>A0AAN6PP38_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cellulase</fullName>
            <ecNumber evidence="3">3.2.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">C8A01DRAFT_42807</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.4" evidence="3"/>
    <dbReference type="EMBL" id="MU854319">
        <property type="protein sequence ID" value="KAK4044372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PP38"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000078">
        <property type="entry name" value="Endo-beta-1,4-glucanase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34142">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34142:SF1">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 9 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042857691" description="cellulase" evidence="11">
        <location>
            <begin position="17"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="12">
        <location>
            <begin position="16"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK4044372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="393" mass="42134" checksum="E9E275B7951B33F6" modified="2024-10-02" version="1">MKSSILAGVFATGAVAQSGPWGQCGGNGFQGSTSCVSGYQCVYQNDWYSQCLPGTAAASTTLKTSTTAKPSATSSSAPATSSSPSSGNGKFKWFGVNQSGGEFGEGNYPGTWGKHFIFPSSSAIQTLINDGYNIFRVGFSMERLVPNQLTSSFDDGYLRNLTETVNFITNAGAYAVLDPHNYGRYYGNIITDTNAFTSFWTKVGKQFAANSRVVFDTNNEYNTMDQTLVLNLNQAAINGIRAAGATSQYIFVEGNQWSGAWSWNTTNTNMAALTDPQNKLVYEMHQYLDADSSGTNAACVSAEIGVQRVVGATSWLRANGKVGVLGEFAGGANSVCQSAVTNLLEHLKANSDVWTGALWWAGGPWWADYMFSFEPPSGTGYVNYNSLLKKYVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PPH9</accession>
    <name>A0AAN6PPH9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Probable beta-glucosidase btgE</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Beta-D-glucoside glucohydrolase btgE</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Cellobiase btgE</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Gentiobiase btgE</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">C8A01DRAFT_12050</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854318">
        <property type="protein sequence ID" value="KAK4044547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PPH9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050732">
        <property type="entry name" value="Beta-glucan_modifiers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631:SF24">
        <property type="entry name" value="FAMILY 17 GLUCOSIDASE SCW11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0134">Cell wall</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043038656" description="Probable beta-glucosidase btgE" evidence="14">
        <location>
            <begin position="20"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="220"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK4044547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="523" mass="53839" checksum="90B66CC7E58D446A" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PPL7</accession>
    <name>A0AAN6PPL7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EthD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_32003</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854323">
        <property type="protein sequence ID" value="KAK4043905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PPL7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4043905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="180" mass="19676" checksum="257F73FBD1ADB23D" modified="2024-10-02" version="1">MARPGIIIVTSRPTAADFTADDLNKWYLKKHIPDVLATDGVQAALWCQLTALAGQVDEQAPPAPYLAVYYLPDLDWLHKEKCGFWKLPMELDAEDGRKGLKIFDVAEFSTASWELDAGLQLTGPTPRWPVTPGGDEEAIASSITGAEILGYTVLLQFGDTRIKGLQNGGSYPVFGNGYFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PPV3</accession>
    <name>A0AAN6PPV3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mitochondrial import inner membrane translocase subunit TIM22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_30973</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the TIM22 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Tim17/Tim22/Tim23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854316">
        <property type="protein sequence ID" value="KAK4044792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PPV3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042721">
        <property type="term" value="C:TIM22 mitochondrial import inner membrane insertion complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030943">
        <property type="term" value="F:mitochondrion targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039175">
        <property type="entry name" value="TIM22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14110">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14110:SF0">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4044792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="219" mass="21079" checksum="FC31DB9E93F37519" modified="2024-10-02" version="1">MNFPGSGGSGLGGLGGLGGMGGGAGAGGVPGIPSVGGNAGAPAPPGFDPNDPNVKWLTNAMESCYAKTAMSGVAGFALGGLFGMFMASMAYDTPFHTPGAPGAPGGVPGIPGSAAASATTISSLPLRKQLAHGFKDMGARSWSTAKNFGAVGALFSGIECGIEGLRAKNDIGNGVAAGCLTGAILARNGGPQAAAVGCAGFAAFSAAIDAWMRMPKDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PPY6</accession>
    <name>A0AAN6PPY6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_43905</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SH3YL1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854331">
        <property type="protein sequence ID" value="KAK4043124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PPY6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11842">
        <property type="entry name" value="SH3_Ysc84p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11525">
        <property type="entry name" value="SYLF_SH3YL1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000100">
        <property type="entry name" value="SH3 domain-containing YSC84-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051702">
        <property type="entry name" value="SH3_domain_YSC84-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033643">
        <property type="entry name" value="SYLF_SH3YL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007461">
        <property type="entry name" value="Ysc84_actin-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629:SF2">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING YSC84-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629">
        <property type="entry name" value="SH3YL1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04366">
        <property type="entry name" value="Ysc84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01887">
        <property type="entry name" value="SPECTRNALPHA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="344"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="245"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="261"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="314"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4043124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="404" mass="42127" checksum="0B4702A3FDCA5E8C" modified="2024-10-02" version="1">MGINNPLPSSMASECKKCAKILTSFIDPRQAFGPEKVIPPSVLANAKGLAILTVIKAGFLGSARFGSGLVIARLPDGSWSAPTAIATGGAGFGGQIGFELTDFVFILNDASAVKTFSQAGSLTLGGNVSIAAGPVGRNAEAAGAASLRSVAGIFSYSKTKGLFAGVSLEGSAIIERKDANAKLYGRQVSAKELLSGGERPPPQAAPLLTILNSRVFRGMATASAGDSMYNDVPVYDDHHDNVVWGGNTGPGYREGQSRDGPGVGAGGGGQAHDEFGRPKRSSTWQDDVYDPQPRGGFGQASRSSTFHDSSFGGESRDGPTTEKRAGPGRPAAPKPNYASKEALLKKNEAVALFNFEADQPGDLGFKKGDVITVLKKTESDNDWWTGMIGTKHGIFPSNYVKLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PQD3</accession>
    <name>A0AAN6PQD3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Armadillo-type protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_13720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854337">
        <property type="protein sequence ID" value="KAK4042685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PQD3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006409">
        <property type="term" value="P:tRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051177">
        <property type="entry name" value="CIK-Related_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984:SF3">
        <property type="entry name" value="N-TERMINAL KINASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984">
        <property type="entry name" value="SCY1-RELATED S/T PROTEIN KINASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="551"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="601"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="776"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="555"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="620"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="656"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="701"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="777"/>
            <end position="786"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4042685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="795" mass="85650" checksum="9C4B4EB3198F0B4C" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PRI7</accession>
    <name>A0AAN6PRI7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_31149</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854317">
        <property type="protein sequence ID" value="KAK4044653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PRI7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4044653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="267" mass="30773" checksum="F2E37A6660C1D731" modified="2024-10-02" version="1">MPELHEVSYSREATVAAVREYYCFLTRMYLKECYVAEPPEWGWPEINPETLGVLGKTDEVISLLRHLLYIQSSDDSALGAAVCLFADWRDVARSASLGQLSVGDVGVTTEHELPKPMYPHVVGLTHGGYYNPAFLLDTKLGIVYWHECHSDIKRNPSREPIGGEEYDGYDDISWDEADWRSDSVAWSISDFFELLKDLFRRLFYVPISPRKVCFASAMKGMPMLAAIYRAHCWPDLERYHKQDCLKAVQDLMEERYPDDADRREKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PRJ4</accession>
    <name>A0AAN6PRJ4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_32159</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854325">
        <property type="protein sequence ID" value="KAK4043636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PRJ4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002410">
        <property type="entry name" value="Peptidase_S33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051601">
        <property type="entry name" value="Serine_prot/Carboxylest_S33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248">
        <property type="entry name" value="2-SUCCINYL-6-HYDROXY-2,4-CYCLOHEXADIENE-1-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248:SF2">
        <property type="entry name" value="PROLYL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00793">
        <property type="entry name" value="PROAMNOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="73"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4043636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="479" mass="53375" checksum="C90F97BB20A852D1" modified="2024-10-02" version="1">MAAVKAARLLSRRAHVLPGQLHVTELFFEVPKNHARPEAGTLTLFGRSVRKHERPIVPLSAADLASKEKLPYLVYLEGGPGFGNREPQNHALTQVALSRGYQVLYLDYRGTGLSTPVNADSVVAQGGAQKQADYLKLFRATSIVRDLEAVRLCLTEDFDEDKKTWSIFGQSFGGFVGLTYLSKYPKGLREAFLTGGLAPVKRTADEVYTATYKKLTERNAAYYKKYPEDIPAVRRLTDYIHWLHLEGTGIPLPSGGNLTVPLFLTLGLAFGGHGGLDEVHSLILRLATDLGQFRKFTRASLAAFESHISFDTHPIYAILHEAIYNTKQKGAPASDWAAYRVGRALKPFAWLDDAPAFLQSTPATDPLYFSGEMVYPFHFDGTTGPELARLKEAADILAATDEWDEDLYDEAQLRRNNVPVYAVSYVDDMYVDFELARETAALVRGIKVRETNGWYHDAVRSKSEEVFAALFKLRDDCVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PRU8</accession>
    <name>A0AAN6PRU8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_12379</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854321">
        <property type="protein sequence ID" value="KAK4044144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PRU8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000050">
        <property type="entry name" value="GTPase activating protein (Gyp3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF20">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="572"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="640"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="885"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="469"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="646"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="889"/>
            <end position="907"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4044144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="963" mass="106694" checksum="60A9B22CC3E1CB61" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PS97</accession>
    <name>A0AAN6PS97_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">C8A01DRAFT_42794</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class I-like SAM-binding methyltransferase superfamily. BUD23/WBSCR22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854319">
        <property type="protein sequence ID" value="KAK4044354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PS97"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016435">
        <property type="term" value="F:rRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070476">
        <property type="term" value="P:rRNA (guanine-N7)-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000017">
        <property type="entry name" value="probable 18S rRNA (Guanine-N(7))-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039769">
        <property type="entry name" value="Bud23-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022238">
        <property type="entry name" value="Bud23_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12734:SF0">
        <property type="entry name" value="18S RRNA (GUANINE-N(7))-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12734">
        <property type="entry name" value="METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12589">
        <property type="entry name" value="WBS_methylT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="9">
        <location>
            <begin position="52"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="18S rRNA (guanine(1575)-N(7))-methyltransferase Bud23 C-terminal" evidence="10">
        <location>
            <begin position="209"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK4044354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="280" mass="30206" checksum="A95ABE2C49A869BA" modified="2024-10-02" version="1">MSRPEDTLAADVHYDDVEARKYTTSSRIQNIQASMTQRALELLDLKSPSLILDIGCGSGLSGEILSAVPEDEGGPHVWVGMDVSASMLDVALQRDVEGDLLLADIGQGVPFRAGAFDAAISISAIQWLCNAENSETSPAGRLSRFFNGLYASLKRGGMAVCQFYPKNDVQKQMITSAAVKAGFGAGLLEDDPDTKNVKVYLVLTVGSSAMANKGGDITGVVDGMDNVDVMDHRRKGKSGKGDIKKGSKAWIVKKKEQMERKGKIVKSTSKYTGRKRRIQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PT60</accession>
    <name>A0AAN6PT60_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Pre-rRNA-processing protein esf1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_12485</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ESF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854321">
        <property type="protein sequence ID" value="KAK4044110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PT60"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039754">
        <property type="entry name" value="Esf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012580">
        <property type="entry name" value="NUC153"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056750">
        <property type="entry name" value="RRM_ESF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12202">
        <property type="entry name" value="ESF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12202:SF0">
        <property type="entry name" value="ESF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08159">
        <property type="entry name" value="NUC153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25121">
        <property type="entry name" value="RRM_ESF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ESF1 RRM" evidence="7">
        <location>
            <begin position="177"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="NUC153" evidence="6">
        <location>
            <begin position="632"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="73"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="222"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="409"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="445"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="471"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="643"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="83"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="243"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="412"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="488"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="516"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="551"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="590"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="603"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="661"/>
            <end position="694"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4044110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="713" mass="80593" checksum="E492FEDF785E0263" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PTX5</accession>
    <name>A0AAN6PTX5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptidase S54 rhomboid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_42697</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854318">
        <property type="protein sequence ID" value="KAK4044515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PTX5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050925">
        <property type="entry name" value="Rhomboid_protease_S54"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43731:SF14">
        <property type="entry name" value="PRESENILIN-ASSOCIATED RHOMBOID-LIKE PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43731">
        <property type="entry name" value="RHOMBOID PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="310"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="340"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="377"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="426"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="453"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="493"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="9">
        <location>
            <begin position="390"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="252"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="252"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4044515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="566" mass="61826" checksum="E74EFDEB8709D156" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PTY7</accession>
    <name>A0AAN6PTY7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Clathrin light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_31006</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasmic vesicle membrane</location>
            <topology evidence="1 6">Peripheral membrane protein</topology>
            <orientation evidence="1 6">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <location evidence="6">Coated pit</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="6">Cytoplasmic face of coated pits and vesicles.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the clathrin light chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854316">
        <property type="protein sequence ID" value="KAK4044821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PTY7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030132">
        <property type="term" value="C:clathrin coat of coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030130">
        <property type="term" value="C:clathrin coat of trans-Golgi network vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032050">
        <property type="term" value="F:clathrin heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000996">
        <property type="entry name" value="Clathrin_L-chain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10639">
        <property type="entry name" value="CLATHRIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10639:SF7">
        <property type="entry name" value="CLATHRIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01086">
        <property type="entry name" value="Clathrin_lg_ch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0168">Coated pit</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 6" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="3 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="49"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="133"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="14"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="50"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4044821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="238" mass="26047" checksum="0726FF937BAA2AA4" modified="2024-10-02" version="1">MADRFPSLEDFDSGAQTDVRNTTDVPSTTNFLEREKAILGDDANQFATVEDADFDDGDDDLLGGGGGVSSPGNNAAFESQFPDITSPNEGVAPGGTITGPTVSYNSGYQAYTEEEEEPEVIKEWREKRDAQIAKRAEQFAQQREETVREAQQNIDDFYENYNNKKEKMVAQTRKDAEQFLASREDTTSGGTSWERISKLVDVSGKGAKGGAAGSGKERFRELLTSLRKDEKAPGAEGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PU04</accession>
    <name>A0AAN6PU04_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="14">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">C8A01DRAFT_31349</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="14"/>
    <dbReference type="EMBL" id="MU854318">
        <property type="protein sequence ID" value="KAK4044560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PU04"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23285">
        <property type="entry name" value="beta-trefoil_MIR_PMT4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000044">
        <property type="entry name" value="Dolichyl-phosphate-mannose-protein mannosyltransferase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="ArnT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="PMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050:SF51">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 14 17" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="600"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="638"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="726"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="333"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="401"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="465"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAK4044560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="775" mass="88163" checksum="8A45BC4FAD2DAF65" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SK80</accession>
    <name>A0AAN6SK80_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_21345</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854817">
        <property type="protein sequence ID" value="KAK4031421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SK80"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4031421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="73" mass="8127" checksum="92427E2E84377862" modified="2024-10-02" version="1">MHLGAWAPLAHGAIHNLFVGNLLPPASIYGLEFNDETNDFKIIKNHTADASHAWITFDVKPLRPPSYPMLLGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SKE2</accession>
    <name>A0AAN6SKE2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycosyl hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_41932</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854746">
        <property type="protein sequence ID" value="KAK4031616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SKE2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04081">
        <property type="entry name" value="CBM35_galactosidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18821">
        <property type="entry name" value="GH43_Pc3Gal43A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22925">
        <property type="entry name" value="GLYCOSYL HYDROLASE 43 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22925:SF3">
        <property type="entry name" value="GLYCOSYL HYDROLASE FAMILY PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042847164" evidence="6">
        <location>
            <begin position="19"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="4">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4031616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="451" mass="49213" checksum="C8580DBD7FCB01C4" modified="2024-10-02" version="1">MRFLSIALTAALSSLATASLQVVPGGTWTTSNSEPLQAHGAGLIQVDGVYYMVGEDKSGGSSFENVNCYSSKDLVQWTYVGALLSRTSSGDLGPNRVVERPKVIYNDKTRKYVLWMHMDSSSYGEARVAVASGDSVCGKYTYHRSFQPLGRESRDMGLFKDDDGKGYLLTEDRNYGLRIVALSDDYLSPTSDVYSWKLEGGNRVEAPAMIKLGNTYFMFASMMTGWDANENQYTTSTNLRSGWSGWKKFADSGSNTYNSQTTYILKTSESSAIYMGDRWLKDNLQASTYVWLPLSISGTSVQMKNFVSWVPTSNFANWQNPPAETSYEAEKATYGGKARNVDCSVCSGKVAAGYIGGPDKGTVTFNNIRSDIDGLTTIRIKFLNGDSGPRYANVRVNGDGGRKVAFLSARGDPASSTLHANLKKGSGNTIVIEGIDNGWGPDIDRLMVPVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SL69</accession>
    <name>A0AAN6SL69_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">N-terminal acetyltransferase A complex catalytic subunit ard1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_50738</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. ARD1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854606">
        <property type="protein sequence ID" value="KAK4032471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SL69"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031415">
        <property type="term" value="C:NatA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990189">
        <property type="term" value="F:protein N-terminal-serine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990190">
        <property type="term" value="F:protein-N-terminal-glutamate acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045047">
        <property type="entry name" value="Ard1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23091">
        <property type="entry name" value="N-TERMINAL ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23091:SF4">
        <property type="entry name" value="N-TERMINAL AMINO-ACID N(ALPHA)-ACETYLTRANSFERASE NATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="5">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="170"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="170"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="195"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4032471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="247" mass="27779" checksum="4D6A7AFC31AD9748" modified="2024-10-02" version="1">MDIRLLRSSDIPLIQHANLENLPENYFLKYYLYHALSWPQLSYVAVDVSRPPKTPYDYPKIVGYVLAKMEEEPSDGVQHGHITSLSVMRTHRRLGIAEKLMRQSQQAMVETFGAHYVSLHVRVSNKAAIHLYRDTLGFKTEKTESKYYADGEDAFCMKLELDFIRDQLREEDGGEGEGKDKKKQQKKKAAKEGEAEAEAEDADEGEPVGDVGSDPARGNKGGQKIKVKVGRGLGVGELIEKDESKHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SM93</accession>
    <name>A0AAN6SM93_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heterokaryon incompatibility protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_41043</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854601">
        <property type="protein sequence ID" value="KAK4032503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SM93"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF73">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G01020)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26639">
        <property type="entry name" value="Het-6_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="57"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4032503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="661" mass="73789" checksum="73553B6666971683" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SMC2</accession>
    <name>A0AAN6SMC2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_50632</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854591">
        <property type="protein sequence ID" value="KAK4032607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SMC2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4032607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="269" mass="26070" checksum="F582ADF0DD2AEE2C" modified="2024-10-02" version="1">MPPIQVYTKSPINAAKASGITPETAALAAAADSNPANPPAHPTSTTTTTTTTTTAYQPSPNNPTPTRTIPPQQRPPPPQPGAVPRLPEATGTSTAPSSSLPPPPRAGAFAGSTGAGDGGGPAPPAPTAAPALTAGGVSYPPPPPQMAIPPPQAGGYNQRGTSTAMASNFGTAAATGTGVAGPWGAAGGGGASQGYPGLVVGSVSGPAGYQQNVSASGSGYQWGGGGNGEEEDDEEGILGSAMKFAKAAGEKLSAAESEVWRRINGEGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SN99</accession>
    <name>A0AAN6SN99_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_49841</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854520">
        <property type="protein sequence ID" value="KAK4033597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SN99"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="275"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="349"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="91"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="364"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4033597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="407" mass="46265" checksum="EA31C0E8308D2E90" modified="2024-10-02" version="1">MSGLEVIGLVISAIPIVTRVVKHFGTQRNAPRQLERLSRMLAELRDERLLQAAMPAEQKHIHEMVNRCTDLLEKENATAGQKGRTWNFFWSAEAENRLKAHNDELERELDRLERRVHMYHAMLVASPSALGPRLSTNMPYIPRGNIWFEDEDLEDVSVSFLEAHDITIQNSEGYKVYRSYSLYQFGTVEHREEFLVHVRERQLLGRYFAEKIWEKGELIAQQKVVRLWKKTARGESQKTTLSFIGRDEKPYERPLVDFSRSPTLRKNRVDLVAGSSKTTLEFRRPPNQPKRGSGLFGRRSRASTSSTSEGGADDSDAARFKATFEASHPATSTFKPLTWTPTVLEPLTDFEDPAATSPRLPGLTPSTSRAPTLSTMSVPSASIYFPSDDHRVSPRSSMATKDEVSFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SNI6</accession>
    <name>A0AAN6SNI6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_18322</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854460">
        <property type="protein sequence ID" value="KAK4034946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SNI6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF315">
        <property type="entry name" value="TRANSPORTER MCH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="318"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="352"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="387"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4034946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="425" mass="44587" checksum="1DA25099A5B66364" modified="2024-10-02" version="1">MENDAGVSELKDTTTKLPNGGYGWIIVVVAVAMNAVTWGMNMTIGVYVSFFVQDTYLSGGSPLRYSFIGGLSVGVALAAAPLGNLLIRHFGFRVPILLGTLCVTLGQCLAGISTRFAAYLVCQGLVFGFGLGIVFATSQPLLAQWFDKRLSLASGLAMGGAGAGGLILSNTTRVLVEKLSISQSLYINGGISAAVMLPCVFLVRKGPADIGIKSVSLQLQWLYHPAFVWVWIWGSLAVMGYFIALYSVASYATDGIGLSQTEAAAVQSLMASGLMIGRPLTGFALELGGRLNIALLANVIAGITCWALWLPARSFPLLAAFAFLHGCTAGSVWSAVLPVAAQVVGPSHLGPALAMFWLVAAAPAAVSSGLAHMLLDYSREALGKQGAEAYAISIVFCGGLYFVSGLSLYGAKVYSQQSFRVWTKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SNM9</accession>
    <name>A0AAN6SNM9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Acyl-CoA dehydrogenase/oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">C8A01DRAFT_19151</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854500">
        <property type="protein sequence ID" value="KAK4033987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SNM9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000002">
        <property type="entry name" value="Acyl-CoA dehydrogenase fadE12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050741">
        <property type="entry name" value="Acyl-CoA_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083:SF13">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0274">FAD</keyword>
    <keyword evidence="4 7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="10">
        <location>
            <begin position="15"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="9">
        <location>
            <begin position="144"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="8">
        <location>
            <begin position="258"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK4033987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="450" mass="49537" checksum="BF1102E31B663BE3" modified="2024-10-02" version="1">MSAQIPIAVRDRVSERAKKTLDVVAKFVDEDCIPADAVYEAQIGVGDARWNAHPPILEDLKKKARALGLWNMFLPKGHYKESPGFTNLEYGLMAEWLGKSRTASEAVNCAAPDTGNMEVLAKYGNDAQKAQWLKPLMEGEIRSAFLMTEPQVASSDARNIEMKIERDGDHYVLNGQKWWSSGAGDPRCKVYIVMGKSDANNKDPYSQQSVIIVPAEAQGITIHRMLSVYGYDDAPHGHGHITFKNVRVPASNLVLGEGRGFEIIQGRLGPGRIHHAMRTIGASERALEWMLMRINDPKKTTFGKQLREHGVILEWVAKSRIEIDAARLVVLNAAIKMDEQGPKAALKEIAQAKVLVPQTALTVIDRAVQSFGGAGVSQDTPLASMWAGIRTLRLADGPDEVHLQQMGRNENKRGKAVAEKIAGQKAKSEQLLKQYGAKHTELGSNIKRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SPI3</accession>
    <name>A0AAN6SPI3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_48840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854463">
        <property type="protein sequence ID" value="KAK4034843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SPI3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17615">
        <property type="entry name" value="C166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042845497" evidence="1">
        <location>
            <begin position="19"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4034843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="162" mass="16568" checksum="60AA5284A8CEE149" modified="2024-10-02" version="1">MRLSILAALAAFGSVAVAQLKATVVVENIQVLTTKSQALIQPAKELTIVNAPLLILGQGPWASSSASTTYVGAEATAIANAFRLFVKVHQQLLDALIGAGGVITKIPFVGPPVAAVLRSVEKVVDTLALGIIATVEASVAVTMKTDYAGLRVTLGTAVGTFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SPJ5</accession>
    <name>A0AAN6SPJ5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Isoaspartyl peptidase/L-asparaginase 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_17579</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Ntn-hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854432">
        <property type="protein sequence ID" value="KAK4038329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SPJ5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003948">
        <property type="term" value="F:N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04513">
        <property type="entry name" value="Glycosylasparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.30:FF:000003">
        <property type="entry name" value="N(4)-(Beta-N-acetylglucosaminyl)-L-asparaginase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.30">
        <property type="entry name" value="(Glycosyl)asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000246">
        <property type="entry name" value="Peptidase_T2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10188">
        <property type="entry name" value="L-ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10188:SF6">
        <property type="entry name" value="N(4)-(BETA-N-ACETYLGLUCOSAMINYL)-L-ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01112">
        <property type="entry name" value="Asparaginase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042861540" evidence="8">
        <location>
            <begin position="34"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="253"/>
            <end position="256"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="276"/>
            <end position="279"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="7">
        <location>
            <begin position="224"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4038329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="378" mass="39380" checksum="9757FA0E0F0E92B0" modified="2024-10-02" version="1">MTARRPHPARLTTLNLTHLSRLLLLALPTTTLATANPDLPFVINTWAGPFTAATDAAYHSLTNPSSPHSLTPALDAVEIGCATCEQNQCDTTVGFGGSPDEACETTLDALIMDGTTLNSGAVAGLRRIRDAVSVARAVLEHTRHSLLVGDLATRFAVQMGFGPEGDLGTVESRERCEAWRMGGCKGNYWVGVEPDPERGCGPYRPVGVPGGGLAGRDEGQMSHDTISMVVIDGDGVMAAGTSTNGAAFKIPGRVGDGPIVGSGSYVDGDVGGCGATGDGDIMMRFLPCYQAVENLRLGMTPTEAAEDAMRRMLRKYPKISSGVVVVNNKGEHGAAGSGWTFTYAFRGGTMNATEVVSIPPLTVVPAGGREAYDGPGEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SPU0</accession>
    <name>A0AAN6SPU0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar protein sorting/targeting protein 10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Carboxypeptidase Y receptor</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16 18">Sortilin VPS10</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19 20">Vacuolar carboxypeptidase Sorting receptor VPS10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">C8A01DRAFT_38377</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Functions as a sorting receptor in the Golgi compartment required for the intracellular sorting and delivery of soluble vacuolar proteins, like carboxypeptidase Y (CPY) and proteinase A. Executes multiple rounds of sorting by cycling between the late Golgi and a prevacuolar endosome-like compartment.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Prevacuolar compartment membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VPS10-related sortilin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854453">
        <property type="protein sequence ID" value="KAK4035173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15482">
        <property type="entry name" value="Sialidase_non-viral"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.270:FF:000005">
        <property type="entry name" value="Sortilin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.80">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031777">
        <property type="entry name" value="Sortilin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031778">
        <property type="entry name" value="Sortilin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006581">
        <property type="entry name" value="VPS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050310">
        <property type="entry name" value="VPS10-sortilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12106">
        <property type="entry name" value="SORTILIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12106:SF27">
        <property type="entry name" value="SORTILIN-RELATED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15902">
        <property type="entry name" value="Sortilin-Vps10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15901">
        <property type="entry name" value="Sortilin_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00602">
        <property type="entry name" value="VPS10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110296">
        <property type="entry name" value="Oligoxyloglucan reducing end-specific cellobiohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="Sialidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13 24" id="KW-0675">Receptor</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 22" id="KW-0732">Signal</keyword>
    <keyword evidence="6 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="22">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042937801" description="Vacuolar protein sorting/targeting protein 10" evidence="22">
        <location>
            <begin position="25"/>
            <end position="1507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="1372"/>
            <end position="1393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="1424"/>
            <end position="1445"/>
        </location>
    </feature>
    <feature type="domain" description="VPS10" evidence="23">
        <location>
            <begin position="51"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="domain" description="VPS10" evidence="23">
        <location>
            <begin position="729"/>
            <end position="1361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00025569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00031354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00031902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00032705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00032910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="SMART" id="SM00602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KAK4035173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1507" mass="168862" checksum="753559C26A22D6D5" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SPW3</accession>
    <name>A0AAN6SPW3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peroxisome assembly protein 12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Peroxin-12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">C8A01DRAFT_48123</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Component of the PEX2-PEX10-PEX12 retrotranslocation channel, composed of PEX2, PEX10 and PEX12.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the pex2/pex10/pex12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854435">
        <property type="protein sequence ID" value="KAK4038242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SPW3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990429">
        <property type="term" value="C:peroxisomal importomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016562">
        <property type="term" value="P:protein import into peroxisome matrix, receptor recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017375">
        <property type="entry name" value="PEX12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006845">
        <property type="entry name" value="Pex_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12888:SF0">
        <property type="entry name" value="PEROXISOME ASSEMBLY PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12888">
        <property type="entry name" value="PEROXISOME ASSEMBLY PROTEIN 12 PEROXIN-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04757">
        <property type="entry name" value="Pex2_Pex12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Pex N-terminal" evidence="17">
        <location>
            <begin position="25"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="288"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="298"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="309"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAK4038242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="422" mass="47336" checksum="ACC148A0F95757BC" modified="2024-10-02" version="1">MEFIPALHARLDEHKPSLFELLSEQQLASLLPPTLRYLLTILTHRYPRHLLRVLNSFDELYALAALLVERHYLRTRAGSFTEHFYGLKREKTLAAEIPRASAAAPGVVRDALRLSSADVWRNLAVIVGVPYLKRKLDEAYEVDAPRAMLGAAYNRAPGAGAGWRERVGFWWRWFLRRVYPRVNAAYYLAMLAFNLAYLFDNAKCHSPFLWLVGTRVRRMNAADYRAIEALEEKVAKAGATRSVGARMLGGLSLVLPTSIFALKFLEWWYASDFAKQLSRKAGESLDLPPPVVTGLPDGAKKAQAKEEKDAEEEELDDEEKERRAVEKAPIAASSLRPIYTVPAPEDSDQCPICEGEITTAAACQTGVVYCFACIHKWLTGTHARQEKFMAERAGKWESGEGRCAVTGRRVLGGTEGLRRIMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SQ58</accession>
    <name>A0AAN6SQ58_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_16965</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854413">
        <property type="protein sequence ID" value="KAK4038989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SQ58"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF252">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08550)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="157"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4038989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="336" mass="36402" checksum="C188CA6EFC8BF8C8" modified="2024-10-02" version="1">MPFFLPPVPALPPGIDRSGKTAIVTGATQGIGLEISRQLLTCKVSNLVLAVRNLPKGEAVRQALLSEPAVKTANPNATIQVLKLDAENYESVQHFVSVFKAEFHDLHLLFANAGIGTAAKELASSGHEKNIQVNYLSNVLLTLALLPTLETTATKTGEPTRVTWTGSRGHKQSSLAGKPSSKKGEQVLKHLDTADALPMFTRYADSKLLCVLFQLELARHYGPDKVIVNSFCPGMVDTGMTDVLPIYLRVPVNAVKAIRARSPKKAAWIALNAAVVAGAETHGRLLGDMAVEEPWEWIKSEEGQRVQKMVWNETIGEMAGMVDLPVWDINGDGMPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SQC9</accession>
    <name>A0AAN6SQC9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_37287</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854420">
        <property type="protein sequence ID" value="KAK4038722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SQC9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12398">
        <property type="entry name" value="RRM_CSTF2_RNA15_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000219">
        <property type="entry name" value="Putative polyadenylation factor subunit CstF64"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025742">
        <property type="entry name" value="CSTF2_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45735">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45735:SF2">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14327">
        <property type="entry name" value="CSTF2_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="8"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="85"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="109"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4038722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="248" mass="25870" checksum="B43B9855E99816D8" modified="2024-10-02" version="1" fragment="single">MSTRQPSRVVFVGNIPYGLTEEQITEIFSGAGRVLNFRLVYDRETGRPKGFGFAEFPDYDSAASAVRNLNDYEIMGRKLRVDFSNETVSDEDNRDRDGAPGASGSNYPNPAATNGGSSANAPSASIQPPTAAGSGSSSLPPLPQGKDLPPGVSCTDAISRTLNTLPPAQLLDILQQMKTLATADPSRATELLTQAPQLSYAIFQALLIMGLVSPDAINSVLEPGAPPIPAHQAQAAYGVAGAATGTPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SQR2</accession>
    <name>A0AAN6SQR2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Saccharopine dehydrogenase [NADP(+), L-glutamate-forming]</fullName>
            <ecNumber evidence="8">1.5.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Saccharopine reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">C8A01DRAFT_37285</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-saccharopine + NADP(+) + H2O = (S)-2-amino-6-oxohexanoate + L-glutamate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57951"/>
            <dbReference type="ChEBI" id="CHEBI:58321"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (fungal route): step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the saccharopine dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.10" evidence="8"/>
    <dbReference type="EMBL" id="MU854419">
        <property type="protein sequence ID" value="KAK4038795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SQR2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004755">
        <property type="term" value="F:saccharopine dehydrogenase (NADP+, L-glutamate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000008">
        <property type="entry name" value="Alpha-aminoadipic semialdehyde synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000072">
        <property type="entry name" value="Saccharopine dehydrogenase [NADP(+), L-glutamate-forming]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1870.10:FF:000002">
        <property type="entry name" value="Saccharopine dehydrogenase Lys9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1870.10">
        <property type="entry name" value="Domain 3, Saccharopine reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051168">
        <property type="entry name" value="AASS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032095">
        <property type="entry name" value="Sacchrp_dh-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133:SF22">
        <property type="entry name" value="ALPHA-AMINOADIPIC SEMIALDEHYDE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16653">
        <property type="entry name" value="Sacchrp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Saccharopine dehydrogenase NADP binding" evidence="11">
        <location>
            <begin position="7"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Saccharopine dehydrogenase-like C-terminal" evidence="12">
        <location>
            <begin position="125"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00051869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00060549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00066976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00067598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00083134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK4038795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="448" mass="48696" checksum="4AC0C602DAF81C1D" modified="2024-10-02" version="1">MASQHKVLMLGAGFVTRPTLDILSDAGIPVTVACRTLASAQQLSAGVANAHPISLDVNDDAALDAEVAKHDLVISLIPYTFHATVIKSAIRNKKNVVTTSYVSPAMLELDADAKAAGITVMNEIGLDPGIDHLYAIKTIDEVHKEGGKILSFLSYCGGLPAPEDSDNPLGYKFSWSSRGVLLALRNAGKWWQDGAAVEVAGKDLMKMAKPYFIYPGFAFVAYPNRDSTPYKERYAIPEAQTIVRGTLRYQGFPQFIKVLVDIGFLEDAPLDILSRPVAWKEATQAVVGAPSPSAADLEATILAKATFESDDDKQRILSGLRWIGLFGDEAITPKGNPLDTLCATLERKMQYEEGERDLVMLQHKFEIEHKDGSRETRTSTLCEYGDPKGYSAMAKLVGVPCAVAVKQVLSGQLRDKGILAPMTASICEPLMKELEEKYGITMVEKTIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SR96</accession>
    <name>A0AAN6SR96_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_36660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854402">
        <property type="protein sequence ID" value="KAK4039365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SR96"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="148"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4039365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="314" mass="32730" checksum="C2EB325D56357EF2" modified="2024-10-02" version="1">MSSPINSPRERPMSEIPTSPHPRGPFKTFGQEYQYAETLQNPFPEVIFAGPANAAHGTAPTSPVSAGGADGTNEPPTDHGTLSSHRPATTGSKEPVMHEDVWVEPAEAPWYTTISRRKWAAIIICTVGITGVMLAILGAMNKLSGTRSTPTTNPDPDSPTPSKTSADQTSSSDAPSSASSTPAAAATTLTTSTTSVRPTSTNHPSPKVDCTNPSTFLTPIFWIGTTVGAYNGAFAQAASAQACCTSCLNQPGCAGWLYDASSKYTPCTKVVVSRAMDDKGGGVETCPLGRAPTTYFSEGRDGEIDTSAMDHGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2025-10-08" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SRB3</accession>
    <name>A0AAN6SRB3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleolar pre-ribosomal-associated protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_36826</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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</entry>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
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                <person name="Calhoun S."/>
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                <person name="Kuo A."/>
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                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
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                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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    </evidence>
    <sequence length="337" mass="36744" checksum="3B0332E09CD1C727" modified="2024-10-02" version="1">MASKHRSEHPSRSPPTHYEAEEDDVTDNNGEGQSNADEVPGQTGAQQKDTPMRSKSPAYVAPIPRIGSIPQVSPGIPVSATDRPELPPSVGALLTGKLVDEDGDIVDEKTGQVLAHAAGDLPSMVGRRVSNAQGDILGDDGELLGYVADIEWPKGRPPPTAPPRSLFDLMGRATSSLMVDHTGNILDASGNIVGTFHDNNNPLHRKEKEEKEARERTQEKTKERSEQQQSLGDEDQHQRSPPPAPTPPPQQQEGQSQPQSQSQPQSQSQSTPGEGQTRPRRTEEEKQNAEAWRKENPNESPSDIFLDVKSTREGIQLTIRIPTVFNGQQTTPHISFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SSH6</accession>
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        <recommendedName>
            <fullName evidence="6">Secreted protein</fullName>
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    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854366">
        <property type="protein sequence ID" value="KAK4040957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SSH6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012878">
        <property type="entry name" value="Beta-AFase-like_GH127_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049046">
        <property type="entry name" value="Beta-AFase-like_GH127_middle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31151">
        <property type="entry name" value="PROLINE-TRNA LIGASE (DUF1680)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31151:SF0">
        <property type="entry name" value="PROLINE-TRNA LIGASE (DUF1680)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07944">
        <property type="entry name" value="Beta-AFase-like_GH127_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20736">
        <property type="entry name" value="Glyco_hydro127M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042959311" description="Secreted protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="domain" description="Non-reducing end beta-L-arabinofuranosidase-like GH127 catalytic" evidence="2">
        <location>
            <begin position="29"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="Non-reducing end beta-L-arabinofuranosidase-like GH127 middle" evidence="3">
        <location>
            <begin position="430"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4040957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="612" mass="66555" checksum="F511EA851033DDDB" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6ST92</accession>
    <name>A0AAN6ST92_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MFS transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_45409</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854357">
        <property type="protein sequence ID" value="KAK4041450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6ST92"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF164">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="311"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="394"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="426"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="462"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="496"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4041450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="529" mass="58216" checksum="13EBEC28F1237902" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6STQ5</accession>
    <name>A0AAN6STQ5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">60S ribosomal protein L22</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_34174</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854351">
        <property type="protein sequence ID" value="KAK4041796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6STQ5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.210:FF:000001">
        <property type="entry name" value="60S ribosomal protein L22 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002671">
        <property type="entry name" value="Ribosomal_eL22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038526">
        <property type="entry name" value="Ribosomal_eL22_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10064">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10064:SF31">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL22A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01776">
        <property type="entry name" value="Ribosomal_L22e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4041796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="126" mass="14265" checksum="B482D633CD79E17B" modified="2024-10-02" version="1">MAPIAKKTGAKKGPKVTRKFVINASQPASDKIFDVSAFEKFLNEKIKVEGRVGNLGETIKISQQGEGKIEIVAHNDLSGRYLKYLTKKFLKKMQLRDWLRVVSTSKGVYELKFFNVVNDEAEDDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6STX9</accession>
    <name>A0AAN6STX9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_33787</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854345">
        <property type="protein sequence ID" value="KAK4042155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6STX9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050085">
        <property type="term" value="F:mannitol 2-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019594">
        <property type="term" value="P:mannitol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000090">
        <property type="entry name" value="NADP-dependent mannitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF14">
        <property type="entry name" value="DEHYDROGENASE ARBD, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="51"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="59"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4042155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="388" mass="40978" checksum="09C4E4EF337E3C3E" modified="2024-10-02" version="1">MSFPVGRVLRSAAGRTRTARLLGTLPTPAASTIPSRFRAPVTAGAAGFHTVPAARRQDGSNNNRTSAQTTTENKPTDEELASAAGSFARTDDSITVEYPPEEQLPSSEPVAGTDRAGAHVFPTLATFSLQGKVGVVTGGARGLGLVMGQGMVISGADLAIVDLNKEEATRQAQNIVDTFRNDHPDKKPPKVTAHYADVSDPASVEACIAEIVAEHGRIDNLVTSAGFTENFEAVAYPIDRMRKLWGVNVDGTYLFATSVARHLMGRNAKGSMVFIGSMSGAIVNVPQPQAPYNAAKAAVRHLASSLSVEWAGAGIRVNCISPGYMLTALTQKILDDKPDLKRQWTSLIPQGRMGAPEDLMGPVTFLLSDASSYVTGADLRVDGGYTVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SU37</accession>
    <name>A0AAN6SU37_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF7728 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_33818</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854345">
        <property type="protein sequence ID" value="KAK4042186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SU37"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056145">
        <property type="entry name" value="DUF7728"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40622">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40622:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24854">
        <property type="entry name" value="DUF7728"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042994768" description="DUF7728 domain-containing protein" evidence="3">
        <location>
            <begin position="21"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="305"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7728" evidence="4">
        <location>
            <begin position="47"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4042186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="391" mass="43605" checksum="127390003E9DF654" modified="2024-10-02" version="1">MLLKPLTLAAGLLAVPATQAFLVPPEVSDADVQVANTIESIGAQVAQTQVIDVECPGCPILLTGRRGKHIQVYIDRPSHLELTFSVDHQPDHDRLLVNGLPIYPSDDLMRTTLLSAPQIVDREDKEKRHRPEHDHHDREHRRRPHKVTPQPQKLGFGLHVGTSQKDADGQFELVELELQIIAVGVAFIDGIPNVKVKLVKDAEGRLLMSQIEKGEPKQMLHHPGSGAEECTTVMCQWLAFARAKLEKLKNLKGFKNCHGGKGGMKPPVSGEAPHHHPHHPAPDNWRAPYHEHRWGKLLKHMASHILLPVLIGIVAGVSVSLVGMAVGTVIVSLWRVLFRRRRHSHHSHHHKAARKEAVFEEEKSGLMAYQDAPPSYEEQEEEEEVVKAAQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SUA3</accession>
    <name>A0AAN6SUA3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_44631</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854342">
        <property type="protein sequence ID" value="KAK4042381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SUA3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052099">
        <property type="entry name" value="Regulatory_TF_Diverse"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47336">
        <property type="entry name" value="TRANSCRIPTION FACTOR HMS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47336:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR HMS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="3">
        <location>
            <begin position="341"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="59"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="141"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="293"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="398"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="59"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4042381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="457" mass="49816" checksum="17129339F541477C" modified="2024-10-02" version="1">MDSDPLGHLEFFSMPNNQTINPVDQPFLAGTSTQPPSIWSPAGLRLDTGLTMSPSVAPTTLSLDSVPQPSPLTGLTTMSPGLSSTSRPPAQGIQSRPVLPARGPRTKDRHERKRSRLSIDASTPLDSVDYWIDFDNDDNLPSIPEALEPQRPNIDKKGKAPMRRPPKPAPPPPTAKSDDWLDDSALDNALSDEDDFSSINLADHLSKIDAAPPQEVPPREGLYSTPLSWERPQLGIRSDSLAGLHSPSLNEAEQRRLIAIAMNPGPSMGGLGSNINFNFGGMAPGMPMAFGAGLGSASTSQGPTPVSPPHPSGAQHRPGPPNPPKKQGSVSEKDKEKAKAGERTAHNDIERKYRTNLKDKISELRDAVPALRTISENDIEDEETQPSRTANVSKGTVLTKATEYIHLLERRNKQIEQEHRELSRRLQAFEQLLNATARQAYTMPTYSRTLFDPRGFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SUA6</accession>
    <name>A0AAN6SUA6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_13555</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854335">
        <property type="protein sequence ID" value="KAK4042817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SUA6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16616">
        <property type="entry name" value="mRING-HC-C4C4_Asi1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22696">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22696:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="331"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="359"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="398"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="589"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="622"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="717"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="894"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="740"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="751"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="780"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="894"/>
            <end position="912"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4042817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="996" mass="108387" checksum="DEDD9250BD4DC24D" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SV35</accession>
    <name>A0AAN6SV35_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_32696</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854330">
        <property type="protein sequence ID" value="KAK4043206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SV35"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="98"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4043206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="226" mass="24542" checksum="B3CB04E8B175CA1E" modified="2024-10-02" version="1">MPFTWESVYSFFSPPATRTSSPEGTPSLLSAAFSSKFNVPTTTKQTDLPMPPTTALGAAAAGPPMPSPAESSTSSLAASERDYFPPNSAYNSSRRRPSMSSTSTASTAASELQLPHQPQRSHTTPAPASQDERPPAPRRSATEVVAPEPMSRQFPKPTHEPSLDELLARKPGKFSLSHYVKNPREQKIPGELATEAEAAERARKFAEVKRKLVMDHEKIASLVEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SV41</accession>
    <name>A0AAN6SV41_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 10">Lysophospholipase</fullName>
            <ecNumber evidence="2 10">3.1.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">C8A01DRAFT_32246</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15177"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the lysophospholipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.5" evidence="2 10"/>
    <dbReference type="EMBL" id="MU854325">
        <property type="protein sequence ID" value="KAK4043717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SV41"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1090.10:FF:000010">
        <property type="entry name" value="Lysophospholipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002642">
        <property type="entry name" value="LysoPLipase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728">
        <property type="entry name" value="CYTOSOLIC PHOSPHOLIPASE A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728:SF33">
        <property type="entry name" value="LYSOPHOSPHOLIPASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01735">
        <property type="entry name" value="PLA2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00022">
        <property type="entry name" value="PLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51210">
        <property type="entry name" value="PLA2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 9 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9 10" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6 9 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042671698" description="Lysophospholipase" evidence="10">
        <location>
            <begin position="19"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="domain" description="PLA2c" evidence="12">
        <location>
            <begin position="51"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="26"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK4043717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="657" mass="69467" checksum="66AB10EE4A0389BC" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SVB5</accession>
    <name>A0AAN6SVB5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_32387</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854327">
        <property type="protein sequence ID" value="KAK4043461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SVB5"/>
    <dbReference type="Proteomes" id="UP001303115">
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4043461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="74" mass="7949" checksum="918EBA5321609CF9" modified="2024-10-02" version="1">MSTTQGAYSVSMPLSPPPPPDLGTYARSMHQHTKRQMESISPQSPPRSSQHSQPAPTGLPDGVVGRSRNSSQYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAN6SVK2_9PEZI</name>
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        <recommendedName>
            <fullName evidence="2">EH domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">C8A01DRAFT_31189</name>
    </gene>
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        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854317">
        <property type="protein sequence ID" value="KAK4044689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SVK2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00052">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000261">
        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12763">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00027">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50031">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EH" evidence="2">
        <location>
            <begin position="759"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="594"/>
            <end position="704"/>
        </location>
    </feature>
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        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="118"/>
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            <begin position="281"/>
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            <begin position="318"/>
            <end position="330"/>
        </location>
    </feature>
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        <location>
            <begin position="357"/>
            <end position="367"/>
        </location>
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        <location>
            <begin position="374"/>
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        <location>
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            <end position="422"/>
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        <location>
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            <end position="529"/>
        </location>
    </feature>
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        </location>
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            <begin position="640"/>
            <end position="652"/>
        </location>
    </feature>
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            <end position="668"/>
        </location>
    </feature>
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        <location>
            <begin position="676"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4044689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="864" mass="90059" checksum="8C8F05A3340E0D79" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SVQ3</accession>
    <name>A0AAN6SVQ3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">C8A01DRAFT_43378</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854324">
        <property type="protein sequence ID" value="KAK4043823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SVQ3"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37542">
        <property type="entry name" value="HELO DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37542:SF1">
        <property type="entry name" value="PRION-INHIBITION AND PROPAGATION HELO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="157"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4043823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="543" mass="60641" checksum="5B4F3B633898170B" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SW05</accession>
    <name>A0AAN6SW05_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_43095</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
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        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854321">
        <property type="protein sequence ID" value="KAK4044181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SW05"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF115">
        <property type="entry name" value="DEHYDROGENASE XPTC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043056220" description="Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein" evidence="4">
        <location>
            <begin position="18"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="5">
        <location>
            <begin position="341"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="603"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="647"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="43"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4044181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="672" mass="72233" checksum="9B81055E2FAE542F" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SWP9</accession>
    <name>A0AAN6SWP9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Isoamyl alcohol oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_31059</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854316">
        <property type="protein sequence ID" value="KAK4044873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SWP9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050432">
        <property type="entry name" value="FAD-linked_Oxidoreductases_BP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878:SF91">
        <property type="entry name" value="FAD BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G12070)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878">
        <property type="entry name" value="GULONOLACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042845307" evidence="3">
        <location>
            <begin position="24"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="4">
        <location>
            <begin position="117"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4044873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="571" mass="61385" checksum="F07A7C0ED4342E31" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P480</accession>
    <name>A0AAN6P480_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_21366</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854824">
        <property type="protein sequence ID" value="KAK4031404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P480"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021833">
        <property type="entry name" value="DUF3425"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37012">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37012:SF2">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11905">
        <property type="entry name" value="DUF3425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4031404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="361" mass="41416" checksum="D83C6EEFA24D46A7" modified="2024-10-02" version="1">MSALSPPPAKRKRVRTASQLEQKRFTDRIKQRENRHENKNRLDKIEGDIADIKSTLQALAVHLQSQVPIPALPDPSITWPSRQEPVPLRPRHREFYDSSASAAPHLLLGAHLGPGDQVFEPQAWASWPRSSWSPTSSGNNRLWTSIPCIESKLINCHCGSQHLDRFDCLDQCSVTTFYQLQIAFPTTRSTSGILPRNPSLPSMMLHTMDENIATFLITGFLRQYKNKGIEQLLSFYLLGYRYMRWKMSPCEETIRDVPAWMLPTEIQKSNPHSVIVDYVPWPRLRDHLCTSGDEDLARSLYFYFESTEFIWPSECPIFAQGEGGQMTPSLEFERAVGNLEHWRIGPPWSEAFPHLLHLVEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P487</accession>
    <name>A0AAN6P487_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EthD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_42236</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tpcK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854891">
        <property type="protein sequence ID" value="KAK4031300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P487"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009799">
        <property type="entry name" value="EthD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07110">
        <property type="entry name" value="EthD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EthD" evidence="2">
        <location>
            <begin position="13"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4031300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="117" mass="13536" checksum="8D4B27AE79CFA81B" modified="2024-10-02" version="1">MVVRVYLLAVKAPGISFEEFKKQWDVDHINLLREMAGDAYPQVWYHRYPTQAVARGPADATTKFDGIGYLEFKDKAAFLKLRDLTRGTPENAARLEAHERSFLDVDKLQMYIVEDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P4A9</accession>
    <name>A0AAN6P4A9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heterokaryon incompatibility protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_42068</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854790">
        <property type="protein sequence ID" value="KAK4031486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P4A9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF82">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26639">
        <property type="entry name" value="Het-6_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="19"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4031486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="502" mass="55721" checksum="CB5096ABC612ADAD" modified="2024-10-02" version="1">MNPIQCKLRHASLQDDLDYAAVSYVWAEVPGIEVIDVDGHTVGIGKNLWVLLNQFRGETPLVLWVDAICINQKDDQEKSEQVAKMESIYKRASEVKIWLGLSKDARDAVMDIFNEFSTLHDIVSRIQTLHLYPSRAALPEPITIVLEGLIERFRDRPETTATPLLKFFFERQWWARVCIIQEFVLARNATFYCGDRSVTNLGFVKALTILRYMREAHLTKTMILYQHCSDNNEPITLADIYTLAKADNQIKATNPRDLVYGLLGLVSSEDRAGTPVDYTLSAGEVFALATAAIMRAYGVDSGTTITIPGVFVDTILHAGSHRGFHPEGDLDPSPTNVQDWLDEAISLIPTTPAPSRVPVPTAIDNLWQIPILDHIHSRFSDSQTRATPSDKHGYDVLLGLVTPPDDITNLAAWRLQQSETYRDNIGIGARRSFATTMGFLGLAPEGVCAGDRVCLLAGATTPFVLREAVAGMYYLVGECYVQGIMDGEWTGGEGEVVEFELC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P4S1</accession>
    <name>A0AAN6P4S1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">C8A01DRAFT_41810</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">ATP-dependent RNA helicase associated with the nuclear pore complex and essential for mRNA export from the nucleus. May participate in a terminal step of mRNA export through the removal of proteins that accompany mRNA through the nucleopore complex. May also be involved in early transcription.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">Associates with the nuclear pore complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the DEAD box helicase family. DDX19/DBP5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="EMBL" id="MU854711">
        <property type="protein sequence ID" value="KAK4031743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P4S1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17963">
        <property type="entry name" value="DEADc_DDX19_DDX25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000849">
        <property type="entry name" value="ATP-dependent RNA helicase DBP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 17" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 17 22" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="11" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="4 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0811">Translocation</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="21">
        <location>
            <begin position="79"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="19">
        <location>
            <begin position="112"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="20">
        <location>
            <begin position="292"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="16">
        <location>
            <begin position="79"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAK4031743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="486" mass="53131" checksum="E8AE3DD873AD5444" modified="2024-10-02" version="1">MADLASRISKPSDAPVDDKAPAAPDAPAAAEGNGAEGNGAEQPVDDGVQRGLIETTYDVEVKLSDLQADQESPLYSGVSSFEELGLPKSINDGLLAMNFKKPSKIQERALPLMISDPPTNMIAQSQSGTGKTAAFVLTVLSRVDLAKPTQPQALLLAPSRELARQIQGVIQTIGQFCENLVVEAAIPGSISRETGVRASVVVGTPGTVMDLIRRRQFDVSQLKVLVIDEADNMLDQQGMGDQCLRVKGMLPKTIQILLFSATFPDKVMNFARKYAANANEIKLRHQELTVKGISQMYMDCPDETKKYDVLCKLYGLMTIGSSVIFVKTRESASEIQRRMEADGHKVSALHGAYEGQNRDALLDDFRSGRSKVLITTNVLARGIDVSSVSMVINYDIPMKGFGDREPDMETYLHRIGRTGRFGRVGVSISFVYDQKSFNALSQIANHYDIDLVQLSPDDWDMTEKKVQEVIKSSRARPDYAPNALGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P6C2</accession>
    <name>A0AAN6P6C2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">FACT complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">C8A01DRAFT_41067</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the FACT complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the peptidase M24 family. SPT16 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854605">
        <property type="protein sequence ID" value="KAK4032484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P6C2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035101">
        <property type="term" value="C:FACT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034728">
        <property type="term" value="P:nucleosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01091">
        <property type="entry name" value="CDC68-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.150:FF:000002">
        <property type="entry name" value="FACT complex subunit SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.210:FF:000001">
        <property type="entry name" value="FACT complex subunit spt16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000017">
        <property type="entry name" value="FACT complex subunit SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.350.10:FF:000006">
        <property type="entry name" value="FACT complex subunit SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000005">
        <property type="entry name" value="FACT complex subunit spt16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.210">
        <property type="entry name" value="FACT complex subunit Spt16p/Cdc68p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029148">
        <property type="entry name" value="FACT-SPT16_Nlobe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056595">
        <property type="entry name" value="Fact-SPT16_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048969">
        <property type="entry name" value="FACT_SPT16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013953">
        <property type="entry name" value="FACT_SPT16_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013719">
        <property type="entry name" value="RTT106/SPT16-like_middle_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040258">
        <property type="entry name" value="Spt16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033825">
        <property type="entry name" value="Spt16_M24"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13980">
        <property type="entry name" value="CDC68 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13980:SF15">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14826">
        <property type="entry name" value="FACT-Spt16_Nlob"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24824">
        <property type="entry name" value="PH_SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08512">
        <property type="entry name" value="Rttp106-like_middle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08644">
        <property type="entry name" value="SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21091">
        <property type="entry name" value="SPT16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01285">
        <property type="entry name" value="FACT-Spt16_Nlob"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01287">
        <property type="entry name" value="Rtt106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01286">
        <property type="entry name" value="SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="FACT complex subunit SPT16 N-terminal lobe" evidence="14">
        <location>
            <begin position="6"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="FACT complex subunit SPT16 middle" evidence="15">
        <location>
            <begin position="547"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="domain" description="Histone chaperone RTT106/FACT complex subunit SPT16-like middle" evidence="16">
        <location>
            <begin position="821"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="445"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="942"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="626"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="476"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="503"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="943"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="987"/>
            <end position="1005"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAK4032484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1033" mass="117731" checksum="9C250CDB1E8306B7" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P6P2</accession>
    <name>A0AAN6P6P2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">C8A01DRAFT_41748</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ZNF598/HEL2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="MU854698">
        <property type="protein sequence ID" value="KAK4031807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P6P2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16615">
        <property type="entry name" value="RING-HC_ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057634">
        <property type="entry name" value="PAH_ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041888">
        <property type="entry name" value="RING-HC_ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056437">
        <property type="entry name" value="Znf-C2H2_ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044288">
        <property type="entry name" value="ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22938:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22938">
        <property type="entry name" value="ZINC FINGER PROTEIN 598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23202">
        <property type="entry name" value="PAH_ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23230">
        <property type="entry name" value="zf-C2H2_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="100"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="370"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="420"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="614"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="748"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="29"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="370"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="634"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="671"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="691"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="750"/>
            <end position="791"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00035113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK4031807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="805" mass="85757" checksum="C4E0D8FD7DBF8615" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P6S2</accession>
    <name>A0AAN6P6S2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Erythromycin esterase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_40766</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854575">
        <property type="protein sequence ID" value="KAK4032791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P6S2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14728">
        <property type="entry name" value="Ere-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1660.10">
        <property type="entry name" value="EreA-like (biosynthetic domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1870.10">
        <property type="entry name" value="EreA-like, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007815">
        <property type="entry name" value="Emycin_Estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052036">
        <property type="entry name" value="Hydrolase/PRTase-associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014622">
        <property type="entry name" value="UCP036794_erythomycin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31299">
        <property type="entry name" value="ESTERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31299:SF0">
        <property type="entry name" value="ESTERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05139">
        <property type="entry name" value="Erythro_esteras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036794">
        <property type="entry name" value="UCP_erythr_ester"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159501">
        <property type="entry name" value="EreA/ChaN-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4032791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="476" mass="53810" checksum="F17AEC3B42F869F5" modified="2024-10-02" version="1">MTSIDQDPALPLLRANLTPIPPLTESTTALTTFISRFCTTTSSNDNPEGETPKIILIGDASHGTSEFYAARAELTKHLIQHHNFNIVAVEADWPDAEAVDRYVRHRPGPGARASIGPEGETRKAGREPAFMRFPTWMWRNQEVQRFTEWLRAYNKGREPQAADAVGFYGLDLYSLGASMKAVVGYLEHVDGEMAEVARERYSRMMVWAEDPHEYGLEALASGFSGCEKDVVRVLRDLLGKRLEYAARSADGEEFHSGEQNARLVKDAEQYYKAMYYGRDESWNLRDRHMFDTLVRVLKHRGKNGPAKAVVWAHNSHIGDARATNMGWSREELNIGQLCKETFGKQAVNIGCCGNTGTVAAARRWDGDMQVMQVRPGLQNSYEELMHATGVKSFVLDLREGHCDEELRQALMKKRLERFIGVIYAPHTERQSHYSSAVLPEQLDGLVWFDETRHVGALEVHQPHVALEYDETWPFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P6T3</accession>
    <name>A0AAN6P6T3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_40828</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854580">
        <property type="protein sequence ID" value="KAK4032739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P6T3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF31">
        <property type="entry name" value="LAEA-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G01930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="11"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4032739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="359" mass="39675" checksum="35DF7961D3EE596D" modified="2024-10-02" version="1">MGDSTPKSGTSPGRPSKSASPPAASASPGPADPLGNVGALEAEEHDNDADSLLSVEAESDTTSVTSSIYRFREENGRTYHAYRASEAAYFLPNDESENERLDLQHNLFLLSQDNRLFLSPAGKDKPLHRVLDAGTGTGIWAIEFADENPDVAVVGTDLSPIQPAFVPPNLEFFVDDLENDWTFVTKFDFIYARMLTGAIKDWPRLCSQAYQHLNPGAYIELADVLPLTCDDGTFPDDCPLAQWNRHLVDGSAKHGASMRSAELYKQQLLDVGFQDVVQVEYKWPINTWAKDSKHKEIGAWSSENILSGIQGISLMLFTNILGWSAAEVETFLVGVRKDLRNKSIHAYWPVIVVYGRKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P6W0</accession>
    <name>A0AAN6P6W0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GMC oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_51444</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854786">
        <property type="protein sequence ID" value="KAK4031493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P6W0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF80">
        <property type="entry name" value="GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042904891" evidence="3">
        <location>
            <begin position="20"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="4">
        <location>
            <begin position="354"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4031493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="659" mass="71324" checksum="C64E460A981104D7" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P7B4</accession>
    <name>A0AAN6P7B4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_50326</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854558">
        <property type="protein sequence ID" value="KAK4033009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P7B4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018825">
        <property type="entry name" value="DUF2427"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018827">
        <property type="entry name" value="YTP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31685:SF3">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_6G12730)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31685">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_6G12730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10348">
        <property type="entry name" value="DUF2427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10355">
        <property type="entry name" value="Ytp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042943987" description="Integral membrane protein" evidence="3">
        <location>
            <begin position="27"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="333"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="475"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="514"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="543"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="578"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2427" evidence="4">
        <location>
            <begin position="58"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="Protein YTP1-like C-terminal" evidence="5">
        <location>
            <begin position="301"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4033009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="613" mass="66670" checksum="1FA972674FBC6CAD" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P7N0</accession>
    <name>A0AAN6P7N0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_50142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854544">
        <property type="protein sequence ID" value="KAK4033219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P7N0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="562"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="647"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="419"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="462"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="514"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="534"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="569"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4033219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="686" mass="70053" checksum="3A4A3FFFF0AC5E08" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P7R5</accession>
    <name>A0AAN6P7R5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_21466</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854896">
        <property type="protein sequence ID" value="KAK4031296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P7R5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4031296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="83" mass="9418" checksum="A6C01C6E24966384" modified="2024-10-02" version="1" fragment="single">TLYPRVRDLAQRHHDSFIRTANTRARQTDAEAPPELEITVAVAEQDEESTNEFVDCEDYPGLQAIGIEDYAISRDIDEELALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P802</accession>
    <name>A0AAN6P802_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Come operon protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_19682</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854535">
        <property type="protein sequence ID" value="KAK4033355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P802"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140673">
        <property type="term" value="P:transcription elongation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051265">
        <property type="entry name" value="HIBADH-related_NP60_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048666">
        <property type="entry name" value="RedAm-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43580:SF2">
        <property type="entry name" value="CYTOKINE-LIKE NUCLEAR FACTOR N-PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43580">
        <property type="entry name" value="OXIDOREDUCTASE GLYR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21761">
        <property type="entry name" value="RedAm-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="2">
        <location>
            <begin position="4"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="NADPH-dependent reductive aminase-like C-terminal" evidence="3">
        <location>
            <begin position="171"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4033355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="309" mass="32116" checksum="D1CFBA31390D5FF9" modified="2024-10-02" version="1">MTTVTSIGIGNMGAALAATLLASPNPPALTIWNRTADRPLVKSLITQGAHFEPSLAAAIARSTTLLICLLDYPSLTSALTTLSSTTPNPLAGKTIINVTNGTPNQARAMESHLKSLGAAAYFDGGIMVTPQLVGTPASFVILSGETEALFHSSIAGLLKPIGAVQYVSPEVGAASLYDVAALTAMYGMFMGAFTGIALLKKQRLRQVGGEDGEKVLAKPATDAVMMPVLKALVPYVSLLAECVDKEDWMNDLGNPLAMQAAAGKNILQTCEEEGVDGAGVRFISQLMDRGVEEGFGAGGLATVAKYLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P8G8</accession>
    <name>A0AAN6P8G8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UEV domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_51316</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854724">
        <property type="protein sequence ID" value="KAK4031701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P8G8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11685">
        <property type="entry name" value="UEV_TSG101-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052070">
        <property type="entry name" value="ESCRT-I_UEV_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008883">
        <property type="entry name" value="UEV_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23306:SF3">
        <property type="entry name" value="TUMOR SUPPRESSOR PROTEIN 101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23306">
        <property type="entry name" value="TUMOR SUSCEPTIBILITY GENE 101 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05743">
        <property type="entry name" value="UEV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51322">
        <property type="entry name" value="UEV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UEV" evidence="1">
        <location>
            <begin position="6"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4031701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="129" mass="14680" checksum="68EFCBD29C2FE8E8" modified="2024-10-02" version="1">MVVQQHVLNWLYSVLTSEYHDVNRTYNDVAQALSQHPSLSPRTDVHTFPNGTSALLVHLTGTIPVLFRGATYRFPVSIWVPHAYPREPPLAYVTPTETMVVRPGQHVDPQGQVYHPYLVGWSTFWDVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P8Y6</accession>
    <name>A0AAN6P8Y6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_41903</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAK4031652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP001303115">
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4031652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="216" mass="22492" checksum="1CA1D0100CF8E522" modified="2024-10-02" version="1">MHAIWTAGWATVAIFSGTTTALGAQYPFLSSDLEKASSALTVVPLHGRAGKGLLPPHMENGAILSLGPTFMNAIYENSTDTDLGSCWGCAVTIAKELPCIYEAIKTVSVSALLNCGVDKSDLCNCADCLPDAVEQYVEQFCSAKGKPKKPTLKNPTAAAERIADQDINFQGFKGSLPKATMNDLKAVNFCPGSSCGSCDCCIGVCFVGECMGGCGG</sequence>
</entry>
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        <recommendedName>
            <fullName evidence="5">Ubiquitin interaction domain-containing protein</fullName>
        </recommendedName>
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        <name evidence="3" type="ORF">C8A01DRAFT_49516</name>
    </gene>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854500">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055335">
        <property type="entry name" value="Ucp6/RUP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39597">
        <property type="entry name" value="UBA DOMAIN-CONTAINING PROTEIN RUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39597:SF1">
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="153"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="565"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="655"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="813"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="483"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
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            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
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            <begin position="171"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="674"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="724"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="816"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="826"/>
            <end position="836"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4033976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="862" mass="95094" checksum="DD6DE108FFB79E7A" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P9I3</accession>
    <name>A0AAN6P9I3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">C8A01DRAFT_39255</name>
    </gene>
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    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854487">
        <property type="protein sequence ID" value="KAK4034246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P9I3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="1"/>
            <end position="24"/>
        </location>
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    <feature type="compositionally biased region" description="Gly residues" evidence="1">
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            <begin position="1"/>
            <end position="16"/>
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    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4034246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="70" mass="7005" checksum="5366CE35A1DC97FD" modified="2024-10-02" version="1" fragment="single">GRKTAGGGGGGGGGASRGKKKVSMGVALHDGDAAEKKVEDEAGPVENAWWLGDGAIEELKGRTWLAGREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P9Y4</accession>
    <name>A0AAN6P9Y4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_19554</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
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            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854525">
        <property type="protein sequence ID" value="KAK4033515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P9Y4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4033515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="104" mass="10884" checksum="AFD5D1B7405A0BE8" modified="2024-10-02" version="1" fragment="single">VCLDNQIFYNPAVTAGLSGLLVRKGNPSAAILGAPSHPPPPPPPPPPPPPPPPPPPPLQDTYDPQPPSAGKSQDDTILILSDGEPDNNLDDSRSDVSFLPFEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PA54</accession>
    <name>A0AAN6PA54_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_20637</name>
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    <organism evidence="7 8">
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            <taxon>Pezizomycotina</taxon>
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        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854629">
        <property type="protein sequence ID" value="KAK4032267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PA54"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF33">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="37"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="519"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="537"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4032267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="620" mass="68087" checksum="B2143FEEAFCC3E68" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PAD3</accession>
    <name>A0AAN6PAD3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Pectinesterase</fullName>
            <ecNumber evidence="4 11">3.1.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">C8A01DRAFT_20264</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in maceration and soft-rotting of plant tissue.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>[(1-&gt;4)-alpha-D-galacturonosyl methyl ester](n) + n H2O = [(1-&gt;4)-alpha-D-galacturonosyl](n) + n methanol + n H(+)</text>
            <dbReference type="Rhea" id="RHEA:22380"/>
            <dbReference type="Rhea" id="RHEA-COMP:14570"/>
            <dbReference type="Rhea" id="RHEA-COMP:14573"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17790"/>
            <dbReference type="ChEBI" id="CHEBI:140522"/>
            <dbReference type="ChEBI" id="CHEBI:140523"/>
            <dbReference type="EC" id="3.1.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Glycan metabolism; pectin degradation; 2-dehydro-3-deoxy-D-gluconate from pectin: step 1/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the pectinesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.11" evidence="4 11"/>
    <dbReference type="EMBL" id="MU854583">
        <property type="protein sequence ID" value="KAK4032691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PAD3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030599">
        <property type="term" value="F:pectinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042545">
        <property type="term" value="P:cell wall modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000014">
        <property type="entry name" value="Pectinesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033131">
        <property type="entry name" value="Pectinesterase_Asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000070">
        <property type="entry name" value="Pectinesterase_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31321">
        <property type="entry name" value="ACYL-COA THIOESTER HYDROLASE YBHC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31321:SF127">
        <property type="entry name" value="PECTINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01095">
        <property type="entry name" value="Pectinesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00503">
        <property type="entry name" value="PECTINESTERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0063">Aspartyl esterase</keyword>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042669765" description="Pectinesterase" evidence="11">
        <location>
            <begin position="18"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Pectinesterase catalytic" evidence="12">
        <location>
            <begin position="39"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK4032691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="336" mass="35589" checksum="27CA6C1C8057D6FA" modified="2024-10-02" version="1">MLPSLALVLSLTTAAAAAPSCLEARAARTSPPAGCLAVGSSATYKTVQSAVNALSTSSTSAQCIFIYKGTYKEQVYIPQLSSALAIYGETTDTASFSSNTVTITQGKSQDDSPNNDETATLRAHTTNLKVYNINLVNTRGQGSQALAVSAQKDKQGYYACQFKGFQDTILANDGAQVYAKSYIEGATDFIFGQKARAWFDGADIRVLAASVGYVTANGRDSASNPSYYVINKSTVSAKAGDTVKAGAYYLGRPWRAFARVVFQQTTMSNVINAAGWKIWNTGDERIDGVEFGEYGNSGDGAKGTRASFSKKLSAAVGISTVLGSDYKSWVDTTYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PAL6</accession>
    <name>A0AAN6PAL6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_38694</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854464">
        <property type="protein sequence ID" value="KAK4034819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PAL6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4034819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="224" mass="24860" checksum="419D13E7AD0FB462" modified="2024-10-02" version="1">MLLLYPDQPNHHWEEDELPLRERASNGSFRVPALDVFFAFLEHGEKTYGFAYTCIGGTSIPVDLAQAARAAIAVDPWDALFTTAGLLFAPFHEFINLRGGNNGPVRDVDTEIGPQIVMSFTHSWAASLPEFLPLDHLLVGTYESALSLGVLLPERPTTLELVHDALSRAVDRARADNCFEQWLSPGLFLVLESKDGSVKENCDYDGFGDVEAVQYMRDHDGHDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PBA0</accession>
    <name>A0AAN6PBA0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">C8A01DRAFT_48565</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854452">
        <property type="protein sequence ID" value="KAK4035178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PBA0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF143">
        <property type="entry name" value="EXTRACELLULAR MEMBRANE PROTEIN CFEM DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="14" id="KW-0349">Heme</keyword>
    <keyword evidence="14" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 16" id="KW-0732">Signal</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042940809" description="CFEM domain-containing protein" evidence="16">
        <location>
            <begin position="22"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="163"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="187"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="271"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="17">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="14">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="27"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="31"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="50"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAK4035178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="402" mass="43846" checksum="B2D5A5DCEE68886A" modified="2024-10-02" version="1">MRSTVWAAALAIASLAVRASAQEMPTCASDCLVKYLPESKCESTDLDCICADQILTANVGTCTLGACTLFEALAAKNATATLCKEPIRDRSLVAPIATAITGGMALAFVLLRLYGSAVRRKEFHWADVWAVLTMVSSIPMDVGEFFMMAHGMGKDIWTLTPEAITNVVKITVLCFFMHVFPAQGFQLVCWGTIIHCVLFMVSTTIAAILTCVPVQSAWSAWTGTAEGVCCDNNTFWWAHSAINIATDLWILALPIPQLLKLQLGRKKKIYLVMMFSVGLVITIFNIVGFSGLVTYSTSSNPTCNHYSVVECNISIMCCCMPSLLSFLRHVLPTVFGSTNRSNNYKAGSYHGGGGGRSPFPSNAIQKSVTHTVSYLPRPGDSGVVELMDVEKNKQEEEQYNRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PBF2</accession>
    <name>A0AAN6PBF2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="8">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_17988</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="8"/>
    <dbReference type="EMBL" id="MU854448">
        <property type="protein sequence ID" value="KAK4035311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PBF2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF89">
        <property type="entry name" value="ALPHA-1,2-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 8 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="531"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="355"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4035311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="543" mass="61382" checksum="21026A7EC8822050" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PBW0</accession>
    <name>A0AAN6PBW0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_38316</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854451">
        <property type="protein sequence ID" value="KAK4035224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PBW0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630">
        <property type="entry name" value="DIENELACTONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630:SF55">
        <property type="entry name" value="DIENELACTONE HYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G01900)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="30"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4035224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="258" mass="28154" checksum="5796D8589F94600A" modified="2024-10-02" version="1">MSTCCLRSTLWEGTPTGTVTTLAGAPNPVYVANPAPTSTSRAAILLIHDLLGWTFPNARLLADAYAREADATVYLPDFFGGEVVPFEPVLAGRFDEIDLPAWTARNNREVREPEIVAFARALRASGEYDKIGAIGFCFGGWAVFRLGAHEFAQEGGGKGLVDCISAGHPTWLTEKDVEEVAVPAQLLAPELDITFTAEMKLFTFSALQKKGISFDYQHLPGVMHGCLTRGDATHKGEREAMVRGKDAAVAWFRQWLHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PC58</accession>
    <name>A0AAN6PC58_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">C8A01DRAFT_49006</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854470">
        <property type="protein sequence ID" value="KAK4034672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PC58"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF17">
        <property type="entry name" value="HELICASE-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="314"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="367"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="590"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK4034672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="609" mass="69017" checksum="1243AFC8D56038DC" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PC89</accession>
    <name>A0AAN6PC89_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Tubulin binding cofactor C-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_37746</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="6">Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TBCC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854433">
        <property type="protein sequence ID" value="KAK4038289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PC89"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1250">
        <property type="entry name" value="Tubulin Binding Cofactor C, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017901">
        <property type="entry name" value="C-CAP_CF_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016098">
        <property type="entry name" value="CAP/MinC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006599">
        <property type="entry name" value="CARP_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027684">
        <property type="entry name" value="TBCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031925">
        <property type="entry name" value="TBCC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038397">
        <property type="entry name" value="TBCC_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012945">
        <property type="entry name" value="Tubulin-bd_cofactor_C_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15139">
        <property type="entry name" value="TUBULIN FOLDING COFACTOR C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15139:SF0">
        <property type="entry name" value="TUBULIN-SPECIFIC CHAPERONE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07986">
        <property type="entry name" value="TBCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16752">
        <property type="entry name" value="TBCC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00673">
        <property type="entry name" value="CARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51329">
        <property type="entry name" value="C_CAP_COFACTOR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-CAP/cofactor C-like" evidence="8">
        <location>
            <begin position="199"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="150"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00026055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4038289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="387" mass="41441" checksum="520BA21A052AEFC9" modified="2024-10-02" version="1">MGTMDPKERFYRQFQNSATTIQEQINQLSHTAAVPGERQDAVEHILSGISHLSSDVADATDFITAHDQRTYSDIVKSLKDQVNAAAAKWAPKSRFQFKKRAEKGGGGGGDAATAKPDTRRLDLAANNNNNNNPTDLASKPTTMEAKDITASGALPTVANTSTTANPAADGNVDSTGNPYFSSTRNITLADHNHVHITLPASSALAVSVGTLTNLERCVVDMTIPTTKTADADDEDMGCAPFASLTLKEIQGSVIVAGHVAGPVHVTGVRDSVVMVMARQVRIHECKNVVFYLHCVSRPIVEDCKGVRFAKAPGAFLTDKEKSEANLYDQVDDFKWLKTFSSPNWSLLPEAEVVPEAVWLKALAPGPGMAIGDTLRNLGAGKRAETES</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PCV8</accession>
    <name>A0AAN6PCV8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cysteine desulfurase</fullName>
            <ecNumber evidence="3">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">C8A01DRAFT_37794</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the removal of elemental sulfur from cysteine to produce alanine. It supplies the inorganic sulfur for iron-sulfur (Fe-S) clusters. Plays a role in both tRNA-processing and mitochondrial metabolism. Involved in the 2-thio-modification of both 5-carboxymethylaminomethyl-2-thiouridine in mitochondrial tRNAs and 5-methoxycarbonylmethyl-2-thiouridine (mcm5s2U) in cytoplasmic tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(sulfur carrier)-H + L-cysteine = (sulfur carrier)-SH + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:43892"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="2.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="3"/>
    <dbReference type="EMBL" id="MU854434">
        <property type="protein sequence ID" value="KAK4038277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PCV8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990221">
        <property type="term" value="C:L-cysteine desulfurase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034227">
        <property type="term" value="P:tRNA thio-modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000003">
        <property type="entry name" value="Cysteine desulfurase IscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000002">
        <property type="entry name" value="Cysteine desulfurase IscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00331">
        <property type="entry name" value="Cys_desulf_IscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010240">
        <property type="entry name" value="Cys_deSase_IscS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02006">
        <property type="entry name" value="IscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010611">
        <property type="entry name" value="PRK14012.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601:SF34">
        <property type="entry name" value="CYSTEINE DESULFURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601">
        <property type="entry name" value="CYSTEINE DESULFURYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="12">
        <location>
            <begin position="109"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK4038277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="508" mass="55329" checksum="B800BEFBD510D6EA" modified="2024-10-02" version="1">MANLAPSVLRQASRLASRPSVSAAPRRGVAALSRAATATARSACKRCYVTQTRPDNAQVQVDTAIRLDRAELEKAGVTLDAQSGSTTHVSPMADVLKQAVKLDEGQRPIYLDMQATTPLDPRVLDAMLPYYTGVFGNPHSRTHAYGWESEHAVEQAREYIAALIGADPKEIIFTSGATESNNMSIKGVARFFGRSGKKKHVITSQTEHKCVLDSCRHLQDEGYEVTYLPVNSNGLIDLDQLKAAIRPDTALVSIMAVNNEIGVIQPMAEIGKICRENKVFFHTDAAQAVGKIPLDVNAMNVDLMSISSHKIYGPKGIGACYVRRRPRVRLEPIISGGGQERGLRSGTLAPALVVGFGEACRIAAEEIEYDHKRVKALSDRLLNGLLAMEHTNQNGDPNHFYPGCVNVSFAYVEGESLLMALKDIALSSGSACTSASLEPSYVLRALGNSDENAHSSIRFGIGRFTTEAEIDYVLKAVTERVGFLRELSPLWELVQEGVDLNTIEWTQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PDM2</accession>
    <name>A0AAN6PDM2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GPI inositol-deacylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_37090</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854414">
        <property type="protein sequence ID" value="KAK4038973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF16">
        <property type="entry name" value="GPI INOSITOL-DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
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        <location>
            <begin position="84"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="5">
        <location>
            <begin position="372"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase winged helix" evidence="4">
        <location>
            <begin position="664"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
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        <location>
            <begin position="760"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
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        <location>
            <begin position="36"/>
            <end position="49"/>
        </location>
    </feature>
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        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4038973.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1638" mass="182641" checksum="35001B40106B9E16" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PDP2</accession>
    <name>A0AAN6PDP2_9PEZI</name>
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        <submittedName>
            <fullName evidence="9">Transcription factor atf1</fullName>
        </submittedName>
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        <name evidence="9" type="ORF">C8A01DRAFT_38052</name>
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        <name type="scientific">Parachaetomium inaequale</name>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
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    </comment>
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        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="bZIP"/>
    </dbReference>
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        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
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        <property type="entry name" value="TF_Aft1_HRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021756">
        <property type="entry name" value="TF_Aft1_HRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020956">
        <property type="entry name" value="TF_Aft1_OSM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19304">
        <property type="entry name" value="CYCLIC-AMP RESPONSE ELEMENT BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Aft1_HRR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Aft1_OSA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LEUZIPPRFOS"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
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        <location>
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            <end position="481"/>
        </location>
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            <end position="423"/>
        </location>
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    </evidence>
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        </source>
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        </source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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    <name>A0AAN6PDV6_9PEZI</name>
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            <fullName evidence="6">Transcriptional regulator of RNA polII, SAGA, subunit-domain-containing protein</fullName>
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        <name evidence="6" type="ORF">C8A01DRAFT_47312</name>
    </gene>
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            <taxon>Sordariomycetes</taxon>
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    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Hfi1/Tada1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <location>
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            <end position="147"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="406"/>
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        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023015"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023242"/>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK4039174.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="467" mass="50328" checksum="3EBEB71DADF9438D" modified="2024-10-02" version="1">MVDINPAALSRPSISLSTPVLSKQSINVSVPSIHKAPKTSQLIPARIELEPIYTALKAAIGAEQWSTYKEAITNFLIGRLNQAEFSERIDPILASPDGSREHLHNQLIAAVYGNVTREMPDQGLAPWVSANDKPSTTAGSKPVSGDAAERRLKGEVMQLPARDRRRIKDLVHNDFDPYESLANVFTDHARMRPAKTAEVPASAGGALSRMNFDLEIRKRYAQPLAVESGEFPDVSNIEARMLPFCYEAGLASGHAPDAAQFMSIATETFIKEVLGSIFSRTRSNPSGDSGNAGLGPGNNWVQTHKYRRQLAREEAAFHRGEVTRDKTGLLPVEAKAASERGPLGIADLRLALEIGDCGLANFPIISTSVIYGYREGELENWDDYTYVDGRDRITDLDGDVEMAGVNGSGNGSGNGNGNGTGKAPEPLTNGIGHGDQMDIDNDMWWEGGDMGDGNLLDGVLDSCLAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PE28</accession>
    <name>A0AAN6PE28_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_49296</name>
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    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854486">
        <property type="protein sequence ID" value="KAK4034277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PE28"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4034277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="327" mass="36785" checksum="4710C1BA0501084C" modified="2024-10-02" version="1">MELQSLSTSPSTPAVPNHSAPQPLSLSQLLQCSFDPPSSGDARRFQLRHEPPHGERRAAKLAYRMAPTYGCGFRERDIRDLLAPQDGPLKSIKGGFLFHYRRRPVGCLPGLAFSPRAESNNTHPLPVAVWTEFALIDELRCKAMRVGHAGRRRNPPVQRLDMLRWKAVTPVEPLHDPCILALLITVAQGQQIVVTQEQGQPDRPSYRSHVIWTDFDDQEHVHVFSADISSSFLYRFDFPGFVPPAPAFISIRHTTAPFKPYKTLYSRLLALILPDPHDTSRNDGKRKGETTDDGPRKMVPGQRHEDMDQSPEHGQSTRLAQQSQDEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PE88</accession>
    <name>A0AAN6PE88_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NAD-dependent protein deacetylase</fullName>
            <ecNumber evidence="6">2.3.1.286</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">C8A01DRAFT_36638</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N(6)-acetyl-L-lysyl-[protein] + NAD(+) + H2O = 2''-O-acetyl-ADP-D-ribose + nicotinamide + L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:43636"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="ChEBI" id="CHEBI:83767"/>
            <dbReference type="EC" id="2.3.1.286"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.286" evidence="6"/>
    <dbReference type="EMBL" id="MU854402">
        <property type="protein sequence ID" value="KAK4039347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PE88"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01408">
        <property type="entry name" value="SIRT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017328">
        <property type="entry name" value="Sirtuin_class_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF6">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037938">
        <property type="entry name" value="SIR2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 6 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6 8" id="KW-0520">NAD</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 6 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="13">
        <location>
            <begin position="15"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="341"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="308"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="341"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="395"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="412"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7 10">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="43"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="53"/>
            <end position="55"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="126"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 10">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 10">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 10">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="237"/>
            <end position="238"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="261"/>
            <end position="263"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR037938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR037938-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR037938-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR037938-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK4039347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="429" mass="46290" checksum="CBA7BF6862F18645" modified="2024-10-02" version="1">MGQEQSNITEDTPPLTLPERSLPAVADFIKSGKARRIVVMTGAGISTAAGIPDFRSPETGLYANLAALDLPEPEAVFDLSFFRQNPKPFYVLAKELYPGARYRPTVSHVFIALLARKGLLHMLFTQNIDCLERAAGVPADRIVEAHGSFASQRCIECKEVFEEGRMREFVARGEVPKCEREGQAQGVDGEAGAEAEKGVCGGLVKPDIVFFGEALPRAFFDSSGMAKEADLILVMGTSLQVHPFAGLPNMAEEETPRVLFNLEQVGSFGTRADDVMVLGDCDAGVRRLAEELGWRDELEKAWRELVGDEEAERQLQGATKRVAALHDEVSKLADEVEEVLHIDDKESGTGEETKDSQPDHETPAAVSTEDTEGSQGTGDGPAPKTTEPVVEPPEDQTNPSGSGHAENQSSAERGEKTVGDKDATEKAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PED7</accession>
    <name>A0AAN6PED7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_36990</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854411">
        <property type="protein sequence ID" value="KAK4039087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PED7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004631">
        <property type="term" value="F:phosphomevalonate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006695">
        <property type="term" value="P:cholesterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005919">
        <property type="entry name" value="Pmev_kin_anim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF25">
        <property type="entry name" value="PHOSPHOMEVALONATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04275">
        <property type="entry name" value="P-mevalo_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="323"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1071"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="16"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1074"/>
            <end position="1085"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4039087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1179" mass="127132" checksum="36B20BF0E6652B60" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PEH5</accession>
    <name>A0AAN6PEH5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">C8A01DRAFT_18378</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DeSI family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854462">
        <property type="protein sequence ID" value="KAK4034896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PEH5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01365">
        <property type="entry name" value="KISc_KIF1A_KIF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000050">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.30">
        <property type="entry name" value="PPPDE domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008580">
        <property type="entry name" value="PPPDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042266">
        <property type="entry name" value="PPPDE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013535">
        <property type="entry name" value="PUL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47117">
        <property type="entry name" value="STAR-RELATED LIPID TRANSFER PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05903">
        <property type="entry name" value="Peptidase_C97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08324">
        <property type="entry name" value="PUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM01179">
        <property type="entry name" value="DUF862"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51858">
        <property type="entry name" value="PPPDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51396">
        <property type="entry name" value="PUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPPDE" evidence="12">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="10">
        <location>
            <begin position="154"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="PUL" evidence="11">
        <location>
            <begin position="299"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="domain" description="Kinesin motor" evidence="9">
        <location>
            <begin position="651"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="948"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1133"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1058"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1135"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="755"/>
            <end position="762"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK4034896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1234" mass="135710" checksum="E65CE96ACAA1B434" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PEX2</accession>
    <name>A0AAN6PEX2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GMP synthase [glutamine-hydrolyzing]</fullName>
            <ecNumber evidence="4">6.3.5.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">GMP synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Glutamine amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">C8A01DRAFT_38788</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the conversion of xanthine monophosphate (XMP) to GMP in the presence of glutamine and ATP through an adenyl-XMP intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>XMP + L-glutamine + ATP + H2O = GMP + L-glutamate + AMP + diphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:11680"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.2" evidence="4"/>
    <dbReference type="EMBL" id="MU854467">
        <property type="protein sequence ID" value="KAK4034742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PEX2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003921">
        <property type="term" value="F:GMP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01742">
        <property type="entry name" value="GATase1_GMP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01997">
        <property type="entry name" value="GMP_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000017">
        <property type="entry name" value="GMP synthase [glutamine-hydrolyzing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000001">
        <property type="entry name" value="GMP synthase [glutamine-hydrolyzing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000001">
        <property type="entry name" value="GMP synthase [glutamine-hydrolyzing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00344">
        <property type="entry name" value="GMP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001674">
        <property type="entry name" value="GMP_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004739">
        <property type="entry name" value="GMP_synth_GATase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022955">
        <property type="entry name" value="GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025777">
        <property type="entry name" value="GMPS_ATP_PPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00884">
        <property type="entry name" value="guaA_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00888">
        <property type="entry name" value="guaA_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000848">
        <property type="entry name" value="PRK00074.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11922:SF2">
        <property type="entry name" value="GMP SYNTHASE [GLUTAMINE-HYDROLYZING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11922">
        <property type="entry name" value="GMP SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00958">
        <property type="entry name" value="GMP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00097">
        <property type="entry name" value="ANTSNTHASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00096">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54810">
        <property type="entry name" value="GMP synthetase C-terminal dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51553">
        <property type="entry name" value="GMPS_ATP_PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="8 16" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 16" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GMPS ATP-PPase" evidence="17">
        <location>
            <begin position="211"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="239"/>
            <end position="245"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAK4034742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="543" mass="59995" checksum="AC9CCFCCD68B9D77" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PEX5</accession>
    <name>A0AAN6PEX5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">C8A01DRAFT_16401</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854395">
        <property type="protein sequence ID" value="KAK4039656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PEX5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000149">
        <property type="entry name" value="MFS transporter, SP family, general alpha glucoside:H+ symporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF76">
        <property type="entry name" value="MALTOSE PERMEASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G07240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="317"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="351"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="380"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="407"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="445"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="475"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="59"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK4039656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="548" mass="60455" checksum="9D640849AEFF56F3" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PF75</accession>
    <name>A0AAN6PF75_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_16191</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854389">
        <property type="protein sequence ID" value="KAK4039864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PF75"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4039864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="256" mass="29201" checksum="EFA692CB6AD30911" modified="2024-10-02" version="1">MEIARAMLPCMPRRRGAQEGYTELVYDDKMAALYSDNEPYTQHDAMTYYDGDATDPITDYDNDYNEKHTPDVGRDVRTVEDVAAEVARLLWRAEWNDDALQGRISDAVGERRWNRKMVEECLDCVIEYVEQGRFEMGGAMCAALDRATDVADEEFAFPRRHPQSLDGFIAVVSVGVLAELQGAWVLELLGFGEVRGKQEMDGTGEIAMLTSDKIVFSPRFKSNSFAAWWAREYAAYIPEDSIYAYLNRMDMVEFED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PFF0</accession>
    <name>A0AAN6PFF0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_38482</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854457">
        <property type="protein sequence ID" value="KAK4035027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PFF0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF187">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="64"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="261"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="330"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="397"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="420"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="461"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="535"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="67"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="37"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4035027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="582" mass="62314" checksum="0F930B4834732569" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PGK0</accession>
    <name>A0AAN6PGK0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Lariat debranching enzyme, C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">C8A01DRAFT_15765</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the lariat debranching enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854379">
        <property type="protein sequence ID" value="KAK4040337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PGK0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008419">
        <property type="term" value="F:RNA lariat debranching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00844">
        <property type="entry name" value="MPP_Dbr1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007708">
        <property type="entry name" value="DBR1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041816">
        <property type="entry name" value="Dbr1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12849:SF0">
        <property type="entry name" value="LARIAT DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12849">
        <property type="entry name" value="RNA LARIAT DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05011">
        <property type="entry name" value="DBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01124">
        <property type="entry name" value="DBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Lariat debranching enzyme C-terminal" evidence="14">
        <location>
            <begin position="350"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="249"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="295"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="507"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="249"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="272"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="519"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK4040337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="569" mass="62215" checksum="826C0F6D223DDF36" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PGQ2</accession>
    <name>A0AAN6PGQ2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_35647</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854379">
        <property type="protein sequence ID" value="KAK4040317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PGQ2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4040317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="265" mass="29251" checksum="D2C4F1FF0AAD72F9" modified="2024-10-02" version="1">MATVKLRLKNYAFRLPTGGDSDDDDYDAWAASFNSALTKLAATLRRCSRMRSLDVEVRVGGLLDHQAYLMAEPVADLLSVGRLTSLTFDSATCLFSRTPESGVHFCRSINALLPSLRRLRFRMESVCKSLLEPPPGDAPLALEEVIVNLSLSQLNHAITSVRHSRCCGDVAGTAFVQFKNALEAQATALAARLRQPRMVRIITHEFPSLDFYAFDALTGKRILLEDNIEWDAEGEAEDDAEADATEDDESDLFADEPPVTPFIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PH64</accession>
    <name>A0AAN6PH64_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_34986</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854366">
        <property type="protein sequence ID" value="KAK4040929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PH64"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4040929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="305" mass="33007" checksum="A0B9E2E2554A45F3" modified="2024-10-02" version="1" fragment="single">MGTSYIAPDLPGQAQAGTMELSDVYEYAPYSDDMDELALYPVPGMPVTDMDMELLSSITANGFLDHDACNSSPAIPIPEAHEAKYFDFSAVSSHTFGKGKSNYPRVFPSHDDKTCRTQNGSEMPLFPENSGWGPTNAEPETWNPYYKYNTTASSYHTPGYADHYPSTDGGNNVTPGRGSDVTIHLHNNLSAKTIPVRGLLDSGNQFGALISLNTALKLGYRPRDFNGGPRVLQSVGGHEHVTAGSIPIRYYLGDDSHNPHDANFHVLQVLAGGYDVNLPTQGVVIDPGMIPVAAFLVTAKREPTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PHG1</accession>
    <name>A0AAN6PHG1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_46496</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854384">
        <property type="protein sequence ID" value="KAK4040095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PHG1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF10">
        <property type="entry name" value="L-ORNITHINE N(5)-OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="879"/>
            <end position="898"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4040095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="935" mass="103017" checksum="4482D7733834BD3D" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PHI9</accession>
    <name>A0AAN6PHI9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_35800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854382">
        <property type="protein sequence ID" value="KAK4040198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PHI9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="943"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1003"/>
            <end position="1018"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4040198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1211" mass="131174" checksum="78FEEBAEF6B3B4B9" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PHM9</accession>
    <name>A0AAN6PHM9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_16635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854402">
        <property type="protein sequence ID" value="KAK4039361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PHM9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="224"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="298"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="373"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4039361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="419" mass="43264" checksum="0E31BE2D29BF740B" modified="2024-10-02" version="1">MSAYYEPSQWPPSGQSGWDHQTPPPARSGASSTIPREESAAFTHQLEEVDRAIDNLVKSGKMFGGAGGRRESLPHPGPARTYPAREGRPPAGPGSRPHSMAADFGDARGSHPGSNLQNFYASQRHQSSRGSNEAEQMMQAKRRMAAQRERELRNYHQEQQYNRTVLADMSYGSNKSDRAMSPGSLSDEDRRKLIAQQRSALYGEGPYPEGAAVYADEAGAPRTGLPGPQAGPAGLRGHSPLAYEYGRAPPVHPDAGAQASAEGNQGSQSAGPNEQARATSNSSPQSNPGSKGMYDAPAVQQSSRTSVSSPGGSPPRQGAPGSKPSQGSVAPIGTRPSVSGAPTNPALSKRSTTPLPSPLSQGYSASGNGEGGASSSAAPPKPSAAAAAEGSNIGLSGWGARPNGWGSKPGLGVQASVWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PHN6</accession>
    <name>A0AAN6PHN6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">O-acyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">C8A01DRAFT_35095</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Sterol O-acyltransferase that catalyzes the formation of stery esters.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854367">
        <property type="protein sequence ID" value="KAK4040922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PHN6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014371">
        <property type="entry name" value="Oat_ACAT_DAG_ARE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408:SF7">
        <property type="entry name" value="DIACYLGLYCEROL O-ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408">
        <property type="entry name" value="STEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000439">
        <property type="entry name" value="Oat_ACAT_DAG_ARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="152"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="438"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="467"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="506"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR000439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000439-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK4040922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="547" mass="61610" checksum="4241B9D248C158F7" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PHY7</accession>
    <name>A0AAN6PHY7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA repair protein RAD14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">C8A01DRAFT_47529</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854416">
        <property type="protein sequence ID" value="KAK4038890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PHY7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="DBD_Rad14"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Dna repair rad14 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.530.10">
        <property type="entry name" value="XPA C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013258">
        <property type="entry name" value="Striatin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051488">
        <property type="entry name" value="WD_repeat_striatin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000465">
        <property type="entry name" value="XPA/RAD14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022656">
        <property type="entry name" value="XPA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022658">
        <property type="entry name" value="XPA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037129">
        <property type="entry name" value="XPA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00598">
        <property type="entry name" value="rad14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15653:SF0">
        <property type="entry name" value="CONNECTOR OF KINASE TO AP-1, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15653">
        <property type="entry name" value="STRIATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08232">
        <property type="entry name" value="Striatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05181">
        <property type="entry name" value="XPA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="Putative DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00753">
        <property type="entry name" value="XPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0853">WD repeat</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="XPA C-terminal" evidence="15">
        <location>
            <begin position="239"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Striatin N-terminal" evidence="16">
        <location>
            <begin position="468"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="989"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="1191"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="139"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="332"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="436"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="541"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="667"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1010"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1135"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="487"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="442"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="541"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="741"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="806"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1010"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1035"/>
            <end position="1057"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00072989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF05181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF08232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAK4038890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1270" mass="137365" checksum="B49FFDB87990DC74" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PIF6</accession>
    <name>A0AAN6PIF6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">PUL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_16305</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010992">
        <property type="term" value="P:ubiquitin recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000236">
        <property type="entry name" value="Polyubiquitin binding protein (Doa1/Ufd3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.870">
        <property type="entry name" value="PFU (PLAA family ubiquitin binding), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015155">
        <property type="entry name" value="PFU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038122">
        <property type="entry name" value="PFU_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013535">
        <property type="entry name" value="PUL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849">
        <property type="entry name" value="PHOSPHOLIPASE A-2-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849:SF0">
        <property type="entry name" value="PHOSPHOLIPASE A-2-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09070">
        <property type="entry name" value="PFU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08324">
        <property type="entry name" value="PUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51394">
        <property type="entry name" value="PFU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51396">
        <property type="entry name" value="PUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="10"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="105"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="243"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="PFU" evidence="7">
        <location>
            <begin position="383"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="PUL" evidence="8">
        <location>
            <begin position="502"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="475"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="490"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4039736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="807" mass="87499" checksum="BA823930DBEFBBD4" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PIM3</accession>
    <name>A0AAN6PIM3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">alkaline phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_14600</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="3">Binds 1 Mg(2+) ion.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 2 Zn(2+) ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the alkaline phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.1" evidence="1"/>
    <dbReference type="EMBL" id="MU854353">
        <property type="protein sequence ID" value="KAK4041679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PIM3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004035">
        <property type="term" value="F:alkaline phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16012">
        <property type="entry name" value="ALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001952">
        <property type="entry name" value="Alkaline_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11596">
        <property type="entry name" value="ALKALINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11596:SF72">
        <property type="entry name" value="ALKALINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00245">
        <property type="entry name" value="Alk_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00113">
        <property type="entry name" value="ALKPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00098">
        <property type="entry name" value="alkPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042972719" description="alkaline phosphatase" evidence="5">
        <location>
            <begin position="22"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="2">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="439"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="444"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="448"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="489"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="490"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="612"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601952-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601952-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4041679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="666" mass="72013" checksum="EDFDCC22544361DF" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PJS2</accession>
    <name>A0AAN6PJS2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Necrosis inducing protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_15699</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854377">
        <property type="protein sequence ID" value="KAK4040426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PJS2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008701">
        <property type="entry name" value="NPP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33657">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G00600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33657:SF6">
        <property type="entry name" value="SECRETED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05630">
        <property type="entry name" value="NPP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042928805" evidence="1">
        <location>
            <begin position="22"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4040426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="311" mass="34667" checksum="00E38D41A4A670E5" modified="2024-10-02" version="1">MPPLQKIAAAAALVLSLPSLAAVIQRSANETARILNNRDAEPLHPVADGLDWAPNFQLKFQPLVDFDTDSCYNVPAMDAQGTASSGLEPSSSVGPCRPRSALDRGGSNVYVRGRCNRGWCALVFAYYFQMDWAWGWPFSSYNHRHDWEHVVVWAKQGQVRSVSVSCHGDYESCVAGDDRLRFGSTPNEFPYPSPGPAPAAMHPKVVFHKDGVRTHCFRFAKDSDDYEGQENDRGVWIRSGLVGMLMMPTDWVEKLRSHDWGSAHLAWASEDGFTGHLVETMPQEARNDEFDCAYDEIPGVQGFPSDLEKWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PKP9</accession>
    <name>A0AAN6PKP9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mo25-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_13646</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Mo25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854336">
        <property type="protein sequence ID" value="KAK4042774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PKP9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000257">
        <property type="entry name" value="Conidiophore development protein hymA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013878">
        <property type="entry name" value="Mo25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10182">
        <property type="entry name" value="CALCIUM-BINDING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10182:SF3">
        <property type="entry name" value="PROTEIN MO25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08569">
        <property type="entry name" value="Mo25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4042774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="372" mass="42801" checksum="361DAF59926B0EF3" modified="2024-10-02" version="1">MSFFFGRARARTNTTDLAKQARDHVTKLEGPQGAAKADELAKVLAQMKQVLQGTHADAEPNTEQIYQLVTGMIEEDLLYLLAVHLHRLPFESRKDTQVIFSYIFRFRPPTGPQKPEPFALAYVVERRPQVLVELCRGYDHKESATPAGTVLREVLKNEAAAAIILYDDGEEQGSSARGVGGINPDRPQSGRGVFWNFFDWIDKSSFEVSADAFTTFRELITKHKDLVPRYLAVNFDLFFDRYNKVLVQSNSYVTKRQSIKLLGEILLDRANYNIMTAYVDRGEHLKICMNLLRDDRKMVQYEGFHVFKVFVANPHKSVPVQKILIMNRDKLLQFLSHFLEDRTEDEQFIDEREFLIKQIRNLPPAPVPPPQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PL12</accession>
    <name>A0AAN6PL12_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pre-rRNA-processing protein IPI3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_14375</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the RIX1 complex, composed of IPI1, RIX1/IPI2 and IPI3 in a 1:2:2 stoichiometry. The complex interacts (via RIX1) with MDN1 (via its hexameric AAA ATPase ring) and the pre-60S ribosome particles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the WD repeat IPI3/WDR18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854348">
        <property type="protein sequence ID" value="KAK4041970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PL12"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120330">
        <property type="term" value="C:rixosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000929">
        <property type="entry name" value="Ribosomal assembly complex component Ipi3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045227">
        <property type="entry name" value="WDR18/Ipi3/RID3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18763:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18763">
        <property type="entry name" value="WD-REPEAT PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 5 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="122"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="171"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU369067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4041970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="437" mass="47236" checksum="4B024EBCEA45E3DA" modified="2024-10-02" version="1">MLSEEFVSAICGAPLSSNTAIAKDVGIYCHTLSPTYSVKSTFKKSSVPVNCLGVSDSHVFAAQHEKAYVHVYSRLRGNQEAFVAFPERIRCLTLAGDVLVMGTTEGRLMLWETCTGRLVSTPARHVQAVSCVAATPYHVLTGSDDSDIHVWSLPQLLELDSAAEHEPQRSLSNHRAAITGLSVSPSVSSDTNFCVSASKDKSCIIWNYQTGDALRTLLFPSFPLCLSLDPSSRAVCVSCEDGSIYLAEVFAEKPLLGPGSEEATTVVQVSSPFGATQPDVGPASCLSLSYDGTMLLTGHPKGQIMRWDIAENKSPVELANLNAAVTNIAFVSPFPADQPTKTVTIIKPSQAERAYTFAVQFDSYAGPETRFDSLLNAAGFPQEAMESVIAAFNQPAAESAADQDLQKQNEELWEIINEQRALQKQTLQRYVEAKSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PLA7</accession>
    <name>A0AAN6PLA7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">S-methyl-5'-thioadenosine phosphorylase</fullName>
            <ecNumber evidence="4">2.4.2.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">5'-methylthioadenosine phosphorylase</fullName>
            <shortName evidence="4">MTA phosphorylase</shortName>
            <shortName evidence="4">MTAP</shortName>
            <shortName evidence="4">MTAPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_43915</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>S-methyl-5'-thioadenosine + phosphate = 5-(methylsulfanyl)-alpha-D-ribose 1-phosphate + adenine</text>
            <dbReference type="Rhea" id="RHEA:11852"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58533"/>
            <dbReference type="EC" id="2.4.2.28"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (phosphorylase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.28" evidence="4"/>
    <dbReference type="EMBL" id="MU854331">
        <property type="protein sequence ID" value="KAK4043134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PLA7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017061">
        <property type="term" value="F:S-methyl-5-thioadenosine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09010">
        <property type="entry name" value="MTAP_SsMTAPII_like_MTIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1580:FF:000008">
        <property type="entry name" value="S-methyl-5'-thioadenosine phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01963">
        <property type="entry name" value="MTAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010044">
        <property type="entry name" value="MTAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018099">
        <property type="entry name" value="Purine_phosphorylase-2_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01694">
        <property type="entry name" value="MTAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42679">
        <property type="entry name" value="S-METHYL-5'-THIOADENOSINE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42679:SF2">
        <property type="entry name" value="S-METHYL-5'-THIOADENOSINE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01240">
        <property type="entry name" value="PNP_MTAP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 4" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="5">
        <location>
            <begin position="18"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="66"/>
            <end position="67"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="99"/>
            <end position="100"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="225"/>
            <end position="227"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="4">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="4">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4043134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="311" mass="33572" checksum="FE775EE396FB1771" modified="2024-10-02" version="1">MTVDILSLPTHFDRPVHIAVIGGTGLSSLPGYHPVAALSPTTPWGAPSSPILILEHAGVPVAFLARHGIHHQLAPHEVPARANIAALRALGVRTVIAFSAVGSLQEAIKPMDFVVPDQIIDRTKGIRPFTFFEGGVVGHVGFADPFDAGLAGIVQRCAASMRGDGVTLHNKGTIVCMEGPQFSTRAESHMYRSWGGSVINMSALPEAKLAREAELAYQMICMATDYDCWHSSEDVDVAMVMKYMAANSENAKHLVGAVLDELCKQENSELVLAKQWEGSAQGAVKFMTKPAGRDPEAMKRVEYLFPGFWNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PLM9</accession>
    <name>A0AAN6PLM9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_32701</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854330">
        <property type="protein sequence ID" value="KAK4043211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PLM9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053203">
        <property type="entry name" value="Cisplatin_resist-associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022024">
        <property type="entry name" value="DUF3602"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34693">
        <property type="entry name" value="PROTEIN PAR32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34693:SF1">
        <property type="entry name" value="PROTEIN PAR32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12223">
        <property type="entry name" value="DUF3602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="105"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4043211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="172" mass="17607" checksum="CC06C4FF61B60719" modified="2024-10-02" version="1">MSTDVFRRVGRGGAGNFYSKQDIQDAEKASNEQSKTQDVEAQTHTSVSGSGSVSGSGSGSAPNYARAGRGGVGNFTFPATDPSTTPDPDTAKQNEEEAEADRAKAAAAVAASLAAKSKAGGLSGRGGAGNWTGGGGEKDQEEEQKRAEEVERMVLRDVAVGLAAPARVYTPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PLU7</accession>
    <name>A0AAN6PLU7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">C8A01DRAFT_35140</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the DEAD box helicase family. DDX48/FAL1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="MU854368">
        <property type="protein sequence ID" value="KAK4040870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PLU7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18045">
        <property type="entry name" value="DEADc_EIF4AIII_DDX48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000031">
        <property type="entry name" value="Eukaryotic initiation factor 4A-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000498">
        <property type="entry name" value="Eukaryotic initiation factor 4A-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 15 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="18">
        <location>
            <begin position="27"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="58"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="239"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="14">
        <location>
            <begin position="27"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAK4040870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="401" mass="45479" checksum="0DD27853BBC4130D" modified="2024-10-02" version="1">MADAAGIDRKADEKIQFSTSKEVTVHPTFESMSLKESLLRGIYAYGYESPSAVQSRAIVQVCKGRDTIAQAQSGTGKTATFSISMLQVIDTAVRETQALVLSPTRELATQIQSVVMALGDYMNVQCHACIGGTNVGEDIRKLDYGQHIVSGTPGRVADMIRRRHLRTRHIKMLVLDEADELLNQGFREQIYDVYRYLPPATQVVVVSATLPYDVLDMTTKFMTDPVRILVKRDELTLEGLKQYFIAVEKEDWKFDTLCDLYDTLTITQAVIFCNTRRKVDWLTDKMREANFTVSSMHGDMPQKERDSIMQDFRQGNSRVLISTDVWARGIDVQQVSLVINYDLPSNRENYIHRIGRSGRFGRKGVAINFVTSEDVRILRDIELYYSTQIDEMPMNVADLIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PLX9</accession>
    <name>A0AAN6PLX9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heterokaryon incompatibility protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_14957</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854360">
        <property type="protein sequence ID" value="KAK4041296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PLX9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF73">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G01020)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26639">
        <property type="entry name" value="Het-6_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="182"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4041296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="867" mass="97533" checksum="1FDF3ED1858F70B3" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PM25</accession>
    <name>A0AAN6PM25_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UPF0047 protein C4A8.02c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_43648</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0047 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854327">
        <property type="protein sequence ID" value="KAK4043524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PM25"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.460">
        <property type="entry name" value="YjbQ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001602">
        <property type="entry name" value="UPF0047_YjbQ-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035917">
        <property type="entry name" value="YjbQ-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00149">
        <property type="entry name" value="TIGR00149_YjbQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30615">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN YJBQ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30615:SF8">
        <property type="entry name" value="UPF0047 PROTEIN C4A8.02C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01894">
        <property type="entry name" value="YjbQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111038">
        <property type="entry name" value="YjbQ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01314">
        <property type="entry name" value="UPF0047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="22"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4043524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="220" mass="24329" checksum="F2D927E2FAEF3472" modified="2024-10-02" version="1">MPGRHSLSTTCHGLLPTTTTTLILFVLLILCLFPTTFHLLWTLPFSLLFPSPHHTKQQPSPPPGPGGAITAETKTMWFQKQFSLPARARGSYLITDTVLEQLPEIRAYKVGLLHLFVQHTSCALSLNENWDEDVRADMSDTLDKIVPEAGPKGEALYRHDAEGPDDLPAHVKSALIGASVTIPIKDGKLATGTWQGIWYLEFRAMKHTRKIVATIQGEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PMQ2</accession>
    <name>A0AAN6PMQ2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phosphoadenylyl-sulfate reductase (thioredoxin)</fullName>
            <ecNumber evidence="3">1.8.4.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">3'-phosphoadenylylsulfate reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">PAPS reductase, thioredoxin dependent</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">PAdoPS reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">C8A01DRAFT_32131</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>[thioredoxin]-disulfide + sulfite + adenosine 3',5'-bisphosphate + 2 H(+) = [thioredoxin]-dithiol + 3'-phosphoadenylyl sulfate</text>
            <dbReference type="Rhea" id="RHEA:11724"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="EC" id="1.8.4.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PAPS reductase family. CysH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.8" evidence="3"/>
    <dbReference type="EMBL" id="MU854324">
        <property type="protein sequence ID" value="KAK4043811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PMQ2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004604">
        <property type="term" value="F:phosphoadenylyl-sulfate reductase (thioredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019344">
        <property type="term" value="P:cysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019379">
        <property type="term" value="P:sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23945">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000151">
        <property type="entry name" value="Phosphoadenosine phosphosulfate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00063">
        <property type="entry name" value="CysH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004511">
        <property type="entry name" value="PAPS/APS_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011800">
        <property type="entry name" value="PAPS_reductase_CysH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00434">
        <property type="entry name" value="cysH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02057">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002537">
        <property type="entry name" value="PRK02090.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46509">
        <property type="entry name" value="PHOSPHOADENOSINE PHOSPHOSULFATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46509:SF1">
        <property type="entry name" value="PHOSPHOADENOSINE PHOSPHOSULFATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000857">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="7" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphoadenosine phosphosulphate reductase" evidence="14">
        <location>
            <begin position="70"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00052536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00078053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00082472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00082553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK4043811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="300" mass="33673" checksum="A6AB06FBC678EC97" modified="2024-10-02" version="1">MADDAHTETSSQSSGDHGSVDSGFVSPSTSTVSLPRISLTQPHLKHLNKQLESLHPMDVLRFCKIFFPNLYQSTAFGLTGLVTVDMLSKLDAESPSATPQPVDLIFLDTLYHFQETYDLVERVRERYGVRVHVFKPADVDTVGQFEELYGEKLYDMSAELYDWIAKVEPLQRAYSELKVAAVLTGRRRSQGGQRGDISVLELDDERGVIKINPLANWSFAQVKAYVDEHKVPYNALLDRGYKSIGDWHSTVPVGEGEDERAGRWKGQAKTECGIHNKQSRYAQWLEKSALQQQGQEVPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PMQ4</accession>
    <name>A0AAN6PMQ4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_12907</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854326">
        <property type="protein sequence ID" value="KAK4043602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PMQ4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052109">
        <property type="entry name" value="SRRM_Domain-Containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34755:SF4">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34755">
        <property type="entry name" value="SERINE/ARGININE REPETITIVE MATRIX PROTEIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="616"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="744"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="686"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="704"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="749"/>
            <end position="776"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4043602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="776" mass="85023" checksum="F23C863661D41FC1" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PNN9</accession>
    <name>A0AAN6PNN9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Alpha-L-arabinofuranosidase</fullName>
            <ecNumber evidence="11">3.2.1.55</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">C8A01DRAFT_43045</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Alpha-L-arabinofuranosidase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>Hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides.</text>
            <dbReference type="EC" id="3.2.1.55"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the glycosyl hydrolase 62 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.55" evidence="11"/>
    <dbReference type="EMBL" id="MU854321">
        <property type="protein sequence ID" value="KAK4044112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PNN9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046373">
        <property type="term" value="P:L-arabinose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08987">
        <property type="entry name" value="GH62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005193">
        <property type="entry name" value="GH62_arabinosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40631">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE AXHA-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40631:SF1">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE AXHA-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03664">
        <property type="entry name" value="Glyco_hydro_62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 11 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 11 13" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042880037" description="Alpha-L-arabinofuranosidase" evidence="13">
        <location>
            <begin position="22"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="14">
        <location>
            <begin position="346"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="319"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="329"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK4044112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="382" mass="40134" checksum="87A7E07052D706A6" modified="2024-10-02" version="1">MRLTKTDGLIALLAALPVAQGACSLPSTYKWTSSGALANPKSGWANLKDFTHVPYNGKHLVYASYYGSAYGSMNFGLFSDWSSMGSASQNGMSSAAVAPTLFYFAPKSTWVLAYQWGATAFSYRTSSDPTNANGWSAAQPLFSGTISGSDTGPIDQTLIGDSTNMYLFFAGDNGSIYRASMPIGNFPGNFGTASTVVLSGSRNDFFEAVQVYTVGGQSSPQYLMIIESMGSQGRYFRSYTATSLGGSWTAQAASESAPFAGKANSGATWTSDISHGDLIRSNADQTFTIDPCNLQLLYQGRSGDSSDYNSLPYRPGLLTLQGASGGGSTPTTTTAPSTPSGGGGTGTAKHYEQCGGQGYSGPTACESPYKCTFSNQWYSQCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PPE4</accession>
    <name>A0AAN6PPE4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Oleate activated transcription factor 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_44713</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854344">
        <property type="protein sequence ID" value="KAK4042190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PPE4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF58">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="39"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="77"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="386"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="452"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4042190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="667" mass="73760" checksum="4F7BBB5C782762D8" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PPV9</accession>
    <name>A0AAN6PPV9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Carboxypeptidase</fullName>
            <ecNumber evidence="7">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_13374</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="7"/>
    <dbReference type="EMBL" id="MU854332">
        <property type="protein sequence ID" value="KAK4043079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PPV9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000118">
        <property type="entry name" value="Carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033124">
        <property type="entry name" value="Ser_caboxypep_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF479">
        <property type="entry name" value="CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00560">
        <property type="entry name" value="CARBOXYPEPT_SER_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042665675" description="Carboxypeptidase" evidence="7">
        <location>
            <begin position="19"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="535"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="560"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4043079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="569" mass="62624" checksum="7F226DC6CB470A19" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PQ85</accession>
    <name>A0AAN6PQ85_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Lactation elevated protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_44360</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AFG1 ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854338">
        <property type="protein sequence ID" value="KAK4042610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PQ85"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005654">
        <property type="entry name" value="ATPase_AFG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006598">
        <property type="entry name" value="CAP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12169:SF2">
        <property type="entry name" value="AFG1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12169">
        <property type="entry name" value="ATPASE N2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03969">
        <property type="entry name" value="AFG1_ATPase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05686">
        <property type="entry name" value="Glyco_transf_90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00672">
        <property type="entry name" value="CAP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl transferase CAP10" evidence="5">
        <location>
            <begin position="690"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="521"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4042610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1006" mass="112918" checksum="0FBD1D6D74F4018A" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PQJ5</accession>
    <name>A0AAN6PQJ5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_42805</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854319">
        <property type="protein sequence ID" value="KAK4044370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PQJ5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052897">
        <property type="entry name" value="Sec-Metab_Biosynth_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017:SF13">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043006262" evidence="1">
        <location>
            <begin position="23"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="27"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4044370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="271" mass="28725" checksum="B3D2DE2AF06B2D96" modified="2024-10-02" version="1">MFSSLSHTFVLALSVVSAMAAATKPTIVIVPGSWQLPSVWDEFRAVLSRAGHQTYHVALPSVGGTELPLTGLPEDVAAVQHVVGGLADHGDEIVLLCHSSGGVVGSNAVEGYDVATRKAAGKVGGVVRIVYLSAFMLPKDESLLGMLGGVPLPWMVVDGDRVTGDPDMMPEIGFNDLPADEQAYWAQQVTWTSAALFAAPSQFEPWNNGIPGAYIFQTIDNALPYELQQGMAQQLQLGPDPRNATMESGHCGFLSMPERLLGALKQVIGSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PR41</accession>
    <name>A0AAN6PR41_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Clathrin heavy chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_12190</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasmic vesicle membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <location evidence="6">Coated pit</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the clathrin heavy chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854319">
        <property type="protein sequence ID" value="KAK4044428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030132">
        <property type="term" value="C:clathrin coat of coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030130">
        <property type="term" value="C:clathrin coat of trans-Golgi network vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071439">
        <property type="term" value="C:clathrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032051">
        <property type="term" value="F:clathrin light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006898">
        <property type="term" value="P:receptor-mediated endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000001">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000002">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000005">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000082">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.730:FF:000003">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.110:FF:000003">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.110">
        <property type="entry name" value="Clathrin heavy-chain terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055358">
        <property type="entry name" value="CHCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016025">
        <property type="entry name" value="Clathrin_H-chain_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022365">
        <property type="entry name" value="Clathrin_H-chain_propeller_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016341">
        <property type="entry name" value="Clathrin_heavy_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10292:SF1">
        <property type="entry name" value="CLATHRIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10292">
        <property type="entry name" value="CLATHRIN HEAVY CHAIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00637">
        <property type="entry name" value="Clathrin"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13838">
        <property type="entry name" value="Clathrin_H_link"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01394">
        <property type="entry name" value="Clathrin_propel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002290">
        <property type="entry name" value="Clathrin_H_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00299">
        <property type="entry name" value="CLH"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50989">
        <property type="entry name" value="Clathrin heavy-chain terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0168">Coated pit</keyword>
    <keyword evidence="5 6" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="3 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="538"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="690"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="838"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="984"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="1133"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="1279"/>
            <end position="1425"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="1428"/>
            <end position="1571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4044428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1677" mass="189754" checksum="2BB1989DB5CC38EE" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PRB3</accession>
    <name>A0AAN6PRB3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glycerophosphoryl diester phosphodiesterase family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_32258</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
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            <taxon>Sordariomycetidae</taxon>
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    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
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                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
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                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
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                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1089"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1134"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1206"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1223"/>
            <end position="1232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4043675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1409" mass="152416" checksum="A0DC8E6BB21D5F4C" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SKG1</accession>
    <name>A0AAN6SKG1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heterokaryon incompatibility protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_21148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854729">
        <property type="protein sequence ID" value="KAK4031676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SKG1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="12"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4031676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="262" mass="29785" checksum="B4F5D00D58377DF5" modified="2024-10-02" version="1">MCTYQTNSLPKYVALSYTWGPPQQDAIGYGPDDKVPVLVNGRPLPLFRNLGNTLKSLYRAWDFDDDVQHLWVDAICINQDDEAERASQVNIMDRIYRGAASTCVWLGEESRSQTTAPIFRNILNAASEDFAPYYHQYPSGTPPADVFWHSKGLPCPDDEGQWAPVRRLFQNRWFNRAWVIQEVLLSSNIYVSWGSTWMTWDDLGKMGLMGHVAKLGQHGALPALFQHLSGESTHPEPETQDWAAHDPVTSALHLWLNGHRYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SLT1</accession>
    <name>A0AAN6SLT1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alpha-1,3-glucosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">C8A01DRAFT_41744</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2 10">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the ALG6/ALG8 glucosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="MU854697">
        <property type="protein sequence ID" value="KAK4031815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SLT1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042281">
        <property type="term" value="F:dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004856">
        <property type="entry name" value="Glyco_trans_ALG6/ALG8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413">
        <property type="entry name" value="DOLICHYL GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413:SF1">
        <property type="entry name" value="DOLICHYL PYROPHOSPHATE MAN9GLCNAC2 ALPHA-1,3-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03155">
        <property type="entry name" value="Alg6_Alg8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="222"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="412"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="485"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="514"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="548"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK4031815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="594" mass="66618" checksum="77D72C75C9EB4D00" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SLZ6</accession>
    <name>A0AAN6SLZ6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_50683</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoA-transferase III family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854597">
        <property type="protein sequence ID" value="KAK4032549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SLZ6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047369">
        <property type="term" value="F:succinate-hydroxymethylglutarate CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15502">
        <property type="entry name" value="PHD_Phf1p_Phf2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1540.10:FF:000005">
        <property type="entry name" value="succinate--hydroxymethylglutarate CoA-transferase isoform X4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="entry name" value="Crotonobetainyl-coa:carnitine coa-transferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="entry name" value="formyl-coa transferase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050483">
        <property type="entry name" value="CoA-transferase_III_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48207">
        <property type="entry name" value="SUCCINATE--HYDROXYMETHYLGLUTARATE COA-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48207:SF3">
        <property type="entry name" value="SUCCINATE--HYDROXYMETHYLGLUTARATE COA-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="CoA-transferase family III (CaiB/BaiF)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="8">
        <location>
            <begin position="659"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="481"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="539"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="721"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="838"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="485"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="503"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="572"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="583"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="601"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="721"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="745"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="846"/>
            <end position="857"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4032549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="919" mass="98569" checksum="CBAD4AA68E3B0556" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SMH3</accession>
    <name>A0AAN6SMH3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mutanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_41000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854596">
        <property type="protein sequence ID" value="KAK4032565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SMH3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051118">
        <property type="term" value="F:glucan endo-1,3-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11577">
        <property type="entry name" value="GH71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005197">
        <property type="entry name" value="Glyco_hydro_71"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03659">
        <property type="entry name" value="Glyco_hydro_71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042955885" evidence="1">
        <location>
            <begin position="22"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4032565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1206" mass="127624" checksum="90F0D626E99BCC62" modified="2024-10-02" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SML9</accession>
    <name>A0AAN6SML9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor IIF subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">TFIIF medium subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">TFIIF-beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">C8A01DRAFT_19119</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIF beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854499">
        <property type="protein sequence ID" value="KAK4034001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SML9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005674">
        <property type="term" value="C:transcription factor TFIIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07980">
        <property type="entry name" value="TFIIF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000035">
        <property type="entry name" value="General transcription factor IIF subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003196">
        <property type="entry name" value="TFIIF_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040450">
        <property type="entry name" value="TFIIF_beta_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040504">
        <property type="entry name" value="TFIIF_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011039">
        <property type="entry name" value="TFIIF_interaction"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10445">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10445:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02270">
        <property type="entry name" value="TFIIF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17683">
        <property type="entry name" value="TFIIF_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50916">
        <property type="entry name" value="Rap30/74 interaction domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TFIIF beta subunit N-terminal" evidence="12">
        <location>
            <begin position="39"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIF beta subunit HTH" evidence="11">
        <location>
            <begin position="247"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="321"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="331"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00081473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00081863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK4034001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="346" mass="39873" checksum="0EA51E65702D60D9" modified="2024-10-02" version="1">MAEPQIKPEPDTGSPFMDEVDETPDLEFYDRLPDADAYSRMYLTRLPNYVWEAWSKLDDDAEIEIGTIRQWMDETGKMRLQMRLKPEMEAHKEVPKEYDMDVSNHDVNNTFVFTEQDLPSYAAKNKERANALAQGIPAHLLRKQQRQMEQPADRARKGAPYSRRPIPKKTRIAGRIKHEVVCTPVRNAEADRFLSIRAAAAQQPQKKVTMVQGFPTGDTTNPNEWDAFLKTREKPTKAKKMENKATRWPENQLLDAIARCFSEHKYWSVKAFRGRIQQPEAYLRETLDKIALLHRSGTFANHWSLKPEYEGIMASLPKPADDAAVARADVPSDDEEDEDIKMEDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SMM0</accession>
    <name>A0AAN6SMM0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Iron-sulfur cluster assembly factor IBA57 homolog, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_19785</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the GcvT family. CAF17/IBA57 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854543">
        <property type="protein sequence ID" value="KAK4033239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SMM0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="entry name" value="Probable tRNA modification gtpase trme, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017703">
        <property type="entry name" value="YgfZ/GCV_T_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045179">
        <property type="entry name" value="YgfZ/GcvT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03317">
        <property type="entry name" value="ygfZ_signature"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22602">
        <property type="entry name" value="TRANSFERASE CAF17, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22602:SF0">
        <property type="entry name" value="TRANSFERASE CAF17, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103025">
        <property type="entry name" value="Folate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00093447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00093637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4033239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="424" mass="45859" checksum="9B92FF3DCEF658E4" modified="2024-10-02" version="1">MQPARRVLASTGAASAVRSPGAFTCRACLTRLPAPQRRSFSRSAPRHAAPPGPVPAGLAELSSRKLISVSGPDAAKYLQGVITANLFPGYAGPNPTSEHLRTDAGFYAAFLTAQGRILHDVFIYRDACDTAHPPGHSWLVEVDAAEADRLQKHIRRYKLRAKFDVRLLDEGEGTVWQAWDDDATSSPAPIPPSETIIISTPDTRAPNLGHRLLTFSPTPLSSLLPIVPEASYHLRRYTYGIPEGQSELIFNQALPHESNADAMHAIDFRKGCYVGQELTIRTEHRGVVRKRILPCLLYPDGQVPLPGDLDLTGAYRPEIEDGVTAEQIPREASIGRAPGGKKGRSAGKWLRGVGNVGLALCRLEIMTDVVLPGEASSGAGGFGEGDEFVVGVERVGEGEEGRKVRIKAFVPEWLRKGLVRGEGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SMM5</accession>
    <name>A0AAN6SMM5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_50127</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854542">
        <property type="protein sequence ID" value="KAK4033254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SMM5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000245">
        <property type="entry name" value="Short chain dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF9">
        <property type="entry name" value="OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4033254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="297" mass="30475" checksum="DAEB2DE8E78F7458" modified="2024-10-02" version="1">MSPSATTPAVADLALPATVPESHQTPAHNASHAALFSLTGKTVAITGGGRGLGITLAGAVLEAGGHVACLDILPSPAADEWAALQKLSSASNLGLSYRRVDVTDEDALAGVFDSIDAEAAAQGAPLYGCVACAGIQQKVPALEYPAADFERIQRVNVTGAFLTAKHAARVLVKNGVRGSLVLIASMSGQIANRGLTCTAYNTSKAAVQQMCRSLAQEWGQHGIRVNTLSPGYIRTAMTDELLAAAPELEQIWMAGALLNRLGAPEDFKAPAVFLLGAGSSFMTGADLRVDGGHCASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SNF1</accession>
    <name>A0AAN6SNF1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_39976</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854522">
        <property type="protein sequence ID" value="KAK4033570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SNF1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042902316" description="Ig-like domain-containing protein" evidence="3">
        <location>
            <begin position="22"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="29"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4033570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="223" mass="23040" checksum="7C74AB0E52E8FB0C" modified="2024-10-02" version="1">MAKQTLLGLCLVAVLATRTAAQASTSTLPVVTLLLDPIEGAVFEASVVTVRPEGTLYSIECRTTATVPEPTNQCSWIQNMSILQGSREFTADWTVINGPDSKTTIANYFDCILDGDNGYCTNTVSENGVVTTFPSIFTSIWERTSPITITAGAEKLSGPAVPSVPASTTSSSPTWASNTTQQTPPVSSAVVTGGGTVLRPADQIAFAVLVAGLGGVVLGGVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SNW9</accession>
    <name>A0AAN6SNW9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">proteasome endopeptidase complex</fullName>
            <ecNumber evidence="3">3.4.25.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">C8A01DRAFT_49390</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.25.1" evidence="3"/>
    <dbReference type="EMBL" id="MU854492">
        <property type="protein sequence ID" value="KAK4034153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SNW9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03763">
        <property type="entry name" value="proteasome_beta_type_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000005">
        <property type="entry name" value="Proteasome subunit beta type-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024689">
        <property type="entry name" value="Proteasome_bsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF4">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12465">
        <property type="entry name" value="Pr_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="8 13" id="KW-0647">Proteasome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0888">Threonine protease</keyword>
    <feature type="domain" description="Proteasome beta subunit C-terminal" evidence="12">
        <location>
            <begin position="221"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR600243-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF12465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK4034153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="272" mass="29289" checksum="60AE528F5BAA08ED" modified="2024-10-02" version="1">MPGFDFSNYNRNAALHARGVPLPKATSTGTTIVGCIYEGGVVIAADTRATSGPIVADKNCEKLHYIAPNIWCAGAGTAADTEFTTALISSQLELHSLSTGRKPRVVTCMTMLKQHLFRYQGHIGAYLVVAGVDPTGTHLFTVHAHGSTDKLPYVTMGSGSLAAMSVFETQWKPSLTQDEAVKLCADAIEAGIWNDLGSGSNVDVAIITGDKTTLRRNYIRPNERTQKLKSYAFPKGTTAVLNEKIIRKAELGNFVSVHELTEESGDKMEVDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SP87</accession>
    <name>A0AAN6SP87_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Actin cortical patch SUR7/pH-response regulator pali</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_48324</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854442">
        <property type="protein sequence ID" value="KAK4038029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SP87"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035838">
        <property type="term" value="C:growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051380">
        <property type="entry name" value="pH-response_reg_palI/RIM9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28013:SF7">
        <property type="entry name" value="PALI-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28013">
        <property type="entry name" value="PROTEIN DCV1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4038029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="228" mass="24104" checksum="A86F96867853DE7C" modified="2024-10-02" version="1">MAGTGFFHHIGTFLLFAATVLLIITCISAPVVHDLSLLKVELGGDNGRGETVTFGTFGFCQTLPDADDACSSSQVGYSPAAVLARADGTQFSDYAERTTRSLTKAMVLHPIASGLNFIAFLLALGAGMVGSFLASLVALLAFLTTAVACIIDFVLFSIVKSNANDRGEVTGSGAYYGAAAWTILVSAVCSLVGAVVVFFTCCSARMHRRRGVPAKTEYASPPRRRRFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SPB3</accession>
    <name>A0AAN6SPB3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">C8A01DRAFT_17763</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type III membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OST4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854439">
        <property type="protein sequence ID" value="KAK4038104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SPB3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018943">
        <property type="entry name" value="Oligosaccaryltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051307">
        <property type="entry name" value="OST4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036330">
        <property type="entry name" value="Ost4p_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48164">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48164:SF1">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10215">
        <property type="entry name" value="Ost4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103464">
        <property type="entry name" value="Oligosaccharyltransferase subunit ost4p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="35"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK4038104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="60" mass="6671" checksum="10D5A007213851AC" modified="2024-10-02" version="1">MITDTELYRLAIVLGSAAMVLIILYHFFEVNSGEEESETLKEKGPRKAAPQTTLASTKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SPB9</accession>
    <name>A0AAN6SPB9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Folic acid synthesis protein FOL1</fullName>
            <ecNumber evidence="10">2.5.1.15</ecNumber>
            <ecNumber evidence="12">2.7.6.3</ecNumber>
            <ecNumber evidence="11">4.1.2.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="24">Folic acid synthesis protein fol1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">C8A01DRAFT_18649</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="21">Catalyzes three sequential steps of tetrahydrofolate biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate = 7,8-dihydropteroate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19949"/>
            <dbReference type="ChEBI" id="CHEBI:17836"/>
            <dbReference type="ChEBI" id="CHEBI:17839"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:72950"/>
            <dbReference type="EC" id="2.5.1.15"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>6-hydroxymethyl-7,8-dihydropterin + ATP = (7,8-dihydropterin-6-yl)methyl diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11412"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:44841"/>
            <dbReference type="ChEBI" id="CHEBI:72950"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>7,8-dihydroneopterin = 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde</text>
            <dbReference type="Rhea" id="RHEA:10540"/>
            <dbReference type="ChEBI" id="CHEBI:17001"/>
            <dbReference type="ChEBI" id="CHEBI:17071"/>
            <dbReference type="ChEBI" id="CHEBI:44841"/>
            <dbReference type="EC" id="4.1.2.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 3/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 4/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the C-terminal section; belongs to the DHPS family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">In the N-terminal section; belongs to the DHNA family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="22">In the central section; belongs to the HPPK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.15" evidence="10"/>
    <dbReference type="EC" id="2.7.6.3" evidence="12"/>
    <dbReference type="EC" id="4.1.2.25" evidence="11"/>
    <dbReference type="EMBL" id="MU854474">
        <property type="protein sequence ID" value="KAK4034575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SPB9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005740">
        <property type="term" value="C:mitochondrial envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003848">
        <property type="term" value="F:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004150">
        <property type="term" value="F:dihydroneopterin aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004156">
        <property type="term" value="F:dihydropteroate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00739">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00483">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.20:FF:000006">
        <property type="entry name" value="Dihydropteroate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.560:FF:000005">
        <property type="entry name" value="Folic acid synthesis protein fol1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.560">
        <property type="entry name" value="7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="entry name" value="Dihydropteroate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045031">
        <property type="entry name" value="DHP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006390">
        <property type="entry name" value="DHP_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000550">
        <property type="entry name" value="Hppk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035907">
        <property type="entry name" value="Hppk_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000489">
        <property type="entry name" value="Pterin-binding_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01496">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01498">
        <property type="entry name" value="folK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20941">
        <property type="entry name" value="FOLATE SYNTHESIS PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20941:SF1">
        <property type="entry name" value="FOLIC ACID SYNTHESIS PROTEIN FOL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01288">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00809">
        <property type="entry name" value="Pterin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55083">
        <property type="entry name" value="6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="Dihydropteroate synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00792">
        <property type="entry name" value="DHPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00793">
        <property type="entry name" value="DHPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00794">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50972">
        <property type="entry name" value="PTERIN_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="19" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="16" id="KW-0418">Kinase</keyword>
    <keyword evidence="18" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pterin-binding" evidence="25">
        <location>
            <begin position="264"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00005051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00009640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00009951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00012458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00013043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00013253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00058009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00061548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00067568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00068111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="KAK4034575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="550" mass="60325" checksum="591FB5A26CADCA9E" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SPM7</accession>
    <name>A0AAN6SPM7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_17861</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854443">
        <property type="protein sequence ID" value="KAK4035444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SPM7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042832494" evidence="1">
        <location>
            <begin position="23"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4035444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="187" mass="21146" checksum="07C59185D1780296" modified="2024-10-02" version="1">MMPQGLLPTILSALLWTQAARADSVDEFVGSARIQVLNITSFWDDGALDSRIGCINAAGMLTLDDCAVFTRFDASPNTLYTKAGNCTFQNPNMPMNTDSIYGQNTPAWWCGERGDWPMYEEWYYTLNGQPYPFVCTGNIRCFFDVKAVVPVAGDALPIWTYFWGSQQMDIEAGHWRVTLLWERVDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SPR8</accession>
    <name>A0AAN6SPR8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Hydrolase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_48229</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854439">
        <property type="protein sequence ID" value="KAK4038107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SPR8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09001">
        <property type="entry name" value="GH43_FsAxh1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041542">
        <property type="entry name" value="GH43_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051795">
        <property type="entry name" value="Glycosyl_Hydrlase_43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812">
        <property type="entry name" value="BETA-XYLOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812:SF15">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G00930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17851">
        <property type="entry name" value="GH43_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043007603" evidence="5">
        <location>
            <begin position="24"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-xylosidase C-terminal Concanavalin A-like" evidence="6">
        <location>
            <begin position="346"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4038107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="546" mass="59963" checksum="46177B4A473037DF" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SQC0</accession>
    <name>A0AAN6SQC0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nuclear rim protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_37840</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854435">
        <property type="protein sequence ID" value="KAK4038256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SQC0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043007">
        <property type="term" value="P:maintenance of rDNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007096">
        <property type="term" value="P:regulation of exit from mitosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018819">
        <property type="entry name" value="Nur1/Mug154"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28293">
        <property type="entry name" value="NUCLEAR RIM PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28293:SF1">
        <property type="entry name" value="NUCLEAR RIM PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10332">
        <property type="entry name" value="DUF2418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="305"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="456"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="312"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="380"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4038256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="507" mass="56773" checksum="B92483A18573D12F" modified="2024-10-02" version="1">MPPRPQRLVRRQPLTERLRAMLNPMDFYLWLSEEIQTFNWDSKTFGTRFGLAANFIFLVARANAGRTRDAVDDVFGDAPANGWFTLLANFLQWTLISISALNAFYTMTRSRHYRLFEMNVEAAGPGTPSAQRVRVDSPPASSTPLRLIQEVLRPETAEQRAHPDRTRDVWEMKVWDPYPATLRMFCLFSPGHVLIHMLFLPLPMLDPRPSVTVFKCFLLQVILSAQLLLMHSRFSQQSKDTAIIQKEVMHEYDVKYVHPRLHPVVREVSTQVSINDGKIDQEEITIGTPATVVQRSFQTHPNPNYARYVNPDGNQPAQTRTTMSPQLRSAMPSNPFTPSAKPRASVPPSFAAQVQQQRHSALRKSLPPTGAGGGGPPSTPSTISKTTSTGTSTSTNFNLPPNSGYGGSLGVYTHMNSPLKKATSLGDMNGVYQSPRNNREMAALEQRDLAERMVRQSSPLKEHRRATMAAAQLDQGQGGGSYVHSPEKLARARAGRWTQERFPSRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SQK8</accession>
    <name>A0AAN6SQK8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_47479</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854414">
        <property type="protein sequence ID" value="KAK4038962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SQK8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055496">
        <property type="entry name" value="DUF7068"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46312">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46312:SF2">
        <property type="entry name" value="NUCLEOTIDE-BINDING OLIGOMERIZATION DOMAIN-CONTAINING PROTEIN 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23238">
        <property type="entry name" value="DUF7068"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05729">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NACHT" evidence="1">
        <location>
            <begin position="429"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4038962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1128" mass="126892" checksum="212B573F66A62D20" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SRU0</accession>
    <name>A0AAN6SRU0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 18">Postreplication repair E3 ubiquitin-protein ligase RAD18</fullName>
            <ecNumber evidence="5 18">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">RING-type E3 ubiquitin transferase RAD18</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">C8A01DRAFT_45976</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">E3 RING-finger protein, member of the UBC2/RAD6 epistasis group. Associates to the E2 ubiquitin conjugating enzyme UBC2/RAD6 to form the UBC2-RAD18 ubiquitin ligase complex involved in postreplicative repair (PRR) of damaged DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 18">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="18">Interacts with E2 UBC2, forming a complex with ubiquitin ligase activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 18">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 18">Belongs to the RAD18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5 18"/>
    <dbReference type="EMBL" id="MU854370">
        <property type="protein sequence ID" value="KAK4040774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SRU0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097505">
        <property type="term" value="C:Rad6-Rad18 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006301">
        <property type="term" value="P:DNA damage tolerance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23148">
        <property type="entry name" value="RING-HC_ScRAD18-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000172">
        <property type="entry name" value="E3 ubiquitin-protein ligase RAD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039577">
        <property type="entry name" value="Rad18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004580">
        <property type="entry name" value="Rad18_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006642">
        <property type="entry name" value="Rad18_UBZ4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00599">
        <property type="entry name" value="rad18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14134">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RAD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14134:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RAD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00734">
        <property type="entry name" value="ZnF_Rad18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51908">
        <property type="entry name" value="ZF_UBZ4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 17 18" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14 17 18" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13 18" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15 18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="11 18" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="12 18" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 16 18" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="20">
        <location>
            <begin position="28"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="UBZ4-type" evidence="22">
        <location>
            <begin position="171"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="SAP" evidence="21">
        <location>
            <begin position="239"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="99"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="190"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="303"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="351"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="829"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="148"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="195"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="355"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU368093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KAK4040774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="859" mass="93418" checksum="A25FC1E9C695BF54" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2025-10-08" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SS16</accession>
    <name>A0AAN6SS16_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">JmjC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_15637</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854376">
        <property type="protein sequence ID" value="KAK4040477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017956">
        <property type="entry name" value="AT_hook_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018866">
        <property type="entry name" value="Znf-4CXXC_R1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10497">
        <property type="entry name" value="zf-4CXXC_R1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00929">
        <property type="entry name" value="ATHOOK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00384">
        <property type="entry name" value="AT_hook"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="JmjC" evidence="6">
        <location>
            <begin position="142"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="548"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="750"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="858"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="984"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1024"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1112"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1158"/>
            <end position="1425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="555"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="927"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="993"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1067"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1203"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1219"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1291"/>
            <end position="1301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1302"/>
            <end position="1317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="1356"/>
            <end position="1372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1378"/>
            <end position="1388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1395"/>
            <end position="1407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1408"/>
            <end position="1425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4040477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1425" mass="157743" checksum="A20D468B83B1E59A" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SS24</accession>
    <name>A0AAN6SS24_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">cystathionine gamma-synthase</fullName>
            <ecNumber evidence="10">2.5.1.48</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">O-succinylhomoserine (thiol)-lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">C8A01DRAFT_45756</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of L-cystathionine from O-succinyl-L-homoserine (OSHS) and L-cysteine, via a gamma-replacement reaction. In the absence of thiol, catalyzes gamma-elimination to form 2-oxobutanoate, succinate and ammonia.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-succinyl-L-homoserine + L-cysteine = L,L-cystathionine + succinate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20397"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57661"/>
            <dbReference type="ChEBI" id="CHEBI:58161"/>
            <dbReference type="EC" id="2.5.1.48"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-cystathionine from O-succinyl-L-homoserine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the trans-sulfuration enzymes family. MET7 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.48" evidence="10"/>
    <dbReference type="EMBL" id="MU854365">
        <property type="protein sequence ID" value="KAK4041029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SS24"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003962">
        <property type="term" value="F:cystathionine gamma-synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000111">
        <property type="entry name" value="Cystathionine gamma-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000063">
        <property type="entry name" value="Probable cystathionine gamma-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051750">
        <property type="entry name" value="Trans-sulfuration_enzymes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42699">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42699:SF1">
        <property type="entry name" value="CYSTATHIONINE GAMMA-SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="168"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="207"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00051441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00058439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00060510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00066530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00083849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK4041029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="607" mass="66780" checksum="89090A32F486BBFA" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SS77</accession>
    <name>A0AAN6SS77_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_46281</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854378">
        <property type="protein sequence ID" value="KAK4040385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SS77"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="7"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4040385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="352" mass="38286" checksum="8B8306CE630E5123" modified="2024-10-02" version="1">MASQRLVLITGINGYIAAHTAATFLKAGYAVRGTIRARTPNVESLVRTLDKYHDGTRLELVEVPDISADGTFDRAVEGVQAVAHLASPVSMTETDPAPMMRAAVQGTTSLFASALAESRRESRRDTLKSVVFMSTISAIFTPSKPAGHIFTEADWNDAAEEEVRRLGKSTPGYVIYQASKTAAERAFWAFGKEAGAEFGMTALCPAPVLGPSLYLPEPISSLSMRVKDIYDIFHGGAIPEFSPIRSTFVDVRDVAELVLRAVERDTKTPRARERYLLVGQSPISPQGVADVLRASFPERRDTIREGNPGETYPDMAWRFDAGKAGTLLGRDWIGFERSVVDSAKVFLGAEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SSF3</accession>
    <name>A0AAN6SSF3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Scd6-like Sm domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_35657</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854379">
        <property type="protein sequence ID" value="KAK4040328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SSF3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033962">
        <property type="term" value="P:P-body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034063">
        <property type="term" value="P:stress granule assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01736">
        <property type="entry name" value="LSm14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025762">
        <property type="entry name" value="DFDF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019050">
        <property type="entry name" value="FDF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025761">
        <property type="entry name" value="FFD_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025609">
        <property type="entry name" value="Lsm14-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025768">
        <property type="entry name" value="TFG_box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13586">
        <property type="entry name" value="SCD6 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13586:SF0">
        <property type="entry name" value="TRAILER HITCH, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09532">
        <property type="entry name" value="FDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12701">
        <property type="entry name" value="LSM14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01199">
        <property type="entry name" value="FDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01271">
        <property type="entry name" value="LSM14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51512">
        <property type="entry name" value="DFDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51513">
        <property type="entry name" value="FFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51536">
        <property type="entry name" value="TFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sm" evidence="7">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="DFDF" evidence="4">
        <location>
            <begin position="435"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="FFD box profile" evidence="5">
        <location>
            <begin position="494"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="TFG box profile" evidence="6">
        <location>
            <begin position="521"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="80"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="192"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="386"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="473"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="506"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="FFD box" evidence="1">
        <location>
            <begin position="494"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="TFG box" evidence="2">
        <location>
            <begin position="521"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="124"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="228"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="392"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="473"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="550"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4040328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="585" mass="60076" checksum="DFCF0D43DABFB278" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SSM4</accession>
    <name>A0AAN6SSM4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF899 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_35192</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854369">
        <property type="protein sequence ID" value="KAK4040820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SSM4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010296">
        <property type="entry name" value="DUF899_thioredox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05988">
        <property type="entry name" value="DUF899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4040820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="239" mass="26863" checksum="795FED4C2D781E0D" modified="2024-10-02" version="1">MATKVVTREEWFAARKALLEKEKEITRAQDAVAAQLRELPMVEVDKRYRFHGPDGSTLLLEDLFGGKDQLIVYHFMFGPDAERGCKGCAFVGEHIPNLRHLGSRNTAFVAVSRGPFAKLDAWKKTVGWTFPWYSSEGSDFNYDFHATLDPAVLPVEYNFATAAELEAKGLKYNTAGEQPGLSVFVRRDGKVYHTYSAYSRGVERLLGTFHLLDMTPLGRQVGPAGPADFKLKYEYEEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SSP8</accession>
    <name>A0AAN6SSP8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fatty acid hydroxylase superfamily-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_45813</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854367">
        <property type="protein sequence ID" value="KAK4040880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SSP8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="7">
        <location>
            <begin position="203"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="354"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="367"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4040880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="385" mass="43240" checksum="9CA811C99D18957A" modified="2024-10-02" version="1">MANTTVASGLPPLPAYEIRPMPDLLPFISDFWLSLVVTHVAYWILSMFFHIIDVYDLFPQYRLHTPDEIAQRNLASRYEVARDVVVQQVIQTGMSAFLSATDPRQTTGMEDYDVAVWATRIRLAQRALPAVLGTLGLNATAISKNMATSYPLLAGALAGGHYPFLTTTLDDVTGTAVPAFATWELLVAKAIYWVIIPGFQLWLATCFLDTWQYFWHRAMHMNKWMYTNWHSRHHRLYVPYAYGALYNHPVEGFVLDTLGAGVAYKAAMLSPRGGLVFFVFSTIKTVDDHCGYALPWDPLQHITSNNAAYHDIHHQSWGIKTNFSQPFFTIWDRVLGTMWRGDTALKYERTRTAAAGKSVKKGETEKAAVNGNKVNGKANGKAKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SSW1</accession>
    <name>A0AAN6SSW1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_45814</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854367">
        <property type="protein sequence ID" value="KAK4040881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SSW1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40625:SF1">
        <property type="entry name" value="AMP-ACTIVATED PROTEIN KINASE GLYCOGEN-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40625">
        <property type="entry name" value="GTP-BINDING PROTEIN ESDC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="395"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4040881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="441" mass="48231" checksum="325AFC4AB69F3061" modified="2024-10-02" version="1">MDPTTTLFTFMLRRDRGQWKGCYNFKDITCEGDAGSIPKRDGGLKMGHTYYYYYELDGASETHDSSQPSTNTCPYLPGQTLNTLWIPVEQSGRKRSASLTSLHEADFKTMDPSSKFVAPRPAPTPPEPARRLGTAPLRMQQKRPSRSPSPSSRWHFSARKLFSRKSSSSSLRDMQTPQAEDERSLQSEGSRSRDISPESLRRFLVDDVPLDHEEDANRPVIDIPEDIAEEMEDDDNFATSAVSETMQFTGLSPPPPRALSPAMSIASMNDTAAPPSLYRTIPAAPTRPPPLLPILQTAPPARPDLSFPLSALYPESPDSNSPPGFYLDDADDDIDDEEEEDDAANDEEDEDALGVQQQKKNPFARNIAATLSTYSLPRTAGTEGGKLGAAASPGQQQQQQQQQQVQGAGGPLMLTSPIPDAGLGELVSELGWMAGIIGGRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6STA2</accession>
    <name>A0AAN6STA2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_34435</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854356">
        <property type="protein sequence ID" value="KAK4041480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6STA2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="22"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4041480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="111" mass="12383" checksum="B4696FD63079A636" modified="2024-10-02" version="1">MKAPDATALQAHIRNAHLPNPLVCAECGRQSLTPRALNRHLRRHRDPNKHRCVFCNQGFHRQDELGNHVVGQHNAALQQVVAFAVSHNHPAVVNQPAQEENVDPALYQAVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6STK7</accession>
    <name>A0AAN6STK7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">choline-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="9">2.7.7.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">CTP:phosphocholine cytidylyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Phosphorylcholine transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">C8A01DRAFT_33298</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytidylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.15" evidence="9"/>
    <dbReference type="EMBL" id="MU854338">
        <property type="protein sequence ID" value="KAK4042634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6STK7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004105">
        <property type="term" value="F:choline-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031210">
        <property type="term" value="F:phosphatidylcholine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02174">
        <property type="entry name" value="CCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000147">
        <property type="entry name" value="Cholinephosphate cytidylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041723">
        <property type="entry name" value="CCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045049">
        <property type="entry name" value="Pcy1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10739:SF13">
        <property type="entry name" value="CHOLINE-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10739">
        <property type="entry name" value="CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="13">
        <location>
            <begin position="176"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="368"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="466"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="18"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="405"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="435"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="472"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00076205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00080967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK4042634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="512" mass="55117" checksum="B498AE7B01F27661" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6STP0</accession>
    <name>A0AAN6STP0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pal1 cell morphology protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_45181</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854352">
        <property type="protein sequence ID" value="KAK4041751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6STP0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013226">
        <property type="entry name" value="Pal1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28307">
        <property type="entry name" value="PROTEIN PAL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28307:SF2">
        <property type="entry name" value="PROTEIN PAL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08316">
        <property type="entry name" value="Pal1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="418"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="456"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4041751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="524" mass="57503" checksum="3AED9C8741ED3C76" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SU65</accession>
    <name>A0AAN6SU65_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 10">Chitin synthase</fullName>
            <ecNumber evidence="2 10">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">C8A01DRAFT_44317</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cell membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the chitin synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2 10"/>
    <dbReference type="EMBL" id="MU854337">
        <property type="protein sequence ID" value="KAK4042697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SU65"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013616">
        <property type="entry name" value="Chitin_synth_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF9">
        <property type="entry name" value="CHITIN SYNTHASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01644">
        <property type="entry name" value="Chitin_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08407">
        <property type="entry name" value="Chitin_synth_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="4 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="529"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="560"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="604"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="635"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="682"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="811"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="854"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase N-terminal" evidence="12">
        <location>
            <begin position="145"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="88"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="749"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK4042697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="887" mass="100663" checksum="A9EFA483999C3EC5" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SVC2</accession>
    <name>A0AAN6SVC2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Death-receptor fusion protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_43125</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the THADA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854322">
        <property type="protein sequence ID" value="KAK4043957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056843">
        <property type="entry name" value="THADA-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056842">
        <property type="entry name" value="THADA-like_TPR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019442">
        <property type="entry name" value="THADA/TRM732_DUF2428"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051954">
        <property type="entry name" value="tRNA_methyltransferase_THADA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14387:SF0">
        <property type="entry name" value="DUF2428 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14387">
        <property type="entry name" value="THADA/DEATH RECEPTOR INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10350">
        <property type="entry name" value="DUF2428"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25150">
        <property type="entry name" value="TPR_Trm732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25151">
        <property type="entry name" value="TPR_Trm732_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26523">
        <property type="entry name" value="Trm732_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA (32-2'-O)-methyltransferase regulator THADA-like TPR repeats region" evidence="6">
        <location>
            <begin position="174"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2428" evidence="5">
        <location>
            <begin position="597"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA (32-2'-O)-methyltransferase regulator THADA-like C-terminal TPR repeats region" evidence="7">
        <location>
            <begin position="840"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="537"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4043957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1492" mass="163780" checksum="C047C88F2899CEE9" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SVJ2</accession>
    <name>A0AAN6SVJ2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_43081</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854321">
        <property type="protein sequence ID" value="KAK4044167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SVJ2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF68">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01120)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="308"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="402"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="436"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="463"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="534"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="579"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="619"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="646"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="680"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="713"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="310"/>
            <end position="742"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4044167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="750" mass="81473" checksum="180A236E43F8F76C" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SVR8</accession>
    <name>A0AAN6SVR8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_12673</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854323">
        <property type="protein sequence ID" value="KAK4043941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SVR8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="185"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4043941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="314" mass="33758" checksum="83A1303E2266FB4D" modified="2024-10-02" version="1">MCTGIIGQCDCERCLKQPLPETIQRVEFCKKKQKELTGITGGRLSHTDLRYLHVPCEKLILFITADRDRCRFKNEAEKENLTPAHTPIRFTPINAEAVAKAALSVMAKDKADVAQGVTAIAGNDKNMMDIDVPSRAAGENEIGKMRKMDKDENNMGNAGSINKADKVDVDTPSTVTAGPAAGTSTNPPIITTTVKPITNTNTSASTGTSTGTSTGTIIHLARTTPATNGRTPLPSSRPRTPRVLQATAAAAAAQAAERVASGEWTHEETVRLLLLRCKEVEFGEMGQYLPGRDVEACVNRLEGLAVKHGYEAYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2025-10-08" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SW73</accession>
    <name>A0AAN6SW73_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Proteasome component ECM29</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_31414</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854319">
        <property type="protein sequence ID" value="KAK4044361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024372">
        <property type="entry name" value="Ecm29_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055443">
        <property type="entry name" value="HEAT_ECM29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23346:SF19">
        <property type="entry name" value="PROTEASOME ADAPTER AND SCAFFOLD PROTEIN ECM29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23346">
        <property type="entry name" value="TRANSLATIONAL ACTIVATOR GCN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23731">
        <property type="entry name" value="ARM_ECM29_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13001">
        <property type="entry name" value="ECM29_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24492">
        <property type="entry name" value="HEAT_ECM29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Proteasome component Ecm29 N-terminal" evidence="6">
        <location>
            <begin position="14"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="Proteasome adapter and scaffold protein ECM29 HEAT-repeat" evidence="7">
        <location>
            <begin position="1295"/>
            <end position="1455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1675"/>
            <end position="1695"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF24492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4044361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1876" mass="206346" checksum="90B0C660FD06CA93" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SWJ1</accession>
    <name>A0AAN6SWJ1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Kynureninase</fullName>
            <ecNumber evidence="4 5">3.7.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Biosynthesis of nicotinic acid protein 5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">L-kynurenine hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BNA5</name>
        <name evidence="7" type="ORF">C8A01DRAFT_11892</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25143"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36559"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:58125"/>
            <dbReference type="EC" id="3.7.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 5">
            <text>L-kynurenine + H2O = anthranilate + L-alanine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16813"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:57959"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="3.7.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 5">Amino-acid degradation; L-kynurenine degradation; L-alanine and anthranilate from L-kynurenine: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 5">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the kynureninase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.7.1.3" evidence="4 5"/>
    <dbReference type="EMBL" id="MU854317">
        <property type="protein sequence ID" value="KAK4044706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SWJ1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030429">
        <property type="term" value="F:kynureninase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043420">
        <property type="term" value="P:anthranilate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097053">
        <property type="term" value="P:L-kynurenine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019805">
        <property type="term" value="P:quinolinate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000031">
        <property type="entry name" value="Kynureninase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01970">
        <property type="entry name" value="Kynureninase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010111">
        <property type="entry name" value="Kynureninase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01814">
        <property type="entry name" value="kynureninase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14084">
        <property type="entry name" value="KYNURENINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14084:SF0">
        <property type="entry name" value="KYNURENINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22580">
        <property type="entry name" value="KYNU_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038800">
        <property type="entry name" value="KYNU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 4 5" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="3 4 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="6">
        <location>
            <begin position="75"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="168"/>
            <end position="171"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="350"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR038800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4044706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="482" mass="52457" checksum="17363E4E2F7639BA" modified="2024-10-02" version="1">MSSHSNAAAAIAAARERARALDRDDPLAFTRSEFNIPTKAQIASTRLPDSATAETGSGDGATDKCVYLCGNSLGLQPKRTQTRISQYLSTWATQGVQGHFKPLDESPLPTWLDADERAAQLIAPIVGASEAEVAVMQTLTANLHLLMSAFYQPDINGKHKIMLESKAFPSDHFAVETQLRHHNLDPATSMITLTSPSSPEDNILTTAEILSSIDAHAATTALLLLPGIQYYTGQLLDIPTITAHARRHSIFVIWDLAHAVGNVSLRLHDWNVDAAAWCSYKYLNSGPGCIGGMFVHERNSAVTRAITEDRPEEGYTNRLAGWWGNEKGTRFVMANKFHPVKGAAGFQLSNPSILDITSLSASLEVFAEAGGVGALRDKSVRLTGFLEELLSSGVGEEERGLFRVITPRDAEQRGAQLSLMLKGGLLETVMRELERRGVIVDERRPDVIRVAPAPLYNTFEDCVGFVEAFAEALAVARRERGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P4D7</accession>
    <name>A0AAN6P4D7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Heterokaryon incompatibility protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_51420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854773">
        <property type="protein sequence ID" value="KAK4031533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P4D7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26639">
        <property type="entry name" value="Het-6_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042913923" evidence="1">
        <location>
            <begin position="29"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="30"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4031533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="605" mass="68194" checksum="87E6B91E311E8550" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P4X4</accession>
    <name>A0AAN6P4X4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ubiquinol-cytochrome-c reductase complex subunit-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_41728</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854694">
        <property type="protein sequence ID" value="KAK4031834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P4X4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019182">
        <property type="entry name" value="Cytochrome_b-c1_su10_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28254">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28254:SF1">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09796">
        <property type="entry name" value="QCR10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4031834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="92" mass="10295" checksum="6336A02CCAAE2DFB" modified="2024-10-02" version="1">MPFPTPSRRAPAFPEYKSPYGPKYYYQSHVAGITQKTLLRTGVKAGMFGGVALFAVIFYASGIPRIQIDILQKIPFLGQRFVKETHASDNPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P5V1</accession>
    <name>A0AAN6P5V1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Putative gamma-glutamylcyclotransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_42195</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the gamma-glutamylcyclotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854856">
        <property type="protein sequence ID" value="KAK4031342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P5V1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045038">
        <property type="entry name" value="AIG2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009288">
        <property type="entry name" value="AIG2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036568">
        <property type="entry name" value="GGCT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31544">
        <property type="entry name" value="AIG2-LIKE PROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31544:SF4">
        <property type="entry name" value="GAMMA-GLUTAMYLCYCLOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06094">
        <property type="entry name" value="GGACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110857">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Gamma-glutamylcyclotransferase AIG2-like" evidence="5">
        <location>
            <begin position="22"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4031342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="180" mass="20333" checksum="57279EF5950D893D" modified="2024-10-02" version="1">MPANSALERSEPQPYVHTPVYYFFYGTLTEPKMLQDVLGLATEPVLRDAKTHGYALAHWGQYKALIDGEPGATVTGRAYMVQSAEEEHKLAHYETTAYKLAPCNMYFTDGPDGKEDEEPTVGKTFRYAGDGQALRDGRFDRTLWEWQMGKRLPPAWDGGARHQLRQGGFEETGMDPDKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P5X8</accession>
    <name>A0AAN6P5X8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_50893</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.67" evidence="1"/>
    <dbReference type="EMBL" id="MU854627">
        <property type="protein sequence ID" value="KAK4032289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P5X8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042995">
        <property type="term" value="C:cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016314">
        <property type="term" value="F:phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043491">
        <property type="term" value="P:phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051896">
        <property type="term" value="P:regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14497">
        <property type="entry name" value="PTP_PTEN-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051281">
        <property type="entry name" value="Dual-spec_lipid-protein_phosph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029023">
        <property type="entry name" value="Tensin_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005344">
        <property type="entry name" value="TMEM33/Pom33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12305">
        <property type="entry name" value="PHOSPHATASE WITH HOMOLOGY TO TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12305:SF81">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03661">
        <property type="entry name" value="TMEM33_Pom33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51181">
        <property type="entry name" value="PPASE_TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatase tensin-type" evidence="6">
        <location>
            <begin position="272"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="5">
        <location>
            <begin position="365"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="528"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="593"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="738"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="613"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="769"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="788"/>
            <end position="798"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4032289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="851" mass="92118" checksum="43CF85FBA28B9388" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P690</accession>
    <name>A0AAN6P690_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="24">Sulfite reductase [NADPH] flavoprotein component-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">C8A01DRAFT_50691</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="22">This enzyme catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(S)-3-hydroxybutanoate + 2-oxoglutarate = (R)-2-hydroxyglutarate + acetoacetate</text>
            <dbReference type="Rhea" id="RHEA:23048"/>
            <dbReference type="ChEBI" id="CHEBI:11047"/>
            <dbReference type="ChEBI" id="CHEBI:13705"/>
            <dbReference type="ChEBI" id="CHEBI:15801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="EC" id="1.1.99.24"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>4-hydroxybutanoate + 2-oxoglutarate = (R)-2-hydroxyglutarate + succinate semialdehyde</text>
            <dbReference type="Rhea" id="RHEA:24734"/>
            <dbReference type="ChEBI" id="CHEBI:15801"/>
            <dbReference type="ChEBI" id="CHEBI:16724"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="EC" id="1.1.99.24"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>hydrogen sulfide + 3 NADP(+) + 3 H2O = sulfite + 3 NADPH + 4 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13801"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Sulfur metabolism; hydrogen sulfide biosynthesis; hydrogen sulfide from sulfite (NADPH route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the iron-containing alcohol dehydrogenase family. Hydroxyacid-oxoacid transhydrogenase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854598">
        <property type="protein sequence ID" value="KAK4032538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047988">
        <property type="term" value="F:hydroxyacid-oxoacid transhydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016903">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004783">
        <property type="term" value="F:sulfite reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06207">
        <property type="entry name" value="CyPoR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08190">
        <property type="entry name" value="HOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1970:FF:000009">
        <property type="entry name" value="Fe-containing alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1090.10:FF:000003">
        <property type="entry name" value="Probable hydroxyacid-oxoacid transhydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000007">
        <property type="entry name" value="Pyruvate:ferredoxin (Flavodoxin) oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.990.10:FF:000010">
        <property type="entry name" value="Sulfite reductase [NADPH] flavoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000052">
        <property type="entry name" value="Sulfite reductase [NADPH] flavoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000011">
        <property type="entry name" value="Sulfite reductase flavoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1090.10">
        <property type="entry name" value="Dehydroquinate synthase-like - alpha domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.920.10">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF17147">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56796">
        <property type="entry name" value="Dehydroquinate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53323">
        <property type="entry name" value="Pyruvate-ferredoxin oxidoreductase, PFOR, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="15" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12" id="KW-0274">FAD</keyword>
    <keyword evidence="9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0288">FMN</keyword>
    <keyword evidence="17" id="KW-0408">Iron</keyword>
    <keyword evidence="18" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-0521">NADP</keyword>
    <keyword evidence="16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="23">
        <location>
            <begin position="660"/>
            <end position="891"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010005"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022946"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00049496"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00052219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00059320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KAK4032538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1495" mass="162749" checksum="FC167A90C4381C19" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P6L1</accession>
    <name>A0AAN6P6L1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_20350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAK4032575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P6L1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043025473" evidence="1">
        <location>
            <begin position="18"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4032575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="212" mass="23187" checksum="5A7A09CCBD5DB57B" modified="2024-10-02" version="1">MKFTTLLTLCATAAAQAAQTDYFFRFAGGNAIINGQRLRGNNSISYYSPGVTRPPYNPDDHFMRLSTNASACSPAAVLTVVPTHPHPPPVPGYYGLSDKEGVPDAYRLVYTYRVAEDYGAGFRYTEWQLRRTGEAGRVLLRYPVAGGGEWKWIAVREMSGGAGDVEKWVPWYVKRSAANAAKLAEWDFESVDLELVQAKGGVNSQAPGGVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P6M2</accession>
    <name>A0AAN6P6M2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Imidazoleglycerol-phosphate dehydratase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_20238</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854580">
        <property type="protein sequence ID" value="KAK4032734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P6M2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038882">
        <property type="entry name" value="Rcf3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39153">
        <property type="entry name" value="AGR244WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39153:SF1">
        <property type="entry name" value="AGR244WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4032734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="109" mass="12261" checksum="486EB45398F15162" modified="2024-10-02" version="1">MPSANDAKHVEATEASWEASRGAVTGALKWGLATAVLGGIGYAVSPVYRGLTIQFKVYLQMSGMVLGSMIEADSRLRQYEARVRVQRRVARDQAYWERFEREYGKDEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P6S3</accession>
    <name>A0AAN6P6S3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_50503</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854575">
        <property type="protein sequence ID" value="KAK4032793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P6S3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF3">
        <property type="entry name" value="HALOTOLERANCE PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="52"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="123"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="617"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="775"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="11"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="160"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="176"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="631"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="795"/>
            <end position="805"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4032793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="805" mass="87607" checksum="36043B7B7A31E24A" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P6X6</accession>
    <name>A0AAN6P6X6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ndc10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_50436</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854568">
        <property type="protein sequence ID" value="KAK4032868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P6X6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.20">
        <property type="entry name" value="Centromere DNA-binding protein complex CBF3 subunit, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038279">
        <property type="entry name" value="Ndc10_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031872">
        <property type="entry name" value="NDC10_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022210">
        <property type="entry name" value="TF_GCR1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12550">
        <property type="entry name" value="GCR1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16787">
        <property type="entry name" value="NDC10_II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ndc10" evidence="3">
        <location>
            <begin position="274"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="Ndc10" evidence="3">
        <location>
            <begin position="519"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription activator GCR1-like" evidence="2">
        <location>
            <begin position="727"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4032868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="795" mass="89554" checksum="7698E72F9A46783E" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P775</accession>
    <name>A0AAN6P775_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kinetochore complex Sim4 subunit Fta1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_21168</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854736">
        <property type="protein sequence ID" value="KAK4031658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P775"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025204">
        <property type="entry name" value="CENP-L"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13092">
        <property type="entry name" value="CENP-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4031658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="471" mass="51239" checksum="B38FF8E5A1247F55" modified="2024-10-02" version="1">MPPKRRQPRPPDPEPEPPRPASPPPDRDGDQSPSEEEDDSIAEHSPLPFYNTTFSAHRVSPLYLGAESLTTNRLQILAQRLRDRLVGDVVRGVEVGVQAADREDSMIGRAGALERVEIAWVGLADVLGFSGEDVENSEAEDVEDGDGTTGWRQAVRAGELREKRALHISLRYEMASCTALMLPALLGDGKKSGVEGATTRFSVGGGADEMDWEHSVDPTHFLSLPLLLLRMPAPLKTIIGEFLSTTFDCRVSPMRLGTRSLVRSWEAWIRSAGLPSRGPLAKDMVLTLGFYISPSDPVPTQPSEEDAAAEQQQPLGLKSIDVIIPATELGKFATAGKRVAKTQGKQTASPTGWGWDNDPKKRRKLAGRLYEEGWEWRTASPEGRPPEHQPFTEALACYLKEHLGLNLFHPSVRVIKIACGGFAMSESRLKLFAPAGSGDAEGEGLPLLAQRGAVLELLGRLADKAQITVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P7I1</accession>
    <name>A0AAN6P7I1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Manganese/iron superoxide dismutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_40416</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854550">
        <property type="protein sequence ID" value="KAK4033129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P7I1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.40.20">
        <property type="entry name" value="Iron/manganese superoxide dismutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019832">
        <property type="entry name" value="Mn/Fe_SOD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036324">
        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43595">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN S26, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43595:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02777">
        <property type="entry name" value="Sod_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54719">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46609">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Manganese/iron superoxide dismutase C-terminal" evidence="3">
        <location>
            <begin position="132"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4033129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="324" mass="35198" checksum="76F8317AC0D916AF" modified="2024-10-02" version="1">MLRPRLRIPLRPRASTPATTTLLPLACRARAMHALAPLEYNLKNEASQNGIADFLSPAAFNIAWTQYQTHLLEKLNGMIAETDYEARHVKDILLKSARNPEDAPIFNHASMTHNNHFFFKHLSPKPVAMPDALRGHLERSFGSIETLRQEMVYTAAAMFGPGFVWLVKTSQPGLPVAFKVLATYAAGSPYPGAHWRRQGVDMTTAAGANTDAGIDAGKAYLDQTAYGAGKRTPGSGGGPGTGASSVAKKVEHAPGGTDLLPVLCLNTWEHVWLWDYGFGVGAPDRGKLGFAEKWWKHVNWDLVLKEANVQKLEMSANMGASAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P804</accession>
    <name>A0AAN6P804_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_19640</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854532">
        <property type="protein sequence ID" value="KAK4033414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P804"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053178">
        <property type="entry name" value="Osmoadaptation_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111:SF2">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G01560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="14"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="350"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="353"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4033414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="491" mass="54133" checksum="842B86DA94D8CA39" modified="2024-10-02" version="1">MFLGPFDRRKQRHRCDACTKSHLKCSGDSPCTTCVRRNQPCCYSVAAQKKSAILVDRGKQQTVGTYAVLRQDRVPQAPTQSIKSPSVSDPTFLYFFYYDIFLQKNKFTGLAAPQNDVKQLARQGDAETYLRDAMLALGAMQASKLCQVPKSKKTYYQSALESYTRAIAGLRRALSQFDRTHDPQPRAGILWTTLLLGLFELMHDSTGDGWLQHLVHGTAQALIAGGPSTCISGSCRRFFTESKVFEVCREIVFNRPTFLAEERWMALSASLRASSAWSRSLQALDALLDIVVMCSSLRVQAANLIDSLQSSTAAAPDIAHHAQAISTQGFALRAQLHDWASANHTSPAFQLSEEQRQDPPADDNKPNPDPAPQLLSETFFSATSIYLSGVFDYEITHWQTLNLLPLPTLSEDAIQQHVASILALSQRLVGETSLSPLLLLFPLRVASARARQAGQRRQIMELLGVVRASFAVAGAIVGDVEELWGRGGMVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P8U0</accession>
    <name>A0AAN6P8U0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_39734</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854509">
        <property type="protein sequence ID" value="KAK4033805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P8U0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4033805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="323" mass="35755" checksum="6689322749D0DE7A" modified="2024-10-02" version="1">MFKNRLMEKVRAAADPPKTEAVIPAEIQPLYLLMWEHGIKRHFDGSSSDWSEPIPGHLTTRPGKRPGLRASAKRVTFTGDVLREIFDPTVNKIARLVREQVEGVWQDCEELPKSAIVCGGFSGNPYLQNKTREQVDQLNEEHGKDHANMRFEVAPEWLSRQLVATDCAMRASEQDPQSLNLPAQRTTRVASRIARASYAIHSSSTISPHQFITKGEGLLVTQPKVIHLAPVHFNVRPGIAASLTIYRGQETTINRDRMVKDCEISWTGAAFGRLSEAVVGGLPVQLSVGWSNNAVGFEVSVNGTVQTPGMLDGFCMDYAMHDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P8Y0</accession>
    <name>A0AAN6P8Y0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_39603</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854502">
        <property type="protein sequence ID" value="KAK4033946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P8Y0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052184">
        <property type="entry name" value="SDR_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458:SF3">
        <property type="entry name" value="CHAIN DEHYDROGENASE (ATSC), PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE SDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4033946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="273" mass="30052" checksum="0B923B73B19CD138" modified="2024-10-02" version="1">MPSYVITGVSGFLGFEFLRQISEDQSNTVVGLVRDKVATDKKVSEQLGGRCNVHILQADMTDYDSVQKAVADTAKISGGSVDYLIANAAYVPQWDLYDPIDVLANKPQELEEEMLKSFKVNVVGNVHLFHLFMPLILKGQVKKVVAISSGTADLEPMRQFDMTLSSAYVISKAAMNAAVGKFSAQYRKEGVLFISICPGMVEPEASHYANATPEQLKALEEFLARFKQYAPHYTGPARREDAVRDVIGVWEKASIENGDAGAFVSHLGNKQWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P8Z2</accession>
    <name>A0AAN6P8Z2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">3-hydroxyacyl-CoA dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_20374</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854597">
        <property type="protein sequence ID" value="KAK4032543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P8Z2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48075:SF3">
        <property type="entry name" value="3-HYDROXYACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48075">
        <property type="entry name" value="3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase NAD binding" evidence="4">
        <location>
            <begin position="93"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase C-terminal" evidence="3">
        <location>
            <begin position="291"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="61"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="70"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4032543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="413" mass="45309" checksum="5EB4F582451FC14F" modified="2024-10-02" version="1">MNSSRRLALRSIPTISRAAISGASRPICTPVSRLGVLACWGTCQTPFTPYRHLPAIQHSPFTTSPYRSDGAGKEAHPPKWRPPTDESLKQRPVLVVGAGNIGRRVALVWASDTRPVTIYDISPDALHSATEYITDNLAAYCTARGTHPGHVCTTTDLRTATTTSGHPERDSAGTITPQEHTKAPWLAIECLPESLPLKTSVLALLERSLPSDCILASNSSSLTTAEMAAEGPLTHPHRLLNTHYFIPPRNRMVELMSSGATAGAVFPFLAGQMRRVGFAPVTVPRDIQSRGFVFNRIWAACKRETLAVLAEGVAQPGDVDALFRDFFHAEKGPCERMDEVGLDTVVRVEQHNLERRPGLGSEAALKWLRENYVELGKLGEKSGDGLFTGEERDRLREKHHLERYRDVEETSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P9L3</accession>
    <name>A0AAN6P9L3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Histone deacetylase</fullName>
            <ecNumber evidence="2 9">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">C8A01DRAFT_39252</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>N(6)-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetate</text>
            <dbReference type="Rhea" id="RHEA:58196"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="3.5.1.98"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the histone deacetylase family. HD Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="2 9"/>
    <dbReference type="EMBL" id="MU854486">
        <property type="protein sequence ID" value="KAK4034284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P9L3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034967">
        <property type="term" value="C:Set3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000007">
        <property type="entry name" value="Histone deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003084">
        <property type="entry name" value="HDAC_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF36">
        <property type="entry name" value="HISTONE DEACETYLASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037913">
        <property type="entry name" value="His_deacetylse_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01271">
        <property type="entry name" value="HISDACETLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="14">
        <location>
            <begin position="83"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="473"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="473"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="368"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR037913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK4034284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="496" mass="55910" checksum="AD8875F50781873A" modified="2024-10-02" version="1">MDAAAYRYRPPKPNYLPHNIEADDPVVEEYALPLGKADDRENAIFFNKMKFAAQEYGIVRPKGYTVSYHATPEMEKHHFGQTHPMKPWRLTLTKSLVTAYGMPFAMDNYVTREATYEELNAFHSSDYLDYLSTAAPEDQPRDIENPDKEVKYNLGGSDCPLFHGLYNYCSMSAGCSLDAARKISSNQSDIAIAWGGGLHHAKRYEASGFCYINDIVLAILQLLRTFPRVLYIDIDVHHGDGVEEAFFSTDRVMTVSFHKYHPETFFPGTGALEDNGPKSENNPGAHHAINVPLQDGITDEQYEALFESIIGTINERYRPSAIALQCGADSLAGDRLGRFNLRVQGHGACVRYCKSLGLPMIVFGGGGYTPRNVARAWAYETSIAIGADTRIPETIPDHAPWREHFIHDTLFPTLEQSMNEPRHNRNSDKRLREIVAHVHEQLRFVSHAPSVQSMIIPPDLGPIRDDVEARLKEENEERNGGLRRIHEEGLGQDMEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P9T2</accession>
    <name>A0AAN6P9T2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Yos1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_19593</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the YOS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854529">
        <property type="protein sequence ID" value="KAK4033457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P9T2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013880">
        <property type="entry name" value="Yos1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15858">
        <property type="entry name" value="IMMEDIATE EARLY RESPONSE 3-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15858:SF0">
        <property type="entry name" value="IMMEDIATE EARLY RESPONSE 3-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08571">
        <property type="entry name" value="Yos1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043017047" evidence="9">
        <location>
            <begin position="18"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4033457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="83" mass="9271" checksum="D721FE8D5305F749" modified="2024-10-02" version="1">MTLLGKFIYVTILLLNAICIPSEDRFLARVGLAPATYQRGFGQEADSSVKYKMIQLIASVRTVMRVPLIIINTLIIVYELILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PA30</accession>
    <name>A0AAN6PA30_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_18657</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854475">
        <property type="protein sequence ID" value="KAK4034546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PA30"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4034546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="439" mass="48121" checksum="9287622914FFB01A" modified="2024-10-02" version="1">MELAGPGFASLPPELLATICTFLCSHCEREHNGQPWPFEADPDHQNYGSAQAGVQTPAQRLGSRSDSANLSSLSRVCRSLHAAAEPFLYHCPATSGQSDLWLLAKTLINRPDLASRVLELDLGYPTLDASILLTAMLLHLAPSLQRAHFCLPSDSAFNTLLAELAWSCPPLLSLKALAFSVLDTIFRPTKLSGAAPILRLAPHLRALHLDSCSSVTKHLGVFLGRDANTQPPSLHITELSLSHASLDFESLRFLLRETGPRLSRVSIRRTGTLRARGDWGHRLEFNDVLNNLNGSQQTLKNLSFTSSKEVLFTPARPRLDISTLHNFQALEILRTDAVFFTSHGETKPDNNPFTATIPSSLQELHLGGYYVNLGPDLRVLLAAFQVGHYAALRKIEIDAGVAEEYDPESEAAQQLREVAASFRSAGVDFVVHGDEHQHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PAF6</accession>
    <name>A0AAN6PAF6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_18553</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854469">
        <property type="protein sequence ID" value="KAK4034690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PAF6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4034690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="229" mass="25916" checksum="DFC6B9171017882E" modified="2024-10-02" version="1" fragment="single">ASIQTTVPDIINWPVQKRKMWQGKGNLPPWIEVRRIAGKAIDNGLQTHTLEELVDIVKQPCKEAGIKAARNKRDKDAQLKREYHNMVMSLLHGRSRSKVVPPRTVDIAELTGRIESLQAEAARQKKKKDQGYVEVEAPDRSAREIPQHTGFYASLFKGFFNPPTLQMPSPGSKRGLFRMATNGGADRLPKAGKEPDDMPVEETHYDDLNEWVNVEKDLDSEWEPVAAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PB40</accession>
    <name>A0AAN6PB40_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_18153</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854454">
        <property type="protein sequence ID" value="KAK4035116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PB40"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="2"/>
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    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
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    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002204">
        <property type="entry name" value="3-OH-isobutyrate_DH-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="HIBADH-like_NADP-bd"/>
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    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007728">
        <property type="entry name" value="Pre-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43060">
        <property type="entry name" value="3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43060:SF17">
        <property type="entry name" value="L-THREONATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00468">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="3_HYDROXYISOBUT_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pre-SET" evidence="7">
        <location>
            <begin position="530"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="6">
        <location>
            <begin position="620"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="8">
        <location>
            <begin position="773"/>
            <end position="789"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4035116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="789" mass="85292" checksum="A6EEDF4EB406CE7C" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PBB8</accession>
    <name>A0AAN6PBB8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1996 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_38302</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854451">
        <property type="protein sequence ID" value="KAK4035208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PBB8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018535">
        <property type="entry name" value="DUF1996"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662:SF13">
        <property type="entry name" value="DUF1996 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09362">
        <property type="entry name" value="DUF1996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042978946" description="DUF1996 domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1996" evidence="2">
        <location>
            <begin position="32"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4035208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="339" mass="37793" checksum="04BE11953B7B2F6C" modified="2024-10-02" version="1">MHMKSLTALALAAPASALLRFGCSQLVVERLDPLVNPGLNPSPHLHQIIGGNAFNLTMNAESGDIAQKATCTTCQFSEDFSNYWTAVLFFKARNGTYHRVPQIPNVGFEGQTGGMTVYYMQDGLANYEQTSKVTAFKTGFRMLVGEASYRNKEQANRFRQITYTCLKEMGTRFPETMHFPTEPCPVGIMANVRFPTCWDGKNLDSPDHMSHMSYPETGTFESGGPCPASHPVRVPQLMYETIWDTSKFNDKELWPEDGSQPFVWSMDDTTGFGSHGDYMFGWKDDSLQRAMDSPCYVNCPTLKTQSVSEMNKCSVPNTVDEDFDGWLKALPGAHTGMKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PBH2</accession>
    <name>A0AAN6PBH2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="3">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_48437</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="MU854447">
        <property type="protein sequence ID" value="KAK4035341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PBH2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07106">
        <property type="entry name" value="ALDH_AldA-AAD23400"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000009">
        <property type="entry name" value="Aldehyde dehydrogenase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000007">
        <property type="entry name" value="NAD/NADP-dependent betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044086">
        <property type="entry name" value="LUC3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="7">
        <location>
            <begin position="25"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4035341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="481" mass="53153" checksum="E2ACE23A710647BE" modified="2024-10-02" version="1">MASKIDITTYPGNIINGEFAPTPTTRHSIDPATGEPLYEVPVARKEDLDAAVNHARAAFKSWSKTTHEERAKLLTAFADVVEANRDELEKLQTMEQGKPLSLAHTEVDMTLQWLRTFATMQLPDEVLEDTEDRTVYSTRVPLGVVGAIVPWNWPILLGLGKVGPALMTGNTVIMKPSPYTPYCDLKLGELAMSVFPPGVFQVLSGDDNLGPWVTEHPGINMISFTGSIATGKRVAASCARTLKRYVLELGGNDAAIVCDDVDIDKCLPKIAMMAFLNSGQICMLCKRIYVHEKIYHKFRDAMVEFTKNHIKTGGGFEPDVVVGPLQNSMQFEIVRNMYAQISKSGWEVALEGKVRETAKGYFIEPAIIDNPPEDSRIVVEEPFGPIVPLLKWSSEEDVIDRANALETGLGASVWSKDVARAEKMARQINAGSVWVNSHFDTAPNVSFGGHKESGVGVEWGIEGFKHFTNSRSVWVWKKVFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PBZ8</accession>
    <name>A0AAN6PBZ8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_48225</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854439">
        <property type="protein sequence ID" value="KAK4038103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PBZ8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032378">
        <property type="entry name" value="ZC3H15/TMA46_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12681:SF0">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12681">
        <property type="entry name" value="ZINC FINGER-CONTAINING PROTEIN P48ZNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16543">
        <property type="entry name" value="DFRP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="91"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="166"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="91"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="166"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="276"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="292"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="307"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4038103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="357" mass="40406" checksum="A6E83B06D01F8455" modified="2024-10-02" version="1">MPPKKADKGGKKPDAKKIVEDKTFGMKNKKGGAAKKTIAQLEASSLATQKRKEAEKQAREREKKAAEEAKRETDALLGKPAQVQKVPFGVDPKTVVCIFYKKGNCEKGKKCKFAHDLEVERKTEKRNLYTDSRAEEEETKKQETSADWDEEKLRSVVLSKKGNQRTTTDKVCKFFIQAIEDGKYGWFWICPNGGDKCMYKHALPPGFVLKTKEQRAAEKALLDKSPLKTLTIEEFLESERHKLTGTLTPVTPDSFAKWKKERLDKKAAEEQLRKAKEATGRALFESGNWRMDDEESEDEDDSAWNLERLRQETEALRNKKEEERLAMQGITLPSGEPSGEPDGVPEEAAEPETVPNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PCH7</accession>
    <name>A0AAN6PCH7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">Arabinan endo-1,5-alpha-L-arabinosidase</fullName>
            <ecNumber evidence="4 7">3.2.1.99</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">C8A01DRAFT_18321</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>Endohydrolysis of (1-&gt;5)-alpha-arabinofuranosidic linkages in (1-&gt;5)-arabinans.</text>
            <dbReference type="EC" id="3.2.1.99"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Glycan metabolism; L-arabinan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.99" evidence="4 7"/>
    <dbReference type="EMBL" id="MU854460">
        <property type="protein sequence ID" value="KAK4034955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PCH7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046558">
        <property type="term" value="F:arabinan endo-1,5-alpha-L-arabinosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18831">
        <property type="entry name" value="GH43_AnAbnA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050727">
        <property type="entry name" value="GH43_arabinanases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016840">
        <property type="entry name" value="Glyco_hydro_43_endo_a_Ara-ase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43301">
        <property type="entry name" value="ARABINAN ENDO-1,5-ALPHA-L-ARABINOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43301:SF3">
        <property type="entry name" value="ARABINAN ENDO-1,5-ALPHA-L-ARABINOSIDASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026534">
        <property type="entry name" value="Endo_alpha-L-arabinosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042846613" description="Arabinan endo-1,5-alpha-L-arabinosidase" evidence="10">
        <location>
            <begin position="23"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="36"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="9">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR026534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK4034955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="321" mass="34315" checksum="F7D0769E28AA0D16" modified="2024-10-02" version="1">MVKISDLLGAVALLPILVSAYALPEACSGVCNNSHDPSIIRRTDGTYFRFSTGGRIAIHTAPSLTGPWTYVGAALPSGSSINLAGNQDLWAPDVAQVGSQYYLYYSVSTFGVQDSAIGIASSSSLDAGTWTDLGSTGVASSEGSAYNAIDGNLVNEAGTRNYFLTFGSFWNGIYRVRVTPTQTNGDAYQVAFDPNDTAMEGPTVFKYGDFYYLFFSKGSCCGYDKDMPAAGEEYRIMVCRSSSPVGPFVDSAGTSCRSGGGTVVLASHDWVYGPGGQGVYQDPTYGPVLYYHYVDTRIGYEDGQKQLGWNKIDFSSGWPVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PCZ3</accession>
    <name>A0AAN6PCZ3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AA1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_48540</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854451">
        <property type="protein sequence ID" value="KAK4035210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PCZ3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032382">
        <property type="entry name" value="AltA1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16541">
        <property type="entry name" value="AltA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042811645" description="AA1-like domain-containing protein" evidence="5">
        <location>
            <begin position="20"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="AA1-like" evidence="6">
        <location>
            <begin position="51"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4035210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="196" mass="21715" checksum="351B8A1579910F2D" modified="2024-10-02" version="1">MHFRTAFAAVPLLALTATASPVPSPKPEVDARSPAGCSAASFKNFAWTAKNFDFHASYIFTTPAHQNSWGYVSFDLVNPADQTTTHCEGQSNQLSDFFYGTVPYKCNDTERLGATSFDFARPTNQLRLNQTWTCDDQDPQWPSTFTGRGNANLTLDCTDETWKNPDWEMGQIYSSRTITCAPVESTFKPTELSAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PD43</accession>
    <name>A0AAN6PD43_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_17213</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854420">
        <property type="protein sequence ID" value="KAK4038754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PD43"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF261">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G00590)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="8">
        <location>
            <begin position="17"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="414"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="415"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4038754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="436" mass="48200" checksum="6438E4BB29DF2FAD" modified="2024-10-02" version="1">MDLDLPNTEDAQPRPLSILIIGGGIGGLSAAISLRQNGHHVMDKSNLSSDSGAALHLCPNASGILHRWGINAQNFGPSFMSRYIERAQDGRTLKDVDLAESNARWPYPWQMVHRASFHQELKRVAASGEGGGVPVALLPKHRVIDVDPQLGATLEDGKLVPADVILGADGIYSRTRQVIKTLPLFRTGKAAFRFVLPKSMAESDPTTAPLIIPKDTFTLWFADDRRVVMYPCHNNEWLNFVCIHPDTESRTAPTDEWNKESSLDQVLHVFRDFDPQLLALFTKANAATIKVWQLLDMDTLPTWTSGKFALMGDAAHPCLPYQAQGGAQAIEDAAALAAVLPLGTTPAEVPERLKLYETIRSKRAFRIQEYSRLTGQDWVDGQPVVGMREFEEYNFDHDEIANATAAFKEWMMAKQQQTPAATPPIAAEPSTGLERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PD76</accession>
    <name>A0AAN6PD76_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">WSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_38277</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854450">
        <property type="protein sequence ID" value="KAK4035257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PD76"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051589">
        <property type="entry name" value="Sialate-O-sulfotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45964">
        <property type="entry name" value="WSCD FAMILY MEMBER CG9164"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45964:SF5">
        <property type="entry name" value="WSCD FAMILY MEMBER CG9164"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042830175" description="WSC domain-containing protein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="5">
        <location>
            <begin position="38"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="4">
        <location>
            <begin position="121"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="89"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4035257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="259" mass="28209" checksum="8223F8D56676C445" modified="2024-10-02" version="1">MKLSVLFSLVALARQASSSVSPTPLLQWDPDTAKDCVEWYNNGDGESCEYVRKLFGITPEQFTKWNPSVGLDCKPWDWQSYCIVTQERLDNTPPPPMTTSSSTTTATSTTSSSTLGPSPTAWVDRGCYVEDPSLPILEQNMSPAGGDASLTIPKCKDSCYRRAYEFAGVQEGNQCWCGTYVGGEWARNQTDCNIPCTGDNKTFCGGKGLLSIFQAQENQEEPVYSIGTSTSTGSNPDTVVTTVSETRSSSGAMRNMAWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PDB2</accession>
    <name>A0AAN6PDB2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribokinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_17174</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854419">
        <property type="protein sequence ID" value="KAK4038793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PDB2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052562">
        <property type="entry name" value="Ketohexokinase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42774:SF3">
        <property type="entry name" value="KETOHEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42774">
        <property type="entry name" value="PHOSPHOTRANSFERASE SYSTEM TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="3">
        <location>
            <begin position="199"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4038793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="322" mass="33582" checksum="A5D72BA14819280E" modified="2024-10-02" version="1">MKHLILVGACYLDTILTVPHFPAEDSKLRATALHVRRGGNCPNSLEVLAQLVLSGAGGPQIKLHLVSCLPDAGAAATRKILSSFGGGDGNDVSGNGGGADIVDCSHCLYRAGHEAPASSYIIRSGATGSRTIVNFSDLPEVTADEFEGIADVFAAAAAAAEQHGDDGGWWHFEGRIPETTLRCIRYLRRVTPGCTISVEVEKPNREGLVELAAEADVVFYSRSWAEPRAHNCGSLSQGRSGVIQEGGAGALALPGGEYIHHAAAPSGDGIAVVDTIGAGDTFIAAMLYGLHADAWSLEARLEFGVTLATKKVQREGFAGLVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PDI2</accession>
    <name>A0AAN6PDI2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_47552</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854416">
        <property type="protein sequence ID" value="KAK4038913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PDI2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4038913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="146" mass="14720" checksum="49226CA19C111A6E" modified="2024-10-02" version="1">MKALTTAVALLFPDDETDTTTTTPIPSLPTAPACAAVTATRELCTTCVIPACLAVSTITQSCGCPTPVPTVHLDFPCASGCDGLWCSTSYAIVTAAGCVTDGPSPTTESTTTTFAPNGTVTTASPTSSSSIATNAAGRLRAPFILW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PDM8</accession>
    <name>A0AAN6PDM8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_39447</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854496">
        <property type="protein sequence ID" value="KAK4034067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PDM8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4034067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="200" mass="21509" checksum="87EC1B8BB3E88150" modified="2024-10-02" version="1">MPQNGVMEIPNDDESDKSDKFSLGSLWKQSWHEYKCSYEQLKSKSSTGTGTNVATAHATSGGSRLSQPLRAGRLHCGDVGGTKMPPKDVIVISSDDESSDSETYDNESYDDASDDDESSDDGSSNDGSSDDGSSDDESSDEQQKSGPGCPLAQDRHLLLITPHATTPLQRRLLLPLLDTRPHALITDVDAIPSSSRSYAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PDP6</accession>
    <name>A0AAN6PDP6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="28">Tubulin alpha chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="28" type="ORF">C8A01DRAFT_48200</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="29" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="29">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="21">Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization.</text>
    </comment>
    <comment type="function">
        <text evidence="22">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the PAN1 actin cytoskeleton-regulatory complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
            <orientation evidence="4">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
            <location evidence="3">Actin patch</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the tubulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="28">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854438">
        <property type="protein sequence ID" value="KAK4038143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1650" mass="176171" checksum="B7BEB70256CF87BF" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PDS7</accession>
    <name>A0AAN6PDS7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_47707</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854420">
        <property type="protein sequence ID" value="KAK4038757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4038757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="270" mass="29436" checksum="1C526824C428251A" modified="2024-10-02" version="1">MNHPSEEFPVNLVCSSLRQRPAWSSTATQLLQSDGRRWREAHLGTHDIALTIPDPHTEENHDTFRLLLLSPEDLTNPRTLPRIQHLHRLSNGRNTALLFFLESQNGAQPAMQPFMDLHITLHSHNCPMPIIPLASSSAETDNSHASPAAAGRALQTFRSSLVASRGAARRRWPVDTAGDLLPYCTTTATTTTTNNNNETGSSSSSSTSVPAAGLSRRAVEVLSGRWFSFGELLRDGVATEEGRREVREAVGDAEGEGVVAFWGFEFATAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PEB9</accession>
    <name>A0AAN6PEB9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF962 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_48605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854453">
        <property type="protein sequence ID" value="KAK4035168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PEB9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046521">
        <property type="term" value="P:sphingoid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009305">
        <property type="entry name" value="Mpo1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28026:SF9">
        <property type="entry name" value="2-HYDROXY-PALMITIC ACID DIOXYGENASE MPO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28026">
        <property type="entry name" value="DUF962 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G05310)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06127">
        <property type="entry name" value="Mpo1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4035168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="195" mass="21795" checksum="CEFFB83800F1AFEE" modified="2024-10-02" version="1">MSLDLEKQLTFYGAYHHNQVNVIIHVVCVPLILFSFFELASNYGPFFTLPPWLQIPYLEPNLGTFAAMTWGGLYLLLEPVAGGVLAVICLAAAAGTNYLRLQDTAGTNQISIAVHLVSWIAQFVGHGKFEGRAPALLDNLFQAVFLAPLFVWLELLFMVGYRPELKRRVDKAVEVEIAKFREQKAKKAEKAEKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PEI6</accession>
    <name>A0AAN6PEI6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GmrSD restriction endonucleases C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_47067</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854399">
        <property type="protein sequence ID" value="KAK4039504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PEI6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011089">
        <property type="entry name" value="GmrSD_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24094:SF15">
        <property type="entry name" value="AMP-DEPENDENT SYNTHETASE_LIGASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24094">
        <property type="entry name" value="SECRETED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07510">
        <property type="entry name" value="GmrSD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042966596" description="GmrSD restriction endonucleases C-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="GmrSD restriction endonucleases C-terminal" evidence="2">
        <location>
            <begin position="103"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4039504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="204" mass="21873" checksum="1214F6EC1811EF06" modified="2024-10-02" version="1">MKSFILGSLLAAAVSAVPMPAPSPPGIPSATTAKSQLAALTVKAAYDDGGYSRDLFPHWETASGSCNTREYVLKRDGTNVVVDSACTATSGTWFSPYDGATWTAASDVDIDHMVPLKNAWVSGANTWSTARRTQFANDIDIPQLWAVTDNVNQGKGDKSPDAWKPPLSSFYCTYSKSWVYVKHSYGLSITSAEKSALTSMLNTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PEK7</accession>
    <name>A0AAN6PEK7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">C8A01DRAFT_47022</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854398">
        <property type="protein sequence ID" value="KAK4039534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19079">
        <property type="entry name" value="AKR_EcYajO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001530">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000913">
        <property type="entry name" value="ABC multidrug transporter SitT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000004">
        <property type="entry name" value="Oxidoreductase, aldo/keto reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF27">
        <property type="entry name" value="ATP-DEPENDENT TRANSLOCASE ABCB1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="640"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="683"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="762"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="788"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="867"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="1"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="309"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="644"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="968"/>
            <end position="1201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK4039534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1560" mass="172655" checksum="C71DFE5F709007CF" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PFM5</accession>
    <name>A0AAN6PFM5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1479 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_46516</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854384">
        <property type="protein sequence ID" value="KAK4040119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PFM5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010856">
        <property type="entry name" value="Gig2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30613:SF1">
        <property type="entry name" value="DUF1479 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G09280)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30613">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN YBIU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07350">
        <property type="entry name" value="Gig2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4040119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="498" mass="54511" checksum="F81AB79770D0C334" modified="2024-10-02" version="1">MAAMNAAGKAEGDISDTFASLSGRKAQPLPDRFRELKLRLVAGHEDAVIASWKRLLATLREENDLIARTGHAIVPEVRFSHLHDDLEALKPEIKKRGVAVIRGVIPEDEARAYKFEIEEYARQNPQTRGFPPTSPQVLELYWSPSQLRARSHRNLLTTQRALMTSLWHTTTTPNPSSTTPISLHTPLTYADRLRIRQPGDAHFALGPHQDAGSVERWEEGGYGGAPGKGRGGGGGGGVYGSVFRGTWETEYDAYDASSGRVEAVTDLYSGLGACSMFRMFQGWLAISRSGPLQGTLLVNPLVREAGVYSLLRPFFRARRELNEVGGDKGRYLDEGNWVFTTGEEMTSEIQGAMPGCAQEFSEGAHPHLELERTMVHVPEVRPGDYVVWHCDSIHAVDKKHNGTADSSVLYIPVCPTTKASAEYMVRQRAAFRQGTPGPDFPGGEGESRHIGRGTEEYVRKYCDPAGIQAMGLDKLATAEGDTPGGKAVVAEANRILGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PFX4</accession>
    <name>A0AAN6PFX4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">C8A01DRAFT_36027</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854387">
        <property type="protein sequence ID" value="KAK4039977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PFX4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052215">
        <property type="entry name" value="Plant_ABCG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48042">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48042:SF11">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="376"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="410"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="454"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="489"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="517"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="618"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="39"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK4039977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="640" mass="70385" checksum="D736B6B296698F72" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PG77</accession>
    <name>A0AAN6PG77_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ClpP/crotonase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_17309</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854423">
        <property type="protein sequence ID" value="KAK4038656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PG77"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051053">
        <property type="entry name" value="ECH/Chromodomain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684:SF4">
        <property type="entry name" value="ENOYL-COA HYDRATASE_ISOMERASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G01890)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4038656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="311" mass="33530" checksum="BCC8C78DA4778F7A" modified="2024-10-02" version="1">MSTVTVPPSYSSLPFQDISVSHVPADSPTASKVLIVAFNRPDKYNAVTENLLTELETAYRMIDQDERVRAVVLTGTGKAFCAGADLQIGFSGLLANKESEESIAKYRDQGGRVALAMTNCTKPTIVALNGPAAGFGFTITFPAAIRVAWSDAKVGLPFARRGLTLESCSAFFLPRLLGLAKATHLATTGATYAASDPLVSPLFSKLLPTPQETVAYAVELATDIAENTSPTSTKLMRDLLLYSPGSPEEMHELDSKVFISMVGSKDNMEGIKSFMKKKKPEFSGSFDRESVPFWPWWAHAPRGNGDAIAKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PGN0</accession>
    <name>A0AAN6PGN0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">UTP15 C terminal-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_35708</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854380">
        <property type="protein sequence ID" value="KAK4040287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PGN0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001577">
        <property type="entry name" value="WGS project CABT00000000 data, contig 2.26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018983">
        <property type="entry name" value="U3_snoRNA-assocProt_15_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19924:SF26">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19924">
        <property type="entry name" value="UTP15 U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 15 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09384">
        <property type="entry name" value="UTP15_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="138"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="181"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="266"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 15 C-terminal" evidence="7">
        <location>
            <begin position="395"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4040287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="552" mass="59765" checksum="DCD3951D72E6041A" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PGN2</accession>
    <name>A0AAN6PGN2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_47821</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="MU854424">
        <property type="protein sequence ID" value="KAK4038624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PGN2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="4">
        <location>
            <begin position="20"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4038624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="177" mass="19717" checksum="06E8C7A70EA63F54" modified="2024-10-02" version="1">MADQPRSEVIKQKPIGNGLEAGLLHRDISIANLMVSKDNGGFLIDLDLAVKEQRVSASGAKGKTRTRAFMAIGALLGEQHSFMHDLDSFFWVLFWICIHCDGPGEGTVVAQFDKWTYADTEELAQLKKGEISDEGDFIKAAEKNFTPRWEREDSGLYTQMRGLLNEARKDPRVSAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PGQ4</accession>
    <name>A0AAN6PGQ4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_47550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854416">
        <property type="protein sequence ID" value="KAK4038911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PGQ4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38166:SF1">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38166">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="467"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="483"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4038911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="734" mass="78302" checksum="6B6D8A002A1795BA" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PGQ6</accession>
    <name>A0AAN6PGQ6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_46113</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854374">
        <property type="protein sequence ID" value="KAK4040556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PGQ6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4040556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="153" mass="17410" checksum="280485CCAA01B0B3" modified="2024-10-02" version="1">MDPFSIPIEPIRAPHYEIDPSLRTITRGSHDFPTDTDLRYIGYQYDWDRPFPFWHFLGRMVAKAVFDDTADLKQLNFVAMGRQEFIVYTSSSWRAAAAAQKAAGVIEVNFKKPQPGQPIEMTWAPARALFTDKIGECRSTNLTPPPPVGWKAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PGY0</accession>
    <name>A0AAN6PGY0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Inner centromere protein ARK-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_35244</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the INCENP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854370">
        <property type="protein sequence ID" value="KAK4040773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22249">
        <property type="entry name" value="UDM1_RNF168_RNF169-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005635">
        <property type="entry name" value="Inner_centromere_prot_ARK-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13142">
        <property type="entry name" value="INNER CENTROMERE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13142:SF1">
        <property type="entry name" value="INNER CENTROMERE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03941">
        <property type="entry name" value="INCENP_ARK-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inner centromere protein ARK-binding" evidence="9">
        <location>
            <begin position="1251"/>
            <end position="1304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="69"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="125"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="655"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="697"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1319"/>
            <end position="1359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="69"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="141"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="171"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="214"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="227"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="252"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="290"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="310"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="384"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="407"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="432"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="464"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="510"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="538"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="697"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="718"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="795"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="832"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="901"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="949"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="969"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1114"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1183"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1253"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1328"/>
            <end position="1359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4040773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1359" mass="148234" checksum="03C1044131367DC4" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PGZ3</accession>
    <name>A0AAN6PGZ3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Feruloyl esterase C</fullName>
            <ecNumber evidence="11">3.1.1.73</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Ferulic acid esterase C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">C8A01DRAFT_16242</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 11">Involved in degradation of plant cell walls. Hydrolyzes the feruloyl-arabinose ester bond in arabinoxylans, and the feruloyl-galactose ester bond in pectin. Active against paranitrophenyl-acetate, methyl ferulate and wheat arabinoxylan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>feruloyl-polysaccharide + H2O = ferulate + polysaccharide.</text>
            <dbReference type="EC" id="3.1.1.73"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the faeC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.73" evidence="11"/>
    <dbReference type="EMBL" id="MU854391">
        <property type="protein sequence ID" value="KAK4039825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PGZ3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030600">
        <property type="term" value="F:feruloyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043595">
        <property type="entry name" value="FaeB/C/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38050:SF1">
        <property type="entry name" value="FERULOYL ESTERASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <keyword evidence="4 11" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042669231" description="Feruloyl esterase C" evidence="11">
        <location>
            <begin position="21"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="13">
        <location>
            <begin position="301"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="268"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="270"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK4039825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="337" mass="34727" checksum="40BB5B442516F391" modified="2024-10-02" version="1">MISIPTLALALLSALQAVDAASAGCGKAPPSSGTKSMTVNGKQRQYILQLPANYDRNKAHRVVIGYHWRDGSMNDVANGGFYGLRSLAGDSTIFVAPNGLNAGWANNGGEDITFTDQIVAMLENDLCVDEGQFFATGWSYGGSMSHSVACSRPNVFKAVSVIAGAQLSGCSGGSTPVAYLGIHGAADNVLPISLGRQLRDKWLQTNGCASKNAPEPSAGQQSDIKTVYSCSRAPVTWIGHGGGHVPDPSGTNGVKFAPGETWSFFNAAVSGGSNPGTTSSASTAPATTTSPGTQPTNPGANCSPRYSQCGGQGWTGPTCCQSGSTCQLSNNWYSQCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PGZ9</accession>
    <name>A0AAN6PGZ9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome c oxidase subunit 13, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Cytochrome c oxidase polypeptide VIa</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">C8A01DRAFT_35266</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the cytochrome c oxidase subunit 6A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854371">
        <property type="protein sequence ID" value="KAK4040706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PGZ9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.95.10:FF:000001">
        <property type="entry name" value="Cytochrome c oxidase subunit 6A, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.95.10">
        <property type="entry name" value="Cytochrome c oxidase, subunit VIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001349">
        <property type="entry name" value="Cyt_c_oxidase_su6a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036418">
        <property type="entry name" value="Cyt_c_oxidase_su6a_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11504">
        <property type="entry name" value="CYTOCHROME C OXIDASE POLYPEPTIDE VIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11504:SF0">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02046">
        <property type="entry name" value="COX6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000277">
        <property type="entry name" value="COX6A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81411">
        <property type="entry name" value="Mitochondrial cytochrome c oxidase subunit VIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00070930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00082360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK4040706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="129" mass="15468" checksum="3695EC9B9AAC1866" modified="2024-10-02" version="1">MFAQRQIARAAQRFSAQARAQAQRRFASHEAENHFVRERRHVKEHASATTELWRKISLYGIPPTLLLAGVNAYMLWNEHWEHWSHMPPLEERVEYPYQNMRTKNFQWGDGDKTLFWNDSVNYHNKDKTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PH73</accession>
    <name>A0AAN6PH73_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MYB transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_17021</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854415">
        <property type="protein sequence ID" value="KAK4038924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PH73"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050560">
        <property type="entry name" value="MYB_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45614">
        <property type="entry name" value="MYB PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45614:SF51">
        <property type="entry name" value="MYB-LIKE DNA-BINDING PROTEIN BAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH myb-type" evidence="3">
        <location>
            <begin position="8"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="8"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="396"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4038924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="433" mass="45906" checksum="F4643EAE98E9EFEF" modified="2024-10-02" version="1">MPSHTSESPAKKQSKWSPEEDALIIELRGSGMKWDDISKRLPGRSSISCRLHYQNYLERRSEWDEERKNKLARLYERFKPEMWAKVAEEMQVPWRAAEAMHWQLGEIEMARRAGVVPFSLNMTSNEPQGPMMQRISPTRGHAHSQSQGSVPRDFSGLPSPRYTRGPPGPGPPPPQIPPMIPPPTPTSAGSGGGGVSRPLSSRRESLTRGPPFGPPLSELTADYGYGLAPIQTTALSGSHSHSHGRPSSEARHNSISGGMLLPSVAELTTGVSPYNTPAYTLGGPQQQQHSVTSPIHSSATASPGPGSGGAPGSSGGGGALLPALSPYPQPPPSLEPTAGKRRASPPDHHLGSRRETSRRRQHLYPSSTRGGGGGTATTGRDEYPPTPPPPPPPSHPSQQQQQQLPFGMGMGGALGMTGPSAVAPARRGAGHGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PHG2</accession>
    <name>A0AAN6PHG2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_36756</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the ustYa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854405">
        <property type="protein sequence ID" value="KAK4039271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PHG2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF4">
        <property type="entry name" value="CYCLOCHLOROTINE BIOSYNTHESIS PROTEIN O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0843">Virulence</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4039271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="234" mass="27041" checksum="C5497AA8D5189E00" modified="2024-10-02" version="1">MDIRDFMPTNSKPSYDRLADVLDDEEAEALAVLVLMVLGWAFYQNTLPPEPTYEFMVPSNVPMEYQTVRFNATVPGTRDTEWLGPSNDKTDALWDSLLDVGVIALDAAQISHLSPPPARLANGQDGWAGTFEVFHQIHCLNLLRKRFFAPERNGPADWGEEADLWEWHNEHCFEYLRQTLLCHADVNIFPLEYDARHEVYVPRPSAEKRCRNWDVVHDYAREHMATDTRREAHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PHN3</accession>
    <name>A0AAN6PHN3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_15883</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854382">
        <property type="protein sequence ID" value="KAK4040200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PHN3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="144"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4040200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="160" mass="17248" checksum="FD275B04D0A02591" modified="2024-10-02" version="1">MCIWSYSHHHHLPPCTQPIEMVVNYQYCDFASTDPVTGVTQPCEQAFFGDDAALMNQVDYNDPCATGGCLLSPDCESGGCRLAQLGGRWACCQCGGRANEHRWCQHRMRTSPDTFCYHTCCDGCRADYAAPPHSHSANGGGSSTAGSSSGSSSSGRRGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PHZ3</accession>
    <name>A0AAN6PHZ3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_45719</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854364">
        <property type="protein sequence ID" value="KAK4041087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PHZ3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4041087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="457" mass="50862" checksum="1E05EEE4F7CAD122" modified="2024-10-02" version="1">MVDKDTLRTIVSGYCPLLPRLCTLPSELLEMIRHHSRHGLLWRCIPALQLAAHVSATKPEPLLTVSLRELLSWECGGKLERVTASQSPLTTLRLSVDSVDISKVERLPGPLPYAGECTSRAAFIVQDEASILGVTAQLKDRRLRLRFHAGAQPMLPIWNTHAPPSLTLCKASPPVLASCQALYAVEMDRVKGITFFFSNGLLFGIHGHRSEESCAADTFTRLHNFLRRSIVWIYLPISECDRALVLGIREALQTRDLSIFVRTERIGDVIIGLQCGGNDDAKNQCLAVSAPVTMIYGEPKEGRAVRFFGAHCRRALDQPLLEPFRLAKPGPSPIDKYAYFSCAPLRGVSSTLVFYDQSTGFCRGIVLRYDNGGSRAVGQCRLQVDPAERVARPARLCFRADSSSPRRPNRKIYTVQVKFKQSSPTNDSDIEGWESRPMDGLVKFWFTHESSVLVVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PI79</accession>
    <name>A0AAN6PI79_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_36592</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854400">
        <property type="protein sequence ID" value="KAK4039464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PI79"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4039464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="153" mass="16002" checksum="94F543A90899A19A" modified="2024-10-02" version="1">MSPPAPTETTESGSGSGVAAPAGAAKAAVVVPVAESPAATTTMAGPVAEAQEGEGKGREGRADVKKSWVEELRKAVEAEGKEGNSAIADSDEESDIEAPAAPIHRRQGHQARSDQRRHQAPEEDEEEKARYASMESAIAFLREHGVDAKDFAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PJ07</accession>
    <name>A0AAN6PJ07_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glucan 1,3-beta-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_14507</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854351">
        <property type="protein sequence ID" value="KAK4041771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PJ07"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23668">
        <property type="entry name" value="GH55_beta13glucanase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000049">
        <property type="entry name" value="Putative exo-beta-1,3-glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039279">
        <property type="entry name" value="QRT3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024535">
        <property type="entry name" value="RHGA/B-epi-like_pectate_lyase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33928:SF2">
        <property type="entry name" value="PECTATE LYASE SUPERFAMILY PROTEIN DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33928">
        <property type="entry name" value="POLYGALACTURONASE QRT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12708">
        <property type="entry name" value="Pect-lyase_RHGA_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042929235" evidence="2">
        <location>
            <begin position="18"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="807"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase" evidence="3">
        <location>
            <begin position="66"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4041771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="828" mass="87221" checksum="26A5BFECFA0F8E56" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PJ18</accession>
    <name>A0AAN6PJ18_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid permease-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_16156</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854388">
        <property type="protein sequence ID" value="KAK4039914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PJ18"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000106">
        <property type="entry name" value="Methionine transporter, putative (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF382">
        <property type="entry name" value="LOW-AFFINITY METHIONINE PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="402"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="435"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="474"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="504"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="551"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4039914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="573" mass="63290" checksum="4A0454E144B8632F" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PJA8</accession>
    <name>A0AAN6PJA8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61</fullName>
            <ecNumber evidence="2">2.1.1.220</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit trm61</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 13">tRNA(m1A58)-methyltransferase subunit TRM61</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">C8A01DRAFT_34300</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Heterotetramer; composed of two copies of TRM6 and two copies of TRM61.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.220" evidence="2"/>
    <dbReference type="EMBL" id="MU854353">
        <property type="protein sequence ID" value="KAK4041697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PJA8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031515">
        <property type="term" value="C:tRNA (m1A) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160107">
        <property type="term" value="F:tRNA (adenine(58)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000189">
        <property type="entry name" value="tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049470">
        <property type="entry name" value="TRM61_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014816">
        <property type="entry name" value="tRNA_MeTrfase_Gcd14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133:SF2">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE CATALYTIC SUBUNIT TRMT61A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08704">
        <property type="entry name" value="GCD14"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51620">
        <property type="entry name" value="SAM_TRM61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 16" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61 C-terminal" evidence="15">
        <location>
            <begin position="133"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61 C-terminal" evidence="15">
        <location>
            <begin position="302"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="78"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="383"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="487"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="279"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="390"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="509"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00054081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00063447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00067592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00077998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK4041697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="520" mass="57533" checksum="A964F30A210987AD" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PJE9</accession>
    <name>A0AAN6PJE9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2'-phosphotransferase</fullName>
            <ecNumber evidence="2">2.7.1.160</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_34132</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2'-phosphate from ligated tRNA to NAD to produce ADP-ribose 1''-2'' cyclic phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>2'-phospho-[ligated tRNA] + NAD(+) = mature tRNA + ADP-alpha-D-ribose 1'',2''-cyclic phosphate + nicotinamide</text>
            <dbReference type="Rhea" id="RHEA:23324"/>
            <dbReference type="Rhea" id="RHEA-COMP:11106"/>
            <dbReference type="Rhea" id="RHEA-COMP:11107"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:76596"/>
            <dbReference type="ChEBI" id="CHEBI:82883"/>
            <dbReference type="ChEBI" id="CHEBI:85027"/>
            <dbReference type="EC" id="2.7.1.160"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.160" evidence="2"/>
    <dbReference type="EMBL" id="MU854350">
        <property type="protein sequence ID" value="KAK4041882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PJE9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000215">
        <property type="term" value="F:tRNA 2'-phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.970">
        <property type="entry name" value="RNA 2'-phosphotransferase, Tpt1/KptA family, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002745">
        <property type="entry name" value="Ptrans_KptA/Tpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042080">
        <property type="entry name" value="RNA_2'-PTrans_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01885">
        <property type="entry name" value="PTS_2-RNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="23"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="292"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="297"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4041882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="325" mass="34852" checksum="026E97632944D166" modified="2024-10-02" version="1">MAAAVAVPLSAIHGELGGVLPPSAVVQHSPRHGRSRAMSMKGKGGRQRGYSVVEERDVTVAKALMFVIKRAIQKEDVEEGDGEYLVADPEGWTSVADVLAHSRISALGVTLEDIQRLVATVTKSRFDLRHISNSEGKSEDPASWQISRITNKESVASPVLVGDKLTAETSDLPEFVIYETSYQRYPLLLALGAITRAPGGSEYRTFVPVTVDDGGNESRQTPGSGEAAEVSVWIHLRTAMQAEPSITWQRSDSGAIITADDVPKGLWKKAIARRPEIGLLFENGEVRKEVPANLRGKGAKGKARKGKGTVKQEGSGDDSGSASEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PJF5</accession>
    <name>A0AAN6PJF5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_46899</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854395">
        <property type="protein sequence ID" value="KAK4039640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PJF5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4039640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="344" mass="38563" checksum="F66F30979822EA1F" modified="2024-10-02" version="1">MPSSRRSSQPREPKSSKEPPEILHHLGRAVLSYSLKKLSEQQNAKAAAAQSRPRSQSSRPKSSSRRHSKPRDPSSSSKRDMPRSDSGDMHSLISQLAVGVFAFGIRALIRRRREAKKKAAAAAATAAQAGTRAAVPGGAPGQKPAAAAAAADPELSAALDSVTKELQGASDSIRRLAYAAPPRAHRDCVVRDALVADADRLSGSLANVQASIHNMRNLHPGLERGKRRRERDRPREVPTQEAREREREGRTDARERARGQGQIGEGLRSRGAPRTEETREKSRGVERTEEAAKSERHRRHREHDQPRDQPADSDRHRRRRRRQREERQREEELERGRRREPVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PJJ0</accession>
    <name>A0AAN6PJJ0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ubiquitin-related domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_35729</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854380">
        <property type="protein sequence ID" value="KAK4040306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PJJ0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036435">
        <property type="term" value="F:K48-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032435">
        <property type="term" value="P:negative regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903094">
        <property type="term" value="P:negative regulation of protein K48-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031397">
        <property type="term" value="P:negative regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46340">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46340:SF1">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22562">
        <property type="entry name" value="UBA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBA" evidence="6">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="75"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="UBX" evidence="7">
        <location>
            <begin position="280"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="40"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="91"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="201"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="91"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="114"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="201"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="221"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4040306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="313" mass="34416" checksum="00F1C924460CA6FE" modified="2024-10-02" version="1">MTKSDLDMLLEMGFEQARAELAVKKTGGLQQALNWLEENQDKPLEELQASQAAGAAGGDEEGAASMSSGETASSLVCNECGKKFRNHDQASFHASKTDHTDFSESTEEIAPLTEEEKKARLEDLRQKLKDKRANQSVADKEDAKRNEQIRMKATRESQDVKEELQRKEQIKEAAKKRQEKLEDLEAKKRIKARIEADRLERKRREEDAKAMREGKPLPGQTAAPAAPVVPAASTSGSSAATARLRLQTKNGNLVKSYPSETTLFEVAQQIEAEVGAPINSFSMTFPRKTFEAVDFGQTLAEAGLAPSAVLVVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PJN6</accession>
    <name>A0AAN6PJN6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mitochondrial sorting</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_36281</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854393">
        <property type="protein sequence ID" value="KAK4039745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PJN6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19481">
        <property type="entry name" value="RecA-like_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054289">
        <property type="entry name" value="DUF7025"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411:SF3">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411">
        <property type="entry name" value="FAMILY ATPASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22942">
        <property type="entry name" value="DUF7025"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="2">
        <location>
            <begin position="498"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4039745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="709" mass="80631" checksum="22550094F2097947" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PJT2</accession>
    <name>A0AAN6PJT2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Lipid droplet-associated hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_34677</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lipid droplet</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. LDAH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854360">
        <property type="protein sequence ID" value="KAK4041265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PJT2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019915">
        <property type="term" value="P:lipid storage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019363">
        <property type="entry name" value="LDAH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13390">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13390:SF0">
        <property type="entry name" value="LIPID DROPLET-ASSOCIATED HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10230">
        <property type="entry name" value="LIDHydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0551">Lipid droplet</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="291"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="291"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="303"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4041265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="388" mass="43415" checksum="D73F888BBC977DD3" modified="2024-10-02" version="1">MDDTGTGLNTVTQDQVPFLGYPSSRQDDPGHLQCLIYLIPGNPGLIAYYEPFMKTLRQLLDEKEAVAGCRHAFHIYGRNLLGFQDGDHSPAFGTTTTSGTKTEPFTLEDQIRDVSDHLQQLNTSTLKTGQTFDQVILIGHSVGAYITLELFHRHHHARRVLHTTPTTTSNPPPDPLGTVPLTAAILLFPTISHIARSRSGQKLDLLRTTPFLDRAAHHIAKRFVDLCPGWLLSAVVRRVMGFPAHAVGATLQFLASRDGIWQALHLGKDEMRVIGEERWGEEMWVVQEMVEEEAEEEEGEDEGGVRGREGGEGKAGLGRTKFIFYFAERDHWVADECRDEFIERRRRQEKGRARVVVDEGGVPHAFCIHHSEFVAEKVKGWIGDIAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PJY2</accession>
    <name>A0AAN6PJY2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">D-xylose 1-dehydrogenase (NADP(+), D-xylono-1,5-lactone-forming)</fullName>
            <ecNumber evidence="3">1.1.1.179</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">D-xylose-NADP dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_33591</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>D-xylose + NADP(+) = D-xylono-1,5-lactone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22000"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15867"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.179"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.179" evidence="3"/>
    <dbReference type="EMBL" id="MU854342">
        <property type="protein sequence ID" value="KAK4042384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PJY2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047837">
        <property type="term" value="F:D-xylose 1-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050984">
        <property type="entry name" value="Gfo/Idh/MocA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604">
        <property type="entry name" value="OXIDOREDUCTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604:SF105">
        <property type="entry name" value="TRANS-1,2-DIHYDROBENZENE-1,2-DIOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="7">
        <location>
            <begin position="38"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="361"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="467"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="523"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="478"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="525"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="601"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="621"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00042988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4042384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="686" mass="75946" checksum="FC0990DF85928595" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PK16</accession>
    <name>A0AAN6PK16_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 subunit J</fullName>
            <shortName evidence="5">eIF3j</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 30 kDa subunit homolog</fullName>
            <shortName evidence="5">eIF-3 30 kDa subunit homolog</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">HCR1</name>
        <name evidence="7" type="ORF">C8A01DRAFT_45448</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-3 subunit J family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854358">
        <property type="protein sequence ID" value="KAK4041385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PK16"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.60:FF:000003">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.60">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03009">
        <property type="entry name" value="eIF3j"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023194">
        <property type="entry name" value="eIF3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013906">
        <property type="entry name" value="eIF3j"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21681">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21681:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08597">
        <property type="entry name" value="eIF3_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="232"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="57"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="85"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="101"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="232"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="269"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4041385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="278" mass="29975" checksum="BB087C2387DFAACD" modified="2024-10-02" version="1">MPGPSKRWEEEEEESSSAPDSPVVGAAGVARRKFDDEEAEDSDVLDSWDAAEDSEVEREKAKKAAEAKAKAEAEAAANKKSKTQRIAERQAERAQAKADADASDSEEEDEAEKRERLRRTEKESDLRHAEDLFGSIGISSGRKATTAGSAVPIDASDPTKTVDLSALPLFKPMTKLQFEQLRNTVGPILAGNAKKAHYTLFLQEFTKQLAKDLPSDQIKKIASTLTALSNEKMKEEKAADKGGKKSKAAKTKTSLAGVSRGGGAADTNTYEDEAAFGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PKV2</accession>
    <name>A0AAN6PKV2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Clasp N terminal-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_33099</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Microtubule binding protein that promotes the stabilization of dynamic microtubules. Required for mitotic spindle formation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CLASP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854335">
        <property type="protein sequence ID" value="KAK4042849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PKV2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005881">
        <property type="term" value="C:cytoplasmic microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990023">
        <property type="term" value="C:mitotic spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060172">
        <property type="term" value="P:astral microtubule depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090307">
        <property type="term" value="P:mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024395">
        <property type="entry name" value="CLASP_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21567">
        <property type="entry name" value="CLASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21567:SF9">
        <property type="entry name" value="CLIP-ASSOCIATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12348">
        <property type="entry name" value="CLASP_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TOG" evidence="9">
        <location>
            <begin position="4"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="9">
        <location>
            <begin position="281"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="223"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="510"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="581"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="751"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="228"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="249"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="534"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4042849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1145" mass="122865" checksum="58D9916A92744661" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PL16</accession>
    <name>A0AAN6PL16_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HbrB-like-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_35506</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854376">
        <property type="protein sequence ID" value="KAK4040465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PL16"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038203">
        <property type="term" value="P:TORC2 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Bit61/PRR5"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="493"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="825"/>
        </location>
    </feature>
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            <end position="862"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="916"/>
        </location>
    </feature>
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        </location>
    </feature>
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            <end position="64"/>
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    </feature>
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            <end position="90"/>
        </location>
    </feature>
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            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
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            <begin position="148"/>
            <end position="159"/>
        </location>
    </feature>
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            <end position="219"/>
        </location>
    </feature>
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            <begin position="235"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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            <end position="294"/>
        </location>
    </feature>
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            <end position="308"/>
        </location>
    </feature>
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        <location>
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            <end position="319"/>
        </location>
    </feature>
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        <location>
            <begin position="358"/>
            <end position="371"/>
        </location>
    </feature>
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        <location>
            <begin position="395"/>
            <end position="407"/>
        </location>
    </feature>
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        <location>
            <begin position="418"/>
            <end position="451"/>
        </location>
    </feature>
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        <location>
            <begin position="454"/>
            <end position="474"/>
        </location>
    </feature>
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        <location>
            <begin position="475"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="730"/>
            <end position="752"/>
        </location>
    </feature>
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        <location>
            <begin position="814"/>
            <end position="823"/>
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        <location>
            <begin position="951"/>
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        </location>
    </feature>
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        <location>
            <begin position="971"/>
            <end position="982"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4040465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1009" mass="106342" checksum="F16F9E9ED37F7A86" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PL49</accession>
    <name>A0AAN6PL49_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_32844</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3B4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="P:positive regulation of mRNA splicing, via spliceosome"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNA-binding domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Splicing factor 3b subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
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        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
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        <property type="entry name" value="RRM_dom"/>
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        <property type="entry name" value="SF3B4_RRM1"/>
    </dbReference>
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        <property type="entry name" value="SF3B4_RRM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052084">
        <property type="entry name" value="SF3B4_spliceosome_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48030">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48030:SF3">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="11"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="99"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="299"/>
            <end position="395"/>
        </location>
    </feature>
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        <location>
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            <end position="313"/>
        </location>
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            <end position="342"/>
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    </feature>
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        <location>
            <begin position="386"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4043053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="395" mass="40555" checksum="872DC39C597A8AA1" modified="2024-10-02" version="1">MSKHWEQNKDATVYVGNIDERFTQELLSELMTQVGPVRQVHMPQDRVSQTHQGYGFVEFDTPASAEYASKVLNGIRVWGKPIRVNKASADKQKTVDIGAELFINNLDPQVDEKILYDTFSQFGQILRQPNIVRDDNNISKGYGFVSFDSFEGSDAAVATMNGQYLLSKAITVEYAYKKDGKGERHGDEAERKLAAEGKKHNIVPEQQVLPPAFHMSAQGAAAAPPTGPAIDHPSAAIPPVITPLSAGAGVGMPPTAPYGAIPPVGPAGGMGRAGPPPPSFGGVGGGGGRPPLGVAAAGLPPAPSGLPARPPPSHAGFGGPVGGFPHHSPPPAGFPAGPPPGPAGQLPSSMYPGMPPPPPGGFAGAGAPPGFIPPPGGAVPPGFGAVPPPAGFGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PLE4</accession>
    <name>A0AAN6PLE4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">CAP-Gly domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_44718</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854344">
        <property type="protein sequence ID" value="KAK4042195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PLE4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003857">
        <property type="term" value="F:(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044594">
        <property type="term" value="F:17-beta-hydroxysteroid dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03448">
        <property type="entry name" value="HDE_HSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
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    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054357">
        <property type="entry name" value="MFE-2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13078:SF57">
        <property type="entry name" value="DEHYDRATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G00640)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13078">
        <property type="entry name" value="PEROXISOMAL MULTIFUNCTIONAL ENZYME TYPE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22622">
        <property type="entry name" value="MFE-2_hydrat-2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CAP-Gly" evidence="7">
        <location>
            <begin position="300"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="1123"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="1123"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="629"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="965"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1036"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1185"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="637"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="654"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="977"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="987"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="998"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1014"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1045"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1185"/>
            <end position="1200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4042195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1211" mass="131855" checksum="41B81B65716DA8B5" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PLI2</accession>
    <name>A0AAN6PLI2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">C8A01DRAFT_43917</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat NOL10/ENP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854331">
        <property type="protein sequence ID" value="KAK4043136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PLI2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056551">
        <property type="entry name" value="Beta-prop_NOL10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040382">
        <property type="entry name" value="NOL10/Enp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056550">
        <property type="entry name" value="NOL10_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012580">
        <property type="entry name" value="NUC153"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14927">
        <property type="entry name" value="NUCLEOLAR PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14927:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23098">
        <property type="entry name" value="Beta-prop_NOL10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23097">
        <property type="entry name" value="NOL10_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08159">
        <property type="entry name" value="NUC153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Nucleolar protein 10-like N-terminal" evidence="10">
        <location>
            <begin position="20"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="240"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleolar protein 10-like second" evidence="9">
        <location>
            <begin position="388"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="NUC153" evidence="8">
        <location>
            <begin position="495"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="536"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="540"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="629"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK4043136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="638" mass="71771" checksum="4D91AA6BAC69D9D7" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PN55</accession>
    <name>A0AAN6PN55_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_31707</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854321">
        <property type="protein sequence ID" value="KAK4044109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PN55"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4044109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="285" mass="32068" checksum="308B0BBFF3A7949F" modified="2024-10-02" version="1">MSLPPTPNHFTWERIDIGDLDQDLQHAEHGSDSPNDTPTPPPYSGYARVPPFQGQYQPGRAPDEHDKKDEGDGGDGFIKTALFPLPPTVAENHSHLSPYRYNTFPPPLGPPSTPNSDRETRPHGREQGYFETLDFSDYLPPANPGSANLQQHHLGEKLPSGIYSPRMMPLFESATMDSCTTWQREYVPRAWRDSTIETQARRLYGGYGAVGGRSLDVDCGRTAVGRFALGDKRRKWRAMRFEKTELDVESWEIRRKSVKHELAATREPVELPAFAGRLMHSQSGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PNF0</accession>
    <name>A0AAN6PNF0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_13366</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854332">
        <property type="protein sequence ID" value="KAK4043063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PNF0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00267">
        <property type="entry name" value="ABC_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001332">
        <property type="entry name" value="Similar to ABC transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43158">
        <property type="entry name" value="SKFA PEPTIDE EXPORT ATP-BINDING PROTEIN SKFE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43158:SF2">
        <property type="entry name" value="SKFA PEPTIDE EXPORT ATP-BINDING PROTEIN SKFE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="3">
        <location>
            <begin position="10"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4043063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="293" mass="32519" checksum="4567D5088E0F15CC" modified="2024-10-02" version="1">MAQPQQPPTVETTDLTYTFQDYSTGISHISLSLPSRSRTLLIGANGAGKTTLLRLLAGKRLAPANTIRVAGVDPFKETVQGVTYLGLEWVLNAIVRTDIGVGDLLKSVGGDVYPERRDELVSVLDIDTSWRMHAVSDGERRRVQLAMGLIRPWRVLLLDEITVDLDVWSRAQFLGFLRRETEGRECTVVYATHILDNLAGWPTHLVHMHLGTVKGWGPAEEMLKEVEVRDREEGDGVVGVAGNSKLGELVLRWLRDDLRERGPRSQHKRGPEGWTYSVTGLGGYGFEPKGGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PPN7</accession>
    <name>A0AAN6PPN7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">peptidyl-tRNA hydrolase</fullName>
            <ecNumber evidence="1">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_14043</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an N-acyl-L-alpha-aminoacyl-tRNA + H2O = an N-acyl-L-amino acid + a tRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:13883"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59874"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:138191"/>
            <dbReference type="EC" id="3.1.1.29"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PTH2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1"/>
    <dbReference type="EMBL" id="MU854343">
        <property type="protein sequence ID" value="KAK4042325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PPN7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:peptidyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02430">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1490.10:FF:000001">
        <property type="entry name" value="Peptidyl-tRNA hydrolase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1490.10">
        <property type="entry name" value="Bit1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023476">
        <property type="entry name" value="Pep_tRNA_hydro_II_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002833">
        <property type="entry name" value="PTH2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00283">
        <property type="entry name" value="arch_pth2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003314">
        <property type="entry name" value="PRK04322.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12649">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12649:SF11">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01981">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102462">
        <property type="entry name" value="Peptidyl-tRNA hydrolase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4042325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="223" mass="23691" checksum="9ABF8F3664BB2D48" modified="2024-10-02" version="1">MSETTPAIIVTTTLIAFISGFGLGVYTIRGWWLVSPDLAAERAANLHDPVESDESDVDEEATLLDHAPNWANGAEADRRQGLRANTGGGGAGIKFDAREECKMVLVVRTDLGMTKGKIAAQCSHATLACYKSLLRAAQQAPQSSEAKVLRQWERLGQAKIAVQVKSEDELLELMGKARSLGVTAEVIADAGRTQIASGSRTVLGVGPAPKSLVDMVTGHLKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PPQ7</accession>
    <name>A0AAN6PPQ7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_13698</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854337">
        <property type="protein sequence ID" value="KAK4042706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PPQ7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="481"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="579"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="632"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="416"/>
        </location>
    </feature>
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            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="633"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="690"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="704"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="772"/>
            <end position="787"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4042706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="794" mass="86448" checksum="0FD73FA3A9084CFE" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PQ05</accession>
    <name>A0AAN6PQ05_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_32796</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854331">
        <property type="protein sequence ID" value="KAK4043154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4043154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="109" mass="12379" checksum="158AE8454C3C0D8A" modified="2024-10-02" version="1">MTDYATETASWYVWLTELSIIPQEYRYIINLISSFFITLALTPIVPIAVLVIYDLMLWFWRLAVANWRARSAPRIVVAEPPELPANGTALNGSLRPTHTDGLHPAKRPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PR59</accession>
    <name>A0AAN6PR59_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin carboxyl-terminal hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_43891</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854331">
        <property type="protein sequence ID" value="KAK4043105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PR59"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
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        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="3">
        <location>
            <begin position="625"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="576"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="580"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4043105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1012" mass="111631" checksum="97FE7B58F6C46659" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PRN6</accession>
    <name>A0AAN6PRN6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MBOAT, membrane-bound O-acyltransferase family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_12575</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854322">
        <property type="protein sequence ID" value="KAK4044054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PRN6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003841">
        <property type="term" value="F:1-acylglycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047184">
        <property type="term" value="F:1-acylglycerophosphocholine O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046474">
        <property type="term" value="P:glycerophospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030258">
        <property type="term" value="P:lipid modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049941">
        <property type="entry name" value="LPLAT_7/PORCN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13906:SF4">
        <property type="entry name" value="LYSOPHOSPHOLIPID ACYLTRANSFERASE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13906">
        <property type="entry name" value="PORCUPINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="381"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="420"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="455"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="489"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="492"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="504"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4044054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="547" mass="61965" checksum="BEFB5BA56E522A47" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PU30</accession>
    <name>A0AAN6PU30_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">60S ribosomal protein L43</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_31101</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854317">
        <property type="protein sequence ID" value="KAK4044605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PU30"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.30:FF:000002">
        <property type="entry name" value="60S ribosomal protein L37a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00327">
        <property type="entry name" value="Ribosomal_eL43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011331">
        <property type="entry name" value="Ribosomal_eL37/eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002674">
        <property type="entry name" value="Ribosomal_eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050522">
        <property type="entry name" value="Ribosomal_protein_eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00280">
        <property type="entry name" value="eL43_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003058">
        <property type="entry name" value="PRK03976.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48129">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L37A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48129:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01780">
        <property type="entry name" value="Ribosomal_L37ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4044605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="92" mass="10146" checksum="32C68E7D07A646F8" modified="2024-10-02" version="1">MSKRTKKVGISGKYGTRYGASLRKLVKKQEVSQHARYTCTFCGKNTVRRSAVGIWNCKACKKTMAGGAYTVATPAAAAMRSTLRRLREITEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SKN5</accession>
    <name>A0AAN6SKN5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_42344</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU855048">
        <property type="protein sequence ID" value="KAK4031169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SKN5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4031169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="64" mass="6848" checksum="F986E4BCE5C5187A" modified="2024-10-02" version="1" fragment="single">MPPRRRPPAPGAPSTSAPKPGARPSKLAKEHNITAEEEAEIREAFSLFAEPLDGEKEGIMPIGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SL53</accession>
    <name>A0AAN6SL53_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_41851</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854724">
        <property type="protein sequence ID" value="KAK4031694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SL53"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="172"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4031694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="533" mass="59146" checksum="9580C1630F2F2A80" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SLQ3</accession>
    <name>A0AAN6SLQ3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_21111</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854717">
        <property type="protein sequence ID" value="KAK4031725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SLQ3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4031725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="309" mass="32561" checksum="78A1C5C6B980C766" modified="2024-10-02" version="1">MAPQSCELHFVPLKTPLPPTESAHLLGRVVRSYDDLRWAYTPESPEATLTPARFALFLAEPQHSHDVRLTAHATSSSSAFADFFAGASASTTAAGTVTVAAPRVTTRQLRNEGQYFEALKADGTVRRKLLDMCPVNDQVYLVVGTKSARGGASYERTTHTGRSASRGVSLPLGAAAGAAAMATGVPVIAPDLSGGVVPDLKAGFERDRLAGGTASFTFAGGEAEEVFAVACRVVRRTWRGLGKDMGLGMTQPEYTGGIHFGSDSESDESEDEDGGVDENELSEEDEVALAQGLELGELVVCGPLDLDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SML8</accession>
    <name>A0AAN6SML8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_20249</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854582">
        <property type="protein sequence ID" value="KAK4032700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SML8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043038670" evidence="1">
        <location>
            <begin position="18"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4032700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="114" mass="11844" checksum="5AE2748284499C17" modified="2024-10-02" version="1">MHLSISFLSYLAALAVAAPQAIDYGPCDYNGNDNCKEIMDNTACFLNPVGANEIFKCISGGRDGVCACYGCLGYTPVGEVIAKSSACAGFPTSSPVKLGDIPTVTPAPTPKLKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SNS9</accession>
    <name>A0AAN6SNS9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_19002</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854493">
        <property type="protein sequence ID" value="KAK4034137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SNS9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="323"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4034137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="519" mass="56020" checksum="367F8BB5C4781AE0" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SNU0</accession>
    <name>A0AAN6SNU0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7136 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_18042</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854450">
        <property type="protein sequence ID" value="KAK4035261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SNU0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055560">
        <property type="entry name" value="DUF7136"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23584">
        <property type="entry name" value="DUF7136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042820166" description="DUF7136 domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7136" evidence="3">
        <location>
            <begin position="29"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="257"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4035261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="300" mass="32037" checksum="818D1F4E1D9FC058" modified="2024-10-02" version="1">MGYSLRRFAVLALAVAASSQQTPPPNINQPFEVDAIFPRPFEQTLAMEDLQKFKPNEIIPLVIAVQNMTAWTVGNQTVSWEWDIMSLPADGTRGRIVDAGIFDTADAVKTNPAFLVAVTNSSTWYQNTSAASVPPKTPGDTYLFQWTASIYTLNDSCAFQYPRIPNRYVWYTASVFDVLTESEQEERHNVTTAVVAIPQAPECPELNGIYQATFNETATECQLGVVAVETIQGNPCAARVDSAIASSISSRVASSTSAWTAPTTTTAPAATSTSSGGAGVAHPVQTAMAAACLLCGLALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SP34</accession>
    <name>A0AAN6SP34_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="9">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">C8A01DRAFT_18428</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. SKI2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="9"/>
    <dbReference type="EMBL" id="MU854464">
        <property type="protein sequence ID" value="KAK4034829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.10:FF:000012">
        <property type="entry name" value="DEAD/DEAH box DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000012">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.10">
        <property type="entry name" value="Sec63 N-terminal domain-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052247">
        <property type="entry name" value="Meiotic_Crossover_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057842">
        <property type="entry name" value="WH_MER3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47835:SF3">
        <property type="entry name" value="HELICASE FOR MEIOSIS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47835">
        <property type="entry name" value="HFM1, ATP DEPENDENT DNA HELICASE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02889">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23445">
        <property type="entry name" value="WHD_SNRNP200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00973">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0469">Meiosis</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="44"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="254"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="981"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1122"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1205"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1263"/>
            <end position="1282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="988"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="999"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1013"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1122"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1221"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK4034829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1309" mass="145782" checksum="F6B98D01DC96E10C" modified="2024-10-02" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SQ85</accession>
    <name>A0AAN6SQ85_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">40S ribosomal protein S5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_37922</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854438">
        <property type="protein sequence ID" value="KAK4038151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SQ85"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14867">
        <property type="entry name" value="uS7_Eukaryote"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.455.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="entry name" value="Ribosomal protein S7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000235">
        <property type="entry name" value="Ribosomal_uS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020606">
        <property type="entry name" value="Ribosomal_uS7_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_uS7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_uS7_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005716">
        <property type="entry name" value="Ribosomal_uS7_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003106">
        <property type="entry name" value="PRK04027.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01028">
        <property type="entry name" value="uS7_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11205">
        <property type="entry name" value="RIBOSOMAL PROTEIN S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002122">
        <property type="entry name" value="RPS7p_RPS7a_RPS5e_RPS7o"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="Ribosomal protein S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00052">
        <property type="entry name" value="RIBOSOMAL_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS7" evidence="5">
        <location>
            <begin position="54"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4038151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="212" mass="23586" checksum="DD17B189A4381BF4" modified="2024-10-02" version="1">MSEGEVEVASSSYEVLPKEVLAEVGSVKLFNRWSYEDVEIRDISLTDYIQIRSPVYLPHSAGRYAAKRFRKANCPIIERLTNSLMMHGRNNGKKLMAVRIVAHSFEIIHLMTDQNPIQIAVDAIVNCGPREDSTRIGSAGTVRRQAVDVSPLRRVNQAIALLTTGAREASFRNVKSIAECLAEELINAAKGSSNSYAIKKKDELERVAKSNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SQ88</accession>
    <name>A0AAN6SQ88_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_36980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854411">
        <property type="protein sequence ID" value="KAK4039079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SQ88"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4039079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="154" mass="17121" checksum="7FC1780BB4FB409E" modified="2024-10-02" version="1">MSSDNTTPNWLSIPPTDPNPFIGHHLTRAVRNFHIMGQVVFRSPTCAMHKEAIMSEYMKTLDVSDIRSIADYCCQYLVYVTVPSSMEEHLQWMAVLVAFEALPASGIPRETIRMLVQDDQWRCMIHACPGCQKEPGRGEEAGVCDGGFGVCGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SQI5</accession>
    <name>A0AAN6SQI5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RlpA-like double-psi beta-barrel-protein domain-containing protein-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_37616</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854429">
        <property type="protein sequence ID" value="KAK4038436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SQI5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22191">
        <property type="entry name" value="DPBB_RlpA_EXP_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051477">
        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF28">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042910047" evidence="3">
        <location>
            <begin position="18"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="64"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="66"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4038436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="247" mass="25769" checksum="2E39CF0CD7012B5A" modified="2024-10-02" version="1">MKSIVFVASLLASLAAAQPHGHGHGHQHRRKEHEHHERGLAVTWVTETVYETVTAIVDDSTTELIMPSTKPATTTSSTPGPSPGMFFPGPDTSSTTSTTPTQAPPVVQPPPPPPPPPAPAPSPSTTSVAAPPVDTPPPSSGGSPTYSGDITYFALGMGSCGIDDSLLDRTHNVVAVSAQLMGAQSNGNPMCGKTITIQANGKTITAVVHDKCPSCAPGDIDGSEKMFVDLFGALTDGRRKIEWWFNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SQK2</accession>
    <name>A0AAN6SQK2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Genetic interactor of prohibitins 3, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_37132</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854415">
        <property type="protein sequence ID" value="KAK4038947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SQK2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050896">
        <property type="entry name" value="Mito_lipid_metab_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46434">
        <property type="entry name" value="GENETIC INTERACTOR OF PROHIBITINS 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46434:SF1">
        <property type="entry name" value="GENETIC INTERACTOR OF PROHIBITINS 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="677"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="381"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="694"/>
            <end position="708"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4038947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="716" mass="79195" checksum="2A22BBD1FDB83E37" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SQP0</accession>
    <name>A0AAN6SQP0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_17391</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854426">
        <property type="protein sequence ID" value="KAK4038528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SQP0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="55"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4038528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="285" mass="31186" checksum="9FB640937E5DC98B" modified="2024-10-02" version="1">MAFNAGPLPKQAAALLTGKAKVATYESTGGKTTFKFAAHNLALVPAIKPGSTIHDNACGAGTVSRYILQNGLLDVKIHATDIDQPFLDVLAEDAAQHGWPVEVSNQKSEATSFDDAFFDYDIMNIGIIFMSSAGLDATREMHRTLKPGGFAVVNCWKAITWMLPIMLVHKAFRGEATPFPAPPVNWTDGTQLRKVLVDAGFEETKIHLESHEVSTVLDEGEEFREWVEKTWAFLAGIGGWHQVDEEKWDEEVDMLAALLKKQPGTMVEGGKVTMTASQWVAVAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SR51</accession>
    <name>A0AAN6SR51_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_16868</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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            <end position="59"/>
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            <end position="89"/>
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            <end position="170"/>
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        <source>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="222" mass="23679" checksum="3CEDBA41658BEA58" modified="2024-10-02" version="1">MRPSGHRGDDSWTSFGQRRGLSDTARFGLDLTRTRAGSGGAAGPASYPSPPMSGTPPLPLKISHEVAERSQGTYQATTQDVYSSISTTQNEERTRAGVAGGPRPFLSDTPERAPYAFPRLDGPTARPLPYPQPLGQAATQPTAYLPGPGTGMVPNHPGSLPPPEPYPPAAHHPVPDALQNTPPKPQRKTKGHVASACVPCKRAHLRFVLPVLTHHQVRNTKC</sequence>
</entry>
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    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854394">
        <property type="protein sequence ID" value="KAK4039695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-0732">Signal</keyword>
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            <begin position="1"/>
            <end position="21"/>
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            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4039695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="119" mass="13212" checksum="5A76F2CB753A5F23" modified="2024-10-02" version="1">MQLNTASLVAAALAFAATASADSLIVHQYCLTLACNNPGTWHSAYGDFFVDAGEGCRDPDIPGMWSLCIDEGNARGHFYFDNQPKRCIKQTDNDFEKCSDDYQFATCSVIYYDEVPCTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SRW1</accession>
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        <recommendedName>
            <fullName evidence="5">BZIP domain-containing protein</fullName>
        </recommendedName>
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        <name evidence="6" type="ORF">C8A01DRAFT_45862</name>
    </gene>
    <organism evidence="6 7">
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    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854368">
        <property type="protein sequence ID" value="KAK4040834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SRW1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050936">
        <property type="entry name" value="AP-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018287">
        <property type="entry name" value="Hap4_TF_heteromerisation"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621:SF7">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10297">
        <property type="entry name" value="Hap4_Hap_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Leucine zipper domain"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="130"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
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        </location>
    </feature>
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            <begin position="535"/>
            <end position="545"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
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    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="647" mass="68081" checksum="B25D92149C6A26E8" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SSH0</accession>
    <name>A0AAN6SSH0_9PEZI</name>
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            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
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        <lineage>
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            <taxon>Fungi</taxon>
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    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="MU854357">
        <property type="protein sequence ID" value="KAK4041449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SSH0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="58"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK4041449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="418" mass="47229" checksum="235114D24D49F9DE" modified="2024-10-02" version="1">MVLRVILSSGINRLKPIPGRAPKQIDAVRAFSEESISRYCDGGYHPVRIGDVFNNGQYKIVNKLGYGVYSTVWLACNTQTKRHVALKILTADSYGRQQDTFELDILGHIKAQSQTTPNPGSSHILGLLDMFEHVGPHGNHLCLVFKAMGPDMSRYRRLFPKQRIQIPLMKEISRQLLLALSCLHNECRVIHTDIKPQNMLVETPAISIMFEQAPSHVFLLQRSPAEPPNDFFMESTQVSSAEEDLTRPTDLSVRLADFGTSSWLDRHLTEWIQPQMLRAPEVILGADWDYKVDIWNLGLILWELAEGQLLFDGSWTPAAPYSSEAHLAQMTAIFGKMSAALLARSKNRDRYFDSEGNLLKSSFPPCSLEQFSKVPDLSDAERKVYLDFIKSMIRMDPYNPPPFPTSTIDLTYSITTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SSK9</accession>
    <name>A0AAN6SSK9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cation efflux protein transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_46141</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854375">
        <property type="protein sequence ID" value="KAK4040508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SSK9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098771">
        <property type="term" value="P:inorganic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1350:FF:000004">
        <property type="entry name" value="Cation diffusion facilitator 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000005">
        <property type="entry name" value="Putative Cation diffusion facilitator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="entry name" value="Cation efflux protein, cytoplasmic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050291">
        <property type="entry name" value="CDF_Transporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840:SF4">
        <property type="entry name" value="CDF DIVALENT METAL CATION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840">
        <property type="entry name" value="MITOCHONDRIAL METAL TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="265"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="308"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="340"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="7">
        <location>
            <begin position="239"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4040508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="525" mass="58641" checksum="B05843358AA297D8" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SSM6</accession>
    <name>A0AAN6SSM6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2-dehydropantoate 2-reductase</fullName>
            <ecNumber evidence="2">1.1.1.169</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Ketopantoate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_35375</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ketopantoate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.169" evidence="2"/>
    <dbReference type="EMBL" id="MU854373">
        <property type="protein sequence ID" value="KAK4040611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SSM6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008677">
        <property type="term" value="F:2-dehydropantoate 2-reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003710">
        <property type="entry name" value="ApbA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050838">
        <property type="entry name" value="Ketopantoate_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00745">
        <property type="entry name" value="apbA_panE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43765:SF2">
        <property type="entry name" value="2-DEHYDROPANTOATE 2-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43765">
        <property type="entry name" value="2-DEHYDROPANTOATE 2-REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketopantoate reductase N-terminal" evidence="6">
        <location>
            <begin position="5"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Ketopantoate reductase C-terminal" evidence="7">
        <location>
            <begin position="233"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4040611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="373" mass="40303" checksum="EFC49DFA65647512" modified="2024-10-02" version="1">MDKGIHILGLGNLGKYVAYGLRRSQQTIAASGHLLPVTLIFHRDGLLADWKSADRSIWYTCNTSQTSPAAKKSRATGFRVELLANAAAGNREAEGQPDVTVGSNAPIRHLIVATKTYATAAALAPIKHRLSKDSDILFLQNGMGVTDEVSEKLFPDPDTRPTYWAGICSAGVYSTAPFSLVHAGHGPLAIGLVAGGRSSNLPPPMEENPMVAQLLNAPVLEAGLNSPVRSVGDQLRKLVINSIINPLTALFNCKNGHVFESHEGEDLFRHLLQEAGPIVRALFPDQSNLFLHEAFSDEFLGKLVKSVVTATANNTSSMLQDIQAGRRTEIDYINGYLVSQGERLGLPTTHHAAVYGRIKKLEAGHREQHVQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6STI0</accession>
    <name>A0AAN6STI0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_34226</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854352">
        <property type="protein sequence ID" value="KAK4041735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6STI0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="106"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4041735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="179" mass="19105" checksum="7F9BA42D81002030" modified="2024-10-02" version="1">MPAPKDDSEKPPVFPTPRARLEYLYHDVTRLSQIAAPTLILHRADRNLTSPPRPPVVGIKAAQQYEEDFVAATGGTLVMDVESMTVDCDGVFGCVMGVLRAGGGSSSSSSSSSLVGGQGVSVGGKGQGKEDSQEGNSKGRGEIEMRFCGVWRFDEEGRAVEHWENAADPAALARWLGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SU78</accession>
    <name>A0AAN6SU78_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">CRM1 C terminal-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_44687</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. Involved in pre-tRNA splicing, probably by affecting the interaction of pre-tRNA with splicing endonuclease.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the exportin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854343">
        <property type="protein sequence ID" value="KAK4042306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SU78"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000490">
        <property type="entry name" value="CRM1p Major karyopherin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041123">
        <property type="entry name" value="CRM1_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041235">
        <property type="entry name" value="Exp1_repeat_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045065">
        <property type="entry name" value="XPO1/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014877">
        <property type="entry name" value="XPO1_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040485">
        <property type="entry name" value="XPO1_repeat_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223">
        <property type="entry name" value="EXPORTIN 1/5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223:SF2">
        <property type="entry name" value="EXPORTIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08767">
        <property type="entry name" value="CRM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18777">
        <property type="entry name" value="CRM1_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18784">
        <property type="entry name" value="CRM1_repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18787">
        <property type="entry name" value="CRM1_repeat_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01102">
        <property type="entry name" value="CRM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Exportin-1 C-terminal" evidence="9">
        <location>
            <begin position="693"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1035"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1035"/>
            <end position="1048"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4042306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1064" mass="121686" checksum="8F75072BF1A63879" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SU81</accession>
    <name>A0AAN6SU81_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Superoxide dismutase 1 copper chaperone</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Superoxide dismutase copper chaperone</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">C8A01DRAFT_13161</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CCS1 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the C-terminal section; belongs to the Cu-Zn superoxide dismutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854329">
        <property type="protein sequence ID" value="KAK4043294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SU81"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006801">
        <property type="term" value="P:superoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000038">
        <property type="entry name" value="Superoxide dismutase 1 copper chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="entry name" value="Superoxide dismutase, copper/zinc binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024134">
        <property type="entry name" value="SOD_Cu/Zn_/chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001424">
        <property type="entry name" value="SOD_Cu_Zn_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10003">
        <property type="entry name" value="SUPEROXIDE DISMUTASE CU-ZN -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00080">
        <property type="entry name" value="Sod_Cu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="Cu,Zn superoxide dismutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMA" evidence="11">
        <location>
            <begin position="6"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK4043294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="265" mass="27889" checksum="25784DA509E47C86" modified="2024-10-02" version="1">MAVITPFQTLFAVPMTCDGCAKDITGALHKLPGITKVEANVADQLVSVEGTAAPSAIVEAIQATGRDAILRGSGTSNSAAVSILETYYHRADAEVTPAGTPGESWVNERLVRGLVRMVQVSPTETLVDLTVRGVPPGTYRATIREYGNLKDGASSAGPVWSAQSKEGGAAASSPRGVLGTVEIGPNGYGNAFINRPFQVWEVIGHALVVSRHDESDGAPLRNEEDTVVGVIARSAGVWDNDKTVCSCTGKTLWQERKDEVSKGML</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SUH5</accession>
    <name>A0AAN6SUH5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tip elongation aberrant protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_33395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854339">
        <property type="protein sequence ID" value="KAK4042591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SUH5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23244:SF471">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23244">
        <property type="entry name" value="KELCH REPEAT DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="90"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4042591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="564" mass="59886" checksum="DDE5B0C72F5E9113" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SVC6</accession>
    <name>A0AAN6SVC6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fungistatic metabolite</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_43563</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854327">
        <property type="protein sequence ID" value="KAK4043433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SVC6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051589">
        <property type="entry name" value="Sialate-O-sulfotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45964">
        <property type="entry name" value="WSCD FAMILY MEMBER CG9164"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45964:SF5">
        <property type="entry name" value="WSCD FAMILY MEMBER CG9164"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042987092" evidence="2">
        <location>
            <begin position="17"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="3">
        <location>
            <begin position="16"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="3">
        <location>
            <begin position="125"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4043433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="219" mass="22798" checksum="E23DAEBAB85F06A8" modified="2024-10-02" version="1">MQRFLALAALVPATLAQTCYGCYTEAPGRALTGSSTVDYTTMTIADCETYCTGLSFTLWGVEYSGECYCGNALAQGSFPAFSTDCNMACAGDPTAICGGPNRLSLYGSSTTPPTVTPNPHPAVTTTQYEGYWTEATGPRALSGASAYSGTAMILADCGNYCLNSGFTWFGTEYSSECYCGNALDSTSTLVADTDCAMACSGAPGEVCGGPNRLSVYQWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SVF6</accession>
    <name>A0AAN6SVF6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Multidrug resistance-associated protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">C8A01DRAFT_32454</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854327">
        <property type="protein sequence ID" value="KAK4043523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042592">
        <property type="term" value="P:homeostatic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18595">
        <property type="entry name" value="ABC_6TM_MRP1_2_3_6_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18603">
        <property type="entry name" value="ABC_6TM_MRP1_2_3_6_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000565">
        <property type="entry name" value="ABC bile acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000020">
        <property type="entry name" value="ABC metal ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000450">
        <property type="entry name" value="ABC transporter C family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000001">
        <property type="entry name" value="ATP-binding cassette subfamily C member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056227">
        <property type="entry name" value="TMD0_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF443">
        <property type="entry name" value="MULTIDRUG-RESISTANCE LIKE PROTEIN 1, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24357">
        <property type="entry name" value="TMD0_ABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="113"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="461"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="578"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="992"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1033"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1121"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1223"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="16">
        <location>
            <begin position="319"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="15">
        <location>
            <begin position="643"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="16">
        <location>
            <begin position="993"/>
            <end position="1277"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="15">
        <location>
            <begin position="1314"/>
            <end position="1549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="870"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="915"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="922"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="953"/>
            <end position="971"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAK4043523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="19">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1555" mass="172806" checksum="07FF63D121EF5566" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SVH9</accession>
    <name>A0AAN6SVH9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_43536</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAK4043598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="225"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="341"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="9"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4043598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="670" mass="74178" checksum="8D6881784B018885" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SVK9</accession>
    <name>A0AAN6SVK9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Succinate dehydrogenase assembly factor 3</fullName>
            <shortName evidence="8">SDH assembly factor 3</shortName>
            <shortName evidence="8">SDHAF3</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_12819</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 8">Interacts with the iron-sulfur protein subunit within the SDH catalytic dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the complex I LYR family. SDHAF3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854325">
        <property type="protein sequence ID" value="KAK4043688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SVK9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034553">
        <property type="term" value="P:mitochondrial respiratory chain complex II assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006105">
        <property type="term" value="P:succinate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20270">
        <property type="entry name" value="Complex1_LYR_SDHAF3_LYRM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008381">
        <property type="entry name" value="SDHAF3/Sdh7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13137">
        <property type="entry name" value="DC11 ACN9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13137:SF6">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13233">
        <property type="entry name" value="Complex1_LYR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4043688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="130" mass="14798" checksum="ADA0FE665510D66A" modified="2024-10-02" version="1">MRPSLRLLASAMPSGKGLSPGPMALLPPIYLYRRLLRAHRRHLPSEMRLLGDEYVKAEFRAHREVENPVHLIGFLTEWQLYAQKIEGDAWLGEKLDQGKLAKMSDEQLGQLYELMKAIQKRGTEGQGSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SVS7</accession>
    <name>A0AAN6SVS7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_31996</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854323">
        <property type="protein sequence ID" value="KAK4043898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SVS7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046670">
        <property type="entry name" value="DUF6540"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20174">
        <property type="entry name" value="DUF6540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4043898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="150" mass="16831" checksum="E97C2B9248B37516" modified="2024-10-02" version="1">MSYNVYLAESLGGGNSDHHAILLEPAASRSTAHGIEPSCFIFQVKDSVAQGMTYEFRDARDEDFFLGKTLLGTVDADDFNCIDRVCAALPPPKKQFHGPKRLYPREKLYKCQAWTRDALRALAAEGVLRNPYGVPWQDIHEGRRTGTWSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P554</accession>
    <name>A0AAN6P554_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_51131</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854672">
        <property type="protein sequence ID" value="KAK4031954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P554"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4031954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="292" mass="32295" checksum="3205AD4BA940B524" modified="2024-10-02" version="1">MAPHTFIFTNSPYKLNQISLASFVPNLQQPHQDAERTYQVQEPDYDIQDDESFDVVLNSSSESHLKAAATKFASIFGNKDKSDQFQVQASKGRIYSLKQPDALFRKLVSGDDGIAETQRWLEDCKMRGLTPRFVVAFRTLVDARLAASEREGIAFGGKITAPVGEALGGDPTGMADIMGEASHESRKEAQGGMKTPGERIYAIGYRKVKLTYRRGKVMASLPSLENTWESFASPRGDMEADDGVGEEDEDSDVYVKADLLEGDDDKDCRVYSVPKLDGETEAFGILIDDKAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P660</accession>
    <name>A0AAN6P660_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein CAP22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_50798</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854614">
        <property type="protein sequence ID" value="KAK4032394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P660"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042924429" description="Protein CAP22" evidence="2">
        <location>
            <begin position="21"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="146"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4032394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="203" mass="20816" checksum="6B22A28F2DCB4CE8" modified="2024-10-02" version="1">MHTTAATTLFLAVIVSLVHAEELKASDVPNACKAICGPMVTLTSTCDVDPDTETRRRRLRHRADDDNTADDESDEVVEAQCICNNTSFNVRSVAALCAACISQNGKTTDDMDKIISQCSFSSTTFIPGAITAVAGVTVKATKPAFTTSGSSTPTGSNSGSGAGGSTPKASSTGTSAGVMSFDLKTMRLGLAAAAVGAASFLFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P681</accession>
    <name>A0AAN6P681_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_21556</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU855008">
        <property type="protein sequence ID" value="KAK4031193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P681"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4031193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="85" mass="9709" checksum="7771E02355451340" modified="2024-10-02" version="1" fragment="single">IANTPSRPYRNRTLERCTAATTIDRNGQEVDIPYERCWNVKPRRRYVIVPSSNKCSGYIRLGKKYSSPNVISACTSRLFSPIDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P7F9</accession>
    <name>A0AAN6P7F9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">60S ribosomal protein L7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_50200</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854548">
        <property type="protein sequence ID" value="KAK4033154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P7F9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01657">
        <property type="entry name" value="Ribosomal_L7_archeal_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1390.20:FF:000002">
        <property type="entry name" value="60S ribosomal protein L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1390.20:FF:000003">
        <property type="entry name" value="60S ribosomal protein L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="entry name" value="Ribosomal protein L30, ferredoxin-like fold domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="Ribo_uL30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039699">
        <property type="entry name" value="Ribosomal_uL30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005998">
        <property type="entry name" value="Ribosomal_uL30_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035808">
        <property type="entry name" value="Ribosomal_uL30_euk_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016082">
        <property type="entry name" value="Ribosomal_uL30_ferredoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012988">
        <property type="entry name" value="Ribosomal_uL30_N_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01310">
        <property type="entry name" value="uL30_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00327">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08079">
        <property type="entry name" value="Ribosomal_L30_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="Ribosomal protein L30p/L7e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL30 N-terminal eukaryotes" evidence="6">
        <location>
            <begin position="14"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL30-like ferredoxin-like fold" evidence="5">
        <location>
            <begin position="90"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4033154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="249" mass="28746" checksum="74921F806959488A" modified="2024-10-02" version="1">MAPTTVPTQNDVLVPETLLKKRKSQEKARAERTAEQDKQKKANKEKRGVIFKRAEKYVKEYRDGEREKIRLARLAKQDGSFYIPAEAKLIFVIRIKGINKIPPKPRKILQLLRLLQINNGVFVRITKATSEMIKVVEPWVAYGYPNLKSVKELIYKRGYGKINGQRIPLTDNAIIEENLGKYGIICMEDLIHEIMTVGPNFKQASNFLWPFKLSNPNGGFRTRKFKHFIEGGDLGNREEHINALIRQMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P7M9</accession>
    <name>A0AAN6P7M9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Psi-producing oxygenase A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_51605</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854943">
        <property type="protein sequence ID" value="KAK4031236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P7M9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20612">
        <property type="entry name" value="CYP_LDS-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09817">
        <property type="entry name" value="linoleate_diol_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="entry name" value="Haem peroxidase domain superfamily, animal type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050783">
        <property type="entry name" value="Oxylipin_biosynth_metab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034812">
        <property type="entry name" value="Ppo-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11903">
        <property type="entry name" value="PROSTAGLANDIN G/H SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11903:SF37">
        <property type="entry name" value="PSI-PRODUCING OXYGENASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00457">
        <property type="entry name" value="ANPEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50292">
        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1 6" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="361"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR619791-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4031236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1066" mass="118216" checksum="8FE6711952F2AD04" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P832</accession>
    <name>A0AAN6P832_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Sec61beta family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">C8A01DRAFT_40092</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SEC61-beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854529">
        <property type="protein sequence ID" value="KAK4033459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P832"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005784">
        <property type="term" value="C:Sec61 translocon complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030671">
        <property type="entry name" value="Sec61-beta/Sbh"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016482">
        <property type="entry name" value="SecG/Sec61-beta/Sbh"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13509">
        <property type="entry name" value="SEC61 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03911">
        <property type="entry name" value="Sec61_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK4033459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="124" mass="12314" checksum="EA9D5413B3AAF03B" modified="2024-10-02" version="1">MSSPRAASPPTGSAAGGASTGSATGASTPGAGGRPSSPPPPGGARTAIRRRAAADQKDKIANARPNSTRSAGAGGSSSTMLRLYTDESPGLKVDPVVVLVLSLVFIFSVVALHIIAKITRKFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P8B0</accession>
    <name>A0AAN6P8B0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_19491</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854521">
        <property type="protein sequence ID" value="KAK4033594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P8B0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042826620" evidence="3">
        <location>
            <begin position="23"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="350"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="384"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="424"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="476"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="525"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="535"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4033594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="624" mass="68750" checksum="EB87FEEC4344A285" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2025-10-08" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P8F2</accession>
    <name>A0AAN6P8F2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ABC-2 type transporter-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">C8A01DRAFT_40891</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854586">
        <property type="protein sequence ID" value="KAK4032660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03233">
        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001010">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000054">
        <property type="entry name" value="ABC multidrug transporter atrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029481">
        <property type="entry name" value="ABC_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034001">
        <property type="entry name" value="ABCG_PDR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14510">
        <property type="entry name" value="ABC_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
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        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
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    </evidence>
    <sequence length="1477" mass="164923" checksum="51678B039C2AB132" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAN6P8H2_9PEZI</name>
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            <fullName evidence="5">Transmembrane protein</fullName>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
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                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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</entry>
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
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                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
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                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
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                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4033769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="482" mass="55542" checksum="A509663A23B60240" modified="2024-10-02" version="1">MAAFEEFDEAAWDYGDELFETWKKGLYNKDLYYEIGWKIMKHHMGGNGLELCAPQRGGFDVYYRLRMAEGAGAMIRFPMPAYFQYAEEKLLAEVATIRYLSDNTAIPIPFILHYGIKQESPGELGPFIIMEWVENAGDLVDITNKPGLTNEDVPMLDPDIDDEKLERVYGQMAGILLQLSQCEFPAIGSLNFPNGDDDLDPEVLTRPLSINISQLANFARVPHFQLPPPSKTFKTSSEYYTALADMHLQQLSFQRNQAVESADDCRKKYIARQLFRKLALEGRLAEDKSFNHGPFKLWCDDLRPANVLVNKDETLAAAIDWEFTYAAPADFSFAPPWWLLLQAPDDWRAGLDDWVAHYEPRLAVFLRALETKEKQLIEQGRLLGEAEVPPPLSARMRRSWETGHFWVVYAARRAWAFDGIYWRFLDEKFFGRNESGDFMERLKLLPLEQIEAMEGFVERKPKEKEEGMLVDWYEPGAESRVI</sequence>
</entry>
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    <accession>A0AAN6P8R5</accession>
    <name>A0AAN6P8R5_9PEZI</name>
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        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_20156</name>
    </gene>
    <organism evidence="2 3">
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        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854572">
        <property type="protein sequence ID" value="KAK4032825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P8R5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF5">
        <property type="entry name" value="BTB_POZ DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="11"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4032825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="174" mass="19550" checksum="CEC1A73784465702" modified="2024-10-02" version="1" fragment="single">LNRYFNADTFADAVVRCNGKEFKVHRLVLSSQSEFFETAAGLVELGEADDSVIEAMLRFMYCFDYNNIHGVSTMIFNAQVYSLSDKYMIPALKDLAKEKFRSAINTGWAMDDFPLTVAEVYSSTPEDDGGLRDLAVKVADTNIKRLLQNEQFRDLLKKSPGFAADMVISMSSNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P8V6</accession>
    <name>A0AAN6P8V6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_50382</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854562">
        <property type="protein sequence ID" value="KAK4032947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P8V6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022085">
        <property type="entry name" value="OpdG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053204">
        <property type="entry name" value="Oxopyrrolidines_Biosynth-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38797:SF4">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38797">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP85-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12311">
        <property type="entry name" value="DUF3632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4032947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="261" mass="28960" checksum="CA368EEA21642F40" modified="2024-10-02" version="1">MAATETSFATLMQLELVKKRDLTAQGVSILQALAHGLQPATPEAAAEAAHQLDRLCPPLEDSDQASDYLWGLWEIIMAIAGSPDVESEVHERLVEILRQLKQHARGELGFSLDPTSTGAEFTQVSAQIWRNISLFGARYLAERLLGAYLELAYTLRDALEQDLDKLPDVGIAECRIQVACGWIQYAAKPLLRWAWENMDSTNGSFYCGPSAVCLERWRFWLGRFDELANEDSGLGEETRKAASEAAETMRAVEKLVDDALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P9U2</accession>
    <name>A0AAN6P9U2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_18806</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854482">
        <property type="protein sequence ID" value="KAK4034384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P9U2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052400">
        <property type="entry name" value="Zn2-C6_fungal_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN ECM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657:SF7">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN ECM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4034384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="349" mass="39126" checksum="F1F0EC088F38C59F" modified="2024-10-02" version="1" fragment="single">SKAKSHSPVSPASTSTPRPDRASTLPEGGELPLLELELLHNFTTKTYTTLTADPCLWEFWRDDVVQLGLTCDYIMRAVLAVSALHLAYHRPDRRDFYVEEGILLHQKAARSAMRVMAAGNKLDRDQAASLFLFSMLTIFFALASPRRSNPDGTFFIGESGFPDWAFLLSGSKSIMDVLGESGLDTVVGPFLHYGRGRWRAQRALLEAKLTSQPPDSPPEPPLLAPLRARIHAAVSDPSLLQTYTHALDELELALVVRQDPAAPRDVLDAMVWLWVVSDEFVPLLRVPTQEAVAIFAHFCVLLKHHESHWWLQGWGDHVMVRAREILDGEHRGWIEWPVREMGWGEGAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PA25</accession>
    <name>A0AAN6PA25_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_18690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854476">
        <property type="protein sequence ID" value="KAK4034519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PA25"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="169"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4034519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="347" mass="36312" checksum="DE3DE4BA0BBC4E8D" modified="2024-10-02" version="1">MAETYGPAGRDGQLHVGGQIHGPNGPDHSTLEVVPSHDYDRAAFGRNDKIAYVPSRENDKVVVEPPYEHVYPEQVHPGPYSPQTRLAQGGSAWDGDAWTTGMGGDPGTGKRERICGLKRRTFFIVLWVVSILVAIGVGVGTGVGVSLHSSNNSSGTEADATASGADMATRSTSSLPTTETSPATTSTIPSGAVTSTTRTSTFRSRSVSALPSDGAVQIGGPGGRCTSEHWGTDCICLDGNVCRNTWKGATYTGNSRDNYPCPNDPPAIVACIVKPCLGKSAPSQCIWREACAQVDNSKPSPFILLAPVLSASGFPDPYLDRLLTGSTRVATARCPGGDDFVCCDALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2025-10-08" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PAP1</accession>
    <name>A0AAN6PAP1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Acyl-coenzyme A diphosphatase SCS3</fullName>
            <ecNumber evidence="6">3.6.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">FIT family protein SCS3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">SCS3</name>
        <name evidence="6" type="synonym">FIT2B</name>
        <name evidence="13" type="ORF">C8A01DRAFT_50052</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Fatty acyl-coenzyme A (CoA) diphosphatase that hydrolyzes fatty acyl-CoA to yield acyl-4'-phosphopantetheine and adenosine 3',5'-bisphosphate. Preferentially hydrolyzes unsaturated long-chain acyl-CoA substrates in the endoplasmic reticulum (ER) lumen. This catalytic activity is required for maintaining ER structure and for lipid droplets (LDs) biogenesis, which are lipid storage organelles involved in maintaining lipid and energy homeostasis. May directly bind to diacylglycerol (DAGs) and triacylglycerol, which is also important for LD biogenesis. May support directional budding of nacent LDs from the ER into the cytosol by reducing DAG levels at sites of LD formation. May play a role in the regulation of cell morphology and cytoskeletal organization. Involved in phospholipid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = S-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:65568"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57368"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:156554"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(9Z)-octadecenoyl-CoA + H2O = S-(9Z-octadecenoyl)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:65564"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:156553"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>an acyl-CoA + H2O = an acyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:50044"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:132023"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>hexadecanoyl-CoA + H2O = S-hexadecanoyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:50032"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:132018"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Endoplasmic reticulum membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the FIT family. Fungal FIT2B/SCS3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="6"/>
    <dbReference type="EMBL" id="MU854536">
        <property type="protein sequence ID" value="KAK4033338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003877">
        <property type="term" value="F:ATP:ADP adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010945">
        <property type="term" value="F:coenzyme A diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140042">
        <property type="term" value="P:lipid droplet formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23668">
        <property type="entry name" value="GH55_beta13glucanase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000023">
        <property type="entry name" value="Exo-beta-1,3-glucanase Exg0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000026">
        <property type="entry name" value="Exo-beta-1,3-glucanase Exg0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03231">
        <property type="entry name" value="SCS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009163">
        <property type="entry name" value="Ap4A_phos1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043171">
        <property type="entry name" value="Ap4A_phos1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045759">
        <property type="entry name" value="Ap4A_phos1/2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019200">
        <property type="entry name" value="ATP_adenylylTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019388">
        <property type="entry name" value="FIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024535">
        <property type="entry name" value="RHGA/B-epi-like_pectate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046400">
        <property type="entry name" value="SCS3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38420:SF3">
        <property type="entry name" value="5',5'''-P-1,P-4-TETRAPHOSPHATE PHOSPHORYLASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38420">
        <property type="entry name" value="AP-4-A PHOSPHORYLASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19327">
        <property type="entry name" value="Ap4A_phos_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09830">
        <property type="entry name" value="ATP_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10261">
        <property type="entry name" value="FIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12708">
        <property type="entry name" value="Pect-lyase_RHGA_epim"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5 6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042843445" description="Acyl-coenzyme A diphosphatase SCS3" evidence="9">
        <location>
            <begin position="34"/>
            <end position="1538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="924"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="954"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1086"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1112"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase" evidence="11">
        <location>
            <begin position="65"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase" evidence="11">
        <location>
            <begin position="407"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="Ap4A phosphorylase 1/2 N-terminal" evidence="12">
        <location>
            <begin position="1163"/>
            <end position="1311"/>
        </location>
    </feature>
    <feature type="domain" description="ATP adenylyltransferase C-terminal" evidence="10">
        <location>
            <begin position="1399"/>
            <end position="1530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="788"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1208"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1311"/>
            <end position="1340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="834"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1223"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="1016"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="1106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF09830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF19327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK4033338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1538" mass="166525" checksum="47E286BC21F5C6C3" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PBG2</accession>
    <name>A0AAN6PBG2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_38228</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854448">
        <property type="protein sequence ID" value="KAK4035326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PBG2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4035326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="337" mass="36587" checksum="C71EEAC9F39FD098" modified="2024-10-02" version="1">MPQYSPPVLTTSVAVAHLYNGTVLTITKTPATPAYTALMERIGNAPEPPPPGRLAKWQRWWNKKRGQPATADVGVLSSLLISLKAATVSALGGQPVDRVAVTGPSTPALINQDLHDALEHAGLRSWLGDGSRYQPRRIAQCRAVFAGNGHGLCPSYTDLFQCWSEGGDMASRLTLFVSLTRHALYASVDEIREAFPKSAWGGDDGLRVLDFDGGLDGRGRFASEGDYWAHVRGRIVGLARQSSRPLQRVLLGGENATNSAFLATLRDALAELSPVSPLRVDVAMIEDPTYAAARGMAVYARRRQEVPGDCMERLVCDERREKERSGASEGSPRLELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PC25</accession>
    <name>A0AAN6PC25_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Telomeric repeat-binding factor 2-interacting protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Repressor/activator protein 1 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">C8A01DRAFT_48143</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RAP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854436">
        <property type="protein sequence ID" value="KAK4038207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PC25"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070187">
        <property type="term" value="C:shelterin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031848">
        <property type="term" value="P:protection from non-homologous end joining at telomere"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010833">
        <property type="term" value="P:telomere maintenance via telomere lengthening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16100">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23767">
        <property type="entry name" value="IQCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11655">
        <property type="entry name" value="rap1_myb-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036431">
        <property type="entry name" value="ARID_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021661">
        <property type="entry name" value="Rap1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038104">
        <property type="entry name" value="Rap1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039595">
        <property type="entry name" value="TE2IP/Rap1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015010">
        <property type="entry name" value="TERF2IP_Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16466">
        <property type="entry name" value="TELOMERE REPEAT-BINDING FACTOR 2-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16466:SF6">
        <property type="entry name" value="TELOMERIC REPEAT-BINDING FACTOR 2-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08914">
        <property type="entry name" value="Myb_Rap1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11626">
        <property type="entry name" value="Rap1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46774">
        <property type="entry name" value="ARID-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0779">Telomere</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BRCT" evidence="15">
        <location>
            <begin position="17"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="TERF2-interacting telomeric protein 1 Myb" evidence="13">
        <location>
            <begin position="109"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="TERF2-interacting telomeric protein 1 Myb" evidence="13">
        <location>
            <begin position="234"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="TRF2-interacting telomeric protein/Rap1 C-terminal" evidence="14">
        <location>
            <begin position="961"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="159"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="250"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="408"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="585"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="166"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="183"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="325"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="447"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="590"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="731"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="875"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="926"/>
            <end position="937"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF11626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF16589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK4038207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1077" mass="119765" checksum="7EC0D56194F84789" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PCN8</accession>
    <name>A0AAN6PCN8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Allergen Asp f 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_48746</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854459">
        <property type="protein sequence ID" value="KAK4034972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PCN8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019863">
        <property type="term" value="F:IgE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038903">
        <property type="entry name" value="Allergen_Asp_f_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42039">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42039:SF1">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25312">
        <property type="entry name" value="Allergen_Asp_f_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042949390" description="Allergen Asp f 4" evidence="1">
        <location>
            <begin position="18"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4034972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="294" mass="31106" checksum="9320C5F2C0640F2D" modified="2024-10-02" version="1">MQLPHFLLLAGALGAAAHPSGHAHLHRSVHAKREEPVYVKAVRKPIPIPTTTSQAPEPTPTVAASPAVKVAAAVDDVTDAVFKAFCGSSSSKSKRVTYDQIMYTGNLGTNNGCAWNSNLMEVSNSIADKYQNVQKYTNVANEPYQVICANKMGKDGQLTGMFEVPGQTPLIFMLQPGETKTVVADADTQGVCAFAPNKVPQTEHGQYAGVWAEFDFSSKPNKGWSGADCSSLVAQAYKMDVPGCRMSHGGIDSTILPGGKGTNAYTIGMEQLDGVGLNIFPGKSVIEVKVGFSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PCW9</accession>
    <name>A0AAN6PCW9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_47834</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854425">
        <property type="protein sequence ID" value="KAK4038568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PCW9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046523">
        <property type="term" value="F:S-methyl-5-thioribose-1-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43475">
        <property type="entry name" value="METHYLTHIORIBOSE-1-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43475:SF3">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G14290)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="12"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4038568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="529" mass="57815" checksum="8EA9CF722AAC175C" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PD63</accession>
    <name>A0AAN6PD63_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GTP-binding nuclear protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_37329</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the small GTPase superfamily. Ran family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854420">
        <property type="protein sequence ID" value="KAK4038762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PD63"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00877">
        <property type="entry name" value="Ran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000131">
        <property type="entry name" value="GTP-binding nuclear protein Ran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002041">
        <property type="entry name" value="Ran_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24071:SF0">
        <property type="entry name" value="GTP-BINDING NUCLEAR PROTEIN RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24071">
        <property type="entry name" value="RAN GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00627">
        <property type="entry name" value="GTPRANTC4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51418">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4038762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="217" mass="24408" checksum="FEEEBFB5608532E6" modified="2024-10-02" version="1">MAEAAQNQTPTFKLVLVGDGGTGKTTFVKRHLTGEFEKKYMATLGVEVHPLGFSTNFGQIQFDVWDTAGQEKFGGLRDGYYINGQCGIIMFDVTSRITYKNVPNWHRDLTRVCENIPIVLCGNKVDVKERKVKAKTITFHRKKNLQYYDISAKSNYNFEKPFLWLARKLVGNAGLEFVAAPALAPAEVQVDHKLLAQYEAEMQAATNEPLPDDEDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PEA5</accession>
    <name>A0AAN6PEA5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase</fullName>
            <ecNumber evidence="3">1.1.1.302</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">C8A01DRAFT_39160</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes an early step in riboflavin biosynthesis, the NADPH-dependent reduction of the ribose side chain of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, yielding 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NAD(+) = 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27274"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58890"/>
            <dbReference type="ChEBI" id="CHEBI:59545"/>
            <dbReference type="EC" id="1.1.1.302"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NADP(+) = 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27278"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58890"/>
            <dbReference type="ChEBI" id="CHEBI:59545"/>
            <dbReference type="EC" id="1.1.1.302"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HTP reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.302" evidence="3"/>
    <dbReference type="EMBL" id="MU854482">
        <property type="protein sequence ID" value="KAK4034382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PEA5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="entry name" value="Dihydrofolate Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050765">
        <property type="entry name" value="Riboflavin_Biosynth_HTPR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38011:SF11">
        <property type="entry name" value="2,5-DIAMINO-6-RIBOSYLAMINO-4(3H)-PYRIMIDINONE 5'-PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38011">
        <property type="entry name" value="DIHYDROFOLATE REDUCTASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_8G06820)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="Dihydrofolate reductase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0686">Riboflavin biosynthesis</keyword>
    <feature type="domain" description="Bacterial bifunctional deaminase-reductase C-terminal" evidence="10">
        <location>
            <begin position="84"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK4034382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="203" mass="21617" checksum="5E5E79A7B5EFBC18" modified="2024-10-02" version="1">MPLLRYNLAPTLNGLITSHPTNTTPWIVPDPTIDFPSLYAEFSTFLLGRKTYETFLSMPPGDNPLLGRPKESVVVFTRDSVKAKEWEGDVTVVGSGSGLGSAGVVEFVRGLMGELKRKGPDGEGGKDVWLMGGGEVAGMLLRAGLVDVVEAAIMPVVVGQGAKMFGEGDGEGDKGEAGWKLVLEKAEALASGILMTRYRVVYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PEY1</accession>
    <name>A0AAN6PEY1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">GPN-loop GTPase 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_38370</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Binds to RNA polymerase II (RNAPII).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854453">
        <property type="protein sequence ID" value="KAK4035166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PEY1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17872">
        <property type="entry name" value="GPN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000552">
        <property type="entry name" value="GPN-loop GTPase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030228">
        <property type="entry name" value="Gpn3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF7">
        <property type="entry name" value="GPN-LOOP GTPASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4035166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="299" mass="33900" checksum="40419174F9623600" modified="2024-10-02" version="1">MSKYGVMVMGPAGVGKSTFCASLITHLQLNRRSAFYVNLDPAAEHFEHEPDVDIKELISLEDVMEDDEMRWGPNGGLIYCFEFLMQNLDFLAEKLDSLTEEYLIIFDMPGQIELYTHIPVLPTLIKFLTQPGALDIRLCAAYLLEATFVVDRAKYFAGSLSAMSAMIMLEVPHLNILSKMDLVKDQMRKKDFKRFLVPDTTLLEDDPADTVRKRMGVEVDVHSSDPADKDALMSGATFKRLNAAVANLLENFSMVNYLKLDSTDEESVQAILSYIDDCIQYHEAQEPKELAEEEFEEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PF28</accession>
    <name>A0AAN6PF28_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Kynureninase</fullName>
            <ecNumber evidence="5 6">3.7.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Biosynthesis of nicotinic acid protein 5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">L-kynurenine hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BNA5</name>
        <name evidence="8" type="ORF">C8A01DRAFT_47044</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25143"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36559"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:58125"/>
            <dbReference type="EC" id="3.7.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>L-kynurenine + H2O = anthranilate + L-alanine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16813"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:57959"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="3.7.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 6">Amino-acid degradation; L-kynurenine degradation; L-alanine and anthranilate from L-kynurenine: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 6">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the kynureninase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.7.1.3" evidence="5 6"/>
    <dbReference type="EMBL" id="MU854399">
        <property type="protein sequence ID" value="KAK4039477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PF28"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030429">
        <property type="term" value="F:kynureninase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043420">
        <property type="term" value="P:anthranilate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097053">
        <property type="term" value="P:L-kynurenine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019805">
        <property type="term" value="P:quinolinate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000031">
        <property type="entry name" value="Kynureninase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01970">
        <property type="entry name" value="Kynureninase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010111">
        <property type="entry name" value="Kynureninase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01814">
        <property type="entry name" value="kynureninase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14084">
        <property type="entry name" value="KYNURENINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14084:SF2">
        <property type="entry name" value="KYNURENINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22580">
        <property type="entry name" value="KYNU_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038800">
        <property type="entry name" value="KYNU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 6" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="4 5 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="7">
        <location>
            <begin position="139"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="192"/>
            <end position="195"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="350"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="378"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5">
        <location>
            <position position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PIRNR" id="PIRNR038800"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4039477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="505" mass="55900" checksum="25C0411B2D035DED" modified="2024-10-02" version="1">MDAEYQSFIKTLRAGHKPEFPADAKSIEYARLLDAQDKLSFLRANFNIPTRSPLRKRALDGTVPGAVKQLDISNGTKHVKGDAKEDAPSIYFVGNSLGAQPKCVRQYLNAQLETWASIGVNGHFTSLDNSPLTAWQDMAADCAQQSLDLVGAASASEVIYMNTLTVNLHLMMASFYRPTERRHKIIAEWKPFPSDSYAIASQLQWHGLSPSTSLVEIHPDPETMYISTEHILSVIDEHADSTALLLLPGIQYYTGQLFNIPLITSHARARGITVGWDLAHAVGNAELFLHAWDVDFAVWCTYKYLNAGPGAIAGAFVHERHHHHGHHHHSTPDPEKGVDVVGYLPRLAGWYGADKTTRFNMDKVFRPAEGAHGWQMSNPSVVDLACVRAALAVFGQTDMRALRDKAVVLTGYLEWLLMGLLKDNFGEPAFRIITPGNPLERGSHLSLLLRPGLLDRVSETLAAGGVVVDVRKPDVIRVAPVPMYCRFEDVWGFIEVLKTALEEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PFM4</accession>
    <name>A0AAN6PFM4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_36782</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854406">
        <property type="protein sequence ID" value="KAK4039223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PFM4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4039223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="553" mass="61902" checksum="3A3160C4D8568EF9" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PFZ3</accession>
    <name>A0AAN6PFZ3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_15803</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
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            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854380">
        <property type="protein sequence ID" value="KAK4040299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PFZ3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025836">
        <property type="entry name" value="Zn_knuckle_CX2CX4HX4C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051714">
        <property type="entry name" value="Znf_CCHC_NABP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23002">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14392">
        <property type="entry name" value="zf-CCHC_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="83"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="106"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="146"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="293"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="322"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="345"/>
            <end position="360"/>
        </location>
    </feature>
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            <begin position="369"/>
            <end position="384"/>
        </location>
    </feature>
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            <begin position="391"/>
            <end position="406"/>
        </location>
    </feature>
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        <location>
            <begin position="415"/>
            <end position="430"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="448"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="459"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="472"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4040299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="497" mass="53567" checksum="9AC9088D0D8368E1" modified="2024-10-02" version="1">MSAWDSSNNNSGWGGGGATAADSGWGGPAATTDSGWDTGPTANGNTDNWNNDASGAASGGDNFGMDTMNLNEDAGNGGGDRGCFNCGEQGHNKADCPNPRVLSGACRRCNQEGHWSKDCPNAPPMKCRAECESTDHMVKDCPNRVCKNCGETGHTVSQCKNARKIDREHIPEMSTDEAWAAIKRAVKERDIDDAKEAIQAYVKSSPEATYADLERAFRAQDVSIWLIAIEKPLASTFTNMDLQGNLGKKYTVTYRFQWNPPRPRDREVWPKDVDENIERLGDAGEVVYGGLPKCRNCDEIGHIAKSCPQDQLEKPSAFEITCFNCGETGHRVRDCPTPRVDRFACKNCGFSGHKVADCPEPRSADDVECRKCGEMGHFSRDCPQGGGSSGCRNCGQEGHMARDCTEPRNMANVQCRNCDEFGHMNKDCPKPRDSDNCQEMGHFKSRCPNPLVPEDDAGDFGGGGAENGGFGDAQADTGAGNDDAGDWNTAATGTGGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PG88</accession>
    <name>A0AAN6PG88_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_35589</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
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            <taxon>Ascomycota</taxon>
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            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854377">
        <property type="protein sequence ID" value="KAK4040449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PG88"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="106"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="146"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="176"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="335"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="364"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4040449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="410" mass="40888" checksum="38E56B8F93C3299C" modified="2024-10-02" version="1">MSLAPHPLLLWRTAPPPRPPRAPRRRPASTTTTTTTTICFGDKEFTAAAASASREASPAPSEGSHTSSADADGDNDSLFGDVSPAEAKSASSLSGSSPDNKAPQEPAAGPASSAPSFGSIPDHVIAAAFAELAEEDPAEWGHLSFPSAAPSAPAPPVTAAVAAPGPPFQGGICGTSLLSLPSARASGPSSAPAPFPAAAAAPPPPAASPADQQQLETLPAPPAAQTAGKGKGKTKTKAARPAPAPAPAPTAAPVPTVSARTERRRAEKDSVAHIAARLQLNRANTTSSSFVSGRRKIWQYHADAAAAAPVASWFPTADNNNDDSAEDEEDEEEYGAAVVGSSVIGVGASAEMPVAVGDDEDDISNGSNSGSSSSSSRNSRNSSNSSNSSKKSAAPATAGADHAVAAPVAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PGE6</accession>
    <name>A0AAN6PGE6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Mitochondrial carrier domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">C8A01DRAFT_46205</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854376">
        <property type="protein sequence ID" value="KAK4040488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PGE6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000112">
        <property type="entry name" value="Mitochondrial carrier protein (Pet8), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45667">
        <property type="entry name" value="S-ADENOSYLMETHIONINE MITOCHONDRIAL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="9"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="100"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="223"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK4040488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="314" mass="33178" checksum="27D4EFA7DE7581AD" modified="2024-10-02" version="1">MATAAPSPPPFQTALLAGALAGTTVDLSLFPLDTLKTRLQSSAGFFASGGFRGIYRGIGSALVGSAPGAAFFFCTYEASKTFLASSPTFQHLTNGHNRGGQAVEHMLAASLGEIAACAVRVPTEVVKQRAQAGQHGGSSLRSLLHILRQQHTVGLVGVWRELYRGWGITVMREVPFTILQFPLWEALKAWGRERRARTGRGLFGDVGTHPGREGAAVGIVGEVSAAESAVYGSISGGVAAAVTTPLDVLKTRVMLSAQRESMASIVRTIVKENGIRPFFAGIGPRVMWISAGGAIFLGSYQWAVNALEKSRLVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PGJ8</accession>
    <name>A0AAN6PGJ8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_46073</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854373">
        <property type="protein sequence ID" value="KAK4040599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PGJ8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4040599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="107" mass="12272" checksum="14D815EE23111460" modified="2024-10-02" version="1">MVVRIPAATRTEVFCMGAAGVTGFAPFYLMAPGAEERLSKQTVKWAPRWERNITMFRNPVERGIQRVSPPIERTVQRIEHRLPLEKAAKQTDKNIKRTLDRMGIKHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PGM4</accession>
    <name>A0AAN6PGM4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Tyrosinase copper-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_37889</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854437">
        <property type="protein sequence ID" value="KAK4038185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PGM4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF126">
        <property type="entry name" value="TYROSINASE-LIKE PROTEIN TYR-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00497">
        <property type="entry name" value="TYROSINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042915272" description="Tyrosinase copper-binding domain-containing protein" evidence="4">
        <location>
            <begin position="20"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="5">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="6">
        <location>
            <begin position="225"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="252"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4038185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="323" mass="35246" checksum="025FB8481F3018E6" modified="2024-10-02" version="1">MAQISKLVACLLMVCSAFAACTNPAKRRAWHTLSKAEKLEYINAELCLMKKPARLGLPAAKTRFDELQAIHQLQAYATHFVGAFLPFHRMMMYAHESALRNECNYTGYQPYWYEQQDAGNFRNSVLFDATYGFGGNGVGANGCIATGPFANYTNSLGPGYDNTQHCINRAISDQTSTGSRQANVDACLRLTTFETAWPCIEGQPHTGGHGGVGGQMLNGVSSPGDPLFYLHHTWLDKVFWDWQAKDRATRTTTIGGTNVGPDYSPGFPPRPSNIPKPTGAAGDPGTTTTLGHVLNMYGNSPNRTIGDVLDIQGGFLCYEYVEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PHP3</accession>
    <name>A0AAN6PHP3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cyclochlorotine biosynthesis protein O</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_36674</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the ustYa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854402">
        <property type="protein sequence ID" value="KAK4039376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PHP3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF4">
        <property type="entry name" value="CYCLOCHLOROTINE BIOSYNTHESIS PROTEIN O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0843">Virulence</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4039376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="266" mass="30414" checksum="24A2ECB7F4E6C00C" modified="2024-10-02" version="1">MVAGDDYQPVPLLDDEKQSETGSWKTRSSLDAFYQTPPARRISQHWVWIAHIGLLSVSTALFTLSFCLRYARPSSLAVTTQFSTYSPAAPIVQYDTQRYNLTPNMDWSPYVGKGPEVDEAWEQISRVGDMMISLDEVHRLGLSPDSLKITDPKTGKVGYRAAIEVFHQLHCLNLLRQFTWREHYANEGGDIDAPPEDVRGHVDHCLETLRMNLMCQADIGVFTFKVYPELGDDDPWPDFSTLHTCRNFEDIRTWARKRAVTWDDNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PI98</accession>
    <name>A0AAN6PI98_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_36533</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854399">
        <property type="protein sequence ID" value="KAK4039494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PI98"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4039494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="160" mass="17936" checksum="9181760A7B15937E" modified="2024-10-02" version="1">MGSTTLIRGFKVAVATLDAFLAANDVDETYGTPPFYGDHPDKDSISRLLFAKIAQHDPTADKDRFRVLIPSIEGMARAKTAYVAYAWVPVRAHREVKMDENLPAEIPKGFEELRQEVLAYEMDAKDENKIADEGKLGMYLVVTYDIRGYYGLELDNSEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PID3</accession>
    <name>A0AAN6PID3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNA helicase</fullName>
            <ecNumber evidence="4">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">C8A01DRAFT_16880</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="4"/>
    <dbReference type="EMBL" id="MU854410">
        <property type="protein sequence ID" value="KAK4039115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PID3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17959">
        <property type="entry name" value="DEADc_DDX54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000865">
        <property type="entry name" value="ATP-dependent RNA helicase DDX54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012541">
        <property type="entry name" value="DBP10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033517">
        <property type="entry name" value="DDX54/DBP10_DEAD-box_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF8">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08147">
        <property type="entry name" value="DBP10CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01123">
        <property type="entry name" value="DBP10CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
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            <end position="114"/>
        </location>
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            <end position="499"/>
        </location>
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            <end position="50"/>
        </location>
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        </location>
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            <end position="917"/>
        </location>
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    <feature type="short sequence motif" description="Q motif" evidence="14">
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            <begin position="86"/>
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        </location>
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            <end position="362"/>
        </location>
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        <source>
            <dbReference type="PROSITE" id="PS51192"/>
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            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK4039115.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="917" mass="100695" checksum="A4D7938EB5952FF0" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PIK4</accession>
    <name>A0AAN6PIK4_9PEZI</name>
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        <recommendedName>
            <fullName evidence="8">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="9" type="ORF">C8A01DRAFT_14589</name>
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        <name type="scientific">Parachaetomium inaequale</name>
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10">CBS 284.82</strain>
        </source>
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        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="274"/>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PIW6</accession>
    <name>A0AAN6PIW6_9PEZI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854356">
        <property type="protein sequence ID" value="KAK4041487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PIW6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4041487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="217" mass="24769" checksum="B3DD6C9CC8086E8C" modified="2024-10-02" version="1">MAESIDVSSGSQDGTLRATGSIIDMLNFFDKMDDLIVNSGKEVRDSYNPNAFLVSEGEFSLLAMAKRQYREADHSTEAIRAYLLRLPELDEIWGKICLGILRYLRYDPSRMGEWRFWLKQVERAGTLAWQKALNATKPIADTYEEDRLAMTNALIQKFAVVDEVLDEMHRDLNGVLERDVRFSAELDDSIQAVIAITRQVAQLTPEILQMFKAAIRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PJ32</accession>
    <name>A0AAN6PJ32_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_47042</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854399">
        <property type="protein sequence ID" value="KAK4039475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PJ32"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
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        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_6G01830)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_6G01830)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13578">
        <property type="entry name" value="Methyltransf_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4039475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="237" mass="26205" checksum="044A8E31B8D95526" modified="2024-10-02" version="1">MSQSAASSAISASPRVHALLRRLHAASASQEKALSKTWFYFKRLVAFYLFSTPWGAAADDHMRDKFVALEEDKCHFMYLLARSAGALNIVEAGTSFGVSTIYLALASVSGKVVATEKEPSKAARAREHWAEAGDEVTGVIELREGDLLETLKRDDMPEQVDFLLLDIWTPMALPTLKIIKPRLKTGGIVLADNTSMARPMYHEYLDYIQDPANGFKTTEVPYSGGLQMSVYLPEQSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PJ55</accession>
    <name>A0AAN6PJ55_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF676 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_47068</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854399">
        <property type="protein sequence ID" value="KAK4039505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PJ55"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47842:SF2">
        <property type="entry name" value="DUF676 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47842">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="538"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="538"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="566"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4039505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="606" mass="65867" checksum="89EDC4142D1134CB" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PJB0</accession>
    <name>A0AAN6PJB0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Oxidation resistance protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_15184</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May be involved in protection from oxidative damage.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OXR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854365">
        <property type="protein sequence ID" value="KAK4041010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PJB0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354:SF62">
        <property type="entry name" value="MUSTARD, ISOFORM V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354">
        <property type="entry name" value="NUCLEOLAR PROTEIN 7/ESTROGEN RECEPTOR COACTIVATOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TLDc" evidence="7">
        <location>
            <begin position="139"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="59"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="238"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="83"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4041010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="354" mass="38537" checksum="9CADE97F30B2D3CB" modified="2024-10-02" version="1">MAFYASNHNQPLRSRHLPDLDLSPASSRSVTPPGATSPSSSAFFTSSVSSLWGGFMRRFSSEPSPSTPNPPGLPHARTFQPDGESKYRQDGHGHGNGLDGVYTPPHLLHPHRTASPMRPPPLEPLQLLGFSEETRQDARLLTAPIAEEIRIMVPARLGIVDEWRLVYSLEQDGASLATLYEKCARYQGVRVGFVLCVKDCDGGLFGAYLSDHPHPAPKYFGTGECFLWRASILSPLPPPPSTIDDNDNHAASRTTTIPGPAPPVSNNEKHPSRPATPHPIRFKAFPYSGINEYYMLCEPHFLSLGAGDGKYGLWLDDSLDRGVSATSQTFGNEPLSDEGEKFGVLGVEVWVIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PJI8</accession>
    <name>A0AAN6PJI8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Glycosyl hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_15899</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854382">
        <property type="protein sequence ID" value="KAK4040184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PJI8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18833">
        <property type="entry name" value="GH43_PcXyl-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041542">
        <property type="entry name" value="GH43_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051795">
        <property type="entry name" value="Glycosyl_Hydrlase_43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812">
        <property type="entry name" value="BETA-XYLOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812:SF17">
        <property type="entry name" value="BETA-XYLOSIDASE C-TERMINAL CONCANAVALIN A-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17851">
        <property type="entry name" value="GH43_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043050744" evidence="8">
        <location>
            <begin position="19"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-xylosidase C-terminal Concanavalin A-like" evidence="9">
        <location>
            <begin position="349"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="555"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="34"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="5">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4040184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="579" mass="62798" checksum="D1A3C51E00522039" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PK20</accession>
    <name>A0AAN6PK20_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">C8A01DRAFT_33767</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854345">
        <property type="protein sequence ID" value="KAK4042132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PK20"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042917696" description="CFEM domain-containing protein" evidence="10">
        <location>
            <begin position="16"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="11">
        <location>
            <begin position="410"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="183"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="564"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="184"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="242"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="586"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK4042132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="629" mass="63703" checksum="CE778B48A41AAB39" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PK34</accession>
    <name>A0AAN6PK34_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">MATE efflux family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_46068</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854373">
        <property type="protein sequence ID" value="KAK4040591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PK34"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052031">
        <property type="entry name" value="Membrane_Transporter-Flippase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43549:SF2">
        <property type="entry name" value="MULTIDRUG RESISTANCE PROTEIN NORM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43549">
        <property type="entry name" value="MULTIDRUG RESISTANCE PROTEIN YPNP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="248"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="323"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="351"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="394"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="442"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="478"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="508"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="21"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="25"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="42"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4040591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="544" mass="59299" checksum="DC34B9B20B13A332" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PK96</accession>
    <name>A0AAN6PK96_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Heterokaryon incompatibility protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_14163</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854344">
        <property type="protein sequence ID" value="KAK4042237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PK96"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26639">
        <property type="entry name" value="Het-6_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="380"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4042237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="968" mass="107258" checksum="A0DCE2AD640F5467" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PKC4</accession>
    <name>A0AAN6PKC4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CWC16 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_14013</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CWC16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854342">
        <property type="protein sequence ID" value="KAK4042377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PKC4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007590">
        <property type="entry name" value="Saf4/Yju2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111">
        <property type="entry name" value="SPLICING FACTOR YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111:SF2">
        <property type="entry name" value="SPLICING FACTOR YJU2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04502">
        <property type="entry name" value="Saf4_Yju2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="310"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="271"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4042377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="373" mass="40797" checksum="1084B74D0CBF6806" modified="2024-10-02" version="1">MQGFNMGRYIPPSAAGTTTSGNALHGKRHALGSRAAKLASHGILIVRFEMPFAIWCATCPQPTPIGQGVRFNAEKRRAGSYYTTPIWSFKLKHSVCGGEIEMRTDPKQGEFVVVSGARRREYAQDEDESLVKSGVGVGFVITTERERAEQRESAFGKLEKTIADREQVAGATQRIGELRDAAERRWDDPYAQNRRLREAFRAGRHARETEAAKAEELRERMGLGIELLPETEEDARRAGLVDFGGVDGEGDDGVGRALARPLFGDVVLAQKEKGDGEKSKRGSRKLKSEMAATRMRESLVSEIVSNTRAAKDPFLDFGSSRESTPKGPVRLPGLKRKRPAEAAPDSPQPAAKQDSPKEVAGTAALVNYNSDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PKQ7</accession>
    <name>A0AAN6PKQ7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Utp21 specific WD40 associated putative domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_33997</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854349">
        <property type="protein sequence ID" value="KAK4041893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PKQ7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000565">
        <property type="entry name" value="Putative snoRNA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059157">
        <property type="entry name" value="WDR36-Utp21_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007319">
        <property type="entry name" value="WDR36/Utp21_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22840">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22840:SF12">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25171">
        <property type="entry name" value="Beta-prop_WDR36-Utp21_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25168">
        <property type="entry name" value="Beta-prop_WDR36-Utp21_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04192">
        <property type="entry name" value="Utp21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="WDR36/Utp21 N-terminal" evidence="5">
        <location>
            <begin position="61"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="616"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="701"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="domain" description="WDR36/Utp21 C-terminal" evidence="4">
        <location>
            <begin position="836"/>
            <end position="1044"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4041893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1048" mass="114116" checksum="E73783C451D9386D" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PKS4</accession>
    <name>A0AAN6PKS4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinesin light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_15306</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854368">
        <property type="protein sequence ID" value="KAK4040859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PKS4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NLR-like"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
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            <begin position="51"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4040859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="146" mass="16289" checksum="FCB4E39F8D3BCF65" modified="2024-10-02" version="1" fragment="single">LGADHPGTLTSIANLASTYSNQGRWEEAEKLEVQVMETRKTKLGADHPGTLTSMGNLASIYWKQGRWEEAEKLFVQVIEIRKSNLGADHPDTLTSMADLAFTWKGQDRHADALALMEDCAYAQQRVLGSNHPDTRSSFATVVEWRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PKS6</accession>
    <name>A0AAN6PKS6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Major facilitator superfamily transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_44336</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854337">
        <property type="protein sequence ID" value="KAK4042716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PKS6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021822">
        <property type="entry name" value="DUF3405"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36205">
        <property type="entry name" value="CHROMOSOME 19, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36205:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11885">
        <property type="entry name" value="DUF3405"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="731"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="731"/>
            <end position="742"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4042716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="779" mass="87979" checksum="0600A69EBD5EB286" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PKV4</accession>
    <name>A0AAN6PKV4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zinc/iron permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_35092</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854367">
        <property type="protein sequence ID" value="KAK4040919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PKV4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF210">
        <property type="entry name" value="ZINC-REGULATED TRANSPORTER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="378"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="407"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="442"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="476"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="294"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="305"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4040919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="497" mass="54333" checksum="00C2E0FEED8D91B4" modified="2024-10-02" version="1">MDTAAMDNDTRGWIMCAFSGLACIAGASAICIDIPIRLLPGKRHFRIQDSNAFLASSLSLSFGVMLFSALYSMLPSAMRYLAKDEWDEQAAGFVMMSCFIGGFFGIQVISRVLHQYMPSHVVDCDHTHDNLADEELGAHHAHSLPKPSPRPAPADRPHMVELHNGATESTPLIPAEVPRNGHIHTELLNGDAAPAAEAVTHFHGSQRSASTQIRRPSMNVRSRVMSFFKDTKANCDEDGPCYGYSDPCGQECFKHLGTRSALARSGTIPLPLTEGCDDTCEGPIPTPRYRVIRTPSHSHDEHHPDHNHHHHAHAHTHAHDSDLECPEDTEAQHHHHVPTNAFLSIGLQTVIAIALHKFPEGFITYATNHANPSLGFSVFMALFVHNIAEGFAMALPLYMALGSRVRAIFWSSLLGGFSQPLGAAVAVAWFKLAKRSNFEIDSTAYACLFAVTAGIMVSVALQLFVESLSLNHDRNLSIFFAFLGMTLLGISNALVTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PKY9</accession>
    <name>A0AAN6PKY9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">C8A01DRAFT_33028</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="MU854334">
        <property type="protein sequence ID" value="KAK4042924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PKY9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02662">
        <property type="entry name" value="Peptidase_C19F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF888">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="10">
        <location>
            <begin position="153"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="260"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="570"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="671"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="580"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="671"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="750"/>
            <end position="761"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK4042924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="778" mass="85119" checksum="DF71BD7AB5411A83" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PMC8</accession>
    <name>A0AAN6PMC8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mediator of RNA polymerase II transcription subunit 14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Mediator complex subunit 14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">C8A01DRAFT_44423</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Mediator complex subunit 14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854339">
        <property type="protein sequence ID" value="KAK4042538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PMC8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055122">
        <property type="entry name" value="Med14_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013947">
        <property type="entry name" value="Mediator_Med14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12809">
        <property type="entry name" value="MEDIATOR COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12809:SF2">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08638">
        <property type="entry name" value="Med14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26204">
        <property type="entry name" value="Med14_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0010">Activator</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit MED14 N-terminal" evidence="11">
        <location>
            <begin position="77"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1069"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1079"/>
            <end position="1135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK4042538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1151" mass="128947" checksum="4CD75DEC387D4883" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PML8</accession>
    <name>A0AAN6PML8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_33061</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Plays an important role in cellulose degradation. Shows hydrolytic activity against several glycosidic compounds.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="3"/>
    <dbReference type="EMBL" id="MU854335">
        <property type="protein sequence ID" value="KAK4042810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PML8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080079">
        <property type="term" value="F:cellobiose glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000011">
        <property type="entry name" value="Cytosolic beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033132">
        <property type="entry name" value="GH_1_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353:SF36">
        <property type="entry name" value="LP05116P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00653">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00056775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4042810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="503" mass="56583" checksum="76EC0958597F9188" modified="2024-10-02" version="1">MSQEASMFSAADAVVNYGPSSGHEPPVEDLPLPADFAWGTATAAYQIEGGASQDGKGKSIWDTYSHLEPSHTNGENADISCDHYNRMPEDVELMNSLGVDVYRFSISWSRVIPLGGRNDPVNEKGVAFYNGLIDRLLAHGIAPVVTLYHWDAPQEIYNRYGAFLNTEEFRADFERYARLCFTRFGDRVKKWVTFNEPYIISIFAHLNGTLAPGHCREAGTDTKTEPWRVGHTIILSHAAVVDMYAQDFGPSQKGDISIVLNGHFYEPYDAASPADRDAAERRMVFYMGWFADPVLLGTDYPAEMRAYLGARLPEFTADERALLRRTAPINAFYGMNHYSTKYARALSEPPAADDWTGNIEESSVNSEGKETGPVSGLGWLRVAPSGFRKLLNWVWKRYRVPIIITENGCPCPGEDDVVTAVDDKFRQRYLGLYLDAISRAIYEDGVVVKGYYVWSLMDNYEWSAGYSARFGIVHVDFKTLQRTPKNSAYYLRDTFRSRRKAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PMR1</accession>
    <name>A0AAN6PMR1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_31997</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854323">
        <property type="protein sequence ID" value="KAK4043899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PMR1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="171"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4043899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="460" mass="48512" checksum="E4653E935F861CF3" modified="2024-10-02" version="1">MAHVLLGNAAVQAGGINQESFDMGYERGFERGWALGFQNGRQAALLGRATEIEERAGNASAEDGGEAPSNHNPAPGHPEVCLLTDVPVVEDPPDTSPIRDEDVFDDAKSTISAVDSDESDLIDVFYDAKSHISESECGEDNASFSDLLDLSYDDDKSIYEASPISHKSNKSNKSNKSNKSNKTVVGAAVAAAQPESSGAGQMSSSQEGDLLFLDEPTAPIAGETNNDHTTGNTSLVPPQLALLESIPSTSTTDSTGMTPAPEPEDDDTTADPMPSTLYNIPLAHTIRPITPDFSLPPSAKRPRPAYPALADPFNIYTSLAKGLTVSEDPWRVLIGPLSASARAAWSGDKGKGYIRSKLTTGPRVGASMSGSRGGGGYRGGGYRGGHRGGGGGGRGWNHAQADETPSCGLVFCDMISDEEGVRYIVATFETQEKAREAVGVFTGYACGGSIMWAWIYQEQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PMW8</accession>
    <name>A0AAN6PMW8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_14247</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854346">
        <property type="protein sequence ID" value="KAK4042059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PMW8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11387">
        <property type="entry name" value="bHLHzip_USF_MITF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051732">
        <property type="entry name" value="USF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46117">
        <property type="entry name" value="FI24210P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46117:SF3">
        <property type="entry name" value="FI24210P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="6">
        <location>
            <begin position="279"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="205"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="263"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="322"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="174"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="226"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="341"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4042059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="520" mass="55486" checksum="D906EFEB72285C10" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PNK0</accession>
    <name>A0AAN6PNK0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Acyl-CoA desaturase</fullName>
            <ecNumber evidence="16">1.14.19.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">C8A01DRAFT_13101</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:19721"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:57394"/>
            <dbReference type="EC" id="1.14.19.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="16">Expected to bind 2 Fe(2+) ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.1" evidence="16"/>
    <dbReference type="EMBL" id="MU854328">
        <property type="protein sequence ID" value="KAK4043335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PNK0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004768">
        <property type="term" value="F:stearoyl-CoA 9-desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006636">
        <property type="term" value="P:unsaturated fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03505">
        <property type="entry name" value="Delta9-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000004">
        <property type="entry name" value="Acyl-CoA desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009160">
        <property type="entry name" value="Acyl-CoA_deSatase_haem/ster-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015876">
        <property type="entry name" value="Acyl-CoA_DS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351">
        <property type="entry name" value="ACYL-COA DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351:SF31">
        <property type="entry name" value="DESATURASE 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000345">
        <property type="entry name" value="OLE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00075">
        <property type="entry name" value="FACDDSATRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0249">Electron transport</keyword>
    <keyword evidence="15 16" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="8 16" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 16" id="KW-0349">Heme</keyword>
    <keyword evidence="12 16" id="KW-0408">Iron</keyword>
    <keyword evidence="4 16" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="13 16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 16" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="199"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="19">
        <location>
            <begin position="348"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR000345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAK4043335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="475" mass="53600" checksum="679D6C046855D13A" modified="2024-10-02" version="1">MASSSSEVPVAQAETFPDGTTDHVPLRKRNYDIRKPHITEQPITWANWYQHVNWLNTYFIIVVPLVGLISSYWINLQYKTAIFAVAYYFFAGLGITAGYHRLWAHSSYKASLPLKIFLAAGGAAAVEGSARWWSSLHRSHHRYTDTEKDPYSVRKGLLYSHIGWMVMKQNPRRIGRTDITDLNDDAVVVWQHRNYLKSVVTMALLVPTLVCGLGWGDFLGGFVYAGILRIFFIQQATFCVNSLAHWLGDQPFDDRNSPRDHVITALVTLGEGYHNFHHEFPSDFRNAIEWWQYDPTKWFIWTMKQLGLAYNLKTFPQNEIEKGRVQQLQKKLDQKRSTLDWGIPLESLPVVSWDDFVEQSKNGKAWIAVAGVIHDVGKFIADHPGGKALISSAVGKDATAVFNGGVYNHSNAAHNLLSTMRVGVLRGGCEVEIWKRAQSENKDVNAITDSSGQRIVRAGDQLTRIGRPITTADTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PP05</accession>
    <name>A0AAN6PP05_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytochrome P450 monooxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_12344</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854320">
        <property type="protein sequence ID" value="KAK4044277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PP05"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11059">
        <property type="entry name" value="CYP_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="480"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4044277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="535" mass="60224" checksum="14296E89CC709E92" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PQZ8</accession>
    <name>A0AAN6PQZ8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PLC-like phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_12025</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854317">
        <property type="protein sequence ID" value="KAK4044625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PQZ8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF80">
        <property type="entry name" value="PLC-LIKE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26146">
        <property type="entry name" value="PI-PLC_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042911585" evidence="2">
        <location>
            <begin position="22"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4044625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="416" mass="44584" checksum="8B58B13B704B13C8" modified="2024-10-02" version="1">MARLPPRALTALLSLTPRVLASPQDRAMTTTATQPAPSTAAAPVPCNNSPDLCSRAYNNITHMGAHDSAFLRDASTSNSVAGNQYYNATIALSAGIRLLQAQVHLSSNNTLELCHTDCRILDAGPLEAWLARIKHWLDANPNDVVTLLLVNSDNQPASSFGTVFDRSGISTYAYTPPSSSGSNQNTITWPTLQALITANTRLITFIASLPSPTTSDYPYLLNEFNHVFETPYNTTSPSSFTCALDRGGNSTSVQTAISAGMLPLLNHFVYLELTPDIWIPAASAVDATNSPSETEVGALGRHLRDCMGEWGNNARVVFVLVDFYDRGPAVGAADRVNGVGEAVGRVREPAVASSRAVRVRGRRRFFGGGAEVVVGVLLGMGWATVVFQERVGVGYWVCLFFAVLGDYLDMEGGREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PR52</accession>
    <name>A0AAN6PR52_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-dependent DNA ligase family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_12956</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854327">
        <property type="protein sequence ID" value="KAK4043441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PR52"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032807">
        <property type="term" value="C:DNA ligase IV complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08039">
        <property type="entry name" value="Adenylation_DNA_ligase_Fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="entry name" value="DNA ligase, ATP-dependent, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029710">
        <property type="entry name" value="LIG4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45997:SF2">
        <property type="entry name" value="ATP DEPENDENT DNA LIGASE DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G02430)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45997">
        <property type="entry name" value="DNA LIGASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-dependent DNA ligase family profile" evidence="7">
        <location>
            <begin position="382"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="665"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="815"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="665"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="780"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="819"/>
            <end position="834"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4043441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1001" mass="111460" checksum="0DC32A6D64B9286B" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PSU1</accession>
    <name>A0AAN6PSU1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_32029</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854323">
        <property type="protein sequence ID" value="KAK4043930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PSU1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4043930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="51" mass="5783" checksum="8FE9D37990F31F02" modified="2024-10-02" version="1">MKKKTQKELDEELRLKMEGLSGDGGASGVEYEDGKAVAMKRSVKENMFRYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PTG1</accession>
    <name>A0AAN6PTG1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">General alpha-glucoside permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_31340</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854318">
        <property type="protein sequence ID" value="KAK4044551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PTG1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008506">
        <property type="term" value="F:sucrose:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19432">
        <property type="entry name" value="SUGAR TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19432:SF76">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13347">
        <property type="entry name" value="MFS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="377"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="430"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="456"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="559"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="604"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="12"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4044551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="629" mass="67737" checksum="2908576EC703743E" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SKQ7</accession>
    <name>A0AAN6SKQ7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Oxidoreductase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">C8A01DRAFT_51109</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854665">
        <property type="protein sequence ID" value="KAK4031991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SKQ7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12163">
        <property type="entry name" value="2-Hacid_dh_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11063">
        <property type="entry name" value="CYP52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047146">
        <property type="entry name" value="Cyt_P450_E_CYP52_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287:SF1">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042866485" evidence="9">
        <location>
            <begin position="20"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="10">
        <location>
            <begin position="616"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="10">
        <location>
            <begin position="714"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="447"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK4031991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="867" mass="97142" checksum="2E33456422814A17" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SKW0</accession>
    <name>A0AAN6SKW0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">chitinase</fullName>
            <ecNumber evidence="4">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">C8A01DRAFT_51522</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="4"/>
    <dbReference type="EMBL" id="MU854838">
        <property type="protein sequence ID" value="KAK4031379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SKW0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00035">
        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.10">
        <property type="entry name" value="Endochitinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001002">
        <property type="entry name" value="Chitin-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018371">
        <property type="entry name" value="Chitin-binding_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036861">
        <property type="entry name" value="Endochitinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF333">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00187">
        <property type="entry name" value="Chitin_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00270">
        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57016">
        <property type="entry name" value="Plant lectins/antimicrobial peptides"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00026">
        <property type="entry name" value="CHIT_BIND_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50941">
        <property type="entry name" value="CHIT_BIND_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="6 12" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 13 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042957973" description="chitinase" evidence="14">
        <location>
            <begin position="24"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-1" evidence="15">
        <location>
            <begin position="60"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="16">
        <location>
            <begin position="114"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="77"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="82"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAK4031379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="491" mass="53912" checksum="E3948EDCDBE9E31F" modified="2024-10-02" version="1">MLTRPSVLLLGGLLILLISPILAQSTPDYTCSRTKPCTLVCGMGPTFCAPGNCTSECNAKSECDPGWGLEWSQATNCPLNVCCSKFGFCGTSAEFCDGKTVPSPNCPGGKSADQRTIGYYEGWNLGRSCGRMAPEDIPLGYYTHINFAFALVNPQTFAIEDMGPDTAALYDRVSALKSRDPNLKVWIAVGGWAMNDPGPYRTTFSDLAKSTAAQDAFFESLITFMRRHNFDGVDLDWEYPVADDRGGIAADHDNFVTLVRRLRERLNQTGKDYGITITLPASYWYLRGFNLQGLEPFLDWFNVMTYDIHGTWDSTVKAIGPYAFAHTNMTEIQQALELLWRNNINPGRVVLGLGFYGRSFTMKSPDCMHAGCEFTDGARGGECTGTPGVLSASEINTIIAKGATVTMDEEAAVKIVTWDSNQWVSYDDAVTLKKKLDYANLRCLGGTMVWAIDLDDGTLINALGSDLSRPKSTLTKRPVVLPDFETGWDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SL18</accession>
    <name>A0AAN6SL18_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_41236</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854622">
        <property type="protein sequence ID" value="KAK4032336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SL18"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05120">
        <property type="entry name" value="APH_ChoK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF48">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="31"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4032336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="291" mass="33900" checksum="F7C74C7AF65810C5" modified="2024-10-02" version="1">MAARPRLPYFAPAELLPAPLPTVAEILASTTRLSKEYEKSVFRVGEHFAVKFGDGVHLQEGENMLFVQQSTSIPVPKVYALFHDKEIEMDFIVQEYIPGRDLDPVWETLATTEKQAVVSQLHRYLGELRSIPSPGYYGGIWKQPIRDFHFTNGNPGHQPYQDTAISGPHETEEQWVEAMWRCIDTRTETPTGRRMMSLVRRHYHAVFKGHESVFTHGNILPRNLILRDDGTVVIIDWERAGWYPSFWEYCCTVMLLKYIDDWGEWIPEMLDDEYHSELGWLSHHRNTVMFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SLJ2</accession>
    <name>A0AAN6SLJ2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_21053</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854702">
        <property type="protein sequence ID" value="KAK4031782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SLJ2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF5">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="476"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4031782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="554" mass="62385" checksum="E5909007EF35213E" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SLL1</accession>
    <name>A0AAN6SLL1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">superoxide dismutase</fullName>
            <ecNumber evidence="4">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_21003</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell envelope</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Cu-Zn superoxide dismutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="4"/>
    <dbReference type="EMBL" id="MU854692">
        <property type="protein sequence ID" value="KAK4031843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SLL1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.200:FF:000007">
        <property type="entry name" value="Cell surface Cu-only superoxide dismutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="entry name" value="Superoxide dismutase, copper/zinc binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053257">
        <property type="entry name" value="Cu-only_SOD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20910">
        <property type="entry name" value="AGAP001623-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20910:SF1">
        <property type="entry name" value="SUPEROXIDE DISMUTASE COPPER_ZINC BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="Cu,Zn superoxide dismutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042955397" description="superoxide dismutase" evidence="8">
        <location>
            <begin position="19"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4031843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="195" mass="20217" checksum="9A450EE47F176E90" modified="2024-10-02" version="1">MHTLSLLAALVAAQGAVAQMTGKLGDAMAVMNNPPGASYVAMFTEGSGNPVRGKVSAMSSPGGKSVTFNLMLMGLPMGGGPYSYHLHDQPVPVDGNCAATLAHLDPYQRGQAVPCDMSMPETCEVGDLSGKHGKIEGPEVSKSFMDMYVALVPGIGAFFGNRSIVIHYANSTRLACANFTMEKMPGSGCGMGGPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SLQ6</accession>
    <name>A0AAN6SLQ6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_19972</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854557">
        <property type="protein sequence ID" value="KAK4033026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SLQ6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="464"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="464"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4033026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="571" mass="61154" checksum="81A00B881EBCFD33" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SMB2</accession>
    <name>A0AAN6SMB2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SMODS and SLOG-associating 2TM effector domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_50682</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854597">
        <property type="protein sequence ID" value="KAK4032548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SMB2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041622">
        <property type="entry name" value="SLATT_fungi"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF033635">
        <property type="entry name" value="SLATT_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38793">
        <property type="entry name" value="SLATT_FUNGAL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38793:SF3">
        <property type="entry name" value="SMODS AND SLOG-ASSOCIATING 2TM EFFECTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18142">
        <property type="entry name" value="SLATT_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="SMODS and SLOG-associating 2TM effector" evidence="3">
        <location>
            <begin position="129"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4032548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="292" mass="31092" checksum="6DECCF1971A09DA8" modified="2024-10-02" version="1">MSAPPVTSPNPKSPAQFHAAELSPPAPDTDPSVGAGSTIVGGSGGGGAPDPDHPDHPDQKIGLGLRGPVKADTDLSWGAPAGLHIRRLNDENLVIFRRAVGINSTLSGSTDPESLEAGRRKAVGIYAAALSEVRRKKWMYHILSFVINASHFAQIIIGASLTALGPSAGDHVIAITLLGAVNTVIAGVLALIKGQGLPDRLYHDRAEYRRLQDWIEQTEALLAVGVIGRDRKEVGVLVQSAFRKYNAAKRCEESNLPENYVRPPDPEQNGRPVSQGSQNTPSHLVRSPSPYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SMF9</accession>
    <name>A0AAN6SMF9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Gfo/Idh/MocA-like oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_40877</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854584">
        <property type="protein sequence ID" value="KAK4032683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SMF9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051450">
        <property type="entry name" value="Gfo/Idh/MocA_Oxidoreductases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43377">
        <property type="entry name" value="BILIVERDIN REDUCTASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43377:SF12">
        <property type="entry name" value="BINDING ROSSMANN FOLD OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11840)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="1">
        <location>
            <begin position="18"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4032683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="533" mass="58643" checksum="30B6FCBD1F217307" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SMI8</accession>
    <name>A0AAN6SMI8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_20219</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854578">
        <property type="protein sequence ID" value="KAK4032758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SMI8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4032758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="135" mass="15137" checksum="801B0B8C7EA659AD" modified="2024-10-02" version="1">MENTPTSITIPEQRHRAAVQPEAGSSPSSYSSSPSSPEPSSKTPSRKQKLLHARRPSLLSSAFTQQECTTIKIGDDPEGPMRLVTYLASGQGFVWNPEIFVPSFCDYDYVPLEQRRDPVHEIYLSDEEIKKMLPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SND2</accession>
    <name>A0AAN6SND2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_39894</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the indoleamine 2,3-dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854518">
        <property type="protein sequence ID" value="KAK4033628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SND2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000898">
        <property type="entry name" value="Indolamine_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037217">
        <property type="entry name" value="Trp/Indoleamine_2_3_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657:SF3">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01231">
        <property type="entry name" value="IDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140959">
        <property type="entry name" value="Indolic compounds 2,3-dioxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4033628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="284" mass="30914" checksum="A2308E14DB1A3E5A" modified="2024-10-02" version="1" fragment="single">MGSLGHTLPPFTVLDDTRPDDMSLPAFMVSTTRGFLPRMDPIVALPAEFDALESLLQRMPVKTLSGDPGLLADGKLGEAVAQELPDLTDAVDKYKANLPLMNALYRDYSFLASAYLLEPCHERFVRGEGYGLGRDVLPANIARPIAKCAALCDFKPFMEYAGSYALFNYRLVDPSLGLASSNLRLIRAFEHGLDPSSSEAGFVLVHIEMVKHSGALVAGAVACLKACTASHSPPPSPARQELNTALHTVLTSLQKVNATMETMWTRSRPTQYTSFRTFIFGITS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SNU9</accession>
    <name>A0AAN6SNU9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_49360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854490">
        <property type="protein sequence ID" value="KAK4034197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SNU9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025040">
        <property type="entry name" value="DUF3984"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13136">
        <property type="entry name" value="DUF3984"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4034197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="392" mass="43233" checksum="879AE7C0BD0C8CBF" modified="2024-10-02" version="1">MDAPSSRRKNRSAANLDHLSLAPLTTRLPLHREDYDAISSASPRPHTSYIEPKSAPTTPRLLSHSPPPRPRRPARGASVPYAQKSKSSTHLAKNGNNSRTRNSTAATAPASRRDTSFFPDTDFLFRVGSVIASETREAKGQSWLVTRASSTASLPVEREGYYAAERDADARRQVGASGSNSRRGSRDDYAYASPYSAFASPVQSRFGSRAQSRRSSRVMTPAEMRRAELLVRLEDDPRVAEDYFGRMAAPTSEDGTPIAAPAFVGLNERLEFGEDEDEDEGCTSEDEAYIRRLARERGFLGSLLDKLTGGGLAELAGDDEESEPEEDGGKDDFEAWKDEEQQRQERRSASLRRLQECTVIPLDCTNDPPPQEDKGGWSDASWLLKVAAKAFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SNZ0</accession>
    <name>A0AAN6SNZ0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_19020</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854494">
        <property type="protein sequence ID" value="KAK4034125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SNZ0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053007">
        <property type="entry name" value="CYP450_monoxygenase_sec-met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47582">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47582:SF1">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="4 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="3 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4034125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="237" mass="25831" checksum="191E7359EB40F1AA" modified="2024-10-02" version="1">MVWFVFSSAKAGGLVERLRREVQEGLVLGRGADETVEGGEGEVVRLGVAVARVEERCPLLMACYREAQRFTVHQVSTRVAMKDTVLSGKEGKEYLLKEGAVVQLVIGVGHAMREYWGEDVGEFRPERFLGLNEGRKGEGADGPGSARAMRAAFQPFGGGLHLCPGRQFAFAELMAVMGTLLLGFEVEPLEGADWNLPGFATRSLVDAVTKPANNGEGFGVKVTRRPGWEGVRWSYEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SP40</accession>
    <name>A0AAN6SP40_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EKC/KEOPS complex subunit BUD32</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">Atypical Serine/threonine protein kinase BUD32</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">EKC/KEOPS complex subunit bud32</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">C8A01DRAFT_49217</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. BUD32 has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit KAE1. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="MU854482">
        <property type="protein sequence ID" value="KAK4034363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SP40"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050167">
        <property type="entry name" value="Ser_Thr_protein_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23257">
        <property type="entry name" value="SERINE-THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="1"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK4034363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="242" mass="26269" checksum="98D4BE5642869C5D" modified="2024-10-02" version="1">MSDSADDEIRYPSGFGLGDVVSWGTTGMVVLDKTSNTVIKVPFDHGNQACLLRMQREHDVYERLAQMGGHEGLLAYHGVVDSGIRLEYAPGHNLRLQLEDRDRALGFIYNAGVIHGDLTCANIFMDANLNARVADFAGSSVDASPLLVVVTESHESPGPRLSIQADLFALGSVLHEITTGHPPYKDLDATEIRSLYVERKFPETASLGAIGVIIEQCWQGNYSGAGAVVEDLEVIVSIVMRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SP84</accession>
    <name>A0AAN6SP84_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Rhamnose mutarotase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_18693</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854476">
        <property type="protein sequence ID" value="KAK4034528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SP84"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016857">
        <property type="term" value="F:racemase and epimerase activity, acting on carbohydrates and derivatives"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008000">
        <property type="entry name" value="Rham/fucose_mutarotase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34389">
        <property type="entry name" value="L-RHAMNOSE MUTAROTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34389:SF2">
        <property type="entry name" value="L-RHAMNOSE MUTAROTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05336">
        <property type="entry name" value="rhaM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4034528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="123" mass="14415" checksum="E2A5EFE441A5FE01" modified="2024-10-02" version="1">MDSKVGNPARRFAQIVKLKPEFLERYKEVHAAVWPEVLKQIADCNIVDYSIFHDAETGILFASFKYVGHDYAGDMERMRENPKVREWWRMTDGWQESMVPGAKDSESGEPSWWKPVEEVFYTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SP88</accession>
    <name>A0AAN6SP88_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosomal protein L11 methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_39037</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854478">
        <property type="protein sequence ID" value="KAK4034470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SP88"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010420">
        <property type="term" value="F:polyprenyldihydroxybenzoate methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464:SF89">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="1">
        <location>
            <begin position="60"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4034470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="279" mass="31070" checksum="EF19BCBC0AF44235" modified="2024-10-02" version="1">MPTEPPSLSARAVATWEANAAHWDSTITAHGNKYWRRLQEPSLTRLLTPSFIKHPECKALDLATGNGLCARWLTRNGARSVLATDASENMLALARGHCEDGTEQEKGVRFRRVDVTSREDLEALAEEEGRFDVVLMNMAIMDVAELGPLVYALKGLLAEGGVFVATLLHPVFFTSNAARNIEVRFDPVTGECEVVRGKMVREYMSVPPAMGIAVPGQPVKQPYFHRPMHELFTSFFRAGLVMDAMEELAFTEEDAEDRIESSSNYTQLPAILSFRMRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SPX3</accession>
    <name>A0AAN6SPX3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 8">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="7 8">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">C8A01DRAFT_38135</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the PPP phosphatase family. PP-Z subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="7 8"/>
    <dbReference type="EMBL" id="MU854445">
        <property type="protein sequence ID" value="KAK4035397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SPX3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07414">
        <property type="entry name" value="MPP_PP1_PPKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000006">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011159">
        <property type="entry name" value="PPPtase_PPZ/Ppq1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031675">
        <property type="entry name" value="STPPase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF484">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE PP-Z1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16891">
        <property type="entry name" value="STPPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000909">
        <property type="entry name" value="PPPtase_PPZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="10">
        <location>
            <begin position="322"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="94"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK4035397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="532" mass="57688" checksum="0FF2F7C0EFECE012" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SQ11</accession>
    <name>A0AAN6SQ11_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SUR7/PalI family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_17921</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854445">
        <property type="protein sequence ID" value="KAK4035398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SQ11"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051285">
        <property type="term" value="C:cell cortex of cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052413">
        <property type="entry name" value="SUR7_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28019">
        <property type="entry name" value="CELL MEMBRANE PROTEIN YLR413W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28019:SF3">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_6G07470)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="219"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="264"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4035398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="351" mass="37420" checksum="74C8AD863ED23427" modified="2024-10-02" version="1">MANFGRFVCVLVPFLLTLASLVAMLIAGLAGIADKSLYMFRVNVTDLSISPLSVSGILNGTGLNIPTSLDDINVDVPNVDIPDIDIPDIDIPDVDISVGKRQTQTTNITAADLGLYDVYDVNMWNYCYTKQDGTRECTKGAFDWAAHALNTTTGDFNSMLTSTGLNVTLPSGITDAVKAFGTVSKWTQVVFIIASVTLGVELFFGLFANCSRAFSCVTWLIAFLAILATGAAAALATATSVIVVGAVEASSELYGIDAQLNTRFLAAVWISVAFAIAAGLFWMFTICCCKPDHSSRRSRSRHGDEAEKFIPAGNGGSGYSRLGEPSGYARQSYGPAQQHSGAYEPYSHARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SQD7</accession>
    <name>A0AAN6SQD7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CN hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_37857</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854436">
        <property type="protein sequence ID" value="KAK4038213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SQD7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07197">
        <property type="entry name" value="nitrilase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050345">
        <property type="entry name" value="Aliph_Amidase/BUP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43674:SF16">
        <property type="entry name" value="CARBON-NITROGEN FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G02350)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43674">
        <property type="entry name" value="NITRILASE C965.09-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="2">
        <location>
            <begin position="5"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4038213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="309" mass="34048" checksum="0F087637C19A0262" modified="2024-10-02" version="1">MAPIYKIAIIQLQPEDVAVEDNFTRAESFIRQAAAQGAHLAVLPEYHLTSWCPDHPDFIAACAESATYLPRYQALARDLHINIVPGTICEVHPASSDSTSEEKEIRNMAYWIDASTGSLLASYQKLNLWHSERPHLTAGSSLSHTPHRAFDTPLTWGPDQNGRPIRAGMLICWDLAFPEAFRALVRDGAELIVIPSYWVSDGSDLDEARKRMNAGCEGLFIDSVLVARAFESECVVVFCNAPGLSQVVAPVFGRVGGEGMGRNVEGMRVVEVDFEGGVVLEREYKIRGDLRGEGWHYGYELGAEGEKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SQH9</accession>
    <name>A0AAN6SQH9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">lytic cellulose monooxygenase (C4-dehydrogenating)</fullName>
            <ecNumber evidence="15">1.14.99.56</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">C8A01DRAFT_16634</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the polysaccharide monooxygenase AA9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="15"/>
    <dbReference type="EMBL" id="MU854402">
        <property type="protein sequence ID" value="KAK4039364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SQH9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF19">
        <property type="entry name" value="GLYCOSYLHYDROLASE FAMILY 61-8 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042975050" description="lytic cellulose monooxygenase (C4-dehydrogenating)" evidence="16">
        <location>
            <begin position="20"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="17">
        <location>
            <begin position="18"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAK4039364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="239" mass="25554" checksum="7153D6FADC033018" modified="2024-10-02" version="1">MRFDALAALALAPLVAGHGAVTSYIIGGTTYPGYEGFSPASSPKTIQFQWPDYNPTMTVGDPKIRCNGGTSADLSAPVTAGQNVTAVWKQWTHAQGPVMVWLFKCPGDFGSCKGDGQGWFKIDQMGMWGNNPNSENWGTAIVLKTLKWSSMIPTNLAPGNYLIRHELLALHQANTPQFYAECAQIVVSGSGTAAPPSDKLFSIPTYAPQTDPGITVDIYQGGLTSYTPPGGDVWSGFQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SQP8</accession>
    <name>A0AAN6SQP8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_47410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854411">
        <property type="protein sequence ID" value="KAK4039082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SQP8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF284">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="1">
        <location>
            <begin position="42"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4039082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="475" mass="51412" checksum="8ACF817BE820D172" modified="2024-10-02" version="1">MDERAQIPVSLPRANPTVSYWQDPPDALADYCSTPDLPSTADTIIIGSGITGAAVAWNLLQGPNPGSILMLEARQACSGATGRNGGHTKAASYRTFPHHVQSHGLPTAKQIARLELRNIQAVHAFARAHAIACDLNPCDTLDVIYDPAQWDQAVAAVAAMRDAFPGGGGGQPEPEGEGEYELYSAEEVRARFHEEKVQGGVGYFAGSLSAYKFGVGVLRLCVERGLNLQTGTAVTGLSKTEDGGGLWEVKTARGTVRAKRVVLATNGYTAGIWKRFQGVVVPLRGQVTAQRPGRGMPGKGCLERTYSFIYEKGYEYMVSRPEGSRFAGDIVMGGGLVRAPDDGLMEFGTTDDSTVNEEISEYLRETTGRYFGPDWGEDDPEGRVRSEWTGIMGFSPDGFPLVGEVPGEQGLWASCSFQGHGMVLCWMCARALVEMMEGGDGEDLREWFPDAFRITEARLAQRFQGRLDAIPKTDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SRJ6</accession>
    <name>A0AAN6SRJ6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_36303</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854394">
        <property type="protein sequence ID" value="KAK4039680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SRJ6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034067">
        <property type="term" value="P:protein localization to Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001317">
        <property type="entry name" value="Putative ADP-ribosylation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45909">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45909:SF1">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="143"/>
            <end position="146"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4039680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="212" mass="23625" checksum="56EAF4EF228FA0CD" modified="2024-10-02" version="1">MYHLAKGLYRLATSKEEYSVLLLGLDNAGKTTFHEQVKATFLPDGPAPNLKTVPTVGQNVSTIVLPDMYLKLWDVGGQLSLRQLWQSYYASCHAIVFIIDSTDIGDGSLDRDSTGRLEECRLVLEDVLQNSEAEGVPLLILANKQDREDCVEVVRIKEGLVKRVFEGEKAGGIRDSRVLPVSALTGTGVKEAVDWVRSRVRWNKESRPPLMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SRM9</accession>
    <name>A0AAN6SRM9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_35356</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854373">
        <property type="protein sequence ID" value="KAK4040594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SRM9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042994844" evidence="1">
        <location>
            <begin position="23"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4040594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="155" mass="17247" checksum="48D431CB20F31963" modified="2024-10-02" version="1">MLSHRWSKHLSLAVLGLACTHAAVTVQAQSSSNLSSRSFAARATVLGKYVYIDGGVTLTEEMMGKEEEPSPSFWMFSIDISKSWSTDQDPRERKFYPDDAQPILARASHTLWTDDDEGAFYSWGGEYPSDMEGIKNELWKFTADARGGGTWILAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SRS6</accession>
    <name>A0AAN6SRS6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1996 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_16332</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854393">
        <property type="protein sequence ID" value="KAK4039741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SRS6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018535">
        <property type="entry name" value="DUF1996"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662:SF6">
        <property type="entry name" value="DUF1996 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09362">
        <property type="entry name" value="DUF1996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042990533" description="DUF1996 domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1996" evidence="2">
        <location>
            <begin position="57"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4039741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="368" mass="40664" checksum="209BFF864D4EC820" modified="2024-10-02" version="1">MVWSYLLANLALAALAAAQYYEGYEGDEPMLRGQRPRTNPSAMLRFGCSQVVIERLDPLVDPGMAPSSHMHQVVGGDAFAASMPATDISKLGSCTTCHFKEDISNYWTANLYFRARNGSYKRVPQIANQFNDGDNAGITIYYTSPGPNLTTAFKPGFRMLTGDSTQRQSDNFGKKMQQCYRCFTAENWGGSMYSPCMDPQFDTDYFPKQPCVGGIRSNIIFPLCWDGKNLDTPNHKDHVAHPVGGPTSFAVVSGECPSSHPVKIPQVMLEVMWDTRGFNDPEDWPEDGSQPFYLSNGDHTGFGQHGDYVFGWEGASLQRAMDSACYLWNCSLLSPMPPKVKNLCQVPVTVKEELDAWLDELPGGGKGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SRW5</accession>
    <name>A0AAN6SRW5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heterokaryon incompatibility protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_45871</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854368">
        <property type="protein sequence ID" value="KAK4040849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SRW5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26639">
        <property type="entry name" value="Het-6_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="44"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4040849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="637" mass="71980" checksum="B0F60CA78808A990" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SS91</accession>
    <name>A0AAN6SS91_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_15947</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854383">
        <property type="protein sequence ID" value="KAK4040133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SS91"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4040133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="266" mass="29363" checksum="9D354346463FC174" modified="2024-10-02" version="1">MLTDLGTEGKLASLPPHLLRAYQDPASVLAWNQDQNQPDPNQANLIQAGEGPASQLPAPSQPAPPAPGWEDPAAHHLKQLYYNWRPRMAELMQLSSGHRNRFDGRHVETRVNWAIPVNLVHVDPGRGARHTWMQKTIADLALRADRLMQLSSLRWEFQFTEPNGPGAGPTSGFAYDDSQGCMDLHWLQWDQQPRAPGRAVDHVVRPLLRCYTLDPDARRWDKLLHVRPMQVCMHGKGRKVPVPAPVAGGNPANAGNAGNSGNAGNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SSA5</accession>
    <name>A0AAN6SSA5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_46349</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854380">
        <property type="protein sequence ID" value="KAK4040281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SSA5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4040281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="182" mass="20666" checksum="37E71FA326D506AE" modified="2024-10-02" version="1">MADGLNEYRTARVAELLADFRTLQYYIAAVPCNPADMDDYYTEGWAALRQCAIDGQHILNCAADVTVPCASGGPDEQAKAELRQVLLDAYARRHEGQKIYLRQAAAQRWVDWRDQILMGGRPHSGNQQQLRLVDQQLRAELANIADEVVYSELQASDMTIGRWTAEDPSLRAVQRWVRTRRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SSV4</accession>
    <name>A0AAN6SSV4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_15353</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854369">
        <property type="protein sequence ID" value="KAK4040793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SSV4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:RNA nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.30">
        <property type="entry name" value="Microbial ribonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016191">
        <property type="entry name" value="Ribonuclease/ribotoxin"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53933">
        <property type="entry name" value="Microbial ribonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="109"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4040793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="164" mass="18387" checksum="A2D5D4F576F9707A" modified="2024-10-02" version="1" fragment="single">RIPAKSVREQVQAAPWRLPARGYPKSHKGFEHRGNVYTLRAEPPWVEFPILNTRDGCGWRGDQSPGPVRAIYNDDDRGTFDVVYHDPTAERRGKHHGFTMAIYRPATRWNGTRSGNTRRSGSMGNSTEWPSLGQGVVGGQKPSGACKVEIRHTYQRTVTFVGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6ST17</accession>
    <name>A0AAN6ST17_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Actin cytoskeleton-regulatory complex protein PAN1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">C8A01DRAFT_45699</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the PAN1 actin cytoskeleton-regulatory complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Actin patch</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PAN1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854364">
        <property type="protein sequence ID" value="KAK4041061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00052">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000349">
        <property type="entry name" value="Actin cytoskeleton-regulatory complex protein PAN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000261">
        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216:SF173">
        <property type="entry name" value="ACTIN CYTOSKELETON-REGULATORY COMPLEX PROTEIN PAN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216">
        <property type="entry name" value="EH DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12763">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00027">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50031">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11 16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="10" id="KW-0967">Endosome</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EH" evidence="18">
        <location>
            <begin position="178"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="EH" evidence="18">
        <location>
            <begin position="441"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="19">
        <location>
            <begin position="474"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="597"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="782"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="862"/>
            <end position="1439"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="688"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="92"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="120"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="782"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="899"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="962"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1023"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1107"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="1138"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1154"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="1176"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="1220"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1263"/>
            <end position="1273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="1274"/>
            <end position="1284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1316"/>
            <end position="1326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="1327"/>
            <end position="1355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="1364"/>
            <end position="1378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="1385"/>
            <end position="1397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00025194"/>
        </source>
    </evidence>
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            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK4041061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="22">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1439" mass="155044" checksum="47230CC6C1BD114E" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6ST50</accession>
    <name>A0AAN6ST50_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_14895</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854359">
        <property type="protein sequence ID" value="KAK4041330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23242">
        <property type="entry name" value="TRANSCRIPTION FACTOR HOXA13"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TRANSCRIPTION FACTOR HOXA13"/>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="274"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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            <end position="702"/>
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            <begin position="745"/>
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            <end position="401"/>
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            <begin position="756"/>
            <end position="787"/>
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    <evidence type="ECO:0000256" key="1">
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        <source>
            <dbReference type="EMBL" id="KAK4041330.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1205" mass="128115" checksum="4B4BC2205FC6B059" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6STA3</accession>
    <name>A0AAN6STA3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_44607</name>
    </gene>
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        <name type="scientific">Parachaetomium inaequale</name>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854342">
        <property type="protein sequence ID" value="KAK4042349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6STA3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Acetyltransferase_Butenolide"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43233">
        <property type="entry name" value="FAMILY N-ACETYLTRANSFERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03350)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43233:SF1">
        <property type="entry name" value="FAMILY N-ACETYLTRANSFERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03350)-RELATED"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="105"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4042349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="213" mass="22809" checksum="C6702747132862B8" modified="2024-10-02" version="1">MPPPNPPQTWTRQVSGTTYTVSTDRSLIQLDALNAAFASDMLYWAKPLAPDVLQLCVEQSLCFGLYAHGEGQEGSPQPQEGGDGGGADSIATKQGAEKTPPPPMVGFARLVTDHTTFAYLTDVYVLPPHQGRGLGRWMMGCLDETLEKWQDLRRCLLLTRDAAAVRMYGATIGAREMRQASSSGGLFVLERVGRGGVSFTGGSTEEADEGGAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6STC7</accession>
    <name>A0AAN6STC7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Small nuclear ribonucleoprotein G</fullName>
            <shortName evidence="9">snRNP-G</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">C8A01DRAFT_34093</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Plays a role in pre-mRNA splicing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854350">
        <property type="protein sequence ID" value="KAK4041842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6STC7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034719">
        <property type="term" value="C:SMN-Sm protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097526">
        <property type="term" value="C:spliceosomal tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01719">
        <property type="entry name" value="Sm_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000019">
        <property type="entry name" value="Small nuclear ribonucleoprotein G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044641">
        <property type="entry name" value="Lsm7/SmG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034098">
        <property type="entry name" value="Sm_G"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553:SF2">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037188">
        <property type="entry name" value="U6_snRNA_Lsm7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="3"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK4041842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="83" mass="9200" checksum="050B0D3AEBAAF33F" modified="2024-10-02" version="1">MAPAQPELKKYLDKRLFVQLNGSRKVIGVLRGYDVFLNIVLDDAVEEKDNGEKAKLGMVVIRGNSVVMLEALERIGGDERGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6STI4</accession>
    <name>A0AAN6STI4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Emp24/gp25L/p24 family/GOLD-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">C8A01DRAFT_44459</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854339">
        <property type="protein sequence ID" value="KAK4042574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6STI4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042951742" evidence="10">
        <location>
            <begin position="23"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="11">
        <location>
            <begin position="32"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK4042574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="204" mass="23267" checksum="C1741A3F420399A1" modified="2024-10-02" version="1">MFLQTAAKLLLSASLLLGSAVAHNIQLPAHGRECFHENLHHGDKMTVTFQVGDREFGSAGNLDIDFWITNPMGQYEANDKSVSNGDFSFDAKHDGKYLYCFGNEHWGASSKEVSFNVHGIVYVSEADAPQDPLEAEVRKLSELLERVKDEQGYIVVRERTHRNTAESTNSRVKWWNLFVIGVVFGESVFQVWWLRRFFEVKRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6STX5</accession>
    <name>A0AAN6STX5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CBF1-interacting co-repressor CIR N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_44897</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854347">
        <property type="protein sequence ID" value="KAK4042006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6STX5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019339">
        <property type="entry name" value="CIR_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039875">
        <property type="entry name" value="LENG1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22093">
        <property type="entry name" value="LEUKOCYTE RECEPTOR CLUSTER LRC MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22093:SF0">
        <property type="entry name" value="LEUKOCYTE RECEPTOR CLUSTER MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10197">
        <property type="entry name" value="Cir_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01083">
        <property type="entry name" value="Cir_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBF1-interacting co-repressor CIR N-terminal" evidence="2">
        <location>
            <begin position="10"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4042006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="396" mass="46280" checksum="94C46354C215F4F6" modified="2024-10-02" version="1">MPLHLLGKKSWNVYNPANIARVRRDEAAAQAKEEAEEQRMQEVDAARRLAILRGETPPPLEDPEPEALPLRQAHDRDAYTTLSTGRKRKRRGEDDTDYEMRIARKRASAGDRAARELAVAKPNPTATSSPSLLDSKGHLTLFEPEPEQPQSRPRHEKNEEATREAARKERELKDQYQMRLVNAAGKDGQGLTDGGPWYASGDGEAAGAPVPSKNVFGREDPKRKAREAARLGASDPLAMMKRGAKMVRELERERRKEVEERGRELRALEEEERREERRRERKRREERHSRRREQGRDSADGDGGYGRRERSRGHRDDDSEKRHRGEERERGRDRRERSDAGERSRRDHHDRTRDRSRERDRRREDKHESDGRRNHDRHPRPHKPGHDRDTDRYRQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2025-10-08" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6STZ7</accession>
    <name>A0AAN6STZ7_9PEZI</name>
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        <recommendedName>
            <fullName evidence="2">Telomeric single stranded DNA binding POT1/Cdc13 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">C8A01DRAFT_43964</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854332">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="NA-bd_OB-fold"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
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            <end position="1511"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1064"/>
            <end position="1349"/>
        </location>
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        <location>
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        </location>
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            <end position="626"/>
        </location>
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        </location>
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        </location>
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        <location>
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        </location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
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        <location>
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        <location>
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        </location>
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        <location>
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        <location>
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            <end position="1224"/>
        </location>
    </feature>
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        <location>
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            <end position="1271"/>
        </location>
    </feature>
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        <location>
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            <end position="1300"/>
        </location>
    </feature>
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        <location>
            <begin position="1301"/>
            <end position="1311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4043039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1534" mass="165135" checksum="90E26A6DFE8525E3" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SUY4</accession>
    <name>A0AAN6SUY4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Eukaryotic integral membrane protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_43499</name>
    </gene>
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        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854326">
        <property type="protein sequence ID" value="KAK4043552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Transmembrane protein 115"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TMEM115/Pdh1/Rbl19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13377">
        <property type="entry name" value="PLACENTAL PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13377:SF3">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08551">
        <property type="entry name" value="DUF1751"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01160">
        <property type="entry name" value="DUF1751"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="148"/>
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    </feature>
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        <location>
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            <end position="197"/>
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    </feature>
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        <location>
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            <end position="381"/>
        </location>
    </feature>
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        <location>
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            <end position="322"/>
        </location>
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            <end position="333"/>
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    </feature>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4043552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="381" mass="41188" checksum="4974AFFDCDCD4C68" modified="2024-10-02" version="1">MPPRINIPPVTRIVLIVLGLQSVLSAAIRYRQWTANSEIVIPYLNLIPQLSLVYPWTFLTTTLVESNIFTLSIACVTLYNGGRYLERAWSSREFAKFLLVAAVVPNALCFGTSILFFALTRNERWTLMTIAGTIPLQISFLVAFSQLVPAHTVTLFRGLVSLRVPRFPLLYIGLVTLLCLTPMLTAASFLLAVYGFLVSWTYLRFYKVAFPDLDTSQPSSLRGDASETFAIAEFFPGPVRPVVATVSDQVFNVLVAMRLCVPFSAADISAARGDHHHTFSHRAGAPGSARAEAERRRALALRALDQRLHAATANAAARAQSAPVPPAVAPPIPSATGPTVQSQPQAPPPNAMTAQATGGSGMLGETNYNPDADADADRNGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SV15</accession>
    <name>A0AAN6SV15_9PEZI</name>
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        <recommendedName>
            <fullName evidence="2">Clr5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_43928</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854331">
        <property type="protein sequence ID" value="KAK4043146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SV15"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025676">
        <property type="entry name" value="Clr5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38788">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38788:SF3">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14420">
        <property type="entry name" value="Clr5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Clr5" evidence="2">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4043146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="220" mass="24424" checksum="DBD2985ADDE441D3" modified="2024-10-02" version="1">MTKQWDKYREIIIAEYKDQNKPLHEVQRFMMQRYGFRASTRAYRSRFDRWGVHKYSRRRRVRSMSLSRRESVSEGDMRPSPRQSPDMDEGSPQAATPVVATPNELFTPGICVATPATADFRSSLCLVKPDFPYTPITPSPSPAVAHGPGFPLNQFGCGLASFDSQNIGGYSSNSLAMYRQHPRGVVIVAPDVSGPGQSTMSMAGMPTAYGYSMGLLTGQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SV36</accession>
    <name>A0AAN6SV36_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_32231</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854325">
        <property type="protein sequence ID" value="KAK4043702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SV36"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042926193" evidence="2">
        <location>
            <begin position="21"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="137"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4043702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="266" mass="27451" checksum="8B6AFF89D941AB4E" modified="2024-10-02" version="1">MLFLTILTSIIAILPVCALAAPTDLNGTATIDDAPAPDRTTDEELAFSEALAALRNTVSRASAAHDAGSEEEDPDVLDDLERLLGIIADHVERMREAMQGTNGTNAPPATAASPAEAPAAHHAGTDNRNGDDSNNKAPAPAAGEAAQAPSAAASPAWAWAGPSNTTNDDATEKTPDDPAPVIINQADMFPDADTDADADDTTTQVGGGPQVQYNEPSGAINITCKGISVCNPVTIINEKGGKRIKLEKLDKAAAKGRKKAGKNWKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SV66</accession>
    <name>A0AAN6SV66_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_32112</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854324">
        <property type="protein sequence ID" value="KAK4043792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SV66"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24118">
        <property type="entry name" value="POTE ANKYRIN DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24118:SF99">
        <property type="entry name" value="POTE ANKYRIN DOMAIN FAMILY MEMBER 3C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="294"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="329"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4043792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="689" mass="76017" checksum="ADD9B49C88BB4777" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SVD6</accession>
    <name>A0AAN6SVD6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nitrate/nitrite transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_12844</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Nitrate/nitrite porter (TC 2.A.1.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854325">
        <property type="protein sequence ID" value="KAK4043670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SVD6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015112">
        <property type="term" value="F:nitrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015113">
        <property type="term" value="F:nitrite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044772">
        <property type="entry name" value="NO3_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004737">
        <property type="entry name" value="NO3_transporter_NarK/NarU-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00886">
        <property type="entry name" value="2A0108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23515">
        <property type="entry name" value="HIGH-AFFINITY NITRATE TRANSPORTER 2.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="297"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="400"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="432"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="465"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="36"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4043670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="494" mass="53071" checksum="3FFBF5196E852E14" modified="2024-10-02" version="1">MGFKFSHLYARPDVNTATLKARSIPFFNPVDIYGRVFFFSWFGFMIAFWAWYTFPPLLTHTIKYDLHLTPVEVANSNIVSLCATLLVRLVAGPLCDQFGPRKVFGGLLLVGSIPLGLAPLVHNATGLYVSRFFIGILGGSFVPCQVWSTGFFDKNVVGTANALTGGFGNAGGGITYFIMPAVYDGLIGARYTPGQAWRLTFLVPLAMVITTGIALLLLCPDTPTGKWSDRHLRAVESAHQEPEKSPAIAITIPINLDLEAYTHTTTTTTPQKPSSAEIITPPTPREILRVTLSPQTIFHILTYMCSFGTELAVNAILASYYAKNFPLLGQTAAANWAAMFGFLNFVTRPLGGIVSDLLYKYFGSSEAALWYKKGWVVVCGLVTGALLVVIGEVDPKAQGVMFGLVGVMAVFLEAGNGANFSLLPHVHPRANGVLSGLTGAGGNLGGVVFAVVFRFMGGGTDYAKGFWVIGVVNLVVYVAVSWIPPLPKGQVGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SVE4</accession>
    <name>A0AAN6SVE4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_43498</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854326">
        <property type="protein sequence ID" value="KAK4043551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SVE4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24362:SF309">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24362">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE NEK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4043551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="256" mass="28995" checksum="0085FE3966A21E50" modified="2024-10-02" version="1">MDLPEDEPWPPVPPDVTIAAIEVETPELSVTANSMLYRLKGHPAKVYKLRGEFREYQLQKAAGDCAIPVRGKVLGKSRNGNGEIVFYGFMMDLATPIPTTLPPSQRHDLMHQMIRTVQRLHTKQIVHGDIKLENMLLDNQGRLRLCDFCEGRYVDEDMHTWDGNSTLHFESPNRLLRGEQFGRDPPPPTTEDDLYSLGLSIWQLYTGKVPHEDVAGDDMDLKERQRNGETINVAAVRDPEACRIITNLLRKGGARI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SVY4</accession>
    <name>A0AAN6SVY4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phospho-2-dehydro-3-deoxyheptonate aldolase</fullName>
            <ecNumber evidence="6">2.5.1.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_31361</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>D-erythrose 4-phosphate + phosphoenolpyruvate + H2O = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14717"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="2.5.1.54"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the class-I DAHP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.54" evidence="6"/>
    <dbReference type="EMBL" id="MU854318">
        <property type="protein sequence ID" value="KAK4044572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SVY4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000005">
        <property type="entry name" value="Phospho-2-dehydro-3-deoxyheptonate aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006218">
        <property type="entry name" value="DAHP1/KDSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006219">
        <property type="entry name" value="DAHP_synth_1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00034">
        <property type="entry name" value="aroFGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009395">
        <property type="entry name" value="PRK12755.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21225">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE DAHP SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21225:SF18">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE, PHENYLALANINE-INHIBITED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00793">
        <property type="entry name" value="DAHP_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001361">
        <property type="entry name" value="DAHP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4 6" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAHP synthetase I/KDSA" evidence="7">
        <location>
            <begin position="57"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR001361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4044572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="375" mass="40903" checksum="5B1F5008AFC1D3ED" modified="2024-10-02" version="1">MSSFYIENKNVGNKAESEDWRIRGYNPLTPPGLLQHEIAQTPESKQTVLQGREEAAAIVNGTDEKQRLLVVIGPCSIHDPQAALEYCDMLLKEKEKHKDELLIVMRSYLEKPRTTVGWKGLINDPDLDNSFQINKGLRLSRQLFVDLTSRGMPIASEMLDTISPQFLADLLSVGAVGARTTESQLHRELASGLSFPVGFKNGTDGSLTVAVDAIGAVRHPHHFLSVTKPGVVAIVGTVGNEDCFVILRGGTRGTNYDAQSIAEAKAALQKSGVWQRLMVDCSHGNSLKNHKNQPKVAATLAEQIEKGEEAIMGVMIESHINEGSQKVPKEGKEGLKYGVSITDACIGWEDTVQTLDVLANAVKRRREVLGQNSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SW14</accession>
    <name>A0AAN6SW14_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">6-phosphogluconate dehydrogenase C-terminal domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_31771</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>sn-glycerol 3-phosphate + NAD(+) = dihydroxyacetone phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.8"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854321">
        <property type="protein sequence ID" value="KAK4044168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SW14"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141152">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046168">
        <property type="term" value="P:glycerol-3-phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011128">
        <property type="entry name" value="G3P_DH_NAD-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051729">
        <property type="entry name" value="Opine/Lysopine_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003421">
        <property type="entry name" value="Opine_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38015">
        <property type="entry name" value="BLR6086 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38015:SF1">
        <property type="entry name" value="OPINE DEHYDROGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01210">
        <property type="entry name" value="NAD_Gly3P_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02317">
        <property type="entry name" value="Octopine_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal" evidence="3">
        <location>
            <begin position="7"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Opine dehydrogenase" evidence="4">
        <location>
            <begin position="177"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00048683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4044168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="368" mass="39939" checksum="9DB159A4946108C8" modified="2024-10-02" version="1">MHMQPTVSIVGAGPAGFALAAELESQGRSVLLYSHPTHLRHANHVKRNGHLATSGLMEGATNLRVTTDMGEAVAFSRVMILTVPSTGQETVLQELRNFSLQQHAIIAVPGNLFSLIADLEVGCVFETNLSPYSCRMDEGGLMVLGKKELVSIAALHQDLDPAVYETVASIFPTQLKWCSSVIEVCLSNVNGVFHPLMMLMNAGRIENTSGDFFIYSAGLTTSVANAMLAIDRVRIKIGEALGLRLKSAVEISNECYGQGFTDFVDLAQNSPPHNKLKAPTNLDNRNITEDVPDLLVSWHCLAEKLGVDATPIKAVITLAEMATGVNYFETGRNLRRLHLEHVSRAELIERFGCVQDKVVTSSGVGCRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SWP1</accession>
    <name>A0AAN6SWP1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_31044</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854316">
        <property type="protein sequence ID" value="KAK4044856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SWP1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF12">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_1G14540)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4044856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="283" mass="29036" checksum="A17C232AC85AD42F" modified="2024-10-02" version="1">MAEAQLHDFPSLFSLEGKVAVVTGGSRGLGLSAASALLQAGAQKVFISSRKPAACASACAALNALPNLRPGARAIPVPADAATLDGVKHLLAQVSAQTDHVDVLLANAGASWGEAFDTHPDGAFAKVMDLNVRGVFNVIREFAPLLQKRASAKDPSRVVITASVAGLGIGTLGKQGTYGYSASKAAVIHLGRNLAVELGPRGITVNSVCPGFFPSKMSNGLLEMSGGAEALGKENPMRRLGRPEDIAGVVVYLTSRAGAHVNGAAIEVDGGALWQRGQLDVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P422</accession>
    <name>A0AAN6P422_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_21447</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854883">
        <property type="protein sequence ID" value="KAK4031314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P422"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4031314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="112" mass="11773" checksum="41555307722FC13F" modified="2024-10-02" version="1" fragment="single">SASTARFFYIPPVGAGLELASRGFRVREGDPSAAISGVSLYPPLLQDGYDPQSGDVGKSQADAILIPSEDEFDLDSRSDISFESLDGLLPDTRNKVKSGCVTGTGMCGRPTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P471</accession>
    <name>A0AAN6P471_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_42112</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the plant acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854812">
        <property type="protein sequence ID" value="KAK4031428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P471"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051283">
        <property type="entry name" value="Sec_Metabolite_Acyltrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31896">
        <property type="entry name" value="FAMILY REGULATORY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G14730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31896:SF69">
        <property type="entry name" value="FAMILY REGULATORY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G14730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02458">
        <property type="entry name" value="Transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4031428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="487" mass="55057" checksum="05EDAFC4DDD047F7" modified="2024-10-02" version="1">MFSFFFGPSKAPQCVPTDHVVPVGFFDDTIIFRTFVLYTVFVFDDVLDAQKLHSSLERVVARPGWNKLGARLRRNDHGELEHHIPAAFSQDRPAIGFDHQDLSDLAVEDHPTASHIPRPPRNGRPAIVVDPDDLSELVYGPDVPRRLDDYLYADRPQLGLRVVSFKNSTIIVLHWIHLAFDATAKRSLLDAWTLMLQGKEDEIPEPLAPDNYVLENIGKKPTKPHALAHRRVSMPGLVSWALRNAYPLFIRPKEHRMVCVPAAYLAKLREKALAELNAQAAAAGQKEEPFLSEGDVLLAWVTRLAMANISKDSERIIAVQQAYQWRRVLKDLIPANTPFLGNCVGFLVTLMPAKDLLRKPLSFLASHIRRSIEEQGSREQIEAYASFIRLDPKNRAPPFFGESSMQLLMFSNWQKANMYGTDLSAAAVKPRDTTLMPSYVQSMQGPYNFTDGIIIVGKDAEGNYWLSAYRVKGLWEMMETEMARDKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P4Z4</accession>
    <name>A0AAN6P4Z4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_21129</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854722">
        <property type="protein sequence ID" value="KAK4031705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P4Z4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071218">
        <property type="term" value="P:cellular response to misfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000069">
        <property type="entry name" value="ER associated DnaJ chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051100">
        <property type="entry name" value="DnaJ_subfamily_B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015399">
        <property type="entry name" value="DUF1977_DnaJ-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43908">
        <property type="entry name" value="AT29763P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43908:SF3">
        <property type="entry name" value="AT29763P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09320">
        <property type="entry name" value="DUF1977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="51"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="18"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="141"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4031705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="356" mass="39139" checksum="EA22E0C6776840F1" modified="2024-10-02" version="1">MPDASTSGASASQNDASARNRREHNQGNQERKYTVEQKAAVLRIRRCQPTAFYEILELQKTCTDGEVKKAYRKLSLLTHPDKNGHEHADEAFKMVARAFSVLGDKEKRDKFDRFGTDPDSRFASAQAQAQQNPFAGFAGRRAGGGGGGGGWGEEEISPEEMFARFFGGGGFGGPFGDFGGGPQFVFNFGGGPGVRVHQFGGARPRARPRNPGQEEPASAWSTIIGLLPIILLVVWPILSSIFSGLASSTPATPSMAFDEPHPPLYTMERTMPHFKVKYYLNPADVHAYNPSKLSSLDKRAEVVLVQQLRLKCENEMAHKQQLQNAAQGWFFQDPDKMEVAKTFDMPACRRLNSLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P609</accession>
    <name>A0AAN6P609_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyanovirin-N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_20648</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854630">
        <property type="protein sequence ID" value="KAK4032260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P609"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043002402" description="Cyanovirin-N domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4032260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="179" mass="19180" checksum="307C4D28DF04BB9D" modified="2024-10-02" version="1">MGPAASLVALLCGVSLAYQGTVGIERALGGHLVQNAVDNCTESSQSPSYWRIENFVLKVYNWENGGSTGTFGFTSYYSATNTTVECMVQDVDLAKLADGPWSKCKSAGTEFRFDLTDISLTMKETWTCSGSPGRIFNANATGRIMLHGCLDNDTVKGVESDCDLMELEMSANATSSAII</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P671</accession>
    <name>A0AAN6P671_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_51635</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU855031">
        <property type="protein sequence ID" value="KAK4031178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P671"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056125">
        <property type="entry name" value="DUF7708"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF14">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24809">
        <property type="entry name" value="DUF7708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="DUF7708" evidence="2">
        <location>
            <begin position="67"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="3">
        <location>
            <begin position="217"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4031178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="567" mass="64983" checksum="1AAD132AE42B5C18" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P6J3</accession>
    <name>A0AAN6P6J3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Glycoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_51545</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854856">
        <property type="protein sequence ID" value="KAK4031343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P6J3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032311">
        <property type="entry name" value="DUF4982"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048229">
        <property type="entry name" value="GalB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051913">
        <property type="entry name" value="GH2_Domain-Containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040605">
        <property type="entry name" value="Glyco_hydro2_dom5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006101">
        <property type="entry name" value="Glyco_hydro_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006104">
        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Ig-like_GH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008964">
        <property type="entry name" value="Invasin/intimin_cell_adhesion"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041463">
        <property type="entry name" value="GalB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42732">
        <property type="entry name" value="BETA-GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42732:SF1">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16355">
        <property type="entry name" value="DUF4982"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18565">
        <property type="entry name" value="Glyco_hydro2_C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02837">
        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00132">
        <property type="entry name" value="GLHYDRLASE2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="beta-Galactosidase/glucuronidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49373">
        <property type="entry name" value="Invasin/intimin cell-adhesion fragments"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042878249" evidence="4">
        <location>
            <begin position="25"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolases family 2 sugar binding" evidence="7">
        <location>
            <begin position="135"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich" evidence="5">
        <location>
            <begin position="240"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2 catalytic" evidence="6">
        <location>
            <begin position="359"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4982" evidence="8">
        <location>
            <begin position="695"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2" evidence="9">
        <location>
            <begin position="767"/>
            <end position="870"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF18565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4031343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="874" mass="94280" checksum="6B280F8678E218C6" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P7B0</accession>
    <name>A0AAN6P7B0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Alternative oxidase</fullName>
            <ecNumber evidence="17">1.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">C8A01DRAFT_20741</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes cyanide-resistant oxygen consumption. May increase respiration when the cytochrome respiratory pathway is restricted, or in response to low temperatures.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16 17">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="16 17">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the alternative oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="17"/>
    <dbReference type="EMBL" id="MU854642">
        <property type="protein sequence ID" value="KAK4032152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P7B0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098803">
        <property type="term" value="C:respiratory chain complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009916">
        <property type="term" value="F:alternative oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010230">
        <property type="term" value="P:alternative respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1260.140:FF:000002">
        <property type="entry name" value="Alternative oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.140">
        <property type="entry name" value="Alternative oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002680">
        <property type="entry name" value="AOX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038659">
        <property type="entry name" value="AOX_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31803">
        <property type="entry name" value="ALTERNATIVE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31803:SF3">
        <property type="entry name" value="ALTERNATIVE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01786">
        <property type="entry name" value="AOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005229">
        <property type="entry name" value="AOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 17" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12 16 17" id="KW-0408">Iron</keyword>
    <keyword evidence="14 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 16 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 17" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="binding site" evidence="16">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00025285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR005229-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAK4032152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="343" mass="39313" checksum="C4F50B12A87A0B0C" modified="2024-10-02" version="1">MAQRVRLPYKLLRLQEHASGPRSKPLSRPSLARGRQLRIQYYQVRLSSTAIPQSKNDTVLAKQTSGVSSAPLTWPHKGWDDKVVLEVVPSHRKPRTVSDRIAWGMDFLTGMPPELKPDGKHRKATAYTPMTESQWLVRFVFLETVAGIPGAVAGGLRHLHSIRRFKLDQGWIKTLLEESYNERMHLLSFLAMYPPGRLMRCMVFATQGIFYNTMFIGYLMSPSFCHRLVGYLEDEAVATYTKCLEEMDKGRLPKWTDPSFKIPDIAIKYWNMPEGRRTMRDLILYIRADEASHRGVNHTLGNLDQTSDPNPFIEQHSNVSHMHLAAVKPAGLEREEVLEKYAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P7Y0</accession>
    <name>A0AAN6P7Y0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">GPI ethanolamine phosphate transferase 1</fullName>
            <ecNumber evidence="14">2.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">C8A01DRAFT_19644</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 14">Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the PIGG/PIGN/PIGO family. PIGN subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.-.-.-" evidence="14"/>
    <dbReference type="EMBL" id="MU854532">
        <property type="protein sequence ID" value="KAK4033408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P7Y0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051377">
        <property type="term" value="F:mannose-ethanolamine phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16020">
        <property type="entry name" value="GPI_EPT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000015">
        <property type="entry name" value="GPI ethanolamine phosphate transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007070">
        <property type="entry name" value="GPI_EtnP_transferase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017852">
        <property type="entry name" value="GPI_EtnP_transferase_1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037671">
        <property type="entry name" value="PIGN_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12250:SF0">
        <property type="entry name" value="GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12250">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN, CLASS N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04987">
        <property type="entry name" value="PigN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 14" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="460"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="496"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="560"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="587"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="614"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="639"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="680"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="718"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="768"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="837"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="876"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="911"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="942"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="domain" description="GPI ethanolamine phosphate transferase 1 C-terminal" evidence="16">
        <location>
            <begin position="450"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="793"/>
            <end position="824"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAK4033408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1006" mass="110958" checksum="5CEDB1C7A85B0A8E" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P889</accession>
    <name>A0AAN6P889_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_21237</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854760">
        <property type="protein sequence ID" value="KAK4031566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P889"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF12">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="83"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="455"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4031566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="609" mass="67934" checksum="F39CFCF0CDB5FA95" modified="2024-10-02" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P8W9</accession>
    <name>A0AAN6P8W9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_20416</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854600">
        <property type="protein sequence ID" value="KAK4032513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P8W9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4032513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="147" mass="16514" checksum="90F1EAD3CADC4CCC" modified="2024-10-02" version="1">MALLAASRTAPTVSLSRRSDVISTLYPLVNSAVQFQQLIGSAAFHLLVRTYFAATILATVSLWASRSIAWRTFLASRILVARALFLAKRLAWTAWDGKRSRRFRKRLEFELFILLLGPGGNTVMLMLFWPGWLMLAALGWGVWQLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P9F2</accession>
    <name>A0AAN6P9F2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_39393</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854493">
        <property type="protein sequence ID" value="KAK4034135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P9F2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="74"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="236"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="324"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="374"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="132"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="236"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="328"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="380"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4034135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="394" mass="44180" checksum="12A808AD917F0586" modified="2024-10-02" version="1">MNLGPSEPGRPDPKGKRKRNQRSATPSPRPSKRHANRVQNDDEEAYHQPLQMPELFLGAVQEAHHDEFALVAPAEHESSPVVEDESALTRLGNRSGHRSTKARVTACEEELAKHLNLIHTQDSKLSTQEDLMANHTTSIEGLESRVKSIEEKPSADKGVKTMEESVVELMDRLSSKQEQNHINTRLDAFSKDLAAEKVRGDNCDEAVAKQAKLMKRRLKAQKLHAGQIEELSNRVTELEEKFSGDKDSSDSEDEDDAKATAPLAQEQLVDLTARITQLEKKVKSQNKKRQSSTDKILIRLNALESEYPKLKKATEDRHAALERRVGEQGSQLARQEQLAGSRSNIVPGIRAQIQTLPPRPAQAANNHSYRQGLHHPLQLHPHHPHHPHHPHGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P9K3</accession>
    <name>A0AAN6P9K3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_41262</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854625">
        <property type="protein sequence ID" value="KAK4032301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P9K3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4032301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="412" mass="44505" checksum="0B208363699BDD6F" modified="2024-10-02" version="1">MSAQRVPDHEKEGQGGGQADHGAHSMTVVNDGVASVITPAMVSGILMVVPAFLDTGHWNKAQCTWEGHDIFGPVNRDPSRGWGDFVFQYGAGRLDRVIIHYSLVQELRTSRDPETTMSRFRTYLKLLGNNTHSPFSDAQTTTHFRLNLGGTYNLPPLDVRFGFTYGPDGHDGFIYSCIGGTRYAIDVHPAATRANLHVTPGAALAKHDPTLNPDGYHLNGSDGIGAQQGESTMVGDRTHFAAMLRGLSKAVDALEAKEDCAGHLSDHMICGVTIPARPEDIVDISAVDNILGAFFSVREATRIDIEITRWNITKHWIDEYQKRIEEEAVPLPRAASAENMTPAPPSVNVHKTTTPQRPTNTAILAATVAATSTTKRKTRCAAEKAESPAAKRRAGIAPGAATKIAQQAGNRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PAI1</accession>
    <name>A0AAN6PAI1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Coatomer subunit zeta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">C8A01DRAFT_18444</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 12">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 12">Golgi apparatus membrane</location>
            <topology evidence="1 12">Peripheral membrane protein</topology>
            <orientation evidence="1 12">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Cytoplasmic vesicle</location>
            <location evidence="12">COPI-coated vesicle membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854465">
        <property type="protein sequence ID" value="KAK4034794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PAI1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14829">
        <property type="entry name" value="Zeta-COP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000013">
        <property type="entry name" value="Coatomer subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039652">
        <property type="entry name" value="Coatomer_zeta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11043:SF0">
        <property type="entry name" value="COATOMER SUBUNIT ZETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11043">
        <property type="entry name" value="ZETA-COAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 12" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 12" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="14">
        <location>
            <begin position="53"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU366053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK4034794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="204" mass="22445" checksum="8A95B8D9C03A8E60" modified="2024-10-02" version="1">MSPGMSLYSVNAILILSSEDGSRIFTKYYTPPHQAAANPGGAGTTPASSQNPYPDKTAQTRFEKGLLQKTAKQTGDILLFDNHIVLYKMESDVALYVVGSLDDNEILLYNVLLALRDSLHLLFKQSVDKRTIIENYDLVSLAVDEICDDGVVLETDPTIIVQRCSKAPSQDVNLSRIDPFSEQGVNNLAQLGKAKLTDWLRQGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PAN4</accession>
    <name>A0AAN6PAN4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sterol regulatory element-binding protein cleavage-activating protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">C8A01DRAFT_38650</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20">Escort protein required for cholesterol as well as lipid homeostasis. Regulates export of the SCAP-SREBP complex from the endoplasmic reticulum to the Golgi upon low cholesterol, thereby regulating the processing of sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2. At high sterol concentrations, formation of a ternary complex with INSIG (INSIG1 or INSIG2) leads to mask the ER export signal in SCAP, promoting retention of the complex in the endoplasmic reticulum. Low sterol concentrations trigger release of INSIG, a conformational change in the SSD domain of SCAP, unmasking of the ER export signal, promoting recruitment into COPII-coated vesicles and transport of the SCAP-SREBP to the Golgi: in the Golgi, SREBPs are then processed, releasing the transcription factor fragment of SREBPs from the membrane, its import into the nucleus and up-regulation of LDLR, INSIG1 and the mevalonate pathway. Binds cholesterol via its SSD domain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPII-coated vesicle membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat SCAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854462">
        <property type="protein sequence ID" value="KAK4034884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PAN4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032936">
        <property type="term" value="C:SREBP-SCAP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008203">
        <property type="term" value="P:cholesterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045540">
        <property type="term" value="P:regulation of cholesterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032933">
        <property type="term" value="P:SREBP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053958">
        <property type="entry name" value="HMGCR/SNAP/NPC1-like_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030225">
        <property type="entry name" value="SCAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46378">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN CLEAVAGE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46378:SF1">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN CLEAVAGE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12349">
        <property type="entry name" value="Sterol-sensing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0153">Cholesterol metabolism</keyword>
    <keyword evidence="19" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="15 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="18" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="16" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="8 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 23" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7 21" id="KW-0853">WD repeat</keyword>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="322"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="423"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="499"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="24">
        <location>
            <begin position="293"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="21">
        <location>
            <begin position="665"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="978"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1140"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="22">
        <location>
            <begin position="995"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="22">
        <location>
            <begin position="1019"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="22">
        <location>
            <begin position="1147"/>
            <end position="1159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00045958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="KAK4034884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1167" mass="128801" checksum="1E9CFBD54A80BC06" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PBC7</accession>
    <name>A0AAN6PBC7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_48545</name>
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    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854451">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PBC7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="2-5A-DEPENDENT RIBONUCLEASE"/>
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    </dbReference>
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        <property type="match status" value="5"/>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
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        <property type="match status" value="15"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="15"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
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        <location>
            <begin position="356"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
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            <end position="421"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="422"/>
            <end position="454"/>
        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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            <end position="533"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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            <end position="665"/>
        </location>
    </feature>
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        <location>
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            <end position="698"/>
        </location>
    </feature>
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        <location>
            <begin position="699"/>
            <end position="731"/>
        </location>
    </feature>
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        <location>
            <begin position="732"/>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
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            <begin position="204"/>
            <end position="361"/>
        </location>
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        <location>
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        </location>
    </feature>
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            <end position="321"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK4035215.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="898" mass="95433" checksum="4CA587466AD701FF" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PBN2</accession>
    <name>A0AAN6PBN2_9PEZI</name>
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    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF29">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
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            <end position="220"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
    <sequence length="564" mass="63857" checksum="7DBF84445E7631A2" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PC28</accession>
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        <submittedName>
            <fullName evidence="3">Carbohydrate esterase</fullName>
        </submittedName>
    </protein>
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        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854542">
        <property type="protein sequence ID" value="KAK4033257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PC28"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01833">
        <property type="entry name" value="XynB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051532">
        <property type="entry name" value="Ester_Hydrolysis_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30383:SF2">
        <property type="entry name" value="CELLULOSE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30383">
        <property type="entry name" value="THIOESTERASE 1/PROTEASE 1/LYSOPHOSPHOLIPASE L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042939283" evidence="1">
        <location>
            <begin position="19"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="2">
        <location>
            <begin position="36"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4033257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="235" mass="25407" checksum="E853CB2B67D6C3C8" modified="2024-10-02" version="1">MHVSSILSVFGLASLALASPVEVAERQAQKLRIMPLGDSITEITCWRALVWDQLAAAGLADKVQYVGSQNSNPQNCKPATANWDQHHEGHSGWQAVNIANQYLTGWLKSTPADIVMFMLGTNDVNGGRSTDDIIAAFTKMVTIMRAANPKTKIIVDIVIPLPFANSGIQAINARIPEWARGLNTTESPIVIADCYTGFTSSMLRDGVHPNAEGDKVIASRVGPLLLDFVRQSLAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PCI2</accession>
    <name>A0AAN6PCI2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_19561</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854526">
        <property type="protein sequence ID" value="KAK4033497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PCI2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22679">
        <property type="entry name" value="FHA_SLMAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.20:FF:000127">
        <property type="entry name" value="Uncharacterized protein C3H7.13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051176">
        <property type="entry name" value="Cent_Immune-Sig_Mod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15715">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 170 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15715:SF46">
        <property type="entry name" value="TO VACUOLE TARGETING VPS64, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02420)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="704"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="domain" description="FHA" evidence="4">
        <location>
            <begin position="155"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="369"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="500"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="611"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="452"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="559"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="11"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="369"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="403"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="611"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4033497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="734" mass="79607" checksum="8C65E9A83EB584B9" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PCS7</accession>
    <name>A0AAN6PCS7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Glycoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">C8A01DRAFT_18193</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854455">
        <property type="protein sequence ID" value="KAK4035105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PCS7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="7 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043035354" evidence="11">
        <location>
            <begin position="20"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="12">
        <location>
            <begin position="30"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK4035105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="378" mass="40541" checksum="4FFAC67BDC93953A" modified="2024-10-02" version="1">MKPILLASLLWAATSGAAAAPLRQTRPELPRLILYYQTTHDAAGRPISLLPLINKQHIALTHLIVGAFHVHANGTLHLNDHPPSHPRYDTLWTETRILQSAGVKILGMVGGAARGSFTPHTLDGGNGNTTFTTAAAFERAYALLRDAIDAHDLDGVDLDVEEPMSQRGIARLVRRLRADFGPRFVVSLAPVATALLGGGGRDGGRGGGNLSGFSYAALEKQVGRGQVGFYNAQFYNGFGGVRDTALFDKIVAAGWEAGRVVIGQLTSPANGAGFVGHAQLGRTVAALRRRYGEIGGVVGWEYFNGVPGGLGEPWKWAQSMTRILRPGREPVLRISRETAEELNRAWMESTAAGRGGRLGTERWVGLVPNVDYLGMVNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PD45</accession>
    <name>A0AAN6PD45_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Apc15p protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_38244</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854449">
        <property type="protein sequence ID" value="KAK4035285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PD45"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008402">
        <property type="entry name" value="APC_su15/mnd2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05841">
        <property type="entry name" value="Apc15p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="366"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4035285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="400" mass="43661" checksum="EF4B75E6A484B5A5" modified="2024-10-02" version="1">MFAMLPELTPRDSHSLWYTSPRNPSSSLYPLDPSHSTADNGGPQATTTAPATTTTGTTPNPTQNTPAPTQTATARQANAHSASATAQIIDRSALGRLQAEELLIERRRTAVTNLGSTWLKPVGVAKTLFQMREERREAEEHAEAMRREMLAQELADAAAQGAAEEEAQGLEGGGEDEEMMEEEDGGVDLDADIPDEDAGMGFGYDGASDEEEDEDEDEEEEGEEDNEDEEELSEDELERRQEIARIRATEARMREVSEQNDANLRRSDSIFDFDEEPSDEDRSQLLEEEGLVRGHPHPQADVQVPGPVGAGHDMDMDADLDDDIPEADGGGYEHTDSEASLDSGDEGHDISYARSSRMVHGRSSLRRSQALRSSLDISGLLSRDGSSMAGSSPHMRRGNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PDC2</accession>
    <name>A0AAN6PDC2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">pyruvate, water dikinase</fullName>
            <ecNumber evidence="5">2.7.9.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Pyruvate, water dikinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">C8A01DRAFT_17987</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>pyruvate + ATP + H2O = phosphoenolpyruvate + AMP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:11364"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.9.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PEP-utilizing enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.9.2" evidence="5"/>
    <dbReference type="EMBL" id="MU854448">
        <property type="protein sequence ID" value="KAK4035317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PDC2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008986">
        <property type="term" value="F:pyruvate, water dikinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000010">
        <property type="entry name" value="Phosphoenolpyruvate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000017">
        <property type="entry name" value="Phosphoenolpyruvate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.10">
        <property type="entry name" value="Phosphohistidine domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008279">
        <property type="entry name" value="PEP-util_enz_mobile_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006319">
        <property type="entry name" value="PEP_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018274">
        <property type="entry name" value="PEP_util_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000121">
        <property type="entry name" value="PEP_util_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023151">
        <property type="entry name" value="PEP_util_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036637">
        <property type="entry name" value="Phosphohistidine_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002192">
        <property type="entry name" value="PPDK_AMP/ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01418">
        <property type="entry name" value="PEP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005057">
        <property type="entry name" value="PRK06464.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43030">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43030:SF1">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00391">
        <property type="entry name" value="PEP-utilizers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02896">
        <property type="entry name" value="PEP-utilizers_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01326">
        <property type="entry name" value="PPDK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000854">
        <property type="entry name" value="PEP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52009">
        <property type="entry name" value="Phosphohistidine domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00742">
        <property type="entry name" value="PEP_ENZYMES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00370">
        <property type="entry name" value="PEP_ENZYMES_PHOS_SITE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate phosphate dikinase AMP/ATP-binding" evidence="15">
        <location>
            <begin position="31"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilising enzyme mobile" evidence="14">
        <location>
            <begin position="398"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilising enzyme C-terminal" evidence="16">
        <location>
            <begin position="490"/>
            <end position="799"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAK4035317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="809" mass="87747" checksum="F682B6D98C64B8BA" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PDY7</accession>
    <name>A0AAN6PDY7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thymidylate kinase</fullName>
            <ecNumber evidence="3">2.7.4.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">C8A01DRAFT_17112</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; dTTP biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the thymidylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.9" evidence="3"/>
    <dbReference type="EMBL" id="MU854417">
        <property type="protein sequence ID" value="KAK4038847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PDY7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004798">
        <property type="term" value="F:dTMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006233">
        <property type="term" value="P:dTDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006227">
        <property type="term" value="P:dUDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01672">
        <property type="entry name" value="TMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000679">
        <property type="entry name" value="Thymidylate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00165">
        <property type="entry name" value="Thymidylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039430">
        <property type="entry name" value="Thymidylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018095">
        <property type="entry name" value="Thymidylate_kin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018094">
        <property type="entry name" value="Thymidylate_kinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00041">
        <property type="entry name" value="DTMP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10344">
        <property type="entry name" value="THYMIDYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10344:SF1">
        <property type="entry name" value="THYMIDYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02223">
        <property type="entry name" value="Thymidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01331">
        <property type="entry name" value="THYMIDYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylate kinase-like" evidence="11">
        <location>
            <begin position="55"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="18"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK4038847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="300" mass="32640" checksum="674888BF4581C255" modified="2024-10-02" version="1">MASINDLATAASALVNPAAAPHSSLPDPAQTQTDDDRSAQGHGESAVARGALVVLEGLDRSGKTTQVKLLEQRFVELGRKVKVMRFPDRTTPIGQMIDSYLKSQVDMDDHVIHLLFSANRWEAAKTMTSLLTAGVTVLCDRYYHSGVVYSAAKQNPSLTLSWARAPEVGLPRPDLVLFLDLDENQARARGGWGGEAYEKAEMQRRVRELFWGLSLGKIGTASVVPEAGAVGPKEEVAVGPPTTQPLTGTEYRFRQEEEDLHVIDAGASVEEVAEEVWKVVKARVEAVENGEVGRLVRRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PE27</accession>
    <name>A0AAN6PE27_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_18249</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854457">
        <property type="protein sequence ID" value="KAK4035033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PE27"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053037">
        <property type="entry name" value="Pericyclase_pydY-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38115">
        <property type="entry name" value="LIPOCALIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38115:SF1">
        <property type="entry name" value="LIPOCALIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4035033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="186" mass="20328" checksum="06A2F4536050F8B3" modified="2024-10-02" version="1">MAAPPSANILNLSGTWILNRQLSDDFDSTFQLQGISWPIRKILSWAGVALHLTQTSAPSSSSPGKPPVTTITAKQTITPGGFNSEEAYVLDNSVKHASLPIFGAVSVRTRYTPLDEIEDAELRERLAKDGATVAIQEFAESKGGDWKTEGVWGFEVVGGERRFTRTNITTGRGERVVARLAYDYRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PE62</accession>
    <name>A0AAN6PE62_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_16736</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854405">
        <property type="protein sequence ID" value="KAK4039273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PE62"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF157">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="546"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="577"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="601"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="632"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="664"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="741"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="780"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="821"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="851"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="881"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="917"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="506"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4039273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="979" mass="104305" checksum="416380FED54D5C4D" modified="2024-10-02" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PF27</accession>
    <name>A0AAN6PF27_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_36181</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854391">
        <property type="protein sequence ID" value="KAK4039804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of cell cycle process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="Spg1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Septum-promoting GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017231">
        <property type="entry name" value="Small_GTPase_Tem1/Spg1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="56"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4039804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="340" mass="37031" checksum="45EE04580F1164BB" modified="2024-10-02" version="1">MEQEQALAPAAVVASDPAPAPASIPAPVPVPIPTDPTDPHDDTLGALESAPPQAVPDHHIHDQNGYHEQHQVQLQPADHSVNNSPRAHYPADTTDSEPTARYATPPIPAPTISRPPSGLSGQGAAYGADQVSRAGSNGAATESQNPGRNHVVIKVGMVGDAQIGKTSLMVKYVEGSWDEDYIQTLGVNFMEKTISIRNTEITFSIWDLGGQREFVNMLPLVCNDAVAILFMFDLTRKSTLNSIKEWYRQGRGFNKTAIPVLVGTKYDHFVNLSREEQEEISNQARRFAKAMRAALIFSSTSHSINVQKIFKIVLSKAFDLKCTIPEITNVGEPLLIYQSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PFS5</accession>
    <name>A0AAN6PFS5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_36718</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854404">
        <property type="protein sequence ID" value="KAK4039298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PFS5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="398"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="431"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="495"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="523"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="109"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="655"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4039298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="685" mass="76565" checksum="EA460D31B3160BED" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PFV4</accession>
    <name>A0AAN6PFV4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_46748</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854390">
        <property type="protein sequence ID" value="KAK4039852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PFV4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="912"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1049"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1054"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1087"/>
            <end position="1109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4039852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1125" mass="127663" checksum="54FDCD17F7D7B713" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PFW7</accession>
    <name>A0AAN6PFW7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Inorganic pyrophosphatase</fullName>
            <ecNumber evidence="4">3.6.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Pyrophosphate phospho-hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">C8A01DRAFT_16719</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>diphosphate + H2O = 2 phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24576"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="EC" id="3.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.1" evidence="4"/>
    <dbReference type="EMBL" id="MU854405">
        <property type="protein sequence ID" value="KAK4039255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PFW7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006796">
        <property type="term" value="P:phosphate-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00412">
        <property type="entry name" value="pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.80.10:FF:000004">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.80.10">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008162">
        <property type="entry name" value="Pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036649">
        <property type="entry name" value="Pyrophosphatase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10286">
        <property type="entry name" value="INORGANIC PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00719">
        <property type="entry name" value="Pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50324">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00387">
        <property type="entry name" value="PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
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            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
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            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
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            <end position="27"/>
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    </feature>
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            <end position="61"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
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            <end position="75"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00006220"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012146"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00032535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK4039255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="389" mass="42792" checksum="64477C9CF2457A06" modified="2024-10-02" version="1">MPPPQSPRPGQSQRRGLASHSGPTPAAGTPPPPWSQQSLLFSADSSSAAAAAAKISPPTAATNPSTAQLRPGSSSISRTAQLARHLQARSYTTANTTTKMASQYTVRKVGAPYTLDHRVYIEKDGVPVSPFHDIPLYANQEQTILNMVVEIPRWTNAKLEISKDELLNPIKQDIKKGKLRYVRNCFPHKGYLWNYGAFPQTWEDPNAIHPETKAKGDNDPLDVCEIGELVGYTGQVKQVKVLGVMALLDEEETDWKVIVIDVNDPLAPKLNDVEDVERHLPGLLRATNEWFRIYKIPDGKPENQFAFTGECKNKTYAMDVVRECSEAWEKLITGKTAPGNIATTNLTVNHSASRVSPDQLPPLPQNQELPPAPIDASIDKWFFISGASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PFX6</accession>
    <name>A0AAN6PFX6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_36755</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854405">
        <property type="protein sequence ID" value="KAK4039270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043032669" evidence="2">
        <location>
            <begin position="21"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4039270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="129" mass="14273" checksum="8BA74B6FA9AD7611" modified="2024-10-02" version="1">MHLNTILLLIPAILSSGVNSAPVAHEDGHQHGAATTTSGAPIARDEGAAKRPITDTTWWYGYAQKREADEQKQAKRGATDNAWWYVYEGKREAAQQDVEKEAEGKAKRGATDKAWWYVYEGKRDAGAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PFY3</accession>
    <name>A0AAN6PFY3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_15832</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854380">
        <property type="protein sequence ID" value="KAK4040284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PFY3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4040284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="300" mass="33564" checksum="E83D56F1159708C2" modified="2024-10-02" version="1">MASIASRSAASPSVSASPASTLPTSVESKQDDDLLTIQFTNVQDLFDVINCATGDFLTVTHVSPSNFTEIERERERQRRRFRFRRYNSNRQTLLITIPTDLHEALHIGIYQGYRDQLVTSGKANSWRTIGTAIRRARQGHPGGNGGEGDSTGGPKLERGVKDAWPTLVVEAGVSESLSELHNDMRWWFSTSDHQVQIVLLAKFEHTRRAITLEKWEEEPYDTRPGATTTRHAAALQPVLRQTITITQDTTTDPVSYNVTRGALVLGFRLLFLRDPGPGEGDFILSIQELEDYAKNVWDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PFZ5</accession>
    <name>A0AAN6PFZ5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Splicing factor, Prp19-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_35973</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854386">
        <property type="protein sequence ID" value="KAK4040007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PFZ5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033194">
        <property type="entry name" value="MFAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009730">
        <property type="entry name" value="MFAP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15327">
        <property type="entry name" value="MICROFIBRIL-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06991">
        <property type="entry name" value="MFAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Micro-fibrillar-associated protein 1 C-terminal" evidence="2">
        <location>
            <begin position="134"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="160"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4040007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="499" mass="56832" checksum="41285D10518FC4E9" modified="2024-10-02" version="1">MPPQKRMTANPVKPARYRAGKAAPESSSESEGSGSEQEDEAEKKAPPRRTAPPPKFASAAGPGRIISRGDGAKINLKGVGVGDGEDEEARRQAAKVARLEAERKAKEEGFVTEGEEDSEEEGSEEESEEEEESSEEEEAPRRLMMRPKFIPKSQRQANGSATAATPSTTTTTQPPPPAEGDQEQDPEAAAEAARLKAADELVEEQIKKHIAARAAGRKHWEDDASDPEHEVDDTDDIDPEAEYAAWKLRELKRLRREREAIEAREKELAEIERRRNLTEEERRAEDDAHLAAQREEKEGRGKMAYMQKYFHKGAFYQDESKAAGLDKRDIAGARFADDVDRSLLPKALQMRDMTKIGKKGATRYRDLKSEDTGQWGRLDDGRGRGGFDRNVDERFQPDDRRGGWERTDDGAKGANAIPLGARKERPREDRDRDSGHRRDSDRHRDDRDSYRRRDDSRDRRRSRSRSPRPERGDRRKRSPSRERDRDRYESDKRRRVDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PG51</accession>
    <name>A0AAN6PG51_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6594 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_17571</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854432">
        <property type="protein sequence ID" value="KAK4038339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PG51"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046529">
        <property type="entry name" value="DUF6594"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34502:SF5">
        <property type="entry name" value="DUF6594 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34502">
        <property type="entry name" value="DUF6594 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20237">
        <property type="entry name" value="DUF6594"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="218"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6594" evidence="3">
        <location>
            <begin position="43"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6594" evidence="3">
        <location>
            <begin position="85"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4038339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="249" mass="27878" checksum="7817059F5D47B262" modified="2024-10-02" version="1">MELLQTQPKAVQADPPANWSSDQQPTPTANGSNGPPEYKPQNYHRLAEIMSKDKNFAIFRRFDELNMLHLMALQAEILELRELFLSQLSLIPGPKKSQLSELQDWLRDKKGGKNFLQVVEFFTWRDDDTSSYTTMNPPVSEGDTFTDFITYRMASIFNRLPGRWFRTGKIVDEEAGLRSYSDSKLDKTSNVIAVIVASTLPVLTIFVLNSVGSTTARIGWAVLFTAVFAGILGLFSSAKRAELFAATAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PGF7</accession>
    <name>A0AAN6PGF7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pyridoxal phosphate-dependent transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_17415</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854427">
        <property type="protein sequence ID" value="KAK4038504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PGF7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43713">
        <property type="entry name" value="GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43713:SF3">
        <property type="entry name" value="GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE 1, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4038504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="447" mass="48330" checksum="7531EFC4D547FAB5" modified="2024-10-02" version="1">MTSNPTPSPNEAAAQAALGAAEARFIANNPLSQAQHDLATSILPGGNTRTLLHTSPFPLSMKRGQDAYVWDVDNHKYLDFVGELSAGLLGHSHPTIQSTILSTLSTIGLSLGATTPHEHAHAAQLCARFHLARVRMTNSGTEANLHALAGARHHTGRRKVVVFSGGYHGAVLSFPDGRAAVNTVDKQDFVVVPRYNDLEVARAVIEGTEDLAAVLVEPMQGAGGCIPGTREFLVGVREAARRRGAVFILDEVMTSRLAPGGLGAEMGLEPDMVTLGKYLGGGLAFGAFGGREEVMRVYDPRVEGGLAHSGTFNNNTLVMCVGAKVLGEVYTPEVCVEFNNRGDRFRERLREAARGSRVSFTGRGSLIGLHFTEDGVEDIACGEDIKAQIKPDLRDLFWFEMLEAGFWTTRRGLLAMILGTPDEELDRFVEAVKGFLEKRRDIMALRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PGL0</accession>
    <name>A0AAN6PGL0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aspartate aminotransferase</fullName>
            <ecNumber evidence="7">2.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_35771</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:21824"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="EC" id="2.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3 7">Homodimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="7">In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.1" evidence="7"/>
    <dbReference type="EMBL" id="MU854381">
        <property type="protein sequence ID" value="KAK4040257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PGL0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004069">
        <property type="term" value="F:L-aspartate:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006532">
        <property type="term" value="P:aspartate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000064">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000001">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000796">
        <property type="entry name" value="Asp_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006719">
        <property type="entry name" value="PRK09257.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879:SF55">
        <property type="entry name" value="GLUTAMATE OXALOACETATE TRANSAMINASE 1, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00799">
        <property type="entry name" value="TRANSAMINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="8">
        <location>
            <begin position="36"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4040257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="419" mass="45683" checksum="285BB2038B038CE2" modified="2024-10-02" version="1">MASTSITSFPAEVVPQAPEDPLFGLMRAYKADSSPDKVDLGIGAYRDDNAKPWVLPVVKKADEILRNDPEANHEYLPIAGLAALTGKAAELLLGKAAPAIAEKRAASVQTISGTGAVHLGALFLAKFYKIQGSNRTVYVSNPTWANHHQIFTNVGLPIATYPYFSKETKGLDFDGMKAALEQAPNGSIILLHACAHNPTGVDPTPEQWREIASLMKAKKHFPFFDTAYQGFASGDLDRDAGAIRLFVEQGFELVIAQSFAKNFGLYGERAGCFHYVAPPSADAAGITTRVASQLAILQRSEISNPPIYGARIASIVLNDAALFAEWQENLRTMSGRIINMRNKLRAKLEELGTPGQWNHITDQIGMFSFTGLSEPQVLKLRSDYHIYMTKNGRISMAGLNSRNVDYVATAVDKVVREAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PGQ8</accession>
    <name>A0AAN6PGQ8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Pre-mRNA-splicing factor PRP46</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Pre-mRNA-processing protein 46</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">C8A01DRAFT_46818</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 11">Involved in pre-mRNA splicing and required for cell cycle progression at G2/M.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 11">Belongs to the WD repeat PRL1/PRL2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854392">
        <property type="protein sequence ID" value="KAK4039793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000012">
        <property type="entry name" value="Putative pleiotropic regulator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045241">
        <property type="entry name" value="Prp46/PLRG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022092">
        <property type="entry name" value="TMF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022091">
        <property type="entry name" value="TMF_TATA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19923:SF0">
        <property type="entry name" value="PLEIOTROPIC REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19923">
        <property type="entry name" value="WD40 REPEAT PROTEINPRL1/PRL2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12329">
        <property type="entry name" value="TMF_DNA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12325">
        <property type="entry name" value="TMF_TATA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 11" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 11" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="2 10 11" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="TATA element modulatory factor 1 TATA binding" evidence="14">
        <location>
            <begin position="749"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="1003"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="1045"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="1087"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="1129"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="1212"/>
            <end position="1252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="27"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="574"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="665"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="916"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="211"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="294"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="762"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="80"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="96"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="140"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="192"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="574"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="616"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="665"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="929"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="966"/>
            <end position="978"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00056150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU369036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF12325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK4039793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1310" mass="142901" checksum="B3BE030D52F55B2E" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PGX0</accession>
    <name>A0AAN6PGX0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_16968</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854413">
        <property type="protein sequence ID" value="KAK4039001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PGX0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006342">
        <property type="entry name" value="FkbM_mtfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052514">
        <property type="entry name" value="SAM-dependent_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01444">
        <property type="entry name" value="fkbM_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34203">
        <property type="entry name" value="METHYLTRANSFERASE, FKBM FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34203:SF15">
        <property type="entry name" value="SLL1173 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05050">
        <property type="entry name" value="Methyltransf_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase FkbM" evidence="2">
        <location>
            <begin position="66"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4039001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="278" mass="30627" checksum="29E806552B1833AE" modified="2024-10-02" version="1">MPSASLPGVAHPGTSTATPEPQLLELGPDLTVYIGAERDARFIYKEIYQDHCYDIAPLPPNPFIIDAGANIGLFTLYMKAKYPAARILAFEPAPLIFELYRRNLALHNVPAQDVDAYACALGSESAASKPLTYFPNAPGNSTFVPGEKDLLRKALPAEHYQRMIDRSSAGATQVGVPVERLSRFLDGYPDLARIDLLKVDVESWELDVLRGVDDRHWEMVRNVAVEVSELSGLRKDIEALLKSKGFSIERELAAWSYETAPTYTILGRRGDGLSNPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PGY6</accession>
    <name>A0AAN6PGY6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sm protein F</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">C8A01DRAFT_46109</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854374">
        <property type="protein sequence ID" value="KAK4040547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PGY6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034715">
        <property type="term" value="C:pICln-Sm protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01722">
        <property type="entry name" value="Sm_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016487">
        <property type="entry name" value="Lsm6/sSmF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034100">
        <property type="entry name" value="Sm_F"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021:SF0">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN F SNRNP-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006609">
        <property type="entry name" value="snRNP_SmF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 10" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="11">
        <location>
            <begin position="7"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR006609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK4040547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="92" mass="10356" checksum="F49ACCC2545DF950" modified="2024-10-02" version="1">MSFVPVNPRPFLQDLVNKDVVVRLKWGETEYKGRLVSIDSYMNIQLSNTEEFIDRKFTGALGQVLIRCNNVLYVTAADGKGGEGDRDTKMEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PH05</accession>
    <name>A0AAN6PH05_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_15382</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854369">
        <property type="protein sequence ID" value="KAK4040818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PH05"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4040818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="495" mass="55034" checksum="B6475C1AAB73B3D9" modified="2024-10-02" version="1">MWGPGGVSCIIRFICHIPSGMMGARSLTNYNYSMGLGDIYDVIPHGKTFIQGMGVVGYAGVFTLAWNFVMFGASPFCRGSLLGLIGVVDLVLTIILTAGVAMQGQFLPGSYEACNGASDWNNGTDGRNFFVVANATDSFGIYGPDSICHNMMENWVFAIVVIMFYMISGIINISLGFLGEPGTIAEPYSFGQYDIDHFSWLFKPVRLLFKPVHMLYRFLRGSSYISFRYMSKYLARNKEANRPTAKQSQEGGNPYEKSASEPQSLRLPMELVIMITKDLHWTDLANLGRTSRYLRTLFFGADNPAQVARDLRHFACKDGGPLINCAVCSIQTCVGCRTNVSVPHSEAFRHLTGCQAACSKCFFKNHCYGQQRPAQPGYGWNDRTSSDDSSSAQFRPSWGGRLISSSSGYRLAGSSQNQTYDEVCHTCAQLSRREMEEVRDAHNLREIQRQARTPTACYSCRRMLAADGVRWWVDPQTGRECQWHGHPGWARAGAS</sequence>
</entry>
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        </recommendedName>
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            <taxon>Pezizomycotina</taxon>
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        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854387">
        <property type="protein sequence ID" value="KAK4039960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PH74"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033370">
        <property type="entry name" value="COG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31658">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR31658:SF0">
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    </dbReference>
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        <property type="entry name" value="VPS51_Exo84_N"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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            <end position="721"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006653"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00020978"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4039960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="786" mass="85809" checksum="43830424F52FC9A9" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PHW6</accession>
    <name>A0AAN6PHW6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_34680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
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        <lineage>
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            <taxon>Ascomycota</taxon>
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            <taxon>Sordariomycetes</taxon>
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    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854360">
        <property type="protein sequence ID" value="KAK4041268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PHW6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043010462" evidence="2">
        <location>
            <begin position="23"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="281"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <begin position="325"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="362"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4041268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="459" mass="45507" checksum="AB1F43E9088B7EEC" modified="2024-10-02" version="1">MARAIHLLALLSLSSNFAPTLGHVNRAAMYGGPPLSLPGTTATVTTTQLFTVTVAGSSREIFYVPTTVTVYTGCPSPSELSSVSGLPLSTFSSHGPWLNATSTAGAPCTHGLPTSTSLPSNDSSSLGWNHTVSTSRPTLTGTAGTTIETVDPIGTSSVRWTNSTWTSASEPDSTSVITLTVTSSATVTVNATLTSGFPGPTAPSAGTGLGNNSTGSATSYQPSLTYQTTIPASSTGPTSANGTVSNSSTPFATSTWSLPPGWSISTVSPSMSTTGMPLNFTSSPSSSTSSPSIFTTETNDALFTNPPSLTSAWANMTVTSTGQWNTTTAAPNPTSTLDRPSSTAAVGGGGDDDDGEGGEYGGYSYPAPSSSSPSTTTSMAGGGTAIGVSSVEAVDPVVGVTSTGAATSSGNGVIVTTFATETRSGAGSPSSSATLSGGGEYGYGGYGGYGGYGYGDEGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PI82</accession>
    <name>A0AAN6PI82_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Protein phosphatase PP2A regulatory subunit B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_46148</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Phosphatase 2A affects a variety of biological processes in the cell such as transcription, cell cycle progression and cellular morphogenesis, and provides an initial identification of critical substrates for this phosphatase. The regulatory subunit may direct the catalytic subunit to distinct, albeit overlapping, subsets of substrates.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the phosphatase 2A regulatory subunit B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854375">
        <property type="protein sequence ID" value="KAK4040515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PI82"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010972">
        <property type="term" value="P:negative regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902531">
        <property type="term" value="P:regulation of intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000174">
        <property type="entry name" value="Protein phosphatase PP2A regulatory subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000189">
        <property type="entry name" value="Protein phosphatase PP2A regulatory subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000009">
        <property type="entry name" value="PP2A_PR55"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018067">
        <property type="entry name" value="PP2A_PR55_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11871">
        <property type="entry name" value="PROTEIN PHOSPHATASE PP2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037309">
        <property type="entry name" value="PP2A_PR55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00600">
        <property type="entry name" value="PP2APR55"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01024">
        <property type="entry name" value="PR55_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01025">
        <property type="entry name" value="PR55_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="405"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="409"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="427"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00055525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00067298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU331113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4040515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="480" mass="54247" checksum="A06D7F1DFFDEFD05" modified="2024-10-02" version="1">MVDAEANVPTWKFTQCFGDKGDVEDITEADIISTVEFDHTGNYLATGDKGGRVVLFERNETKKTCEYKFHTEFQSHEPEFDYLKSLEIEEKINKIKWCRRQNASHYLLSTNDKTIKLWKVFEKSLKVVAENNLSHDLTPANIAGGGGAPRPLPSSHFRNASDLKLPRLTHHDTVVAAVPRRTYANAHAYHINSISVNSDGETFISSDDLRINLWNLNIQDQSFNIVDIKPANMEELTEVITAAEFHPMSCNWFMYASSKGTIKLADMRESALCDQHAKMFEQEEDPSSRSFFSEIISSISDVRFSYDGRYILSRDYLTVKIWDVNMERQPIKTIPIHEHLRPRLCDTYENDSIFDKFEVVFSGDGKNVMTGSYNNNFMIYPSDPEQEVEVVLQADKSAFKAKKVGVPTPINSSTSPTANGKKGGSRAGSPAAPGQGQRMRKETDADQIDFNKKILHMSWHPFEDSIAIAATNNLFVFSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PI87</accession>
    <name>A0AAN6PI87_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_47046</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854399">
        <property type="protein sequence ID" value="KAK4039479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PI87"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43046">
        <property type="entry name" value="GDP-MANNOSE MANNOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43046:SF14">
        <property type="entry name" value="MUTT_NUDIX FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="22"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4039479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="171" mass="19026" checksum="D5F11B34CA2FBFEE" modified="2024-10-02" version="1">MAAPAFPAPKVIGTEKADVSYTDRQAVRVVAFNPNGDVAIVYAKRDNYYKLPGGGIEPHEDHETAARREFQEETGGVIKLRSSNCMATTKEFRFHLRQVSYCYVADLVDDTGEPNLSDEEIEDGLGHLWVSVEEAKRLMAVAEPRSEFGRFVKERDIYLLDEATKGGAAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PIV4</accession>
    <name>A0AAN6PIV4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Family 3 putative carbohydrate esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_46784</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854391">
        <property type="protein sequence ID" value="KAK4039824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PIV4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01833">
        <property type="entry name" value="XynB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051532">
        <property type="entry name" value="Ester_Hydrolysis_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30383:SF2">
        <property type="entry name" value="CELLULOSE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30383">
        <property type="entry name" value="THIOESTERASE 1/PROTEASE 1/LYSOPHOSPHOLIPASE L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042825467" evidence="4">
        <location>
            <begin position="19"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="5">
        <location>
            <begin position="243"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4039824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="278" mass="29969" checksum="16A8B4C27610D315" modified="2024-10-02" version="1">MRLFAFTIVSGLVSATYAQKVRVMLLGDSITEITCWRPLVWNQITSAGLASSVDFVGSMSNLQGKCSRPSGFDPNHEGHSGWQAYDIARNNIVGWVQDTKPDIIQFMLGTNDVNIGKRNVQSILDSYTTMLNAMRAANPRVKVIIDKLIPTSWSDATVEGVNNAIPGWVQAHTTSQSPVVIADCSRAAGFTNAMLESDGVHPNNQGDQFLANQIGPKLIQLINDNIATLSTSTTSSLQPTGGNCAALYRQCGGQGYTGPTCCLQGTCKVSNDWYSQCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PJD1</accession>
    <name>A0AAN6PJD1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_15178</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854365">
        <property type="protein sequence ID" value="KAK4041040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PJD1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF17">
        <property type="entry name" value="O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005739">
        <property type="entry name" value="O-mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="5">
        <location>
            <begin position="114"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR005739-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4041040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="341" mass="37946" checksum="2D05AA49D14DB679" modified="2024-10-02" version="1" fragment="single">AIKTLIDAGVFKKWAEAGGNPITCTKLAELTGADVLLIRRMMRCISGQHLVTEVSLDTYARTPWAQALSDGPSFAGMYGGFYHELNNPMFRTLPSYPKETGFRNPTDVNNCNFQFWRGEGANMFQYVGTNPKLTSDFNDAMECHSKYNLTPWVDIYPTDGVVETAREGRPLVVDIGGGKGHDLKKFLARHCDAPLPPGSLVLQDLPEILKDIDVPQDGGTIAVQPHDFFTPQRDSARGARIYFMHNVLHDWPDATARQILQTLAPAMEKGYSRLLLHESLASSERPLSRVTVSDITMMACLAAAERSEEQWRELIPSAGLRIVKIWRPVESVESIIEVEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PK03</accession>
    <name>A0AAN6PK03_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_33645</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854343">
        <property type="protein sequence ID" value="KAK4042296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PK03"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4042296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="250" mass="27135" checksum="7F30D81CA8E74C68" modified="2024-10-02" version="1">MAEPLKASQVMMEAPAPSVREQRIAEITAAQRTTHADLFRRGTCRRPGNPVPDRVAHYDFRLGTVFLSSGMGQTSSSLGALDLALVYPDPARLPEVFVDQLSNDPPPSAYSFSQGKGHCADEVDAENKADVRFTQTFPDAGRISFLSRELVVLDETPDSRFANFGDSGAVIRNGTAVMVGMVWGGIEPRRFDDGEAVVVGPNRWPLRLSAITLCLPMEPLLEAMQAEIDKNFPGETVKLSPLPNSFGSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PK44</accession>
    <name>A0AAN6PK44_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_15601</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854375">
        <property type="protein sequence ID" value="KAK4040514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PK44"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4040514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="318" mass="32974" checksum="1C313BC962103390" modified="2024-10-02" version="1">MEGEAARKEPKGKGKAVAASPDDAPGGGTAETTASGASLSRMAQSAASLLLSGPPRGGHGAGDEKGNSSQASEALARAGESSVQLRSNAARGETMKMGQTQEHIAQEEASFAAFLDSGSAPMLSDPSGMEDAWRSVVPGAATPRATGAMEPASRSIEEQEARDGADVAALLSSGGDLDQVFDHTDEPPAPNDLEALRKALFGEGADHGTSASISWDNVLNFIPEYLQAPTAPGIGLGDQLSSHLGTSDTGEAWQTWIGQWSHVLTSYQDEVWGDLGALVDESRAEIQRIEEAKPGEAPPKPTALLRLRAILGHLRGPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PK57</accession>
    <name>A0AAN6PK57_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cullin family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_36007</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the cullin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854387">
        <property type="protein sequence ID" value="KAK4039955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PK57"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000014">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000031">
        <property type="entry name" value="Ubiquitin ligase subunit CulD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Cullin family profile" evidence="7">
        <location>
            <begin position="560"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="14"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4039955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="949" mass="104260" checksum="E84F3CBE6204A25D" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PK65</accession>
    <name>A0AAN6PK65_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SH3b domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_44671</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854343">
        <property type="protein sequence ID" value="KAK4042287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PK65"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043024844" description="SH3b domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4042287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="245" mass="25800" checksum="3CD39F002286A7B6" modified="2024-10-02" version="1">MHLSLTALALAAAVPMVSAYPVKADSLNCRAGPGTSYDVVRKYKKGVDVKITCQTTGPSIEGDNLWDKTSDGCYVADFYIQTGTSGYVTDKCGDSSGGGDSGGDLPGLNAVQSKHARAIIGEAKKEGLGRQGCEAGIATAIVESNILIYANKKVPESLNYPHDAVGSDYDSVGIFQQRATFYPDIAADMDAARSAAQFFTEMKRVSGWKTMAVGTLCQKVQRSAYPDRYAEQVGKAGKICAAGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PKP2</accession>
    <name>A0AAN6PKP2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">D-arabinono-1,4-lactone oxidase</fullName>
            <ecNumber evidence="2">1.1.3.37</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">L-galactono-gamma-lactone oxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_34237</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; D-erythroascorbate biosynthesis; dehydro-D-arabinono-1,4-lactone from D-arabinose: step 2/2.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.3.37" evidence="2"/>
    <dbReference type="EMBL" id="MU854352">
        <property type="protein sequence ID" value="KAK4041745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PKP2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003885">
        <property type="term" value="F:D-arabinono-1,4-lactone oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007173">
        <property type="entry name" value="ALO_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010031">
        <property type="entry name" value="FAD_lactone_oxidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43762:SF1">
        <property type="entry name" value="D-ARABINONO-1,4-LACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43762">
        <property type="entry name" value="L-GULONOLACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04030">
        <property type="entry name" value="ALO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043012598" description="D-arabinono-1,4-lactone oxidase" evidence="5">
        <location>
            <begin position="22"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="34"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00033418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4041745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="513" mass="57837" checksum="EB57CD59F6B09A57" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PLF9</accession>
    <name>A0AAN6PLF9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_43892</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15421"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57560"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854331">
        <property type="protein sequence ID" value="KAK4043106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PLF9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035336">
        <property type="term" value="P:long-chain fatty-acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF83">
        <property type="entry name" value="ACYL-COA SYNTHETASE LONG-CHAIN, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="6">
        <location>
            <begin position="107"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00036813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4043106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="697" mass="75602" checksum="EA91DB6923AA06F9" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PLS7</accession>
    <name>A0AAN6PLS7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Heterokaryon incompatibility protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_14790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854357">
        <property type="protein sequence ID" value="KAK4041429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PLS7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="23"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="2">
        <location>
            <begin position="226"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4041429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="595" mass="67422" checksum="591FEC31907BD10D" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PMD0</accession>
    <name>A0AAN6PMD0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ribonucleases P/MRP protein subunit POP1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_45190</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854352">
        <property type="protein sequence ID" value="KAK4041759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PMD0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039182">
        <property type="entry name" value="Pop1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055079">
        <property type="entry name" value="POP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009723">
        <property type="entry name" value="Pop1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012590">
        <property type="entry name" value="POPLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22731">
        <property type="entry name" value="RIBONUCLEASES P/MRP PROTEIN SUBUNIT POP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22731:SF3">
        <property type="entry name" value="RIBONUCLEASES P_MRP PROTEIN SUBUNIT POP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22770">
        <property type="entry name" value="POP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06978">
        <property type="entry name" value="POP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08170">
        <property type="entry name" value="POPLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pop1 N-terminal" evidence="5">
        <location>
            <begin position="68"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="POPLD" evidence="6">
        <location>
            <begin position="553"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="domain" description="POP1 C-terminal" evidence="7">
        <location>
            <begin position="738"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="169"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="679"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="775"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="682"/>
            <end position="696"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4041759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="921" mass="101716" checksum="570842694913C1BB" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PMN8</accession>
    <name>A0AAN6PMN8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">C8A01DRAFT_13601</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">May be involved in the turnover of nuclear polyadenylated (pA+) RNA.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854335">
        <property type="protein sequence ID" value="KAK4042840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PMN8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12257">
        <property type="entry name" value="RRM1_RBM26_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22249">
        <property type="entry name" value="UDM1_RNF168_RNF169-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1390.10:FF:000007">
        <property type="entry name" value="CCCH zinc finger and RRM domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000647">
        <property type="entry name" value="CCCH zinc finger and RRM domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1390.10">
        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002483">
        <property type="entry name" value="PWI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045137">
        <property type="entry name" value="RBM26/27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14398">
        <property type="entry name" value="RNA RECOGNITION RRM/RNP DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14398:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN SWM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01480">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="10">
        <location>
            <begin position="235"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="368"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="7">
        <location>
            <begin position="235"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="104"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="319"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="448"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="533"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="594"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="717"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="183"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="337"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="485"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="601"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="717"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="762"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="789"/>
            <end position="798"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00043866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK4042840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="840" mass="91993" checksum="399890AD9C54CE0E" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PN18</accession>
    <name>A0AAN6PN18_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_31931</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854323">
        <property type="protein sequence ID" value="KAK4043832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PN18"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04165">
        <property type="entry name" value="GTPBP1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03694">
        <property type="entry name" value="GTPBP_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03708">
        <property type="entry name" value="GTPBP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000014">
        <property type="entry name" value="Probable GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000091">
        <property type="entry name" value="Probable GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050055">
        <property type="entry name" value="EF-Tu_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035531">
        <property type="entry name" value="GTPBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721">
        <property type="entry name" value="ELONGATION FACTOR TU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721:SF9">
        <property type="entry name" value="GTP-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="5">
        <location>
            <begin position="192"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="609"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4043832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="652" mass="70837" checksum="CF788029736B6FA4" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PN70</accession>
    <name>A0AAN6PN70_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquitin-conjugating enzyme E2 2</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">E2 ubiquitin-conjugating enzyme 11</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">E2 ubiquitin-conjugating enzyme 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Ubiquitin carrier protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Ubiquitin carrier protein UBC2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Ubiquitin-protein ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Ubiquitin-protein ligase UBC2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">C8A01DRAFT_14121</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="14">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
    <dbReference type="EMBL" id="MU854344">
        <property type="protein sequence ID" value="KAK4042224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PN70"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23791">
        <property type="entry name" value="UBCc_UBE2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000068">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2-20 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 14" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="16">
        <location>
            <begin position="32"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="13">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00042179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00042190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00080142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAK4042224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="180" mass="19586" checksum="2AF5FA73E9A94122" modified="2024-10-02" version="1">MSFAEDSQNSAPGSVPANKLGGARKGAEPGLNAAKRLQTELMQLMTSPAPGVSAFPSADGNLLSWRATIEGPDDTPYSGLTFKLSFEFPSNYPYAPPTVLFRTPIYHPNVDFSGRICLDILKDKWTAAYNIQTVLLSLQSLLGEPNNASPLNGEAAELWDKDPALFKTKVMDRHKDVEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PP97</accession>
    <name>A0AAN6PP97_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phenylalanine--tRNA ligase alpha subunit</fullName>
            <ecNumber evidence="5">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Phenylalanyl-tRNA synthetase alpha subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">C8A01DRAFT_31222</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>tRNA(Phe) + L-phenylalanine + ATP = L-phenylalanyl-tRNA(Phe) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="5"/>
    <dbReference type="EMBL" id="MU854317">
        <property type="protein sequence ID" value="KAK4044724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PP97"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009328">
        <property type="term" value="C:phenylalanine-tRNA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00496">
        <property type="entry name" value="PheRS_alpha_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2330:FF:000002">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000028">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004529">
        <property type="entry name" value="Phe-tRNA-synth_IIc_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040725">
        <property type="entry name" value="PheRS_DBD3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00468">
        <property type="entry name" value="pheS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003210">
        <property type="entry name" value="PRK04172.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF40">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18553">
        <property type="entry name" value="PheRS_DBD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 18" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0436">Ligase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="17">
        <location>
            <begin position="229"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAK4044724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="512" mass="57629" checksum="FD22F0141ACA22C0" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PPD4</accession>
    <name>A0AAN6PPD4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_44824</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854345">
        <property type="protein sequence ID" value="KAK4042175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PPD4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF137">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="19"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4042175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="392" mass="43537" checksum="9D2CB47F460A95AC" modified="2024-10-02" version="1">MDVYDEVVRWAQDQGVELDGVAPRSLPGRGVGIVATRPLEANQRILHVPASVLRTLDTVRPQVKEALPKDTKVHAILAAELALDKPTSEYSPWNAVVPSRDSVSASLPLAWDARLHPYLPKPALALLRKQQAKFTRDWTAIQQTPLAAAATSQSTTPTITRQEYLHFWLLVNTRTFYHETPHTATLPRDDRMVLQPVADLFNHADTGCAVAFTGAGGGGGSGFTVTADRPYAAGEEVYICYGKHTNDFLLVEYGFVLETQNRWDEVCLDEAVLPALSGARRELLDERGFLGNYVLDAGTVCYRTQVAVRLLCVSAGEWERLVHEGEDGGEALQEEVDRLLVGMLRRYRGTVEGRVQEIEGLEVGLPSQREVLCTRWRQIGRLVEQTIERLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PPV1</accession>
    <name>A0AAN6PPV1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">R3H domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">C8A01DRAFT_13962</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NFX1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854341">
        <property type="protein sequence ID" value="KAK4042415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PPV1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06008">
        <property type="entry name" value="NF-X1-zinc-finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="CDD" id="cd06006">
        <property type="entry name" value="R3H_unknown_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16492">
        <property type="entry name" value="RING-CH-C4HC3_NFX1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.50:FF:000006">
        <property type="entry name" value="NF-X1 finger transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034078">
        <property type="entry name" value="NFX1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034077">
        <property type="entry name" value="R3H_FAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000967">
        <property type="entry name" value="Znf_NFX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12360">
        <property type="entry name" value="NUCLEAR TRANSCRIPTION FACTOR, X-BOX BINDING 1 NFX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12360:SF12">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR NF-X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01422">
        <property type="entry name" value="zf-NF-X1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00393">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00438">
        <property type="entry name" value="ZnF_NFX"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="R3H" evidence="11">
        <location>
            <begin position="825"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1130"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1196"/>
            <end position="1219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK4042415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1232" mass="133360" checksum="D653CC6855572644" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PPX6</accession>
    <name>A0AAN6PPX6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_31943</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854323">
        <property type="protein sequence ID" value="KAK4043843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PPX6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4043843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="333" mass="37091" checksum="2F91FE541E3018D2" modified="2024-10-02" version="1">MPTYYTPPQTPITTPSSSSSSCPSRSNSFSHAPSTGRRSDATPSSSSSSNNNRSRLSKLGLGKHDEADAEKKTKIPYFFLGSIAAASLLAHKCWPRGYSYGDKEDWELSGLALRAKQRRLAEKAEKAEKAARWAGGGSRRGSSSGGGLGPAEYSGYELYREERRGRGGGHYLGEGEEDRYRRDDRGPWDWESGGRERRGSVISRGRRMSRGPDRDYSADRYLEPSYRRATNRERTELLATTDRYYPPASKRYLMEQSASAAGSSSSGSRYLLEGSSSNAGSRFPGSSQQRYYEQVRPGEVVYIYRDPPARSRRASFDAGGVRRHDGEFGWYDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PR45</accession>
    <name>A0AAN6PR45_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_42604</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854317">
        <property type="protein sequence ID" value="KAK4044700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PR45"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021838">
        <property type="entry name" value="DUF3431"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37490:SF3">
        <property type="entry name" value="DUF3431 DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37490">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11913">
        <property type="entry name" value="DUF3431"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4044700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="326" mass="36854" checksum="BA0A0C811C7E4CAA" modified="2024-10-02" version="1">MLARSARARGSVIPILILVACSWLLVLHTHIQRDWFPFAKEPPVEVVVASLSTEDTAWVHRYLPGWARSVYVVDDPSARLTVPQNKGREAMVYLTHLIANYDTLAETTVFIHASRFAWHNDDPDYDSLPALRRLNLDYVRDSGYVNLRCVQVLGCPVEIRPHADAASAWERSIGAAAGSGSGSGVSRPLTAKEIYKQAFEELMPGVEVPQRVGVSCCSQFAVSREAVLSRPREDYIRWRDWLLETPLEDDLSGRVFEYMWHMIFGKEAVFCPSASECYCKLFGLCDLQCEEMQCEGRYILPKYSNLPEGWPRLGYSGEERNFTGPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PT42</accession>
    <name>A0AAN6PT42_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Isocitrate dehydrogenase [NAD] subunit 1, mitochondrial</fullName>
            <ecNumber evidence="5">1.1.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Isocitric dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">NAD(+)-specific ICDH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">C8A01DRAFT_31409</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-threo-isocitrate + NAD(+) = 2-oxoglutarate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:23632"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.41"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Octamer of two non-identical subunits IDH1 and IDH2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.41" evidence="5"/>
    <dbReference type="EMBL" id="MU854319">
        <property type="protein sequence ID" value="KAK4044356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PT42"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004449">
        <property type="term" value="F:isocitrate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000001">
        <property type="entry name" value="Isocitrate dehydrogenase [NAD] subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004434">
        <property type="entry name" value="Isocitrate_DH_NAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00175">
        <property type="entry name" value="mito_nad_idh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835">
        <property type="entry name" value="DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835:SF42">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NAD] SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="13">
        <location>
            <begin position="56"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00071938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK4044356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="393" mass="42711" checksum="78CBBE9701950DCB" modified="2024-10-02" version="1">MLSRNSTRTAQRLLRAAAQPQQRLNAARGFASVSDAPAQTVQSDIFKPTKYGGKYTVTLIPGDGIGAEVAESVKTVFKADNVPITWEQIDVSGLQDATPTGRTEERFQEAVASLRRNKLGLKGILHTPISRSGHQSFNVALRQELDIYASVSLIKNIPGLKTRHDNIDLCIIRENTEGEYSGLEHQSVPGVVESLKIITRAKSERIAKFAFSFALANNRKKVTCIHKANIMKLADGLFRGTFNRLAKDYPQLECNDMIVDNASMQCVGRPQQFDVMVMPNLYGGILSNIAAALVGGPGVVPGCNMGRDVAVFEPGCRHVGLDIKGKDQANPTALLLSGTMLLRHLGLDDHANRISNAVYDVIAQGNVRTPDMGGQATNQEFTRAILASMEKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SLL9</accession>
    <name>A0AAN6SLL9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">lytic cellulose monooxygenase (C4-dehydrogenating)</fullName>
            <ecNumber evidence="15">1.14.99.56</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">C8A01DRAFT_41936</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the polysaccharide monooxygenase AA9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="15"/>
    <dbReference type="EMBL" id="MU854746">
        <property type="protein sequence ID" value="KAK4031620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SLL9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF2">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042812363" description="lytic cellulose monooxygenase (C4-dehydrogenating)" evidence="17">
        <location>
            <begin position="19"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="18">
        <location>
            <begin position="253"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="223"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="225"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAK4031620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="288" mass="30512" checksum="59A046F31AF5F8E7" modified="2024-10-02" version="1">MKFSSLAVGVIAAQGVSAHYWSDTNLINNAAQPAYKYVRESTRATKYNPIKFSSNPAADLRDGSTINGPDSRCNQGAFSSAGRTSVLTVNAGDEIRLRLAAGAKFQPPDWFKIYEEGVCNQGADFTSSAWCDYDRNWLAAKIPKDTPNGEYLARFEHIGVHRCHVNQPEHYVSCLQVKVVNGGSGSPGPTVKFPGAYKNTDAYANFSIYNGFKNFPMPGPAVWSGGSGGNSGGGSSPQPQPQPTAGNGNSGTGCAALYGQCGGRDFTGAKCCASGTCKAANEWYSQCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SMA0</accession>
    <name>A0AAN6SMA0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_20409</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854600">
        <property type="protein sequence ID" value="KAK4032518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SMA0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000106">
        <property type="entry name" value="MFS transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF65">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="362"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="399"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="425"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="489"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="524"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4032518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="582" mass="66698" checksum="5D8FA95FE7E42E01" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SMM3</accession>
    <name>A0AAN6SMM3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RecQ-mediated genome instability protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_20083</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RMI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854565">
        <property type="protein sequence ID" value="KAK4032907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SMM3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031422">
        <property type="term" value="C:RecQ family helicase-topoisomerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.770">
        <property type="entry name" value="RecQ-mediated genome instability protein Rmi1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049363">
        <property type="entry name" value="RMI1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042470">
        <property type="entry name" value="RMI1_N_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013894">
        <property type="entry name" value="RMI1_OB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14790:SF15">
        <property type="entry name" value="RECQ-MEDIATED GENOME INSTABILITY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14790">
        <property type="entry name" value="RECQ-MEDIATED GENOME INSTABILITY PROTEIN 1 RMI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08585">
        <property type="entry name" value="RMI1_N_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21000">
        <property type="entry name" value="RMI1_N_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RMI1 N-terminal" evidence="5">
        <location>
            <begin position="12"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="RecQ mediated genome instability protein 1 OB-fold" evidence="4">
        <location>
            <begin position="69"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="113"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="113"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="135"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="148"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF21000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4032907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="258" mass="27612" checksum="7F1F65BE4D9EE091" modified="2024-10-02" version="1">MDIPHQLHTSLSTTTTPLPSLPWLTSLTTSRHPPPPLASLLATARTRLLCSDLTTPNLLDPQYAATHTLPPHLQQTHAATRETKLAQDVVVQVLDIEDISRSTWEQVEELEAVARGEGTRGREVVRLPTSTNNGNGAGEDGEGGVGEGTQDPGQGQAQQQQSGGGSSKNSTHKLVVQDCKGQKVHAIELKRVERLAVGKTFIGEKILLRAGTVVARGAVLLDPALCVVLGGKVEAWHRAWVDGRLARLREAAGAERRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SMP7</accession>
    <name>A0AAN6SMP7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidase signature domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_50407</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854564">
        <property type="protein sequence ID" value="KAK4032923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SMP7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42678">
        <property type="entry name" value="AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42678:SF34">
        <property type="entry name" value="OS04G0183300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="22"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4032923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="502" mass="54132" checksum="468BEB4517C11B28" modified="2024-10-02" version="1">MDATLDDLVRGLARGHFTSAHLVQAYVARVAEVNDVFHAVIELGPDAEAIARALDQERLERGPRSALHGMPCLLKDNIVTLDKTQATCGSAALLGTAPAAEAGIATILRKAGAVLLGRTNLSEFAGFRGGQATGIFWPNMKASCSSTGSAISVGLGLAFASFGTETVSSLVSPSEKSCVVGLKPTRGLLPTDGMIPVSNRQDALGHIARTVKDVAQILDVVVQFDPRPTAHYSKPTYAESCAAVDLQGVRIGVVEHPGQDIDQPKTNAFRETHGMLTAAGATILGGVRLGGLQEYDLLPQRMKTIVLETEFKADMEAYILSLTKNPRRILTLKDLVDTIQSEQLEEYPARDVEMMLRALDTSKSAPDYTTMLRKEEYYANSGGFEGAMDRHDCDVLIAPAGSLALQAFAAVGGNPAMSVPMGFYPEGTKIRRDEMRGGLVSVAPGIPFSLYLYGRRHGKSQLLRVPYVFEQLCGAQKRAKPYFLPETDLEDIVFSNRKARHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SN16</accession>
    <name>A0AAN6SN16_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TauD/TfdA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_19871</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854549">
        <property type="protein sequence ID" value="KAK4033150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SN16"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052973">
        <property type="entry name" value="Fungal_sec-metab_reg_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35392:SF3">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35392">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="3">
        <location>
            <begin position="808"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="146"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="331"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="152"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="166"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="334"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4033150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1107" mass="124265" checksum="B5FF57074491318A" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SNT7</accession>
    <name>A0AAN6SNT7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_19163</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854501">
        <property type="protein sequence ID" value="KAK4033975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SNT7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF6">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4033975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="648" mass="74026" checksum="E0736E55876FE7E4" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SP32</accession>
    <name>A0AAN6SP32_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protoheme IX farnesyltransferase, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Heme O synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">C8A01DRAFT_39208</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Converts protoheme IX and farnesyl diphosphate to heme O.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UbiA prenyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854484">
        <property type="protein sequence ID" value="KAK4034333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SP32"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008495">
        <property type="term" value="F:protoheme IX farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006784">
        <property type="term" value="P:heme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13957">
        <property type="entry name" value="PT_UbiA_Cox10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.140:FF:000004">
        <property type="entry name" value="Protoheme IX farnesyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006369">
        <property type="entry name" value="Protohaem_IX_farnesylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030470">
        <property type="entry name" value="UbiA_prenylTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01473">
        <property type="entry name" value="cyoE_ctaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43448">
        <property type="entry name" value="PROTOHEME IX FARNESYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43448:SF2">
        <property type="entry name" value="PROTOHEME IX FARNESYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00943">
        <property type="entry name" value="UBIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="289"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="409"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="458"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="104"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="491"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="104"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="137"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="492"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="513"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK4034333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="530" mass="56322" checksum="8F92FBAD3738F897" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SPD4</accession>
    <name>A0AAN6SPD4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">C8A01DRAFT_48611</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SUN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854453">
        <property type="protein sequence ID" value="KAK4035174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SPD4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051526">
        <property type="entry name" value="Beta-Glucosidase_SUN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005556">
        <property type="entry name" value="SUN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31316">
        <property type="entry name" value="BETA-GLUCOSIDASE-LIKE PROTEIN NCA3, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31316:SF0">
        <property type="entry name" value="SECRETED BETA-GLUCOSIDASE SIM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03856">
        <property type="entry name" value="SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0134">Cell wall</keyword>
    <keyword evidence="9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="114"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK4035174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="421" mass="44156" checksum="C7C9C0090FEF6258" modified="2024-10-02" version="1">MKGIIKTAVAAAVVAGVAAQPHNHGHRHLHAKKHDHSRVERRDGTVIVTEVVEGPTVIEYVMPDGQKVDAAKAESLLDKGLYVVLGETKPSFSAPPPAVTTSLALPEFGGKFFEKSTSTAPTTTSTPPASSSAAPSSAPNGPTGLDADFPSGQVSCDHVPTEYGALAVPWTGTNGWTTLAKFGGWIKGVAINNIESPTSGGCEPGMMCSYACPPGYQKTQWPAEQGATGQSVGGLWCNDDNMLELTRPNATKICEPGAGGVYVRNELSSNAAVCRTDYPGNEGMVVPLDTSPGNTYPVTNPDSKTYYWWQGTATTAQYYINNAGVEVEEACTWKSSKFPLSAGNWAPTNLGVGKSVAGETYISLFPNLPTSNAVLDFDVEITGDISGTCYLKKGQYYGSDKGCTVGMKAGGTATIVFKHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SPF3</accession>
    <name>A0AAN6SPF3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_48822</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854462">
        <property type="protein sequence ID" value="KAK4034872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SPF3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409:SF356">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409">
        <property type="entry name" value="ZINC FINGER PROTEIN 142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="32"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="103"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4034872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="288" mass="32916" checksum="B937F42EAF0C8C5D" modified="2024-10-02" version="1">MYECGTCGKEFYAGWQARDNHCRSTGHRAPEFECDTCDRYFASEQSCLQHMDAKNHHFNDDHESSEYSSESSDESYEEWCCDMCSEYFDTEEKCHRHEIVEHFYCSDCGRSFVNYKGIKNHLDSSLHSDRVVKCPLCTHSDANASAIAMHIERGWCPGAPNMDRDEMYRMVRSKDPKDRISRRSIFGDLAGAAPVKFAASETAWTGKGYECYFCHEKFGSLNGLNCHLNSDTHQEVLYHCPKSSCPSEFKTLAAVINHLESETCGAMRFDTVQRRIGDIVSGNRLLCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SQ44</accession>
    <name>A0AAN6SQ44_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_17827</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854442">
        <property type="protein sequence ID" value="KAK4038031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SQ44"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043053706" evidence="1">
        <location>
            <begin position="22"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4038031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="160" mass="17160" checksum="A7A44A7DB4923749" modified="2024-10-02" version="1">MLPQLSSLLAIPALLAATALAAPALEVPAVLDPRQAACPTTSRWQSYSYSTVWRSTTTVTNGWSSLGSVTSTKTEKETRTINTRTTVYSPAVTTLPATTTSPRVDANETVTVTWFTYHETVSSPGFAPPSLCQVTTVTNVIPSTTHITYTQDLSYDLLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SQ68</accession>
    <name>A0AAN6SQ68_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_36992</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854412">
        <property type="protein sequence ID" value="KAK4039019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SQ68"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4039019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="101" mass="10673" checksum="DA5F473E08A6CBC7" modified="2024-10-02" version="1" fragment="single">MALSSILWQNDRKTVVLLDLPRSIEEAQVPSSQLTAHNEDEPPAKLRRLISALPPASPFPTPEPKAGGSEPPAASPSAQVAELMTQAAVESALAEIKASHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SQG5</accession>
    <name>A0AAN6SQG5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_36685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854403">
        <property type="protein sequence ID" value="KAK4039319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SQG5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="288"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4039319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="432" mass="46615" checksum="C214E55154842EBE" modified="2024-10-02" version="1">MERESRRLTLTLLIFEATDGETTLTDDVTNRFAGPFQGSAWHSKVRKIAGAGSAGGTGGTTGSTASSVIPSHYELQLVHRTLATGYGPAVQQETRAAIETLCQDFCDPEGALSPRRINPNPTIIFTVAVDPNNPTDETFLETFVKHSVQNTNGRVDLGLKDPAPSSITQVVSFGAPFKGILQSLPGALAGDQNDLVVVAGLVPAVLQLMPHILQENNAEHRALTEQTMASIDMAMSSFGELENCTRSSAQLQSAKQHLGHLRDAMSALARQHEGAKDQQQSALKTQRLLLLTAVATLVTVLLVPTVGTALADTAPAAAQFITRGWDGCVELWRLAIRDKGGDGQKDEQALRKTDESIHRWLFVMLLDVLGSDYRHHPGPAGVAKLAMEMAAVVEPEALAGWDYRTSTRETQNRYLKDLLEHWTRSAAGPPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SQK3</accession>
    <name>A0AAN6SQK3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_17511</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="MU854430">
        <property type="protein sequence ID" value="KAK4038408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SQK3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042662132" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="19"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="31"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="370"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4038408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="497" mass="53733" checksum="BB3A40D2EAF72ED9" modified="2024-10-02" version="1">MRFQILASSILLAPLAGARDTCSEGPKSGLTIKTTSGTYTGLVNSSAPDVNQWLGIPYGRPPVGARRFMPPEKAPDYGTADAKAYKPICLQSSGSKTSVFWQLMPEFQNTDPQSEDCLYLNIWGPRRPVQKKVPVIIWVCGGGFKEGGGHAPYQVPDQWIQRTQTHIVVTFNYRLSVFGFPGSPAANKNAGLMDIRLVTEWLKDNIAEFGGDPNRMILYGQSAGSNAVLTYAYAYPEKPIVRGFIASSGGTSTTNPTNSSLFHELAQTAGCANLTATAELACMQNVDRQVLQQKVDEASTDPNRGLFRPIADNITVFANLTDRLEKGLVAKLPLIAGFTYNEAAAFLPFDPDATTAPNGTADPGTGGLACGAKREILTRSAYGLTTYGYLYSGNFSNITPRYWLGGMHSSDIPLVFGTHSQFRGNSTELEWQTSYAMEAFWVSFAANPSAAPRDHYGQTWPKYTEASRQIVVFGNATGPSASYIAPVAIADKYSGPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SQN1</accession>
    <name>A0AAN6SQN1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Reticulocyte-binding protein 2 a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_17417</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854427">
        <property type="protein sequence ID" value="KAK4038498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SQN1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="155"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="198"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="155"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4038498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="493" mass="55449" checksum="15B37F3E6571B1B1" modified="2024-10-02" version="1">MAAIWDPERLLDIRGSAMFHGGIQCHGANGGYGPRCRWTKGRRDDERPDVREADALLQTMATQPPSNVTAQSLQRLAELCLCRDHHWNDRQRDTVAGAWAELIRQAVSRYASTPAPVPVHVPVPVPVPTTPLVATPQFNQAQWQSTNWHTTLASQVGSVADSSSSQSTNGAQHQHADAPAGLTWSRRSPSRERTESELTATLARLSALQIQNEDLRKQEQRLKALDSEYSEFRDRTETQLAVRRTELAALQGENRDLQQEEQRLRALHVEHSRSSQRTSEALAATQKQLSTLQIENKNLLEQQDRLKTLESEYSSFKARSEAELRAAAEKLAQALADKEQLRAEKDMDVGRKAVAGGEYRALEQKERETSARLRQRDADLQALADRHRALEQTERNMQALVQHQHAELHRLRTWKQQAEVAESKRGLDAAAQQRGAEPRDALRLRSDAGVAAVPQEPEVVVVTARPGSGSGERTPRPWARRVRGLFKRLRHRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SQR7</accession>
    <name>A0AAN6SQR7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_37457</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854424">
        <property type="protein sequence ID" value="KAK4038618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SQR7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042822231" evidence="1">
        <location>
            <begin position="18"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4038618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="106" mass="11247" checksum="F23C37CD203B4D90" modified="2024-10-02" version="1">MRASSILSVAFIGLASAALPKANEYKSGDCSGAMNYEHHSALLSHVTMDDTTHSVYITGNFIGYTGKTGNGGSCTGEALIIMNHACNNLDTVYPGKRIKCLRYVGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SQX0</accession>
    <name>A0AAN6SQX0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_17170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854419">
        <property type="protein sequence ID" value="KAK4038768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SQX0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018555">
        <property type="entry name" value="C630.06c-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09428">
        <property type="entry name" value="DUF2011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4038768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="290" mass="31831" checksum="D31BBD271286748D" modified="2024-10-02" version="1">MFLPPSISPQPTADQVHRVRRQDLYDSSSERHSSPEAENEETAELRAKLNARLSNLLSLDLGTAAAAGPEPTNEPHPTAADGDGDGEAQDQGEAEFEFRLFSTSTAAAPKVVLAPDDAEARYDGPALSQRPVSHYIRGELSAEERERFRRAAVTGQDVLAWAGQRAWGLEVPWRVTKITVVAARGKGATVGGQQLQQPQGDVMDKKKKRPGKKRRIVLRKRDKAKKEAETAAAKQKMSKEEHLKEKKKRLNREKKLKRRQKEKEKKAAKGAAGGEEVAGGSGSEGSDREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SR55</accession>
    <name>A0AAN6SR55_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phospholipid/glycerol acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_16761</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854406">
        <property type="protein sequence ID" value="KAK4039245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SR55"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004366">
        <property type="term" value="F:glycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016287">
        <property type="term" value="F:glycerone-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052744">
        <property type="entry name" value="GPAT/DAPAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31605">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31605:SF0">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="446"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="497"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="532"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="3">
        <location>
            <begin position="63"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="631"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="737"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="637"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="665"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="690"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="737"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="770"/>
            <end position="780"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4039245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="789" mass="86580" checksum="836F0C6A041BEA06" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SR68</accession>
    <name>A0AAN6SR68_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_46541</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854385">
        <property type="protein sequence ID" value="KAK4040054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SR68"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030621">
        <property type="term" value="F:U4 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20546">
        <property type="entry name" value="CYCLIN_SpCG1C_ScCTK2-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000072">
        <property type="entry name" value="Cyclin Pch1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.110:FF:000003">
        <property type="entry name" value="Pre-mRNA splicing factor, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000698">
        <property type="entry name" value="Putative pre-mRNA splicing factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.110">
        <property type="entry name" value="Pre-mRNA processing factor 4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014906">
        <property type="entry name" value="PRP4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036285">
        <property type="entry name" value="PRP4-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19846:SF0">
        <property type="entry name" value="PRE-MRNA PROCESSING FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19846">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08799">
        <property type="entry name" value="PRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00500">
        <property type="entry name" value="SFM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158230">
        <property type="entry name" value="PRP4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Pre-mRNA processing factor 4 (PRP4)-like" evidence="7">
        <location>
            <begin position="63"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="289"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="331"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="377"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="484"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="6">
        <location>
            <begin position="639"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="515"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="848"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="981"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="109"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="588"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="873"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="910"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="948"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="988"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1004"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1023"/>
            <end position="1035"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4040054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1035" mass="114149" checksum="ADB980821E0949E6" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SR80</accession>
    <name>A0AAN6SR80_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tropinone reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_46938</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854396">
        <property type="protein sequence ID" value="KAK4039607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SR80"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF122">
        <property type="entry name" value="NAD(P)-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4039607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="293" mass="31044" checksum="2AAA366115BEE81C" modified="2024-10-02" version="1">MSRDGSRYGSCPEYIPSIPTTYQYGTSIVTGAGSHGSENDLGNGSATAILLAESGAAVLCVDKHLSLAEHTASIINNNTTTPGQAIAVEADVTNPTDCKQITDYALTTFGTLDILINVVGVMGARGTAVDVDLDEWNKGMEINVTSMMLMAKYAIPAMLRNRRTEGQPVRGSIVNVGSVAGLRGGTPHLLYPTSKGAVVNMTRAMAAQHGREGVRVNCVCPGMLYTPMMYRQGMSEEMREKRKQRSLLGTEGNVWDCAHAIRFLAGDEARWITGAVLTVDAGATAATSLSPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SRD0</accession>
    <name>A0AAN6SRD0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_16337</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854393">
        <property type="protein sequence ID" value="KAK4039757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SRD0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF18">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4039757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="623" mass="67852" checksum="9845C03FF812C791" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SRR9</accession>
    <name>A0AAN6SRR9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Kinetochore protein Sos7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_46001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854371">
        <property type="protein sequence ID" value="KAK4040714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SRR9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034501">
        <property type="term" value="P:protein localization to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037475">
        <property type="entry name" value="Sos7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048781">
        <property type="entry name" value="Sos7_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37329">
        <property type="entry name" value="KINETOCHORE PROTEIN SOS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37329:SF1">
        <property type="entry name" value="KINETOCHORE PROTEIN SOS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20882">
        <property type="entry name" value="Sos7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinetochore protein Sos7 coiled-coil" evidence="3">
        <location>
            <begin position="95"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="44"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="130"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="53"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4040714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SRV3</accession>
    <name>A0AAN6SRV3_9PEZI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_36279</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854393">
        <property type="protein sequence ID" value="KAK4039743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SRV3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039535">
        <property type="entry name" value="ASST-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14269">
        <property type="entry name" value="Arylsulfotran_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4039743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="102" mass="11072" checksum="BEBD3D17E72478AB" modified="2024-10-02" version="1">MSVARVIFANDMDAKDMDTSGNYFSGTDGSIVWRSIGKLSNFTVPSNAKFCFQHDAHWLSQHDDNEIISLYIARAGSATAIATDPSEVIDAGVKGKELSKMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SRX3</accession>
    <name>A0AAN6SRX3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ankyrin repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_46325</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854379">
        <property type="protein sequence ID" value="KAK4040342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031359">
        <property type="entry name" value="NACHT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17100">
        <property type="entry name" value="NACHT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
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        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="363"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="966"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1124"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1269"/>
            <end position="1301"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1302"/>
            <end position="1335"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4040342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1560" mass="170928" checksum="FDB4090A573E5FD9" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SRZ1</accession>
    <name>A0AAN6SRZ1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ankyrin repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_15960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854384">
        <property type="protein sequence ID" value="KAK4040115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SRZ1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="581"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="735"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="613"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4040115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="799" mass="89056" checksum="8178958EB81EAF8D" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SS20</accession>
    <name>A0AAN6SS20_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_35734</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854381">
        <property type="protein sequence ID" value="KAK4040220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SS20"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="142"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="207"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="227"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4040220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="238" mass="25802" checksum="433D2E6265232B1D" modified="2024-10-02" version="1">MVNGKWHERLRRVRNRVFRREDPPPPEATPPAPAPPDPPIFHTPTMPRRLNQPVFQLSSRQPTHYYPPSRLQDNLRGRAPNHAQPGITLPVPQSGTSATMQPLPGCLAAMSSAKTTPVPSAKTTPVPSAKTTPAPSYKAPRARQQQRQQQEQTSPPSSSPSSSAKTRSSSIRSSLLSFRSNRSRGRARLRISHPTCQSAPSLGGLNGQIKQNGQNGQSMHNGQNGQSSSTPSPTTPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SS86</accession>
    <name>A0AAN6SS86_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Metallo-dependent phosphatase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_46056</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the 5'-nucleotidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854372">
        <property type="protein sequence ID" value="KAK4040687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SS86"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07406">
        <property type="entry name" value="MPP_CG11883_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="entry name" value="5'-Nucleotidase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008334">
        <property type="entry name" value="5'-Nucleotdase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041821">
        <property type="entry name" value="CG11883_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575:SF48">
        <property type="entry name" value="5'-NUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="5'-NUCLEOTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02872">
        <property type="entry name" value="5_nucleotid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01607">
        <property type="entry name" value="APYRASEFAMLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="5">
        <location>
            <begin position="29"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="5'-Nucleotidase C-terminal" evidence="6">
        <location>
            <begin position="321"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="534"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="585"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4040687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="662" mass="72634" checksum="38C787CA759CB21C" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SSF8</accession>
    <name>A0AAN6SSF8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_35573</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854377">
        <property type="protein sequence ID" value="KAK4040431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SSF8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053018">
        <property type="entry name" value="Elsinochrome_Biosynth-Asso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37577">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37577:SF1">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="246"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4040431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="318" mass="34839" checksum="08CFA9BDDA82912B" modified="2024-10-02" version="1">MESQYPGGGPTIAPTPTKATPQTSVLSQDDRPPISIRRVLPSAATWYDLFEAALLCVPDSQLLLAIALFSYFILVNGLCDMSHYHLQIGINLALLACTNFVLSFALVRNYWKSPSAAFIRVVCACLVLGGLGVIFDARRRRGYTAESSPSKNDSLILLNAGCFLDDGHDDDLRKLTATNGTGRIVGGLNEAVLSSHDAVFWIVLVGATSAILIFHVFRFIHRKVSGRHGSDDHDDNGHTAPAPKLFLAWAFMLFVALLVLTCITVASTARNREWVRRSGWMADDTEEESVKSFGQIAALVAMVTVMIAMFDKIVRRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SSJ2</accession>
    <name>A0AAN6SSJ2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Mitochondrial outer membrane translocase complex, subunit Tom5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_34477</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the Tom5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854356">
        <property type="protein sequence ID" value="KAK4041524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SSJ2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005742">
        <property type="term" value="C:mitochondrial outer membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006626">
        <property type="term" value="P:protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019603">
        <property type="entry name" value="Tom5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28188">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28188:SF1">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10642">
        <property type="entry name" value="Tom5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4041524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="50" mass="5318" checksum="38C06087467F1EDB" modified="2024-10-02" version="1">MFGGFQPPQASPEELRAAEAEATFTIQRALAAAAALYLSPFVVDAVSKMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SSJ9</accession>
    <name>A0AAN6SSJ9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_15417</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854370">
        <property type="protein sequence ID" value="KAK4040760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SSJ9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4040760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="94" mass="10367" checksum="B31C167B8EA74206" modified="2024-10-02" version="1" fragment="single">MPVPPSPPPPGERRRYAPLTPSPLNPNTYLANINNKIRPQQEHPASTTTKANNKTQKPDPTTQNPSTLPQKYAALAHASPTQRLLRQKAAAAWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SSS9</accession>
    <name>A0AAN6SSS9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GST N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_35026</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854366">
        <property type="protein sequence ID" value="KAK4040970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SSS9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00299">
        <property type="entry name" value="GST_C_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03038">
        <property type="entry name" value="GST_N_etherase_LigE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054416">
        <property type="entry name" value="GST_UstS-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22041">
        <property type="entry name" value="GST_C_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="18"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Glutathione S-transferase UstS-like C-terminal" evidence="2">
        <location>
            <begin position="114"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4040970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="245" mass="27273" checksum="6DD65AC15A13EF8D" modified="2024-10-02" version="1">MSGQIVLFDIPSKQGTCWSLNPWKTRLLLNYKGLDYRTEWLEYPNIRPTLEPHLPNNGSSTPYTIPTILLPSGTYIMDSRAIATALEAAHPSPPLHLDSPALPRLESLLRRVMIALKPIYIVRVPKVILNEASVPFWNETRAAAQGVTSLEEYERANVDLGPRWEEAEPALREVTDLLGEAPPGKGPFFLGNVVSYADFVWAGFLIFMGRLGEDVLEEVLVRSGGGERHRALLEGLGPWVKRAGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SSU4</accession>
    <name>A0AAN6SSU4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TRP C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_15361</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854369">
        <property type="protein sequence ID" value="KAK4040821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SSU4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010308">
        <property type="entry name" value="TRP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040241">
        <property type="entry name" value="TRP_Flc/Pkd2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145:SF8">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_2G17475)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_7G01610)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06011">
        <property type="entry name" value="TRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042827178" description="TRP C-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="32"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="326"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="394"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="421"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="480"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="TRP C-terminal" evidence="4">
        <location>
            <begin position="396"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="547"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="596"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="712"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="559"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="600"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="636"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="656"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="670"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="712"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="748"/>
            <end position="770"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4040821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="770" mass="83179" checksum="FCE6C7AC37CC6BCF" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6STR8</accession>
    <name>A0AAN6STR8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">U2 small nuclear ribonucleoprotein A'</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_14562</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the U2 small nuclear ribonucleoprotein A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854352">
        <property type="protein sequence ID" value="KAK4041723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6STR8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000026">
        <property type="entry name" value="U2 small nuclear ribonucleoprotein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044640">
        <property type="entry name" value="RU2A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10552">
        <property type="entry name" value="U2 SMALL NUCLEAR RIBONUCLEOPROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10552:SF6">
        <property type="entry name" value="U2 SMALL NUCLEAR RIBONUCLEOPROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14580">
        <property type="entry name" value="LRR_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4041723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="247" mass="27385" checksum="7003B640DF51BD54" modified="2024-10-02" version="1">MRLTADLITNSLSYLNPLKERELDLRGHRIPAIENLGVAGPHDAIDLTDNDIQVLGNFPLSPRVRTLLLARNRIAAVQATLPAAVPNLRNLVLAGNSLGELADLDVLGRFARLTHLVLVDNPVVKKEHYRYWVLWRCPTVRFLDYQKVKDAERAKAKELFGSAEAPTELASQIMGVKSKTFDVGAANGPAGGQGSKLSRLKLTDKERKKLQEMIKKADSLEEIIRLEKALNEGRLPPGVMVEDPMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6STX4</accession>
    <name>A0AAN6STX4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Oxysterol-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_13434</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the OSBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854333">
        <property type="protein sequence ID" value="KAK4042964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6STX4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.120:FF:000016">
        <property type="entry name" value="Oxysterol binding protein (Orp8), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF212">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="135"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="415"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="140"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="170"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="415"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="440"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4042964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="472" mass="52105" checksum="8D202A05A4994A05" modified="2024-10-02" version="1">MWAFSSSTPAAAPPPDAPAAEEPQNDGSKLRTFIGILRKFIGVADLASVRFSLPSQLLEPTPNLEYWNYLDSPNAFVAIGTADEPVDRMLEVLRFWFTKDLKYAKGKPCKPYNSCLGEFFRCNWETEDDAPKIDTSTLWKGGSAPGSSASSTKSAKLAVPAGLGSGDSRAASTVSVSQSAKNPTKPVRVSYLTEQTSHHPPVSAFYISCPEKGIHAKGFDQITAKFTGTSIKVMPGEHNLGIFITVERRDHETYQLTHPAAHLGGILRGALSVSVGDMCYITCPETKLKAILRYYDDGWLGRTTNKVEGIIFRYDPENDNKRQIQDVPEEDILVRLGGPWKEKIVFTLGSKPLASHPPEHQITIIDIAPLAVAPKVLPPAEQQLPHESLQLWGEVTKAILAKQYSRATTVKQELEEAQREKARERERKGETYKPVFFEQATDKAGKPSLTEKGREVLNRAQKGEWGMEDIVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SUL6</accession>
    <name>A0AAN6SUL6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_13251</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Mitochondrion inner membrane</location>
            <topology evidence="1 8">Peripheral membrane protein</topology>
            <orientation evidence="1 8">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the small Tim family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854330">
        <property type="protein sequence ID" value="KAK4043177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SUL6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0811">Translocation</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Tim10-like" evidence="9">
        <location>
            <begin position="25"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4043177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="93" mass="10618" checksum="73661668887FD140" modified="2024-10-02" version="1">MASDLTIDQSDIEKLNDKDKTELRQFFANEEHRSRIQSQTHELTSICWKKCITPRSGGGALDKTEQSCLANCVDRFMDANLATMKHLASMRQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SVQ4</accession>
    <name>A0AAN6SVQ4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycosyl transferase family 25 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_31994</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854323">
        <property type="protein sequence ID" value="KAK4043896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SVQ4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06532">
        <property type="entry name" value="Glyco_transf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050757">
        <property type="entry name" value="Collagen_mod_GT25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002654">
        <property type="entry name" value="Glyco_trans_25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10730:SF53">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 25 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10730">
        <property type="entry name" value="PROCOLLAGEN-LYSINE,2-OXOGLUTARATE 5-DIOXYGENASE/GLYCOSYLTRANSFERASE 25 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01755">
        <property type="entry name" value="Glyco_transf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl transferase family 25" evidence="5">
        <location>
            <begin position="45"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="210"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4043896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="394" mass="43742" checksum="A92226512915B204" modified="2024-10-02" version="1">MVLRHRIVAAPLAAVVTLFLWLTPEWVTPASKPPRDILNSTLGFQHIFAINLPWRTDRRDALALAAALSELDITWVDGVAGIDVLEKVLPGDPSSRKGGFTSGNKGSWRAHMDVLQRIVYENVTSALILEDDADWDVRLKTQMQVFAQASRAFTQPSDGLSLAEQYRNHPDPELRLAQMPRRTPRARLTPYGDDWDVLWLGHCGTDFPHTTAPTKPPSLRVTIPNDMTVPRPKHLRPHPFALQDALSEEYPPHTRVVHASAGTTCTQAYAVSQQGARKLLWQFGLQTLTTGWDLMLRDWCDGLHTPTNADTAEGGAPNGKRRAPICVTMQPPLFSHHYGKGAASDIMAPGGGFVDKDKEMTPYVRVSVRLNMERLVHGQEGTEQWDDEGVHLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SVS4</accession>
    <name>A0AAN6SVS4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_42812</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854319">
        <property type="protein sequence ID" value="KAK4044377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SVS4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052998">
        <property type="entry name" value="Hetero-Diels-Alderase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42060:SF1">
        <property type="entry name" value="NHL REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42060">
        <property type="entry name" value="NHL REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042872866" evidence="1">
        <location>
            <begin position="25"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4044377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="328" mass="34041" checksum="96691CAFD73EE06F" modified="2024-10-02" version="1">MKYSRQSLRSHLLLLLSSPLPALALSTPTTIFTLPGPVAPASWFENLAVRPNGLILATRGDAPEIWQIDPATGQGALLVSVAGAFNLTGIAEVMPPHRHPKHRSCAAETYVFGSAHIPAPLQVEPASAKVWTLQFPTTTTTGIPSVSLLAAMPTAGFINGITAWSRGRVLLSDTEAEAVYLMDVATGSYSTPLTGLAGINGIKATTKPWLGYVYRADHASQTLSRIPVDDDAVATGPAEVLAAGQAIDDFTIVVDGDGAGKAYIGAMFENQVVEVGFGAAPSSGPGARRVVAENLSGTGTGLVTVVAFGRQAQDAGLFASIVRLDPSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SW54</accession>
    <name>A0AAN6SW54_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_31505</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854319">
        <property type="protein sequence ID" value="KAK4044450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SW54"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4044450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="147" mass="16827" checksum="174110BDA6AEC99A" modified="2024-10-02" version="1">MDIPISTEYPKLQVADPTRPSLANLPLEIVLEILDALFKPEQIIRTRRERPPTQGHAPGLSPLLVPLRAEDEIVGVMDVTTWPQFKMEMELSLRWPQFLVAEERRPLYLPGYLVDERRLNDPIAFGWSRFRPAGGPEEDFSLLRAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SWA7</accession>
    <name>A0AAN6SWA7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Acetylserotonin methytransferase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_42649</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854318">
        <property type="protein sequence ID" value="KAK4044466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SWA7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="562"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="331"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="569"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="583"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="603"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4044466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="661" mass="69921" checksum="C45C364A5B8AB8F8" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SWC4</accession>
    <name>A0AAN6SWC4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">uracil phosphoribosyltransferase</fullName>
            <ecNumber evidence="4">2.4.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">C8A01DRAFT_31175</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uracil: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UPRTase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.9" evidence="4"/>
    <dbReference type="EMBL" id="MU854317">
        <property type="protein sequence ID" value="KAK4044675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SWC4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004845">
        <property type="term" value="F:uracil phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000049">
        <property type="entry name" value="Putative uracil phosphoribosyltransferase urg2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050054">
        <property type="entry name" value="UPRTase/APRTase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001097">
        <property type="entry name" value="PRK00129.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32315">
        <property type="entry name" value="ADENINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32315:SF4">
        <property type="entry name" value="URACIL PHOSPHORIBOSYLTRANSFERASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14681">
        <property type="entry name" value="UPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="6 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="10">
        <location>
            <begin position="10"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK4044675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="226" mass="23741" checksum="EB3F8DDC8D5E7BB2" modified="2024-10-02" version="1">MSTLPPNVHVSQHPCLLAKLSQLRSQDTPSKDVKGLIHDISLIVACEALAKGLTSVPGPTDKTPLGFDFQTHQLLPATVSLVPILRSGLGMVEAIQTLLPNPVPVHHLGLYREPTTLHPVEYYNNLPNHAAGATGAASELAIILDPVIATGGTCAAAIQTLREWGTQRIIVLSVLGAAAGVKAAAAEWPAGVEIWLAGVDEELTDRGMLKPGLGDVGDRLFLTIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P3N1</accession>
    <name>A0AAN6P3N1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_42350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU855092">
        <property type="protein sequence ID" value="KAK4031159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P3N1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4031159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="278" mass="31224" checksum="979F21C56EBA44F9" modified="2024-10-02" version="1">MAALEPPRTGGFMARSGPVETVLRILQCCHSTRDLLALVSTCRHICNVWRGNVAAVLWPVWLREIPHFEDALHAARMTELVVQAERRGELPPTRITPDLLQRQQPTLSELRAAFGLYRLSRTIAACLYSQDLTYPDDRPGGDFGRGPPPEDPARMPEWTARVSHAVFRLLIVGAALAGAYKEPLFKALEHPDPEIRALPQRVPQVAAQNTWEHKLGHKEMAFLLQFAVCDLDATLEAQDAAFGSIADWLLESILSDTESRQAMADRFEQRYGRSTFYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P4X2</accession>
    <name>A0AAN6P4X2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ubiquitin-like protease family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_41817</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854715">
        <property type="protein sequence ID" value="KAK4031734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P4X2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4031734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="324" mass="37859" checksum="CA443078647D10BB" modified="2024-10-02" version="1" fragment="single">MPRKKDTWMSEEARPADRSENLTDPYGNEHYFDDDPDLSNAGDSDIINLKRHLYLQKADLSAYTHPGASSRNLFLLDRPIIDYPPEVIARRPDWIACPDLSSNRETVKFLFPGWKGPFNNIDFECHGSPFYNIAATLFDVEGHILGRYQLESFHILNLLRLALCTYEKEVFIHPTCMTDNIDAPHEVLHGRILRSKPQSLRWWVFLCYRFDTHWALAIHDQAAEMTFYLDSGKESDRQSHEDFLRTRIRPIVVDTMAYQEERTWSSRIVPATAQAGSWECGLWVVEYTRIFFQEFWGRLLAGCPEIKLNMTRCYWGDTLQVARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P5D2</accession>
    <name>A0AAN6P5D2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_41494</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the putative lipase ROG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854654">
        <property type="protein sequence ID" value="KAK4032074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P5D2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007751">
        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052374">
        <property type="entry name" value="SERAC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182:SF3">
        <property type="entry name" value="DUF676 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF676" evidence="3">
        <location>
            <begin position="39"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="356"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="356"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="368"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4032074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="378" mass="42025" checksum="86EF1FF200C53DB7" modified="2024-10-02" version="1">MTTNSTTVTNYDKNNQGLFVLDPPHSKWERQYGAPDLDVVAVHGLNGDCFLTWTSGSSKAEKATWLNDHLLYKLPRTRVMTFGYNASIVGNTSVAGIRDNARKLLTLLRDKREDDGTRRRPIVFIGHSLGGIIIKQALRTARNEPRFVDIADCTKGIVFFGTPHRGTDAANWGQLIASIKTASFGARPRFDWFKMLRPNSVDLMNVSEDFRPLATQYALVSFIEDNPYGKWGVIVEKHSAVLELPHEEQFIISGDHSTMCKFSNTAPDHARFDTVWRAIKHAAQGPDTSTTVEIRATYNKNNAPRQMAGNYDPAIVKRGAPGSGPALVTARLEGPGYGNGQGMLPWQDVRGGGKERVVAGKGQRWEETVEEWPNEGWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P5L0</accession>
    <name>A0AAN6P5L0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Geranylgeranyl pyrophosphate synthase A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_41529</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854659">
        <property type="protein sequence ID" value="KAK4032035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P5L0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046165">
        <property type="term" value="P:alcohol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001:SF72">
        <property type="entry name" value="THIJ_PFPI FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_3G01210)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4032035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="318" mass="34909" checksum="79AA8B03ADCFB58F" modified="2024-10-02" version="1">MASEIKLSTGDLLGSEHLEAPSSYVKSLPSKGVRDTLADALNLWADLHEDSVTQIKEVVGDLHTASLMLDDIEDGSELRRGHPAAHSVFSTPQTINAASFAIVEAVRKAHELSSVIPGADDITFEQLRDLHIGQSHDLHWTRHASCPTEEEYLDMVSKKTGGLFRLLSRLMCSHLDTETASAIDNLVQQIGIYFQVRDDFSNIDSAEYTAQKGLYEDLDEGKLSFPLIHHLTTASPSSALQVREILEQRREAGAGGLSEAHKELVLRQLRESGSVDYTRKTLVGLEGLIDGLVAGLERATGRENWVLRFCLQKLSVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P6T8</accession>
    <name>A0AAN6P6T8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNA recognition motif-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_50480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854573">
        <property type="protein sequence ID" value="KAK4032824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P6T8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4032824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="442" mass="47258" checksum="99C440EA185F88FD" modified="2024-10-02" version="1">MAARPGEEHVATLYGDIHYFYGPPTHNPPHHRFDNGSYVYLFEDANQGRARLEVANHPGTDDQDAFDGYLDRVHVRYSYKHTCLVTLTVGEVEGNDEWHLPTYDPHNQNKYHYKLHSLDIYFWMPQDAVQFVNGIRRVLPPAQCEVLDEPGPPPRHEAEMSSVVQKLEQAAISGSNSLQATPAGLQPSAAGLPSFPGPPMSAVAGAGDATSPPSQQFSPIAYNPAAPPAPEEVRYREKTPPPDDGVANPLHQTLAYDAATPFSPGLVPSGLGPLSPGIPPPNLQHPPGAPTFPGPPQHSVTSPGFAPQGFGSLGGQAAAGMSHQPPVHPGISRAATMPVHGVGSPLASPGLASPYGVGTFPPHVQYTPGVTHTPTPPAAGVGAPPQAGQAQVPHDYSVHQQFYIPQDQYKPKQESKGRFEENAGRLERGVTGMFKKIEKKFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P743</accession>
    <name>A0AAN6P743_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sas10 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_41939</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854747">
        <property type="protein sequence ID" value="KAK4031613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P743"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053134">
        <property type="entry name" value="RNA-dir_DNA_polymerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018972">
        <property type="entry name" value="Sas10_C_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559:SF444">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559">
        <property type="entry name" value="TRANSPOSON TY3-I GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09368">
        <property type="entry name" value="Sas10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sas10 C-terminal" evidence="3">
        <location>
            <begin position="112"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4031613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="174" mass="19973" checksum="38F3754039381AA1" modified="2024-10-02" version="1">MLEAIRQHPYLAEFADVFSKESNELPPSRECDHEVEVEPGHQLRTSPLYSLTLDQLETMRKYLKDCLERGFIVPSSAPFASPVLLNAGTVKNRYPLPLIDETLRQLGKADRERGLTPHRKKEVRNPRVKKRMKYEERQKKLRSVKAVYKGGEGPGRYQGELSCKKTGLVKIVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P7L7</accession>
    <name>A0AAN6P7L7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_40349</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854546">
        <property type="protein sequence ID" value="KAK4033189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P7L7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4033189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="290" mass="32508" checksum="566179BD74E3DBA0" modified="2024-10-02" version="1">MVFEVGGRLLKTHSDTGYPRAFNQAFTAFPRDVGFNNSLSAPQPNFVEGLEIREYQPFPVDEQVSGAVLFRDDPFSVTLPHIAGEWKGRGKDMDEAKMQSAHAEVATFTADGTNINFFAHCAATSEAGVLEYHQYPITSTNLTNSFEDFKKGRKQLRNLQDDARDLSYALRDRLKGHWATHRGPMPSTDQTDGCLRDVPEEAELDPVEQEGDAALPLSAMVAQEELADIGHDVVVDEFIYVPSPPGSSKQDRQQQSSQRRRTAPPKPVRRPRTLRKQAQQRNASLRREEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P7V3</accession>
    <name>A0AAN6P7V3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_20877</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854666">
        <property type="protein sequence ID" value="KAK4031988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P7V3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052374">
        <property type="entry name" value="SERAC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182:SF2">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="70"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="72"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4031988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="162" mass="18106" checksum="CEC74CF914874826" modified="2024-10-02" version="1" fragment="single">RIGFTELSGSHSARDGPYRVNIIFVHGLRGHPPHTWEDSRVRGRVDRANKDAGTARSRRRDILPALFKSKPSSSASISTATSTVDDETSEESPNKLFWPDEYLTQDIPEARVWTYGYNADTIGGLLQTNSKNSVFGRIQTPHTQRRVVGIRSPSPTLLQHSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P837</accession>
    <name>A0AAN6P837_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Reactive mitochondrial oxygen species modulator 1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_49920</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MGR2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854526">
        <property type="protein sequence ID" value="KAK4033498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P837"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018450">
        <property type="entry name" value="Romo1/Mgr2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28525">
        <property type="entry name" value="REACTIVE OXYGEN SPECIES MODULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28525:SF1">
        <property type="entry name" value="REACTIVE OXYGEN SPECIES MODULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10247">
        <property type="entry name" value="Romo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01378">
        <property type="entry name" value="Romo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="23"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4033498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="114" mass="12260" checksum="0956924BE8D2395C" modified="2024-10-02" version="1">MPPPPSHPGGVGPSNFDKFKMGAMMGGSVGIIIGFIFGTVNIFRYGAGPNGIMRTLGQYMLGSGATFGFFMSIGSVIRSDASPIVQEAYLRAQRRPIIMASQAFRPYQPARRDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P999</accession>
    <name>A0AAN6P999_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_19029</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854494">
        <property type="protein sequence ID" value="KAK4034126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P999"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4034126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="90" mass="9550" checksum="1FA32A126A4718B6" modified="2024-10-02" version="1">MADQLQSNIIEDNPIGNGLDAFRASFHMVCTDRTISRVPDAAAWLMASGTKSSARMRSAATSASGSGPSFFSRSVRASVCAIGPTSMMFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P9H6</accession>
    <name>A0AAN6P9H6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Benzoate 4-monooxygenase bphA</fullName>
            <ecNumber evidence="12">1.14.14.92</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Benzoate-para-hydroxylase A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Cytochrome P450 monooxygenase cyp53A1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">C8A01DRAFT_39282</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>benzoate + reduced [NADPH--hemoprotein reductase] + O2 = 4-hydroxybenzoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18033"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16150"/>
            <dbReference type="ChEBI" id="CHEBI:17879"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="1.14.14.92"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.92" evidence="12"/>
    <dbReference type="EMBL" id="MU854488">
        <property type="protein sequence ID" value="KAK4034224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P9H6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018664">
        <property type="term" value="F:benzoate 4-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11061">
        <property type="entry name" value="CYP67-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000053">
        <property type="entry name" value="Cytochrome P450 benzoate 4-monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF29">
        <property type="entry name" value="BENZOATE-PARA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 16 17" id="KW-0349">Heme</keyword>
    <keyword evidence="7 16 17" id="KW-0408">Iron</keyword>
    <keyword evidence="9 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 16 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 17" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="16">
        <location>
            <position position="459"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00066552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00072826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00081895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00082391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAK4034224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="510" mass="57202" checksum="F5AC590C55537079" modified="2024-10-02" version="1">MAIINLLLSPWAPVALLVAAVVYYVYPYLVTYRQLKNIPAPFPAQFTNWWLLLVCRRGDRYDTVDKLHKKLGPVVRIQPNHVSLCDDEAINLVYGHGNGFLKADFYDAFVSIQRGLFNTRDRHEHTRKRKIVSHTFSVKSVAQFEPYIHSNLELFVRQLDNLIARSNNADGAAYLDCLNWFNYLAFDVIGDLAFGAPFGMLSSGADIAEVRASPDSPPIYAPAIEILNRRGEVSAALGILPDLKPYAKYFPDPFFTQGLQAVENLAGIAIARVKARLENPPPAQRKDLLQRLIDGRDDKGEPLGRQELTAEALTQLIAGSDTTSNSSCALLYHAVRTPGVIQKLQAELDAALPADLDVPTFELVRDLPYLSAVVNETLRFHSTSGIGLPRQVPPDGQGIHYNGHYFPPGTVLSVPTYSIHHSKEIWGADADDFKPERWESLTARQKNAFIPFSYGPRACVGRNVAEMEMKLIVATWARRYQVFLRQDYMDTKEGFLRKPLGLEIGLKRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P9L5</accession>
    <name>A0AAN6P9L5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_40724</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>alpha-D-galactosyl-(1-&gt;3)-1D-myo-inositol + sucrose = raffinose + myo-inositol</text>
            <dbReference type="Rhea" id="RHEA:20161"/>
            <dbReference type="ChEBI" id="CHEBI:16634"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:17505"/>
            <dbReference type="ChEBI" id="CHEBI:17992"/>
            <dbReference type="EC" id="2.4.1.82"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolases 36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854573">
        <property type="protein sequence ID" value="KAK4032813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P9L5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047274">
        <property type="term" value="F:galactinol-sucrose galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008811">
        <property type="entry name" value="Glycosyl_hydrolases_36"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31268">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31268:SF32">
        <property type="entry name" value="GALACTINOL--SUCROSE GALACTOSYLTRANSFERASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05691">
        <property type="entry name" value="Raffinose_syn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4032813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="876" mass="96466" checksum="B436B9B96B12F8FA" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P9S6</accession>
    <name>A0AAN6P9S6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutamine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">C8A01DRAFT_49244</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>tRNA(Gln) + L-glutamine + ATP = L-glutaminyl-tRNA(Gln) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20121"/>
            <dbReference type="Rhea" id="RHEA-COMP:9662"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.18" evidence="2"/>
    <dbReference type="EMBL" id="MU854483">
        <property type="protein sequence ID" value="KAK4034353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P9S6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004819">
        <property type="term" value="F:glutamine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006425">
        <property type="term" value="P:glutaminyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.240.10:FF:000007">
        <property type="entry name" value="Glutamine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.240.10:FF:000015">
        <property type="entry name" value="Glutaminyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000183">
        <property type="entry name" value="Glutaminyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="entry name" value="Ribosomal Protein L25, Chain P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004514">
        <property type="entry name" value="Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050132">
        <property type="entry name" value="Gln/Glu-tRNA_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020059">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_codon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_bL25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_bL25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049437">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00440">
        <property type="entry name" value="glnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097:SF4">
        <property type="entry name" value="GLUTAMINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097">
        <property type="entry name" value="GLUTAMINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03950">
        <property type="entry name" value="tRNA-synt_1c_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20974">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="Ribosomal protein L25-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic" evidence="11">
        <location>
            <begin position="110"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding" evidence="12">
        <location>
            <begin position="423"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA synthetases class I (E and Q) anti-codon binding" evidence="13">
        <location>
            <begin position="533"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="51"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF20974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK4034353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="652" mass="73922" checksum="9074A0E0C41DFD5F" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P9S8</accession>
    <name>A0AAN6P9S8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_40670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854567">
        <property type="protein sequence ID" value="KAK4032888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P9S8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="90"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="28"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4032888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="156" mass="17256" checksum="0C1A5FE291FBC8E0" modified="2024-10-02" version="1">MSRNRSLKTKKQRHGRKPKRPAPASAKPVPPVSPAPAPGADPAKPAPDSPPAPKHSPKPAPSVSIVRRATHQDHRLKAKVRLLGKKVAHLEKCESHLARALKELDAARAQIDKLNTAMDYLLSKPPHDGRYFDKNYGLSPKWTRSKWECPMKPDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P9W0</accession>
    <name>A0AAN6P9W0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Centromere/kinetochore protein zw10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_20064</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854563">
        <property type="protein sequence ID" value="KAK4032933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P9W0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990423">
        <property type="term" value="C:RZZ complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046362">
        <property type="entry name" value="Zw10/DSL1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055148">
        <property type="entry name" value="ZW10_C_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12205">
        <property type="entry name" value="CENTROMERE/KINETOCHORE PROTEIN ZW10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12205:SF0">
        <property type="entry name" value="CENTROMERE_KINETOCHORE PROTEIN ZW10 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22766">
        <property type="entry name" value="ZW10_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ZW10 C-terminal helical" evidence="2">
        <location>
            <begin position="690"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="416"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="448"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="482"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4032933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="849" mass="93364" checksum="44BCAFBD9BC3CFAD" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PAA1</accession>
    <name>A0AAN6PAA1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_18578</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854471">
        <property type="protein sequence ID" value="KAK4034639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PAA1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40640">
        <property type="entry name" value="ANCHORED GLYCOPROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40640:SF1">
        <property type="entry name" value="ANCHORED GLYCOPROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042823596" evidence="1">
        <location>
            <begin position="19"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4034639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="180" mass="18886" checksum="042E1409B4111C51" modified="2024-10-02" version="1">MLFKTTLMLVAGVMSAGAHILGAPVAVTPQAAPTVVNLFLGAKRESNYSFAASVIAADAVATTYRIHCESGALNMPGFPTTTCDQNDPPWTVTEGPSTMVGILTTAIESVTAVLDERCIIEGRTAAYCNYTFSGNSAGTTTYTAYTTIITGDLFYEYPVVVTEGAEKLLVPVATPCVQRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PAH4</accession>
    <name>A0AAN6PAH4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_20218</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854578">
        <property type="protein sequence ID" value="KAK4032751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PAH4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050745">
        <property type="entry name" value="Multifunctional_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189:SF50">
        <property type="entry name" value="ANKYRIN REPEAT AND SOCS BOX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189">
        <property type="entry name" value="MYOTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="4">
        <location>
            <begin position="48"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="521"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="554"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="587"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="620"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="658"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="691"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="724"/>
            <end position="749"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4032751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="788" mass="87055" checksum="4B585B82017A04C1" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PAS0</accession>
    <name>A0AAN6PAS0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">C8A01DRAFT_19220</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="MU854504">
        <property type="protein sequence ID" value="KAK4033907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PAS0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007234">
        <property type="term" value="P:osmosensory signaling via phosphorelay pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16922">
        <property type="entry name" value="HATPase_EvgS-ArcB-TorS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000004">
        <property type="entry name" value="Ethylene receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000289">
        <property type="entry name" value="Osmosensing histidine protein kinase SLN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050956">
        <property type="entry name" value="2C_system_His_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43719">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43719:SF34">
        <property type="entry name" value="TWO-COMPONENT SYSTEM PROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="12 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 14" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="397"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="17">
        <location>
            <begin position="566"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="18">
        <location>
            <begin position="983"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="433"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="734"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="893"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1111"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="439"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="453"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="743"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="893"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="14">
        <location>
            <position position="1038"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAK4033907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1160" mass="126136" checksum="F75DE7818513ACF8" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PAU2</accession>
    <name>A0AAN6PAU2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">C8A01DRAFT_48781</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854460">
        <property type="protein sequence ID" value="KAK4034951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PAU2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF7">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="269"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="307"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="339"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="382"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="420"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="451"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="10"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="512"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK4034951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="551" mass="60270" checksum="E1A430EEFEB9E2CA" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PBC2</accession>
    <name>A0AAN6PBC2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_48495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854449">
        <property type="protein sequence ID" value="KAK4035289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PBC2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="535"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="535"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4035289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="565" mass="60058" checksum="221DCF389229B0BC" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PBL6</accession>
    <name>A0AAN6PBL6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Blue light-inducible protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_49661</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854508">
        <property type="protein sequence ID" value="KAK4033818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PBL6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052917">
        <property type="entry name" value="Stress-Dev_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038725">
        <property type="entry name" value="YdaG_split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34818">
        <property type="entry name" value="PROTEIN BLI-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34818:SF1">
        <property type="entry name" value="PROTEIN BLI-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16242">
        <property type="entry name" value="Pyrid_ox_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="General stress protein FMN-binding split barrel" evidence="2">
        <location>
            <begin position="31"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4033818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="205" mass="22061" checksum="43A86F0982C04539" modified="2024-10-02" version="1">MAQQQPDPSAKHADPYKEANLDSGVPLEQKIQDLSGFMGHCKFGMMTTRDAASGNLVSRCMALAAQETGGIDLLFHTNTESGKTVDLASDSHINIGFLNSSGEWASVSGKANVVTDRSLVQKHYSQHLRAWLGDLGDGVHDGGENDPRIGIIRVKMTTAHYSISSKTMIGQMAEIAQGVVTGKPAAVNKLREISEAEVTQWRSSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PBS5</accession>
    <name>A0AAN6PBS5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Delta 8-(E)-sphingolipid desaturase</fullName>
            <ecNumber evidence="5">1.14.19.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">C8A01DRAFT_40073</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.18" evidence="5"/>
    <dbReference type="EMBL" id="MU854528">
        <property type="protein sequence ID" value="KAK4033471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PBS5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016717">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03506">
        <property type="entry name" value="Delta6-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353:SF30">
        <property type="entry name" value="DELTA 8-(E)-SPHINGOLIPID DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353">
        <property type="entry name" value="FATTY ACID DESATURASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015921">
        <property type="entry name" value="FA_sphinglp_des"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="13" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="8 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="213"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="343"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="376"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="405"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="17">
        <location>
            <begin position="23"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAK4033471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="545" mass="61295" checksum="30D0124E9FDBF48A" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PC60</accession>
    <name>A0AAN6PC60_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fip1 motif-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_38764</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FIP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854466">
        <property type="protein sequence ID" value="KAK4034775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PC60"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007854">
        <property type="entry name" value="Fip1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051187">
        <property type="entry name" value="Pre-mRNA_3'-end_processing_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13484">
        <property type="entry name" value="FIP1-LIKE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13484:SF0">
        <property type="entry name" value="PRE-MRNA 3'-END-PROCESSING FACTOR FIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05182">
        <property type="entry name" value="Fip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pre-mRNA polyadenylation factor Fip1" evidence="6">
        <location>
            <begin position="150"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="299"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="12"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="88"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="299"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4034775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="345" mass="35576" checksum="9BDAFC98B99B2DEF" modified="2024-10-02" version="1">MDIDDEDDFYAPEEAPAPAQPAPAEEAPAPKKDANEELESGEEEDEGGAMDEDEDSDIDIITERKDGSNPAPPPQSRYSEIKNIPQRTTADIPTATTTTSAHKPAPPSAADPTTTTTTTTTMPPSTSKLDINAIPTHKPTNKPLTQVNIDTDLPAEQDKPWRKPGTDLSDYFNYGFDEFTWALYAQKQEALRAEYDPDAIAQSNKKMMEEMTSMMMMGGMGMAPPGAGGPGGPAQAGGAVVPGGGPGGGAGAVGQMAGMEGVTPEVRAMMQQMMANGMDPSQMDMGAMAAMYGGGGAGAGGPGQGGQGQGFGSGFGGGQGQGYGYEQQMGGGGGGRGGRGRGRRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PD00</accession>
    <name>A0AAN6PD00_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RlpA-like double-psi beta-barrel-protein domain-containing protein-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_37725</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854432">
        <property type="protein sequence ID" value="KAK4038337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PD00"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22191">
        <property type="entry name" value="DPBB_RlpA_EXP_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051477">
        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009009">
        <property type="entry name" value="RlpA-like_DPBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF28">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03330">
        <property type="entry name" value="DPBB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042847628" evidence="2">
        <location>
            <begin position="23"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="RlpA-like protein double-psi beta-barrel" evidence="3">
        <location>
            <begin position="45"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4038337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="144" mass="14572" checksum="66071EDC2DE93A4B" modified="2024-10-02" version="1">MFASTITSVLAITATLLGAVAATPISATGAIEAAGADKRAALTSGKFTYYNAGLGACGQTHSDADLVVAMSHVDFDPSSPNGSPNNNPLCGRRIRAAIGGKTVDVTVVDRCEACNSGDLDLSPTAFGVLSALSVGVIQGTWEWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PD16</accession>
    <name>A0AAN6PD16_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Acyl carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">C8A01DRAFT_37419</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Carrier of the growing fatty acid chain in fatty acid biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acyl carrier protein (ACP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854423">
        <property type="protein sequence ID" value="KAK4038651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PD16"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099128">
        <property type="term" value="C:mitochondrial [2Fe-2S] assembly complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000035">
        <property type="term" value="F:acyl binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000036">
        <property type="term" value="F:acyl carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000003">
        <property type="entry name" value="Acyl carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01217">
        <property type="entry name" value="Acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003231">
        <property type="entry name" value="ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00517">
        <property type="entry name" value="acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002148">
        <property type="entry name" value="PRK00982.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863">
        <property type="entry name" value="ACYL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863:SF28">
        <property type="entry name" value="ACYL CARRIER PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="13 14" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6 14" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 14" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Carrier" evidence="15">
        <location>
            <begin position="62"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK4038651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="141" mass="15251" checksum="9F934F4E231C4F3B" modified="2024-10-02" version="1">MLRTAILRSAVLATRAAVRPIPAAAARRLAVAPAPRIASFVPNVAAWQAVRCYASGSSLDKTEVYERIKQLLSGFDKVNDPSNITESAHFANDLGLDSLDTVEVVMAIEEEFSIEIPDKDADTIHSVDKAVEYILSQPDAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PD66</accession>
    <name>A0AAN6PD66_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_49357</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854490">
        <property type="protein sequence ID" value="KAK4034191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PD66"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097237">
        <property type="term" value="P:cellular response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050097">
        <property type="entry name" value="Ferredoxin-NADP_redctase_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48105">
        <property type="entry name" value="THIOREDOXIN REDUCTASE 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00469">
        <property type="entry name" value="PNDRDTASEII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="4">
        <location>
            <begin position="5"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4034191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="294" mass="30685" checksum="0C4FA119F0041381" modified="2024-10-02" version="1">MPLVDALIIGAGPAGLSAALALARQLHTAVVFDSSLFRNARSAHMHTIPTWDHKDPAAFRGATRKEILERYSTISFEDCEVAKIEKAILLASGVTDLPLDIKGYDECWGRSIYHCLFCHGYEDAGKPSAGILALGENSVPAVATALARSAKQITSKAVIYTSNNPAVQTAIADLLGQNNTAITTDDREIASLALGAEGSGITITFADGSSVPEAFLAHKPPTKLNGPFAEQLGVELAPGGDIKVTPPFGATSVKGVYAAGDCATPMKNVMQAMHMGTFAGVGIAHDLQAEGPKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PD73</accession>
    <name>A0AAN6PD73_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_39337</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854490">
        <property type="protein sequence ID" value="KAK4034206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PD73"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07830">
        <property type="entry name" value="STKc_MAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000233">
        <property type="entry name" value="Meiosis induction protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000314">
        <property type="entry name" value="Serine threonine-protein kinase mak"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="25"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="365"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="429"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="557"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="373"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="383"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="447"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="626"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4034206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="775" mass="85139" checksum="EE769D0B7F170409" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PDI1</accession>
    <name>A0AAN6PDI1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_39166</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854483">
        <property type="protein sequence ID" value="KAK4034341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PDI1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4034341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="336" mass="36613" checksum="CA747584686EB3D8" modified="2024-10-02" version="1">MPVLSALHGASSTVLSNLFVKLPTPTAIPGLPQQIIIVTGSNTGLGLETSRHLLRLGLGKLIMAVRNLDKGHEAKKELLASTGRDEASVEVWHLDMDRYNSVTQFAALASQLPRLDGVLANAGIMTTQFSVSEGHEKTLTVNVISTLLLCLLLMPKMRESRKQTGWPCRFVIPNSALHYLAPLGELDDGPDHPIIARLDDQDKADMGGRYPLSKLLVLYAVRELADRAKASGKGLFILNSPNPSYCVSNLARETQGSVGVKTAEKLIARTTEEGSRTLYHGLFAGEESNGQYLTNCHVQDPACHVTNQWGQRVQKKFFEELLATLEQIQPGISANV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PDN9</accession>
    <name>A0AAN6PDN9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquinone biosynthesis O-methyltransferase, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">3-demethylubiquinol 3-O-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.64</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">3-demethylubiquinone 3-O-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.-</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Polyprenyldihydroxybenzoate methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.114</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">COQ3</name>
        <name evidence="7" type="ORF">C8A01DRAFT_18777</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">O-methyltransferase required for two non-consecutive steps during ubiquinone biosynthesis. Catalyzes the 2 O-methylation of 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoic acid into 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoic acid. Also catalyzes the last step of ubiquinone biosynthesis by mediating methylation of 3-demethylubiquinone into ubiquinone. Also able to mediate the methylation of 3-demethylubiquinol into ubiquinol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoate + S-adenosyl-L-methionine = a 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoate + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44452"/>
            <dbReference type="Rhea" id="RHEA-COMP:10930"/>
            <dbReference type="Rhea" id="RHEA-COMP:10931"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64694"/>
            <dbReference type="ChEBI" id="CHEBI:84443"/>
            <dbReference type="EC" id="2.1.1.114"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3-demethylubiquinol + S-adenosyl-L-methionine = a ubiquinol + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44380"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="Rhea" id="RHEA-COMP:10914"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:84422"/>
            <dbReference type="EC" id="2.1.1.64"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3-demethylubiquinone + S-adenosyl-L-methionine = a ubiquinone + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:81215"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:19654"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:231825"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion inner membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.64" evidence="5"/>
    <dbReference type="EC" id="2.1.1.-" evidence="5"/>
    <dbReference type="EC" id="2.1.1.114" evidence="5"/>
    <dbReference type="EMBL" id="MU854480">
        <property type="protein sequence ID" value="KAK4034431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PDN9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061542">
        <property type="term" value="F:3-demethylubiquinol 3-O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010420">
        <property type="term" value="F:polyprenyldihydroxybenzoate methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00472">
        <property type="entry name" value="UbiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010233">
        <property type="entry name" value="UbiG_MeTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01983">
        <property type="entry name" value="UbiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464:SF19">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS O-METHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 5 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 5" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="11"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4034431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="304" mass="32937" checksum="BBBD19E46FC9516F" modified="2024-10-02" version="1">MRPSLRHVPRALRTARPASRAAAAAAAPWLQHPQPQPPSRHLSTTSPTLHTPSSSSVNATEISHFSALASSWWDPHGPSRPLHLMNPLRHDFIQACLASSPTTSPPYSNLRYLDVGCGGGIFAESAARLPTTASVTAIDPSPTILAVARAHAKRDPSLGGKKLTYLSETIESLPLPAEPADRFDVVSVFEVVEHVDYPAAFLDRVGEFVKPGGWLVLSTIARTWTSWVTTNLVAEDILGVVPKGTHDWYKYINEGELRGYFGGKGGVWGPPRVMGVVFVPGLGWREVRGSEKVGNYFLGVQRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PDZ0</accession>
    <name>A0AAN6PDZ0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">t-SNARE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_47358</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the syntaxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854409">
        <property type="protein sequence ID" value="KAK4039153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PDZ0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15840">
        <property type="entry name" value="SNARE_Qa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000059">
        <property type="entry name" value="Related to syntaxin 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.70:FF:000018">
        <property type="entry name" value="SNARE domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006012">
        <property type="entry name" value="Syntaxin/epimorphin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006011">
        <property type="entry name" value="Syntaxin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF38">
        <property type="entry name" value="LD27581P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14523">
        <property type="entry name" value="Syntaxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00503">
        <property type="entry name" value="SynN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00914">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="5">
        <location>
            <begin position="174"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4039153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="268" mass="30200" checksum="30E00BEC3A6D149D" modified="2024-10-02" version="1">MSFDQLSSLEAGRRRGTPGYADDPDFQRLSQDLMNKLFKLNGNNQRLSGEVGHLGTRRDTPRVRERVHELIEESRDTFKDVGEGVKAMQGWEDVTPTQRYMQQKLSREFQSSLSEFQSLQRQALEKQKASVSAARAAVDHEGEPTAGGPASPQLLQQQQELTRLAPQDEVDFQEALIIEREEEIRNIEQGVGDLNVLFQQVAQIVTEQGEVLDTIERNVEVVRDDTHGADRELRSAARYQKNARSKACCLLVILTVILTIILLAVFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PE87</accession>
    <name>A0AAN6PE87_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">tRNA (guanine(10)-N(2))-methyltransferase</fullName>
            <ecNumber evidence="9">2.1.1.214</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">C8A01DRAFT_18172</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM11 methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.214" evidence="9"/>
    <dbReference type="EMBL" id="MU854454">
        <property type="protein sequence ID" value="KAK4035123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PE87"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043527">
        <property type="term" value="C:tRNA methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160102">
        <property type="term" value="F:tRNA (guanine(10)-N2)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000672">
        <property type="entry name" value="RNA methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000241">
        <property type="entry name" value="RlmKL-like_Mtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016691">
        <property type="entry name" value="TRMT11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059073">
        <property type="entry name" value="TRMT11_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13370">
        <property type="entry name" value="RNA METHYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13370:SF3">
        <property type="entry name" value="TRNA (GUANINE(10)-N2)-METHYLTRANSFERASE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25904">
        <property type="entry name" value="Tmrp11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01170">
        <property type="entry name" value="UPF0020"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017259">
        <property type="entry name" value="tRNA_mtfrase_TRM11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00507">
        <property type="entry name" value="N12N6MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51627">
        <property type="entry name" value="SAM_MT_TRM11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 10" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3 10" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="tRNA (guanine(10)-N(2))-methyltransferase TRMT11 N-terminal" evidence="12">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal RNA large subunit methyltransferase K/L-like methyltransferase" evidence="11">
        <location>
            <begin position="181"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00066937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF25904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK4035123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="458" mass="51230" checksum="5AAC2D9BA665290E" modified="2024-10-02" version="1">MDYLIRFSQSHETFRLPEIQALALIEGIDLKVVSYSLESPFCIVHLPSETAARRLIQRSILAMSIHELWGSGPDLAAVHASVHASTAHLWAKYLTCSFKFTLDSYQGSRTADAKIAIINSFAYLGFAGPIQMRRPDEEFILFEDWQLNSTPLGIPDPKFYYFGRYLGAGARDLPKKLDLKKRRYISTTSMDAELALVTANIALAAPGKVMYDPFVGTGSFPIACAQFGAVTFGSDIDGRSIRGDEKKRTLRGNFEQYGLVAGLGGMFTADLTNSPIRRAELRYDGDGVQGRLFDGIVCDPPYGVREGLRVLGVRDPEKCPWVIPKGKEMYKDPDFIPPRKPYSFLAMLDGILQFSAQTLVDNGRLSFWMPTANDENQEIPVPTHPYLDVVAVCTQTFNKWSRRLITYRRIPDAQVDQEAMKAREEMKPVGKTADELNPFRKAYFNGFEPVDGTSDEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PEE2</accession>
    <name>A0AAN6PEE2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LCCL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_47087</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854400">
        <property type="protein sequence ID" value="KAK4039444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PEE2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.20">
        <property type="entry name" value="LCCL-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051957">
        <property type="entry name" value="CRISP-LCCL_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004043">
        <property type="entry name" value="LCCL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036609">
        <property type="entry name" value="LCCL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31331:SF8">
        <property type="entry name" value="LCCL DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G02970)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31331">
        <property type="entry name" value="LCCL DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G08630)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03815">
        <property type="entry name" value="LCCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00603">
        <property type="entry name" value="LCCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69848">
        <property type="entry name" value="LCCL domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50820">
        <property type="entry name" value="LCCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="125"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="301"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="392"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="428"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="461"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="LCCL" evidence="3">
        <location>
            <begin position="226"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4039444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="893" mass="97709" checksum="856FFC4CDB0D6558" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PEG4</accession>
    <name>A0AAN6PEG4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_16597</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854401">
        <property type="protein sequence ID" value="KAK4039401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PEG4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="80"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4039401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="472" mass="49896" checksum="FA3382D2739FCBF7" modified="2024-10-02" version="1">MTDMGVQLEPISQSLEQYGPWRFGDARFEDDHRAELEAALLQTAAIPGLGDRLLEISKGSRAGCHSPARSEVTLSVSKVRSTPRSSPGPASRASTPVTTTKAVPSLFPTTLDPSLAFTQVVPSGKAVVTFPLAAPSPQPRPCLKRRRPDTDVDGPGTFSISCKKRRLLRHLITSRLSQPFSLPATHILNREAVAAGDKKIVKLAAIMSARRLNNAVTAPSQAPSPPQQPSPSTWLRRAAVLNSLRSRVYATAAERANIPVPDLAAKTAVFQQSHGSTTAFVGGRYLITSPNQPAPAPHGPPPSQPTPGAHPHHHPAHAHAHAHAHLPACTTRLRIPSPKLRPLRSPELRVTRPLVPLEDIEPLLSSSSDDYYYNNALLSSPDDGVAFPTSELESRYGYDDDDDNGEGGEDGEGGGVYADFSVIFGGGGGGGSEEDGEGGGGGREGGLGGSDCFEDYMDDLDGIPWGGGAMLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PEQ1</accession>
    <name>A0AAN6PEQ1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heterokaryon incompatibility protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_17975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854447">
        <property type="protein sequence ID" value="KAK4035348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PEQ1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF12">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="62"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4035348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="309" mass="35239" checksum="CD16F1AD03E44F1F" modified="2024-10-02" version="1" fragment="single">MVEGARIDPEKVNYRRVQDWLRRCDDKHDGTCCRLPRSCPVQISCVDCYTREIVPIAPDADYLALSYVWGDKKTLPEAESVERLPGDDKVPRVVRDAMVVVRELGKRYLWVDQYCIDQKNEDNKRRQILHMDQVYEGAYATIVAAAGPDAEFGLPGVAGRCRNEQLFAETPTITLLQVPWTLGASLSLNAWMTRGWTYQEAVLSRRLLVFTEQAVYFVCAAMKRCEGVLIGTDDANLGQGERLITLHSKALSVAQGHFDSLQTDGYTLLRHLLSHIQHYSPRRLTFQTDRLSAFRGILSRWPFYSYFGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PER3</accession>
    <name>A0AAN6PER3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal export protein NMD3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">C8A01DRAFT_48710</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NMD3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854457">
        <property type="protein sequence ID" value="KAK4035046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PER3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039768">
        <property type="entry name" value="Nmd3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007064">
        <property type="entry name" value="Nmd3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048899">
        <property type="entry name" value="NMD_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048898">
        <property type="entry name" value="OB_NMD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12746:SF2">
        <property type="entry name" value="60S RIBOSOMAL EXPORT PROTEIN NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12746">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04981">
        <property type="entry name" value="NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21193">
        <property type="entry name" value="NMD_SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21192">
        <property type="entry name" value="OB_NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="43"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Nmd3 N-terminal" evidence="11">
        <location>
            <begin position="360"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="domain" description="60S ribosomal export protein NMD3 SH3" evidence="13">
        <location>
            <begin position="593"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="domain" description="60S ribosomal export protein NMD3 OB-fold" evidence="12">
        <location>
            <begin position="657"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="784"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="20"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="158"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF21192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF21193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK4035046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="831" mass="91917" checksum="E49F9C9F949FB50A" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PER8</accession>
    <name>A0AAN6PER8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_16383</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854395">
        <property type="protein sequence ID" value="KAK4039639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PER8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4039639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="109" mass="12332" checksum="4D973C991B85CF3D" modified="2024-10-02" version="1">MTEHSQQRPDIEPRRASASVADTWTQTEEEQAPEQHIASLARTKSLDRNKQLAPRRSAQDDQVIRRRGEAVAQHHDDRGGAPAVRLDMDLDIDIKMQAKIKGEIELSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PEW2</accession>
    <name>A0AAN6PEW2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidoligase enzyme-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_17858</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854443">
        <property type="protein sequence ID" value="KAK4035438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PEW2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022025">
        <property type="entry name" value="Amidoligase_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36847">
        <property type="entry name" value="AMIDOLIGASE ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36847:SF1">
        <property type="entry name" value="AMIDOLIGASE ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12224">
        <property type="entry name" value="Amidoligase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="386"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="518"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4035438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="527" mass="59673" checksum="A419BDDBFE3795DA" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PF63</accession>
    <name>A0AAN6PF63_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Beta-lactamase/transpeptidase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_47484</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-A beta-lactamase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854414">
        <property type="protein sequence ID" value="KAK4038968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PF63"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050789">
        <property type="entry name" value="Diverse_Enzym_Activities"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43283:SF17">
        <property type="entry name" value="(LOVD), PUTATIVE (AFU_ORTHOLOGUE AFUA_5G00920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43283">
        <property type="entry name" value="BETA-LACTAMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="3">
        <location>
            <begin position="17"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4038968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="401" mass="44609" checksum="51D89BC942D83658" modified="2024-10-02" version="1">MTPEFEARLKKAIDERVLPCAVVLARDKSGKIDYTFSHGPTTLKKDAPPISPTTMFTMASMSKLITSICLLKLVEGNILEIDENVTMYLETLAKQPILTGFDATGDPTYKKRTTPVTLRHLLTHTAGTGYILMEERLQRWCRATGRAVPIPLKHSPVSGGMSVDSRFGYPLLFEPGQGWVYGSGVDWAGRLIEKLTGAFFDDFLYENVLKPVGITKGAITFHPGRFHEPLFDLMAGMGKRNPDTGKVEFMETEYDEDNEGFGGEGLYGGMGEYMKVLYSILMDDGKILQPETTKLLFQPLLHENEKDALNKNLQATDWAVGHIPKGIEYDWSAGGLLSVGGEDMGKRKKGFLQWGGAWNMAWFIDREAGVCGVFGTQVFQVNDPEAKEFMKAFEEAVYSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PFN8</accession>
    <name>A0AAN6PFN8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MMS19 nucleotide excision repair protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_48600</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MET18/MMS19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854453">
        <property type="protein sequence ID" value="KAK4035162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PFN8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097361">
        <property type="term" value="C:cytosolic [4Fe-4S] assembly targeting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039920">
        <property type="entry name" value="MMS19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024687">
        <property type="entry name" value="MMS19_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029240">
        <property type="entry name" value="MMS19_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12891">
        <property type="entry name" value="DNA REPAIR/TRANSCRIPTION PROTEIN MET18/MMS19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12891:SF0">
        <property type="entry name" value="MMS19 NUCLEOTIDE EXCISION REPAIR PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12460">
        <property type="entry name" value="MMS19_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14500">
        <property type="entry name" value="MMS19_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="MMS19 N-terminal" evidence="6">
        <location>
            <begin position="77"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="MMS19 C-terminal" evidence="5">
        <location>
            <begin position="744"/>
            <end position="1110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4035162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1156" mass="127600" checksum="A808330EDD20EFD1" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PFT9</accession>
    <name>A0AAN6PFT9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ammonium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_38314</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854451">
        <property type="protein sequence ID" value="KAK4035222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PFT9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3430.10:FF:000003">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="entry name" value="Ammonium transporter AmtB like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018047">
        <property type="entry name" value="Ammonium_transpt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00836">
        <property type="entry name" value="amt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029:SF10">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111352">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01219">
        <property type="entry name" value="AMMONIUM_TRANSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="230"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="349"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="389"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium transporter AmtB-like" evidence="9">
        <location>
            <begin position="37"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4035222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="476" mass="50672" checksum="E80C792C3ED909D1" modified="2024-10-02" version="1">MSAGPLTEYGGVTGVADSGGDSVTEDLNIYYSAGDFAWIITSSALVLLMVPGVGFFYSGLARRKSALALIWLSLISIAIVGFQWFFWGYSLTFSHTGSAYIGDLSNFGLMKVLGQPSVGSTKLPDILFCLYQGMFAAITPALAIGAAADRGRMLPCVVFIFIWATIVYDPIAYWTWNANGWSFKMGGLDFAGGTPVHISSGAAALAYSLMLGKRTGYTKVNGLPYRPHNVTHVVLGTVFLWVGWFGFNGGSALAANTRAVMACVVTHIAACVGGFTWCLLDYRLERKWSTVGFCSGVISGLVAITPAAGYVPPWSAVVFGVVGGVVCNFATKLKFVLGVDDALDIFAEHGVGGIVGNLLTGLFAADYIAHLDGFTKIPGGWVNQNYVQLGYQLADSVAGFSYSFVMTCVILFLMNFVPGLSLRVSAEEEEIGLDDGELGEFAYDYVEITRHIDGAMTGMSGSPSHSIKGHIPEKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PG91</accession>
    <name>A0AAN6PG91_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">1-alkyl-2-acetylglycerophosphocholine esterase</fullName>
            <ecNumber evidence="1">3.1.1.47</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_46487</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.47" evidence="1"/>
    <dbReference type="EMBL" id="MU854383">
        <property type="protein sequence ID" value="KAK4040172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PG91"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003847">
        <property type="term" value="F:1-alkyl-2-acetylglycerophosphocholine esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10272:SF14">
        <property type="entry name" value="PAF ACETYLHYDROLASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10272">
        <property type="entry name" value="PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042889142" description="1-alkyl-2-acetylglycerophosphocholine esterase" evidence="5">
        <location>
            <begin position="19"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="6">
        <location>
            <begin position="126"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4040172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="382" mass="41229" checksum="F4A7246C1DDCC4CC" modified="2024-10-02" version="1">MQSMLSVLFLLLANTTAGYLVPNPSGKYNVTLTTGPLVDYSRNDPYAATPTPRALMLSVFQPARCASTVPALAMPNKTADYQGEFLQQTFNISADLTPLFLEARLPVCADHAHKRCSPLDDSPILLFSPGYSIPRLYYNVLASAIASEGFTVITIDHPHDANILVYPDSHAVYNNVSIQDSPTWDAYTRAADASFVIDQLRNATAMAELLPYRGARPFPTDRVAMLGHSIGGASAIIAASQDPRIRAAINWDGTIFGSPPPPGLGLSEPVRLMSQPVLFLSHQDFLDPSWLSTWPLLRGPKMVAYVANTTHYTFSDIPSLFEAAGQSTAPFADLLGTIAPASVVCILTAYTTAWVQAAFAGEKGGLELGEFPEVETLMKGNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PGG2</accession>
    <name>A0AAN6PGG2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_46915</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854395">
        <property type="protein sequence ID" value="KAK4039658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PGG2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF20">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="27"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4039658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="485" mass="53740" checksum="A5E0ACC4A1ABEEC6" modified="2024-10-02" version="1">MTSSPSHAAISGPGAPSRPKRAQVSKACQRCRRLQKRCSESRPCPRCARVGLEEECLRGEGHAQQPIDGNWSYPQLPASLSPEAAHATSPLAVLPQRRRSLPPASVVGYCFRRFMAKLYPTIPILSPEYAELLAVEADSPQGAEAQCLVTAVCAVVLIQVEEPGRRLFEADGILHSTREFGELLFEDAMAAHNHLSLRFNPCLERVLATFFLYAGHASLFHHSQGFYFLREAATLWLVLRIDEGDGLRRRLADRLFWVILVSERSHGIRYRRPVTLQVVPSGPDLDADAESDTNLSGLRRLVALFRPLDTVFFALLNQEDTVFVSRLVSPLDAIQAAIGSALEPQHMGELCETQVANLKVTQLWLLVVLWQLRLRLGLLVEEPGMPCHLTFHYPVEVGEELAGVIRAISLESIRVHGVGINEKIFDVACAMVDVLSRVPATDKSGTGLESIRYFRELIHELPGGVSTYDVLLDKHMTNTLPGLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PGP9</accession>
    <name>A0AAN6PGP9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Borealin N terminal-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">C8A01DRAFT_36228</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the borealin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854392">
        <property type="protein sequence ID" value="KAK4039778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PGP9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032133">
        <property type="term" value="C:chromosome passenger complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051233">
        <property type="term" value="C:spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018851">
        <property type="entry name" value="Borealin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018867">
        <property type="entry name" value="Cell_div_borealin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16040">
        <property type="entry name" value="AUSTRALIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16040:SF7">
        <property type="entry name" value="AUSTRALIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10444">
        <property type="entry name" value="Nbl1_Borealin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Borealin N-terminal" evidence="11">
        <location>
            <begin position="56"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="113"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="239"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="159"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="241"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="338"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="352"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF10444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK4039778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="401" mass="42070" checksum="A7335E0CED2202C8" modified="2024-10-02" version="1">MQPPSSRKRKSDQLDMSNDNQYAVDMASQKIPTKGGSPHPQESPSKRQRVGITLAQKQALIDNLQLEITERARKLRANYNIHAQSLRTRIEIRVNRIPLSLRKLTMGELLEKYSKEPQQKPSANTGVARGPPVPAKDVPSRPPTRGTATSAHPSKRRSHEISGGDKENEVQTPQKKKMRAYPAATDLARNPAHVLSPTTSNSRFAPRTVATPGRSGIARPAVTPGRAVVATNILNKMVEGARSTTRPTTATTSSSTSTAARKTAATSTATTTAASTTSAAAARRKRGATVTAAVNHHPAPPSSSSSRPATRTGARRASGTSESIEGSTATVIRKPRPMTAPPGAQPKPPPTAAQLTTATGGAKRTTVMGAIKKGVTGGGTTKKAAAAGSGTGTGRVLRKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PGY5</accession>
    <name>A0AAN6PGY5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">C8A01DRAFT_17165</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="MU854419">
        <property type="protein sequence ID" value="KAK4038789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PGY5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05684">
        <property type="entry name" value="S1_DHX8_helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000061">
        <property type="entry name" value="ATP-dependent RNA helicase DHX8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000001">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000101">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000191">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049621">
        <property type="entry name" value="S1_DHX8_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF85">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="12">
        <location>
            <begin position="178"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="480"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="661"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="127"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="273"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="400"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="277"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK4038789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1142" mass="127078" checksum="81F9F2A7639C1D49" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PHH2</accession>
    <name>A0AAN6PHH2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Regulator of chromosome condensation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_47406</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854411">
        <property type="protein sequence ID" value="KAK4039074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PHH2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00625">
        <property type="entry name" value="RCC1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="171"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="RCC1-like" evidence="5">
        <location>
            <begin position="173"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="228"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="307"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="360"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="417"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="474"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="539"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="242"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="30"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="126"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="141"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="255"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4039074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="595" mass="62934" checksum="67B2DB6846AECBEC" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PHI0</accession>
    <name>A0AAN6PHI0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein transport protein sec1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_47364</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854410">
        <property type="protein sequence ID" value="KAK4039089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PHI0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005715">
        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="620"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="661"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="673"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="707"/>
            <end position="721"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4039089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="721" mass="80865" checksum="E67F799F14F2996F" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PHT3</accession>
    <name>A0AAN6PHT3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA ligase</fullName>
            <ecNumber evidence="12">6.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">C8A01DRAFT_35074</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate.</text>
            <dbReference type="EC" id="6.5.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 13">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="12"/>
    <dbReference type="EMBL" id="MU854367">
        <property type="protein sequence ID" value="KAK4040902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PHT3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
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</entry>
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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        <submittedName>
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        </lineage>
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
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                <person name="Brannstrom I.O."/>
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                <person name="Lipzen A."/>
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                <person name="Ament-Velasquez S.L."/>
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                <person name="Powell A.J."/>
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                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAK4041574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <location>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="357"/>
            <end position="414"/>
        </location>
    </feature>
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        <location>
            <begin position="131"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4041574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="510" mass="54667" checksum="3384D5321B76F8F0" modified="2024-10-02" version="1">MASLGSGQAGASANKIAKGRGKMVKPIFKKLSHSEKNSLDLDRGWDEQQIEQLEAGGWDGGFGYAGQARDVSFGFAGAAGPGAGDSTTGLGSGGSAIRAANLKYQHGRSGSQTSAGSGPPRAAFVHPFAQTPRTSTPPLSYANSLASFDNGRDCSPTITEHEDDEGFDSGAATSSYLHMHTHHPHAHANSQSSQHPPAGSISQSNLRRPSLNSTRTLSFPETPASNPPSLRINTGGRSISGTTATSSSRLAHGSLPSPSQSDLHIDLHNLSVSLSGTLDSPTGSLGAGSGIASPSQQQSQLSPLRTSLDMAGFPRLRSHSEIDTATRIENIRAARRKFEEREREKEEKYDREMIRKRERRDNKEASRIERGEAPSRPAMHRKKTATGLSTVSEPGMKSTKPNQSTPHLGLLPAPAKSSGIVLGIGRRRHTDSPTSANMTKGEKQMGFAARRYESVSLVPQTPPSFGITVDDVRFEHPQPRRGSGAKRKTQGYWQGFLLWLRTKLLRMSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PIH1</accession>
    <name>A0AAN6PIH1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_14926</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854360">
        <property type="protein sequence ID" value="KAK4041277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PIH1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4041277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="361" mass="38885" checksum="37855AB2C0490E40" modified="2024-10-02" version="1">MPSPNPAGNANGNGIAATALPSPLLRKATILSFLPALPLCITHGALSNDVVPALGLIPLFFSAGVSLFLLVRSRRDGGKGKGMSERGGRADLEGLRRVATAAGVEQEEEEGQGIGPDDDDDDDEDEERDGGSVLTHRISVFVVDVVLAAGLMVVLVFTWIRTGQEGERRPELAMLAAYGTVPLLVNFLIHLYLAVCEFVAGLAIPALVEYSAWHVVSPDCPHCGNRLRPESLPPIPWHETVSRPNVSLPQITAPSISRPSLPAFKLPNLSGLKGAREWKVPSWMRGRNQDASLFVDDDQNERDRYRDDPDGPFDEPSGTTTVVATGSAVPAPVEVVVGKKDRRENIVPSAGWPEDEDEVRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PJY0</accession>
    <name>A0AAN6PJY0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Beta-lactamase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_33800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854345">
        <property type="protein sequence ID" value="KAK4042167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PJY0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025638">
        <property type="entry name" value="DUF4336"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33835:SF1">
        <property type="entry name" value="METALLO-BETA-LACTAMASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33835">
        <property type="entry name" value="YALI0C07656P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14234">
        <property type="entry name" value="DUF4336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4042167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="279" mass="31264" checksum="4A024FCC6BBAC0F8" modified="2024-10-02" version="1">MSSKLIPPNPDEVMVIRDVTPNVVTFSVPFLRFGRFPIGGRGTLVRLTTGALAVFSPVALTEATKAKVASLGGDVRYLVATDIEHHIFLSEWAAAYPDAKLVGPEGLPEKRQKAPQDDPKIGREPFAVVVTKENKKTVKIGDDFDADFDMEYLHMHPNKELVFLYRPDRVVVEADLMFNLPAEEQYSRVPEAQRPKVGLLGKLFNSFQTTQGEALGMKRFQWHVASRSDRKGFNESVRRIAGWEFDTIVPCHGETIVGNGKEVFERVFAWHLEGKGARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PK79</accession>
    <name>A0AAN6PK79_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_34332</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854354">
        <property type="protein sequence ID" value="KAK4041608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PK79"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="365"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="181"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="416"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="461"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4041608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="494" mass="51705" checksum="24B7DE5691A8DBA9" modified="2024-10-02" version="1">MSAPTAAHGGTAPLAALTAVFTPPCPTSWLLTTTRSFSQYPPFPTTGPASCDPPSWRTNIARAGFHYYSPAICPQGFVVGPGCGITKTRTDEGFPAIAPGETAVYCVPSGLTCTTDITDFRGGVWGFARDATTPGALVTVGPAIQIRWVEADLTKLETHPLTPGLKLARTSSEKTRDPGMGSTTTTGPASGTTGAPENRPAPEGRDTESATLITDTKTGDVESFSHIFETADPTNSLAPANTAAGNSSGGLGSLDRTTSIVVIVVVTVVAGIALWTAAFLLVRRYKNKAAKRKASYPTTDDDETSLEQGRRHARADSGVPKSIVSPASELDAGPPAIGSTPNPAELEGDVFGQLPAKTWVHQRLWPKGPSLQPPQSSPRSMATTRSTRRTVRESFGEKVNDPAAALGRLRIPNPLSMGRPSPSSASPSTRSFWRMTRSPRSPAAAARLSAQLQLPKPSPRSGMSGNASRASTPGRGNPGWQGGQASKQQRDETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PKC2</accession>
    <name>A0AAN6PKC2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Mitochondrial PGP phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_45221</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854353">
        <property type="protein sequence ID" value="KAK4041683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PKC2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008962">
        <property type="term" value="F:phosphatidylglycerophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000165">
        <property type="entry name" value="HAD superfamily phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027706">
        <property type="entry name" value="PGP_Pase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010021">
        <property type="entry name" value="PGPP1/Gep4"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01668">
        <property type="entry name" value="YqeG_hyp_ppase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288">
        <property type="entry name" value="4-NITROPHENYLPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288:SF25">
        <property type="entry name" value="PHOSPHATIDYLGLYCEROPHOSPHATASE GEP4, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09419">
        <property type="entry name" value="PGP_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4041683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="215" mass="23690" checksum="A6B4108840C9635E" modified="2024-10-02" version="1">MNLNLSASLNIFKLLAKPSLCLPHATVATFDDLPVPLNKAFSRNDKQADIRAVVLDKDDCFAIPDHSKVHEPYKKRRFEALRAAYPGRRLLIVSNTAGATSYDVDGRLASEVERSTGVNVLAHAVKKPGCGDEILSYFRQHPETGVTSPHQIAIVGDRLATDMMLANMMGSWGVWVKEGVVPLQQKSIFSKLERKLGPYLLSRGYSAPEPSSPFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PKS0</accession>
    <name>A0AAN6PKS0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_13595</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854335">
        <property type="protein sequence ID" value="KAK4042798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PKS0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4042798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="252" mass="26537" checksum="DE7F191D715FD753" modified="2024-10-02" version="1" fragment="single">MNSQPECCPFTPAASSQGVYPRPHDAKDAVVSRCPTDYYSVSGSCCPSAYTPWTAALGGATPCYSTISAATTPSPPPAGDAVAPRATRPTVTVTATVFAMRYAVTDDGAALSPGAIAGIIVGGVVLAGLVLGLYMVCCRRRRANNPFDAVEAGLGDNHEPAPGSSEVPNSRDSMSLQGLFRRLTRADEKWPFGLPQPFPESELKVSPTKYAGLSIDGECPMKFMPALPPEPAYKRADDCEAKLTRPRRLSPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PKW1</accession>
    <name>A0AAN6PKW1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_15726</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854378">
        <property type="protein sequence ID" value="KAK4040360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PKW1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00882">
        <property type="entry name" value="Ras_like_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="2">
        <location>
            <begin position="38"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="267"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4040360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="448" mass="50318" checksum="3DA1DB6816F4E83C" modified="2024-10-02" version="1">MILVLEMRFAAEELADQAQRFAAFTGVTKPQPTDKFFLVMGMTGSGKSTFVARCTGQKVVVGHGLHSCTNSVGVFDFPWNGRRIYLVDTLGFNDTTRPDLEILDILATYLSTSYANGIRIHGFIMLHPISDNRMTGSSLRNIEMMKAMCGLASYHNLAIVTTMWPSTPDHAEKLMLERRYAELLADGRFFGDLVARGAHLFRHNETGRRNAFEEATSARRIVDRLVRQSDIHAPDVLRLQKEIVDEGKTLGETTAGIAVAGELYKARRAHELELRGLQAEMNSQLARVDAAHAAQIRELEADVMMKLKKAEDAKRALRRRMDEMHRDEERAWKQKIRELDEMFSQQLAEKQQELLDMEESLLEIRQDMARRAPNQREPTPRQRELMALQIAEHEEIVTSARAEVSNTQHAYQKFQGQTGNILNGTANGVAAGLTSGIVAGEPPSSLET</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PL59</accession>
    <name>A0AAN6PL59_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Nitrogen permease regulator 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4 5">Required for meiotic nuclear division protein 11</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_44839</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 5">Mediates inactivation of the TORC1 complex in response to amino acid starvation. Required for meiotic nuclear division.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Vacuole membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the NPR3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854346">
        <property type="protein sequence ID" value="KAK4042060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PL59"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990130">
        <property type="term" value="C:GATOR1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038202">
        <property type="term" value="P:TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056603">
        <property type="entry name" value="HTH_NPRL3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005365">
        <property type="entry name" value="Npr3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13153">
        <property type="entry name" value="CGTHBA PROTEIN -14 GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13153:SF5">
        <property type="entry name" value="GATOR COMPLEX PROTEIN NPRL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24064">
        <property type="entry name" value="HTH_NPRL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03666">
        <property type="entry name" value="NPR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0469">Meiosis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="GATOR1 complex protein NPRL3 C-terminal HTH" evidence="7">
        <location>
            <begin position="849"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="149"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="607"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="765"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="150"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="164"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="182"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="608"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="626"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="671"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="784"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="800"/>
            <end position="823"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU368069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF24064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4042060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="900" mass="98619" checksum="ADFA1572FA4C01C9" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PM30</accession>
    <name>A0AAN6PM30_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycoside hydrolase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_13160</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854329">
        <property type="protein sequence ID" value="KAK4043287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PM30"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033934">
        <property type="term" value="F:glucan 1,4-alpha-maltotriohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004574">
        <property type="term" value="F:oligo-1,6-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004575">
        <property type="term" value="F:sucrose alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000025">
        <property type="term" value="P:maltose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005987">
        <property type="term" value="P:sucrose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11333">
        <property type="entry name" value="AmyAc_SI_OligoGlu_DGase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000087">
        <property type="entry name" value="Oligo-1,6-glucosidase IMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.400.10:FF:000003">
        <property type="entry name" value="Probable alpha-glucosidase (Maltase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="entry name" value="Oligo-1,6-glucosidase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF222">
        <property type="entry name" value="MALTASE MALT (AFU_ORTHOLOGUE AFUA_8G07070)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0462">Maltose metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="3">
        <location>
            <begin position="17"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00026248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4043287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="575" mass="66508" checksum="0D652FD06732BF0E" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PMA4</accession>
    <name>A0AAN6PMA4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Apurinic-apyrimidinic endonuclease 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">C8A01DRAFT_12788</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AP endonuclease 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854325">
        <property type="protein sequence ID" value="KAK4043644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PMA4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00019">
        <property type="entry name" value="AP2Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.150:FF:000001">
        <property type="entry name" value="Probable endonuclease 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00152">
        <property type="entry name" value="Nfo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001719">
        <property type="entry name" value="AP_endonuc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018246">
        <property type="entry name" value="AP_endonuc_F2_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00587">
        <property type="entry name" value="nfo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002199">
        <property type="entry name" value="PRK01060.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21445:SF0">
        <property type="entry name" value="APURINIC-APYRIMIDINIC ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21445">
        <property type="entry name" value="ENDONUCLEASE IV ENDODEOXYRIBONUCLEASE IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00518">
        <property type="entry name" value="AP2Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="Xylose isomerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00730">
        <property type="entry name" value="AP_NUCLEASE_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00731">
        <property type="entry name" value="AP_NUCLEASE_F2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51432">
        <property type="entry name" value="AP_NUCLEASE_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylose isomerase-like TIM barrel" evidence="10">
        <location>
            <begin position="145"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="425"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="425"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="459"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="474"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK4043644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="483" mass="51963" checksum="78741D832AB6B079" modified="2024-10-02" version="1">MVRQSTRKAAQAKPAQAKPAAVESRTRVKEEVVSVAAVKANGTEKTLTAVAESKVDAAKKTVSKRKSAPAEPELDGKDIENASPAEDKKQVQEPKKPAAKKRKTTKKEAEDTMPLAARTAVASLKRAMYIGAHVSGAGGVQNSIQNAAHIGANAFALFLKSQRKWASPPLADEAKSQFHALLKQHNYDATKHILPHGSYLVNLAQADAAKAAQAYDGFLDDLQRCEALGITLYNFHPGSTGGATTSSACARIAAQLNKAHAATSSVVTLLENMCGSGNVIGSRFEELRDIIALVDDKSRVGVCIDTCHAFAAGYDLRTPEAFASTMAEFDAVVGLKYLRAFHLNDSKAPFGSHRDLHANIGTGFLGLRAFHNIMNHEPLQGLPMVLETPIDEKGPDGKTVENKQVWADEIKLLESLIGMDVESDGFKEKEEELHAKGASERQKVQEQVDKKAEKDAKKGTKGKGKGKRKKKDEESCDSCGESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PMT7</accession>
    <name>A0AAN6PMT7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_14313</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854347">
        <property type="protein sequence ID" value="KAK4042014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PMT7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="1">
        <location>
            <begin position="13"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4042014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="394" mass="42777" checksum="16E30701567C195F" modified="2024-10-02" version="1">MNPLQSTLGISTHDVPSRVLHIIASELHVPVDDLKDDDIEFSELGVDALVAPPIIGKIAQATALQLPEDIFETFGTIAPFKKHIATLAQKTQHLKAEPGPALSVLIRNSTAKNTKGSQNLFLLPDGSGAAMAYARIPALPNVRIYAMNSPFLHNADNYTCTIEQLASLWAEAIAEIQPRGPYMLGGWSAGGYYAYEVMRHLQRKGEVVDRLVLIDSPCRTVFEALPFEVVLYLASNGLMGEPGRNANNNKAAPQWLVDHFKATLRAVDAYRPEGIASGGLAWPSTPGVFIIWASEPLLEEGRAAAAGLDPNVKVTRLLLQSRSDFGPNGWDTLFPPGASVRVAVVSCNHFNIVHPPNASHPHVEKLGRLLRDVVHPEGEAAWVNEWHRVGVSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PMU3</accession>
    <name>A0AAN6PMU3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Altered inheritance of mitochondria protein 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">AIM11</name>
        <name evidence="7" type="ORF">C8A01DRAFT_32045</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the AIM11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854324">
        <property type="protein sequence ID" value="KAK4043727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PMU3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038814">
        <property type="entry name" value="AIM11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39136">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39136:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042982313" description="Altered inheritance of mitochondria protein 11" evidence="6">
        <location>
            <begin position="20"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="12"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="222"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="44"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="58"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="226"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="241"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4043727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="253" mass="26809" checksum="842AFBE8FBEF5256" modified="2024-10-02" version="1">MGVLSLLLGSLTGVNPADSKTPPPPAAPTISAPAVAASPPPLSRPTTSTPAPRTQTPPLTPHQTPPPPAPPTDYYTHYISQRSFRQLGLFFAGTGFFYLSVMITRRAVARHKLAARLKFYEANHQFAGWGRSVQQETADSMLPKKDPLVAVEALNLATLNTLAFAIAAAGGLSWGLDISTLEDLRRYARRSIVLAGAEGAPDEVAEREVAEWVAKTFGIEERKGSAGDGGVGNGEGVEGAEGEKGVLEKEKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PN36</accession>
    <name>A0AAN6PN36_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_31891</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854322">
        <property type="protein sequence ID" value="KAK4044021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053210">
        <property type="entry name" value="ANKRD12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056485">
        <property type="entry name" value="ARM_KRIT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056015">
        <property type="entry name" value="DUF7593"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24149:SF14">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24149">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24521">
        <property type="entry name" value="Ank_KRIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24513">
        <property type="entry name" value="DUF7593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="395"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="428"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="KRIT1 ARM-repeats" evidence="4">
        <location>
            <begin position="535"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7593" evidence="3">
        <location>
            <begin position="1221"/>
            <end position="1380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="486"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="677"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1523"/>
            <end position="1558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="208"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="287"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="486"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="677"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="766"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
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            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="831"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="844"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="897"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="952"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1017"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1523"/>
            <end position="1536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4044021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1558" mass="175433" checksum="D9AD4407DDBF2CDD" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PN93</accession>
    <name>A0AAN6PN93_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="12">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Tyrosyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">C8A01DRAFT_33754</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>tRNA(Tyr) + L-tyrosine + ATP = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="12"/>
    <dbReference type="EMBL" id="MU854344">
        <property type="protein sequence ID" value="KAK4042254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PN93"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006437">
        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00805">
        <property type="entry name" value="TyrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.240.10:FF:000001">
        <property type="entry name" value="Tyrosine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000227">
        <property type="entry name" value="Tyrosine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002307">
        <property type="entry name" value="Tyr-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024088">
        <property type="entry name" value="Tyr-tRNA-ligase_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032005">
        <property type="entry name" value="TyrRSs_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00234">
        <property type="entry name" value="tyrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11766:SF0">
        <property type="entry name" value="TYROSINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11766">
        <property type="entry name" value="TYROSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16714">
        <property type="entry name" value="TyrRSs_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01040">
        <property type="entry name" value="TRNASYNTHTYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 12 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tyrosyl-tRNA synthetase C-terminal" evidence="14">
        <location>
            <begin position="434"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="573"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="594"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF16714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK4042254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="631" mass="70828" checksum="062093F48A54D770" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PNN5</accession>
    <name>A0AAN6PNN5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_31428</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854319">
        <property type="protein sequence ID" value="KAK4044373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PNN5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="58"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="324"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="434"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="500"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="333"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="388"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="434"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="457"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="505"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="520"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4044373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="537" mass="59143" checksum="D48EA59FEDFD7D76" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PNU8</accession>
    <name>A0AAN6PNU8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">sphingolipid C(9)-methyltransferase</fullName>
            <ecNumber evidence="14">2.1.1.317</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">C8A01DRAFT_32606</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CFA/CMAS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.317" evidence="14"/>
    <dbReference type="EMBL" id="MU854329">
        <property type="protein sequence ID" value="KAK4043288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PNU8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052290">
        <property type="entry name" value="Sphingo_C9-MT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45197:SF1">
        <property type="entry name" value="SPHINGOLIPID C9-METHYLTRANSFERASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45197">
        <property type="entry name" value="SYNTHASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G04190)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02353">
        <property type="entry name" value="CMAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 16" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="10" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00039020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK4043288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="524" mass="59302" checksum="B08722F8E0929B34" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PP98</accession>
    <name>A0AAN6PP98_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_31465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854319">
        <property type="protein sequence ID" value="KAK4044412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PP98"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="359"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="418"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4044412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="449" mass="43989" checksum="C0D2432FC073D3D7" modified="2024-10-02" version="1">MSANDINFPAALALAAALPGDDDAALAALAANDVALDVWTAGQAQQGSLLGDPAALPQPAKFAAAVFPPPAMGPQDFALAGADVTGLIAGGDQVFFGYAPLGFPNALPFPPAPLPAAVPPLAPGAQALDNGDDEDDDYPEAYALSPSPPAAPSVPFAPALGFFPPAAPAAAYDAAAAAGFFPAVPVPFPAAPQPQEQQQPDPPLAPGGHLVLPPDETPPGPPRGHLVGLLYVRGTTHAGHAAYVVGDGQEQWVQHRLQPCQMRAGQARQPTTPPALQLALDMLGVPAPGFPVFGGDVWGAWDAGAGVGLPAGHMMQQPGPFPPVWEGDVGGGGGGGGGLSAGQPGLFPPAGGFGGAGVSAGAAGSSAAPAPVGSPVPCSFGRSGASSRKDRRRAREQAKRAAAKGLSPRKADWMLPPYGGGCQGSGGPGGPRGPGGPGMGGGMGGGICG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PPJ3</accession>
    <name>A0AAN6PPJ3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">UDP-N-acetylglucosamine transferase subunit ALG13</fullName>
            <ecNumber evidence="2 7">2.4.1.141</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 7">Asparagine-linked glycosylation protein 13</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ALG13</name>
        <name evidence="10" type="ORF">C8A01DRAFT_13791</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 7">Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>an N-acetyl-alpha-D-glucosaminyl-diphospho-di-trans,poly-cis-dolichol + UDP-N-acetyl-alpha-D-glucosamine = an N,N'-diacetylchitobiosyl-diphospho-di-trans,poly-cis-dolichol + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23380"/>
            <dbReference type="Rhea" id="RHEA-COMP:19507"/>
            <dbReference type="Rhea" id="RHEA-COMP:19510"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57269"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58427"/>
            <dbReference type="EC" id="2.4.1.141"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1 7">Heterodimer with ALG14 to form a functional enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the glycosyltransferase 28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.141" evidence="2 7"/>
    <dbReference type="EMBL" id="MU854338">
        <property type="protein sequence ID" value="KAK4042616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PPJ3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043541">
        <property type="term" value="C:UDP-N-acetylglucosamine transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004577">
        <property type="term" value="F:N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007235">
        <property type="entry name" value="Glyco_trans_28_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052474">
        <property type="entry name" value="UDP-GlcNAc_transferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47043">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE TRANSFERASE SUBUNIT ALG13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47043:SF1">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE TRANSFERASE SUBUNIT ALG13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04101">
        <property type="entry name" value="Glyco_tran_28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl transferase family 28 C-terminal" evidence="9">
        <location>
            <begin position="59"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4042616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="283" mass="29830" checksum="487B4E5757D34572" modified="2024-10-02" version="1">MVNGVNGVGAGGDGGSSSGSDTVTAAQVRELKRQRLDFFNHGFEAHQPAAQPDLSGRHCFVTVGATAGFRSLLDEVSTAGFLESLAGHGFASLEVQCGPDHSAIWERLARLDEEERRGVAVSCFAYTGDMHAHIINCRGLAGVRPAGCVIAHGGTGTVGEVLGVGAPLIVVANPTLMDNHQLELAEDLEAQNLVVHGQIGSLTDALGRIAERITQGTLDNLPPYSPPSFPVSAADRVTFFDWMVLTCYPDELAVQMLQQPVVNGDVPAVAVDDQEDNGMLVFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PPU2</accession>
    <name>A0AAN6PPU2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">C8A01DRAFT_13376</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat ELP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854332">
        <property type="protein sequence ID" value="KAK4043049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PPU2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000400">
        <property type="entry name" value="Elongator acetyltransferase complex subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037289">
        <property type="entry name" value="Elp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44111">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44111:SF1">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="7 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="52"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="127"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="209"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="400"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="623"/>
            <end position="655"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK4043049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="824" mass="88921" checksum="1C54AC9B0E6A0664" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PQ69</accession>
    <name>A0AAN6PQ69_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">C8A01DRAFT_12435</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="MU854321">
        <property type="protein sequence ID" value="KAK4044190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PQ69"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21691">
        <property type="entry name" value="GH2-like_DHX8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05684">
        <property type="entry name" value="S1_DHX8_helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000061">
        <property type="entry name" value="ATP-dependent RNA helicase DHX8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000001">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000101">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000191">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049588">
        <property type="entry name" value="DHX8_GH2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049621">
        <property type="entry name" value="S1_DHX8_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF85">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="12">
        <location>
            <begin position="205"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="515"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="696"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="75"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="132"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="422"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="85"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="153"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="422"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK4044190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1170" mass="131131" checksum="389FC585962CB200" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PQI3</accession>
    <name>A0AAN6PQI3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Lysophospholipase</fullName>
            <ecNumber evidence="6">3.1.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_43729</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15177"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the lysophospholipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.5" evidence="6"/>
    <dbReference type="EMBL" id="MU854328">
        <property type="protein sequence ID" value="KAK4043424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PQI3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00147">
        <property type="entry name" value="cPLA2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002642">
        <property type="entry name" value="LysoPLipase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728">
        <property type="entry name" value="CYTOSOLIC PHOSPHOLIPASE A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728:SF40">
        <property type="entry name" value="PATATIN FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01735">
        <property type="entry name" value="PLA2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00022">
        <property type="entry name" value="PLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51210">
        <property type="entry name" value="PLA2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5 6" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4 5 6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="PLA2c" evidence="9">
        <location>
            <begin position="190"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="617"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="622"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="663"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="677"/>
            <end position="686"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4043424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="842" mass="93410" checksum="E62254E6ECD4FE21" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PQY2</accession>
    <name>A0AAN6PQY2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">SNF2 family N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_13089</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854328">
        <property type="protein sequence ID" value="KAK4043336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PQY2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF52">
        <property type="entry name" value="SINGLE-STRANDED DNA-DEPENDENT ATPASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="459"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="938"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="65"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4043336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1116" mass="123916" checksum="02B35C66D16DD799" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PRI0</accession>
    <name>A0AAN6PRI0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial carrier domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">C8A01DRAFT_32354</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854326">
        <property type="protein sequence ID" value="KAK4043621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PRI0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990547">
        <property type="term" value="P:mitochondrial phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000024">
        <property type="entry name" value="MIR1p Mitochondrial phosphate carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044677">
        <property type="entry name" value="SLC25A3/Pic2/Mir1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671:SF12">
        <property type="entry name" value="MITOCHONDRIAL PHOSPHATE CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 (MITOCHONDRIAL CARRIER PHOSPHATE CARRIER), MEMBER 3, LIKE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="16"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="114"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="212"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK4043621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="308" mass="32272" checksum="D5FA6D170F5A1B21" modified="2024-10-02" version="1">MAAKVDTPAPQLSGLQLYSRFALAGAVCCSVTHGALTPVDVVKTRIQLDPVTYNNGLLGGFKKVVQAEGAGALLTGVGPTFAGYFLQGSLKFGGYEFFKQQSINLLGYDNASQYRTGVYLASAAAAEFFADIALCPLEATRIRLVSEPTYASGLVSGFGKMLKQEGVGAFYAGFGPILFKQIPYTMAKFVVYEKVAEAVFRVFPKKDMSDGMQTAANLGSGLVAGFAAAIVSQPADTMLSKINKSKGAPGEGTTSRLIKIAKELGIRGSYAGIGARLFMVGTLTAGQFAIYGDLKKMLGATGGVEISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PRY9</accession>
    <name>A0AAN6PRY9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_31812</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854321">
        <property type="protein sequence ID" value="KAK4044204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PRY9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4044204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="165" mass="18769" checksum="5A44683AAEB5D87E" modified="2024-10-02" version="1">MANTPDDRAILGFHITFEPRVHIEFSTKRQAEAYLDKIKKRSVYIINALDGQQDGVHGNIMSIRLPSRIVCASMRNSRTYLTFSDKQLAKDWVKGLGIWEFLDDGKGNLSEFDVALMTGLSNKRLNKSLQIEEDRPQQRTILPRTHQRQAGNKVPGVAMRSTERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PT90</accession>
    <name>A0AAN6PT90_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Mitochondrial pyruvate carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">C8A01DRAFT_42856</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Mediates the uptake of pyruvate into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 18">Mitochondrion inner membrane</location>
            <topology evidence="2 18">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 18">Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the snRNP SmB/SmN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854319">
        <property type="protein sequence ID" value="KAK4044431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PT90"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070990">
        <property type="term" value="F:snRNP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006850">
        <property type="term" value="P:pyruvate import into mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01717">
        <property type="entry name" value="Sm_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000047">
        <property type="entry name" value="Small nuclear ribonucleoprotein SmB, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005336">
        <property type="entry name" value="MPC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050914">
        <property type="entry name" value="snRNP_SmB/NAA38-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701:SF0">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B AND N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03650">
        <property type="entry name" value="MPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="13 18" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10 18" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="15" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="17" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6 18" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Sm" evidence="20">
        <location>
            <begin position="2"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="152"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="56"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="19">
        <location>
            <begin position="157"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="19">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU363100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAK4044431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="343" mass="35541" checksum="8FE6751D168BD553" modified="2024-10-02" version="1">MSATNKQGKMINYRMRVTLNDGRQMTGQMLAFDKHMNLVLADTEEFRRSKRKQNKPAAPGASSAAVVEQEEKRTLGLTIVRGAHIVSLSVESPPPADPSARLGKTTGAGLTAGLTAGPGVARPAGRGAAAPISLAGPAAGVGGAAPPGFPSFPGAPGFPGRGGPAPPGFGGAFPPPAGFPGAPGFPPGFPPGGAPPSGQRQRSITVKMAAFVKAVNAKIRAHPVLNYVCSTHFWGPVSNFGIPVAAVMDTRKSPDLISGPMTFALCVYSATFMRYALAVTPQNYLLFLCHFVNEGAQLTQGYRYLQWTQWGGREQAALGAVGAAAKDKVGEVEGKVKELVGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PUA6</accession>
    <name>A0AAN6PUA6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_31223</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854317">
        <property type="protein sequence ID" value="KAK4044725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PUA6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4044725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="139" mass="14292" checksum="7B0FC8AB91C18909" modified="2024-10-02" version="1">MDGPSRTPFPTPQPLGPVRAATSPEEGTPQSSSTMASGPFFSASSISSGGYYDSPTSTSSTASTLLWGGSSGGRKDSTESAPASTSAAAAEAMMLTKRESAFAVSPKHVNANSYCGRHSKEFLFGGKGFGDLWRAVTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SL37</accession>
    <name>A0AAN6SL37_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BAH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_51564</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854882">
        <property type="protein sequence ID" value="KAK4031318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SL37"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04370">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001025">
        <property type="entry name" value="BAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46364">
        <property type="entry name" value="OS08G0421900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51038">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAH" evidence="2">
        <location>
            <begin position="97"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4031318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="446" mass="50274" checksum="4983B62C82C54AB1" modified="2024-10-02" version="1">MVSARKRHRAEPADSRAEHPFIIMMVDPKEKEQKKKKRRRVKNGKDDTTQRISLQMSPFAPCDKFKTNETMDLNYRVDPAEKWTGMTRYNSFVLNGVKYFSECFIHVANDSSIKRQKAVNNNDPMQRRENDEHHVYTRVYWMYWPDELPQGTHDGKKTVQGRQPYHGMNELIASNHMDIIDVVSVTSQAQVKQWYEENDEEIQHALYWRQAFDVRTYELSSVELVSRCNTPGDPDKMLIGCTEESCKEWMHEQCIIDDALRRTYKLLGTDNPHLPPAITKNEESGDEGKRPLNSIETGTGSSTEHSITVEATAALSDAVHVGIKDNIEVRQPADGEAASAAPEDSLPLQPPEAQATSENTNADTTSNPATAGESTPGRKPARLLKKGSEANGESARPWEGLFGAALKMADMGPPLIEFKDLREGVVGGEKTWTERVKCLLCENQVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SLI2</accession>
    <name>A0AAN6SLI2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_21084</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854709">
        <property type="protein sequence ID" value="KAK4031753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SLI2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4031753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="68" mass="7581" checksum="35C48F2FAB4FDE38" modified="2024-10-02" version="1" fragment="single">IEILVFCFYLPKDKGNLSVNAILTELGLLYLASSRINDVTGTSSTANILINLRTRVDITEKKVNDILR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SLK6</accession>
    <name>A0AAN6SLK6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mob1/phocein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_51232</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854697">
        <property type="protein sequence ID" value="KAK4031812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SLK6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.30">
        <property type="entry name" value="MOB kinase activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005301">
        <property type="entry name" value="MOB_kinase_act_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036703">
        <property type="entry name" value="MOB_kinase_act_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22599">
        <property type="entry name" value="MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03637">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01388">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101152">
        <property type="entry name" value="Mob1/phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="17"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605301-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4031812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="367" mass="40263" checksum="A47315BEB7FF5370" modified="2024-10-02" version="1">MSNLFSGINARFRGQRSPNSPGTSSPGPEQQALAQAQQAQLQAQAQGQAPAQSPVNPPHGHQGRQGSQSSSSSLAVKLPPLPTSPSLAETIGMDQTSGMVPSAEEVLASYHLPPVKPLWLNANYAKHIVKGNFLTLSAKPKTVEMGEWIAHQVVDHWRMLITFIRLVHDKEEDGSSICNSRKCSKMSAGGNHSFTWLNSRYQPVEIPAYEYLTLVQRYISGKIDDGAIFPTDPAGVSYADNSAFCPPVAESGQEWVGKRSGFPQNFMETCQTIFRQMFRVYAHLYWSHFDDMFSLNLEKSMNSCFSHFILTATTLNLLKKSDLEPMQPLIDLWAALGTFPQGSKAFEIANLQVGQLLVQKAGGPPAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SM16</accession>
    <name>A0AAN6SM16_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_40159</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854534">
        <property type="protein sequence ID" value="KAK4033371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SM16"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="49"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4033371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="297" mass="32640" checksum="DDF5F39E227D7003" modified="2024-10-02" version="1">MSTLHEEPEDIVRLIARTFPPPPTEPLQRNDRAGRIPEQTALADRPSSLGQLDRLPSEILSLVIGMLDIQAVARMGQVSFHGHLLVRSHPQYRDLEKFIPDVLAVLVLLGIADVHSLSPAYRTLFPENAKKILGLSDAHLQQLPTLRVPPRGYWPPKFARKGCRLVSMRAARELAISAGLAVPGVDAEEDKPLPPSKPKPDGSYGMATIRFPSVSPAGVVEEGLWCYGCQFLCDQYTHTKDGGFRQMLEELAARYPTPESTKRPVAVLQLRARPRAPCSWSTRTSATARSGCSASPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SMI6</accession>
    <name>A0AAN6SMI6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_20186</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854574">
        <property type="protein sequence ID" value="KAK4032802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SMI6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4032802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="167" mass="17433" checksum="F49517E9226EBB23" modified="2024-10-02" version="1">MSRFPIRPHAMPSISMLVSASRRPGSAATLRATASTSLWPYSNGNTSSPKSAEEPSATSGGSRSKEAAETGPSPTGGVIPDQLAGGDARGKTGGGPPLESSRHAPAQPKISNASVPGEHAKLSPEQQAEVDEHNRDFDKKHGIADRAGDDKVDKSFWSGKGSRYNKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SMJ5</accession>
    <name>A0AAN6SMJ5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_50473</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854573">
        <property type="protein sequence ID" value="KAK4032817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SMJ5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23703">
        <property type="entry name" value="mS26_PET12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058940">
        <property type="entry name" value="mS26_fungi"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26163">
        <property type="entry name" value="mS26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4032817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="317" mass="34541" checksum="1B317EB0D31B6275" modified="2024-10-02" version="1">MASPLSRPSICGLQTALSSCRISTTTTSKTTTTSPWRAFSTTPFAAQALAVPPESPRFITVPEPPQSAEPRPPPIKGHLPVPRDQFPRREGNRKVKPGYIAAVTSVSKSELAGQPPKSEEEARHRVFAAARRAAFTSGINGLYVRKSQREQRLHARSERRRTANQAAATAPERLDDVLTRPTVRAATALQTTVAPDPNRFAKAEAARAQHQQQTDLKAEARRDALAQLYVAAQRFIIDEAELEARVDAIFTADYHRVGGINRGQSIWDQDAAPVSVADMQAERTGSSTRAIDANKPIVVKTTKRQKAVAEELTGGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SMZ4</accession>
    <name>A0AAN6SMZ4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Tryptophan synthase beta chain-like PALP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_19443</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854518">
        <property type="protein sequence ID" value="KAK4033629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SMZ4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008721">
        <property type="term" value="F:D-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030378">
        <property type="term" value="F:serine racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018114">
        <property type="term" value="F:threonine racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01562">
        <property type="entry name" value="Thr-dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000005">
        <property type="entry name" value="Threonine dehydratase catabolic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43050">
        <property type="entry name" value="SERINE / THREONINE RACEMASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43050:SF1">
        <property type="entry name" value="SERINE RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
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    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="9">
        <location>
            <begin position="65"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4033629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="366" mass="38987" checksum="72328837D6F65321" modified="2024-10-02" version="1">MADPSTAPPLTRASVQAAHKLIEPYIHKTPVLTNSTLDRLASTPRADAELEGTEWAGRTPAKPVLRFWFKCENFQKSGAFKARGAFHAIERLKQEPGWAEGGGRERGVVTHSSGNHAQALSLAATTSGIPAHIIMPTISAAPKIAATRAYGGTITFSGPTAPERESTAAQVQSQTGARLVPPYNHPDIILGQGTAALELQSQIPPPTTLDAIITPCSGGGLLSGTALACHETGIHVFGAEPSFQGADDGRRSFLSGTRIDTVKSATIADGLRTPVGPIPWGIIYERKLVRGMYSVSEDEIKKAMRMVYERMKIVVEPSAVVGLAVAMFNEEFRGMVEREGGEEGWDLGVIFSGGNVNLDVLGELIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SN41</accession>
    <name>A0AAN6SN41_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kinetochore Sim4 complex subunit Fta4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_19805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854544">
        <property type="protein sequence ID" value="KAK4033225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SN41"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031511">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025207">
        <property type="entry name" value="Sim4_Fta4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42040">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42040:SF1">
        <property type="entry name" value="INNER KINETOCHORE SUBUNIT FTA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13093">
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    </dbReference>
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            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4033225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="277" mass="30162" checksum="AE1D8E447D683666" modified="2024-10-02" version="1">MAPTPPTVLSLKQSFLTTQTRLLSQPLTPTRAWLSSNNNSNTNNKTQDEEALPSKALDDALFKLNHRLQQHARRAYAPQATRHVAEQIDQLYWNAAAERDGEEDGEDENGGEGLELGADLADPKVIATLPLEWEDPSSSSSSQPLEAKRYAELAGELHALAEGKQQATARVARLRRMQALLEPFSANPSDGNGDGDGDGALGGVQENLVTRNGEVEAELHRMRMLLARVGGRVGQLKEEGQQARESSAGSLFSDRGGGVDDVEMDEQRKVGLLLERF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SN50</accession>
    <name>A0AAN6SN50_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glucarate dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_19672</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854534">
        <property type="protein sequence ID" value="KAK4033388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SN50"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042913458" evidence="2">
        <location>
            <begin position="19"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4033388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="291" mass="32469" checksum="AC109C019DDB2BCF" modified="2024-10-02" version="1">MKLETLLTAAWLASTATAIGPATPEQPPRLQGRAEKLSAWRWPNPFTSPKHKKFTPSCAVERTFQASQYLLDDLADKGPGGLLAYRDALKSVFSAREYPGSWDGVDPHGYDRDLLTMPYDEMPLKVREWIEEQERTDGKGKGLFAVYQVPLAGTRVLNTIKVPEEAPVSEEWRARDERRIAIFAPGAVYEVLPLWVAEGSECEESLLDLSKYSAQLVDGGVVAYPVHHSVPKRSKGLRDIEFQVKAQVLKLNEGEDAAADAEEDAQKTEKVEEVEKKAEKGEEKSSEKEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SND3</accession>
    <name>A0AAN6SND3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_39498</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854498">
        <property type="protein sequence ID" value="KAK4034019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SND3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4034019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="388" mass="41919" checksum="BB4CEE40F734D74D" modified="2024-10-02" version="1">MPRQLPWKVGIGATKQSSSRPKAAAASPAPSASRSPAPSHRPAPAPKPGATPDTARTARRSLGLSLARSPSTSPAPEPLKEELMIEGIDHDDQYRMVEDEFLAVAGEFTRHLHTAEYQRLKGLAKSQNADTIQNISRPVTGGMTDLVKRRHAALDTASKQRKGIAKTLGKRAAGNESDGEEPSRRPATSLQGLMNSPRKQTVPLTSVAGSRPGSSYRGAADTSPSRQRPSGHGTRMVRNHSIDMPAPADGAPSARFKPEPTLDSDDDDDDDLDGQPPWPRKPALPRPEKTVKPPIQRLSALKAPSRTISEPTSSDAGNPFTRAGTTRLQTSAQETSVEQVAADDDDEDDFFSRLRARRAEQKRRRETKAQDNNTKTSDTSAINSIPFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SNW7</accession>
    <name>A0AAN6SNW7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_18615</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAK4034604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
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                <person name="Natvig D.O."/>
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                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854435">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
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        <property type="entry name" value="PROTEIN PHOSPHATASE SLINGSHOT HOMOLOG 3"/>
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    </dbReference>
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            <end position="49"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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        </source>
    </evidence>
    <sequence length="114" mass="12868" checksum="FC98DB610B7E9C7B" modified="2024-10-02" version="1">MGISRSTTVVIAYLMRKTGKPPDEVLRHVKEKRKVRPNPNFMEQLRVWGEVGYQIWEDEECTVPKGPYRLYLEGRAVRLKEKGLTGNEPTLASAAAGHTCAERGVMTSGSERHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SPT4</accession>
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            <fullName evidence="6">GRIP domain-containing protein</fullName>
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        <name evidence="7" type="ORF">C8A01DRAFT_48482</name>
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    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Kuo A."/>
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                <person name="Riley R."/>
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                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
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                <person name="Natvig D.O."/>
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                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
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                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854449">
        <property type="protein sequence ID" value="KAK4035277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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    <dbReference type="InterPro" id="IPR000237">
        <property type="entry name" value="GRIP_dom"/>
    </dbReference>
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        <property type="entry name" value="MYOSIN HEAVY CHAIN - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18921:SF2">
        <property type="entry name" value="THYROID RECEPTOR-INTERACTING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10375">
        <property type="entry name" value="GRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GRIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GRIP" evidence="6">
        <location>
            <begin position="447"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
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    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
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    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="570"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="306"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
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            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
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    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
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            <begin position="86"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="234"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="544"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4035277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="601" mass="65243" checksum="451B218FBF473F18" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SQM7</accession>
    <name>A0AAN6SQM7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_47881</name>
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    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854427">
        <property type="protein sequence ID" value="KAK4038483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SQM7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08276">
        <property type="entry name" value="MDR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052711">
        <property type="entry name" value="Zinc_ADH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C1773.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="18"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4038483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="346" mass="37106" checksum="48DC9CBD52E84885" modified="2024-10-02" version="1">MSLPTTQKQWLISGTGKGFDSLLFQDAPVPKIGDNDVLVKLHGASLNYRDLLIPQGKYIFPLRLPIVAGSDGAGEIVAVGPSVTKWKAGDRVATLFNQGHQAGAIDVAASKTGLGGCIDGTLAQYGVFDQDGVVRMPANLGFVEAATLTCAALTSWNALYGLRRLRRGKTVLVQGTGGVSLFALQFAKAAGATVIATTSSAEKADVLKRLGADHVINYREDPNWGETARRLTPNGEGVEHVIEVGGEGTMTQSLHAIKMEGVISIIGLLSGANPKDNIMETLSRLCTIRGVYVGSREQMEEMVAAMEEHDIHPVVDDKVFTLEQAKEAYEYMWAQKHFGKVAIKIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SR83</accession>
    <name>A0AAN6SR83_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SYO1-like TPR repeats domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_36946</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nuclear import and ribosome assembly adapter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854410">
        <property type="protein sequence ID" value="KAK4039113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SR83"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13394">
        <property type="entry name" value="Syo1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052616">
        <property type="entry name" value="SYO1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057990">
        <property type="entry name" value="TPR_SYO1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13347">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13347:SF1">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25567">
        <property type="entry name" value="TPR_SYO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SYO1-like TPR repeats" evidence="3">
        <location>
            <begin position="438"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="347"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="533"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="363"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00049983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4039113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="684" mass="74022" checksum="093607E3EF94A145" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SR86</accession>
    <name>A0AAN6SR86_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_15970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854384">
        <property type="protein sequence ID" value="KAK4040114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SR86"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042950450" evidence="1">
        <location>
            <begin position="17"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4040114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="142" mass="15332" checksum="8AE0EF997734B68C" modified="2024-10-02" version="1">MKYIAAALVLAVSAIAAPSEKREACTFGKYRCTNPNTGIEICNVSNQWELVGPCPDGTACENLPQNGFELPFCTNTAKVQARNGRPGQSPGEKCQTPGKYDCFGPYAIQVCDTQNTLQFVGNCPERSHCEYLNGIPYCVASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SSQ6</accession>
    <name>A0AAN6SSQ6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Autophagy-related protein 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">Autophagy-related E2-like conjugation enzyme ATG3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">C8A01DRAFT_15434</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATG3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854371">
        <property type="protein sequence ID" value="KAK4040701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SSQ6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019776">
        <property type="term" value="F:Atg8-family ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061723">
        <property type="term" value="P:glycophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044804">
        <property type="term" value="P:nucleophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007135">
        <property type="entry name" value="Atg3/Atg10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12866">
        <property type="entry name" value="UBIQUITIN-LIKE-CONJUGATING ENZYME ATG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12866:SF2">
        <property type="entry name" value="UBIQUITIN-LIKE-CONJUGATING ENZYME ATG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03987">
        <property type="entry name" value="Autophagy_act_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK4040701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="341" mass="38091" checksum="57AFCD2286B4875C" modified="2024-10-02" version="1">MNIIYSTVNSLRDRYTPASHTSTFRKTGEITPEEFLAAGDYLVFKFPSWSWSDAEIPSKRISHLPPGKQYLVTRHVPCHRRLNDDFAGDAGHEEAVVEGGKNSDDDGWLRTGGLTSSQPLKVREVRTVDDAGNVGDREVIDEDDIPDMEDEEDDEAIIREPEGDGKNSGRRTYNMYIVYSPWYKTPRMYMSGYHPGGHPLAPHLMMEDIVGDYKDKTVTLEDFPFFAMNVKMASIHPCKHAPVMKTLLDRADAALKLRRERQKAGQAAGSSQGLEGLEGQIGNLNVGGADATSDNNEEWEEVQHDAADQEVAIRVDQYLVVFLKFIASVTPGIEHDFTMGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SSV6</accession>
    <name>A0AAN6SSV6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_14425</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854349">
        <property type="protein sequence ID" value="KAK4041914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SSV6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013694">
        <property type="entry name" value="VIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45737:SF4">
        <property type="entry name" value="VON WILLEBRAND DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_4G01160)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45737">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08487">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13768">
        <property type="entry name" value="VWA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00609">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51468">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VIT" evidence="3">
        <location>
            <begin position="100"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="406"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="778"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4041914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1066" mass="117704" checksum="0E5AD9AD5237A4C7" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6ST21</accession>
    <name>A0AAN6ST21_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_34464</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854356">
        <property type="protein sequence ID" value="KAK4041512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6ST21"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042874024" evidence="1">
        <location>
            <begin position="21"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4041512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="138" mass="14202" checksum="90B6801887C8C10D" modified="2024-10-02" version="1">MVRLHLAILPALLGATQVLATASTSQPVDSNIILPPTYTGGPWCTLSTTGAAAAETASFYDNPFPATLKQCRRPPLKCDCGLNSTEMAELDAERAKHGCHKCDCDRPENAAGRVAAEGGLVAAGVAAIVGVVGVMVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6STA8</accession>
    <name>A0AAN6STA8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">YT521-B-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_44617</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854342">
        <property type="protein sequence ID" value="KAK4042364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6STA8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990247">
        <property type="term" value="F:N6-methyladenosine-containing RNA reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21134">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.590.10">
        <property type="entry name" value="ph1033 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007275">
        <property type="entry name" value="YTH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045168">
        <property type="entry name" value="YTH_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357:SF3">
        <property type="entry name" value="YTH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357">
        <property type="entry name" value="YTH YT521-B HOMOLOGY DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04146">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50882">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YTH" evidence="3">
        <location>
            <begin position="568"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="108"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="432"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="710"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="394"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="115"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="168"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="190"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="303"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="321"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="432"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="473"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="534"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="570"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="711"/>
            <end position="725"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4042364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="732" mass="78963" checksum="F4E767E8567F1532" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6STP9</accession>
    <name>A0AAN6STP9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_44250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854336">
        <property type="protein sequence ID" value="KAK4042754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6STP9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4042754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="403" mass="43488" checksum="256D21C001A83D0B" modified="2024-10-02" version="1">MSPPYESSRRRGVWSHWVPLAVTVTVATVGVAAWAWSLRKDEDHQDTEQPAAYQDLDYDNADYGDNPAYGASKDGADPKAPTSGGAQPRSGDAVESSSSGWAALRRSPSPQQFFDSARRTVAAGVTAAGAAVGSALAAIREEDKTAYADHETWSEEADAKQDRAAGPSQSSKDANKRRKKVAIVISADNHLDDMDADGFHEHASILSHIPLQLDHSKIKLYVLIYAPNLKDANLDAASNLPPPSLSSSFSNIDHAQAQVSEEARSPLVGASSSDPAFNAIYSQAQALVEKDSMILTFTSPNGHSHILRHIQPEVIYLQESLSGDNGSAVTNLQTWLRHDVILVVGAESGHGGLADSESEAEQPGKEKDVWWHREDRVGRGRGVVVVDGMRVQDDWARRVLGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SV61</accession>
    <name>A0AAN6SV61_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">C8A01DRAFT_43341</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Bud neck</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="MU854324">
        <property type="protein sequence ID" value="KAK4043777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SV61"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005940">
        <property type="term" value="C:septin ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000394">
        <property type="entry name" value="Serine/threonine-protein kinase HSL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.220">
        <property type="entry name" value="Fungal kinase associated-1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030616">
        <property type="entry name" value="Aur-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031850">
        <property type="entry name" value="Fungal_KA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043024">
        <property type="entry name" value="KA1_sf_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE IAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16797">
        <property type="entry name" value="Fungal_KA1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 13 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="130"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="603"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="775"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="937"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1044"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="603"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="658"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="828"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="857"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="940"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="950"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="979"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1052"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="278"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="282"/>
            <end position="283"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)" evidence="14">
        <location>
            <position position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAK4043777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1205" mass="134554" checksum="5DF18B8134C75381" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SVC0</accession>
    <name>A0AAN6SVC0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_31504</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854319">
        <property type="protein sequence ID" value="KAK4044449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SVC0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="162"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="100"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4044449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="281" mass="30093" checksum="B3A419657B0E5F40" modified="2024-10-02" version="1">MGLLDDAASVISARTSHSKRSKSHRSSRHSHHHKDRSKSRSRSRSRSRHRSSRSNVGVGGTISGIAASIFGGDDDDDDHHHSSRRRSHHEKRHDEDGTRSFFNLPNPSKSSFFSNFGGRHSGSGSSHYRRSPRPGFVSRALKKLKRLLRDLLYYAKRHPLKVFMLVLMPLITGGALTALLARFGLRLPPFLERMLGVAARAGSGDSLGLVGEAVRMVSGAAGAGAGIAKASVERGRDGRGQWERRSLEGDFDGFGGFGGGGGGGGGWGAAAGLKGIAKMFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SVQ8</accession>
    <name>A0AAN6SVQ8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small COPII coat GTPase SAR1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Small COPII coat GTPase sar1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">C8A01DRAFT_12499</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPII-coated vesicle membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 22">Belongs to the small GTPase superfamily. SAR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854322">
        <property type="protein sequence ID" value="KAK4044015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SVQ8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00879">
        <property type="entry name" value="Sar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000161">
        <property type="entry name" value="Small COPII coat GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006687">
        <property type="entry name" value="Small_GTPase_SAR1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45684">
        <property type="entry name" value="RE74312P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51422">
        <property type="entry name" value="SAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="10 22" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11 22" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="13 22" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="14 20" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="18" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12 22" id="KW-0653">Protein transport</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 22" id="KW-0813">Transport</keyword>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="144"/>
            <end position="147"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004299"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00007507"/>
        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048548"/>
        </source>
    </evidence>
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        <source>
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            <dbReference type="PIRSR" id="PIRSR606687-2"/>
        </source>
    </evidence>
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    </evidence>
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            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU003926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KAK4044015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="204" mass="23049" checksum="7C46A931AC337CC7" modified="2024-10-02" version="1">MHDRPGEQEQNDANGYRSHLLVYDVLSSLGLLNKHAKLLFLGLDNAGKTTLLHMLKNDRVAILQPTLHPTSEELSIGNVRFTTFDLGGHQQARRLWKDYFPEVNGVVFLVDAKDHERFPEAKAELDALLSMEELAKVPFVILGNKIDHPDAVSEDELRHQLGMYQTTGKGKVPLEGIRPIEVFMCSVVMRQGYGDGIRWLSQYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SVR0</accession>
    <name>A0AAN6SVR0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_31400</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="term" value="P:intracellular distribution of mitochondria"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:peroxisome fission"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
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        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF66">
        <property type="entry name" value="INTERFERON-INDUCED GTP-BINDING PROTEIN MX"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="6">
        <location>
            <begin position="35"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="5">
        <location>
            <begin position="576"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="422"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="671"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="628"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="675"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="719"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="745"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="784"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="806"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="861"/>
            <end position="870"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4044347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="870" mass="97560" checksum="9C588F0D8AC76374" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SW28</accession>
    <name>A0AAN6SW28_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein eL39</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L39</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_31220</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL39 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854317">
        <property type="protein sequence ID" value="KAK4044722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SW28"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1620.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein-like L39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1620.10">
        <property type="entry name" value="Ribosomal protein L39e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00629">
        <property type="entry name" value="Ribosomal_eL39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000077">
        <property type="entry name" value="Ribosomal_eL39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023626">
        <property type="entry name" value="Ribosomal_eL39_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19970:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19970">
        <property type="entry name" value="RIBOSOMAL PROTEIN L39E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00832">
        <property type="entry name" value="Ribosomal_L39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48662">
        <property type="entry name" value="Ribosomal protein L39e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4044722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="51" mass="6251" checksum="1CBDCB00C354FE0D" modified="2024-10-02" version="1">MPSHKTFKIKQKLAKAQKQNRPIPQWIRLRTGNTIRYNAKRRHWRKTRLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P3W5</accession>
    <name>A0AAN6P3W5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleosome assembly protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_42249</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the nucleosome assembly protein (NAP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854907">
        <property type="protein sequence ID" value="KAK4031278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P3W5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.90">
        <property type="entry name" value="Nucleosome assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037231">
        <property type="entry name" value="NAP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002164">
        <property type="entry name" value="NAP_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11875">
        <property type="entry name" value="TESTIS-SPECIFIC Y-ENCODED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00956">
        <property type="entry name" value="NAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143113">
        <property type="entry name" value="NAP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4031278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="231" mass="27095" checksum="3FD53A6B3DD2B5B6" modified="2024-10-02" version="1">MATSLSQTTLDELADLERDFEEVEKKITRQHYCLSKPLYARLADLTARIPNIWGRMLKQALIDLDEYIQTSDLELLSHSLKSLSVTRFEIDADEKKGDPRSVAIRFEFANNKYFKDTVLEKRFWWRQNKYGFAGLVSEPVEIEWKKGKDLTDGRLGLTKAAFDEQQAKPDQELTGKRRALEEKIDETDIRDVSFFDWFGYIGEYISAEESRTVIDKEKEERRRRKVSRAQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P476</accession>
    <name>A0AAN6P476_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_51470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854806">
        <property type="protein sequence ID" value="KAK4031444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P476"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4031444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="232" mass="26850" checksum="ACB0FDD6DBC82CD8" modified="2024-10-02" version="1">MAAMMTMFQQFQQFLQTQAETQKQTNQLLKAQTQAVMASASHRKIQAIDKLTKQEDFPVWRDDILRVLKRAGLEEYVTTTVTEPEDEVGKTQWNNNRADIEEYIRAMVPGQKGDPKKAFDMVAQNFEKGSSDSNVKMAQELANIRRANFGKLEAFQLRINYLCDRLNDTKFKMDDEAYIWFCLKGIEKEYSSLYDRLVANVENGKLTWGELVMELQRLAVGENVQPAIVRYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P4M4</accession>
    <name>A0AAN6P4M4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein uS2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">RPS0</name>
        <name evidence="9" type="ORF">C8A01DRAFT_41902</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (25S, 5.8S and 5S). Interacts with RPS21.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6 7">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854738">
        <property type="protein sequence ID" value="KAK4031651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P4M4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01425">
        <property type="entry name" value="RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000010">
        <property type="entry name" value="40S ribosomal protein S0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03015">
        <property type="entry name" value="Ribosomal_S2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001865">
        <property type="entry name" value="Ribosomal_uS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018130">
        <property type="entry name" value="Ribosomal_uS2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027498">
        <property type="entry name" value="Ribosomal_uS2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005707">
        <property type="entry name" value="Ribosomal_uS2_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_uS2_flav_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01012">
        <property type="entry name" value="uS2_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11489">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN SA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00395">
        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
        <property type="entry name" value="Ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00963">
        <property type="entry name" value="RIBOSOMAL_S2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="244"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4031651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="294" mass="31907" checksum="052871CF8F3E08FA" modified="2024-10-02" version="1">MAPANLPSIFNATSTDIEQLLAAQCHIGSKNLGVNMQPYLWKTRADGVNVINIGKTWEKITLAARIIAAIDNPSDVCVISARPYGQRAVLKFAAHTGAQAIAGRFTPGSFTNYITRSFKEPRLIIVTDPRTDAQAIKEASYVNIPVIALCDTDSPTEYVDVAIPTNNKGRHSIGLVWWMLAREVLRLRGTIYNRETPWDVMPDLYFYRDPEAEAEEKVEEEKVPGVEEEGPVAIESGFQAGAGDWEAAPAGFPAATGEWSEAQPATWESGAAAATAPATEWAAESAPKETTSGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P595</accession>
    <name>A0AAN6P595_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">tRNA pseudouridine synthase 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">tRNA pseudouridylate synthase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">tRNA-uridine isomerase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">C8A01DRAFT_41555</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Formation of pseudouridine at positions 27 and 28 in the anticodon stem and loop of transfer RNAs; at positions 34 and 36 of intron-containing precursor tRNA(Ile) and at position 35 in the intron-containing tRNA(Tyr). Catalyzes pseudouridylation at position 44 in U2 snRNA. Also catalyzes pseudouridylation of mRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a uridine in mRNA = a pseudouridine in mRNA</text>
            <dbReference type="Rhea" id="RHEA:56644"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:14659"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a uridine in tRNA = a pseudouridine in tRNA</text>
            <dbReference type="Rhea" id="RHEA:54572"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13934"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>uridine in snRNA = pseudouridine in snRNA</text>
            <dbReference type="Rhea" id="RHEA:51124"/>
            <dbReference type="Rhea" id="RHEA-COMP:12891"/>
            <dbReference type="Rhea" id="RHEA-COMP:12892"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854662">
        <property type="protein sequence ID" value="KAK4032014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P595"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02568">
        <property type="entry name" value="PseudoU_synth_PUS1_PUS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.580:FF:000002">
        <property type="entry name" value="tRNA pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.660:FF:000002">
        <property type="entry name" value="tRNA pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041708">
        <property type="entry name" value="PUS1/PUS2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00071">
        <property type="entry name" value="hisT_truA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142:SF4">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pseudouridine synthase I TruA alpha/beta" evidence="17">
        <location>
            <begin position="399"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="578"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="578"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="594"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="14">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00036943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00053072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00073968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00079072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00080858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR641708-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR641708-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAK4032014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="607" mass="67623" checksum="821384DCFE35BD2E" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P5F0</accession>
    <name>A0AAN6P5F0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_20787</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854649">
        <property type="protein sequence ID" value="KAK4032103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P5F0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4032103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="304" mass="31663" checksum="513D127A83424C80" modified="2024-10-02" version="1">MGKSTTHLSAYPLAPEYSQLPEVAAGWSGAEAPELASADEAAKAARGFGASSWTPPQEQSQPLAPRSPLPIAVKSEPPDSGYPPSSATHDESRPRRTTVLILSILVGVLAAAVVGLATATGMMARRASNAESANPQPVVNGTVCPSVTVTTTTTATVVSATGTNVPTSSPVADVSNGCSAKNEKISGTTYTTQLFGKASFIRYCNTQPKQFPIYGMLTLDFEACMDACAAWSAHGADVIGKDNENSTCGGVRFVPAWTDRALAYERNARGNCFLQSAPQTADNLTKPDLQGDVTCHAAILVEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P5Z1</accession>
    <name>A0AAN6P5Z1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_42182</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854847">
        <property type="protein sequence ID" value="KAK4031355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P5Z1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="204"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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            <begin position="272"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="374"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4031355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="405" mass="45280" checksum="B150CEA524022E7A" modified="2024-10-02" version="1">MDAQLPPEAVGAAAGVLIYSFICLACGLLLLWLVSVHDERMSCKQHASWFDLRLLTTDVAMLGFFATLHTLASIAQQIHTIVRWREIKIAQYDHLVANVGNPELNQTGSSVGLDLVLFYIQYYAYNVESLLVLFWYAAGLLSTVLRLTFDPRAIELANSISQLRMTKMYRFHTTLVAKASAAILPILQLMLLHFTPIYRSSAGFMALSCGVMILCFSVGAIVLFIILARYILSRITLATWSVRYGRSSGGINGTSPDTPRLGPKRNIYDKWLVLRFSIGFAAMSLFQIVVINFQLRSAATNNAAKSRLLQTRTFGIPVLSEEDSTAMNGVNSKKLTTRLEREQAALPEREQQRVICRPSQHRLDTGKTGLAFPIAELSRKREECERLIDKAKDLDDALRKNEAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P791</accession>
    <name>A0AAN6P791_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 6">Phosphoinositide phospholipase C</fullName>
            <ecNumber evidence="1 6">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_20067</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
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            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
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            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="1 6"/>
    <dbReference type="EMBL" id="MU854563">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PH_PLC_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
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    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037755">
        <property type="entry name" value="Plc1_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF36">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00387">
        <property type="entry name" value="PI-PLC-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00149">
        <property type="entry name" value="PLCYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4 6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="PI-PLC Y-box" evidence="9">
        <location>
            <begin position="782"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="8">
        <location>
            <begin position="900"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="99"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
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            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1085"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="99"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
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            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
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            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1096"/>
            <end position="1111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4032935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1111" mass="124437" checksum="5D006BEBB877C2F9" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P796</accession>
    <name>A0AAN6P796_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_19947</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854554">
        <property type="protein sequence ID" value="KAK4033064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P796"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4033064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="206" mass="22968" checksum="87EF3E577DD12723" modified="2024-10-02" version="1">MAVVLGIAIVRCLARDPDTNSPDGPSPEDLEAVCDAHGHLQLLASCPGDPITAFEILMLDPSARPFFPRKASLPRPEMWHDEIYDTVMAPYTAMAEAMERHDGRGGDAHNKQYMIALTRSADLLLKDGPRRYYLDTVLPMLERAIQGQPRQCVWPSVSEFNHNLCAGSWSGTGVADLLRDHHISHDHRCVDGFGILDWLERLGLWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P7B5</accession>
    <name>A0AAN6P7B5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_21119</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854720">
        <property type="protein sequence ID" value="KAK4031718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P7B5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042991453" evidence="3">
        <location>
            <begin position="26"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="240"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="489"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="496"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4031718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="593" mass="59727" checksum="6240D0DD48EFF164" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P836</accession>
    <name>A0AAN6P836_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">1-alkyl-2-acetylglycerophosphocholine esterase</fullName>
            <ecNumber evidence="1">3.1.1.47</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_19634</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.47" evidence="1"/>
    <dbReference type="EMBL" id="MU854532">
        <property type="protein sequence ID" value="KAK4033415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P836"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003847">
        <property type="term" value="F:1-alkyl-2-acetylglycerophosphocholine esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10272:SF14">
        <property type="entry name" value="PAF ACETYLHYDROLASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10272">
        <property type="entry name" value="PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03403">
        <property type="entry name" value="PAF-AH_p_II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042817613" description="1-alkyl-2-acetylglycerophosphocholine esterase" evidence="5">
        <location>
            <begin position="17"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4033415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="397" mass="42680" checksum="AC15622BEAD78E03" modified="2024-10-02" version="1">MRFTLLASLLLGAAQAVVVPSHPGPFSVAMRVKALTDHGRTDPFNGTTKRQVLLSVFVPILDNIKCSQDVVSYMPPATAASYGPLAESAGLPGALFSTFQLEFCKPPQQNESCRASKKRGPRFPLVFFSPGLGESRLLYSVTAKSIAAQGYVVVTVDHPYDAEVIEFPDGSVVRRNWTTGMEQQLTEFRAADISFALTKLGQLTQNGGPLFRDLPTTHIDLTRVIAMGHSLGGAAAALAVRQDRRIHGGIDLDGRLFSPVLESGLNTNSKKTNQPFMLLGREKHADEDATWNQFWRVLSSGTGGSGGKGAMVAVKGTSHFSFADLPPLIQALGLPDEVKGQVEAMLGVVDGARMQRILAEVSASFFEWAFEGSYGRFEEAVGGFAEVVVRNSSFSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P895</accession>
    <name>A0AAN6P895_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cyclohexanone monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_40965</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854593">
        <property type="protein sequence ID" value="KAK4032585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P895"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050775">
        <property type="entry name" value="FAD-binding_Monooxygenases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098:SF2">
        <property type="entry name" value="FAD-BINDING MONOOXYGENASE AUSB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13738">
        <property type="entry name" value="Pyr_redox_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4032585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="545" mass="60547" checksum="35F0E07930A482AE" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P8D6</accession>
    <name>A0AAN6P8D6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ras-2 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_39901</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Ras family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854518">
        <property type="protein sequence ID" value="KAK4033634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P8D6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
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    </dbReference>
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        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
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    <evidence type="ECO:0000256" key="1">
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4033634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="237" mass="26512" checksum="17571D387269F034" modified="2024-10-02" version="1">MAGKMVLYKLVVLGDGGVGKTALTIQLCLQHFVETYDPTIEDSYRKQAVIDNQACMLEVLDTAGQEEYTALRDQWIRDGEGFVLVYSISSRSSFTRIKRFHHQIQRVKESTASSPSYPGSPISAANPSAPVPIMLVGNKSDRIAEREVSTQEGHALARELGCEFVEASAKNYINVDKAFYDVVRILRRQRQAASLPLSPTGTSKYESSRRTDSNVQSEKGRHRRERGERRSRGCVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P8G5</accession>
    <name>A0AAN6P8G5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_19421</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854516">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP001303115">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36156:SF2">
        <property type="entry name" value="CUPIN TYPE-2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36156">
        <property type="entry name" value="SLR2101 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4033679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="199" mass="21405" checksum="8A4E1808B1F31BBC" modified="2024-10-02" version="1">MSSYNLTAPRRITASNLPLPSNYQGDEHAEPGVEIKVDSLKVDALLDGTLMRSVVATSKQIPTSNDGHGELPLDEVPGMGIVLPGGLNMYYIDLAPNTEGTMHRTTSTDYLVLISGKLSLLTPSPEPYQVKDGKATYGEPVETVCHAGDVVAQRGMMHALSNRTNEWVRLLAVVLSSETNKVPVEGADGHKELPDAWLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2025-10-08" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P8I5</accession>
    <name>A0AAN6P8I5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_40785</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854577">
        <property type="protein sequence ID" value="KAK4032767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13037">
        <property type="entry name" value="FORMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13037:SF24">
        <property type="entry name" value="POLYCOMB PROTEIN PCL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0945">Host-virus interaction</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="24"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="93"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="215"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="602"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1030"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="239"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1079"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1114"/>
            <end position="1127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4032767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1325" mass="144636" checksum="B8712C7F3F7D95D7" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P8V7</accession>
    <name>A0AAN6P8V7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_39648</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854505">
        <property type="protein sequence ID" value="KAK4033879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P8V7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052234">
        <property type="entry name" value="U5_snRNP_Component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44006">
        <property type="entry name" value="U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 40 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44006:SF1">
        <property type="entry name" value="U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 40 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="121"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="273"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="358"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="358"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="381"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4033879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="395" mass="42789" checksum="28121026325BFA75" modified="2024-10-02" version="1">MQSADPEHFFETDAAQEKRQRRAAKAGNKYGNPISLKSKILAAIPDPRSPSSALLVAESAGAVRLVKLNDPEDTKTAYRGPTAPVCSVAVGGPHAGTLFAGSWDKNIWSWDLASKTPRRKYVGHTDFVKAVVCATAGGKDLLISGGADKKIMVWDVATGARLHTLQDGAVNMLSIQDLAVDHASSAADEISLISASSDPHIRRWKIRLDGWEQVVEASPDAPGTDRRTILEHETTVYKLVLDHDGDEVDLWTSSGDGTAKCLSRMRNFSCEDTFHHGDHVRAVAVTEQWVITAGRDEDIKFWDRTSGKLHCSLVGHYDEVTELVVLRGPSGSGDRVCSVSIDGTVRTWPLEKAGLDAAVKEQEKPVEEEKKEAGGDGLLSAEEEAELAALMDDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P919</accession>
    <name>A0AAN6P919_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dipeptidyl peptidase III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_49590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854503">
        <property type="protein sequence ID" value="KAK4033925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P919"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039461">
        <property type="entry name" value="Peptidase_M49"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23422:SF11">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23422">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE III-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03571">
        <property type="entry name" value="Peptidase_M49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4033925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="665" mass="74454" checksum="3657C2DC869D7DC5" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P956</accession>
    <name>A0AAN6P956_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protoglobin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_19073</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854497">
        <property type="protein sequence ID" value="KAK4034051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P956"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044398">
        <property type="entry name" value="Globin-sensor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42071:SF1">
        <property type="entry name" value="GLOBIN-SENSOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42071">
        <property type="entry name" value="PROTOGLOBIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11563">
        <property type="entry name" value="Protoglobin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Globin-sensor" evidence="2">
        <location>
            <begin position="22"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4034051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="296" mass="32863" checksum="A3A949E0A73E1BF0" modified="2024-10-02" version="1">MSTARTRPMQHIDRKSLYTNLEARIRYLHSFLDFGASDIEALRSGSKYIQALIPAVVNIVYRKLLQYDITARAFQTRSTAFEGPMDAEPDELSPQILHRKSFLRAYLKKLCSDPTRMEFWEYLDKVGMMHTGLGRPHPLHIEYIHIGAGLAVIQDILSEAILSHPRLPLARKIAIVKALGKVIWIQNDLFTKWYVTDGEEFTDGVDYAALLEREGYLHGKRVLNPEEEEAQAEAGSEGIVCPGREGMEREGPLPVGVCPFTGVVAGMEGLRVKGEKAGSGLDGEGLKAGEGLVNGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P9J9</accession>
    <name>A0AAN6P9J9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_49345</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854489">
        <property type="protein sequence ID" value="KAK4034210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P9J9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24362:SF309">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24362">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE NEK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4034210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="263" mass="29868" checksum="233DB3A7993999DF" modified="2024-10-02" version="1">MGDVTPADDHEPEPEHEPWPPVPPDVDNATIDTEKTPISFSMNGQIYRVKGRPSEIFKYGAMEREYDLQAAAGECAIRVRGRVMAKYPFGIDFRGFLMDLATPIPKALPPSECRDLMHQMVSVVRKLHDKGIVHGDMKLDNMLLDNQGKLRLCDFGEGRYVDEDEAIWEGQSTWHYESPNRFARGERLGQDPPPPTIEDDLYSLGLSIWEFYTGQIPFEDLRMDDLGLKEKQREGETVDVDEVHDPEAREIIIGLLRTGGARI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PA37</accession>
    <name>A0AAN6PA37_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">1,3-beta-glucan synthase</fullName>
            <ecNumber evidence="3">2.4.1.34</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">1,3-beta-D-glucan-UDP glucosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">C8A01DRAFT_49115</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[(1-&gt;3)-beta-D-glucosyl](n) + UDP-alpha-D-glucose = [(1-&gt;3)-beta-D-glucosyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21476"/>
            <dbReference type="Rhea" id="RHEA-COMP:11146"/>
            <dbReference type="Rhea" id="RHEA-COMP:14303"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37671"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.34"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.34" evidence="3"/>
    <dbReference type="EMBL" id="MU854476">
        <property type="protein sequence ID" value="KAK4034533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000148">
        <property type="term" value="C:1,3-beta-D-glucan synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003843">
        <property type="term" value="F:1,3-beta-D-glucan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006075">
        <property type="term" value="P:(1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051278">
        <property type="term" value="P:fungal-type cell wall polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000059">
        <property type="entry name" value="Serine palmitoyl CoA transferase subunit LcbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026899">
        <property type="entry name" value="FKS1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056261">
        <property type="entry name" value="FKS1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003440">
        <property type="entry name" value="Glyco_trans_48_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12741:SF48">
        <property type="entry name" value="1,3-BETA-GLUCAN SYNTHASE COMPONENT FKS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12741">
        <property type="entry name" value="LYST-INTERACTING PROTEIN LIP5 DOPAMINE RESPONSIVE PROTEIN DRG-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14288">
        <property type="entry name" value="FKS1_dom1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23605">
        <property type="entry name" value="FKS1_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02364">
        <property type="entry name" value="Glucan_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01205">
        <property type="entry name" value="FKS1_dom1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="504"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="539"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="580"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="615"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="676"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="730"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1493"/>
            <end position="1512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1572"/>
            <end position="1605"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1611"/>
            <end position="1634"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1646"/>
            <end position="1668"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1710"/>
            <end position="1731"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1768"/>
            <end position="1792"/>
        </location>
    </feature>
    <feature type="domain" description="1,3-beta-glucan synthase component FKS1-like" evidence="13">
        <location>
            <begin position="347"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="151"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1814"/>
            <end position="1834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="56"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="89"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="168"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1814"/>
            <end position="1831"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK4034533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="2380" mass="270076" checksum="56A5B71DA0413721" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PA40</accession>
    <name>A0AAN6PA40_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_49133</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854477">
        <property type="protein sequence ID" value="KAK4034510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PA40"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF58">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="2">
        <location>
            <begin position="72"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4034510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="249" mass="27501" checksum="5D370A8984F70938" modified="2024-10-02" version="1">MMICEKVDSPESKPADTIVDWKGGESVLCLRSSSGNELCRGVGYVAADRVHVGGPSAAVHAWVEGIEQHDTIDDHDLDRKFLVTKRVEGQTLEQAWPWLSSPQRIRVADDVGRVCAIPAANTSSRFETVTGRSVHEPRPIDDAPKPHPTWKPRLFGPLSQERCLLTLGFTFYHADLGPTNVLVSDDGDRATGIIEWESGAYYPRFYVASKPASGAFGLECETEDPERWGQLLAEALQRHGYKVAAEYLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PAV3</accession>
    <name>A0AAN6PAV3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Metalloenzyme, LuxS/M16 peptidase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_50394</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854563">
        <property type="protein sequence ID" value="KAK4032931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PAV3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000015">
        <property type="entry name" value="Putative zinc metalloprotease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000031">
        <property type="entry name" value="Putative zinc metalloprotease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000036">
        <property type="entry name" value="Putative zinc metalloprotease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000042">
        <property type="entry name" value="Zinc metalloprotease, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43016:SF16">
        <property type="entry name" value="METALLOPROTEASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G07610)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43016">
        <property type="entry name" value="PRESEQUENCE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042851200" evidence="2">
        <location>
            <begin position="17"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="3">
        <location>
            <begin position="237"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1052"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1056"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1082"/>
            <end position="1091"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4032931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1091" mass="121346" checksum="DA363AE3A103FC7B" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PAX7</accession>
    <name>A0AAN6PAX7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_48742</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854459">
        <property type="protein sequence ID" value="KAK4034968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PAX7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4034968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="353" mass="39885" checksum="5A5382750C6C5849" modified="2024-10-02" version="1">MGTRFIRLKKSADATFGHRASITRKLAETIFAQFDVHNGFMGDLVGRPDYWSAVGRCKGKDVVPEEEFEFFCQHPRWAQVWRYEKAWDLPKSSQGHRAPCSVYMHHSKSRNLTFYLISASETEDWLPWLLQRIGVDGNHAGASREVLEALTSSPFMMHAVISTIAFEQSIEYVANVRERLMSQIKQVNDYSEQGSSSAPRTARARSGMEDRIMLESITKQLHLVSQTADTGIANSHASIKIAERMLEAHSMFMMTKERQKGVKGPAAVIVSDTHTALQYVRNSFYCQKDLLTTYKARKDTAMNFVFNMVTQQDSATNVDISYKMSQDSSSMNAVTVLTLIFLPGTFLSANCFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PB55</accession>
    <name>A0AAN6PB55_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ADP-ribose 1''-phosphate phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.84</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_49428</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Highly specific phosphatase involved in the metabolism of ADP-ribose 1''-phosphate (Appr1p) which is produced as a consequence of tRNA splicing.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ADP-alpha-D-ribose 1''-phosphate + H2O = ADP-D-ribose + phosphate</text>
            <dbReference type="Rhea" id="RHEA:25029"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57967"/>
            <dbReference type="ChEBI" id="CHEBI:58753"/>
            <dbReference type="EC" id="3.1.3.84"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the POA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.84" evidence="3"/>
    <dbReference type="EMBL" id="MU854494">
        <property type="protein sequence ID" value="KAK4034117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PB55"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140291">
        <property type="term" value="P:peptidyl-glutamate ADP-deribosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02901">
        <property type="entry name" value="Macro_Poa1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050892">
        <property type="entry name" value="ADP-ribose_metab_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12521:SF0">
        <property type="entry name" value="ADP-RIBOSE GLYCOHYDROLASE OARD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12521">
        <property type="entry name" value="PROTEIN C6ORF130"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Macro" evidence="8">
        <location>
            <begin position="109"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="47"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="94"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4034117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="282" mass="30706" checksum="F54180AFD04D6B17" modified="2024-10-02" version="1">MSDKRPATTTDASGGQRQFKQTKLNFFTSASERQPKKPRTTPEEPQETATAAAKETSATAHPEDQQPPSQTETSKTKTAEQATTPQDPSPAPTPITTTPQTNPSSARLRITDRTGDLFAAPPSTLLIHACNTLGSWGGGIAVAFRTLYPDAFKVYRAHCARSTPDQLIGTALLIPPQNGRGKKHYIGCLFTSRRYGKARDPPMVILQATVPAMRHLVELVVAEEERTGVKIGEVRMCRINSGLFAVPWERSKRALEEMELGEGEVPGCVEGGVVEVVAWERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PB60</accession>
    <name>A0AAN6PB60_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_49356</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854490">
        <property type="protein sequence ID" value="KAK4034190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PB60"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF10">
        <property type="entry name" value="TOL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="245"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4034190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="676" mass="76169" checksum="1F043325B7737F64" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PBS8</accession>
    <name>A0AAN6PBS8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Thioredoxin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_38008</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peroxiredoxin family. Prx6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854441">
        <property type="protein sequence ID" value="KAK4038049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PBS8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03016">
        <property type="entry name" value="PRX_1cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1020.10:FF:000001">
        <property type="entry name" value="1-Cys peroxiredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000011">
        <property type="entry name" value="Peroxiredoxin PRX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1020.10">
        <property type="entry name" value="Antioxidant, Horf6, Chain A, domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019479">
        <property type="entry name" value="Peroxiredoxin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045020">
        <property type="entry name" value="PRX_1cys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503">
        <property type="entry name" value="MCG48959-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503:SF4">
        <property type="entry name" value="PEROXIREDOXIN-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10417">
        <property type="entry name" value="1-cysPrx_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1 6" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="4 6" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="8">
        <location>
            <begin position="7"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity" evidence="7">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4038049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="221" mass="24739" checksum="B139F8AAED264FBD" modified="2024-10-02" version="1">MASSTPLRLGSTAPNFQAETTKGPIDFHEFIGDNWVILFSHPEDYTPVCTTELGEMARLEPEFNKRGVKLIGLSANTLGSHEGWIKDIDEVTGSLVNFPILADKERKIAYLYDMIDYQDTTNVDEKGIAFTIRSVFFIDPKKTIRTILSYPASTGRNSAEILRVIDSLQTGDKHKVTTPINWVPGDDVIVHPTIKGDEATKLFPNMRVVKPYLRFTPLPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PCH0</accession>
    <name>A0AAN6PCH0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_18374</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854462">
        <property type="protein sequence ID" value="KAK4034867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PCH0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4034867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="97" mass="10190" checksum="47EA7D0B8DBE8A68" modified="2024-10-02" version="1" fragment="single">AATDFGSCDPTIQFTGGLGGRPATEFTFQSNDPAIAANQQEALNPNIITNRICDELTNICDANQAAKDLCEDAQAQIQALGTRDASTAQAWNGLLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PCK2</accession>
    <name>A0AAN6PCK2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Probable alpha/beta-glucosidase agdC</fullName>
            <ecNumber evidence="5">3.2.1.20</ecNumber>
            <ecNumber evidence="6">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">C8A01DRAFT_49593</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Glucosidase involved in the degradation of cellulosic biomass. Has both alpha- and beta-glucosidase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>Hydrolysis of terminal, non-reducing (1-&gt;4)-linked alpha-D-glucose residues with release of alpha-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.20"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.20" evidence="5"/>
    <dbReference type="EC" id="3.2.1.21" evidence="6"/>
    <dbReference type="EMBL" id="MU854504">
        <property type="protein sequence ID" value="KAK4033891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PCK2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004558">
        <property type="term" value="F:alpha-1,4-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06602">
        <property type="entry name" value="GH31_MGAM_SI_GAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030458">
        <property type="entry name" value="Glyco_hydro_31_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030459">
        <property type="entry name" value="Glyco_hydro_31_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF67">
        <property type="entry name" value="ALPHA_BETA-GLUCOSIDASE AGDC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00129">
        <property type="entry name" value="GLYCOSYL_HYDROL_F31_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00707">
        <property type="entry name" value="GLYCOSYL_HYDROL_F31_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="14" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13 17" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="10 17 22" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0964">Secreted</keyword>
    <keyword evidence="9 18" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043031867" description="Probable alpha/beta-glucosidase agdC" evidence="18">
        <location>
            <begin position="19"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 N-terminal" evidence="20">
        <location>
            <begin position="90"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="19">
        <location>
            <begin position="273"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="21">
        <location>
            <begin position="719"/>
            <end position="807"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00025512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAK4033891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="918" mass="102419" checksum="A1DADB063EE9AA16" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PD02</accession>
    <name>A0AAN6PD02_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transmembrane proteins 14C-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_39438</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854495">
        <property type="protein sequence ID" value="KAK4034101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PD02"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1740">
        <property type="entry name" value="Transmembrane protein 14-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005349">
        <property type="entry name" value="TMEM14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044890">
        <property type="entry name" value="TMEM14_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12668">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 14, 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12668:SF15">
        <property type="entry name" value="UPF0136 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G03720)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03647">
        <property type="entry name" value="Tmemb_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4034101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="104" mass="10791" checksum="37F32FD99D8468FD" modified="2024-10-02" version="1">MGLEFPSYVLAALTAAGGAIGYVRTKSAPSLIAGTAVGLLYGLGGYRIDNSEPYGVELSLLASLVLGGSAFPRAIRLRKPVPIMLSVLAAYGLVTFGDAFRRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PD41</accession>
    <name>A0AAN6PD41_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Phosphatidylinositol glycan anchor biosynthesis class U protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_48015</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854431">
        <property type="protein sequence ID" value="KAK4038382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PD41"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009600">
        <property type="entry name" value="PIG-U"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13121">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13121:SF0">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN ANCHOR BIOSYNTHESIS CLASS U PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06728">
        <property type="entry name" value="PIG-U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="217"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="268"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="303"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="351"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="380"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4038382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="424" mass="46819" checksum="B793D2545277A270" modified="2024-10-02" version="1">MDAKVTPGRTAGLYAGAAVLRLAIFTLLPALPDLLTGRVEISTPVTSFKRLQEGLFLYNHNVSPYDGGVYHQAPLLLPLFSLLPSFTSLPIFTYLLYIAVDLLSAGALWRIADSGEAGSSALFTSPRREKRWSGFVVAAAFLLNPFTVATCIGRSTSVFTTCAILHAIAKAVSGAPFGAMVALSFASYLSMYPLLLLPPLVLLAYDRQRPERATKSALQFAAVSASTVAGVVGVLFQMSYLLTGSWEFLPSTYGVQLTLSDLTPNVGLWWYFFIEMFDSFRSFFLAVFWLHLSSYVGGLTVRIRRQPLVVLTLLLGIFAIFKPYPSISDMALFLALVPLHRHVFPLMRYTFVSAAVIMYATCLGPAFYHLWIYAGSGNANFFYAVTLVWNLGLSLLVCDLMFAVLRDEWEVERPEMAGKEIRQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PD86</accession>
    <name>A0AAN6PD86_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7905 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_48530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854450">
        <property type="protein sequence ID" value="KAK4035272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PD86"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="DUF7905"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25482">
        <property type="entry name" value="DUF7905"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="155"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4035272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="496" mass="55273" checksum="E3910A3749DF70D2" modified="2024-10-02" version="1">MMRKVFTSGADQVCKRPPPKLNVTVHVSWPAPMRGYKDLDPSDVDVSALLSRVAREHEAEIKAEEADSAVTVTVRATNRAKAQEIITILRGQLLYRPGEENVWRARPLAHPPSDGRDSLTVVLRSKEGTTGRRATAAATESGEPVGDVATKADYKKELAKTLDQTAGILRHNPNGMRMKVQFGTLIVHEWKKDKAEYTFAELESLLSRAGTRGTAQMLSTVSEAAAKALVDRLSLSNEELPDSVMSYLKAGDPIRVYSLILESKNLHLESTFEPVKGQQVRDKNAMRGPQYTLGPLTIHQLEKQHRAAEVITACPESVHDWGLEIRKSAVEQDTRPSPPFRVEELQQNVRFTGELLAQGFPNLVLRDHFLQRNHIQAVHGKTVFRYTLGNRYSLDINLFHQWQPRQAGQKTATMITTAAVLLYSNDWDDDMRAGVSVPRPWDDSFAKQFLQQGPTDEAPGGVAEEPLDHLLAWVEWIQKALDSALEKDGKATRDGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PDG7</accession>
    <name>A0AAN6PDG7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_17849</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854442">
        <property type="protein sequence ID" value="KAK4038008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PDG7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="3">
        <location>
            <begin position="555"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="555"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="150"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="233"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="282"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="468"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="613"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="717"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="741"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="792"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="13"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="92"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="233"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="257"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="522"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="534"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="625"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="722"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="792"/>
            <end position="802"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4038008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="878" mass="92359" checksum="038469DB27DBFD13" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PEC5</accession>
    <name>A0AAN6PEC5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF7732 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_16682</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854403">
        <property type="protein sequence ID" value="KAK4039341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PEC5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056634">
        <property type="entry name" value="DUF7732"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42091">
        <property type="entry name" value="CONSERVED GLYCINE-RICH PROTEIN (AFU_ORTHOLOGUE AFUA_7G02440)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42091:SF1">
        <property type="entry name" value="CONSERVED GLYCINE-RICH PROTEIN (AFU_ORTHOLOGUE AFUA_7G02440)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24866">
        <property type="entry name" value="DUF7732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042867697" description="DUF7732 domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7732" evidence="4">
        <location>
            <begin position="99"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4039341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="257" mass="26098" checksum="6C905CB212DCC6B2" modified="2024-10-02" version="1">MRFTSFFLATTLLSDVAVSVLVAPPAAEVATYHPQRDSSSHEDLWKRKGGGGGGGRGGGGSSGGSSGGSSGGSSGGNSGGRGGGSSGGRTTPTYGAGKYFGGGAATPYKSGRSSPSGIVPIFFAASFLAFWPGLWLYGAHYYPYHNPYRFYNQSSQNNETKPVSCACDAAQDCSCDENGDTQYMNDLIGNGSYDALNKTLVTVADVNGTSTILVNGTLPAGTADTDGSAAGDGFRALLHHAGWWPVAAAVCAIVFTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PFC5</accession>
    <name>A0AAN6PFC5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">C8A01DRAFT_46683</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854389">
        <property type="protein sequence ID" value="KAK4039866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PFC5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015149">
        <property type="term" value="F:hexose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05259">
        <property type="entry name" value="PCBER_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045263">
        <property type="entry name" value="GLUT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045312">
        <property type="entry name" value="PCBER-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503:SF8">
        <property type="entry name" value="FACILITATED GLUCOSE TRANSPORTER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="440"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="467"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="585"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="615"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="650"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="675"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="715"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="746"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="275"/>
            <end position="771"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK4039866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="787" mass="84257" checksum="E30927BDF2EBD726" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PG45</accession>
    <name>A0AAN6PG45_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_36673</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854402">
        <property type="protein sequence ID" value="KAK4039375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PG45"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042830721" evidence="2">
        <location>
            <begin position="22"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="194"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4039375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="253" mass="26751" checksum="82CD49A2D9516436" modified="2024-10-02" version="1">MHTTFGHFLVAGVMAASAVSSFSFAPAGSDMARLVAPVLALAVPAYGLPAIQARAPHHQGAKAKGNGRNGARDVTEEEDEEDDDEAELESRAPHHQGAKAQGTGRKNGARDVEIREPHHQGAKAQGTGRKNGARDLDTREPHHQGAKAQGTSKKNGGRDVEARVPHHQGAKAQGTGRKNGARDLETREPHHQGAKAQGKGNNKGARALEELETREPHHQGAKAQGTGRKNGARDVEAREPHHQGAKGKGKTTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PGU1</accession>
    <name>A0AAN6PGU1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerases I, II, and III subunit RPABC5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_36145</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854390">
        <property type="protein sequence ID" value="KAK4039838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PGU1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006360">
        <property type="term" value="P:transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000024">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00250">
        <property type="entry name" value="RNApol_arch_Rpo10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023580">
        <property type="entry name" value="RNA_pol_su_RPB10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020789">
        <property type="entry name" value="RNA_pol_suN_Zn-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000268">
        <property type="entry name" value="RPABC5/Rpb10"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003089">
        <property type="entry name" value="PRK04016.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23431:SF3">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23431">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01194">
        <property type="entry name" value="RNA_pol_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005653">
        <property type="entry name" value="RNA_pol_N/8_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46924">
        <property type="entry name" value="RNA polymerase subunit RPB10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01112">
        <property type="entry name" value="RNA_POL_N_8KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4039838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="81" mass="9442" checksum="932178BA48E40A77" modified="2024-10-02" version="1">MIIPIRCFSCGKVTGDLWEKFVKLIEEEGLTDGDALDQLGCKRYCCRRMVMTHVDLIEKLLKYTPDGRNFKKIEMQQANQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PH45</accession>
    <name>A0AAN6PH45_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">D-lactate dehydrogenase (cytochrome)</fullName>
            <ecNumber evidence="6">1.1.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_15282</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(R)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13521"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding oxidoreductase/transferase type 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.4" evidence="6"/>
    <dbReference type="EMBL" id="MU854367">
        <property type="protein sequence ID" value="KAK4040899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PH45"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004458">
        <property type="term" value="F:D-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2190:FF:000001">
        <property type="entry name" value="D-2-hydroxyglutarate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2740:FF:000002">
        <property type="entry name" value="D-2-hydroxyglutarate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.43.10:FF:000002">
        <property type="entry name" value="D-2-hydroxyglutarate dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000001">
        <property type="entry name" value="D-2-hydroxyglutarate dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.45.10:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="entry name" value="Vanillyl-alcohol Oxidase, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-bd_oxidored_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051264">
        <property type="entry name" value="FAD-oxidored/transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43716">
        <property type="entry name" value="D-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43716:SF1">
        <property type="entry name" value="D-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="9">
        <location>
            <begin position="120"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="34"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="34"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00051436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4040899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="552" mass="60731" checksum="7A80FF38B78CDFD1" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PHI3</accession>
    <name>A0AAN6PHI3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">NBP35</name>
        <name evidence="12" type="ORF">C8A01DRAFT_15420</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NBP35-CFD1 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854370">
        <property type="protein sequence ID" value="KAK4040752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PHI3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904564">
        <property type="term" value="C:cytosolic [4Fe-4S] assembly scaffold complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02037">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000427">
        <property type="entry name" value="Cytosolic Fe-S cluster assembly factor NUBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03038">
        <property type="entry name" value="NUBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000808">
        <property type="entry name" value="Mrp-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028601">
        <property type="entry name" value="NUBP1/Nbp35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264:SF35">
        <property type="entry name" value="CYTOSOLIC FE-S CLUSTER ASSEMBLY FACTOR NUBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264">
        <property type="entry name" value="NUCLEOTIDE-BINDING PROTEIN NBP35 YEAST -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01215">
        <property type="entry name" value="MRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 10" id="KW-0408">Iron</keyword>
    <keyword evidence="9 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="86"/>
            <end position="93"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>ligand shared with heterodimeric partner</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>ligand shared with heterodimeric partner</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK4040752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="342" mass="36068" checksum="446E20A9D8F35731" modified="2024-10-02" version="1">MAPSLEAPEPVEDVLANPLKQKPQLVAPEPEHCPGPESQQAGTADSCAGCPNQAICASAPKGPDPDLPLITARLAGVKHKILVLSGKGGVGKSTLTSQLAQALATNPDTTVGVMDTDICGPSIPKMLGVEAETIHVSSSGWSPVWAADNLAVMSIQFMLPNRDDAIIWRGPKKNGLIKQFLKDVEWGELDFLLVDTPPGTSDEHLSVNTFLKESRIEGAVVVTTPQEVSLLDVRKEIDFCRKAGIRILGLVENMSLFVCPKCTHATEIFQATTGGGRALADEMGIPFLGAVPLDPRLGMACDFGESFFDSFPDSPACVALKGVVRGLAGQMGLDPDEVVPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PI17</accession>
    <name>A0AAN6PI17_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 15">Chromatin-remodeling ATPase INO80</fullName>
            <ecNumber evidence="15">3.6.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">C8A01DRAFT_34674</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Component of the INO80 chromatin-remodeling complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="15">The DBINO region is involved in binding to DNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="15"/>
    <dbReference type="EMBL" id="MU854360">
        <property type="protein sequence ID" value="KAK4041261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060255">
        <property type="term" value="P:regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18002">
        <property type="entry name" value="DEXQc_INO80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000006">
        <property type="entry name" value="Putative DNA helicase INO80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001269">
        <property type="entry name" value="SNF2 family helicase/ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020838">
        <property type="entry name" value="DBINO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031047">
        <property type="entry name" value="DEXQc_INO80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050520">
        <property type="entry name" value="INO80/SWR1_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45685:SF2">
        <property type="entry name" value="CHROMATIN-REMODELING ATPASE INO80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45685">
        <property type="entry name" value="HELICASE SRCAP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13892">
        <property type="entry name" value="DBINO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51413">
        <property type="entry name" value="DBINO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0010">Activator</keyword>
    <keyword evidence="7 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="13 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10 15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="DBINO" evidence="20">
        <location>
            <begin position="687"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="18">
        <location>
            <begin position="936"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="19">
        <location>
            <begin position="1508"/>
            <end position="1658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="430"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="491"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="813"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1737"/>
            <end position="1784"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="757"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="82"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="146"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="169"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="179"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="258"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="278"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="299"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="329"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="513"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="528"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="588"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="601"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="643"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="813"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1737"/>
            <end position="1749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="1769"/>
            <end position="1783"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU368001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAK4041261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1795" mass="201893" checksum="917CD5E5BE36D18D" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PIB6</accession>
    <name>A0AAN6PIB6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Cystathionine beta-lyase</fullName>
            <ecNumber evidence="4">4.4.1.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Cysteine-S-conjugate beta-lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">C8A01DRAFT_45626</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L,L-cystathionine + H2O = L-homocysteine + pyruvate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13965"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:58161"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>an S-substituted L-cysteine + H2O = a thiol + pyruvate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:18121"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29256"/>
            <dbReference type="ChEBI" id="CHEBI:58717"/>
            <dbReference type="EC" id="4.4.1.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="12">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homocysteine from L-cystathionine: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.13" evidence="4"/>
    <dbReference type="EMBL" id="MU854362">
        <property type="protein sequence ID" value="KAK4041187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PIB6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047804">
        <property type="term" value="F:cysteine-S-conjugate beta-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140567">
        <property type="term" value="F:membrane protein dislocase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071266">
        <property type="term" value="P:'de novo' L-methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000538">
        <property type="entry name" value="ATPase family AAA domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000013">
        <property type="entry name" value="Cystathionine beta-lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000009">
        <property type="entry name" value="Cystathionine gamma-synthase homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006238">
        <property type="entry name" value="Cys_b_lyase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054542">
        <property type="entry name" value="Cys_met_metab_PP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01329">
        <property type="entry name" value="cysta_beta_ly_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808:SF50">
        <property type="entry name" value="CYSTATHIONINE BETA-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="TRANS-SULFURATION ENZYME FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="18">
        <location>
            <begin position="131"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="360"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="394"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00046315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00072331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAK4041187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="854" mass="92888" checksum="D5DE6D0776B21F14" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PIM1</accession>
    <name>A0AAN6PIM1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_16749</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854406">
        <property type="protein sequence ID" value="KAK4039250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PIM1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049680">
        <property type="entry name" value="FLVCR1-2_SLC49-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10924">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10924:SF6">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 49 MEMBER A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="53"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4039250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="308" mass="32843" checksum="92377A52F736EC85" modified="2024-10-02" version="1" fragment="single">MARDSADEKECGQTATHEQKSRDSDSARPSVSEIEEVGSGAMGGQSRPWQALRGEEADHVEKTATRSTSGSGGNGNGVGSSVEAAKRGTMDEMAIEMDTVTTHATGSEPGSSARAGRDGATVEAAAGGIEYKVYKRRWFGLLQLTLLNVIVSWDWLTFSPVASHAARYFNTTETVVNWLSTAFLFAFSFITPVVIYVLHLGPKKSIVTAAALLLVGNWIRYAGSHSSSGGIFGVVMFGQILNGLAQPFVLAAPARYSDLWFTNRGRVAATALMSLANPFGAALGQLVIPFWVNQPSDVSNMVLYVSII</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PJ17</accession>
    <name>A0AAN6PJ17_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AN1-type zinc finger protein TMC1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_14537</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854351">
        <property type="protein sequence ID" value="KAK4041786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PJ17"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1110.10">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035896">
        <property type="entry name" value="AN1-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000058">
        <property type="entry name" value="Znf_AN1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01428">
        <property type="entry name" value="zf-AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00154">
        <property type="entry name" value="ZnF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118310">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51039">
        <property type="entry name" value="ZF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="AN1-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4041786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="101" mass="11230" checksum="8E61540FB45D67F3" modified="2024-10-02" version="1">MPKVKCSFETCRLPAQRIVGDCSFCEGSFCKHHRLLEDHDCQNLEDVSSGYPAPSQWWLVGLAGVLPEDTLADLLSQCKKALHAANAMQLNKERTQVIKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PJC3</accession>
    <name>A0AAN6PJC3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_46438</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854382">
        <property type="protein sequence ID" value="KAK4040201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PJC3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4040201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="182" mass="20099" checksum="227E33AA5D8A26A3" modified="2024-10-02" version="1">MCHGHPHYHSCGHQSVAWHYCPSALIDLETGYETPCPNITFAASQSSTAACPLANCDFRSAGGGGWTCCKCGGRNSSGWCKNMSPEPKWEKNPLTDEWEWMERCDHGCCRSCIKDPQASSGETIRKEGRKGKESRRHRQHASAISFEADPVASYNIELNYSGKNASGSRNDKSSRSASHRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PJP7</accession>
    <name>A0AAN6PJP7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_14882</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854359">
        <property type="protein sequence ID" value="KAK4041338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PJP7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4041338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="105" mass="11102" checksum="70235B9B5BF7A0A7" modified="2024-10-02" version="1" fragment="single">PQATTAAEPSQVDGGPQKERRYGPTDEQLARAHEILARLEAEGVIKPFVVRYPSLILDDGTVLDLNQPGPAKTSSEGACENSDGALVSSAEADCPSRGEKKTARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PJT6</accession>
    <name>A0AAN6PJT6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_33856</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854346">
        <property type="protein sequence ID" value="KAK4042092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PJT6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13156">
        <property type="entry name" value="KOW_RPL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000014">
        <property type="entry name" value="60S ribosomal protein L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000915">
        <property type="entry name" value="60S_ribosomal_eL6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049633">
        <property type="entry name" value="Ribosomal_eL6_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041997">
        <property type="entry name" value="Ribosomal_eL6_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10715">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10715:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01159">
        <property type="entry name" value="Ribosomal_L6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01170">
        <property type="entry name" value="RIBOSOMAL_L6E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4042092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="200" mass="22239" checksum="7DD11ECA3D7D084F" modified="2024-10-02" version="1">MSASTTTKAFGKSTRSVPHPTEKASKWYPAEDEAKPRKVRKAIRAWAPRTSLQPGTVLILLAGRFRGKRVVLLKNLDQGVLLVTGPFKINGVPLRRVNSRYVIATSLKVDLAGIDSAKIEEISRPKYFTAEKTKEKAGEEAFFKQGEKPQKKEVSSSRAADQKAIDKALLANIKKVDMLASYLATSFSLRKGDKPHEMKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PL08</accession>
    <name>A0AAN6PL08_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_15688</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854377">
        <property type="protein sequence ID" value="KAK4040450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PL08"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4040450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="413" mass="46152" checksum="37A6E87F0FE17B12" modified="2024-10-02" version="1">MGPTSYPPNLIEYVWPCGHHENVEVQPAPGIPFVRGQFSLPVAKPPEDFTEEERTGVPGRRKCCRCWATCSLFKPLEACEECDHPFTGCPTCMIVDSSGSREIATIEQRPIGEFDQTPEYWRCNACEHVNPFDGEGPINGFLAPKVSDYMDDMECKKCAGPFTEDNWVISPYWVYLGTWNGRVVAEGGPWHWSLEWHRDCADENHTKDDCYSTRKNGRRRRENPCINKNFASESAAKPLIPPILIVDTDHDHSLPPPSAGLTPFPEEHEEHAYGSDREMAPDFQQQASLHPDNQTIGTGGFTIGDYGSDDDEEAGERGLAVPEDDQEPDLGSYYDAPADDEPLLEDGEQPLDMEPPLEDGDYQDDQASLDEYYGEGEPALDDDYDAHPEEDLPAEAEPPPQDGKHDVYPSDAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PL51</accession>
    <name>A0AAN6PL51_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ribosomal protein L5 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_13395</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854332">
        <property type="protein sequence ID" value="KAK4043044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PL51"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002132">
        <property type="entry name" value="Ribosomal_uL5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031309">
        <property type="entry name" value="Ribosomal_uL5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_uL5_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031310">
        <property type="entry name" value="Ribosomal_uL5_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11994">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00281">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00673">
        <property type="entry name" value="Ribosomal_L5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="RL5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL5 N-terminal" evidence="5">
        <location>
            <begin position="189"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL5 C-terminal" evidence="6">
        <location>
            <begin position="247"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="144"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="146"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4043044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="351" mass="38561" checksum="191B7A24B4E09187" modified="2024-10-02" version="1">MASLRGLSRPARSLPLSPLSRQTYTAGSIRCASSQAADGSAPVIADLENSTLTTPQLGDAEKREFRPWKRAADRKVALPSGRYQYHPPKYNRGPLHPVQSPASSDPIARDFVPGPFNLPRLKQTYHSTIAPDLMTLAYTHVPPGTPKKEAAPRLRGWDGSSPYHKNRALRGPRGNPVLPLVERDITFNNVPAITEVTIASYVPAAIADPDHLLVARSVLLSLTGTTPEITKTSSNVVQWGIKIGDRAGVKTTIYGNAAYEFLDRCVHLVFPRIKDWKGIRATTGDSSGNLSFGMSPEEVKLFPEVEINYWMYPAKMVPGCRVFIKTSATSDRQARLLLQSFGVPFYGEVRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PLH2</accession>
    <name>A0AAN6PLH2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cyclin-dependent kinase</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">C8A01DRAFT_13197</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="MU854329">
        <property type="protein sequence ID" value="KAK4043248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PLH2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07843">
        <property type="entry name" value="STKc_CDC2L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000054">
        <property type="entry name" value="Cyclin-dependent kinase 11B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000211">
        <property type="entry name" value="Cyclin-dependent kinase G-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045267">
        <property type="entry name" value="CDK11/PITSLRE_STKc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF107">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 11A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="110"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="26"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="407"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK4043248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="473" mass="52170" checksum="66111967E9380656" modified="2024-10-02" version="1">MASKAKSRWADDEADAALEAQLKKEKEEKKRLKAEKARRLEAEKQAREAAAAAAQQEGDGANGPPAKRRKVSPERETAQAAGGSDGSANAPKLLRFDGGAFGKSRSVENYDKLNDIEEGAYGWVSRAKEAATGKVVALKRLKIDPKDRGGLPVTGLREIQILKDCDHRNVVKLREVVVGDDTSKIENIFLVLEFLEHDLKSILEDMPEPFLASEVKTLLQQLASGVAYLHDNWILHRDLKTSNLLLNNRGQLKIADFGMARYVGDPPPRQLTQLVVTLWYRAPELLLGAARYGASIDMWSVGCIFGELLTREPLLQGRNEVDELTKIFELCGVPTDESWPGFRRLPNARTLRLPPSSGGKTASGSVIRAKFPLLTAAGVGLLNGLLALDPDKRPTAKEMLAHEYFRQDPKPKQEAMFPTFPSKAGQERRRRRETPNAPARGQQAADFGAVDFSGIFAGREREERGGGFSLRMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PLQ4</accession>
    <name>A0AAN6PLQ4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_14876</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854358">
        <property type="protein sequence ID" value="KAK4041399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PLQ4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053235">
        <property type="entry name" value="Ser_Thr_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24361">
        <property type="entry name" value="MITOGEN-ACTIVATED KINASE KINASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4041399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="314" mass="34529" checksum="9E103DA0E04C550F" modified="2024-10-02" version="1">MRASTRTMFGLDLQHGQILQGRRASYGIAASLRNRQGGPWLATDSSGPHQERVTVKAAPAKRLENEARMPRLFQGCALIRQLVDEVDDPRSLVLKYMDDNVINLLKTKRPPRVEAKRALKATVQALVALHEKNVVHTDIKPDNIPVKHSPAGALYKLGDLGDSSSPDVASNDGGHLIGAELFCAPEVPLGIPWTVKADIWGLGATGITLITGHYVFLPRNAPPPGDPQLSLAVLQIQNDFYGPISRQALHGLADDSILPLLQQFEENHRPFTLSSASAVITQEDIDFFGYIMKIDPRQRPTANEILEHPWFKGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PMP6</accession>
    <name>A0AAN6PMP6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_32317</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854326">
        <property type="protein sequence ID" value="KAK4043587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PMP6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4043587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="480" mass="53646" checksum="1E2484401C786622" modified="2024-10-02" version="1">MPPKKAAGRGRGGRRGGAAESSRLRVRGRGPSPGRSVGAPSVYESSPELVAQPAPQPDPQPDPAPAAAALPPRAQPDPPIIRSGDASGAASGAANSTRRQQRGARATRAWDFTDVPLNLDQRGRNGRVAGRTLISWGRPRMAEKLLLHMQYEMVQAGLEIPFDRIAHRLRPGASGDERSVATSCRDPETDDLRSTRPVRYNEPFEDRLVGFPDAINLHANRRRQEHDGEGSEDGAEHEEALAVDQEARERAGNSIDRSRSRREGTPDAAELDLEAESRPHAQKRQRASRNAPRHASPEGQWDNLDNPENDNRQSGLFIDNESTYSAQANFRPTAKNTRVQRPILPARNQYFRQTEDREYYRANRQTCQTPAYHEYSSLLIYGTRIMNTTVKRLAAHRVILLRGSPTRRSLSIRPDKVTQWLLTEVVVGNFRKLNTTTKMWMLMHRVATRCMPNSAPGVTDGRNRTRMRLAVPRLGSLREM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PP29</accession>
    <name>A0AAN6PP29_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA wybutosine-synthesizing protein 4</fullName>
            <ecNumber evidence="5">2.1.1.290</ecNumber>
            <ecNumber evidence="4">2.3.1.231</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Leucine carboxyl methyltransferase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">tRNA(Phe) (7-(3-amino-3-(methoxycarbonyl)propyl)wyosine(37)-N)-methoxycarbonyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-O)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">C8A01DRAFT_12935</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. May methylate the carboxyl group of leucine residues to form alpha-leucine ester residues.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>7-[(3S)-(3-amino-3-methoxycarbonyl)propyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine + CO2 = wybutosine(37) in tRNA(Phe) + S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:37119"/>
            <dbReference type="Rhea" id="RHEA-COMP:11844"/>
            <dbReference type="Rhea" id="RHEA-COMP:11847"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73544"/>
            <dbReference type="ChEBI" id="CHEBI:74275"/>
            <dbReference type="EC" id="2.3.1.231"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine = 7-[(3S)-(3-amino-3-methoxycarbonyl)propyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:36903"/>
            <dbReference type="Rhea" id="RHEA-COMP:10379"/>
            <dbReference type="Rhea" id="RHEA-COMP:11844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73543"/>
            <dbReference type="ChEBI" id="CHEBI:74275"/>
            <dbReference type="EC" id="2.1.1.290"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">tRNA modification; wybutosine-tRNA(Phe) biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the methyltransferase superfamily. LCMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.290" evidence="5"/>
    <dbReference type="EC" id="2.3.1.231" evidence="4"/>
    <dbReference type="EMBL" id="MU854326">
        <property type="protein sequence ID" value="KAK4043620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PP29"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008175">
        <property type="term" value="F:tRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031591">
        <property type="term" value="P:wybutosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.650:FF:000043">
        <property type="entry name" value="tRNA wybutosine-synthesizing protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007213">
        <property type="entry name" value="Ppm1/Ppm2/Tcmp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46529">
        <property type="entry name" value="TRNA WYBUTOSINE-SYNTHESIZING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46529:SF1">
        <property type="entry name" value="TRNA WYBUTOSINE-SYNTHESIZING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13418">
        <property type="entry name" value="Beta-prop_TYW4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04072">
        <property type="entry name" value="LCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="JmjC" evidence="17">
        <location>
            <begin position="852"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAK4043620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1042" mass="113707" checksum="34F35DB42A247A70" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PPE7</accession>
    <name>A0AAN6PPE7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP phosphoribosyltransferase</fullName>
            <ecNumber evidence="5">2.4.2.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">C8A01DRAFT_42731</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + ATP</text>
            <dbReference type="Rhea" id="RHEA:18473"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:73183"/>
            <dbReference type="EC" id="2.4.2.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ATP phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.17" evidence="5"/>
    <dbReference type="EMBL" id="MU854318">
        <property type="protein sequence ID" value="KAK4044552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PPE7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003879">
        <property type="term" value="F:ATP phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.120:FF:000003">
        <property type="entry name" value="ATP phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000082">
        <property type="entry name" value="ATP phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000123">
        <property type="entry name" value="HIS1p ATP phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00079">
        <property type="entry name" value="HisG_Long"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020621">
        <property type="entry name" value="ATP-PRT_HisG_long"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013820">
        <property type="entry name" value="ATP_PRibTrfase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018198">
        <property type="entry name" value="ATP_PRibTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001348">
        <property type="entry name" value="ATP_PRibTrfase_HisG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013115">
        <property type="entry name" value="HisG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00070">
        <property type="entry name" value="hisG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03455">
        <property type="entry name" value="HisG_C-term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21403:SF8">
        <property type="entry name" value="ATP PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21403">
        <property type="entry name" value="ATP PHOSPHORIBOSYLTRANSFERASE ATP-PRTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01634">
        <property type="entry name" value="HisG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08029">
        <property type="entry name" value="HisG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="GlnB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01316">
        <property type="entry name" value="ATP_P_PHORIBOSYLTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP phosphoribosyltransferase catalytic" evidence="14">
        <location>
            <begin position="59"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine biosynthesis HisG C-terminal" evidence="15">
        <location>
            <begin position="257"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK4044552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="333" mass="35728" checksum="0A502396E7D1E473" modified="2024-10-02" version="1">MDLVNHLEGRLLFAVPKKGRLLQAALNLLEGADIQFRRENRLDIALVKNLPIALVFLPAADIPTFVGEGRVDLGITGHDQVQEHDAGTRALARARRMSNEWDPARAAAGKPQGCETVLDLGFGACRLQVQVPAKGEYATGKDLIGKNVGTSFVHLAREYFARLELEQEGITDPVQMDARKLRTKIIELSGSVEAACALGVADGIVDLVESGETMKAAGLKAIDTVVETSAILIKSKAPSNPALVDLIASRIRGVITAQKYVLCQYNVPRAKLADATGITPGKRAATVTSLDEEGWVAVSAMVEKKRIATVMDDLVHVGATDILVLDIHNTRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PPQ5</accession>
    <name>A0AAN6PPQ5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_14020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854342">
        <property type="protein sequence ID" value="KAK4042355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PPQ5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4042355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="112" mass="12424" checksum="FFFA09CF08A2F68D" modified="2024-10-02" version="1" fragment="single">DTRRKILDFVDKTEPFQNRPDPDLPPGYTSHLRRLFRLIDGHGSKGMVEQAAQTAVFPRGSLPTAFNIGLVYVTMALYCAARLTLVAVGLSSLRAMPQGVYKTTWADYIPAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PPT9</accession>
    <name>A0AAN6PPT9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Chitin deacetylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">C8A01DRAFT_43171</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854322">
        <property type="protein sequence ID" value="KAK4044010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PPT9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10951">
        <property type="entry name" value="CE4_ClCDA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11618">
        <property type="entry name" value="ChtBD1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.10">
        <property type="entry name" value="Endochitinase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001002">
        <property type="entry name" value="Chitin-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036861">
        <property type="entry name" value="Endochitinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471">
        <property type="entry name" value="CHITIN DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471:SF2">
        <property type="entry name" value="CHITIN DEACETYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00270">
        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57016">
        <property type="entry name" value="Plant lectins/antimicrobial peptides"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50941">
        <property type="entry name" value="CHIT_BIND_I_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2 8" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="7" id="KW-0170">Cobalt</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042903068" description="Chitin deacetylase" evidence="10">
        <location>
            <begin position="18"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-1" evidence="11">
        <location>
            <begin position="72"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="12">
        <location>
            <begin position="150"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-1" evidence="11">
        <location>
            <begin position="407"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="40"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="370"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="457"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="82"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="87"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="410"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="424"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK4044010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="583" mass="60911" checksum="759453349EB5380A" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PQ82</accession>
    <name>A0AAN6PQ82_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutamine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">C8A01DRAFT_44031</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>tRNA(Gln) + L-glutamine + ATP = L-glutaminyl-tRNA(Gln) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20121"/>
            <dbReference type="Rhea" id="RHEA-COMP:9662"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.18" evidence="2"/>
    <dbReference type="EMBL" id="MU854333">
        <property type="protein sequence ID" value="KAK4042961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PQ82"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004819">
        <property type="term" value="F:glutamine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006425">
        <property type="term" value="P:glutaminyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.240.10:FF:000007">
        <property type="entry name" value="Glutamine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000037">
        <property type="entry name" value="Glutamine--tRNA ligase cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.240.10:FF:000015">
        <property type="entry name" value="Glutaminyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="entry name" value="Ribosomal Protein L25, Chain P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004514">
        <property type="entry name" value="Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050132">
        <property type="entry name" value="Gln/Glu-tRNA_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020059">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_codon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_bL25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_bL25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00440">
        <property type="entry name" value="glnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097:SF4">
        <property type="entry name" value="GLUTAMINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097">
        <property type="entry name" value="GLUTAMINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03950">
        <property type="entry name" value="tRNA-synt_1c_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="Ribosomal protein L25-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic" evidence="11">
        <location>
            <begin position="88"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic" evidence="11">
        <location>
            <begin position="319"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding" evidence="12">
        <location>
            <begin position="389"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="16"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK4042961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="614" mass="69675" checksum="C04C0C1A9DFB7710" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PQF0</accession>
    <name>A0AAN6PQF0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Cytochrome oxidase assembly protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">C8A01DRAFT_12340</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2</text>
            <dbReference type="Rhea" id="RHEA:63388"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:60530"/>
            <dbReference type="ChEBI" id="CHEBI:61715"/>
            <dbReference type="EC" id="1.17.99.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:63389"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="10">Porphyrin-containing compound metabolism; heme A biosynthesis; heme A from heme O: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854320">
        <property type="protein sequence ID" value="KAK4044310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PQF0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120547">
        <property type="term" value="F:heme A synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016653">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006784">
        <property type="term" value="P:heme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01665">
        <property type="entry name" value="HemeA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003780">
        <property type="entry name" value="COX15/CtaA_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023754">
        <property type="entry name" value="HemeA_Synthase_type2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23289">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23289:SF2">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02628">
        <property type="entry name" value="COX15-CtaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="249"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="304"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="415"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="440"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="47"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK4044310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="499" mass="54772" checksum="CF78A740742E0707" modified="2024-10-02" version="1">MAFFQLGLRRAAAHLSRVPFACGPCVRQQVPAPPSRVLQLARAARSYASTPTPESKTPIESLSSNTAKAARPAAQSSSSQNSRKSSSFPETNAKVVGYWLVGSAVSVFGIVVFGGLTRLTESGLSITEWRPVTGSLPPMSDADWQSEFDKYRASPEFKLINPHMDLAEFKKIYFMEWTHRIWGRVIGLTFVLPTIYFIARRRVTPRMAVNLVGISALIAFQGFIGWWMVKSGLKDDLFAPGSHPRVSQYRLTAHLATAFVCYAWMLVSGLGVLRTHRLLRDPEATTKMFAALKSPTLRTLRRSIAGLTVLIFTTVLSGALVAGLDAGLIYNEFPMMGNGLTPPKSELFDKFYSRKEDGSDLWWRNMLENPSLVQLDHRILATTTFTAVVALFVYSRTGRIKAAMPRDVRKGVTGLLHLALLQVSLGITTLMYMVPISLAAAHQAGALALLTGALVTGHRLRASKATQALVQKALQSPSKLQTGAISQKLLKKIAENKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PQU9</accession>
    <name>A0AAN6PQU9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein SKT5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_42729</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854318">
        <property type="protein sequence ID" value="KAK4044550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PQU9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051726">
        <property type="entry name" value="Chitin_Synth_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430:SF1">
        <property type="entry name" value="CHITIN SYNTHASE REGULATOR SKT5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430">
        <property type="entry name" value="PROTEIN SKT5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="303"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="406"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="728"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="103"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="164"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="205"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="740"/>
            <end position="752"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4044550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="752" mass="81309" checksum="25C69B0E49FB6A36" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PR01</accession>
    <name>A0AAN6PR01_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SMODS and SLOG-associating 2TM effector domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_13092</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854328">
        <property type="protein sequence ID" value="KAK4043366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PR01"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041622">
        <property type="entry name" value="SLATT_fungi"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF033635">
        <property type="entry name" value="SLATT_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38793">
        <property type="entry name" value="SLATT_FUNGAL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38793:SF3">
        <property type="entry name" value="SMODS AND SLOG-ASSOCIATING 2TM EFFECTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18142">
        <property type="entry name" value="SLATT_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="SMODS and SLOG-associating 2TM effector" evidence="2">
        <location>
            <begin position="88"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4043366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="375" mass="41171" checksum="C2BF79B52FE9C626" modified="2024-10-02" version="1">MASFVKSLLRLASPKPKVRPDEEQATTADSVFGSSTLQPSHILTTGHRIPADDALALFRLTLGITSAPHLGFHLSAHRPADNVGLYARVVRAEQTAKDSYKVFSLVINACYFLQIIVAASLTALGAANADNKAITAFGAINTVIAGFLTYLKGSGYPARFKYCASEWKKVREFVEHRERDFSLEGCTLDVYQEVDAIRDMYEATKRDIEANNPEGYHSKTGGNNNNNNNLKIRYDGVDKAKADAIAGKLRGLDDKVRKLRGHVGSAANDVESKSDDVAAKLRSLEDTLEKVKTHMGKTSTVHHAIQDSREAAHSTIHHTMQDVEKRAMAELRNLGKAVVRGVEEHRPRPPREVSITVAHRDGDDHANEAEAAVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PR90</accession>
    <name>A0AAN6PR90_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Formamidopyrimidine-DNA glycosylase N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">C8A01DRAFT_43932</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of DNA containing ring-opened 7-methylguanine residues, releasing 2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimidine.</text>
            <dbReference type="EC" id="3.2.2.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854331">
        <property type="protein sequence ID" value="KAK4043150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PR90"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008534">
        <property type="term" value="F:oxidized purine nucleobase lesion DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08972">
        <property type="entry name" value="PF_Nei_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.50:FF:000009">
        <property type="entry name" value="Formamidopyrimidine-DNA glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.190.10">
        <property type="entry name" value="MutM-like, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012319">
        <property type="entry name" value="FPG_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035937">
        <property type="entry name" value="FPG_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015886">
        <property type="entry name" value="H2TH_FPG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_uS13-like_H2TH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22993">
        <property type="entry name" value="FORMAMIDOPYRIMIDINE-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22993:SF9">
        <property type="entry name" value="FORMAMIDOPYRIMIDINE-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01149">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06831">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00898">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01232">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81624">
        <property type="entry name" value="N-terminal domain of MutM-like DNA repair proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="S13-like H2TH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51068">
        <property type="entry name" value="FPG_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Formamidopyrimidine-DNA glycosylase catalytic" evidence="11">
        <location>
            <begin position="2"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="308"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="325"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="365"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK4043150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="392" mass="44005" checksum="F48688F19B23DE64" modified="2024-10-02" version="1">MPEIAEIARVVHYLRLHLVGKTIKKATAIEDTNVFGKVGTTGAEVAAALTGKKVLSAGTQGKYFWLVLDQPPHPVMHFGMTGWIHIKGDRTAYTNYYKKMKPEEMDAWPPKHWKFQLTTEDPAVEVAFTDPRRFGRVRLVDCPGESIRKYSPLVENGPDPVVDTDVFTEEYLRKKMQSRHVPIKALILDQTVISGVGNWVGDEVLYQAKLHPEQYCDDFSDEQIKKLYESIRHVCQFAVDKLGDSDLFPKEWLFQHRWSKGQKGAVGHLPSGEKLAFLTVGGRTSCYVPEVQKKSGRIVPGVKEELIESDQEEVKPKKAARSKAAKVEDEKPQNKKKRKAEEDEPPAKKSRAAPRKPPAGKTKAAKAEGPDTVDSKIESGRRRSGRLQGKTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PSN2</accession>
    <name>A0AAN6PSN2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Succinyl-CoA ligase subunit alpha, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_42755</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854318">
        <property type="protein sequence ID" value="KAK4044579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PSN2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009361">
        <property type="term" value="C:succinate-CoA ligase complex (ADP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004776">
        <property type="term" value="F:succinate-CoA ligase (GDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000001">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000340">
        <property type="entry name" value="Succinyl-CoA synthetase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11117">
        <property type="entry name" value="SUCCINYL-COA LIGASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11117:SF6">
        <property type="entry name" value="SYNTHETASE SUBUNIT ALPHA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G10830)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01798">
        <property type="entry name" value="SCOASYNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA-binding" evidence="2">
        <location>
            <begin position="135"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4044579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="788" mass="84065" checksum="0E03A0EB75562602" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SKA4</accession>
    <name>A0AAN6SKA4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_51441</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the ustYa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854785">
        <property type="protein sequence ID" value="KAK4031496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SKA4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF4">
        <property type="entry name" value="CYCLOCHLOROTINE BIOSYNTHESIS PROTEIN O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0843">Virulence</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4031496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="208" mass="23797" checksum="F90E1C3EDB43CEB8" modified="2024-10-02" version="1">MSEALPKEILEYEEKPEWRGLQHPWNLEPSEELDAVWEDLLYALNIRISEDEINILHENRTNRVKVNGGGYAGVLGVYHHMHCLNNLRRVVHWDFYGPTLATAKHAEGFSKEHSAEARLTGEPDHCIDAIRQALMCHANTALYTAEWMNDSHVPINKELRSGAVTTCVKWDSLDRWARKKALVPGHYQYLPGPYEVNRVEDGLSGRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SL11</accession>
    <name>A0AAN6SL11_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Alpha-amylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_21552</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU855001">
        <property type="protein sequence ID" value="KAK4031197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SL11"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11318">
        <property type="entry name" value="AmyAc_bac_fung_AmyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013776">
        <property type="entry name" value="A-amylase_thermo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015237">
        <property type="entry name" value="Alpha-amylase_C_pro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006968">
        <property type="entry name" value="PRK09441.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006969">
        <property type="entry name" value="PRK09441.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43447">
        <property type="entry name" value="ALPHA-AMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09154">
        <property type="entry name" value="Alpha-amy_C_pro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001021">
        <property type="entry name" value="Alph-amls_thrmst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="7">
        <location>
            <begin position="66"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4031197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="569" mass="63677" checksum="DFE7449B90C84215" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SM96</accession>
    <name>A0AAN6SM96_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tyrosinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_20571</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854621">
        <property type="protein sequence ID" value="KAK4032340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SM96"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF126">
        <property type="entry name" value="TYROSINASE-LIKE PROTEIN TYR-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="4">
        <location>
            <begin position="233"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4032340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="312" mass="34844" checksum="3B3DFDC4E061607C" modified="2024-10-02" version="1">MEEPGSGFRKVHVSSATNTNETQPAPSCRENVRVEWNNMADADKLKYVQSVKCLMNATPLGVWANATSIWDEITWVHEQLSERIHGVDTFLPWHRYYLHMLKTLLKDHCAYTGPMPWWRETDYTGDFAGSGLFTPEYFGALPPLSDTGEGTCITDGAFANTTVLVGPDGPTCLSRGETKQTTDEATTATLDLCHGNANTEYTQHRRCVEQTIHATMHEGIGPTMWLLATSPGDPIFFMHHGFVDWQWKRWQDVSRTRSTSISGCAEYPGDGSPCVPLSRDTVLTTMGLVPDMTVGDVLDTENTIICYTYDEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SME2</accession>
    <name>A0AAN6SME2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Ferric reductase NAD binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">C8A01DRAFT_40572</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854560">
        <property type="protein sequence ID" value="KAK4032984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SME2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043020">
        <property type="term" value="C:NADPH oxidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016175">
        <property type="term" value="F:superoxide-generating NAD(P)H oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042554">
        <property type="term" value="P:superoxide anion generation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000103">
        <property type="entry name" value="NADPH oxidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000004">
        <property type="entry name" value="NADPH oxidase isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000778">
        <property type="entry name" value="Cyt_b245_heavy_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050369">
        <property type="entry name" value="RBOH/FRE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972">
        <property type="entry name" value="NADPH OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972:SF153">
        <property type="entry name" value="SUPEROXIDE-GENERATING NADPH OXIDASE HEAVY CHAIN SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00466">
        <property type="entry name" value="GP91PHOX"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01169">
        <property type="entry name" value="NADPH_oxidase_subgroup_(NOX)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="182"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="12">
        <location>
            <begin position="289"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK4032984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="583" mass="66795" checksum="006E3424DE424FEA" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SMU3</accession>
    <name>A0AAN6SMU3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_40066</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854528">
        <property type="protein sequence ID" value="KAK4033464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SMU3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4033464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="61" mass="7129" checksum="43D02AE6C2F52577" modified="2024-10-02" version="1">MCIQYYREYTCGCKRQEEFVQCDKRLGSNVRCDPVRPVPLPGALHMCVRHMVQEGKDEMHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SN09</accession>
    <name>A0AAN6SN09_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_19413</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854516">
        <property type="protein sequence ID" value="KAK4033674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SN09"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4033674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="299" mass="31677" checksum="B9B9D78650AB119B" modified="2024-10-02" version="1">MDDQAKLNKTTSAPPQASAQVPSPDSSQEDLPGSKHQSAASTTLPSPRHAFPPIMNAYGQWTKLKSFNLCGATEKDRLYQVSLHTGYSASAPLGTRPGVLLHNGMSSKDPVLAAAGYDSQASFYSFNNQSVVLMPPLPGAAARAGDFVTEQMPAVIRGGLLVFPFSVELDSGGKIQHEKFEWRKFKSGVDGSAKEGGFRLVRLPSSGSTRLGGEPDTVASSSPAGGDDSEVVACLAWCKLFPTFKHAFTLQLLGRGQSGELGERWSLMVVITALRLWALRANHKTSKSAIAGGQKTAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SN13</accession>
    <name>A0AAN6SN13_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Soluble quino protein glucose/sorbosone dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_40271</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854541">
        <property type="protein sequence ID" value="KAK4033268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SN13"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054539">
        <property type="entry name" value="Beta-prop_PDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH_b-prop"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22807">
        <property type="entry name" value="TrAA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="Soluble quinoprotein glucose dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043019833" evidence="1">
        <location>
            <begin position="21"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="Pyrroloquinoline quinone-dependent pyranose dehydrogenase beta-propeller" evidence="2">
        <location>
            <begin position="42"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4033268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="435" mass="46378" checksum="7C0654EAB93109C6" modified="2024-10-02" version="1">MRLFETAVAVAALFFAGAEAQVPQLPRPKSCSGVSNFRYQYTAASGWSAMKIAGGLKQVRTIVWDPAGNMLVAQATKGISVHTFGADGCINSTSMLISGNQLNHGLALTPDGKTMYASGETAAYSWSYDSTTRTISNQKTVVKGISTGIHSTRTIAVVPSQPNLILVQVGSNANFDTAAAQKETGRAIIKIFDTSKAPANGFNYNTDGEVFGYGLRNTIGFVPDPSGVFWGVENSGDDFRRNNQDIHQNNPAEELNNLGNPLTTRNAWYGYPTCFAVWDPSSFGGSLKTGNNFVVSPTSSYNDATCNTNKAIPPRLSFQAHSAPIWNTFDADAKNMYVAMHGSWDRSPPTGFKIISIAFQKLADGSYDPVAAPDSQTGYEDVFGAPNPGSCTANGLTQSNCFRLTAAAWDPAGRGLFVGSDNSAEGEIFVLSQTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SN74</accession>
    <name>A0AAN6SN74_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Rhomboid-type serine protease</fullName>
            <ecNumber evidence="10">3.4.21.105</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">C8A01DRAFT_19710</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Serine protease involved in intramembrane proteolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains.</text>
            <dbReference type="EC" id="3.4.21.105"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Membrane</location>
            <topology evidence="2 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the peptidase S54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.105" evidence="10"/>
    <dbReference type="EMBL" id="MU854537">
        <property type="protein sequence ID" value="KAK4033330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SN74"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002610">
        <property type="entry name" value="Peptidase_S54_rhomboid-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22936:SF69">
        <property type="entry name" value="RHOMBOID-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22936">
        <property type="entry name" value="RHOMBOID-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="293"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="327"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="354"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="389"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="478"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="12">
        <location>
            <begin position="291"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="54"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="78"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK4033330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="531" mass="58098" checksum="5ED79E63602BAFE7" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SND6</accession>
    <name>A0AAN6SND6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">beta-fructofuranosidase</fullName>
            <ecNumber evidence="2">3.2.1.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_49906</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glycosyl hydrolase 32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.26" evidence="2"/>
    <dbReference type="EMBL" id="MU854524">
        <property type="protein sequence ID" value="KAK4033525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SND6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004564">
        <property type="term" value="F:beta-fructofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08996">
        <property type="entry name" value="GH32_FFase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.560">
        <property type="entry name" value="Exo-inulinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051214">
        <property type="entry name" value="GH32_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001362">
        <property type="entry name" value="Glyco_hydro_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013189">
        <property type="entry name" value="Glyco_hydro_32_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013148">
        <property type="entry name" value="Glyco_hydro_32_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43101">
        <property type="entry name" value="BETA-FRUCTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43101:SF1">
        <property type="entry name" value="BETA-FRUCTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08244">
        <property type="entry name" value="Glyco_hydro_32C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00251">
        <property type="entry name" value="Glyco_hydro_32N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00640">
        <property type="entry name" value="Glyco_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043002031" description="beta-fructofuranosidase" evidence="7">
        <location>
            <begin position="23"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 32 N-terminal" evidence="8">
        <location>
            <begin position="229"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 32 C-terminal" evidence="9">
        <location>
            <begin position="552"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4033525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="684" mass="74335" checksum="FC3B63D5C8FED613" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SNP5</accession>
    <name>A0AAN6SNP5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_18802</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854482">
        <property type="protein sequence ID" value="KAK4034364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SNP5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF160">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="312"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="396"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="425"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="463"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="491"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="60"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4034364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="541" mass="59840" checksum="64F14699C24C55CC" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SP17</accession>
    <name>A0AAN6SP17_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Metal-dependent HD superfamily phosphohydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_18477</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854466">
        <property type="protein sequence ID" value="KAK4034769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SP17"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009218">
        <property type="entry name" value="HD_phosphohydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21174">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21174:SF0">
        <property type="entry name" value="HD PHOSPHOHYDROLASE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF035170">
        <property type="entry name" value="HD_phosphohydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4034769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="198" mass="22379" checksum="28861B9492292B57" modified="2024-10-02" version="1">MTLITPASREELVALYSSPTRHYHSLNHVTALLALLSTHRQHFVDPDAVEAAIWFHDAIYDARAKGPCNELQSANLAVSRLSGTAEPKRVAWIREVIEATATHKLPEGLDGPEEADAALFLDMDLSILGAGETEFDEYEAAVRKEYDFVSDEAWRTGRAAVLKTFLERERVYHSELFRGLYEEVARRNLRRSLERLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SPT5</accession>
    <name>A0AAN6SPT5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_18129</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854453">
        <property type="protein sequence ID" value="KAK4035158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SPT5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039136">
        <property type="entry name" value="NUFIP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019496">
        <property type="entry name" value="NUFIP1_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13309:SF0">
        <property type="entry name" value="FMR1-INTERACTING PROTEIN NUFIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13309">
        <property type="entry name" value="NUCLEAR FRAGILE X MENTAL RETARDATION PROTEIN INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10453">
        <property type="entry name" value="NUFIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="470"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="470"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="548"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="104"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="179"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="247"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="264"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="292"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="332"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="367"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="403"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4035158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="613" mass="65710" checksum="1684A03108A4A405" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SPV1</accession>
    <name>A0AAN6SPV1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">26S proteasome regulatory subunit 6A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">C8A01DRAFT_48632</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854454">
        <property type="protein sequence ID" value="KAK4035130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000009">
        <property type="entry name" value="26S protease regulatory subunit 6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000076">
        <property type="entry name" value="26S protease regulatory subunit 6A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="26S protease regulatory subunit 6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 14" id="KW-0647">Proteasome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="242"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="10"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK4035130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="462" mass="51313" checksum="10DB90FF990AF6EE" modified="2024-10-02" version="1">MSTLEELDDLDRRERDEKDKKEKKGDDKGNQGSGNGDAEMKDAEPEEEDVLDPEILSLSTDDIKTRRRLLENDARIMKSEFQRLSHEKATMAEKIKENMEKIANNRQLPYLVGNVVELLDLDPTAESSEEGANIDLDATRVGKSAVIKTSTRQTIFLPLIGLVDPTKLRPADLIGVNKDSYLILDTLPAEYDSRVKAMEVDEKPTEKYTDVGGLTKQIAELLEAIVMPMKEADRFKKIGIKAPKGALMYGPPGTGKTLLARACAAQTDATFLKLAGPQLVQMFIGDGAKLVRDCFALAKEKAPAIIFIDELDAVGTKRFDSEKSGDREVQRTMLELLNQLDGFASDDRIKVIAATNRVDVLDPALLRSGRLDRKIEFPLPNEEARAQILKIHSRKMKVDEAINWDELARSTDEFGGAMLKAVCVEAGMIALRLGKNKIGHEHYVDAIAEVQAKKKDTVNFYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SPX1</accession>
    <name>A0AAN6SPX1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_48523</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854450">
        <property type="protein sequence ID" value="KAK4035263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SPX1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050889">
        <property type="entry name" value="Dendritic_Spine_Reg/Scaffold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24166:SF48">
        <property type="entry name" value="PROTEIN VAPYRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24166">
        <property type="entry name" value="ROLLING PEBBLES, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="453"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="142"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="46"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4035263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="516" mass="56336" checksum="B11CA5594BDE7801" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SQ29</accession>
    <name>A0AAN6SQ29_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_37943</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854439">
        <property type="protein sequence ID" value="KAK4038105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SQ29"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051229">
        <property type="entry name" value="ALYREF_mRNA_export"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025715">
        <property type="entry name" value="FoP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965">
        <property type="entry name" value="RNA AND EXPORT FACTOR BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965:SF35">
        <property type="entry name" value="RNA ANNEALING PROTEIN YRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01218">
        <property type="entry name" value="FoP_duplication"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="70"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="170"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="29"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="171"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4038105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="252" mass="26101" checksum="411D36B2A936FD90" modified="2024-10-02" version="1">MSGKLDQSLDEILTSQRRNQQGRRRSTRRTAGTTRPAPAAPAGGIQKNTKAARGANKPTPAKGAGLTGESKIMVSNLPRDVSEAQIKDYFQQSVGQVKKVEINYGPGGVSRGIAHVLFHHADGASKAFTTLNGLLIDNKPVKVEVVVASADLIPQPKSLAQRIAQPKVQPKSAATVKKNANATAGKGGAAAGRGGKKTTRGGRSNRPVKKTAEELDSEMADYFDGAAAENNTNAGAPAAAAGGDAAMEEDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SQS2</accession>
    <name>A0AAN6SQS2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DUF423 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_17301</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854423">
        <property type="protein sequence ID" value="KAK4038633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SQS2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006696">
        <property type="entry name" value="DUF423"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43461">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43461:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04241">
        <property type="entry name" value="DUF423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4038633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="148" mass="15561" checksum="C30116CFCB428687" modified="2024-10-02" version="1">MATDETSPLLPTPELDSSIDNDNTMSSTLLWKTGAVFGATAVGLGAFGAHGLKKSISDPHKLANWSTAAQYQLVHSVALLVASNNPVAGALFTAGMTMFSGSLYALTLDTERFRFMGPVTPLGGLCLIAGWLALAFGKRGAGTRWPRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SQU8</accession>
    <name>A0AAN6SQU8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7025 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_37152</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854416">
        <property type="protein sequence ID" value="KAK4038900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SQU8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054289">
        <property type="entry name" value="DUF7025"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411:SF3">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411">
        <property type="entry name" value="FAMILY ATPASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22942">
        <property type="entry name" value="DUF7025"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7025" evidence="2">
        <location>
            <begin position="44"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4038900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="321" mass="36061" checksum="B7207CD020BCBE7D" modified="2024-10-02" version="1">MLEIQDPLLVALAEVLKKQDVHLGVCENATFKHHVLELYSSYDDMKVLRYDGTQFLWEGYSVNINGFAGHRPVAGLPSYPLEFHEAAADVWVRLMARGRNVLGYQGLVYVNYSGVAIHVDEPLLMFMLLLVEGYALKNKLSVSFLVEDIAKVAWNDEAYDHLVYNEALQDVIVEKGLGHAAQWAARYVQDAVILLDEADVFMVERHLQDIARNDLVSIVLRELEYLRGIIFLTANLYSIIDSAFRSRVSLHLLFAALTLEARVLIWRKFLDRLPPSPQTAPSPPDERPAAVETKEGDPAAADSEANGGALSEWEIEELAAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SQW5</accession>
    <name>A0AAN6SQW5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_16720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854405">
        <property type="protein sequence ID" value="KAK4039277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SQW5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042951198" evidence="1">
        <location>
            <begin position="17"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4039277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="278" mass="28477" checksum="0D1B04BD6EFFA0ED" modified="2024-10-02" version="1">MKTTLPALALVALSSASHVSIEERQNSGVGTGPFAPAGYYTSNALGGHTFYAPKTVPAGTKLPVMLWGNGGCSADATGQAPFLTQLASQGVLVIASGTPRGGGSTTADVMKQSIDFITANAGKEGGAFANVDASRITAAGWSCGGVEAYAQIWDARVQSVGIWSSGLLTNYTAAQNFRKPVFFFLGGQSDIAYGNGERDYAAMPAGVPKWKGNLNVGHGGTYTDVNGGKFGVIGGHWVQWTMRGNASAAAYLTGSGAKNDGWSVVSADLDKLSVTPIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SQZ6</accession>
    <name>A0AAN6SQZ6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_36151</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854390">
        <property type="protein sequence ID" value="KAK4039844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SQZ6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042827373" evidence="1">
        <location>
            <begin position="22"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4039844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="59" mass="6167" checksum="678AF0FF490E5FE1" modified="2024-10-02" version="1">MRLNLSTAAAILSLAGTLVTATPIACSEWKRDLILKGELAPEACCSYGRCLGDVVVAMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SRD4</accession>
    <name>A0AAN6SRD4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Eukaryotic translation initiation factor 2 subunit gamma</fullName>
            <ecNumber evidence="2">3.6.5.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">C8A01DRAFT_16715</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.3" evidence="2"/>
    <dbReference type="EMBL" id="MU854405">
        <property type="protein sequence ID" value="KAK4039263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SRD4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005850">
        <property type="term" value="C:eukaryotic translation initiation factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01888">
        <property type="entry name" value="eIF2_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03688">
        <property type="entry name" value="eIF2_gamma_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15490">
        <property type="entry name" value="eIF2_gamma_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000009">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000011">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000065">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050543">
        <property type="entry name" value="eIF2G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015256">
        <property type="entry name" value="eIF2g_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044127">
        <property type="entry name" value="eIF2g_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044128">
        <property type="entry name" value="eIF2g_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003077">
        <property type="entry name" value="PRK04000.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42854">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42854:SF3">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09173">
        <property type="entry name" value="eIF2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="11">
        <location>
            <begin position="82"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="24"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="47"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00074422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK4039263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="512" mass="55470" checksum="3F37FDFC22DFAB3A" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SRT1</accession>
    <name>A0AAN6SRT1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SRPBCC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_46859</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854393">
        <property type="protein sequence ID" value="KAK4039756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SRT1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07822">
        <property type="entry name" value="SRPBCC_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36166">
        <property type="entry name" value="CHROMOSOME 9, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36166:SF1">
        <property type="entry name" value="SRPBCC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4039756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="148" mass="16594" checksum="878E492D8420F15B" modified="2024-10-02" version="1">MVHISAEIEINRSPDEVRAVLLDFNHWSAWLTTGLAITSPKSKPGLELKPGDRLHSDFRGTVVKPKVLTNTPATFEWRGRFMGVLLIGQRRFFFKKSEKTPGGTTLVQNEDIKGALAFLFKKNEGQGKIAREAMAQFNQEIKARAEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SRX2</accession>
    <name>A0AAN6SRX2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">tRNA-dihydrouridine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">C8A01DRAFT_46542</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Specifically modifies U47 in cytoplasmic tRNAs. Catalyzes the synthesis of dihydrouridine in some mRNAs, thereby affecting their translation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 5,6-dihydrouridine in mRNA + NAD(+) = a uridine in mRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69851"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="8">
            <dbReference type="Rhea" id="RHEA:69853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 5,6-dihydrouridine in mRNA + NADP(+) = a uridine in mRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69855"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="9">
            <dbReference type="Rhea" id="RHEA:69857"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854385">
        <property type="protein sequence ID" value="KAK4040055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SRX2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082">
        <property type="entry name" value="TRNA-DIHYDROURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082:SF31">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(20A_20B) SYNTHASE [NAD(P)+]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DUS-like FMN-binding" evidence="11">
        <location>
            <begin position="29"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="254"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00045934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK4040055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="378" mass="41730" checksum="F7AD43E5AC441A68" modified="2024-10-02" version="1">MAEMPDLELIHPLKLFDIAKNEKRFLYTCAPMVRYSKLAFRQTVYAYGTDLCWTPMILAKEFNRNRFARDSDFTISTNGPQPPTIVQFGANVPQELARASSLVAPFSNGVDLNCGCPQSWACSDTLGAALMEKRELVRDMVVETREQLRRDGWGVDKEKDIDNPKGRSVSVKIRVHKDLRKTIDFITTVLGPDQDRHIDWLTIHPRTRSTPSSTPINLEALEILTSTFGDRVPLLLSGDVFALNALPFTSPLLTTTPTFTTSSTPPPPTAATSNPLSHIPNLAGLMSARALLANPALYAGHDACPWPAVETFLSNVARCPLPFKLVQHHLSEMCGPGMGPNKSALLTKQQRARVMGCGNMVDLVDFLDGNVWSDRATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SS39</accession>
    <name>A0AAN6SS39_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nonsense-mediated mRNA decay factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_34918</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a role in nonsense-mediated mRNA decay.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854364">
        <property type="protein sequence ID" value="KAK4041074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SS39"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018834">
        <property type="entry name" value="DNA/RNA-bd_Est1-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019458">
        <property type="entry name" value="Est1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045153">
        <property type="entry name" value="Est1/Ebs1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696:SF36">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696">
        <property type="entry name" value="SMG-7 SUPPRESSOR WITH MORPHOLOGICAL EFFECT ON GENITALIA PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10374">
        <property type="entry name" value="EST1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10373">
        <property type="entry name" value="EST1_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Telomerase activating protein Est1-like N-terminal" evidence="4">
        <location>
            <begin position="83"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="DNA/RNA-binding" evidence="3">
        <location>
            <begin position="210"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="608"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="668"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="757"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="807"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="903"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="953"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="672"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="844"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="903"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="913"/>
            <end position="924"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU369098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4041074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1003" mass="109557" checksum="32C1EB135A659117" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SSB7</accession>
    <name>A0AAN6SSB7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc finger CCCH domain-containing protein 45</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_46138</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854375">
        <property type="protein sequence ID" value="KAK4040505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SSB7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990247">
        <property type="term" value="F:N6-methyladenosine-containing RNA reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21134">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.590.10">
        <property type="entry name" value="ph1033 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057720">
        <property type="entry name" value="RRM_YTH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007275">
        <property type="entry name" value="YTH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045168">
        <property type="entry name" value="YTH_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357:SF3">
        <property type="entry name" value="YTH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357">
        <property type="entry name" value="YTH YT521-B HOMOLOGY DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25701">
        <property type="entry name" value="RRM_YTH1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50882">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="393"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="474"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="511"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="325"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4040505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="641" mass="68123" checksum="B5479E5E2C0F27B4" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SSH9</accession>
    <name>A0AAN6SSH9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nuclear distribution protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_34434</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854356">
        <property type="protein sequence ID" value="KAK4041479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SSH9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4041479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="218" mass="23727" checksum="7640FDFAAFD06A2D" modified="2024-10-02" version="1">MDNTLDQTTLGTISLLEARLRRIEHILYGPATPPTQPPQESATTSLAELEHRFTQLLRHFRVYAEILKIYKSHPSLFQSPSTTTAIPPLNNQTATADLPPTQLAPEAVRATVLAYATAFPSTASALTAATSDTPVPDAKQSAALAALGPRMRGLEALQRAQAAEMSDLRMRSERAVRAWYEGGVLRYGAALAGVEGRLEGVERGVRRVGRGREEREKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SSM3</accession>
    <name>A0AAN6SSM3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_35415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854374">
        <property type="protein sequence ID" value="KAK4040553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SSM3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042863877" evidence="1">
        <location>
            <begin position="24"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4040553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="182" mass="19270" checksum="56C5ADF04D20B749" modified="2024-10-02" version="1">MLRLGPVAFPIALASFAIQAAIAQKGTFNLFGYGPGIGGSSLTNTNDTTPDDNTFSNATFYVPTTTNNSATTNSNRQAGFLPANKTASSADMTVAGWQFYGQALLLVGSDGAWNSLFYAEAPYEDGLWTLSWNSTSKDSGAVPLAIRSTPPAAPEDDDDAAYSVSQLRHVENLGSLKHVVYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SSN2</accession>
    <name>A0AAN6SSN2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_46060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854373">
        <property type="protein sequence ID" value="KAK4040583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SSN2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4040583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="293" mass="32764" checksum="C43182B2ED70C3F6" modified="2024-10-02" version="1">MPLTTSQDQESQPPTMRFTSTQRLFRCIYDEVRVPGDVLTIDRVREARRRKFRLRRYDSASGILTIAVPTRLHETLHLQLRDMLLAQLVYGGIERDWVSMGAPTLHTTAEGPPYPGGKGGRGALVGLLEGDSTGGPWPARGGPDHWPTLVVLAGESESLEELRGHMEWWFAKSRHEVKIVLLAKFDHGRQVVVLERWEEEEPPARAGATTTRLNDSLWRPALRQEITIGRDGSTDPVSYHVTGGELVLGFRQLFLRGPGPGEPGEVVLSVEDLEKYAERVWSMVRDVDEAGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SSV8</accession>
    <name>A0AAN6SSV8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Uracil catabolism protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_35136</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854368">
        <property type="protein sequence ID" value="KAK4040866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SSV8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012469">
        <property type="entry name" value="DUF1688"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31687">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31687:SF3">
        <property type="entry name" value="PROTEIN URG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07958">
        <property type="entry name" value="DUF1688"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4040866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="544" mass="59268" checksum="613640B863C85BF6" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SSX1</accession>
    <name>A0AAN6SSX1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_45874</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854368">
        <property type="protein sequence ID" value="KAK4040853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SSX1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015606">
        <property type="term" value="F:spermidine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000297">
        <property type="term" value="F:spermine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140115">
        <property type="term" value="P:export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042908">
        <property type="term" value="P:xenobiotic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF38">
        <property type="entry name" value="POLYAMINE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="380"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="418"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="443"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="40"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK4040853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="501" mass="54497" checksum="ED1A09C5A57979ED" modified="2024-10-02" version="1">MADAQEAPQTTDSGDASDDWNGPDDPDCPYNWPLWKRIYTTSIPALLCINVSFASSVYTSGADDISREFGVSHTESLLGLSLFLWALGLGAIIAAPVSEYYGRRIVYLTTVPVFGFFILGSGLAQNFVTLAVCRTLAGFFGSAVVSVGGGTNADLWPPALAGFVYPFYFVSPFLGPAFGPVIGGFLSEAKGFRWLEWVILFMVAFNYLYALPQSESYKKTILQKRMRAEKRANAPPSRPLNVALPSSAVVQRIVLKPFKMLFVESIVLFMTIYMAFNFAVFYSFFAAFPYIFGAGGKYNFTPGQQGLTFISIALGCVIGFLAVVYIDRRTYPALEAKYGVGAVPPEYRLYGAMVGCALNPASLFWFGWAADAGTYWPSPVVAAVPFAVGNIMVYSSGALYIMNAYGSLHGASALSANSLLRYAGGGAFPLFTVQMFSSLGIGWASSLLGFVSVALVPVPWVLYKYGSRIRARSQYITIKEPGMENWNSSREMTSEGEEVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6STQ9</accession>
    <name>A0AAN6STQ9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal protein S14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_33965</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854348">
        <property type="protein sequence ID" value="KAK4041975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6STQ9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1480:FF:000001">
        <property type="entry name" value="30S ribosomal protein S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001209">
        <property type="entry name" value="Ribosomal_uS14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018271">
        <property type="entry name" value="Ribosomal_uS14_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006477">
        <property type="entry name" value="PRK08881.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19836">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19836:SF19">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US14M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00253">
        <property type="entry name" value="Ribosomal_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00527">
        <property type="entry name" value="RIBOSOMAL_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4041975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="113" mass="12999" checksum="39594A0546652E32" modified="2024-10-02" version="1">MSMFRAKKLDLGCFTNIKIIRDHSKRKAYEAAEAERQALRYIVRNTTLPPRTRAIAQLQLTQMHCYTRPTQIRNRCILGGKGRGILGDFKMSRFNFRMQALAGNIPGVKKASW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6STX8</accession>
    <name>A0AAN6STX8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_32923</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854333">
        <property type="protein sequence ID" value="KAK4042979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6STX8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="206"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4042979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="349" mass="37906" checksum="56980F9D02AAE38A" modified="2024-10-02" version="1">MSSLDLDQVLYARAGWRKVILVPLWTFQIAVLLCLMGIFAYRLAETFEHYEELDKMGEVPIVEVVWEATNVGFNLIALVLNIVEIARKATERLTPFTMVFTHVLKLTLAFAVLALDIVAYLQRMDGHYSTIGLSLDCGAANLITFTYSLITYRKQLKYEEYRLTANTKAQVYAGDESLELGYHPKHGHRSGGITTTRTTELHYSDNSTSSYPSQPQTQPSTGSNPSPSGSVLKKEVDRAMGAEFGWSTPPPHRSHHSDSNHSSDEAVNRSGSVVVASGKVPVHHGGLVVAAPVEGGLQRQQSWVTEQGVVAEEDGEGVMGRGGEAGGHYSGQGGSGSGEEDEEALLPGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SU05</accession>
    <name>A0AAN6SU05_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Gluconokinase</fullName>
            <ecNumber evidence="3 9">2.7.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">C8A01DRAFT_44870</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>D-gluconate + ATP = 6-phospho-D-gluconate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19433"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18391"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Carbohydrate acid metabolism; D-gluconate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the gluconokinase GntK/GntV family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.12" evidence="3 9"/>
    <dbReference type="EMBL" id="MU854346">
        <property type="protein sequence ID" value="KAK4042096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SU05"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046316">
        <property type="term" value="F:gluconokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02021">
        <property type="entry name" value="GntK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001607">
        <property type="entry name" value="Gluconokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031322">
        <property type="entry name" value="Shikimate/glucono_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006001">
        <property type="entry name" value="Therm_gnt_kin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01313">
        <property type="entry name" value="therm_gnt_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43442">
        <property type="entry name" value="GLUCONOKINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43442:SF3">
        <property type="entry name" value="GLUCONOKINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01202">
        <property type="entry name" value="SKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK4042096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="219" mass="23938" checksum="190EFE9B0A4B46C9" modified="2024-10-02" version="1">MSSGRQSIPPSPKAARLPTALSNGVMANGATSTTESPAKDQHIWLVTGPAGCGKSTVAKHIANSCQLPFIEGDEYHPKANIDKMSAGIPLTDADRWDWLTALREASILELDKGSDGVVLTCSALKRKYRDVIRVAPYFTPNIHLHFIYLDAPEEVLLQRVSARQNHYMGANMVHSQFEVLERPKADEVDVITIDVTRPAEAVMAEALDKAIKTMDSTQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SU63</accession>
    <name>A0AAN6SU63_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptidyl-prolyl cis-trans isomerase E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_44650</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854343">
        <property type="protein sequence ID" value="KAK4042261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SU63"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12347">
        <property type="entry name" value="RRM_PPIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034168">
        <property type="entry name" value="PPIE_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48037">
        <property type="entry name" value="ATPASE E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48037:SF1">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="9"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="119"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4042261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="154" mass="16321" checksum="8DD1754B9DD92BCC" modified="2024-10-02" version="1">MTDTARWKSTVYVGGLAPAVTTTILQEAFLPFGEIADVALPKNENPSTAAAEPHRGFAYVEFEDAEDAKEAIDNMDQAELFGRVIKVSAAKAPKSAAGQGGLGGKTAVWEQEGWLAEHAVSEEDRLAAEQAQNARPDDPMQGLEGLDVAGPKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SU77</accession>
    <name>A0AAN6SU77_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription factor Pcc1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_44572</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CTAG/PCC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854341">
        <property type="protein sequence ID" value="KAK4042440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SU77"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070525">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.50:FF:000011">
        <property type="entry name" value="Transcription factor Pcc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015419">
        <property type="entry name" value="CTAG/Pcc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31283">
        <property type="entry name" value="EKC/KEOPS COMPLEX SUBUNIT PCC1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31283:SF5">
        <property type="entry name" value="EKC_KEOPS COMPLEX SUBUNIT LAGE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09341">
        <property type="entry name" value="Pcc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4042440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="108" mass="11451" checksum="E1C67A986FC57C9A" modified="2024-10-02" version="1">MATDTPAAFPCALTLDVPFPDARLAAVALQALRVDKELSSLVKRDLSAVAPEGSPDATVLRIEYKAATNRMLRVAVNSFLESLALVVEVQEELDVDVVEARQAQGGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SUA1</accession>
    <name>A0AAN6SUA1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SEC7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_44160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854335">
        <property type="protein sequence ID" value="KAK4042802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00171">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056604">
        <property type="entry name" value="GBF1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032691">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HUS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF388">
        <property type="entry name" value="GOLGI-SPECIFIC BREFELDIN A-RESISTANCE GUANINE NUCLEOTIDE EXCHANGE FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12783">
        <property type="entry name" value="Sec7-like_HUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23325">
        <property type="entry name" value="TPR_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEC7" evidence="2">
        <location>
            <begin position="666"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="537"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1338"/>
            <end position="1362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1579"/>
            <end position="1618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="318"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="389"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1604"/>
            <end position="1618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4042802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1618" mass="177617" checksum="B1D5A537C139DBCA" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SUG0</accession>
    <name>A0AAN6SUG0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ABC transporter transmembrane region 2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">C8A01DRAFT_12883</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854326">
        <property type="protein sequence ID" value="KAK4043534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SUG0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015910">
        <property type="term" value="P:long-chain fatty acid import into peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042760">
        <property type="term" value="P:very long-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03223">
        <property type="entry name" value="ABCD_peroxisomal_ALDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000636">
        <property type="entry name" value="ATP-binding cassette sub-family D member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050835">
        <property type="entry name" value="ABC_transporter_sub-D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384">
        <property type="entry name" value="ATP-BINDING CASSETTE, SUB-FAMILY D MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384:SF69">
        <property type="entry name" value="PEROXISOMAL LONG-CHAIN FATTY ACID IMPORT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06472">
        <property type="entry name" value="ABC_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="127"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="470"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="62"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK4043534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="717" mass="80876" checksum="A6FB11C8433098FE" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SUT6</accession>
    <name>A0AAN6SUT6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_32846</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854332">
        <property type="protein sequence ID" value="KAK4043055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SUT6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14137">
        <property type="entry name" value="STKc_GSK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000055">
        <property type="entry name" value="Glycogen synthase kinase-3 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000009">
        <property type="entry name" value="Glycogen synthase kinase-3 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050591">
        <property type="entry name" value="GSK-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039192">
        <property type="entry name" value="STKc_GSK3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24057">
        <property type="entry name" value="GLYCOGEN SYNTHASE KINASE-3 ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24057:SF0">
        <property type="entry name" value="PROTEIN KINASE SHAGGY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="35"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4043055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="394" mass="45100" checksum="606E57A6D8714C77" modified="2024-10-02" version="1">MASNRPAAFNTLRMGEVIREKVQDGVTGETREIQYTQCKIVGNGSFGVVFQTKLSPSNEDAAIKRVLQDKRFKNRELQIMRIVRHPNIVQLKAFYYSNGERKDEVYLNLVQEFVPETVYRASRFFNKMKTTMPTLEVKLYIYQLFRALAYIHSQGICHRDIKPQNLLLDPTTGVLKLCDFGSAKILVENEPNVSYICSRYYRAPELIFGATNYTTKIDVWSTGCVMAELMLGQPLFPGESGIDQLVEIIKVLGTPTREQIRTMNPNYMEHKFPQIKPHPFNKVFRKADANAIDLIARLLEYTPTERLAAVDAMVHPFFDELRDPNTRLPDSRHGTGQVRDLPALFDFSRHELSIAPQLNRQLVPSHMIPVLAARGLDIDNFTPMAKQEMMAKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SV01</accession>
    <name>A0AAN6SV01_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Large subunit GTPase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_43968</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854332">
        <property type="protein sequence ID" value="KAK4043043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SV01"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01857">
        <property type="entry name" value="HSR1_MMR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001558">
        <property type="entry name" value="Ribosome biogenesis GTPase Lsg1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043358">
        <property type="entry name" value="GNL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45709:SF2">
        <property type="entry name" value="LARGE SUBUNIT GTPASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45709">
        <property type="entry name" value="LARGE SUBUNIT GTPASE 1 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CP-type G" evidence="7">
        <location>
            <begin position="175"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="259"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="622"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="265"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="627"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4043043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="652" mass="72177" checksum="EA96A4E01A477758" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SVU8</accession>
    <name>A0AAN6SVU8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CwfJ C-terminus 2-domain-containing protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_43059</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CWF19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854321">
        <property type="protein sequence ID" value="KAK4044135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SVU8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040194">
        <property type="entry name" value="Cwf19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006768">
        <property type="entry name" value="Cwf19-like_C_dom-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006767">
        <property type="entry name" value="Cwf19-like_C_dom-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12072">
        <property type="entry name" value="CWF19, CELL CYCLE CONTROL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12072:SF5">
        <property type="entry name" value="CWF19-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04677">
        <property type="entry name" value="CwfJ_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04676">
        <property type="entry name" value="CwfJ_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cwf19-like C-terminal" evidence="4">
        <location>
            <begin position="484"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="domain" description="Cwf19-like protein C-terminal" evidence="3">
        <location>
            <begin position="622"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="58"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="117"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="135"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="194"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4044135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="731" mass="84026" checksum="332185860C894C69" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
            <fullName evidence="7">BZIP domain-containing protein</fullName>
        </recommendedName>
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        <name evidence="8" type="ORF">C8A01DRAFT_43165</name>
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        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAK4044003.1"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
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        <property type="entry name" value="ACTIVATING TRANSCRIPTION FACTOR ATF 4/5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13044:SF14">
        <property type="entry name" value="CRYPTOCEPHAL, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="7">
        <location>
            <begin position="355"/>
            <end position="418"/>
        </location>
    </feature>
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        <location>
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            <end position="182"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </location>
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            <end position="427"/>
        </location>
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    <feature type="compositionally biased region" description="Pro residues" evidence="6">
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            <end position="594"/>
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            <end position="627"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        </source>
    </evidence>
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        </source>
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        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SWC9</accession>
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            <fullName evidence="9">Kinesin light chain</fullName>
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        <name type="scientific">Parachaetomium inaequale</name>
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        </lineage>
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    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
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        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAK4044690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SWC9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="entry name" value="SERAC1"/>
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    </dbReference>
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        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182:SF2">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="691"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="739"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="781"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="458"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4044690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="880" mass="98176" checksum="D21D511D4AAE3F65" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P4B4</accession>
    <name>A0AAN6P4B4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_51456</name>
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    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Sordariomycetidae</taxon>
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            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the ustYa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854795">
        <property type="protein sequence ID" value="KAK4031473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P4B4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF4">
        <property type="entry name" value="CYCLOCHLOROTINE BIOSYNTHESIS PROTEIN O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0843">Virulence</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4031473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="246" mass="28237" checksum="71925668AEF46776" modified="2024-10-02" version="1">MGTRQLQWTSVLPPFILVCAAVVVFAAFRVHPSDALYPWSPALEMVEYHWETFQNHQFSISTPYFGFTPSDQIENAWNGLLPKHPIAIPPSRLGDLGRAGSEDDSSWVRDPKNPDAILALPEYAVQLTCLNFLRQVGYRAERDFTHLKRFSGGEDLMWERAYQCLERLRHAIMCWGDVSAIPLFYDDHGRPTQEGTDRNDVSFDFGSLEYCRNFDALNEWTQKNGVQDVLMDDFWWGGHSNTRTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P658</accession>
    <name>A0AAN6P658_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Calcium-binding protein NCS-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_41058</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the recoverin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854604">
        <property type="protein sequence ID" value="KAK4032494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P658"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000009">
        <property type="entry name" value="Visinin-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028846">
        <property type="entry name" value="Recoverin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055">
        <property type="entry name" value="CALCIUM BINDING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055:SF178">
        <property type="entry name" value="NEUROCALCIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00036">
        <property type="entry name" value="EF-hand_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="61"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="97"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="145"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00071944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4032494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="191" mass="22099" checksum="614C63A5C431053B" modified="2024-10-02" version="1">MGNLQSKKLPDDQLKELQRSTNFDKKELQQWYRGFLKDCPSGMLTKSEFQKIYAQFFPFGDPSTFADYVFNVFDTDKSGTIDFKEFICALSVTSRGKMEDKLDWAFQLYDIDGDGKISYDEMLKIVEAIYKMVGSMVKLPEDEDTPEKRVRKIFRMMDKDENGSLDMQEFKEGSQRDATIVSALSLYDGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P674</accession>
    <name>A0AAN6P674_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Thymidylate synthase</fullName>
            <ecNumber evidence="4">2.1.1.45</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">C8A01DRAFT_41205</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>dUMP + (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate = 7,8-dihydrofolate + dTMP</text>
            <dbReference type="Rhea" id="RHEA:12104"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57451"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="2.1.1.45"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; dTTP biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the thymidylate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.45" evidence="4"/>
    <dbReference type="EMBL" id="MU854619">
        <property type="protein sequence ID" value="KAK4032365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P674"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004799">
        <property type="term" value="F:thymidylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006231">
        <property type="term" value="P:dTMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00351">
        <property type="entry name" value="TS_Pyrimidine_HMase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.572.10:FF:000005">
        <property type="entry name" value="Thymidylate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.572.10">
        <property type="entry name" value="Thymidylate synthase/dCMP hydroxymethylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00008">
        <property type="entry name" value="Thymidy_synth_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045097">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023451">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036926">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000398">
        <property type="entry name" value="Thymidylate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020940">
        <property type="entry name" value="Thymidylate_synthase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03284">
        <property type="entry name" value="thym_sym"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11548:SF2">
        <property type="entry name" value="THYMIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11548">
        <property type="entry name" value="THYMIDYLATE SYNTHASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00303">
        <property type="entry name" value="Thymidylat_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00108">
        <property type="entry name" value="THYMDSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55831">
        <property type="entry name" value="Thymidylate synthase/dCMP hydroxymethylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00091">
        <property type="entry name" value="THYMIDYLATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylate synthase/dCMP hydroxymethylase" evidence="12">
        <location>
            <begin position="25"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK4032365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="339" mass="37928" checksum="72D10E6DD52649A0" modified="2024-10-02" version="1">MTVSQNDSPAAAPTTSSEPRHEEYQYLDLVREILDQGELRRDRTGTGTYSIFAPRPLKFSLNRAGAPILPLLTTKRVFTKAVIAELLWFISGDTSAHTLSAQGVKIWDGNGSRAFLDNLGLTDREVGDLGPVYGFQWRHFGAEYVDAKTDYTGQGVDQLARIVHTLRTNPFDRRLVLSAWNPADMARMVLPPCHMFAQFYVSYPGSRSTTTAPQEGEEEKKKPAVKGHLHCQLYQRSCDMGLGVPFNIASYALLTHMLAHVCDLVPGSLTHVMGDAHVYLNHVEALQTQLGREPRDFPELEIANDRRENGERSIDGWKAEDFVIKGYNPHKIIAMEMSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P6B9</accession>
    <name>A0AAN6P6B9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_20337</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854593">
        <property type="protein sequence ID" value="KAK4032584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P6B9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030798">
        <property type="term" value="F:trans-aconitate 2-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.290">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023149">
        <property type="entry name" value="Trans_acon_MeTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861:SF1">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="4">
        <location>
            <begin position="51"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4032584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="284" mass="31618" checksum="E5A3EE2F1FB1FB3D" modified="2024-10-02" version="1">MSSSPKTSNRSPPESTSDWSPDQYLLFRQARDRPIRDLIAFLGPDYAPKHITDLGCGPGTSTALLAARFPSAHLTGVDSSPAMLARARTALPSSVASFAQADVRTYLPDPHTTDLLFSNAVFHWLRTPERLPTITRLLRTLPKGGVLALQVPDNYDEPSHRAMREAAAAPGPWRAYFAALPPDKRPELDPVEPVVAYYDALRPHCSEVEIWTTQYVHVLEDHGGIVEWVKGTGLQPFVNALPEEDGVREGLLRAYRERLEEGYPRAGDGKVLLRYPRRFMVAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P6Q0</accession>
    <name>A0AAN6P6Q0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">C8A01DRAFT_40802</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854578">
        <property type="protein sequence ID" value="KAK4032763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P6Q0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048685">
        <property type="entry name" value="COG3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048320">
        <property type="entry name" value="COG3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007265">
        <property type="entry name" value="COG_su3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13302">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13302:SF8">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20671">
        <property type="entry name" value="COG3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04136">
        <property type="entry name" value="COG3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 3 N-terminal" evidence="10">
        <location>
            <begin position="142"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 3 C-terminal" evidence="11">
        <location>
            <begin position="306"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="587"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="756"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="592"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="778"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF20671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK4032763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="778" mass="84314" checksum="C9DE808A9ED47052" modified="2024-10-02" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P7I8</accession>
    <name>A0AAN6P7I8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_19822</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854546">
        <property type="protein sequence ID" value="KAK4033199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P7I8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.280.10">
        <property type="entry name" value="SRA-YDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036987">
        <property type="entry name" value="SRA-YDG_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4033199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="265" mass="29963" checksum="AD3F05F5E2501AE3" modified="2024-10-02" version="1" fragment="single">WWLNLACAHLDGLVGAGRETTSMGDGKAPTLPFLTGREIHAGHNRLRYLRESTLAGMPPALVPQTGKHVRVLSGNQLHSHLAPRIGIRDDGLRKVLKHSERLIHTTGRYRLEVDLEKSPGQPAMSELMRIPRSSHLDDWDLYKRLKADKDTQGAYRHGSSWSEEAGMVVKHPRKLQQSNHKTTTTGLVGSNPRVKHQSQGSENGLSGRQRRMKGKTRLSLLSSRNKQVVPVEEMGERVQRRRDMTCRDPRNQEHFSRPTSISHRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P8D1</accession>
    <name>A0AAN6P8D1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metapyrocatechase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_49876</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854522">
        <property type="protein sequence ID" value="KAK4033565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P8D1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004493">
        <property type="term" value="F:methylmalonyl-CoA epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046491">
        <property type="term" value="P:L-methylmalonyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.180.10:FF:000034">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.180.10:FF:000039">
        <property type="entry name" value="Trihydroxytoluene oxygenase (AFU_orthologue AFUA_8G02470)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051785">
        <property type="entry name" value="MMCE/EMCE_epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43048">
        <property type="entry name" value="METHYLMALONYL-COA EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43048:SF3">
        <property type="entry name" value="METHYLMALONYL-COA EPIMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="171"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4033565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="327" mass="37450" checksum="98E32787B2B1A822" modified="2024-10-02" version="1">MASGLPSNPPKKIQLVRIAHVWYKHADIEKAKQFALDFGFVETAQVGKTTFYRGYGTEPFALAFEASDKDEFGGAAFVVESEEDLVHASKSLPKECRATEVHEMKDMPGGGKRVTFFDPVDGFPFHLVHGQTPVAREDPGFPALRYNYPVEKNRGVNEFQRFKKRPAPVHKLGHFGMCVTNYAKCYEFYSSYFNFHPSELVHNDEKVDITVFFRLDRGADLVDHHCFFFFEGPKMHVHHSSFETHDFDAQVLGHDWLRQKGYTNCWGVGRHVMGSQIFDYWFDPAGFIMEHYVDGDLLDMTEPTHHNKAAPDNLHVWGPDVPPTFLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P8I0</accession>
    <name>A0AAN6P8I0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_49743</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854513">
        <property type="protein sequence ID" value="KAK4033723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P8I0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF512">
        <property type="entry name" value="SOBREMESA, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="395"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4033723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="428" mass="45015" checksum="51BCAEE7BD892293" modified="2024-10-02" version="1">MASSSVTTPLLADDAPRQQSPRAQHRAELNTAPKKRLLNFWDGVSLTLGIQIGSGIFISPALVARNTSSELPALAVWTAGGLLAWACAACYIEMGTRLPVNGGPQEYLAHCFGDLLGFMASWGCIFGIKPCSAAILALFIADYVCDVAGFGYRGLVALGVVALVTAVNCTGNRLSNVSTKILLACKTIGVGFVIVMGFAVLILPDLLPPPPADAPREPPPAKGDAGSYTDALVAAMWAYSGWEVLSFVGGDLQNPSRNVPRVINVSMVVVLAFTLFANVAYFSALSFDEVARSTTVGLTFSQRFLGRAGSIIYAVAICLSSLGTLNVKTFAAGRLTQAAAERGYLPLLMKTVASGSDEDEESDGDHLSEVQSARSMFSFLGRPARFGDGSIPLSAILFNSLLASAFVLAGDISALISLMGEIYRIPKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P8K4</accession>
    <name>A0AAN6P8K4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7730 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_20183</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854574">
        <property type="protein sequence ID" value="KAK4032797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P8K4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056632">
        <property type="entry name" value="DUF7730"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790:SF4">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24864">
        <property type="entry name" value="DUF7730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7730" evidence="1">
        <location>
            <begin position="35"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4032797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="222" mass="26387" checksum="1C70F1C19FB1D551" modified="2024-10-02" version="1">MQLNKERQRKIRNLLHKSLPREDTAELALWQRNRQLSPLLRLPPELRNRVFELVLDVGQINVCFKKWEHRARTKNGHRCYETVEGGFWCRILDKDQNPWRDPKAKPADTPPRRGMTLLSPVCRQLYHETALLPFRLNAWSFESMHVMDRYVMKEKRLPLSHRRAIRLLYAQMVLPTPVEKYFGGLEVVVLGTGLTMVKRVEDGAEHGQRKTVTWDLYHKKWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P8Q8</accession>
    <name>A0AAN6P8Q8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_39733</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854509">
        <property type="protein sequence ID" value="KAK4033804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P8Q8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF5">
        <property type="entry name" value="HEAT SHOCK 70 KDA PROTEIN 12A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4033804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="194" mass="21103" checksum="446368A00BDAC5DF" modified="2024-10-02" version="1">MELAFHRAPCNDTGYRFDIGIDFGATCSGVTVKITDKTNGPGPYQSVASWPQPSAGHHPPATACKTPTRLSLSSPSLGTSEPVLWGSQVPDDGESLRWFKLGLVHEDDLAEDPFDGFLQDVQESTELDDAKTLRRQHHTTATKVCKVYLSKLASHVLEYIALKTGLTMAQVLASELHFVVGVPANWQTATLARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P8R0</accession>
    <name>A0AAN6P8R0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Monooxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_39744</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854509">
        <property type="protein sequence ID" value="KAK4033814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P8R0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000331">
        <property type="entry name" value="FAD/NAD(P)-binding domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF187">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-dependent oxidoreductase 2 FAD-binding" evidence="6">
        <location>
            <begin position="10"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="7">
        <location>
            <begin position="155"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4033814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="438" mass="49361" checksum="DC89D9D90F12703D" modified="2024-10-02" version="1">MSVPKSGIKVVVVGAGFGGLTAAIECHRQGHDVSIYENFAELKILGDIISFGANAGRIYHRWSDGKIARRLRELCIDLSEYGFRIHKYDTGEVVYHQKTPEQDPEAPVMNGHRGELHEVVFNYARDELGIPIHLGQPVEEYFEDENQGGIVLKSGERVVADLVIGADGVRSKARELVLGYVDKPKSSGYAVWRAWFSNTDMIKDPRTREFCINGDTFNGWIGPDVHFLFSTIKGGQDCCWVLTHRDEHDIDESWSFPGKLEEVYKVLEGWDPLCRAIVEKTPSLVDWKLVYRDPLPTWVSKHARILLLGDAAHPFLPTSAQGATQAMEDGVTIAVCLKRAGKANIPAAVRVHQEIRYDRVGAVQKTGETTRDRWHKTDWENVAKDPKSIAFPREDWIHHHDAEKHAEDLFDETFKKVTQPELFENVKLLPLGPIPVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P9L6</accession>
    <name>A0AAN6P9L6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_18881</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854485">
        <property type="protein sequence ID" value="KAK4034291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P9L6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4034291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="403" mass="44416" checksum="62A637875E323810" modified="2024-10-02" version="1">MTKIKGPGSERVDATDSLQAVIAEVDPKTEILHITGDVPTNDEWEALGQHFTGVRFLNVATGWDENWIDDKFPLNWPIELLIIADAISERISTPAIMEGRIKHLILFFTCGLRFEGPSVKELIKDAEVIFTIPRKKAPDAETQAEGALSEGAVSQAEENQPADSDSATKSAPESDVIKVTSYADRDITFSPDRGDAPPSEMKTLEILGNDALEMLTYIALAKFHLLTSLESLTLLSSHGNDLRHVPATLFPCFLPALDELKHFKLTLGSDVHAKILDVILGNKPYLHMILPPNIETLRFRGPVSMTSHMDTLAAAFADDAAFLPRLKRISLLLDLPEKASEHPKEASLEQLRAAHAACKRVLDAAAGRGVVVEAFKEPWVEEHEGLFRAVDNRWAVLDDIARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PA41</accession>
    <name>A0AAN6PA41_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Copper transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_38992</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854475">
        <property type="protein sequence ID" value="KAK4034561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PA41"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005375">
        <property type="term" value="F:copper ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007274">
        <property type="entry name" value="Cop_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483:SF79">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 31 COPPER TRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04145">
        <property type="entry name" value="Ctr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="4" id="KW-0187">Copper transport</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="154"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4034561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="205" mass="21468" checksum="748D33DA1502DE2A" modified="2024-10-02" version="1">MDHGGHGEEMGATGVACKISMLWNWYTIDACFLSSSWQITSNGAFAATCIGVILMVVVLEGLRRLGKEYDEHIQRDFAARVALIASAPVTAVAGSSSASAGACPAGGVRNGEAQAPQTVTFRASPLQQFVRAVIHAATFGLAYIVMLLAMYYNGYIIICILIGALLGKFLCDWMTRTVVIGGVENGVVKGGNTAAGVEEPTVCCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PAJ7</accession>
    <name>A0AAN6PAJ7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial</fullName>
            <ecNumber evidence="11">1.14.15.45</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">2-methoxy-6-polyprenolphenol 4-hydroxylase</fullName>
            <ecNumber evidence="11">1.14.15.46</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">COQ6</name>
        <name evidence="13" type="ORF">C8A01DRAFT_18464</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">FAD-dependent monooxygenase required for two non-consecutive steps during ubiquinone biosynthesis. Required for the C5-ring hydroxylation during ubiquinone biosynthesis by catalyzing the hydroxylation of 4-hydroxy-3-(all-trans-polyprenyl)benzoic acid to 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoic acid. Also acts downstream of coq4, for the C1-hydroxylation during ubiquinone biosynthesis by catalyzing the hydroxylation of 2-methoxy-6-(all-trans-polyprenyl)phenol to 2-methoxy-6-(all-trans-polyprenyl)benzene-1,4-diol. The electrons required for the hydroxylation reaction are funneled indirectly to coq6 from NADPH via a ferredoxin/ferredoxin reductase system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 2-methoxy-6-(all-trans-polyprenyl)phenol + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = a 2-methoxy-6-(all-trans-polyprenyl)benzene-1,4-diol + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O</text>
            <dbReference type="Rhea" id="RHEA:81183"/>
            <dbReference type="Rhea" id="RHEA-COMP:9551"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10858"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:62731"/>
            <dbReference type="ChEBI" id="CHEBI:84166"/>
            <dbReference type="EC" id="1.14.15.46"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 4-hydroxy-3-(all-trans-polyprenyl)benzoate + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = a 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoate + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O</text>
            <dbReference type="Rhea" id="RHEA:81195"/>
            <dbReference type="Rhea" id="RHEA-COMP:9514"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10930"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:64694"/>
            <dbReference type="ChEBI" id="CHEBI:78396"/>
            <dbReference type="EC" id="1.14.15.45"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="11">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Mitochondrion inner membrane</location>
            <topology evidence="11">Peripheral membrane protein</topology>
            <orientation evidence="11">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the UbiH/COQ6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.15.45" evidence="11"/>
    <dbReference type="EC" id="1.14.15.46" evidence="11"/>
    <dbReference type="EMBL" id="MU854465">
        <property type="protein sequence ID" value="KAK4034789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PAJ7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120538">
        <property type="term" value="F:2-methoxy-6-polyprenolphenol 4-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106364">
        <property type="term" value="F:4-hydroxy-3-all-trans-polyprenylbenzoate oxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000021">
        <property type="entry name" value="Ubiquinone biosynthesis monooxygenase COQ6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000245">
        <property type="entry name" value="Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03193">
        <property type="entry name" value="COQ6_monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018168">
        <property type="entry name" value="Ubi_Hdrlase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010971">
        <property type="entry name" value="UbiH/COQ6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051205">
        <property type="entry name" value="UbiH/COQ6_monooxygenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000689">
        <property type="entry name" value="UbQ_mOase_COQ6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01988">
        <property type="entry name" value="Ubi-OHases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43876">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS MONOOXYGENASE COQ6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43876:SF7">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS MONOOXYGENASE COQ6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01304">
        <property type="entry name" value="UBIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0274">FAD</keyword>
    <keyword evidence="3 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8 11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="domain" description="FAD-binding" evidence="12">
        <location>
            <begin position="37"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK4034789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="487" mass="52867" checksum="2FF82E7526E8E189" modified="2024-10-02" version="1">MDAAIRRRGAYVCRSCTRSLQRQLRRTYSSAAQPDIYDVVCVGGGPAGLSLLTALRASPATAHLRVALVEAQDLAKIRSWKLPPDRFSNRCSSLTPSSALFLDQIGAWKHLERDRVQAYQEMQVWDGVTGARIEFDWAGSAPAAGTTIAYMNENLNLTSGLLKRLEELGGVSVFDKAKVESIAYGEETEELDLREWPVVHLSGGKQLSARLLVGADGANSPVRSFAGIEARGWDYNRHGVVATLQIEGEGWGADHSKIAYQRFLPTGPVAMLPLPGNYSTLVWSTTPSNASLLKSLSAKDFIAMVNAAFRLTPTDLEYMHTQESGQAEEYSWRLEHTPFDYRAVPQTAMGVQEGTVASFPLKLRHADTYIAERVALIGDAAHTIHPLAGQGLNQGQGDVQSLAKTIEYAVSHGQDIGVTMSLEPYLSERYAANHLLLGVCDKLHKLYSVGSGPLVPLRSVGLSAVNALGPLKAFFMNQAAGNGIKVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PAR4</accession>
    <name>A0AAN6PAR4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1742-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_48774</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854460">
        <property type="protein sequence ID" value="KAK4034944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PAR4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013640">
        <property type="entry name" value="Vfa1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28218">
        <property type="entry name" value="VPS4-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28218:SF1">
        <property type="entry name" value="VPS4-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08432">
        <property type="entry name" value="Vfa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4034944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="184" mass="21452" checksum="9303D1081BC03321" modified="2024-10-02" version="1">MAFPNVYTHRKVAETKAKSCDICFKLSASVLITPDNKDWFYVCPAHLKDTGFCTPKIDHAAVEARKKRELEEEVERVKKEYEEKQKKKKEKEEKAAKKDEAGDKKSKDDKADEDKQKTADKTEPKNDDSAASPVDDEEEPRVFELKSTFYQQRLNRKRQVEIAKRNRERMQDPTFFPSVPKNLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PAZ2</accession>
    <name>A0AAN6PAZ2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_19117</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854499">
        <property type="protein sequence ID" value="KAK4034012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PAZ2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4034012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="98" mass="11076" checksum="A4588C9E3604A900" modified="2024-10-02" version="1">MCLVTHYRDFHCGHRWATIAMPCYPGMGFDTCPEFVDGQVKPLPPRLVAQGERCPKCDLGNNYDRNMTRMVTKIRYGFRWGLGPNATDPGCDIACCVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PBK6</accession>
    <name>A0AAN6PBK6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_39732</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854509">
        <property type="protein sequence ID" value="KAK4033803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PBK6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4033803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="385" mass="43907" checksum="DADDFC364BD43697" modified="2024-10-02" version="1">MLRPSLPRKCKAPRSVASKATRSVVGTAPKTRQNGARPTKRGASNSSKKAPHRDVMEEEPTVSQPPPPPGTTNNERSSIMNPGWGTQHGSGEAPARRHAKDEYKSPALGHFSKLLAFHDEGHIEFVEERWVDFQSSILMLARRGCVETVSWETLGSETQDMLKVWAPKAKEYLETREGAKVIFEGWLWRILVNDIFNGPGEQQHWKVYTDLQRMIEPLAAMTPDQVTDYQLDRHLKKGEWRQVMADTLKDRYLLWRALTMDLVRALHKQEARYTVEYVAGLLNRKLGSYFQPEIHRRTWDDLQKNVDELARRAVALDWHMHCSTTKWDFGFTDPETGTAHGFVYKKSHFIEPHVVSADEAGYPVDLVVRPLVLSQGDFLGPEMGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PC17</accession>
    <name>A0AAN6PC17_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_37894</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854437">
        <property type="protein sequence ID" value="KAK4038192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PC17"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042924183" evidence="2">
        <location>
            <begin position="19"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4038192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="237" mass="24821" checksum="BA598BE76CD779A3" modified="2024-10-02" version="1">MRLPTVVFWLLLSPPTSATPPNTPNRLSPRSKTKNLLPKQDSSSDCPTAYPTPRSSPPDTEPPYPIQITISPPDSNSQQAQDTGTDSDSDTTSQPRPQPPPKKRPQPPNTEKKRDSNPPPPVEIAFALPANSSSTQSASGDSGPCTLFLDLSSPAAQVSGAATVNVYALDGPAAGSLVGTTRFAAGEVATVDSFACREEEMCFRLEVADDDNGDGTTGVGFLQGDGEGMGLGMRYGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PCA3</accession>
    <name>A0AAN6PCA3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Pectate lyase</fullName>
            <ecNumber evidence="10">4.2.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">C8A01DRAFT_50043</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Pectinolytic enzyme consist of four classes of enzymes: pectin lyase, polygalacturonase, pectin methylesterase and rhamnogalacturonase. Among pectinolytic enzymes, pectin lyase is the most important in depolymerization of pectin, since it cleaves internal glycosidic bonds of highly methylated pectins. Favors pectate, the anion, over pectin, the methyl ester.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Eliminative cleavage of (1-&gt;4)-alpha-D-galacturonan to give oligosaccharides with 4-deoxy-alpha-D-galact-4-enuronosyl groups at their non-reducing ends.</text>
            <dbReference type="EC" id="4.2.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 10">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the polysaccharide lyase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.2" evidence="10"/>
    <dbReference type="EMBL" id="MU854535">
        <property type="protein sequence ID" value="KAK4033362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PCA3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030570">
        <property type="term" value="F:pectate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004898">
        <property type="entry name" value="Pectate_lyase_PlyH/PlyE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33407">
        <property type="entry name" value="PECTATE LYASE F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33407:SF9">
        <property type="entry name" value="PECTATE LYASE F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03211">
        <property type="entry name" value="Pectate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0106">Calcium</keyword>
    <keyword evidence="8 10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042828130" description="Pectate lyase" evidence="11">
        <location>
            <begin position="16"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK4033362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="340" mass="34883" checksum="3598CCF040D3177E" modified="2024-10-02" version="1">MHRYALLGFLPAALGCLDPNSNACASFMNANQATASAFCATFTQAAVKATTGLPAWATACGNKPSQISKECSCYFTAGGAAPTSASSVKVISSAKPTTMVTATTKVTAVASGVTTTLPKSSGATATSKPITVPAGQSYDGGMKNFDRSPRVCAEQEETGEDDAMFVLEDGATLSNVIIGPNQAEGVHCKGICTLVNVWFEDVCEDAITLKQASGTSNIIGGGAFHASDKVVQFNGFGTVSIKNFYINDYGKGVRSCGNCDVNGKARHVVMENVVAVDGGVLCGINTNYGDTCTITNSCQDKGKSCDMFTGNNNGDEPPKIGSGPDGKSCIVTGLTQTCSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PCA9</accession>
    <name>A0AAN6PCA9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_17873</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the NRP synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854443">
        <property type="protein sequence ID" value="KAK4035449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.30:FF:000002">
        <property type="entry name" value="Nonribosomal peptide synthase Pes1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000015">
        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45398">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45398:SF1">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="20"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="278"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="1828"/>
            <end position="1904"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1904"/>
            <end position="1924"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2504"/>
            <end position="2553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2830"/>
            <end position="2896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1914"/>
            <end position="1924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="2510"/>
            <end position="2525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="2839"/>
            <end position="2849"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4035449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="2896" mass="315248" checksum="2F0A738E20A3753B" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PEL7</accession>
    <name>A0AAN6PEL7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_17432</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854427">
        <property type="protein sequence ID" value="KAK4038520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PEL7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="289"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4038520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="346" mass="38364" checksum="442B704D1DBEEE62" modified="2024-10-02" version="1" fragment="single">TLAHLSKTCKQLNLVTTPHLYHRPACSNRWLLIRTLIARPDLALCVKQLHDLVLGGLVTGELDDPSVFPPEVARRFENSRFAQVIMVMARQARGNKQKVTMSLWPRLGGRTESLDMLASLCLNVELVRPSAFSSDIFVWNSPNPLMHLSHIRLPDPIGEPETKRISLALLARILTMAPHVTHLRCSLEAVQQSVELLAFPVSTHLIELTLKYSGISAPALTRLLAACPNLRAFDYDGSAHFTPPQVQEALVRHTPKLVSLGLSACIGHLSGNSLTEVMRSLAHCPSSSIWSWIFSICCLGLTMTTIGLTWAPYALSACYRPRYVRSTSTGWQMMRVFSSSSSCETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PFE0</accession>
    <name>A0AAN6PFE0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Monoterpene epsilon-lactone hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_16135</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854388">
        <property type="protein sequence ID" value="KAK4039918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PFE0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF2">
        <property type="entry name" value="ALPHA_BETA-HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="147"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4039918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="400" mass="44827" checksum="ACFDA95C61EEC044" modified="2024-10-02" version="1" fragment="single">LNLGPVSYLDCIVFCVFLAPQLVWQVGFFETAWCALQALPFLLAKLPVAFIRNRYLLPREKRSAFLRRASLFEDVVVRCVRYAFANIPPRIGRVFFAREVALPFLWFRLLRHGYLGSPVHWREHRESEFRGIWLAKDPGKKPDFALYYAHGGGFSMGSSYFYLEYLLTWLSSLSAAGYKNPAIFALEYTLVPDASFPTQVEETLKGYEHVLEVVRDPSVVCVSGDSAGATLILCLLLRLGNNRANGHGHDKQPPPKPALAVLISPWATLVSTRHKNTASDYLDVQQLRHYGAQFAGSRISATDPLVSPGCCKDVLWWKRSSPTKGIVITHGTEEVLAPEIEELVDTLREAKVVVGSKAELGGIHAWPVASLFLSRSREGRLDGLMTMTSEIRHLIPYQNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PFQ2</accession>
    <name>A0AAN6PFQ2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_38381</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="MU854453">
        <property type="protein sequence ID" value="KAK4035177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PFQ2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="5">
        <location>
            <begin position="105"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4035177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="434" mass="46613" checksum="A342013CF585FB46" modified="2024-10-02" version="1" fragment="single">MGRHPQQLIPLGNGIRDGYGGREDGGLRGDYCYVSPGQGHDRIRILVSSKGERDWMQQPEGRSAVALVLSIALVLVVQVAVWVLLMGSMGGVNGPTVVGTATVDLNYTAYEGLRLSNGVDAFLGMRYAAAPLGDLRWRAPLEPVRSETGPVERAVTYPPICLGTGVAYPADGQSEDCLFANVWAPSNATETSKLPVWVFIQGGGYVANSNANYDGAEVVQRSGHNIVMVNFNYRVGLWGFLASERVRDDGALNAGLLDQRMLLKWVKTHIAAFGGDPNHVVIHGASAGAGSVAMHLVAYGGRNDGLFVGGMSESLFFPAQPLVRELEYQFDRAVSQTGCDGAAQGQQMACLRAKDVAVLQSANYAQPFPGRPGPPMPLFYWTPCVDGDFLRDLPYRLFEKGQFVSVPMVFATSTNEGSYFAPDAATPSDVALFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PFR4</accession>
    <name>A0AAN6PFR4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">3-hydroxybenzoate 6-hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_48579</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854452">
        <property type="protein sequence ID" value="KAK4035192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PFR4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF215">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="254"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4035192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="444" mass="48764" checksum="5B273F559FB02EB0" modified="2024-10-02" version="1">MEAGGGEQPERQPSPLGHAGVVGAGIAGLAAAIALRRAGWRVEVFERSQFKNEIGAAITVTPNGALVLNRWGFDMEKAEAVPNLSKVIALATDPRVILDRQEYADRGRELGHGVWSLHRVDLHRGLRDLATTPSADEAGQPVQITLGCAVEEVDCEAGVLKMADGQTVNKDLSLLLSDFTGYPCEARRNNRSIYRWLVSMDDVMADPDLREIYSNEPPGFMAWIDPGTKMLWTTYRCRGGKLLNIALGHQTQPFQVEKNGWHAQVSREEVLATADNYHPSIKKMVSMANEDGIHIHHVSTRPPLDSFVRGRTVVVGDAAHVMMPTHAAGAGISIESAASLEVLFREVNGKDSSTISCRLNLFDKLRIPRCNLTMLASNSKMGRLRQPGVVDEIRKFYHGPLPPPDALPYSEAWRQILFHHDEYRAAEELLAQASSQKSTLAEGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PFS7</accession>
    <name>A0AAN6PFS7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">C8A01DRAFT_46446</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854382">
        <property type="protein sequence ID" value="KAK4040209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PFS7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051735">
        <property type="entry name" value="CFEM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928">
        <property type="entry name" value="CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G14090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928:SF2">
        <property type="entry name" value="GPI ANCHORED CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G10580)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00747">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="6 15" id="KW-0349">Heme</keyword>
    <keyword evidence="10 15" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="9 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043018617" description="CFEM domain-containing protein" evidence="17">
        <location>
            <begin position="19"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="18">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="90"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="94"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="136"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="163"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="176"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="15">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAK4040209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="208" mass="19953" checksum="CC2F44DD3D029C40" modified="2024-10-02" version="1">MKYTTAILALAAATTTSAQDISVFPECSLPCIIDGIGKTSCQATDFACVCKYIDAVKQAATPCVVDKCGIDTALNKVLPATEKFCAAVGGGGDTPAPSSSSSSTLATVTTPTPTSSSSSAAAEEPSPTSTSTPGGGDDDGDDDGDDDDEPTPSGGSSMVTPAPSGTGSAIPSHSHTASATSSVATGGAAAAAVVGSLGMLVLGAVAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PGF5</accession>
    <name>A0AAN6PGF5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fungal-specific transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_17187</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854419">
        <property type="protein sequence ID" value="KAK4038776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PGF5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052761">
        <property type="entry name" value="Fungal_Detox/Toxin_TFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47425">
        <property type="entry name" value="FARB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47425:SF2">
        <property type="entry name" value="FARB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="56"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4038776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="945" mass="102349" checksum="FD8EE0B2495D1F72" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PGM7</accession>
    <name>A0AAN6PGM7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_15505</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854372">
        <property type="protein sequence ID" value="KAK4040644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PGM7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042892839" description="Carboxylesterase type B domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="3">
        <location>
            <begin position="35"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4040644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="626" mass="67548" checksum="5C6CFC156E984948" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PH91</accession>
    <name>A0AAN6PH91_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_35271</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854371">
        <property type="protein sequence ID" value="KAK4040712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PH91"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000009">
        <property type="entry name" value="MFS multidrug transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF4">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="219"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="253"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="282"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="518"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="564"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="606"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="633"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="669"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="701"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="128"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="66"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="337"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="383"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="87"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="396"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4040712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="739" mass="80927" checksum="FED23CF601BBE62F" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PHC6</accession>
    <name>A0AAN6PHC6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Beta-glucosidase cel3A</fullName>
            <ecNumber evidence="5">3.2.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Beta-D-glucoside glucohydrolase cel3A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Cellobiase cel3A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Gentiobiase cel3A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">C8A01DRAFT_46034</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="5"/>
    <dbReference type="EMBL" id="MU854372">
        <property type="protein sequence ID" value="KAK4040662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PHC6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000757">
        <property type="entry name" value="Beta-glucosidase G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000002">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1700:FF:000003">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF28">
        <property type="entry name" value="BETA-GLUCOSIDASE L-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 18" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042877206" description="Beta-glucosidase cel3A" evidence="18">
        <location>
            <begin position="18"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type III-like" evidence="19">
        <location>
            <begin position="654"/>
            <end position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00070030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00078013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00083231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00083611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAK4040662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="735" mass="76980" checksum="E14EF369A52506DD" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PHM7</accession>
    <name>A0AAN6PHM7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_46413</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854381">
        <property type="protein sequence ID" value="KAK4040258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PHM7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031415">
        <property type="term" value="C:NatA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.1040:FF:000003">
        <property type="entry name" value="N-terminal acetyltransferase A, auxiliary subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.1010:FF:000002">
        <property type="entry name" value="N-terminal acetyltransferase catalytic subunit (NAT1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1010">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019171">
        <property type="entry name" value="MIX23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021183">
        <property type="entry name" value="NatA_aux_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767:SF2">
        <property type="entry name" value="N(ALPHA)-ACETYLTRANSFERASE 15_16, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767">
        <property type="entry name" value="N-TERMINAL ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09774">
        <property type="entry name" value="MIX23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12569">
        <property type="entry name" value="NatA_aux_su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000422">
        <property type="entry name" value="N-terminal-AcTrfase-A_aux_su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="229"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="525"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="728"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="754"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="779"/>
            <end position="794"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4040258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="895" mass="101145" checksum="A04AF1D88926753C" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PHX2</accession>
    <name>A0AAN6PHX2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Serine incorporator/TMS membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_34805</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TDE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854362">
        <property type="protein sequence ID" value="KAK4041186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PHX2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005016">
        <property type="entry name" value="TDE1/TMS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10383">
        <property type="entry name" value="SERINE INCORPORATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10383:SF9">
        <property type="entry name" value="SERINE INCORPORATOR, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03348">
        <property type="entry name" value="Serinc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043035577" evidence="8">
        <location>
            <begin position="17"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="420"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="462"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="388"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4041186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="495" mass="54087" checksum="98E3E8AC680F06F0" modified="2024-10-02" version="1">MGALLSIPLMAVPSMGTLLSCAASCCGAATCSMVCSACGKCGNSVATRIAYALILLINSILSWIMLTKWAIEKLQHLMLDYVKIKCGDGDCYGWLAVHRINFALGMFHLVLAGLMLGVHSSKNPRAAIQNGYWGPKIIAWLGLIALTFFIPDTFFQFWGNYVAMVCAMLFLILGLILLVDLAHNWAEYCLAQIEDTESKTWRVILIGSTLGMYLASIAMTIVQYIFFASSGCSMNQAAITINLLLWIAISVVSVHPAIQERNPKAGLAQAAMVAVYCTYLTMSAVSMEPDETEDRRCNPLVLGQGTRTTTIVVGAIVTMLTVAYTTTRAATQSLGMGASRASSGGGQIRLPDSEADYEHDLVTQQPTARKQMRAEALRRAVEEGSLPADALLSDDDDSSSDAGNGATATRNDDERASTQYSYAMFHVIFFLATAWVATLLTMDWDDDSRRDDDFATVGRTLWASWVKIVSSWVCYAMYLWTLVAPVVLPERFEFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PIL9</accession>
    <name>A0AAN6PIL9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">nicotinamidase</fullName>
            <ecNumber evidence="6">3.5.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Nicotinamide deamidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_34515</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; nicotinate biosynthesis; nicotinate from nicotinamide: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.19" evidence="6"/>
    <dbReference type="EMBL" id="MU854357">
        <property type="protein sequence ID" value="KAK4041432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PIL9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008936">
        <property type="term" value="F:nicotinamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019363">
        <property type="term" value="P:pyridine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01011">
        <property type="entry name" value="nicotinamidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052347">
        <property type="entry name" value="Isochorismatase_Nicotinamidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11080:SF2">
        <property type="entry name" value="LD05707P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11080">
        <property type="entry name" value="PYRAZINAMIDASE/NICOTINAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="8">
        <location>
            <begin position="9"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00043224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4041432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="243" mass="26398" checksum="94F6950D0FAC7976" modified="2024-10-02" version="1">MADPAFRPALLVVDMQEDFCPPNGSLAVPEGRSITPLINTLLALPAATLPLKIATKDWHPSDHISFASNHPGPPPKRPFLDTTTITNPLNPSGGESYTTRLWPAHCIQSTPGAALIPELNTTHLTHIIEKGTDPRVEMYSAFYCPLNNPRLPDTDSGLADLLRSRGTTHVYVVGLAADYCVRSTAEDAVREGFEAYVIEEATRAVEPAGWEACKREMEGNGVRVVGWEGLEVRRLFGGGEEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PIT2</accession>
    <name>A0AAN6PIT2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Sulphur transport domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_35209</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854370">
        <property type="protein sequence ID" value="KAK4040740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PIT2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007272">
        <property type="entry name" value="Sulf_transp_TsuA/YedE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30574">
        <property type="entry name" value="INNER MEMBRANE PROTEIN YEDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30574:SF1">
        <property type="entry name" value="SULPHUR TRANSPORT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04143">
        <property type="entry name" value="Sulf_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="259"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="321"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="137"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4040740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="347" mass="34758" checksum="300F133F9E495C94" modified="2024-10-02" version="1">MNNLFTGAAMGAALTTAGVYAPDIILSQFTFSDFTMLQTFLTAAAGSTLLVTAFQTLHLTTLPPRTPSSLGLLSTRYDGNILGGALLGAGMAVSGACPGTVLAQLGVGVASGRYALGGAVLAGVAWSWVVRNRPMSCAGTSSSGSGSGSGDGKGEERGEGKLEGAKEGKEGRSETVYDALGVSRGALLVGLEAVLILAIVAAVRYTDASAAEARGIPPYFAGLAIAAAQLVSMVLRGSLLGASTAFEELGGWVWGTRKYANVLFSVGMVGGAWLISQAVPALRPVTEVAISPARSALGGFMIVFGSRMAGGCTSGHGISGLSLMSISSFLTAAATFGAGGLTGLWMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PJA5</accession>
    <name>A0AAN6PJA5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="6">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_44919</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 6">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PPP phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="6"/>
    <dbReference type="EMBL" id="MU854347">
        <property type="protein sequence ID" value="KAK4042033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PJA5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033096">
        <property type="entry name" value="PPPtase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="8">
        <location>
            <begin position="201"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="123"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="131"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR033096-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4042033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="404" mass="44197" checksum="371E5D7A38C0EF16" modified="2024-10-02" version="1">MANVPKPGPANLRPGAGLDEWLDEAKQCHYLPEHVMKQLCEMVKEVLMEESNIQPVVTPVTICGDIHGQFYDLLELFRVAGGMPGESNVQAPMTSTTVITSDDIEPPSVITNPKLKSMVRNAGATAGEGGAGDDNDNDDTIAEAHEESTPHAAPPADAGVQSADTRFVFLGDFVDRGYFSLETFTLLMCLKAKYPDRIVLVRGNHESRQITQVYGFYEECQQKYGNASVWKACCQVFDFLVLAAIVDGTVLCVHGGLSPEIRTIDQIRVVARAQEIPHEGAFCDLVWSDPEDIETWAISPRGAGWLFGHKVATEFNHVNGLKTIARAHQLVNEGYKFHFAEKSVVTVWSAPNYCYRCGNVASIMTVASADGNLDASTRFSIFSAVPDDQRHIPGGRRGAGDYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PJB5</accession>
    <name>A0AAN6PJB5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_33935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854347">
        <property type="protein sequence ID" value="KAK4042048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PJB5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4042048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="272" mass="28713" checksum="AB3BB1892C41005A" modified="2024-10-02" version="1">MPSIASSIPPSSSSSILALSTPFVQPATCTNIFSTSILTATVRSTNIISGSTSRFAFSPAVCPSGWTAYNLGTDGPVSTADCCARYNYLPPTSYLTSCLLALVRSSGYSAARPSWATGIDGLQTGTPGCFKRVTAPRASGVLDTFPGPVDVQAHNAYHVSWQASDTAMLTPQPPAITCPYGIDMWVPGSPVTSKACDSTWVNDTGISPRVAEFVTIGVPIIVCVVVFGLVGCYCYAYRKGKREQQIRAAARARAAREQNERDYSAPASVDQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PJK2</accession>
    <name>A0AAN6PJK2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Probable aspartate--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">C8A01DRAFT_14363</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>tRNA(Asp) + L-aspartate + ATP = L-aspartyl-tRNA(Asp) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19649"/>
            <dbReference type="Rhea" id="RHEA-COMP:9660"/>
            <dbReference type="Rhea" id="RHEA-COMP:9678"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.12" evidence="3"/>
    <dbReference type="EMBL" id="MU854348">
        <property type="protein sequence ID" value="KAK4041957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PJK2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04320">
        <property type="entry name" value="AspRS_cyto_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00776">
        <property type="entry name" value="AsxRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000038">
        <property type="entry name" value="Aspartate--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02075">
        <property type="entry name" value="Asp_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004523">
        <property type="entry name" value="Asp-tRNA_synthase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450:SF1">
        <property type="entry name" value="ASPARTATE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450">
        <property type="entry name" value="ASPARTYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="13">
        <location>
            <begin position="271"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="56"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00070516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK4041957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="583" mass="64092" checksum="4EEB2175E7527B11" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PJK9</accession>
    <name>A0AAN6PJK9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial division protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">C8A01DRAFT_45601</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in mitochondrial fission. Acts as an adapter protein required to form mitochondrial fission complexes. Formation of these complexes is required to promote constriction and fission of the mitochondrial compartment at a late step in mitochondrial division.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the WD repeat MDV1/CAF4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854362">
        <property type="protein sequence ID" value="KAK4041160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PJK9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd22881">
        <property type="entry name" value="Mdv1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000404">
        <property type="entry name" value="Mitochondrial division protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000881">
        <property type="entry name" value="Mitochondrial division protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855:SF28">
        <property type="entry name" value="CCR4-ASSOCIATED FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855">
        <property type="entry name" value="WD40 REPEAT PROTEIN 12, 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="314"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="356"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="434"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="517"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="540"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="133"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="243"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="253"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="269"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="286"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00043913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK4041160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="659" mass="73132" checksum="FFFF09DE64443469" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PJN1</accession>
    <name>A0AAN6PJN1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_15734</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854378">
        <property type="protein sequence ID" value="KAK4040366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PJN1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4040366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="62" mass="6241" checksum="1CD758EE47A17F88" modified="2024-10-02" version="1">MSAAQALAHTITLRSGATQIWGSLGPGIFSLFAATRGSAQHSTGFRCILAQALSSEGGLPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PJY5</accession>
    <name>A0AAN6PJY5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">glutathione-specific gamma-glutamylcyclotransferase</fullName>
            <ecNumber evidence="1">4.3.2.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_14267</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.7" evidence="1"/>
    <dbReference type="EMBL" id="MU854346">
        <property type="protein sequence ID" value="KAK4042072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PJY5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061928">
        <property type="term" value="F:glutathione specific gamma-glutamylcyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.490.10:FF:000021">
        <property type="entry name" value="Gamma-glutamylcyclotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006840">
        <property type="entry name" value="ChaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12192">
        <property type="entry name" value="CATION TRANSPORT PROTEIN CHAC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12192:SF2">
        <property type="entry name" value="GLUTATHIONE-SPECIFIC GAMMA-GLUTAMYLCYCLOTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04752">
        <property type="entry name" value="ChaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="209"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="239"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="257"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="277"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4042072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="286" mass="32562" checksum="49970B174A8E9A91" modified="2024-10-02" version="1">MSVDGTAPEADEFWLFGYGSLIWKPPPHFDRRIPGWVTGYVRRFWQDHRGTPEAPGRVVTLISRSYWEQLTDHHDSAPDRVWGVAYRIKPDRVAEVKEYLDIREINGYTIHYTPFHPAPAPDGLTQHHRRDHRHPIRTLVYIGTPDNDQFVGPQDPQELAEHIYRSAGPSGPNRDYLWGLEAALDELSPESGDEHVTDLSNRLRAVAAREEEKKKEEEEAEEGVVAAGRGEKTIPRPASPVSGVSVAVGPDQPSSVLRREQQHHEQHHDFRKVSSIDEQEETEKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PK73</accession>
    <name>A0AAN6PK73_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">C8A01DRAFT_44522</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854340">
        <property type="protein sequence ID" value="KAK4042513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PK73"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000060">
        <property type="entry name" value="zinc finger protein 436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000176">
        <property type="entry name" value="zinc finger protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF49">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="262"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="290"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="17"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="312"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="50"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="319"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK4042513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="337" mass="36396" checksum="59C2D973AC9276AD" modified="2024-10-02" version="1">MASTMVTTHYAHAPQQSLHYGYMPPPSPPMDETAKCSLPSISNLLGLADQGSPTSETSPQSQQQQQQQQQCMSSSWWDMGLPGTNSTPAQISKPETRPNSSHYGNPALLRSGLPPSPPMSSDASFEGFNSPSTRSVSQVPNGSNYYFESTPPLQMEADARQMAATAAVPRVSVQASAYQPQFAGPAYMSQPAMTSYYPPIQAAAPPQTQMSGLYYQRALPQSFPPPLPMSVTLAPTAGNPWQHHHYIAPSASASFPQSQDRYICQTCNKAFSRPSSLRIHSHSHTGEKPFKCPFPGCGKAFSVRSNMKRHERGCHNYDSSSTTSSSTTASSSNGSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PKC0</accession>
    <name>A0AAN6PKC0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_45997</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ELP6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854371">
        <property type="protein sequence ID" value="KAK4040711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PKC0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19495">
        <property type="entry name" value="Elp6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018627">
        <property type="entry name" value="ELP6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16184">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16184:SF6">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09807">
        <property type="entry name" value="ELP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="48"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="126"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="132"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4040711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="319" mass="34622" checksum="FB827433D4711F3A" modified="2024-10-02" version="1">MTSRIPHLLEPYLPHLPQEATLVVLTSVLGASTNWLVLRHLHALLKPSSASQNKNKNKKPTPLSEGGRQAENEHDDEQQEEVAVLLLSFLRDLPFWRENLSRLGIDLEAAARRGRFGFVDGLGGLFSPGNGQQPQSQQQQPQSQPQQPWNRALTSAAPGDIGRVVLEGVEQLKTGSSSTAGEGRERKVVLVIDGLDFVLAALDPRLGQGAGDSSGAAAVMKDMLMELREKTHAAIVTLAADDPLIKEQETTLEKQHAWFALSLAHEADMVLSLRLLDTGAAKDVSGVIRITHGGARAKDHEYLYHVGGDGGVRVFERGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PKH1</accession>
    <name>A0AAN6PKH1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">IMP-specific 5'-nucleotidase 1</fullName>
            <ecNumber evidence="4">3.1.3.99</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">C8A01DRAFT_35252</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>IMP + H2O = inosine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:27718"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="3.1.3.99"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ISN1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.99" evidence="4"/>
    <dbReference type="EMBL" id="MU854371">
        <property type="protein sequence ID" value="KAK4040694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PKH1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008253">
        <property type="term" value="F:5'-nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006190">
        <property type="term" value="P:inosine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071590">
        <property type="term" value="P:nicotinamide riboside biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071592">
        <property type="term" value="P:nicotinic acid riboside biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009453">
        <property type="entry name" value="ISN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28213">
        <property type="entry name" value="IMP-SPECIFIC 5'-NUCLEOTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28213:SF1">
        <property type="entry name" value="IMP-SPECIFIC 5'-NUCLEOTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06437">
        <property type="entry name" value="ISN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042928447" description="IMP-specific 5'-nucleotidase 1" evidence="14">
        <location>
            <begin position="18"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="92"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="93"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK4040694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="615" mass="66838" checksum="6C3A529447D184DD" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PLE5</accession>
    <name>A0AAN6PLE5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DRBM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_32684</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854330">
        <property type="protein sequence ID" value="KAK4043194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PLE5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="184"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4043194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="304" mass="33363" checksum="46373243F7A24F2E" modified="2024-10-02" version="1">MAHSAQIAVGSSTLDEPVNYRDLKSWIEEQERNPTPLSPLQQRAISDLRRSLEPKVDDRDWVSLLNLYNQAHGGISDFKDHPAADNRWINWCHFELAPDAEQLTFPNPEAGFTINEAGALAAPCFGRKKDAKQYAAKCCIEWLMKGGYMPSDGVSVEFAKGKARPVLPTAKQTPTTNPPPPNQPITTTTVSQPTTTTTTTAHDDDDPPATKRVEDLCRLIGLAIPQYKIAPVDSPSLSGTQFFDGRADFGVDAIKVPDGLGKVANVYGRKNARERVAEEVLVWLVGEERKRVAEAEEMLAQIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PLJ8</accession>
    <name>A0AAN6PLJ8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Snf7 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_44659</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854343">
        <property type="protein sequence ID" value="KAK4042270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PLJ8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000815">
        <property type="term" value="C:ESCRT III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1060">
        <property type="entry name" value="ESAT-6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF5">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="168"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4042270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="209" mass="23201" checksum="4F8C2549EF8801E3" modified="2024-10-02" version="1">MGNSSSRITAQDQAILDLKIQRDKLQQYQRRITHLTDRETAAARQLLAKGDKPRALLALRRKKYQESLLAKTDAQLEQLERLTSSVEFALIQKDVLFGLQQGTRVLGEIHAEMGGIENVEKLMGETEEAIAYQREVSEIIAGRISVQDEEEVEDELAALEAEVAKKKEGVQRLPSVPDTQLPEQAEVAEEAGAEAAGPRAQTERQAMLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PMJ3</accession>
    <name>A0AAN6PMJ3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_14662</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854354">
        <property type="protein sequence ID" value="KAK4041596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PMJ3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF37">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="34"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4041596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="403" mass="44632" checksum="3FA9835F2D63855A" modified="2024-10-02" version="1">MASNSPISPGAVLALGSALRNDGSWPMLCFGTDCSPFQSGWSQVYALRFPDDREVSWAFHVPAQTGPSLTPKTVAAVVESEASMLAKLDESGFRWSPKLIHYDAGHDNLIKRPYLVMSWVHGKSLEWTNSAPKPQHREKILRQIMGIQLELAERTKVSRPGASTLTFLTTVVDGKVMNAAREVDKEPAPGVRDCLIHRALLRYVIHKTLEFEPSIFSVSHGNLAAENIIVDSDYNITGIVGWSSARALPLQLAFRLPRFLATKPDSPNQLAPQLPDDLPAFAKQYLQPSPTLMADRHFVRLYLASLAADHDQGERASLAQAMKHVLSDLDVNWQYLIIEACFSKGLQAWLADRGWLLLGTKGHMASLADFPPEKIMHEAEEFLREKGTGDDSLREAILKACDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PMS6</accession>
    <name>A0AAN6PMS6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Mediator of RNA polymerase II transcription subunit 31</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">C8A01DRAFT_14335</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 10">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Mediator complex subunit 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854348">
        <property type="protein sequence ID" value="KAK4041999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PMS6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1340:FF:000002">
        <property type="entry name" value="Mediator of RNA polymerase II transcription subunit 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1340">
        <property type="entry name" value="Mediator of RNA polymerase II, submodule Med31 (Soh1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038089">
        <property type="entry name" value="Med31_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008831">
        <property type="entry name" value="Mediator_Med31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13186">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05669">
        <property type="entry name" value="Med31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0010">Activator</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK4041999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="129" mass="14833" checksum="EF0618FB4697ADD0" modified="2024-10-02" version="1">MESGPMSVDSAALDPPALPEDGANEPKYGGHSRFELELEFVQSLANPQYLNYLASRKFLTNPAFVAYLEYLQYWTRPPYLKYLTFPTSTLKMLELLQQEKFRQDIISPDLAHAMIMEGMKTAVEWHREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PMV2</accession>
    <name>A0AAN6PMV2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_12795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854325">
        <property type="protein sequence ID" value="KAK4043677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PMV2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043037561" evidence="1">
        <location>
            <begin position="18"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4043677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="220" mass="22739" checksum="A37217B1436F742D" modified="2024-10-02" version="1">MKVRAIGILCLISGVLALPLEQAQHSQQVEPQQAAPAEAPEPFFDLEMMMGQGMMHRIMTGNVDTEAFQQMVNQVQHQVEAINQLVKEHGSDTNGLMEALVSPMSQLNQTLAVGVHRLAFNPAGNTVNTVSRLPAVKPLTLLSDLLRTVSNLLENILTRGPIGGLLNGLLGGILTGVADTVGGVVGGGPAAQVPDLLAGILGSIGTVVPGAGAGVGIKLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PN88</accession>
    <name>A0AAN6PN88_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_31781</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854321">
        <property type="protein sequence ID" value="KAK4044178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PN88"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000117">
        <property type="entry name" value="MFS hexose transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF29">
        <property type="entry name" value="SUGAR TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14500)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="329"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="379"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="424"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="454"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="39"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4044178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="528" mass="59564" checksum="0EBC0DE4961B4530" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PNF8</accession>
    <name>A0AAN6PNF8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Prokaryotic-type class I peptide chain release factors domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_44001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854332">
        <property type="protein sequence ID" value="KAK4043078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PNF8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000070">
        <property type="entry name" value="Related to MRF1-peptide chain release factor, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050057">
        <property type="entry name" value="Prokaryotic/Mito_RF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43804">
        <property type="entry name" value="LD18447P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43804:SF7">
        <property type="entry name" value="LD18447P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="Release factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prokaryotic-type class I peptide chain release factors" evidence="5">
        <location>
            <begin position="279"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="75"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4043078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="426" mass="47090" checksum="E3E37B3BDB435BBB" modified="2024-10-02" version="1">MLAAPWVCRSCVRSLRRAGVSQFIRRASTETTIKLPPALLERARKLTAEHDQLTAALENDFDAKKAKRAGEISRVADALRQLEKAKGALSELQGLLESNDAELRELARDDLEATNAQLAGSSHNLSVALTPKHPFADMPCLLEIRPGPGGTEGRFFADSLFHMYKAYCASKGYRTRVVQYEASDSDGSTGSDGEIPLQEAVLEVQEPGAYGLFRGEAGMHRVQRVPATEKSGRTHTSAVAVWVLPSFPENGTSESEADWDKPESDFYIDPSEVRSEKMRAGGAGGQHVNKTESAIRLTHIPTGTTVSMQDSRSQHRNREDAWRLLRSRLAQQRREAREETARQLRSSVLANSQITRGDKIRTYQYQQDRCTDHRSGLNAHNLPDVLRGGETLGRVMESVQTWLINKDIQALIADEEAAATTAKKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PNK7</accession>
    <name>A0AAN6PNK7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ribosome assembly protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_42783</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854319">
        <property type="protein sequence ID" value="KAK4044343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PNK7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF0">
        <property type="entry name" value="NOTCHLESS PROTEIN HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="340"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="383"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="426"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="474"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="598"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="640"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="682"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="98"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="147"/>
            <end position="225"/>
        </location>
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        <location>
            <begin position="162"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="180"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4044343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="715" mass="80204" checksum="FADD4F7D58987B1B" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PNL5</accession>
    <name>A0AAN6PNL5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_42946</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854320">
        <property type="protein sequence ID" value="KAK4044276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PNL5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="2"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4044276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="630" mass="69541" checksum="779C849F6565AD38" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PP39</accession>
    <name>A0AAN6PP39_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_43392</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854325">
        <property type="protein sequence ID" value="KAK4043635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PP39"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF6">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="94"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4043635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="463" mass="51607" checksum="7D4DDEA76C43E4F8" modified="2024-10-02" version="1">MSAVPSASSDAVAADRNEPGSGRGEGSSSTSAEQQRRASTSRTLDDVMREPSRTVPDVVVLDSLPDTAGRKDVLDPKEDLWLSTVDGRYSSPIIPLHVGEPPYHETFYVHKHVLLKSEYFEKALCGEFSESGSQSINLPEENPAIFHFLIAYLYEGRYEPIRPAASVLVPDQDKGKGNAADTGADSDSDSVSSLESDVSARSRHRRDRHRRREDRNWERMRQKHPGMHRPNCNCPQCAAASGPPCWSCRAPRNPPPYHHHHHTVYIHDGRPERQPRRPPRRRHHNNGVPPPPLTPPLPAPPGGAAPPGRGTPSWQQPDPNGGRIAGEDLRTWLLAYELNLDVYILANKFLLDGFKKEIARAAVDMLETAGSDAAVVEVLYLCRKLYDGLPETDPLLKMVFARVGFLQPWRSAERETGEFMMGNPEIAPLLLREMAARREDDVNGRALPSMVRPWIPAAEMWPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PP50</accession>
    <name>A0AAN6PP50_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_43408</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854325">
        <property type="protein sequence ID" value="KAK4043650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PP50"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37849">
        <property type="entry name" value="YALI0E11605P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37849:SF1">
        <property type="entry name" value="YALI0E11605P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4043650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="118" mass="12734" checksum="577F72FD46838294" modified="2024-10-02" version="1">MASRILSHGARALTRTAAPARMFNTSAARLDAAVAAGVPPTPLPARRPIGALRGGLFGFFLGSSLAAGGVYYYAIQEYKASNELLTEDIYALQNAVERLSQYVTTLEDKMEALERKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PP52</accession>
    <name>A0AAN6PP52_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquitin-related domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_31365</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854318">
        <property type="protein sequence ID" value="KAK4044576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PP52"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd16116">
        <property type="entry name" value="Ubl_Smt3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000155">
        <property type="entry name" value="Ubiquitin-like protein SMT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022617">
        <property type="entry name" value="Rad60/SUMO-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10562">
        <property type="entry name" value="SMALL UBIQUITIN-RELATED MODIFIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11976">
        <property type="entry name" value="Rad60-SLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="23"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4044576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="100" mass="10964" checksum="1D396561E7F28105" modified="2024-10-02" version="1">MADNAENGSPVPPGGDMAPAASEHLNIKVTDNNNEVFFKIKRSTKLEKLMTAFCERQGKTPASVRFLFEGQRVQPTDTPDTLEMQDGDTLEVHQEQVGGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PPW9</accession>
    <name>A0AAN6PPW9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alpha/beta-hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_13307</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854331">
        <property type="protein sequence ID" value="KAK4043094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PPW9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4043094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="494" mass="54086" checksum="E03686701E53B43E" modified="2024-10-02" version="1">MSPWLRFTRAPSLRCVVVQPRKFHPRLLSTHSSAEHVRVPCASAGAITVSLHNIAHHDTGSPLVILIPPFSQPGPNPITPVPSCFHDYPTAVINYRWQPQDGDERPEYPLHWPTPLHDVNFGYSWIMDNLGSGIDPSTEPRPAYVYGSYLGASLAAGLALTESHVPARSQPMTIRGLMAHNGIYNWTMFLPDHPIHKLKAKPNSNRKKRGLQLPFAATTLNDDNPIEEEGIFTDLKHLTPDLFADPSNLFDPFASACLFFHSANLHVPDDFTTPLSATSPSSALTADFTAAIDALANHSSPSSPEGGEEEDTETAATLLTRAAHLAKQQKPPRKGYLVFPPRNNSTLRLPATLLIHSQPQPATPQSRTGRSSKSRNSFAVQASELAGLMLRSLDMHEFRSPRRGSGPAPWEWEAEETVVDGGDSAAQEEWERWRGIERRVQSLEVEAPSGGQGGERGLGLGLDEKAGEVVGEWLRERIDGDFGDFGGEGEAEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PSP7</accession>
    <name>A0AAN6PSP7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_31779</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FMO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854321">
        <property type="protein sequence ID" value="KAK4044176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PSP7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000258">
        <property type="entry name" value="Flavin-binding monooxygenase-like protein (AFU_orthologue AFUA_6G01900)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="503"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="503"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4044176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="618" mass="68676" checksum="F98AD303192AFD1F" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SJY9</accession>
    <name>A0AAN6SJY9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_21596</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU855126">
        <property type="protein sequence ID" value="KAK4031151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SJY9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4031151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="184" mass="20655" checksum="0D64ADF6CD475FC0" modified="2024-10-02" version="1" fragment="single">ASIGAYIDDRTSHIKCPRHDPFLQDHVRQVLRQKADGTFLWVALVLQELGQAKPWAMRRVVDDIPKGLDELYGRMIEQLQQLREEDREYCQLVLATATLACRPLRLPELGAVSGLPGEISGEAEWMQQIVTMSGSLLTVRDETVYFVHQSAKEYLIGKAASIIIPCGPAAAHWSIFQRSLDARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SKV1</accession>
    <name>A0AAN6SKV1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glucanase</fullName>
            <ecNumber evidence="9">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_41428</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="9">Belongs to the glycosyl hydrolase family 6.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="9"/>
    <dbReference type="EMBL" id="MU854645">
        <property type="protein sequence ID" value="KAK4032126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SKV1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.40">
        <property type="entry name" value="1, 4-beta cellobiohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016288">
        <property type="entry name" value="Beta_cellobiohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036434">
        <property type="entry name" value="Beta_cellobiohydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001524">
        <property type="entry name" value="Glyco_hydro_6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34876">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34876:SF10">
        <property type="entry name" value="GLUCANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01341">
        <property type="entry name" value="Glyco_hydro_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001100">
        <property type="entry name" value="Beta_cellobiohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00733">
        <property type="entry name" value="GLHYDRLASE6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51989">
        <property type="entry name" value="Glycosyl hydrolases family 6, cellulases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00656">
        <property type="entry name" value="GLYCOSYL_HYDROL_F6_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2 9" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="4 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 9 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042672304" description="Glucanase" evidence="9">
        <location>
            <begin position="19"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6 8">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="347"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001100-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001100-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4032126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="379" mass="40970" checksum="DDBB38ECA921A010" modified="2024-10-02" version="1">MRASCLLAALATGGLVSAAPSPKPTPPREGGDVNPFLGKAQFVNPKWAAKLDQTLRSFLWKGDIVNSLRTYKVQKTSSFVWVSKRADLSNIDDAIAAARKAQKQTGKKQIVGLVLYNLPDRDCSAGESAGELSSSENGLELYKTEFIKPYAEKVAAAKDVDFAIVLEPDSLANLVTNMGIELCANAAPVYREGIAHAIAELQQPNVHLYMDAAHGGWLGWDDNLPLAAKLFAEVVAQAGTDKKIRGFVTNVSNYNPFNAVVRENYTEWSHSWDESHYASSLAPHLEAAGLPSHFIVDQGRVHLPGARKEWGEWCNVQPAGFGPAPTTNTNNTVVDALVWVKPGGESDGQCGMAGATKAGEWFDEYAQMLVKNADPSVFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SKY2</accession>
    <name>A0AAN6SKY2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_51467</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854803">
        <property type="protein sequence ID" value="KAK4031454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SKY2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052427">
        <property type="entry name" value="Glycosyltrans_GT2/GT47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47844:SF1">
        <property type="entry name" value="EXOSTOSIN-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47844">
        <property type="entry name" value="SYNTHASE CPS1, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G02500)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13641">
        <property type="entry name" value="Glyco_tranf_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="188"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4031454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="317" mass="36972" checksum="F942FA160CF7EE2E" modified="2024-10-02" version="1">MIDTTIQRLGFLCSAGSWAVFHTLLWYSPSVATTLRILDSSPRVKITVLRVKKANKHLQVCKALEDGCVKTAITVLADNDVEWPSTLMPWLLALFEDDSIGGVGTCQRVKHVVHRDLATRIFNWLRAAYIERRNFEISATHNIGGGTSYMSRRTGLYEREYEIKTTLETNTKSNWRSNWTSLVYERHYIYTLYIATFTSLAFVWGMENWQPRNRRTLLRAEIAFMFGFTKVVKLVRLLRRNPRDIMFLPVSILFSYFYSLIKLYTLFTLKETSWGSRESGDEHNTFPLQEDTFPLQEEPVMYRYQFAFVLSKALTSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SL81</accession>
    <name>A0AAN6SL81_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_41770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854702">
        <property type="protein sequence ID" value="KAK4031784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SL81"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF55">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4031784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="198" mass="22065" checksum="5072EBD885D99071" modified="2024-10-02" version="1">MVVLGYQEKEGESLTPFYNLITTKSAQLKHSVKPWHKTTNGELASRLYDKERILNYAAALQLVSKKTTIPVPRLIGFGESDDGTAWIEIERTHGGHVEDGGECDECDRIARANGRRFIAEEVIPQLNSLTSDTTGLDGVVIPPLWVTFHDKTAHWPPKKSTSGQPEYVFCHGNLHGHSILMHAETLHVLKVVDWDEAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SL95</accession>
    <name>A0AAN6SL95_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">protein-ribulosamine 3-kinase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_20379</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>N(6)-D-ribulosyl-L-lysyl-[protein] + ATP = N(6)-(3-O-phospho-D-ribulosyl)-L-lysyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48432"/>
            <dbReference type="Rhea" id="RHEA-COMP:12103"/>
            <dbReference type="Rhea" id="RHEA-COMP:12104"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:90418"/>
            <dbReference type="ChEBI" id="CHEBI:90420"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.172"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:48433"/>
        </physiologicalReaction>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.172" evidence="1"/>
    <dbReference type="EMBL" id="MU854597">
        <property type="protein sequence ID" value="KAK4032546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SL95"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102193">
        <property type="term" value="F:protein-ribulosamine 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016477">
        <property type="entry name" value="Fructo-/Ketosamine-3-kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12149">
        <property type="entry name" value="FRUCTOSAMINE 3 KINASE-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12149:SF8">
        <property type="entry name" value="PROTEIN-RIBULOSAMINE 3-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03881">
        <property type="entry name" value="Fructosamin_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
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    </dbReference>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00048655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4032546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="365" mass="41779" checksum="891B2C0B4A72D12F" modified="2024-10-02" version="1">MTDKEVWDKEIPIPERLIKYVDQGVRDKLPPGTQVHGITQSGASYWARTAKIEAADAVGNPTPFFMKVLQFEQGKDMVSAEYYAMSLLHSANPDMVVEPVAWGAYTEEPETYFFVCRFHQFLKVKEPSGRKELPPVNKIPDVLVFPGLVSDLHKRGASRTGEFGFPITMYGGRNPQTFPLCKSWEECFSKGLSNIFDAEEQTHGPDEEMRHLREGLMTKVIPRLLRPLETEGRVLTPTLVHGDLWDGNVAVDKATGKPLVFDATPLYAHNEYELGPWWPTRHRMGRDYIEEYQTIHGASKPSRDFESRVKLYAIRFDLHASSLYPGNLLWRNLVKDAIRDLLNRYPLGYEGYLMEQERSRQTGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SLV2</accession>
    <name>A0AAN6SLV2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_41675</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854684">
        <property type="protein sequence ID" value="KAK4031890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SLV2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES SMC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90257">
        <property type="entry name" value="Myosin rod fragments"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="126"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="674"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="708"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="180"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="390"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="492"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="130"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="686"/>
            <end position="695"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4031890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="988" mass="110405" checksum="D0075E923D145216" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SLV3</accession>
    <name>A0AAN6SLV3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_20792</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854650">
        <property type="protein sequence ID" value="KAK4032098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SLV3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="175"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="447"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="482"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="563"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="24"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="56"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="200"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="213"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="280"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="299"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="346"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="372"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="447"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="485"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4032098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="759" mass="81895" checksum="669BA6B4D28145BB" modified="2024-10-02" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SM23</accession>
    <name>A0AAN6SM23_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein CFT1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Cleavage factor two protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Protein cft1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">C8A01DRAFT_40926</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the CFT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854589">
        <property type="protein sequence ID" value="KAK4032624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000788">
        <property type="entry name" value="mRNA cleavage and polyadenylation factor subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018846">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058543">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050358">
        <property type="entry name" value="RSE1/DDB1/CFT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004871">
        <property type="entry name" value="RSE1/DDB1/CPSF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10644">
        <property type="entry name" value="DNA REPAIR/RNA PROCESSING CPSF FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10433">
        <property type="entry name" value="Beta-prop_RSE1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23726">
        <property type="entry name" value="Beta-prop_RSE1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03178">
        <property type="entry name" value="CPSF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RSE1/DDB1/CPSF1 first beta-propeller" evidence="11">
        <location>
            <begin position="95"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 second beta-propeller" evidence="12">
        <location>
            <begin position="584"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 C-terminal" evidence="10">
        <location>
            <begin position="1061"/>
            <end position="1414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="468"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1296"/>
            <end position="1334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="477"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF10433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF23726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK4032624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1452" mass="156903" checksum="833908C3C901E378" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SM33</accession>
    <name>A0AAN6SM33_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyltransferase 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_19626</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854531">
        <property type="protein sequence ID" value="KAK4033416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SM33"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050879">
        <property type="entry name" value="Acyltransferase_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028">
        <property type="entry name" value="ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028:SF134">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08520)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="372"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="Acyltransferase 3" evidence="2">
        <location>
            <begin position="21"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4033416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="412" mass="46322" checksum="78B480E3F2039354" modified="2024-10-02" version="1" fragment="single">YLYTSFAIAPGYGTSHAHHHLPLLPFIRLLFSGPPMVCLFFVVSGYALSLKPLRLMHARDWETLNKTMASFIFRRGIRLFLPTAASTAVVVGLVWAGAYEWTREFANDERFLRNVRETHFDGGDGVTLGELGWAWAGGMFRFVHVWDWAPFGGSTGLDVHLWTVPVEFRCSMGLFLTVLGTGRLRRGWRLGVVGGLVVFVYMSQRWEMVLFYAGMVLAEMDVVRGAHGSAAGAAPALSRASSPSPQPARRWTTKRAAWAALSVVGLYLMSQPDERGAETPGWVLLTRLIPEWWQDEHRYWQSAGAILFVFAVGRSRGWQRFFTLPVVQYFGRISYALYLMHGPVMHTVGYAIERWAWGLTGTEGRAYEAGFALAAVFVVPIVIWVSDVFWRAVDAPVVRFAKWLEARCSISE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SM57</accession>
    <name>A0AAN6SM57_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription factor/nuclear export subunit protein 2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_41160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854614">
        <property type="protein sequence ID" value="KAK4032398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SM57"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040007">
        <property type="entry name" value="Tho2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021418">
        <property type="entry name" value="THO_THOC2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21597:SF0">
        <property type="entry name" value="THO COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21597">
        <property type="entry name" value="THO2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11262">
        <property type="entry name" value="Tho2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THO complex subunitTHOC2 C-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4032398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="284" mass="32315" checksum="1140F1723CBF9B40" modified="2024-10-02" version="1">MLLYDRLFNHNRLRAIIFTCTVREAEHLARFLKLILGGLSKWHGDKTAYEKEALGLKDLQGNKTRQYLGFATAFDADGKPTEFIEHDPFRELLFRWHKELNTALRSCLNGMEWMHIRNAITVLKGVIDFFPAINFMADKFLEQLKTITEREAASKNAPESEHGHRVDLSVTAQTIYSELQKRKSKWILVQAFRPGLPKREAKDEARVAPANSSLRASAAEFKPNASKRHKRCGLEAGPANHEYGTSDHTKTCLYPRLDSRAPTRATQVLNPPKWQGAGECWEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SMS3</accession>
    <name>A0AAN6SMS3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ER lumen protein retaining receptor-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">C8A01DRAFT_39365</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854492">
        <property type="protein sequence ID" value="KAK4034151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SMS3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046923">
        <property type="term" value="F:ER retention sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006621">
        <property type="term" value="P:protein retention in ER lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000133">
        <property type="entry name" value="ER_ret_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10585">
        <property type="entry name" value="ER LUMEN PROTEIN RETAINING RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00810">
        <property type="entry name" value="ER_lumen_recept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00660">
        <property type="entry name" value="ERLUMENR"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="245"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="307"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="268"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="308"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="329"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="361"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK4034151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="389" mass="44244" checksum="8B35386C4F15AF6F" modified="2024-10-02" version="1">MWTIFRIAADMSHITAKCILVFSIHRNRSSEGVSLLTQLFYALVFVTRYTDLFRESYAWNYFFKVFYLLSSFYTIAIMRFVYPRTREREVAWKLSALILAGCLILSPFVMLIFDPSDWWSFQEYLWVFSQVLESLCVLPQLLLLRQTTIPTVITSFYIVFLGSYRGLYLLNWILKELDTNMKKPNPISVIFGVIQTALYLDFGWVYWSRQRVKLRNGGVVDADDLSRGWLLRRIFGNKQFARDIDGSHNETDDEESAPALHNGFNHHQGGGSNNNGGGGVRPKWGSRGISISADEGVLEHERARGQALDDDGGYDDDDEEHGVTNVVDPDAKMRDPDELARALDEEEDLDAAPGGSSSQQKKKEEEGGLHPDARGEPSGVRNGDEWNDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SNM5</accession>
    <name>A0AAN6SNM5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PLAC8 family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_49696</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854510">
        <property type="protein sequence ID" value="KAK4033780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SNM5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006461">
        <property type="entry name" value="PLAC_motif_containing"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01571">
        <property type="entry name" value="A_thal_Cys_rich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15907">
        <property type="entry name" value="DUF614 FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04749">
        <property type="entry name" value="PLAC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4033780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="177" mass="19340" checksum="5977391A9CE00A24" modified="2024-10-02" version="1">MAAPQQQQPAAAGPINNDDIADWTARLNDVLARPGEYVNSKSPANAQPWYSSFFGCFAPIDTCLMAWCCPCVVFGRTHHRTRKNANLEGYEPINTSCLVFCASGCVGCHWVPMAMQRADLRTKHNLEGSCLLDIATACCCGCCQLVQADKEAAHREPLLVQQQGYQAQGGMQFPAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SNQ2</accession>
    <name>A0AAN6SNQ2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1761 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_39678</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854506">
        <property type="protein sequence ID" value="KAK4033870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SNQ2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013879">
        <property type="entry name" value="DUF1761"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40638">
        <property type="entry name" value="UPF0591 MEMBRANE PROTEIN C15E1.02C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40638:SF1">
        <property type="entry name" value="UPF0591 MEMBRANE PROTEIN C15E1.02C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08570">
        <property type="entry name" value="DUF1761"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4033870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="167" mass="17677" checksum="5DD4371D7B537B1C" modified="2024-10-02" version="1">MSLHYLPAVKPSAIALGTIFNHTAELAVLSPLFGQTYQRAKAANTKEEFLRSREATGAAVAYGTALVGSALQSYGVGALINATGTLSYKGAAYLGGLIFAATSAPTFFSQLFVEKRALEQVGVSILAKLFETVGLSVFMTWWGTRTNPFENTGAGGTPLSRNSFRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SNX2</accession>
    <name>A0AAN6SNX2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_18603</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854472">
        <property type="protein sequence ID" value="KAK4034619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SNX2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="27"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="60"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="93"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="126"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="159"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="192"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="225"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="258"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="291"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="324"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="385"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="392"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4034619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="425" mass="44821" checksum="6DA58F8F5D4FB8B2" modified="2024-10-02" version="1">MAAAQGDSAAVQRFLGHVKPDKPRDAEGFTALHRATINGHLDVVRRLLAANAWPSPRDNKGRAPLHWAARRGYLEILQEFVKIGVSITLRDRKGRTPLHTAADGGHLEVVAYLLQRGAVVDVRDEHELTPLIRAAGAGYESVVWLLLKNGADVEERTDPGFTALHSAASAGHDAVVDVLLEGKATIDGIDARGKTALIWAAQEGFVKTVKLLLAKGANVMARDRDGCTALHVAAAEGRDAVVELLLENGAGIETTDKRGHTALFFAADMGNGGMVRLLLSLGAFVNARGKHGGTALHLAAAIGEDVAVVALLEGGVDLDAKDAEGGTALHFAAANGHLSTVRLLLDKHANVHAIDGVGLTPAQVATRARVSSLLRGWAVSAERNRRGGVSGVEDKPLEDQRRNIQAEGAGPTMVLASRGPETQQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SP38</accession>
    <name>A0AAN6SP38_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_39218</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854485">
        <property type="protein sequence ID" value="KAK4034290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SP38"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042934654" evidence="1">
        <location>
            <begin position="21"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4034290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="76" mass="7591" checksum="5FC4E6F36F335137" modified="2024-10-02" version="1">MKLFILTSLSILLAAAPATAAPRPGTALQLPKEVEATELGARGTCSGGTGICSGGQCTCQGICDTGICPWYPCGSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SP92</accession>
    <name>A0AAN6SP92_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">N-alpha-acetyltransferase 40</fullName>
            <ecNumber evidence="4">2.3.1.257</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">C8A01DRAFT_38003</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N-terminal L-seryl-[histone H2A] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-seryl-[histone H2A] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50600"/>
            <dbReference type="Rhea" id="RHEA-COMP:12742"/>
            <dbReference type="Rhea" id="RHEA-COMP:12744"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64738"/>
            <dbReference type="ChEBI" id="CHEBI:83690"/>
            <dbReference type="EC" id="2.3.1.257"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>N-terminal L-seryl-[histone H4] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-seryl-[histone H4] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50596"/>
            <dbReference type="Rhea" id="RHEA-COMP:12740"/>
            <dbReference type="Rhea" id="RHEA-COMP:12743"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64738"/>
            <dbReference type="ChEBI" id="CHEBI:83690"/>
            <dbReference type="EC" id="2.3.1.257"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. NAA40 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.257" evidence="4"/>
    <dbReference type="EMBL" id="MU854441">
        <property type="protein sequence ID" value="KAK4038044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SP92"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043998">
        <property type="term" value="F:histone H2A acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010485">
        <property type="term" value="F:histone H4 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990189">
        <property type="term" value="F:protein N-terminal-serine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039949">
        <property type="entry name" value="NAA40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20531">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20531:SF1">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="12">
        <location>
            <begin position="51"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK4038044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="232" mass="26574" checksum="AE22B768ACD9DA21" modified="2024-10-02" version="1">MKPTTSPLELANRKTDEDFIADYLQPRSDEKPWVTAWTHPRTGAEYTVDLVRAENLSEDELMACFRLIEQTSRADYENSTFKWHPEKKVKEMRSTGLRYILVKEKGTMAIRGFTSLMPTYEEGEPVVYCYEIHLQPDLQGTGLGALFMGFHSTVAANLPPIKKVMLTCFLANQRGLEFYTKLGFERDEISPVPRKLRYGKIFTPDYVILSKPVRSVLDSKGVLTELRPDAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SPA0</accession>
    <name>A0AAN6SPA0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_48680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854456">
        <property type="protein sequence ID" value="KAK4035069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SPA0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4035069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="374" mass="41978" checksum="0B845DEF2F491E62" modified="2024-10-02" version="1">MPTTQTPTPHLPLPRDITTDILTRSLSCPPACALALLCPDWSLCRRRNPALEAVLRTTRVDTYTLPLDSTKEKGIISTTFDHAEADHIGLGLPCMRDPREKYGPRSGMPRDLRRELVRRWVGGSVVAVSQREEPMRVGPLWGVDLEGMGEGVALLREERAVGLLPYEDDLVVLGRTGRVAVCGVDWREKEALPPSLEGGEGEYLYERMRHLVVNSVLGLAEVEAEELGLLPGTWCAQTRRNLLYLQDRLEYERVAHLRLRWGALERLETLALDLRGYSLPTHGYFYDADVVELARSLQGKGLKLLVIAGLRSWRFYPGFEPADIAEAEGGKWDPTLAAWVSEKRGRGINWFKMFKGALRPGGRLVFVDKSNGKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SPA9</accession>
    <name>A0AAN6SPA9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Amine oxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_48266</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854440">
        <property type="protein sequence ID" value="KAK4038089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SPA9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050464">
        <property type="entry name" value="Zeta_carotene_desat/Oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923:SF26">
        <property type="entry name" value="FMN REDUCTASE LOT6, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G06600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042838299" description="Amine oxidase domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4038089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="475" mass="51279" checksum="21E990D134C9928B" modified="2024-10-02" version="1">MTSTLRLAGGLLAAASAVSATSWLPDIITRDVVIIGGGASGAYAAIRLKEDFQKSVVVVEKAGRMGGHVSTYDDPKTGQPFDFGVQSFNDYGPARAFFERMGVPVGSAPRVALTSQYADFSSGAAVDFTPPANADRVAALGRFLNATAAYEQYFLPGYWNFPAPGKIPEDLLLPFGQFVEKYQLHAAVNQVFQITGMGTGDMMNALTLYVLGAFGQPMIRAFLGQGATFTPTTHRNIALYEAVQSRLGADVLLNTVVSQSLRTSLGHTLWTTSASGKNTIILARRLLMAIEPTEANMAPFGLDLVEQSALSKFRYSSVHAGIVSHPSLPRNVSIVNTPRAASPANYVALPKPNLNVRFDYMGGGSDLFRVLMVGDAAFSKEKAQALVREDFARLVGAGTLPKTADPAKELEFRAWADHGAMHMNVAASELRSGFIQKLYALQGRRDTWWTGGAFSVQFQAILWAFDDVLLPKMFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SQ67</accession>
    <name>A0AAN6SQ67_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_38044</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854442">
        <property type="protein sequence ID" value="KAK4038018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SQ67"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042835463" evidence="2">
        <location>
            <begin position="18"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="187"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4038018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="242" mass="23680" checksum="23B3815473A9EE1F" modified="2024-10-02" version="1">MKTTSVLLLASAALASAQVKYEDGKYVCEQENASYCAGDSLGTDIIIRCNGKVGQPGRCSDNLAGQPPLGNHPALCYQTSPTAGDAACEKNCVVYPAAGNPFTLPADICTPTGTGAEPTTTITFIDPAPSSSTASGEPTTTITFIHPAPSSSSGEPTTTLTSIHPAPSSSGGGGKPSTVTTALVNPSQSHAGSSSSPTRGANGTQTTGGVKPPVHTGGAATAAKGVAGAVAVVLGGAVAVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SQ80</accession>
    <name>A0AAN6SQ80_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">6-phosphogluconolactonase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_47823</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cycloisomerase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854425">
        <property type="protein sequence ID" value="KAK4038557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SQ80"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050282">
        <property type="entry name" value="Cycloisomerase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019405">
        <property type="entry name" value="Lactonase_7-beta_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011045">
        <property type="entry name" value="N2O_reductase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344:SF1">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10282">
        <property type="entry name" value="Lactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50974">
        <property type="entry name" value="Nitrous oxide reductase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043010745" description="6-phosphogluconolactonase" evidence="2">
        <location>
            <begin position="20"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4038557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="391" mass="41150" checksum="B7B7298777194AB1" modified="2024-10-02" version="1">MSRFVQLFAAIALAPGALGATLIASHFAGGIYTLSLASTNCSSGTLSITSQTTGCGATPGWIELYSDSRKLYCFDESWLGSGSSAEFTVANDGRLSLTGQLKTTGNSVHGLLYGGTDGRGFVATAEYSPSTITTYKAPFSGAKQLQLEKFTLAQKGPNPRQDVAHPHEVHLDPTGKFIIVPDLGADLIRVFKIDASSGKLTACSEGKADAGDGPRHIKFWKSANGLQKAYTLNELGNSVSAWDVTYPTNDSGCLSLAKTQTLSTYAPGKKGGSTTKAAEIRVVGNFLYASNRADETFGSQQDSIATYTIDAATGAITWLEAANSYSYYPRTFQFNKEGTLLAVGGQTSSNVAIIARDTKTGKLGKLVANVQVGQKGRAGEEDGLSAVVWVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SQD2</accession>
    <name>A0AAN6SQD2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_47292</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854407">
        <property type="protein sequence ID" value="KAK4039214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SQD2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="31"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="135"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="405"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="506"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="90"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="413"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="506"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4039214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="531" mass="57716" checksum="70AE9BC8082B2D03" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SQS6</accession>
    <name>A0AAN6SQS6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_47727</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854421">
        <property type="protein sequence ID" value="KAK4038706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SQS6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000119">
        <property type="entry name" value="MFS monosaccharide transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF73">
        <property type="entry name" value="METABOLITE TRANSPORT PROTEIN YDL199C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="184"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="252"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="428"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="462"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="493"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="524"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="587"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="179"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="15"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="67"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="130"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="676"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="130"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="713"/>
            <end position="726"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4038706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="734" mass="80472" checksum="3C632B0DC27C4F36" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SR31</accession>
    <name>A0AAN6SR31_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">acetylornithine transaminase</fullName>
            <ecNumber evidence="5">2.6.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">C8A01DRAFT_16992</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 4/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.11" evidence="5"/>
    <dbReference type="EMBL" id="MU854414">
        <property type="protein sequence ID" value="KAK4038963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SR31"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003992">
        <property type="term" value="F:N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000004">
        <property type="entry name" value="Acetylornithine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01107">
        <property type="entry name" value="ArgD_aminotrans_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004636">
        <property type="entry name" value="AcOrn/SuccOrn_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050103">
        <property type="entry name" value="Class-III_PLP-dep_AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00707">
        <property type="entry name" value="argD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002325">
        <property type="entry name" value="PRK01278.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986:SF79">
        <property type="entry name" value="ACETYLORNITHINE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986">
        <property type="entry name" value="AMINOTRANSFERASE CLASS III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="9 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK4038963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="463" mass="49209" checksum="554D91F0C11E57EE" modified="2024-10-02" version="1">MAFRASLRLAAAVRPAATRFYSQAASVPTSSASSVTAAQIQRDAALPNPDPAEDSASAALIREHAPYMVATYARPPPVFVKGEGSYLWDIENRKYLDFTAGIAVNSLGHCDPEMSKLIAQQAKTLIHASNLYYNPWTGALSKLLIEQTLASGGMHDATSVFICNSGSEANEAGIKFARKVAKTLDPSGAKHEIVSFRNAFHGRTMGALSATPNPKYQAPFAPMVPGCRVGDLNDIASLPSLITPATCSVIVEPIQGEGGVQVASDAFLVALAARCREVGAVLHFDEIQCGLARTGSFWAHSHLPKEAHPDIVTTAKALGNGFPIGATLVNARVAEKIKVGDHGTTFGGNPLACRLAVRIVERLADPKLQEGVRVKGEVFREGFERLRGMFPGLVQEVRGKGLILGVQLSEDPTGIVKAARERGLLVITAGTNTLRFVPSLVMSEGEIREGLGILEEAIRATRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SRK8</accession>
    <name>A0AAN6SRK8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">lytic cellulose monooxygenase (C4-dehydrogenating)</fullName>
            <ecNumber evidence="15">1.14.99.56</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">C8A01DRAFT_35963</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the polysaccharide monooxygenase AA9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="15"/>
    <dbReference type="EMBL" id="MU854386">
        <property type="protein sequence ID" value="KAK4039997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SRK8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF36">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042865935" description="lytic cellulose monooxygenase (C4-dehydrogenating)" evidence="17">
        <location>
            <begin position="20"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="18">
        <location>
            <begin position="313"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="261"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="277"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAK4039997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="349" mass="35153" checksum="5DF15ED025AD3D47" modified="2024-10-02" version="1">MSKTSTLLAGLTGAALVAAHGHVSHIVVNGVSYENYDPTSYFYQPNPPTVIGWATTQQDNGFVEPNNVGTSDIICHRSGAPGGGHATVAAGDKISIVWDPEWPESHIGPVIDYLAACDGDCESVSKESLKFFKIDGAGYDKTAGRWAADALRANGNSWLVQIPSDLKAGNYVLRHEIIALHGGGSPNGTQAYPQCINLRVTGSGSALPAGVPGPSLYTASDAGILFNPYVPSPNYPVPGPALIAGAASSIAQSKSVATATASATVPGGGGANPNPTPASSTPAAGTPVPGTTLRTSTSTAAAQTTPPPTGGSSAQTKYGQCGGSGWAGPTACAAGSSCTVLNDWYAQCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SS32</accession>
    <name>A0AAN6SS32_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Velvet factor-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_36005</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854387">
        <property type="protein sequence ID" value="KAK4039953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SS32"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3960">
        <property type="entry name" value="Velvet domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021740">
        <property type="entry name" value="Velvet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037525">
        <property type="entry name" value="Velvet_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038491">
        <property type="entry name" value="Velvet_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572:SF17">
        <property type="entry name" value="SEXUAL DEVELOPMENT REGULATOR VELC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572">
        <property type="entry name" value="SPORE DEVELOPMENT REGULATOR VOSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11754">
        <property type="entry name" value="Velvet"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51821">
        <property type="entry name" value="VELVET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0749">Sporulation</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Velvet" evidence="7">
        <location>
            <begin position="268"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="88"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="154"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="236"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4039953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="450" mass="48822" checksum="BE6EBD1EFC067394" modified="2024-10-02" version="1" fragment="single">MSAAVDFAHHNFGRHTHLDGMAQHHGYHEPYAPGHGQYAQEQPFQQPPPQTKQLPRLPPMATMIPAAASNPSPVLSIGRDAPYHGGRPSYYSEYATPSPVGQTPPQLPIPNSDPHPMSKRAVDLRRSPTLSSTASDRSAEELAQELRLRQISSLHDPHGQGPVLPRQLIHYPSPRSRGGSLQHDGGALPPVLAKAPSYPSPSAIPNGSSRPQLPRSPPSTQPSTSPRQEPKSMSISNLLSGNASSSSSSSTTTTTTNHLPLPPTTAAPRTPTSEHRINVRQQPSAARSCGFGERDRRVIDPPPIVQLTIHDATLSQSDLAARLRHQFSVVHCSIWDEAGQHDMSSMPEDFRQQRRLMGTLVASPFVGLDEQGEEGCFFCFPDLSCRTPGVFRLKFALVVLDPARMCAGDRSAIVATAMSETFQVYNAKDFPGMQASTGLTKRLKEQGCLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SSA1</accession>
    <name>A0AAN6SSA1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosome biogenesis protein ALB1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_34669</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854360">
        <property type="protein sequence ID" value="KAK4041254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SSA1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4041254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="120" mass="13035" checksum="2E055838F8CF8107" modified="2024-10-02" version="1">MPSVKNPNAPSKNRLAARAAKQRKTRQQAAAQGQLVRQGGAIAKADARRGARPGLLPTSGPRAAISKKKQRKLERALGHAMKRKMERDGEVVMKEAPVEKKGEEKNKTEGGEAEAEMDIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SSM1</accession>
    <name>A0AAN6SSM1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Ribosome biogenesis protein NOP53</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_15524</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">May play a role in ribosome biogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the NOP53 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854373">
        <property type="protein sequence ID" value="KAK4040596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SSM1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011687">
        <property type="entry name" value="Nop53/GLTSCR2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14211">
        <property type="entry name" value="GLIOMA SUPPRESSOR CANDIDATE REGION GENE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14211:SF7">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN NOP53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07767">
        <property type="entry name" value="Nop53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017302">
        <property type="entry name" value="Gltscr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="161"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="246"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="293"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR017302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4040596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="436" mass="49642" checksum="3C2BF057D94C5601" modified="2024-10-02" version="1">MPVLKPLSGNPNAPQQYKQPSRKGKKAWRKNVDISEVQQGLEELTDQIIKGGVIAEKDSSELFTIDIEGDAELPKRFPKHVKKGLKADEIIAQRSAVPVVAMRKRPGDKTTDGVLPAKRQRTTYVTSKELSRIKKVADGHHESTVAVVDAEYDVWAEPVEEPTTEEQLFLPKTEKKKKPSTLAQQPISLAASGKSIPAVPKPKGGHSYNPAFNDYQDRLIEESDKAVEAERKRLEALAAERIKLEAAARSAAEAEAAEARADLSEWEDDSAWEGFESAGEELSVKAKRPRRKTQAERNKIKRRKEEERKAKHEAAMKRKRAQEERIKQIALEVAEKERQMELEKVEMSDASDDGNEIELRRRQLGKFKLPEKDLELVLPDELQDSLRLLKPEGNLLKDRYRSMLVRGKMESRRKIPFRKQARTKVTEKWTYKDFSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SSY5</accession>
    <name>A0AAN6SSY5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_14852</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854358">
        <property type="protein sequence ID" value="KAK4041392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SSY5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39398:SF1">
        <property type="entry name" value="CSN8_PSMD8_EIF3K DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39398">
        <property type="entry name" value="YALI0F14311P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4041392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="365" mass="39886" checksum="AA70491B3EA6202B" modified="2024-10-02" version="1">MQRKAGRAPSGHLSRLKPVEQDPLAEYGLPSKGEKRLLSPKVQESYYAQIAARYLAFCTAAGDRDNLQRQFARLSLTSTTSTSTSTTPSLSQSPIPTPLPPPSLSQHHHHPPQPPLPRKPETAQSQSQPTAQNQNRSKEEDPLPQILAALRKLREGLVASHRRDHFAAQVYLFSARLGILAGAYETYYPALLHLLRWGRGGHSPAHGPGPTNEFGVGAGTGKEGVGGGASASPLTTLEHHEVVSHLILDSACRRGDLAAAYALRSRHGLRDAKVDGVLRALVGDNWVVWRRIKKQVDGYRARLMEFAEARVTGHTLKAFGRAYLSVPVGVLEEQAGCEWGELKGRYQVGWEVDGGRVVIRKVQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6STG4</accession>
    <name>A0AAN6STG4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-oxoacyl-[acyl-carrier-protein] reductase</fullName>
            <ecNumber evidence="2">1.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_34591</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17397"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="1.1.1.100"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="2"/>
    <dbReference type="EMBL" id="MU854358">
        <property type="protein sequence ID" value="KAK4041393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6STG4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032787">
        <property type="term" value="P:monocarboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050259">
        <property type="entry name" value="SDR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42879">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42879:SF2">
        <property type="entry name" value="3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE FABG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="7">
        <location>
            <begin position="22"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4041393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="289" mass="29850" checksum="2018EBEC734F8F4C" modified="2024-10-02" version="1">MSERINQIARQLNYPGGLLAGQVAIITGSGQGIGAECARLFANEGAKVVVSDIDADKAENVASAIRASGGEALAVAGDLLKDECITELVKKAAAFGNGKIHILVNNAGFTWDAVIHKMTDKQWDTMLAMHGTAPFKLIRAAAPYFRVRDGAPRNIVNVSSTSGLHGNAGQLNYAMAKAGVVGLTKTIAKEWGPAFGVRANTVAFGHIETRLTADKEAGAFVEVDGQRVALGIPGKQKAAGGKGAVPYADIPLRRPGTATEAASAVLAVASPLSSYISGQTISVTGGRNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6STT3</accession>
    <name>A0AAN6STT3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exocyst complex component SEC5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_33094</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the exocyst complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the SEC5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854335">
        <property type="protein sequence ID" value="KAK4042844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6STT3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:Golgi to plasma membrane transport"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="InterPro" id="IPR029175">
        <property type="entry name" value="EXOC2/Sec5"/>
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    <dbReference type="InterPro" id="IPR039481">
        <property type="entry name" value="EXOC2/Sec5_N_dom"/>
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    <dbReference type="PANTHER" id="PTHR13043:SF1">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 2"/>
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        <property type="entry name" value="Sec5"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="83"/>
            <end position="1025"/>
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        <location>
            <begin position="21"/>
            <end position="88"/>
        </location>
    </feature>
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        <location>
            <begin position="183"/>
            <end position="225"/>
        </location>
    </feature>
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        <location>
            <begin position="563"/>
            <end position="602"/>
        </location>
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        <location>
            <begin position="1030"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
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        <location>
            <begin position="58"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="1034"/>
            <end position="1048"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010578"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU365069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF15469"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK4042844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1065" mass="117494" checksum="9CCAA9A044CD10A7" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SUD3</accession>
    <name>A0AAN6SUD3_9PEZI</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_12981</name>
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    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854327">
        <property type="protein sequence ID" value="KAK4043459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SUD3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="615"/>
            <end position="770"/>
        </location>
    </feature>
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            <end position="839"/>
        </location>
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        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="380"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="477"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="679"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="712"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="824"/>
            <end position="838"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4043459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1084" mass="114918" checksum="691BD03990CA6481" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SUF2</accession>
    <name>A0AAN6SUF2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">VHS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">C8A01DRAFT_44022</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May play a role in the regulation of membrane traffic through the trans-Golgi network.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Binds to ARF1 and ARF2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the ESCRT-0 complex composed of HSE1 and VPS27.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854333">
        <property type="protein sequence ID" value="KAK4042952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14235">
        <property type="entry name" value="GAT_GGA_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16998">
        <property type="entry name" value="VHS_GGA_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.160:FF:000003">
        <property type="entry name" value="VHS domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000008">
        <property type="entry name" value="VHS domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000024">
        <property type="entry name" value="VHS domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052653">
        <property type="entry name" value="ARF-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008152">
        <property type="entry name" value="Clathrin_a/b/g-adaptin_app_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008153">
        <property type="entry name" value="GAE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004152">
        <property type="entry name" value="GAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038425">
        <property type="entry name" value="GAT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041198">
        <property type="entry name" value="GGA_N-GAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47180">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-BINDING PROTEIN GGA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47180:SF1">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-BINDING PROTEIN GGA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02883">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03127">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18308">
        <property type="entry name" value="GGA_N-GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00809">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50180">
        <property type="entry name" value="GAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50909">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VHS" evidence="10">
        <location>
            <begin position="32"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="GAT" evidence="12">
        <location>
            <begin position="195"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="GAE" evidence="11">
        <location>
            <begin position="509"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="418"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="424"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="478"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00053552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00065344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK4042952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="631" mass="68350" checksum="B2EFB9CF6D1CF027" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SUH7</accession>
    <name>A0AAN6SUH7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sec1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_44435</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the flavin monoamine oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854339">
        <property type="protein sequence ID" value="KAK4042548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050281">
        <property type="entry name" value="Flavin_monoamine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007526">
        <property type="entry name" value="SWIRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043155">
        <property type="entry name" value="VPS33_dom3b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742">
        <property type="entry name" value="FLAVIN MONOAMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742:SF386">
        <property type="entry name" value="LYSINE-SPECIFIC HISTONE DEMETHYLASE 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09011">
        <property type="entry name" value="HMG_box_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04433">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="6">
        <location>
            <begin position="1451"/>
            <end position="1530"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="4">
        <location>
            <begin position="1451"/>
            <end position="1530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="639"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="688"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1547"/>
            <end position="1686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="649"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="726"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="776"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="1550"/>
            <end position="1574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="1590"/>
            <end position="1613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1614"/>
            <end position="1632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1634"/>
            <end position="1644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1645"/>
            <end position="1656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1676"/>
            <end position="1686"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4042548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1686" mass="181995" checksum="C4439718EA07ACCA" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SUN3</accession>
    <name>A0AAN6SUN3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_43875</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854330">
        <property type="protein sequence ID" value="KAK4043237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SUN3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000273">
        <property type="entry name" value="Leucine Rich Repeat domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454">
        <property type="entry name" value="NISCHARIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454:SF69">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 11-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52075">
        <property type="entry name" value="Outer arm dynein light chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="33"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="290"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="662"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="807"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="412"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="669"/>
            <end position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4043237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="851" mass="93127" checksum="BBC9C0800C5F4EF0" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SUP7</accession>
    <name>A0AAN6SUP7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Centromere protein Chl4/mis15/CENP-N</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_44237</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854336">
        <property type="protein sequence ID" value="KAK4042743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SUP7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034080">
        <property type="term" value="P:CENP-A containing chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007902">
        <property type="entry name" value="Chl4/mis15/CENP-N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05238">
        <property type="entry name" value="CENP-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="249"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="437"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4042743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="521" mass="56655" checksum="5AD29BF69CCCC7E6" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SUV8</accession>
    <name>A0AAN6SUV8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_43603</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854327">
        <property type="protein sequence ID" value="KAK4043477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SUV8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42052">
        <property type="entry name" value="ABM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42052:SF1">
        <property type="entry name" value="ABM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4043477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="231" mass="25221" checksum="60EBE547D254FEC9" modified="2024-10-02" version="1">MPVTEFALLHLTTTPPPAESLPPNPKNPILPTLASAMHIQSTWHATAFPALPSSAADRAAVWFAQVEDPSWLLTTARWASVDAHWDWIRSAENAGVMTGLEEGGYIVGGDTVLWHVGGEIFGGGGGSLLESPVVSVTRMFVARGDRGRFAGKFGEVRGVLEGYAGPNLVRFGWREDGEEGAEEDEFVLVCGWESVEQHFGFAEAEGFGRYGELRELIARTDLKHYKRLLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SUY5</accession>
    <name>A0AAN6SUY5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AAA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_31671</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854321">
        <property type="protein sequence ID" value="KAK4044074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SUY5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038727">
        <property type="entry name" value="NadR/Ttd14_AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13521">
        <property type="entry name" value="AAA_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NadR/Ttd14 AAA" evidence="1">
        <location>
            <begin position="18"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4044074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="225" mass="24729" checksum="F33530CC9543DD9A" modified="2024-10-02" version="1">MNPPLPTPSPPPLAPPNIYIVGAQCTGKTTLVANLHAHFTTADPHNPKAPPVRVITDVARTVLRAHNFTARDVRIPARSLALQRLVLQAQAAAERDVVIGAGPGGWFISDRSGADPIAYAMQYIGAEGVRALAESEQWGVLKRRMQEAVVVVCEVGPGVAGWLTDDGVRLMPEDLEEWVGFHRVFCEFLEGEGVRCEVLSAEVSGHEERVEFVLGRWRERWRERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SV80</accession>
    <name>A0AAN6SV80_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Glycosyltransferase family 20-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">C8A01DRAFT_42785</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the C-terminal section; belongs to the trehalose phosphatase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the glycosyltransferase 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854319">
        <property type="protein sequence ID" value="KAK4044344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005946">
        <property type="term" value="C:alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003825">
        <property type="term" value="F:alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004084">
        <property type="term" value="F:branched-chain-amino-acid transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004805">
        <property type="term" value="F:trehalose-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009081">
        <property type="term" value="P:branched-chain amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01557">
        <property type="entry name" value="BCAT_beta_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03788">
        <property type="entry name" value="GT20_TPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000099">
        <property type="entry name" value="Alpha,alpha-trehalose phosphate synthase subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1020:FF:000001">
        <property type="entry name" value="Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000036">
        <property type="entry name" value="Alpha,alpha-trehalose-phosphate synthase subunit Tps2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.10.10:FF:000010">
        <property type="entry name" value="Branched-chain amino acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.10:FF:000004">
        <property type="entry name" value="Branched-chain-amino-acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1020">
        <property type="entry name" value="Trehalose-6-phosphate phosphatase related protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033939">
        <property type="entry name" value="BCAT_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001830">
        <property type="entry name" value="Glyco_trans_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003337">
        <property type="entry name" value="Trehalose_PPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00685">
        <property type="entry name" value="T6PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788:SF15">
        <property type="entry name" value="TREHALOSE SYNTHASE COMPLEX REGULATORY SUBUNIT TPS3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788">
        <property type="entry name" value="TREHALOSE-6-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00982">
        <property type="entry name" value="Glyco_transf_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02358">
        <property type="entry name" value="Trehalose_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="16"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="904"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="904"/>
            <end position="918"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK4044344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1317" mass="146612" checksum="5D9CEE39C8570FE6" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SV83</accession>
    <name>A0AAN6SV83_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_43788</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854329">
        <property type="protein sequence ID" value="KAK4043298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SV83"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039327">
        <property type="entry name" value="CON7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36167">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36167:SF3">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="208"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="252"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="38"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="294"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="323"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4043298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="361" mass="39104" checksum="05EC371962A21466" modified="2024-10-02" version="1">MERAAPEYSQSGLPSPHPSVVGDTQSKAEPVDPASAAQYATQQEARASSYSNSATPTSEYSVYPTTSRSATFPDMQRSYHPANNPNGNGGGMPQTPTSPSMPLPDGRSHQNPQPEQAKSDSALPIDPSIAGASPTYATHSQYPPYAAPPQDMSQGYQHPGTPGLYTQPRPDWGGYGACHRRRSCFVPIPGAQQHKRPRRRYEEIERMYKCGHNGCEKAYGTLNHLNAHVTMQAHGVKRTPELFKDIRREWKAKKKEEDARKAAAAEEERQRQAAAAAAQNGGADPQAGVDAAQPPTSYPGTGTVQLPPIGYQPARYAGPPPAGMQQPMPEYSYPSYSPQSPYGQSNQQMYNPHNGGQPPSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SV88</accession>
    <name>A0AAN6SV88_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_43644</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854327">
        <property type="protein sequence ID" value="KAK4043520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SV88"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="611"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="729"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="869"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="964"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1051"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1109"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="619"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="735"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="758"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="870"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="881"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="999"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1014"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1053"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1184"/>
            <end position="1197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4043520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1197" mass="127722" checksum="C4993F1C85AABF0A" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SVD2</accession>
    <name>A0AAN6SVD2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Trimethylguanosine synthase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Cap-specific guanine-N(2) methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_32182</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78479"/>
            <dbReference type="Rhea" id="RHEA-COMP:19087"/>
            <dbReference type="Rhea" id="RHEA-COMP:19089"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:167623"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:78480"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78507"/>
            <dbReference type="Rhea" id="RHEA-COMP:19088"/>
            <dbReference type="Rhea" id="RHEA-COMP:19090"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:167623"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:78508"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78471"/>
            <dbReference type="Rhea" id="RHEA-COMP:19085"/>
            <dbReference type="Rhea" id="RHEA-COMP:19087"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:78472"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78475"/>
            <dbReference type="Rhea" id="RHEA-COMP:19086"/>
            <dbReference type="Rhea" id="RHEA-COMP:19088"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:78476"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. Trimethylguanosine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854325">
        <property type="protein sequence ID" value="KAK4043655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SVD2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071164">
        <property type="term" value="F:RNA cap trimethylguanosine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019012">
        <property type="entry name" value="RNA_cap_Gua-N2-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14741">
        <property type="entry name" value="S-ADENOSYLMETHIONINE-DEPENDENT METHYLTRANSFERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14741:SF32">
        <property type="entry name" value="TRIMETHYLGUANOSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09445">
        <property type="entry name" value="Methyltransf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4043655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="260" mass="28818" checksum="996B5D82E2C2BAD7" modified="2024-10-02" version="1">MTLRPVQDTLPLTEQCHHYDKIDQVPWDLQKYWHQRNSIFSFYDFGIRLTNDAWFGVTPEPVATQVAKDIRSHKHSTPRKDTIVDLFAGAGGNTIAFALSEKWTRVIGIEKDASTLACAQHNAGVYGVADAITWIHGDCLDFLARLKEANGNANGKEKKGKALDPSLQLDLASTVLFASPPWGGVSYRGHDVFDLSTMEPYNLATLHEACRPMEHALFLPRTSDVRQIAALVPEGGDKIEVVQYCMEGASKAMVAYMPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SWA0</accession>
    <name>A0AAN6SWA0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fungal N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_12250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854319">
        <property type="protein sequence ID" value="KAK4044408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SWA0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="321"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="190"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="206"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4044408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="711" mass="81363" checksum="81ECA2A622F9AA29" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SWC5</accession>
    <name>A0AAN6SWC5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_31265</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854318">
        <property type="protein sequence ID" value="KAK4044483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SWC5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17330">
        <property type="entry name" value="MFS_SLC46_TetA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF8">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G03730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="400"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="447"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="471"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="15"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="498"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="505"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4044483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="574" mass="62437" checksum="AB91B8A7DAC24CA5" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SWI6</accession>
    <name>A0AAN6SWI6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_12010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854317">
        <property type="protein sequence ID" value="KAK4044691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SWI6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053007">
        <property type="entry name" value="CYP450_monoxygenase_sec-met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47582">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47582:SF1">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4044691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="234" mass="24847" checksum="C203886AE50BD3A0" modified="2024-10-02" version="1">MAPPHLQNLIIQLGNVSPTLLVSGLVLLSLALVSLKRVLHPALDPREPPVLRPNVPFIGHTLSIVSEGVAYYDRLYKSARMPICTLPVLADKLYVINSATLIAAALRCPSLSFDPFVVLFSRNALAAGREDVQRLRDPGYVRSVKKSFYPSMSGEPLRGVVGAALREVAGAVNQLGRGGGGGGVCEMPNVGDWLREAISRAVVAALYGSGTPGLSIRSASSTRRQRTKRSGAGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P4F6</accession>
    <name>A0AAN6P4F6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_51500</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854823">
        <property type="protein sequence ID" value="KAK4031405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056125">
        <property type="entry name" value="DUF7708"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF14">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24809">
        <property type="entry name" value="DUF7708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NACHT" evidence="3">
        <location>
            <begin position="318"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1191"/>
            <end position="1232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4031405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1378" mass="152935" checksum="9F3F9F784BAC7859" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P537</accession>
    <name>A0AAN6P537_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_41634</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854677">
        <property type="protein sequence ID" value="KAK4031923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P537"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4031923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="353" mass="40269" checksum="CD465F9BC5758709" modified="2024-10-02" version="1">MSDKMIAALDDLEESAGMVMAWLRYENEYWRPTSSVEGNQSWQAIGAMCDACSAARKDLGHTHKEYSWHNLGPHAAGPLNHGYSEHRLQFEEDIWGFHPDEDDLGQYDGMDLVGRVNRDEATDLNRSAAIFLASLHSKHLPDLLKYHHCDSPYHTPPEEFAIVKARPGWLRRAVLRAKGLHWEYPCRQEAIFNDDDNANKANEGRYMYGWQDGSPAWRRSSWKHDDYYFYASAWPSALAAHRIVQEKVLPMVRESQAALAEAEALYQSTVVEAGKKLDVQMRELLAGRGWEVVEEAQIGTTPGGHLVEVSRAKDMADSLVDIHNVTMWRRMVLPMGKRAVEQLKRGRRKLAGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P697</accession>
    <name>A0AAN6P697_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Pre-mRNA-splicing factor SYF2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">C8A01DRAFT_40990</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">May be part of a spliceosome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the SYF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854596">
        <property type="protein sequence ID" value="KAK4032554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P697"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013260">
        <property type="entry name" value="mRNA_splic_SYF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13264">
        <property type="entry name" value="GCIP-INTERACTING PROTEIN P29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13264:SF5">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SYF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08231">
        <property type="entry name" value="SYF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="55"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK4032554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="317" mass="35481" checksum="3AD3EB2F997879D4" modified="2024-10-02" version="1">MPPAKKRRTTRSSAKAAQEEPAENETMPIPDEPAAAEPTVDKEPSPSPPSPPPAASSSSATPAAPAAATTSAQDRLARFRALQARAKASSDQNLKEATKESQRLATDPTQLTALNRKHAIASHKLLKADVEEAGEDFERKRAWDWTVEESERWDKRVRKRDAHRDDTAFRDYARESEKAYKRQLRNMGNPDLERYTRDKMAAIEKAAAAGTLDIVETDDGEMIAVDKDGTFFSTADSTAFAQHKPEKAAVDRLVADLRRAEEASLKRRKERMARNGEDGGDVTYINEKNKQFNQKLARFYNKYTAEIRESFERGTMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P770</accession>
    <name>A0AAN6P770_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_20071</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854563">
        <property type="protein sequence ID" value="KAK4032934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P770"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4032934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="102" mass="10972" checksum="AD355EDBD1D12E98" modified="2024-10-02" version="1" fragment="single">KGTKFIRPSGNPGEKKLKAPLFAAARLPPKTAIGGRGHRPLTLSFYGFGTRVSSFPRPAIPTRLGGSMRKNPVTPRQAPRAVTSRSVHLCDPTRDDSLLPAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P7K8</accession>
    <name>A0AAN6P7K8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">lytic cellulose monooxygenase (C4-dehydrogenating)</fullName>
            <ecNumber evidence="15">1.14.99.56</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">C8A01DRAFT_50189</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the polysaccharide monooxygenase AA9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="15"/>
    <dbReference type="EMBL" id="MU854547">
        <property type="protein sequence ID" value="KAK4033174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P7K8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF10">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042995638" description="lytic cellulose monooxygenase (C4-dehydrogenating)" evidence="16">
        <location>
            <begin position="21"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="17">
        <location>
            <begin position="21"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAK4033174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="254" mass="26933" checksum="BC54394C6B81DBDD" modified="2024-10-02" version="1">MAPLASATLILSSLASLVAGHGYLKSITVSGKDYLAWQVGQDDYVTPTPVRYARKLANNGPVPDFTTNNVTCGAGGNIPAGGVIDLKAGDTVSLNWDQWGSSRQYLAHCTNDDCKSFKGDTGDVWVKIEQLAYNPAGTPPWASDLLREQGAKWRVTIPPKLAPGEYLLRHEILGLHVAGTRMGAQFYPSCTQIRVTEGGSTQLPAGIALPGAYDPDDAGILAELWRINQGQVGYTAPGGAVWSEAAPNANREGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P7N3</accession>
    <name>A0AAN6P7N3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1996 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_50914</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854630">
        <property type="protein sequence ID" value="KAK4032255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P7N3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018535">
        <property type="entry name" value="DUF1996"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662:SF2">
        <property type="entry name" value="DUF1996 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09362">
        <property type="entry name" value="DUF1996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1996" evidence="1">
        <location>
            <begin position="15"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4032255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="324" mass="35808" checksum="4EBDC26F8F674AF3" modified="2024-10-02" version="1">MIRFSCSQLVVARMDPLVNPGLAQSPHVHQVVGGNSFNVIMDPASHDLVKDSTCTTCTFSEDFSNYWTAVLYFRARNGTYKRVRQFPNVGLRADGGVTVYYIPPYDGKTTVTAFKPGFRMLVGDAALHESKGMQKQLCHRCLGAGYDRGGAPCTGTDSQTLPTGFCEGGIRTTVTFPTCWDGKNIDSPDHKSHVAYPQVGTFESVGTCPESHPVRLPQLMYEVMWDTTEFNDKALWPEDGSQPFVWSTDDSVGYTQHGDYMFGWKGDSLQRALDARCGNAVCKELRTQTSEEAMRCTLPQNVPEQVDGWLEKIPGMGMVQGAEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P7Z5</accession>
    <name>A0AAN6P7Z5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">2-(3-amino-3-carboxypropyl)histidine synthase subunit 1</fullName>
            <ecNumber evidence="3 11">2.5.1.108</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">C8A01DRAFT_50014</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine = 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36783"/>
            <dbReference type="Rhea" id="RHEA-COMP:9748"/>
            <dbReference type="Rhea" id="RHEA-COMP:9749"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73995"/>
            <dbReference type="EC" id="2.5.1.108"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="11">Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the DPH1/DPH2 family. DPH1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.108" evidence="3 11"/>
    <dbReference type="EMBL" id="MU854533">
        <property type="protein sequence ID" value="KAK4033399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P7Z5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090560">
        <property type="term" value="F:2-(3-amino-3-carboxypropyl)histidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11840:FF:000001">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11850:FF:000001">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11860:FF:000002">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11840">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11850">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11860">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042263">
        <property type="entry name" value="DPH1/DPH2_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042264">
        <property type="entry name" value="DPH1/DPH2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042265">
        <property type="entry name" value="DPH1/DPH2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035435">
        <property type="entry name" value="DPH1/DPH2_euk_archaea"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00322">
        <property type="entry name" value="diphth2_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762:SF1">
        <property type="entry name" value="2-(3-AMINO-3-CARBOXYPROPYL)HISTIDINE SYNTHASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01866">
        <property type="entry name" value="Diphthamide_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004967">
        <property type="entry name" value="DPH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00032">
        <property type="entry name" value="Radical_SAM_3-amino-3-carboxyp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR004967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK4033399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="444" mass="48915" checksum="2E9C0553BAAA20EB" modified="2024-10-02" version="1">MEDDRVLVDLGIAAEIEEKEIQENAVKQPKKRFVGRRAAAEAAKSSSGTASIEDSGAIQVAQPRRAPRMLNQVPPEILNDEALKAAIALLPANYSFEIPKTIHRIRSLGAKKVALQMPEGLLLFATTISDILTEFCPGIETLIMGDVTYGACCIDDYTARAMGCDLLVHYAHSCLIPVDVTKIKTLYVFVDISIDTSHLLATLERNFSPGKTVALVGTIQFNATIHGVRSTLEKAGFKVIVPQIAPLSKGEILGCTSPNLSTYTDSPVDLILYLGDGRFHLESIMIHNPDIPAYRYDPYSRKLTHETYGHSEMQDIRRDAIRTAKKARKWGLILGSLGRQGNPHTMALIETKLTQMGIPFVNLLLSEIFPGKLAMMSDVECWVQVACPRLSIDWGYAFPRPLLTPYEALIVLEEKEDWGKGPYPMDYYGKEGLGRTKPAVVGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P873</accession>
    <name>A0AAN6P873_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Choice-of-anchor B family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_49887</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854523">
        <property type="protein sequence ID" value="KAK4033541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P873"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027589">
        <property type="entry name" value="Choice_anch_B"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38787">
        <property type="entry name" value="REGULATORY P DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38787:SF3">
        <property type="entry name" value="REGULATORY P DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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            <begin position="21"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4033541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="484" mass="53790" checksum="9F01A8573F1C8558" modified="2024-10-02" version="1">MATLNTIVTIMAALVTLSSAKELPVNMKLKAEMYENGVVHEHIMATKHRIWSEMADQGVFDSTQYHTFSEESDYIACEDGVAALVPNDPVNTFRCQDLDLFDFKTHAQLGSESGAGAGSWGWTSPEGREFVAIAQEDGAAFAEVNSRGKLVYLGRLPQYGKAPKSMWREIKGYGSYILIGSEALRHGIQIFDMSKLLDINPTNPVIFDSVDDLTGFWVEGLPMGRSHNVVTNEEMKYGVATGFQPRDGPLSAGLVFFDLTDPSNPKTLGGTGVDGYVHDAQCIVYRGPDKKYNGKDICYGYDEDSLTIFDVSDKKNVQVISNTSYEGFVYTHQGWVLDPQWQQYLITDDEYDEFNKTGLAADGYPISYIWDISSLESPKQTGHYKGLRRGIDHNQYVKDSFAYQSNYGLGLSILDLRSVPSDPTGKGIKEVAYFDTHPEDDHLPGGGNVTFTGSWSHYPFFSSGFIVINTLDRGAFVVKRSRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P881</accession>
    <name>A0AAN6P881_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_49901</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854523">
        <property type="protein sequence ID" value="KAK4033556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P881"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042919328" evidence="2">
        <location>
            <begin position="18"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="199"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4033556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="263" mass="26244" checksum="4342C502312482C0" modified="2024-10-02" version="1">MTRLISLMGLALAPVATQSTGLLTLFLPDSEPLSLEASAVAVNTVGRDPVTTLEVACPTAASPENDACRSAGIYPAQIYHTQGSVWGGTTTYAADDSTTTWVCSLGGSDPTLVGECTKTIVGGGSTRTETAEYGNCYVAAHQRPIVVTAGLEKITPAHFMTIDASKLVSLRSSQLAAAGCPASQTTIWAGAAASTTGGASSADATTSPLAGSSGVTTTAPTQTPADSASAATTSPSGAGKGGKDPMAALLLGLGLTMMLRMVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P955</accession>
    <name>A0AAN6P955_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_21093</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854711">
        <property type="protein sequence ID" value="KAK4031742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P955"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042895817" description="Extracellular membrane protein CFEM domain-containing protein" evidence="3">
        <location>
            <begin position="29"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="488"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="880"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="155"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="361"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="490"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="541"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="580"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="604"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="685"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="713"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="748"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="770"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="783"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="813"/>
            <end position="825"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4031742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="931" mass="98652" checksum="6CF8122693BA0EA4" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P9E8</accession>
    <name>A0AAN6P9E8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_18964</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854491">
        <property type="protein sequence ID" value="KAK4034174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P9E8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38166:SF1">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38166">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="416"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="377"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4034174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="482" mass="54481" checksum="8A4FA4D87BFEF0F7" modified="2024-10-02" version="1" fragment="single">AMFRPDRPGSTEHVLHRQPKLSSLGRQRELAEGAVGLKETKWSVRSSKNNIIGATMTEVLDDVQGPTRTASSEGLGVARHPSAPQATPHRSECWGGIRSSTCGRQSFEWETETLLDHSSDSPEDMASYPCPFRQRNPARFNVRDHEVCARSPFVSLRGLKHHIITHHGRKSVRHQCRRCNEQFENEIAFERHLRLPRDQMCEVKASPPVDYEEGISGEIASVMAARDPTEETWTWEGIWRLVFPDDDVPEPAHTLGQWKLTILAFQPVTELVEVEQAFDEGQELLKESLREKLQLLLPEAVDSSYLSFLTGQLELVFETHRVNVMKQSLGRGCPTVSGAQPSETQRAEQQSPPRKPNRRSRRSTLLQALQRNSQDTAAGLASRRASRANSAKPASHLFNEQSFWCRTEVQDRLPTNTIPRHFPAERNPTDARDKYNLNMNPRDSRDSGIGMPCDACDLDPDGGRFSPESFKQRVLRQQLMGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PA43</accession>
    <name>A0AAN6PA43_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11 12">Endo-1,4-beta-xylanase</fullName>
            <ecNumber evidence="4 11 12">3.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">C8A01DRAFT_18658</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11 12">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
            <dbReference type="EC" id="3.2.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11 12">Glycan degradation; xylan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11 12">Belongs to the glycosyl hydrolase 11 (cellulase G) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.8" evidence="4 11 12"/>
    <dbReference type="EMBL" id="MU854475">
        <property type="protein sequence ID" value="KAK4034549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PA43"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013319">
        <property type="entry name" value="GH11/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033123">
        <property type="entry name" value="GH11_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001137">
        <property type="entry name" value="Glyco_hydro_11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46828:SF4">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46828">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00457">
        <property type="entry name" value="Glyco_hydro_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00911">
        <property type="entry name" value="GLHYDRLASE11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51761">
        <property type="entry name" value="GH11_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11 12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9 11 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 11 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 11 12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11 12" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042897550" description="Endo-1,4-beta-xylanase" evidence="13">
        <location>
            <begin position="20"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="GH11" evidence="14">
        <location>
            <begin position="26"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK4034549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="220" mass="23493" checksum="7FB8FC1E48DACA04" modified="2024-10-02" version="1">MVAFTYLAVAAAAISGTFAAPAAGPDAPDFEVGAHNLARRQDYNQNYKTSGNINFSPTSNGYSVSFSNAGDFVVGKGWRTGTARNITFTGSTTQTSGTVLVSVYGWTKNPLVEYYVQEWTSNGAGSAQGQKLGTFQSDGGTYEIWKHQQVNQPSITGTATFWQYISNRVDKRPGSGTVTMANHFAAWNKAGLNLGTHDYQVLATEGWGNAGGNSKYTLQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PA53</accession>
    <name>A0AAN6PA53_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_39920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854519">
        <property type="protein sequence ID" value="KAK4033620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PA53"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="283"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4033620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="416" mass="45659" checksum="9994DC0F5E790C11" modified="2024-10-02" version="1">MGRLPNEIIANIISYLAADIESSSPFTLAPYATVSRAWQQRVEAATFAHIELTPARLASPLAAEALTPDRVRRFVRSVRVDVLLPPYDEQARGRREDEADRARNDGVFTDVVRRVFGLLAAATAPASESPAAIGGDGGCVAGDEGHDLEDLEAREYERCVSPIRVNDIFEARYESSYLDHSFQTPSILDETDRDNNDKLSLALCKLSQRLATFDLMADVGPEILWPLERTAPDHHHQQQHQDNDPLWPTMCHYTINPGPIAPSGKWRFQRLPDSDSDSDDDGSASSVSSSVAPGNEKEDPFRAMLDPDAARALLLAAARAARRMPALRKMEFMLDPPIWRDNGRLEVVYTAMAGTARGGTPLAPPGGGGATAELLVESRPVFHPDEEVVQAWREAAEEHSGIVSGLVVVVREHMAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PAP6</accession>
    <name>A0AAN6PAP6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7924 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_40710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854571">
        <property type="protein sequence ID" value="KAK4032841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PAP6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057684">
        <property type="entry name" value="DUF7924"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42470:SF2">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42470">
        <property type="entry name" value="VAST DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25545">
        <property type="entry name" value="DUF7924"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7924" evidence="1">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4032841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="118" mass="14023" checksum="7F1AC178F4D5C1F2" modified="2024-10-02" version="1">MTLAVRGIVELFRTIKREDEVNRKILAFSVSHDHRSVRLYGHYLVITRKDTKYYRHPIRTFDFIELDGEEKWIVYQFTKNVYDTWMPKHFENICSAINQLPSELNFDVLPLSEATGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PB75</accession>
    <name>A0AAN6PB75_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_19879</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854549">
        <property type="protein sequence ID" value="KAK4033141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PB75"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4033141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="257" mass="29699" checksum="9D7EDB52C297166C" modified="2024-10-02" version="1">MAPEMEYPAWFTRIYAKTNIPDPKDFDEDISEIGDEVPEYDFDSEHTDEKYDYYFSFITQREDRKVELQQLKEGKASQFDLEQGKKAQVQAAYEAMARAEAEGEDLTIDPEVFYEKLYNLYSPEFVQWTYDHYQLIGTNPGFLELRIPDPDETMVNGNLLLNQYNMSEHEGHEAQTSAGTAEHRISLSPNQGQPNEKLGINLREDTGKWSFGLVIIGEDHVLVRVSREFVFRSLSVEPPADAPEVFEFWGISQEIDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PC81</accession>
    <name>A0AAN6PC81_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_19694</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854536">
        <property type="protein sequence ID" value="KAK4033332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PC81"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043005082" evidence="1">
        <location>
            <begin position="31"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4033332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="95" mass="10621" checksum="32B7546FDC31374D" modified="2024-10-02" version="1">MDQQHRWRGLALVLLRLTALLLLLPAHASAQFFQPGEGEVWRVGDVKTIEYSTTMTNYTISLWQEVLPKSKSAIAGPVLVRKCRRSCPSPDASLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PC98</accession>
    <name>A0AAN6PC98_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heterokaryon incompatibility protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_17592</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854433">
        <property type="protein sequence ID" value="KAK4038304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PC98"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26639">
        <property type="entry name" value="Het-6_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="42"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4038304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="638" mass="71982" checksum="E6D5199FC443400D" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PCH3</accession>
    <name>A0AAN6PCH3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein NO VEIN C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_18936</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854488">
        <property type="protein sequence ID" value="KAK4034238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PCH3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4034238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="159" mass="18189" checksum="145373E924126C8F" modified="2024-10-02" version="1">MLLRLQPGLSGFSRENWQSTIRGYAAAHPNYSDLVAWVGRETADITYSDFDGAFTRLLIDKGYLASETWADARPHYLIEVKTTTGSCSTPFFMSKYQYRRMQRNSNHDNDNLETVYVVFRVFNLGNDNIGLRILVDPESMRLQDQLSFTAESWSVVAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PCK4</accession>
    <name>A0AAN6PCK4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_37688</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854431">
        <property type="protein sequence ID" value="KAK4038373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PCK4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF73">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G01020)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26639">
        <property type="entry name" value="Het-6_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4038373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="600" mass="66652" checksum="7016526D5CC6631B" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PDA3</accession>
    <name>A0AAN6PDA3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_17173</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854419">
        <property type="protein sequence ID" value="KAK4038778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PDA3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4038778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="119" mass="13645" checksum="D4D2B237DA02BD12" modified="2024-10-02" version="1">MTTRNLNQTWRDVVFNQYAADHAVDAPFPVRYLIHASQWQWDIIIEIPTKIDVAVLRRAVIDFCVAKRSEADPVYEDGRIKVRPRVSPRLPPSEVIRQGNDSQEDEAATTQDAPDIAWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PDE4</accession>
    <name>A0AAN6PDE4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_19193</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854502">
        <property type="protein sequence ID" value="KAK4033947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PDE4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021833">
        <property type="entry name" value="DUF3425"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116:SF9">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11905">
        <property type="entry name" value="DUF3425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="87"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4033947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="370" mass="40528" checksum="ECC8925552FA8BFD" modified="2024-10-02" version="1">MPPLLDDRPRTRHRVRKPPPTLAIPDIEHDAAERKRVLNVLAQRRYRQRKRESRVESEKSRQSSAQTSDGSRHELSPHSGTAGDVVDSPFLLPEDSSSPSLDFSQMDQASLDWLTCPLDGSTTFHPLHASNEIQGQPPSLPPVFLDIRCNSPNSNASALTCSPASANNDTQSEGIFSSDPDGTASLDGAATPASTSFPDRTTFSDSYFLAVPPLTLLRGLLRIASRLNAASSIGSLASTSPFNLGLGPDSSQLPAAWQPTPTQLSVPHHPLLDMLPWPSVRDRIIGVMALANDSGDGTTTGSRLVDFVYDMEDGAEGMRIWGSDPYDEASWEVGQVVFERWWFVFDKKVVEQSNTWWRRRGAAPLRALAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PE40</accession>
    <name>A0AAN6PE40_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_47229</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854405">
        <property type="protein sequence ID" value="KAK4039272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PE40"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="548"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4039272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="604" mass="66888" checksum="0D415D39C2B9AB66" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PE95</accession>
    <name>A0AAN6PE95_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">C8A01DRAFT_39144</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854482">
        <property type="protein sequence ID" value="KAK4034367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PE95"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF143">
        <property type="entry name" value="EXTRACELLULAR MEMBRANE PROTEIN CFEM DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00747">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="14" id="KW-0349">Heme</keyword>
    <keyword evidence="14" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 17" id="KW-0732">Signal</keyword>
    <keyword evidence="7 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042948571" description="CFEM domain-containing protein" evidence="17">
        <location>
            <begin position="25"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="266"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="18">
        <location>
            <begin position="12"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="389"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="429"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="429"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="14">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="40"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="44"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="54"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="63"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAK4034367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="465" mass="50334" checksum="1D3BEC1A81BE5856" modified="2024-10-02" version="1">MRSFRNTCAILGLCLLALSNAAAAAGSISVLEGYAALPDCARACFTSALGQSTCPVTDATCICADTNFDNVATVCIKSYCTIKETLTAKNLTSYMCGLPIERDSSLIPVYSVFIGLAVVAVILRLVARLLTHAYFWWDDFANLFGFIGSAVYTAMNIRAIDLGQSLDVWFVPFDNITLVVKISFVQMLLYTITRFFVRASIILFYLRVFPPSTDNKLGRILQFTMAFNVVYNFSFLFAVIFQCTPISDFWTQWEGANEGHCGNANILAWVAAATGIVFDLWLLALPFPQLLALNLHWKKKLLGGMMFFVGVAVMIISLVRLKTINEFTQAVNPTKDIVQVCLWSGIELDVGVICPCLPSFRLLLRRLLPRVMGTSGRYELDPVSNATGTGTGVMRSGLRKSFGGPPGTGPGIGGKIVVENTIAIKYGSGHGHGGGGGDGASVTGLVEGRASSGEDEERGVGERRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PEC1</accession>
    <name>A0AAN6PEC1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Palmitoyltransferase</fullName>
            <ecNumber evidence="13">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">C8A01DRAFT_39138</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Palmitoyltransferase specific for casein kinase 1.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Early endosome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="13">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="13"/>
    <dbReference type="EMBL" id="MU854481">
        <property type="protein sequence ID" value="KAK4034412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PEC1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161:SF85">
        <property type="entry name" value="PALMITOYLTRANSFERASE HIP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7 12" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0564">Palmitate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="388"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="487"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="535"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="78"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="112"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="145"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="178"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="211"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="15">
        <location>
            <begin position="438"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="595"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="15"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK4034412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="736" mass="80597" checksum="947825F9955D1698" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PEI5</accession>
    <name>A0AAN6PEI5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_36520</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="MU854399">
        <property type="protein sequence ID" value="KAK4039482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PEI5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="41"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4039482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="391" mass="43794" checksum="88D7AA9479918F3E" modified="2024-10-02" version="1">MDDLSCFEPSNLLHTQERMERYRPGGFHPVRLGDTFSGGRYTVHHKLGWGGFSTVWLARDQSLNKWVSLKITTATDPESSRELTLHQKLRQAGAADGVVQLLDSFIHEGPNGKHQCLVFELLGPTVDGVALDYHEGGDSLEAETVLRITRQLLQALAAMHRAGYAHGDVSGANVAFTARRLSGLASANDIFEIIGAPKTEKLVRCDGKALSPGMPEQLVEKAAWDDWIDEDDEDVRLIDFGEAFPHDTPRDHLAEPGGLQVPERIFTGEFDYRVDLWRAGCTIYGVVMGSRPFMYLGDMDFLVAQMIHFVEDLPEEWRPQWEQMQKSTGRIRDDIPDRMTGPSKLEEMFKKNVTEPSLGPLLPIINGLMRFRPEDRISAEEALILLDGPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PEK9</accession>
    <name>A0AAN6PEK9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heterokaryon incompatibility protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_37560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854427">
        <property type="protein sequence ID" value="KAK4038505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PEK9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF12">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="24"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4038505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="432" mass="49460" checksum="67560853D1A74631" modified="2024-10-02" version="1">MWLLNCANYRLEPNDLDGLSPKPYWILSHTWGDDEVTFQDMQNPTLAAQKKGFQKIKAMCELASANGQMYVWIDTCCIDKSSSAELSESINSMFYWYQKAARCIAYLEDLLPYRGMNIEDELRRCRWFTRGWTLQELLAPREVDFYDSQWNLRGTKGQICAELSNITKIDNDNLKFPSSDSLQRVPVARKMSWAAGRQTTRIEDKAYCLLGIFDVHMPLLYGEREQAFVRLQQTIAQKGNDMSLFAWIARPDDGPMKDLPPYSGLLASDPSQFAACSGVEPIRDPLLPSPSWIITNAGIEMTTALDCSTGLGHTVITRASDNTLRGERCPSVYSFCYRLFLHCQPWYWHDHFGTPDSGSHGFALWLRKTRSGFVRFRPTELCLVQRSAMDFNDPGPIRIAISLTRQQLYDTKSDLRLLSDASFVPHMLRWGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PEN9</accession>
    <name>A0AAN6PEN9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">protein-ribulosamine 3-kinase</fullName>
            <ecNumber evidence="1">2.7.1.172</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_17980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>N(6)-D-ribulosyl-L-lysyl-[protein] + ATP = N(6)-(3-O-phospho-D-ribulosyl)-L-lysyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48432"/>
            <dbReference type="Rhea" id="RHEA-COMP:12103"/>
            <dbReference type="Rhea" id="RHEA-COMP:12104"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:90418"/>
            <dbReference type="ChEBI" id="CHEBI:90420"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.172"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:48433"/>
        </physiologicalReaction>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.172" evidence="1"/>
    <dbReference type="EMBL" id="MU854447">
        <property type="protein sequence ID" value="KAK4035333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PEN9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102193">
        <property type="term" value="F:protein-ribulosamine 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016477">
        <property type="entry name" value="Fructo-/Ketosamine-3-kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12149">
        <property type="entry name" value="FRUCTOSAMINE 3 KINASE-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12149:SF8">
        <property type="entry name" value="PROTEIN-RIBULOSAMINE 3-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03881">
        <property type="entry name" value="Fructosamin_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00048655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4035333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="338" mass="38398" checksum="F0EBF965CF6ADCB7" modified="2024-10-02" version="1">MTTSFAVSVSSSLFEAHVNFFTPGTALPDVAEILAIEQLPGSRWARLSRIQVRHTDGGEESYFVKVSLGHHGREALKGEFEATSAIHAVTPDFCPQPIAWGSLRGDPDAHFYLCRYYEFSGKLPEPGPFCERLARLHKSHTSANGKFGFHCTTYNGDMPQDNIWFDTWEAFFANGLQHVLDVREERAGSDATLDSLLPALFENVIPRLLRPMESNGRRVQPCLVHGDLWFGNAAVVHGTGEPVVFDPAGFYAHNEYELGNWRPERNRFTRGGYFEAYHNHIHRTEPQEDYDDRNALYALRFNLHAATLFPDRDEFLQMAVDEIRRLVEKYPDGYTGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PER1</accession>
    <name>A0AAN6PER1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_16454</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854397">
        <property type="protein sequence ID" value="KAK4039551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PER1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="66"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="111"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="148"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="4"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="221"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="266"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4039551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="370" mass="40628" checksum="53C0C12295F170FF" modified="2024-10-02" version="1">MLLAAVHYGVGKHNYYVPDDEEVLAEKWLFLSQPPFPWSLALSKMSIAWMLIRIQRDRPWWTWSMYFLMFTSFGVAVVSNIFQLSVCKPLWAVWDHSNPDAVCTDPNTSQISIYVTACITIVTDVALSLAPLTFIVTMHRPFREKAMLAFVMGLGIVASSSSIAKTMVVGSYGKTGDTLMDTVPLTTWSMVEAQLAIIAACIPTLKRLFEQILRRNGLISSQNSTSRSHSGYYKHDGGTRSRTYSQHHRENSHKLSVMRSQRDAAAKNSAAATTTTTVNAETSSLDSGEMPIMKPSHKGSIGDFESVNSSSPAPAANLNGDNGVYFRTAIKAGDRGVNGVDRHGIQMETTVSVRTEPKTRPGRGEGGDIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PF83</accession>
    <name>A0AAN6PF83_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF8021 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_36426</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854397">
        <property type="protein sequence ID" value="KAK4039552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PF83"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058334">
        <property type="entry name" value="DUF8021"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26061">
        <property type="entry name" value="DUF8021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042841074" description="DUF8021 domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8021" evidence="2">
        <location>
            <begin position="151"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4039552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="280" mass="29984" checksum="2CD3E1552947A59E" modified="2024-10-02" version="1">MKAQSILLATTALATCAAAECTRSFLVDATAKYVAAQTEGKPATLAAIAADTLNYTESDKTVDIKTGVLAQAMKIDHNRSIHDTTLCATFTELIVADGAKPYVIGTRMVFTDNKASLIETIATKPGDWAFNATGYLHWNSLETWDPIPLDKRDSRAVIQAAGDAYFNRFNNASFAVPFGTPCARLEGGAYTDPRGSGNGTCDLGLPSTITVTNRRYVVDEEMGAVSIYLGFPGLDRSVADKPMPDSHFFRVEAGEIRYIHTVTTCEHAGCGMNGTGIPPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PG98</accession>
    <name>A0AAN6PG98_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endoplasmic reticulum junction formation protein lunapark</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_46978</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a role in determining ER morphology.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The C4-type zinc finger motif is necessary both for its ER three-way tubular junction localization and formation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the lunapark family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854397">
        <property type="protein sequence ID" value="KAK4039568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PG98"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098826">
        <property type="term" value="C:endoplasmic reticulum tubular network membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071788">
        <property type="term" value="P:endoplasmic reticulum tubular network maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903373">
        <property type="term" value="P:positive regulation of endoplasmic reticulum tubular network organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040115">
        <property type="entry name" value="Lnp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019273">
        <property type="entry name" value="Lunapark_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22166">
        <property type="entry name" value="ENDOPLASMIC RETICULUM JUNCTION FORMATION PROTEIN LUNAPARK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22166:SF12">
        <property type="entry name" value="ENDOPLASMIC RETICULUM JUNCTION FORMATION PROTEIN LUNAPARK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10058">
        <property type="entry name" value="Zn_ribbon_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Lunapark zinc ribbon" evidence="3">
        <location>
            <begin position="256"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="145"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="327"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="174"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="199"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="331"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="350"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4039568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="379" mass="41371" checksum="40D462C891B56E3F" modified="2024-10-02" version="1">MVSFWRWGKEDSSPASFEKALSALSAKITTTQTQLDQNRAKSRRVKVLCSLYLGFAYLVYGIVLVLVVGWRSMGPWEWTGIAGGPIVIYLVRAITTAFFDYRIQRLSVRLKEYQTERAKTIQKLKDATKYDSTLELLEKYGGAENKQKKGKKAVEEGDGAEQAKDGRAKVKHPGLPPRTNIPPPPTANIQRPPVPGPGTPQSRPHSRLGTPSQPALAQPDMDASAEFAPNAFDGRPPPAFMQYPPAAMAPPAESHWYDRILDTLLGEDETAAKNRIVLLCSNCHLVNGQAPPGTKSLSELGMWKCMACGASNGEMDEGRRIVQEVLGARTPDVKAETDDNASRSSSDLVEVEKDVSEAEPEGKSSAAEGPRKRRGKGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PGJ2</accession>
    <name>A0AAN6PGJ2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycosyl hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_16415</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854396">
        <property type="protein sequence ID" value="KAK4039600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PGJ2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06591">
        <property type="entry name" value="GH31_xylosidase_XylS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051816">
        <property type="entry name" value="Glycosyl_Hydrolase_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43863">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G03140)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43863:SF2">
        <property type="entry name" value="MALTASE-GLUCOAMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 31 N-terminal" evidence="4">
        <location>
            <begin position="22"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="3">
        <location>
            <begin position="231"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="5">
        <location>
            <begin position="576"/>
            <end position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4039600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="661" mass="75753" checksum="4783B793FE52A273" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PGL6</accession>
    <name>A0AAN6PGL6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_35355</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854373">
        <property type="protein sequence ID" value="KAK4040593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PGL6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4040593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="134" mass="14287" checksum="9A69E6B6C5D402BF" modified="2024-10-02" version="1">MEWKDTYDANADPYESAGKIKKWYRNGYVAEVDWSSDEVRQLFQIQTANTTSASPSPQAESASAPVGAIAGGVVGGVAGLAAMAAVAWLVVRRRRRTRKGQEADLADAKDSGMPELNTASDYAELNGGRLSGSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PGL9</accession>
    <name>A0AAN6PGL9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF427 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_35603</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854378">
        <property type="protein sequence ID" value="KAK4040367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PGL9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.40">
        <property type="entry name" value="Domain of unknown function (DUF427)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007361">
        <property type="entry name" value="DUF427"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038694">
        <property type="entry name" value="DUF427_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43058:SF1">
        <property type="entry name" value="DUF427 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43058">
        <property type="entry name" value="SLR0655 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04248">
        <property type="entry name" value="NTP_transf_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF427" evidence="1">
        <location>
            <begin position="25"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4040367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="166" mass="18990" checksum="4B0E0A3CDF6041DC" modified="2024-10-02" version="1">MSAMRKHNVTTFPRPPIVERTNRHIQIKWHGQLVADCPPGEAYWVLEAHHAPMYYIPPSRVRLPLSTTPRSTFSEFHGAATYYAIMSPISAAEILSNRIWSYNEPPKEYEAIKGYLAFYVGPWECYVDNERAHPPPGDYYGGWVTSDIEGLVKPPHQWGTGWDGVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PGS1</accession>
    <name>A0AAN6PGS1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RmlC-like cupin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_46329</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the pirin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854379">
        <property type="protein sequence ID" value="KAK4040347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PGS1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02247">
        <property type="entry name" value="cupin_pirin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02909">
        <property type="entry name" value="cupin_pirin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012093">
        <property type="entry name" value="Pirin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008778">
        <property type="entry name" value="Pirin_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003829">
        <property type="entry name" value="Pirin_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13903:SF8">
        <property type="entry name" value="PIRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13903">
        <property type="entry name" value="PIRIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02678">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05726">
        <property type="entry name" value="Pirin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="Pirin N-terminal" evidence="4">
        <location>
            <begin position="106"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Pirin C-terminal" evidence="5">
        <location>
            <begin position="261"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4040347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="386" mass="41765" checksum="52469A8E93423750" modified="2024-10-02" version="1">MRTFSPVTIAISVIVGVCSILALLKRQDILDFAATNSVLSQLIPTNTVSIINTTTAPENNNIPTSTSTPTSTPATMSAATNTTTKLLPRLIRTAFLAVEQSEGAGARVRRSIGTPKLRNFSPFLMLDHFSVPPGAGFPDHPHRGQETITYLMQGGIDHEDFAGNKGRLGPGDLQFMTAGRGIVHAEMPVQNEDGSANVGIQLWVDLPKHLKGCEPRYRDLRAEEIPVVEADGGRVTVKVISGQSHGVDSVKDLAYTPVWLLDVEVRPGGKVVQPLPEGWNAFAYTLEGEVLIGEEGAQRPVGEFHNVVFEGEGQAVYAAVDEGAEKSARFVLVAGTPLDQKVVQYGPFVLTSQEEVYQAFMDYQTHSNGFERADGWESEIGKSMVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PHN2</accession>
    <name>A0AAN6PHN2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_15075</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854363">
        <property type="protein sequence ID" value="KAK4041148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PHN2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4041148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="159" mass="18568" checksum="10E1D99EBCF973CB" modified="2024-10-02" version="1" fragment="single">HLMINFFSSAWVQCIGLGTSNVAGHTKKAIYAAATLIAYSVFCLTRKFQFFLELHWHHDLCFVVCFLCAEILRFILARENKKRENDAQELEDFTDRENKSFRYISLVMGNDEHFNSEEYEPCIQRGIFVTLKDTGDLQVVALPLHFQQPREIQWMLNSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PIB1</accession>
    <name>A0AAN6PIB1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Clr5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_45350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854356">
        <property type="protein sequence ID" value="KAK4041499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PIB1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025676">
        <property type="entry name" value="Clr5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38788">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38788:SF3">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14420">
        <property type="entry name" value="Clr5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Clr5" evidence="2">
        <location>
            <begin position="48"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4041499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="536" mass="60278" checksum="D5E975C1662B8A3F" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PIW8</accession>
    <name>A0AAN6PIW8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Pre-mRNA-processing factor 19</fullName>
            <ecNumber evidence="16">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">C8A01DRAFT_47107</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 16">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the WD repeat PRP19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="16"/>
    <dbReference type="EMBL" id="MU854401">
        <property type="protein sequence ID" value="KAK4039385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PIW8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070534">
        <property type="term" value="P:protein K63-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16656">
        <property type="entry name" value="RING-Ubox_PRP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000027">
        <property type="entry name" value="Pre-mRNA-processing factor 19, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.10">
        <property type="entry name" value="Diaminopimelate Epimerase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003719">
        <property type="entry name" value="Phenazine_PhzF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038959">
        <property type="entry name" value="Prp19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013915">
        <property type="entry name" value="Prp19_cc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055340">
        <property type="entry name" value="RING-Ubox_PRP19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00654">
        <property type="entry name" value="PhzF_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43995">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43995:SF1">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02567">
        <property type="entry name" value="PhzC-PhzF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08606">
        <property type="entry name" value="Prp19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54506">
        <property type="entry name" value="Diaminopimelate epimerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0227">DNA damage</keyword>
    <keyword evidence="13 16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5 16" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="12 16" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="14 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0697">Rotamase</keyword>
    <keyword evidence="7 16" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="6 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 16" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="4 15" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="U-box" evidence="17">
        <location>
            <begin position="371"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="15">
        <location>
            <begin position="649"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU367101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAK4039385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="852" mass="90976" checksum="C175E6AA4BED9DE6" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PJ10</accession>
    <name>A0AAN6PJ10_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_36572</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854400">
        <property type="protein sequence ID" value="KAK4039445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PJ10"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4039445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="312" mass="34878" checksum="7FC4A55846F3E551" modified="2024-10-02" version="1">MEDDDTAEEESENGEAEDHEMGDGNAAVDDGAAGNEAVAPGSSTDDKPDEEPLKADSPWPDEPSREMVLRLAECSWLDERLASGQRPDPTARDAIMSAFSSLHFLDCLKGSALNSDNLGIDHAGHVFEIRPDGWVQRDYRRDFSDLRSTLRRKASDASATDEIRKQIRTYMDFDATGLLWESADVETENLVRLVRDMVRQNDFAVPKLKSIRAECEKAMAEMGKTVALANAVKQDLLDTGSTSLKRWKQLRSIGRRLGWSIGRMAVPEMPTPKDIDELVEDITQDSASYHRCFGYTLKLKWDLDSAIDDLSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PJ56</accession>
    <name>A0AAN6PJ56_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Halotolerance protein 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">C8A01DRAFT_34912</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="MU854364">
        <property type="protein sequence ID" value="KAK4041068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PJ56"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13994">
        <property type="entry name" value="STKc_HAL4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000183">
        <property type="entry name" value="Serine/threonine-protein kinase hal4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24343:SF558">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24343">
        <property type="entry name" value="SERINE/THREONINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="204"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="10"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="61"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00078109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK4041068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="488" mass="54356" checksum="5112A2241B1698AD" modified="2024-10-02" version="1">MTSSGHSVASTSPRASPRISPRSSQPPSIKSVEVPSKSPKLNGQNGLPPVPAGATENAQRPADKGSMKDRLTRMFSTRDVSSRAVTPDTTNGTAQAKKPQDATPTTTSPPPTKPATAKEAPPQRFLLNLEVQGGHEHHLKSSRRQEKLTDLIKNFLGRKPEQVPDHDLSLVSNWVDNLRQEKDGASSEKKTASNPSATLVEKYGKCQEIVGRGAFGIVRISHKKLDNGLGEKLFAVKEFRRRPEETEKKYSKRLTAEFCISSSLRHPNVIHTLDLLKDSKGDYCEVMEFCSGGDLYTLVLSAGKLEVQEADCFFKQMMRGVEYMHEMGVAHRDLKPENLLLTTHGALKITDFGNGECFRMAWENDAHMVSGLCGSAPYIAPEEYTAKEFDARAVDVWACGVIYMAMRTGRHLWRVARKDEDEFYTRYLEGRRDEEGYAPIEALHRARCRNVIYSILDPNPGRRITASQVLKSEWGREIQLCKAGEEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PJF9</accession>
    <name>A0AAN6PJF9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">C8A01DRAFT_15953</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="MU854383">
        <property type="protein sequence ID" value="KAK4040139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17917">
        <property type="entry name" value="DEXHc_RHA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000819">
        <property type="entry name" value="ATP dependent RNA helicase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000500">
        <property type="entry name" value="ATP-dependent RNA helicase DHX29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000002">
        <property type="entry name" value="Putative ATP-dependent RNA helicase DHX36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF145">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX57-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0934">Plastid</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="671"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="918"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="237"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="321"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="387"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="606"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="44"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="248"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="322"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK4040139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1482" mass="165504" checksum="77264EE874CBFB07" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PJQ9</accession>
    <name>A0AAN6PJQ9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_35727</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854380">
        <property type="protein sequence ID" value="KAK4040304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PJQ9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018810">
        <property type="entry name" value="UPF0662"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28086:SF1">
        <property type="entry name" value="CU(2+) SUPPRESSING AND BLEOMYCIN SENSITIVE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28086">
        <property type="entry name" value="UPF0662 PROTEIN YPL260W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10303">
        <property type="entry name" value="DUF2408"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4040304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="451" mass="51448" checksum="D3EA7C7AE3C15BC9" modified="2024-10-02" version="1">METPAVPMPKDERERQILDKLTVIQNSLLLLKRDRTQYIRTQDVMVLHDQLVEQVRLVNEIRKGEHKGENRLDKVLESCLQLISLFFMTIGRTTEVPAAYALTSTIKRVLDHLTEASLFSPKDLSSISNTLSKLEGILANNESEHSPYLVELLANRETLCKSMLANLRKQLDQLDEPLQAIYERLISVMRSMSLANTKSKFSTTEVQKLKSKLQEIDESRVDGKFLDEEGKELRGSEVVSVLLGRCLLWSDIVLERKGAIPDGFKNMYNILINIRNDLEKLSITQAWSLRETDLYDFQRQLDKIDEARVDGNWLDQDGRPAELYVQRTLLYLIRRSYGYIYYLMISSEPVSEALLPVYNQLQTLKRCLIEVKNSGGVGSVRELYPYSMKLNSIDNMRVDGKFMVGNDIPEGQGSISELLAECFDLNYDLRVAAEELEDGEKKSPAPQAAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PK72</accession>
    <name>A0AAN6PK72_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">P-type Ca(2+) transporter</fullName>
            <ecNumber evidence="2">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">C8A01DRAFT_13941</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="2"/>
    <dbReference type="EMBL" id="MU854341">
        <property type="protein sequence ID" value="KAK4042401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PK72"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000040">
        <property type="entry name" value="Calcium-transporting ATPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000028">
        <property type="entry name" value="Calcium-transporting P-type ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="859"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="932"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="966"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="996"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1033"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="15">
        <location>
            <begin position="56"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="174"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="649"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="34"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="177"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK4042401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1076" mass="116024" checksum="6B5AB11E4AEC8FB0" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PKW9</accession>
    <name>A0AAN6PKW9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Stretch-activated Ca-permeable channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_13479</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854334">
        <property type="protein sequence ID" value="KAK4042879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PKW9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024338">
        <property type="entry name" value="MID1/Yam8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39142:SF1">
        <property type="entry name" value="AEL197CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39142">
        <property type="entry name" value="MID1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12929">
        <property type="entry name" value="Mid1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042927985" evidence="2">
        <location>
            <begin position="36"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4042879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="644" mass="69353" checksum="811548DB25EA8262" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PLR1</accession>
    <name>A0AAN6PLR1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Component of IIS longevity pathway SMK-1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_43696</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854328">
        <property type="protein sequence ID" value="KAK4043383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PLR1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030289">
        <property type="term" value="C:protein phosphatase 4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072542">
        <property type="term" value="F:protein phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006887">
        <property type="entry name" value="P4R3-like_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051137">
        <property type="entry name" value="PP4R3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23318">
        <property type="entry name" value="ATP SYNTHASE GAMMA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23318:SF0">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 4 REGULATORY SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04802">
        <property type="entry name" value="PP4R3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine-protein phosphatase 4 regulatory subunit 3-like central" evidence="4">
        <location>
            <begin position="61"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="611"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="672"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="649"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="691"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="756"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="784"/>
            <end position="809"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4043383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="841" mass="92600" checksum="2C5B020921154829" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PP13</accession>
    <name>A0AAN6PP13_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Sodium/calcium exchanger protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">C8A01DRAFT_42782</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854319">
        <property type="protein sequence ID" value="KAK4044342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PP13"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000016">
        <property type="entry name" value="Membrane bound cation transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000011">
        <property type="entry name" value="Vacuolar calcium ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF18">
        <property type="entry name" value="CA(2+)_H(+) EXCHANGER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="97"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="418"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="453"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="484"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="516"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="544"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="39"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="418"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="215"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="223"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="245"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="312"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK4044342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="577" mass="61182" checksum="3D494B74D48382FD" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PPH1</accession>
    <name>A0AAN6PPH1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Calcineurin subunit B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Calcineurin regulatory subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Protein phosphatase 2B regulatory subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">C8A01DRAFT_31015</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Composed of a catalytic subunit (A) and a regulatory subunit (B).</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the calcineurin regulatory subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854316">
        <property type="protein sequence ID" value="KAK4044829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PPH1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050801">
        <property type="term" value="P:monoatomic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000047">
        <property type="entry name" value="Calcineurin subunit B type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45942">
        <property type="entry name" value="PROTEIN PHOSPATASE 3 REGULATORY SUBUNIT B ALPHA ISOFORM TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01697">
        <property type="entry name" value="PARVALBUMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="21"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="60"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="90"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="131"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK4044829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="174" mass="19662" checksum="5329CF3A5BC9E63A" modified="2024-10-02" version="1">MGNTTSAVLDNIVQGSNFDRDEVDRLRKRFMKLDKDNSGTIEREEFLSLPQISSNPLATRMIAIFDEDGGGDVDFQEFVSGLSAFSSKGNKEQKLRFAFKVYDIDRDGYISNGELFIVLKMMVGNNLKDQQLQQIVDKTIMEADLDGDGKISFDEFQKVVENTDVSMSMTLDQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PPP3</accession>
    <name>A0AAN6PPP3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_42560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854317">
        <property type="protein sequence ID" value="KAK4044652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PPP3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="302"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4044652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="377" mass="43485" checksum="578E1ADD283C87C0" modified="2024-10-02" version="1">MASQNPSASPALPALPPASSGSEHHIALVSLNVSTIEEIIEYIISARHSGSDSIVSFHWQANQVDDLFEQLEARLLEVDERKIRRVEYDYESETVYLDITGESEFHYQVQAGLRDYLRNSLAKLLVATDDTEIRRLIRRATEQGSVPVEYENKLYKQADSEPRQYVERKVRQYIDLSDGKIRLAVVVDLQYSDVKKGWISLLAADDSDSIRHWVQHSDLFHDDDLVQPVGQVDFYLSDFVGLAGVPAAFCRPSTAEVAAGVSRKPQIILPYERLAAIFRVARSIHDPAKFDVEDGDEEENPYECLAQELIERERRMAEMKRRIAEKERHIAEKERRMAEEERRVAEMEQRVAERERRVAEELAEFERRMAERRLQAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2025-10-08" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PPU5</accession>
    <name>A0AAN6PPU5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">C8A01DRAFT_44261</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDPK1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="MU854336">
        <property type="protein sequence ID" value="KAK4042766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05581">
        <property type="entry name" value="STKc_PDK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10568">
        <property type="entry name" value="SWIB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000163">
        <property type="entry name" value="3-phosphoinositide-dependent protein kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000128">
        <property type="entry name" value="Serine/threonine-protein kinase ksg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.245.10">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039046">
        <property type="entry name" value="PDPK1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019835">
        <property type="entry name" value="SWIB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036885">
        <property type="entry name" value="SWIB_MDM2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003121">
        <property type="entry name" value="SWIB_MDM2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF163">
        <property type="entry name" value="3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02201">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00151">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47592">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51925">
        <property type="entry name" value="SWIB_MDM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="271"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="domain" description="DM2" evidence="13">
        <location>
            <begin position="1096"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="14"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="417"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="559"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="767"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="982"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1042"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="421"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="782"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="805"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="857"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="982"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="995"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1015"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK4042766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1327" mass="147006" checksum="00FB9E96B3A3C757" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PQP3</accession>
    <name>A0AAN6PQP3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Complex I-ESSS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">NADH-ubiquinone oxidoreductase ESSS subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">C8A01DRAFT_42895</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Complex I is composed of 45 different subunits. Interacts with BCAP31.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFB11 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854320">
        <property type="protein sequence ID" value="KAK4044218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PQP3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019329">
        <property type="entry name" value="NADH_UbQ_OxRdtase_ESSS_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40637">
        <property type="entry name" value="ESSS SUBUNIT OF NADH:UBIQUINONE OXIDOREDUCTASE (COMPLEX I) PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40637:SF1">
        <property type="entry name" value="ESSS SUBUNIT OF NADH:UBIQUINONE OXIDOREDUCTASE (COMPLEX I) PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10183">
        <property type="entry name" value="ESSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="7 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00031387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00046528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAK4044218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="121" mass="13547" checksum="5934F7CB9A552ACF" modified="2024-10-02" version="1">MSALRPTARLAARTTISSTTSPSTALVPARFRFFSTTPRRAGGGGMQYDPPSGWLWGVRPGEKYQNEGWEGPFFYGFWGSIIVFAVAYAWKPDTSIQTWALEEARRRLEAEGILEDPETKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PQW4</accession>
    <name>A0AAN6PQW4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin-like protease family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_32351</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854326">
        <property type="protein sequence ID" value="KAK4043619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PQW4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016929">
        <property type="term" value="F:deSUMOylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016926">
        <property type="term" value="P:protein desumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12606:SF141">
        <property type="entry name" value="GH15225P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12606">
        <property type="entry name" value="SENTRIN/SUMO-SPECIFIC PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="6">
        <location>
            <begin position="1013"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="90"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="172"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="402"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="804"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="926"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="57"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="804"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="866"/>
            <end position="880"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4043619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1224" mass="138091" checksum="2BF95DAE9C0D0C6F" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PR55</accession>
    <name>A0AAN6PR55_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tyrosine specific protein phosphatases domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_11897</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854317">
        <property type="protein sequence ID" value="KAK4044715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PR55"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140096">
        <property type="term" value="F:catalytic activity, acting on a protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046464">
        <property type="term" value="P:acylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14502">
        <property type="entry name" value="RNA_5'-triphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000273">
        <property type="entry name" value="Dual specificity phosphatase catalytic domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000090">
        <property type="entry name" value="Dual specificity phosphatase catalytic domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF5">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE ABHD6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="2">
        <location>
            <begin position="490"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4044715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="582" mass="64017" checksum="1E49324AF319FC8D" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PRD3</accession>
    <name>A0AAN6PRD3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDB1- and CUL4-associated factor 13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">WD repeat and SOF domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">C8A01DRAFT_43507</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat DCAF13/WDSOF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854326">
        <property type="protein sequence ID" value="KAK4043561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PRD3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001074">
        <property type="entry name" value="Probable SOF1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007287">
        <property type="entry name" value="Sof1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051733">
        <property type="entry name" value="WD_repeat_DCAF13/WDSOF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22851:SF0">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22851">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA U3 SNORNA ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04158">
        <property type="entry name" value="Sof1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0853">WD repeat</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042814534" description="DDB1- and CUL4-associated factor 13" evidence="11">
        <location>
            <begin position="27"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="81"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="298"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="341"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="Sof1-like protein" evidence="12">
        <location>
            <begin position="374"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="435"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK4043561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="465" mass="52626" checksum="81D310372C3CCE4E" modified="2024-10-02" version="1">MSSGGSGPWRLRLLWLLWLGPGSALSRSISTQQAPGSDVQRAPRNLAPEIHPFERAREYQRALNAVKLERMFAKPFLGQLGSGHVQGVYSMCKDKNSLNSVASGSGDGVIKVWDLTTRDNETWRTAAHSNIVKGLTFTNDKKLLSCATDGIKLWDPYNTPKDTTPLATWQEGGPYTSLSVHRTGNVFAASSGAGCIRVWDLEQSTAAQAIQWPNHTDTITDVCFNQVETSVIGSVATDRSLILFDLRTNMPVIKTVLHFAANRVVFNPMEAMNMAVASEDHNIYIFDARNFSKAQNIQKGHVAAVMDVEFSPTGEELVSGSYDRTIRIWRRDQGQSRDIYHTKRMQRVFRTMWTMDSKYLLTGSDDGNLRLWRANASERSGVKSTKQRQALEYNSALVERFSHMPEIKRIRRHRHLPKVIKKAGEIKRDELAAIKRREENERKHSDKKFQKRKGEREKAVLVKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PRE6</accession>
    <name>A0AAN6PRE6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Endonuclease/exonuclease/phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_42474</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854316">
        <property type="protein sequence ID" value="KAK4044865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PRE6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09083">
        <property type="entry name" value="EEP-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050410">
        <property type="entry name" value="CCR4/nocturin_mRNA_transcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121">
        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121:SF36">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="14"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4044865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="291" mass="32530" checksum="4B95F52790DB459E" modified="2024-10-02" version="1">MTTSNSTSLHIRLVTFNIRYATKNPGLGEEPWPVRCPRLCAQLRFLASGHDSAFVCLQEVLHSQLTDVQARLGPSWSHIGQGRKDGKEAGEYSPIFFRVDHWECERSRTYWLSPTPEVPSKGWDAALERIVTMGAFRHRVTGAVVVVMSTHLDHKGEVAREESARLLLKLARTWPGDCAPAARPPVFLGGDFNSTPTGRAYKVLTDPSSGMRDISHLVPDDAKHGNREMTFTSFGDSNEPPARIDFLFVSDAERLRFLTFGILPNMFDDHVYLSDHRPVIADIEVPVHAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PRG9</accession>
    <name>A0AAN6PRG9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_31822</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854322">
        <property type="protein sequence ID" value="KAK4043949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PRG9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="215"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4043949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="337" mass="38766" checksum="DF9BDBAF47980109" modified="2024-10-02" version="1">MSDPSRRRHTSDRDPPRRPPASSTTTPSSRDSRDARDSRDSRDPRRAPPPISSSNRPPPPLSSSRPPPTPSSSRPPPPPQSDPYGDEGPGSPEAPPDEYDLHQDERDDRLAQHWEECADDIEQDPTYPVVIDDTLANDIFSVLGGQPRLYSVPRIPRLGDGLGRGGRGRGKVDDVRVALVNGDDLSEIQRCFCGKSKATVVVDREERFAFVPTSMRSSAGPSSAAAVVAEMPIRGGPPPPSSSQGRESRREEPSRREEPRRREEPSRREEPRRREEPRRREEPSRREEPRRREEPSRREEPRRREEPRRREEPRRREEPRRREEPRRREEEYKGERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PRH1</accession>
    <name>A0AAN6PRH1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_13187</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854329">
        <property type="protein sequence ID" value="KAK4043270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PRH1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="57"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4043270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="368" mass="41088" checksum="BBDFE86EE7CACD0E" modified="2024-10-02" version="1">MANPQTTKLSEEVLRELSSTEYACSSLKPLSGGSANFIFKATLTTPLPDGTKEVAIKHGEDYVASNAEFQIPTTRCRAEVECLKALGGLPSTQGAYAVRAPKFYYFNPDTNTQVQEYLPHALSLKEYALKHFSSRDPSRKPLCLELGRSLGLWLRSFHDWASLPEQARLREEMKSNEPMQKIKHMVNYSTLVDTVANFPSILADAKETLVQIKDATAVELQRPDLQITHGDFWTGNALLPDQSLEEGSQMPVFIVDWEMCQFSQPPLDLGQMIAELYELSLFKDIDEGKWLIEGFAAGYGYVDDAFAFRTALHVGTHLIAWGTRVQGWGSEAQVQQVVGVGKDIILRAWHQDRAWFESGDLACLFGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PRT0</accession>
    <name>A0AAN6PRT0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_31713</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854321">
        <property type="protein sequence ID" value="KAK4044114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PRT0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4044114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="503" mass="55341" checksum="3A2D278FC62F7A5A" modified="2024-10-02" version="1">MAIFVNYDGPKLDTEQKRVVRSRAMVVVRGRRKQAKSPARDDSSSGNSSHSGSPEDDAQHAQQALAVSSRPVANSSRKRDNLKPWMAVAGQSQRAAPNLHLNPYDLRGAPPRSTHMTGVDARTFQDYLSRCGSYSSYLDEAFVLVGFRQPSYFRPDLSKAACIYIGWLLTAGVLDAFRGTREIAYPYYEYQAVRELQKFVDGADERQLHEVVYPVLILGMFEMVRFSPRTITHLAAVEGFIKSRGGLRMMPDVMQHLVLMADTLQCVCLGTPLAFNVLAPTPTLRLTTADGFPAGNQLRSCPLLLCDAEDLSLAGQYADTAVRARLVDVLQAAHDAFRHFFFDPAGAQSTLGECGLDLDTVANSMGSSAAAANSVPHRLLETCALAARITRNTLSGEVDGFDDAGNALDVQLIYEHTRFMGLKAWTGLPYVYVWVNLIGFAASTEARMRSYFVAEVVRCAFSYGCYQMEVFQAVLRNFLHLRNAIAGRKTVLAAYAAGELGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PS25</accession>
    <name>A0AAN6PS25_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_12922</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854326">
        <property type="protein sequence ID" value="KAK4043570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PS25"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4043570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="164" mass="18139" checksum="C170E2863001CAA2" modified="2024-10-02" version="1" fragment="single">PPDFVLPPGPKIVVVRVDRDALQHLNPSMDPLTDDDGPSRVLRKGKTALDQARLELSVELFDDDFPCLASRTVWPQPGVSATTESVPFLTKYVGFYFKHDVTAGDLRPAIFMLTSEGDPVDNCIRFHAVEVAEHRKDGVLENVRFIEEAIMGKGPGKDQVANLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PSV6</accession>
    <name>A0AAN6PSV6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_11918</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854317">
        <property type="protein sequence ID" value="KAK4044699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PSV6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41390">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41390:SF1">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 213 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4044699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="245" mass="26124" checksum="24F3BA26E583C5AE" modified="2024-10-02" version="1">MKRMVVQNPEDENRQSRSSTSSPSPPPAAETGPVERTRPRQNQSFPPDLMEILVPSLKVGAAAGACGVFTGAAAGIIRSAPTLFFSVIAGGQWFTLGTSYYATRLICLRHFGEGEQTPGDKVKASTVAGGVAGTMGGLLRGPRNIIPGAVMFSLFGAGGQAIANWRATRIANAAPKTSSGFWSRWSPIKQLSDQDYENILEEKLLRVEADIALIDDRIKELRESESQIKDGDSEGGKSRGSSNKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SKQ0</accession>
    <name>A0AAN6SKQ0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_21537</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854978">
        <property type="protein sequence ID" value="KAK4031214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SKQ0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF279">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="1">
        <location>
            <begin position="39"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4031214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="485" mass="51363" checksum="A32A396C99BA5E97" modified="2024-10-02" version="1">MPSISTGLPVPHPTRSYWQSVPSALDKHQSVQHLPASCDILIIGGGYAGAATAYHLLKSAASRNTRPSVVLLEARGACSGATGRNGGHLRPDLTSAPVLLSERYGPRAAAAVAQFEMDHLAAIAQFVAEEDVDCDLTEATSFDVFTTPEQAAAARERHDLLRKEPAFAGLLAAVGLYAGDDAPDRTGVRDAKAYFCSPAAHLSPYKLTMGLLSRALELGLCLKTHTPVLSILEDADDASRADEAAAAEDDEDVRVRPRCHRITTPQGAITATKIVVATNAYTAALLPEYAAAIVPCKGLACHIAAASPSSPPLPRLPTSSLCIRVQQGPLSGYTYLVQRADGSVVAGGAHHTYKQTDPASWYGTVDDAGLIEPAWRYYCDGPPGFAARALVGWVPRTRTCVDHVWTGIMGYSADSLPHVGAAPGRDGVFVLAGFHGHGMPVAYLAAKGVAEMVWEGKTYEETGLPAVYKTSQERLMPRYDDILGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SKW6</accession>
    <name>A0AAN6SKW6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Opsin related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_50973</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the archaeal/bacterial/fungal opsin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854639">
        <property type="protein sequence ID" value="KAK4032171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SKW6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15239">
        <property type="entry name" value="7tm_YRO2_fungal-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001425">
        <property type="entry name" value="Arc/bac/fun_rhodopsins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043476">
        <property type="entry name" value="Yro2-like_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28286">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28286:SF1">
        <property type="entry name" value="30 KDA HEAT SHOCK PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01036">
        <property type="entry name" value="Bac_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00251">
        <property type="entry name" value="BACTRLOPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01021">
        <property type="entry name" value="Bac_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4032171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="282" mass="30591" checksum="28FA2F39E81BDBD6" modified="2024-10-02" version="1">MTFLPRNDVFTANPPIGLDVALSVNGSNWLWAVTAIYLVSFIGLLCFCFASPENQRVFHYTFTVALLVGGATYFAQAADLGWSAVHDDGAVRQLFYAKYINWAVSFPAVALALGLLSGVSWTTIVCNIALVWTWVLTCLAAAYTTTSSSYGWGFFAFGTLCWLVLAMSTLNESREEAARRGIARDYVLLAAWPNLLWLLYPVAFALSDGASVIGVTGGAVFFGVLDVLMVPVLSFAFVFLGRNWDWARLELDFSEYRGSGQARALLDKPSSPAVQGGLGSQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SL39</accession>
    <name>A0AAN6SL39_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_41900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854738">
        <property type="protein sequence ID" value="KAK4031649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SL39"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="368"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4031649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="415" mass="46766" checksum="CB8A2321F11DD1E7" modified="2024-10-02" version="1">MEKIPAELYDVIVTQLHDSFCLCGSKNSGRSAWDSARCVSFGWDAQNSKRLQRELCKLRLVNKKFLGPATRCLLSHGTLAFDVSFLDGLSISAQTQYCLAKENQNIVARVSGLRIDLLLSGFSRHLHLLDLQQPGSHVITASRIKEAESARGKFLRALPSLGKRFKSVKALEIRLDGADKRHSRHESKIKSFIRKTLPKLESLYLSCDTKDALSIMDKMSERQCSQLRRLLVHSKSQWAVTWDFTERFQSLAELEMSLCFQGPLKLHPLNQGLTRLRLANIWTSEEHLIRVIKQCPARYANHSDGGSPLVDLVLRSVNLDAVTDGSTTYEMGTWSEVFRTTRDCCPKLTFLRVNSVTYDGQVGVFAPQQVLIEEMERERADIAELQSLIECVRSRRGRVASGLVSSLVGAITHEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SL41</accession>
    <name>A0AAN6SL41_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_41158</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854614">
        <property type="protein sequence ID" value="KAK4032396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SL41"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4032396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="238" mass="26609" checksum="F39D1AF650966AC3" modified="2024-10-02" version="1">MASADSSDEWRPGADGPDSDLSDLEIAAPPPRRFSTFGQDSMNSMVATAAEDRALTKRNQKERTFKSLVPGTDRLYLLWSNGFDWFRVNTLKQNLTDTPNDYQLERFIDGIVRHIGRRTATGTASTIAQLINDGLATNAQIREPLWITSDLIRRMNTAIIKDAMEEGTMSWDCIILSVVILSLQSALSARAGEIGRSRDYKGEEYLAYKDIDIRWVDTNDGKGKLSCVITLRAEKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SL80</accession>
    <name>A0AAN6SL80_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_51498</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854822">
        <property type="protein sequence ID" value="KAK4031407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SL80"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4031407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="329" mass="37730" checksum="F6AE666851E132BA" modified="2024-10-02" version="1">MDYVDGHSLKDLGFKSGSETWGSLIFAGPQTPAARHLHRQLADVYVQLRQLEFPRIGALGLCSRDVSALTCNPQEISVCNRPLSIDMALQELDGLQPGNIFPPRKTLSTASEFVGGLLRLAHNKLEKELDQGMDEDEPASILYAAHHFKRFVQDEWLDRSANQGPFVLMHGDMENVISNLLFDKDYNLVGILDFVLLIQEDYNKQVGYLRAAIQELEKALGLLPYLSTEWAPLEKCAIAIGLNYPEHAYLVYWDLIFRKLVPRLRGATQEQRDQQHEKEVVPRIKAFMDASEERQAFLERKIQEQLEYFEAEKEHYGYKAPRRIVKRIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SLH4</accession>
    <name>A0AAN6SLH4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_51446</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854790">
        <property type="protein sequence ID" value="KAK4031485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SLH4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF34">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G00480)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4031485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="341" mass="37992" checksum="6233F38680203925" modified="2024-10-02" version="1">MSNDTSGTVPGSVYIYEPNRAASIFFAAAFLASGLFHVWQCLWYHHWKVTALLPFSCALLTAAFATRAYGAFNHYDDAQVYTASTLLMYMSPPLLQLSNFLLLARLFHFVPYFSPMHPSRMLVTFASLAAVIELLTIAGTAYLTNRDLPDKSLRVGDTLAKAALVVQLLVAGLFFLLAGIFHRCCRAGGIRTPRVTYPLVAAYGSMVLLVGRTVYRMVEHFGSPLLSTRVLAEEPLSLGPAVRYEWYFYVFDAALVLLAVVVWNVVHPGRFLPEDPRRYLAQDGVTVLTGPEWKDSRSLTETFFDPFAMLTTRGGHQKQFWEHNGYALGAARRGAGTTRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SLW3</accession>
    <name>A0AAN6SLW3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">DUF221-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">C8A01DRAFT_41096</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854608">
        <property type="protein sequence ID" value="KAK4032459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SLW3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022257">
        <property type="entry name" value="PHM7_ext"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF53">
        <property type="entry name" value="DUF221 DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12621">
        <property type="entry name" value="PHM7_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="487"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="533"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="578"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="626"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="691"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="738"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="766"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="12">
        <location>
            <begin position="55"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="13">
        <location>
            <begin position="226"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="10">
        <location>
            <begin position="485"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="domain" description="10TM putative phosphate transporter extracellular tail" evidence="11">
        <location>
            <begin position="925"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="297"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="264"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="332"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK4032459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1033" mass="115951" checksum="94D53C05367F1941" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SMC1</accession>
    <name>A0AAN6SMC1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_39829</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854514">
        <property type="protein sequence ID" value="KAK4033701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SMC1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17316">
        <property type="entry name" value="MFS_SV2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000171">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF4">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="163"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="409"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="434"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="496"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="71"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4033701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="525" mass="57172" checksum="3EE865FE81C2722A" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SME1</accession>
    <name>A0AAN6SME1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">thioredoxin-dependent peroxiredoxin</fullName>
            <ecNumber evidence="3">1.11.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Nuclear thiol peroxidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Thioredoxin peroxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">C8A01DRAFT_41079</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the peroxiredoxin family. BCP/PrxQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.24" evidence="3"/>
    <dbReference type="EMBL" id="MU854606">
        <property type="protein sequence ID" value="KAK4032475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SME1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03017">
        <property type="entry name" value="PRX_BCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000157">
        <property type="entry name" value="DOT5p Nuclear thiol peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050924">
        <property type="entry name" value="Peroxiredoxin_BCP/PrxQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42801:SF23">
        <property type="entry name" value="PEROXIREDOXIN DOT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42801">
        <property type="entry name" value="THIOREDOXIN-DEPENDENT PEROXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="15">
        <location>
            <begin position="46"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="216"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="217"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="243"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="254"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00077538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK4032475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="270" mass="27806" checksum="BF78830BDAAAF684" modified="2024-10-02" version="1">MPMELRKRKEAPAPPPPARKKTTKTAAATAKTAAAKAKDAVKEKVAEVAAAAPTNGASDKPAVGTTIALDGFGGEIETNDGAKTTLKALVDESKAGVVLFTYPKASTPGCTRQACLFRDAYTALTSTSGLAIYGLSTDSPKANTTFQTKQKLPYPLLCDPDATLIGAIGLKKAPKGTTRGVFVVDKTGKVLASQAGGPEATVGVVREVVEGLVGGSEEVKGAVEEAEKEEGGKDEEGKGEDVPMADEAGEANEEEGKKAEENGEGEKKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SMJ1</accession>
    <name>A0AAN6SMJ1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_50614</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854589">
        <property type="protein sequence ID" value="KAK4032625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SMJ1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013226">
        <property type="entry name" value="Pal1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28307:SF1">
        <property type="entry name" value="PAL1 CELL MORPHOLOGY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28307">
        <property type="entry name" value="PROTEIN PAL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08316">
        <property type="entry name" value="Pal1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="132"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4032625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="468" mass="51689" checksum="DC4D49B8034F0B8F" modified="2024-10-02" version="1">MGDRDYDGVAVDKQWASKYILGPLYDPEPSQVCATHVKPLPTPPTSASPTRGYFSQEHRKTAIDNSDEERPFLHRVLSRANSVKRKPLPPSPPRATYPPLSGLERKRSVHTANPPQTRWNQGTILARANSVSAPRPSADAMAAAGDQNTHRRRASSLAERYPGDRSHRPLEMLTQEHRAREAGEDTLPRRSGSLRERYPGDMSHRPLAMLTRQHRAADRAPHLHNHRRQQPSDTIDTLDVTGPVPGATYHHGGPFDATLKERNTNKKYAPVEAVKDTNMEALKATPAEFVQDSLVKHVPLQGTAVVPPGMQDMAGRTMHYEEGADLMREEDAAGGAYKRWDHIRYRDDDLKGKGEPSFSHDQQTRRSGKQPAAGGTVYYEMQPSPSSFRDYRHGGSDSKRKDGGGATHVRQRSVSNGGAQGMGGEEGEAGSSGLQRSNTTSGKNNLAQSLKRRFGSLRRRRAGEEAGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SMS1</accession>
    <name>A0AAN6SMS1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">mitogen-activated protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">C8A01DRAFT_50455</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="1"/>
    <dbReference type="EMBL" id="MU854570">
        <property type="protein sequence ID" value="KAK4032850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SMS1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050538">
        <property type="entry name" value="MAP_kinase_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016">
        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016:SF56">
        <property type="entry name" value="MAPKK KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="192"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="483"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK4032850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="603" mass="66482" checksum="37E1466F87296991" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SMT0</accession>
    <name>A0AAN6SMT0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_50424</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854567">
        <property type="protein sequence ID" value="KAK4032880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SMT0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4032880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="377" mass="42468" checksum="BA9ECC2908442732" modified="2024-10-02" version="1">MGNATDELTDNGTTSSASARVICEEFLKVLGRKEVEQPMICQNLCLCAQFWRYQHYLLPLWKQRGITKMVCFGLGSFRNVQQNGGPFPGGPSKQQHTYRAVIRDKTPLQEEFNTRPVDRHDALQAMLRHVAAVEVASMLKFCSSRRGVEHQLIKYYFKKLTAVQDLPTGGAVGIDEKTVKKLGKMPPTAGYAGDEDLVDVPVYLWDGEYAEQDRDALGRLAAVFEVAHLPPVEVVEGGDVRDACRLVDEHTLVYAVDPDFPVRSMVLGRCKPGAMIWRDHAVDVESDVLVNDIRPLLDDYEEFKLDKRHAPHTVGSSHLYIRKDIVEAAEREKIVPPYPVTFPHDYPYKLNNWYLDKLERNGSGKVQLKEGDGGGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SN02</accession>
    <name>A0AAN6SN02_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Haloacid dehalogenase-like hydrolase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_50071</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854538">
        <property type="protein sequence ID" value="KAK4033312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SN02"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008252">
        <property type="term" value="F:nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006206">
        <property type="term" value="P:pyrimidine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.450:FF:000001">
        <property type="entry name" value="SDT1p Pyrimidine nucleotidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010237">
        <property type="entry name" value="Pyr-5-nucltdase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052791">
        <property type="entry name" value="SSM1_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01993">
        <property type="entry name" value="Pyr-5-nucltdase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47438">
        <property type="entry name" value="PHOSPHATE METABOLISM PROTEIN 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47438:SF1">
        <property type="entry name" value="PHOSPHATE METABOLISM PROTEIN 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01132">
        <property type="entry name" value="C1.5.3:_5'-Nucleotidase_Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4033312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="238" mass="27613" checksum="FCEF0B6B69F67E05" modified="2024-10-02" version="1">MEPTANGASPKQVFFFDIDNCLYPKSAKVHDLMADLIDRYFVTHLSLPWDDAVRLHKEYYQNYGLAIEGLVRHHQIDPLEYNAKVDDALPLDDVIKPRPELKKLLADIDRSKVRLWLFTNAYVNHARRVIRLLEIEEFFEGITYCDYADVPLTCKPHPDMYAKAMREAGVEKHEDCFFVDDSYQNCKKAQELGWTVAHLVEEDVKPPRTPACQFQIRHLVELREVFPQCFKGSAPEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SN53</accession>
    <name>A0AAN6SN53_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_40064</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854528">
        <property type="protein sequence ID" value="KAK4033462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SN53"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4033462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="72" mass="7935" checksum="A7913818BD999E10" modified="2024-10-02" version="1">MPKRDYTTPMPTPTDTNTNTTTNTNPDYPTNQTAEIFAVALVLFAGLFGASSLHYRHELLRDSRNGSTLDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SNB5</accession>
    <name>A0AAN6SNB5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">[histone H3]-trimethyl-L-lysine(9) demethylase</fullName>
            <ecNumber evidence="2">1.14.11.66</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">C8A01DRAFT_18536</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 2 2-oxoglutarate + 2 O2 = N(6)-methyl-L-lysyl(9)-[histone H3] + 2 formaldehyde + 2 succinate + 2 CO2</text>
            <dbReference type="Rhea" id="RHEA:60200"/>
            <dbReference type="Rhea" id="RHEA-COMP:15538"/>
            <dbReference type="Rhea" id="RHEA-COMP:15542"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="1.14.11.66"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the JHDM3 histone demethylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.66" evidence="2"/>
    <dbReference type="EMBL" id="MU854468">
        <property type="protein sequence ID" value="KAK4034721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051864">
        <property type="term" value="F:histone H3K36 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140684">
        <property type="term" value="F:histone H3K9me2/H3K9me3 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15571">
        <property type="entry name" value="ePHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.650:FF:000024">
        <property type="entry name" value="Putative jumonji family transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034732">
        <property type="entry name" value="EPHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003349">
        <property type="entry name" value="JmjN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694:SF7">
        <property type="entry name" value="[HISTONE H3]-TRIMETHYL-L-LYSINE(9) DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02375">
        <property type="entry name" value="JmjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13832">
        <property type="entry name" value="zf-HC5HC2H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00545">
        <property type="entry name" value="JmjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51805">
        <property type="entry name" value="EPHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51183">
        <property type="entry name" value="JMJN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="JmjN" evidence="8">
        <location>
            <begin position="113"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="JmjC" evidence="9">
        <location>
            <begin position="390"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="10">
        <location>
            <begin position="640"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="23"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="204"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="573"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1059"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1219"/>
            <end position="1447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1466"/>
            <end position="1562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="42"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="78"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="212"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="245"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="315"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="576"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="606"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1085"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1111"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1223"/>
            <end position="1247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1291"/>
            <end position="1301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1308"/>
            <end position="1322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1344"/>
            <end position="1354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1364"/>
            <end position="1378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1379"/>
            <end position="1441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1499"/>
            <end position="1562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK4034721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1562" mass="171344" checksum="1098BCAF8F9C0648" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SNX3</accession>
    <name>A0AAN6SNX3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">chitinase</fullName>
            <ecNumber evidence="4">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">C8A01DRAFT_39279</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="4"/>
    <dbReference type="EMBL" id="MU854487">
        <property type="protein sequence ID" value="KAK4034272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SNX3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00035">
        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02878">
        <property type="entry name" value="GH18_zymocin_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036861">
        <property type="entry name" value="Endochitinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053214">
        <property type="entry name" value="LysM12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47700:SF2">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47700">
        <property type="entry name" value="V CHITINASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G13720)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57016">
        <property type="entry name" value="Plant lectins/antimicrobial peptides"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="6" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="11 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043044450" description="chitinase" evidence="15">
        <location>
            <begin position="25"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="16">
        <location>
            <begin position="264"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="16">
        <location>
            <begin position="328"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="17">
        <location>
            <begin position="471"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1100"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1103"/>
            <end position="1118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAK4034272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1172" mass="124096" checksum="E26A5642D3293085" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SNZ9</accession>
    <name>A0AAN6SNZ9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_48958</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854468">
        <property type="protein sequence ID" value="KAK4034709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SNZ9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4034709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="794" mass="88937" checksum="D40CD1EFA081C39F" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SPA7</accession>
    <name>A0AAN6SPA7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_18179</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854455">
        <property type="protein sequence ID" value="KAK4035099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SPA7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4035099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="593" mass="67677" checksum="BCECA460495689F4" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SPR0</accession>
    <name>A0AAN6SPR0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_17793</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Sodium-phosphate symporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854440">
        <property type="protein sequence ID" value="KAK4038092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SPR0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001204">
        <property type="entry name" value="Phos_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101">
        <property type="entry name" value="PHOSPHATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101:SF80">
        <property type="entry name" value="PHOSPHATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01384">
        <property type="entry name" value="PHO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="229"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="466"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="553"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="305"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="318"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="333"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4038092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="586" mass="63036" checksum="00729E9CABF3B2D8" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SQ07</accession>
    <name>A0AAN6SQ07_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Uracil-DNA glycosylase</fullName>
            <shortName evidence="7">UDG</shortName>
            <ecNumber evidence="7">3.2.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">UNG1</name>
        <name evidence="11" type="ORF">C8A01DRAFT_17924</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.</text>
            <dbReference type="EC" id="3.2.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.27" evidence="7"/>
    <dbReference type="EMBL" id="MU854445">
        <property type="protein sequence ID" value="KAK4035383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SQ07"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097510">
        <property type="term" value="P:base-excision repair, AP site formation via deaminated base removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10027">
        <property type="entry name" value="UDG-F1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.470.10:FF:000007">
        <property type="entry name" value="Uracil-DNA glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="entry name" value="Uracil-DNA glycosylase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00148">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002043">
        <property type="entry name" value="UDG_fam1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018085">
        <property type="entry name" value="Ura-DNA_Glyclase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003588">
        <property type="entry name" value="PRK05254.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003589">
        <property type="entry name" value="PRK05254.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003592">
        <property type="entry name" value="PRK05254.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00628">
        <property type="entry name" value="ung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11264">
        <property type="entry name" value="URACIL-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11264:SF0">
        <property type="entry name" value="URACIL-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00987">
        <property type="entry name" value="UreE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="Uracil-DNA glycosylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00130">
        <property type="entry name" value="U_DNA_GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uracil-DNA glycosylase-like" evidence="10">
        <location>
            <begin position="127"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="316"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="365"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="35"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="368"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="391"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7 8">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK4035383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="400" mass="43071" checksum="756EDA09751D4E57" modified="2024-10-02" version="1">MSTLKRKAGAAAGAEPKKAKQGSIMSFFGAPKPSPTAGGSAPNSAAAAAPEQAPLKFDKVKWAASLTPEQRKLLQLEIDTLHESWLALLKDELVTKEFLELKKFLDREAAAGKKVFPPREDIYSWSRHTPFPTVKVVILGQDPYHNHNQAHGLAFSVRPPTPAPPSLKNMYIALKNDYPTFTAPPNKAGLLTPWADRGVLMLNTCLTVRAHEANSHSNRGWERFTQKVIDLVAVRRTKGVVFLAWGTPAGKRVLKVDGQRHLVLKSVHPSPLSANKGFFTCGHFREANEWLAERYGAEGRVDWALVEAGSVLKAGDEKKGGGEGVKKEEGETGVKKEEGEKGVEGSMVKKVEAVVKVAAVAVAGGNAENKDAGKETGVGEKKKGVVKAEGDENAAPEVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SQV5</accession>
    <name>A0AAN6SQV5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Polymerase nucleotidyl transferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_46843</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854393">
        <property type="protein sequence ID" value="KAK4039739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SQV5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002934">
        <property type="entry name" value="Polymerase_NTP_transf_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01909">
        <property type="entry name" value="NTP_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042812364" description="Polymerase nucleotidyl transferase domain-containing protein" evidence="1">
        <location>
            <begin position="33"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Polymerase nucleotidyl transferase" evidence="2">
        <location>
            <begin position="22"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4039739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="268" mass="30162" checksum="BEA1443C992EBD33" modified="2024-10-02" version="1">MHPHHTTTLQNTLAHFSPNPAVLALLLAGSLAHGFATATSDVDVLVVLTEEAYAEQLRSGERTFVSTALATYPGGFVDAKYISLGFMREVAERGSEPARFAFEGARVVLDRIPPEEGVLGGVLERIVGYPVEGKRERVVRFRAQLDAWRWYCGEGLRKREGDGGYLLGLAVRKLVLFGGRLVLAENEVLYPFHKWFLRVLEGVERKPEGLMECVRRVLGEPSEENVEAFYELIKGWREWEESSNRWGPQFMVDTELTWMSGHTPVDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SR15</accession>
    <name>A0AAN6SR15_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">E3 ubiquitin-protein ligase HERC2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_47331</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854409">
        <property type="protein sequence ID" value="KAK4039125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SR15"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="100"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="158"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4039125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="268" mass="28670" checksum="9BF996BD2C956045" modified="2024-10-02" version="1">MVLYATGFNAWNQLQFESPGVDEPDDIASCTCVLREDSVDRIRPFFSYTRVHDGRHSLNQYPSISSLLSQDSPSHTFSSPPHITQLVVYETGFAALSSAGQVWTWGDERYTACLGREPTDDSPAATPGPVTDLDELPTGPITKLAAGGYILAALTAGKDLYCWGHAGRSPLTLDNLSDAPSPVVIDDKDILDVAIGEAHMLVLTADRAVYVLGANTNGQLGLPGVSSAKTWARIDLDAVLGKGEIVTGVAAGPRNSFLMVHKQPEECQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SR18</accession>
    <name>A0AAN6SR18_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_37041</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854413">
        <property type="protein sequence ID" value="KAK4038991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SR18"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05120">
        <property type="entry name" value="APH_ChoK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF48">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="73"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4038991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="298" mass="34674" checksum="CC7BCCADFC5B9920" modified="2024-10-02" version="1">MATRPTLPYYAPPELLPGPLPTVAEILASKRRISHEGQTPVVLVGEHYAVKYGVRTSIQEGESQLFVQQSTSIPVPKVYAFFQGDVPGYNFKISFIVMEYIPGTTLERAWDTLSASAKRDIVSQLRRHMDELRSIPSPGYYGGVWRQQIRDRDFERPSDGLPYPEPEITGPHETEEQLVEGMWRCLEKAFTRYEGGPARRERHLAYFRRHYHSVFKGHPSVFTHANFFPGNVMLRPDGSVVIIDWEHSGWYPTFWEYCGTMWLLDHESDWDELVYEVLDEYEAEMGWFVNHRETIFHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SR42</accession>
    <name>A0AAN6SR42_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_16960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854413">
        <property type="protein sequence ID" value="KAK4038993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SR42"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4038993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="82" mass="9069" checksum="2EE97B8D84AA767E" modified="2024-10-02" version="1">MARCVCGNDSQGRCGFVTRLIDCDRCDNRTGYRRCGGCTRGQRDVVLKCCGACRPAGKIKCLPCNGIGKREIKERCTRRHVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SR88</accession>
    <name>A0AAN6SR88_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">LicD/FKTN/FKRP nucleotidyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_36889</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854409">
        <property type="protein sequence ID" value="KAK4039128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SR88"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009100">
        <property type="term" value="P:glycoprotein metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009644">
        <property type="entry name" value="FKTN/MNN4/W02B3.4-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007074">
        <property type="entry name" value="LicD/FKTN/FKRP_NTP_transf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15407">
        <property type="entry name" value="FUKUTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15407:SF28">
        <property type="entry name" value="RIBITOL-5-PHOSPHATE TRANSFERASE FKTN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04991">
        <property type="entry name" value="LicD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042908844" description="LicD/FKTN/FKRP nucleotidyltransferase domain-containing protein" evidence="6">
        <location>
            <begin position="32"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="LicD/FKTN/FKRP nucleotidyltransferase" evidence="7">
        <location>
            <begin position="131"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="LicD/FKTN/FKRP nucleotidyltransferase" evidence="7">
        <location>
            <begin position="250"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="51"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4039128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="321" mass="36506" checksum="D24C445389358A1B" modified="2024-10-02" version="1">MRPLAALFSNHKVLLLLTVLLVLSAILSTAAVARGGGQPFSFYVQQKQEQQQQQTPLSQQTPSPQENQGQKALSEGQRALIPEYKYFQEAGGTLELAHYDARFFTAPIPYTTHRTILTHLIRSYLTTFASLNLETWLAHGTLLGWYWNGRIMPWDFDVDAQVSGTTLAILAEQHNGSVHTYTAHTNPTTGQEENRTYLLDVNPFATRVGWGRGENFIDARWIDVETGMFVDITGLVERDPRGQPGVWSCKNYHGYRPEELFPLRETEFEGVPAMVPWEYEGVLVGEYGEKSLVVTEWEGHRWDPDSKEWVKMNETETEEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SRB0</accession>
    <name>A0AAN6SRB0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_36320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854394">
        <property type="protein sequence ID" value="KAK4039697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SRB0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054208">
        <property type="entry name" value="DUF6914"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21858">
        <property type="entry name" value="DUF6914"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4039697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="186" mass="21113" checksum="ECCB80AB2993F275" modified="2024-10-02" version="1">MSNKNRIYFCLYYQQGQAGTAANPRVFHCALWVENKNSRGGGDYFHVRFHGRRPANRPDYPDGWTYESSIARGRPANWRHSNNIIGRILLGKLPAGITAQHINQVCAGVRLPREGTNQNCWDWTHWAIQAIQAQHWLPNFAWSGANGLAARAQAQGVAWYEGDRGRVPARHMWDIFGVESSHCVVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SRH6</accession>
    <name>A0AAN6SRH6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Pectin lyase fold/virulence factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">C8A01DRAFT_35571</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854377">
        <property type="protein sequence ID" value="KAK4040429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SRH6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046576">
        <property type="term" value="F:rhamnogalacturonan alpha-L-rhamnopyranosyl-(1-&gt;4)-alpha-D-galactopyranosyluronide lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024535">
        <property type="entry name" value="RHGA/B-epi-like_pectate_lyase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736:SF19">
        <property type="entry name" value="PECTIN LYASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12708">
        <property type="entry name" value="Pect-lyase_RHGA_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042830429" evidence="13">
        <location>
            <begin position="19"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase" evidence="14">
        <location>
            <begin position="41"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF12708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK4040429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="455" mass="49745" checksum="565117F3285FE5FE" modified="2024-10-02" version="1">MRGALLLSAWLAPADVLAQLPGPVGPKVDFQAKAKQKTCDITKYGAKADGKTDVGPAIMKAWRDCSNGGLVYIPPGTYAQKSDVVLKNGKSSAVQLDGVIERHYEGDYHMILVRGCEDFEFFSGNSKGAILGYGYQYLKDGKYGIRLVRFQNVRDFSVHGFAAIDFPSYYFVFDTVENGEIYNMIARGVVELGMTDGFDIWGKNIWAHDIEVTNGDECVTVKSPARNFLIENIYCNLSGGTAIGSLGRDTDVKDIHYRNLYMNEADACYLKTNGGDGSVSNVLWEKVIVHRGPYPLAVNAAWGPNRGSTGVQVSNLTFRDWHGEAIDPKRPVIRFDCDPNMPCHGVTLDNVNLWADNGDEVVWSCQHAYGSGACLRQAGSAKNRLRYQVAATVTEKPNHVAPTMPADFKKPPPSDAPFTIPPVPTTFYPGATPVSTLLNLKGSGGQNRRRCGGQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SS83</accession>
    <name>A0AAN6SS83_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_35326</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854372">
        <property type="protein sequence ID" value="KAK4040672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SS83"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051104">
        <property type="entry name" value="FAD_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720:SF3">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="303"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4040672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="451" mass="48888" checksum="8CB0F7C2AA986872" modified="2024-10-02" version="1">MSSPETSGDGLHIAIVGAGITGINLALGLQARNVSYTIYERSPGFREIGAGIGFSPNAERAMSSLNLEVFAAYRRIANANGEDYFQWVDGHKTGELIFKLHVGKDGFQGGLRSAFLEEWAKLIPPNAVQFNKHLDTITKLDSPKLLLHFKDGTTATADAVIGCDGIRSRVRQLLLSPSPISSSITRNNMNPKLPPSAHPTYTRKFCFRALAPMPAAISSLGRAKATTRFMYNGPGAHLITYPVGNSTLLNILAVISDPNPVWPHQHAQGRHTAPGTKAEAVAAFSGWCDTARAIVSLLPDGEEMDKWGVFDMAEHPAPYYARGRVCVAGDAAHATGPHLGAGGGMGIEDALVLAEVLGKVDGRVKRGDTAEGKGAVVERALEVYNEVRYARTQEVVQSTRAACDLFQWRDPEVGRDPERFGREIMEQFHRVWKYDIDGMVEEALAKLDADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SSD7</accession>
    <name>A0AAN6SSD7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_45864</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854368">
        <property type="protein sequence ID" value="KAK4040837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SSD7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000196">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000012">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF177">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="102"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="258"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="331"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="368"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="409"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="432"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="463"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="495"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="527"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="559"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="659"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="700"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="731"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="763"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="789"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="818"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="981"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1020"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1062"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1098"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1128"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1156"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="105"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="917"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="72"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="917"/>
            <end position="934"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4040837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1195" mass="127728" checksum="F07473E9D1621AEC" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SSI3</accession>
    <name>A0AAN6SSI3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_14737</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854356">
        <property type="protein sequence ID" value="KAK4041494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SSI3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4041494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="360" mass="41139" checksum="9F5012835AACCBF7" modified="2024-10-02" version="1">MQYLAQRRPRVAVEVLDLDHYHPLIRALSNVLSTDLAQVTYAQLIDGLPMVGTAWDMRAYLLFKEHPLVTHDKLCEGAMERAQVFCGTFDPVMLQFDSLVCGNPPPPVNTALDSDMRQVMQRYQDATPGSREFKMRLVELVAAAIHQIAILLFQSDDKLHSKEDIDDVVSWKKESEWVVFSPRHRVLQEYPDPRPTLFYHAAYVDYQQYPHGLADVAGYWAEDRIFGGVAVFDRGVSGTECNDIYFHSGRQDTTFRVWRLLDSQFSELAEFLLSEQPCTPPFPIIASYANKHRHDPWDAIALHHIFRDPWEREVPPTKPDDGRDVRSAGDYPEVDDMFDAVQAAVDRAVDESGEKGKSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SSI8</accession>
    <name>A0AAN6SSI8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_46017</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854371">
        <property type="protein sequence ID" value="KAK4040730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SSI8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="485"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="548"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="721"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="485"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="525"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="554"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="566"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="583"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="721"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="776"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="791"/>
            <end position="803"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4040730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="803" mass="86894" checksum="0E84578CC6A17B49" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SSJ4</accession>
    <name>A0AAN6SSJ4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Signal recognition particle subunit SRP14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Signal recognition particle 14 kDa protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_34942</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER).</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of a fungal signal recognition particle (SRP) complex that consists of a 7SL RNA molecule (scR1) and at least six protein subunits: SRP72, SRP68, SRP54, SEC65, SRP21 and SRP14.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SRP14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854365">
        <property type="protein sequence ID" value="KAK4041002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SSJ4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030942">
        <property type="term" value="F:endoplasmic reticulum signal peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.10">
        <property type="entry name" value="Signal recognition particle alu RNA binding heterodimer, srp9/1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003210">
        <property type="entry name" value="Signal_recog_particle_SRP14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009018">
        <property type="entry name" value="Signal_recog_particle_SRP9/14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12013">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 14 KD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02290">
        <property type="entry name" value="SRP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54762">
        <property type="entry name" value="Signal recognition particle alu RNA binding heterodimer, SRP9/14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0733">Signal recognition particle</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="110"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="115"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU368100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4041002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="137" mass="14898" checksum="4400CB2C2868D048" modified="2024-10-02" version="1">MGHLTNDEFFTKLADVFNTRKAKAHGAIYLTQKRLSYNTNQTPPSPENEEQDALADLHPSQPLPLLVRATNGKGKEHRAAKVKLSTVVQPDDLAGFYARYAEVCKAGMAALKPRDRTKRKAKAKKRKGGGGGVAPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SSY3</accession>
    <name>A0AAN6SSY3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-phytase</fullName>
            <ecNumber evidence="2">3.1.3.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_35055</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.8" evidence="2"/>
    <dbReference type="EMBL" id="MU854367">
        <property type="protein sequence ID" value="KAK4040883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SSY3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016158">
        <property type="term" value="F:inositol hexakisphosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF110">
        <property type="entry name" value="2-PHOSPHOXYLOSE PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4040883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="511" mass="56690" checksum="3FA86B7776733DE6" modified="2024-10-02" version="1">MTSLVPRAPYTDAELRQLYPDGLELQLVQVLMRHGERTPVSARFQNAGLQPWWPYCSSARQMRAAVLASTSTTADHAFDTLEWKRRVETFGDNDEPVVARGLGGQLDDVCDMGSLTDLGRQSTYKLGLRLRQHYVDRLGFLPPTISSADFLYLRSTPVPRALESLHQTFSALYPPSAREAGPDGKFPAPTILTRVPGDETLYPNDGNCRRFAALSRAFAQRAADRWNKTPDMEYLQKVYGKWMPPDTKVAVDSRPRLSGIMDTVNATLAHGPETKLPREFYDDKAQAIMEAISVEEWFAGYKESREYRMLGMGGLLGDIVGRMVGSVEQQTGRDGAHTLLKPTGQEDHSGRIRFGLSGCHDTTLAGVLASLGAYDTGRWPPFTSHLAIELFRESKIPAPLQEPAKGGWWASVFGAAGAPANIGRRPTTELTAGEKSKLDGYYVRIRYNDEPVTVPACRLPGNHLEADESFCTLAAFKSVVDKFTPTNWKQQCRMNRDRPALPTGEPEWAGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6STY0</accession>
    <name>A0AAN6STY0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PRISE-like Rossmann-fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_44911</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854347">
        <property type="protein sequence ID" value="KAK4042021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6STY0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08948">
        <property type="entry name" value="5beta-POR_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055222">
        <property type="entry name" value="PRISE-like_Rossmann-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32487">
        <property type="entry name" value="3-OXO-DELTA(4,5)-STEROID 5-BETA-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32487:SF4">
        <property type="entry name" value="SIRQ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22917">
        <property type="entry name" value="PRISE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRISE-like Rossmann-fold" evidence="1">
        <location>
            <begin position="10"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4042021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="418" mass="45434" checksum="A4609AE4094C59D0" modified="2024-10-02" version="1">MGGGGSNNHAIVFGASGLIGWALVDQLLSPYPHAGSFSKVTAVTNRPLNLSESHWPEPDSHRPDLQLVSGVDLRHGDAAALAECLKQEVNDIESVTHIYYLVFTAAEDDIEEVATNLRMFQNVIDAHNLLCPNLRFVTFPGGTRGYGIYMPGGTFTPPLTEDMVNNLPPSHAKTVVYPAYRELLNAASKGKKWTWCEVCPDAIIGFTPNGSQFSLALHWAQYLSLYAVNHGVGPNEASKPTTVEVPFPGNPASANALFTPVSSKTIARFMIYASLHPETCGGGRLFNIADDEAPCTLGEIWPQLAKWFGLVGVGPAENMQDQDRALNVSELPQTNLSLTPGEYVVKYRDTFAKHGAVNAASGGVGAGSRQLDSVGYWLTFDRQLSLKKLRETGFEGDKDPVQGWLESFEKFRAARLII</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SU31</accession>
    <name>A0AAN6SU31_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">C8A01DRAFT_44872</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854346">
        <property type="protein sequence ID" value="KAK4042098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SU31"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001009">
        <property type="entry name" value="Zinc finger protein 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000495">
        <property type="entry name" value="zinc finger protein 668"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF142">
        <property type="entry name" value="ZINC FINGER PROTEIN 384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="499"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="527"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="555"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="583"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="346"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="596"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="370"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="596"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK4042098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="633" mass="69000" checksum="3AB7D73A625192E2" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SU91</accession>
    <name>A0AAN6SU91_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_32647</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854329">
        <property type="protein sequence ID" value="KAK4043324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SU91"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="72"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4043324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="273" mass="30392" checksum="92747132EA60FCF0" modified="2024-10-02" version="1">MGQQAAAPQRTAPRRNDTTYSQTDATGGDTDTSDDSGTHSHTSDTFSLVGHVESVWSTNSSEDEPEPHATKADQLRCQLAETEQQLKTANDRDKLTATREACDKINNLLQRQRGQCMVQKRDLEQAQQTLAWTELQLAETAGDLEAADEEAEHSRWELKYMARELAKTKAERDGVRKFCHLASAYIGSLAAELDMHRVALVEAERDLLLRNHEIGRLKDGYAVGVMPFPPTPEGLQEAADAAMDSPELILALWKRFTDTMERLPGPWDADWGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SUJ8</accession>
    <name>A0AAN6SUJ8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">C2H2 type zinc-finger-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">C8A01DRAFT_13312</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the REI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854331">
        <property type="protein sequence ID" value="KAK4043117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SUJ8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041661">
        <property type="entry name" value="ZN622/Rei1/Reh1_Znf-C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040025">
        <property type="entry name" value="Znf622/Rei1/Reh1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13182:SF8">
        <property type="entry name" value="CYTOPLASMIC 60S SUBUNIT BIOGENESIS FACTOR ZNF622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13182">
        <property type="entry name" value="ZINC FINGER PROTEIN 622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12756">
        <property type="entry name" value="zf-C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="166"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="330"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="401"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="521"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="207"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="331"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="361"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="402"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK4043117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="553" mass="61836" checksum="62E9BB847EDDB028" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SUQ5</accession>
    <name>A0AAN6SUQ5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetylglucosaminylphosphatidylinositol deacetylase</fullName>
            <ecNumber evidence="2">3.5.1.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_12674</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PIGL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.89" evidence="2"/>
    <dbReference type="EMBL" id="MU854323">
        <property type="protein sequence ID" value="KAK4043834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SUQ5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000225">
        <property type="term" value="F:N-acetylglucosaminylphosphatidylinositol deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="entry name" value="LmbE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993:SF11">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL DE-N-ACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL DE-N-ACETYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="LmbE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4043834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="311" mass="33589" checksum="F2F5DF6E6889AC2B" modified="2024-10-02" version="1">MDWLLTLGVLAVVLPSLYVYTATVVSSRFPALRNKRICLLIAHPDDEAMFFAPAVMALARPETGNHVKILCLSSGMRPAPSHPHPCAASADKNGPMTGNADGLGETRKRELAKSGLILGLRKTDDVFVVDKPEFPDSMTATWDSANISSLLCSAFAPNLARSRNSDTAPEAAIDVLITFDAGGVSGHPNHISLYHGARAFVAALVAGKPGWQPPVDLYTLTTVPLGRKYTAFLDVLATLASWAIGADKADKKHPGGLVFLSGLAGDGSITTAWKAMVSAHKSQMVWFRYGWISLSRYMYINDLRLEKVKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SUS1</accession>
    <name>A0AAN6SUS1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Folliculin-interacting protein N-terminus-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_13562</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854335">
        <property type="protein sequence ID" value="KAK4042861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SUS1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042030">
        <property type="term" value="F:ATPase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028084">
        <property type="entry name" value="FNIP_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21634">
        <property type="entry name" value="RE13835P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21634:SF9">
        <property type="entry name" value="RE13835P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14636">
        <property type="entry name" value="FNIP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Folliculin-interacting protein N-terminal" evidence="2">
        <location>
            <begin position="116"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="440"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="640"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="749"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="979"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1033"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1107"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1220"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="118"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="644"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="673"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="704"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="787"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="807"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="868"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="987"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1038"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1051"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1112"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1132"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1147"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1231"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1252"/>
            <end position="1262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4042861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1262" mass="136042" checksum="B70D76B0006FF128" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SUU5</accession>
    <name>A0AAN6SUU5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">C8A01DRAFT_44008</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SecE/SEC61-gamma family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854332">
        <property type="protein sequence ID" value="KAK4043085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SUU5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.820">
        <property type="entry name" value="Preprotein translocase SecE subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00422">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023391">
        <property type="entry name" value="Prot_translocase_SecE_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008158">
        <property type="entry name" value="Translocase_Sec61-g"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001901">
        <property type="entry name" value="Translocase_SecE/Sec61-g"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00327">
        <property type="entry name" value="secE_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12309">
        <property type="entry name" value="SEC61 GAMMA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00584">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103456">
        <property type="entry name" value="Preprotein translocase SecE subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01067">
        <property type="entry name" value="SECE_SEC61G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK4043085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="70" mass="7799" checksum="4FF54ABED6BCBE3C" modified="2024-10-02" version="1">MADQVQEMLDVPREFLKDGIQFINRAQKPDRREFIKISQAVGVGFLVMGAVGYFVKLIHVPLNNILVGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SW95</accession>
    <name>A0AAN6SW95_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Adenylyltransferase and sulfurtransferase uba4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Common component for nitrate reductase and xanthine dehydrogenase protein F</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Ubiquitin-like protein activator 4</fullName>
        </alternativeName>
        <domain>
            <recommendedName>
                <fullName evidence="14">Molybdopterin-synthase adenylyltransferase</fullName>
                <ecNumber evidence="14">2.7.7.80</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="14">Adenylyltransferase uba4</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="14">Sulfur carrier protein MOCS2A adenylyltransferase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="14">Molybdopterin-synthase sulfurtransferase</fullName>
                <ecNumber evidence="14">2.8.1.11</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="14">Sulfurtransferase uba4</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="14">Sulfur carrier protein MOCS2A sulfurtransferase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="14" type="primary">uba4</name>
        <name evidence="14" type="synonym">cnxF</name>
        <name evidence="17" type="ORF">C8A01DRAFT_31447</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers urm1 and MOCS2A. Its N-terminus first activates urm1 and MOCS2A as acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to urm1 and MOCS2A to form thiocarboxylation (-COSH) of their C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards urm1 and MOCS2A. Subsequently, a transient disulfide bond is formed. Does not use thiosulfate as sulfur donor; nfs1 probably acting as a sulfur donor for thiocarboxylation reactions.</text>
    </comment>
    <comment type="function">
        <text evidence="13">Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers urm1 and mocs2a. Its N-terminus first activates urm1 and mocs2a as acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to urm1 and mocs2a to form thiocarboxylation (-COSH) of their C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as a nucleophile towards urm1 and mocs2a. Subsequently, a transient disulfide bond is formed. Does not use thiosulfate as sulfur donor; nfs1 probably acting as a sulfur donor for thiocarboxylation reactions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly + ATP + H(+) = [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly-AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:43616"/>
            <dbReference type="Rhea" id="RHEA-COMP:12159"/>
            <dbReference type="Rhea" id="RHEA-COMP:12202"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:90618"/>
            <dbReference type="ChEBI" id="CHEBI:90778"/>
            <dbReference type="EC" id="2.7.7.80"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly-AMP + S-sulfanyl-L-cysteinyl-[cysteine desulfurase] + AH2 = [molybdopterin-synthase sulfur-carrier protein]-C-terminal-Gly-aminoethanethioate + L-cysteinyl-[cysteine desulfurase] + A + AMP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:48612"/>
            <dbReference type="Rhea" id="RHEA-COMP:12157"/>
            <dbReference type="Rhea" id="RHEA-COMP:12158"/>
            <dbReference type="Rhea" id="RHEA-COMP:12159"/>
            <dbReference type="Rhea" id="RHEA-COMP:19907"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:61963"/>
            <dbReference type="ChEBI" id="CHEBI:90618"/>
            <dbReference type="ChEBI" id="CHEBI:232372"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.8.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="14">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="14">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="14">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">In the N-terminal section; belongs to the HesA/MoeB/ThiF family. UBA4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.80" evidence="14"/>
    <dbReference type="EC" id="2.8.1.11" evidence="14"/>
    <dbReference type="EMBL" id="MU854319">
        <property type="protein sequence ID" value="KAK4044393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SW95"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061605">
        <property type="term" value="F:molybdopterin-synthase adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061604">
        <property type="term" value="F:molybdopterin-synthase sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042292">
        <property type="term" value="F:URM1 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032447">
        <property type="term" value="P:protein urmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00757">
        <property type="entry name" value="ThiF_MoeB_HesA_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000033">
        <property type="entry name" value="Adenylyltransferase and sulfurtransferase MOCS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03049">
        <property type="entry name" value="MOCS3_Uba4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028885">
        <property type="entry name" value="MOCS3/Uba4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF102">
        <property type="entry name" value="ADENYLYLTRANSFERASE AND SULFURTRANSFERASE MOCS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="12 14" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 14" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9 14" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Rhodanese" evidence="16">
        <location>
            <begin position="349"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate; for adenylyltransferase activity" evidence="14">
        <location>
            <position position="218"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine persulfide intermediate; for sulfurtransferase activity" evidence="14">
        <location>
            <position position="413"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="89"/>
            <end position="93"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="150"/>
            <end position="151"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00043893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAK4044393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="460" mass="49194" checksum="6EF3D80FEEC02AE6" modified="2024-10-02" version="1">MGEASINGEPAAAKAAPNGCSRRLTDDEFDRYSRQMIVPGMGKEGQLRLINSRVLIIGAGGLGCPAAQYIAGAGVGTIGIIDGDVVETSNLHRQVGHATARIGMKKVDSLITHLRGLNPLPTYVSHPFHINPQNAAEVISQYDLVMDCTDNPVTRYLISDICVLVCKPLVSAAAIQKSGQLTVLNCPPTPQGLVDGKYAPCYRCCFRKPPPPSSMVSCGEAGIMGSVVGLMGVAQAGEAIKILASALHIPSPPAAGDTPERNLQQPTLLIYTYDLESAVGPYSFRALKMGGRKRNCFACGENSTLTLAGIRAGEPDYVQFCSVPTSSVSLPPEERITAAAYHAAKQKGELPEHILLDTREKEHFSFGSIEGAVNVPFGKLLMKAAAIKRDVSPASEILPLESEKTDVPIFVVCRRGLDSQETVEKLKELGLDNGGKRRIVDIMGGMKAWKEEVDPTFPFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SWJ6</accession>
    <name>A0AAN6SWJ6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">E3 ubiquitin ligase complex SCF subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_11949</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Essential component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Controls sulfur metabolite repression, probably by mediating the inactivation or degradation of the metR transcription factor.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the SKP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854317">
        <property type="protein sequence ID" value="KAK4044721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SWJ6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18322">
        <property type="entry name" value="BTB_POZ_SKP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000026">
        <property type="entry name" value="E3 ubiquitin ligase complex SCF subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016897">
        <property type="entry name" value="SKP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001232">
        <property type="entry name" value="SKP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036296">
        <property type="entry name" value="SKP1-like_dim_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016072">
        <property type="entry name" value="Skp1_comp_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016073">
        <property type="entry name" value="Skp1_comp_POZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11165">
        <property type="entry name" value="SKP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01466">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03931">
        <property type="entry name" value="Skp1_POZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028729">
        <property type="entry name" value="E3_ubiquit_lig_SCF_Skp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00512">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81382">
        <property type="entry name" value="Skp1 dimerisation domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="SKP1 component POZ" evidence="6">
        <location>
            <begin position="9"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="SKP1 component dimerisation" evidence="5">
        <location>
            <begin position="119"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00045385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR028729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4044721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="169" mass="19295" checksum="48BBC9D2F553CD8F" modified="2024-10-02" version="1">MSADKSVQKVTLTSNEGSTIEVDRVVAERSMLIKNLIDDLGDDAIANSPIPIPNVNDPVLRKVVEWCEHHRNDAAQSADDENDSRKKTTDIDEWDQKFMQVDQEMLFEIILAANYLDIKALLDVGCKTVANMIKGKSPEEIRKTFNITNDFTAEEEEQIRRENEWAEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P3S1</accession>
    <name>A0AAN6P3S1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_21589</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU855075">
        <property type="protein sequence ID" value="KAK4031164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P3S1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4031164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="89" mass="9707" checksum="C1B6C1261C5F2C7D" modified="2024-10-02" version="1" fragment="single">ASKSSYFEVIKQLLIARANVNTDPTREFTSRDSYLEVVKQLLIATANVNAGPTLKFSGRTALQVASGGSHLEVVKRLQEALNRLGFRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P4T0</accession>
    <name>A0AAN6P4T0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_41951</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854750">
        <property type="protein sequence ID" value="KAK4031600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P4T0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF11">
        <property type="entry name" value="AMP-DEPENDENT SYNTHETASE_LIGASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="1">
        <location>
            <begin position="158"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4031600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="557" mass="59609" checksum="4EB0140F75D5F658" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P4X1</accession>
    <name>A0AAN6P4X1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF8021 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_21021</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854696">
        <property type="protein sequence ID" value="KAK4031818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P4X1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058334">
        <property type="entry name" value="DUF8021"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26061">
        <property type="entry name" value="DUF8021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043039035" description="DUF8021 domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8021" evidence="2">
        <location>
            <begin position="155"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4031818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="292" mass="31595" checksum="C353F10BFCBE66C2" modified="2024-10-02" version="1">MPSLSTFFTSLTLSGLAAAACTRPFLQNITKAYVAAQKAGDPTLLTTLASGHPNLIYLENNRLALLSTGALSGPLNIDFTRSIHDPDECATFTEIIAATDPHPHVIHTRMVFDSTTQKASLIESIVTDQGDWLFNATGTLDLNAGETWEPIPEAERASREGVQALGDAYFDRFGNESVVVPWAEPCYRLEGGLPARGEMKDGECVMVWPSTIIIPYRRYVVDVTMGAVSLFIGFPGLDRTQGQAPMPDSHLFRVEGGKMKYCHTASACVVDGCGLNGTTFGRRGLKPVLLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P4Y8</accession>
    <name>A0AAN6P4Y8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sas10 utp3 c1d family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_41725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854694">
        <property type="protein sequence ID" value="KAK4031831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P4Y8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007146">
        <property type="entry name" value="Sas10/Utp3/C1D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13237:SF9">
        <property type="entry name" value="NEUROGUIDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13237">
        <property type="entry name" value="SOMETHING ABOUT SILENCING PROTEIN 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04000">
        <property type="entry name" value="Sas10_Utp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="132"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4031831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="375" mass="41163" checksum="657E52F53C0991D9" modified="2024-10-02" version="1">MAAPATLPALLDSLTKSLTTTLDAAPKLATVELPKDGISLLDVKNELLLSYLQNLVFLILLKLRHAKNADPDNATEEQNLDDLVVSKLVELRLYLEKGARPLEDKLRFQIDKVLRAADDAERDAKAAEEAAKANGHGSESESGSEEGESDAEEDEQDGAVDGRKITDLQHRPNLGGFQRPAAAVYAGKETGTSGVYRPPKIAPVVMPTTERREKGDRRPIKSATLDEFIADEMSTAPIAEPSIGTTIVNFGRKIKTASERRKEDERRDFEERNFVRLPKESKKDRAKRAKAEGGSRRMNFGGEEWRDLSEGVDRISRLTQGKGSGGGTKALLEKSRKRGIDTLDGPRGHGANMGERYQKRLKVLEGGRGTRGKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P533</accession>
    <name>A0AAN6P533_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_21071</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854707">
        <property type="protein sequence ID" value="KAK4031765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P533"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050432">
        <property type="entry name" value="FAD-linked_Oxidoreductases_BP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878">
        <property type="entry name" value="GULONOLACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878:SF97">
        <property type="entry name" value="ISOAMYL ALCOHOL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042855726" description="FAD-binding PCMH-type domain-containing protein" evidence="3">
        <location>
            <begin position="22"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="4">
        <location>
            <begin position="139"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4031765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="600" mass="64975" checksum="8F850C1B0168BC6E" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P5F7</accession>
    <name>A0AAN6P5F7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sugar transporter protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_51087</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854661">
        <property type="protein sequence ID" value="KAK4032019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P5F7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015798">
        <property type="term" value="P:myo-inositol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015791">
        <property type="term" value="P:polyol transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF9">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="281"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="347"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="403"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="35"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4032019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="507" mass="55673" checksum="5633564C07452400" modified="2024-10-02" version="1">MAAEILLPSASAKVDEARGFFDLEFKDPRYFTWVIVAFASIGGLLSGLDQSVILGATLSLPCSLGLDTRQNSLVNSAMPLGAVGGALILSPSNEWFGRRWSIIISCILYTIGAALEAGSINYGMIITIRVILGLGVGLEGGTVPVYVAETVERRLRRNLVSLYQFNIALGEVLGYAIAAMFLYVSGNWRYILGSSLVFSTIIFVGILFLPESPRFLMHQGRALDAYKVWKRIRGIETREARDEFFVMRVSVLYERQVVSESAVNKRFPWLDFFTVPQARRALIYANIMILLGQLTGVNAIMYYMSVLMSEIGFDDEKANYMSLVGSGSLLLGTIPAIFLIEKYGRRFWANTTLPGFFIGLVIIGASYQIPLDTNLQGAEACYLIGLILYVVPSEVYPTYLRSYGITTSDALLFLASFVVTYNFSAMQDAITRTGLTLSFHSGIAVTKDKTLEEIDLLFQRPTGEIVAENVRNICQAICDFVTGNWGSKSAAGGPAGKNLGQKETEIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P6D8</accession>
    <name>A0AAN6P6D8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_21212</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854751">
        <property type="protein sequence ID" value="KAK4031595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P6D8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4031595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="189" mass="21791" checksum="8D53E8F5480C64BD" modified="2024-10-02" version="1">MVNERDPKKRLPEVYLFKDDDWSFLSISVDVLEPVFRLAKRFEDRAPRIAKVVASLYYLLDHFRRQRSIYIDNIANPTINGPDFAGTSIFVGHQLPAVQPIAPPNTQSEIFLDRPQRQRRQPTRYRDGVDDLEIAGKDHSADFSDRQNLRTLRASLAVAIDKIDKYIATLEDSPAYWAAMILHPGLKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P6P6</accession>
    <name>A0AAN6P6P6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thiolase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_40912</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854588">
        <property type="protein sequence ID" value="KAK4032635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P6P6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF29">
        <property type="entry name" value="ASPERFURANONE POLYKETIDE SYNTHASE AFOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="3">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4032635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="215" mass="23013" checksum="ACFACA8482F37307" modified="2024-10-02" version="1">MPSRQAQVSLIQSAYRQGGCDPAVTGAIGEAIGAYRRSDKDGKLFVGSVKTNIGHLEGASGLAGLIKAVRSLEEGVIAPNIWFENGNPAIDFDGWHIQVPTEPTAWPASGLRRASINGFGYGGTNAHIIVDDAYHYLAENGLQGHHRTRPPPLSGAILSQLGPDRISDKAAKDRPIIFYLSAHEREAVENAAKSLSEYLVLPSFIAEGYPLENLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P701</accession>
    <name>A0AAN6P701_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alpha-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_40742</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing (1-&gt;4)-linked alpha-D-glucose residues with release of alpha-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.20"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.20" evidence="3"/>
    <dbReference type="EMBL" id="MU854574">
        <property type="protein sequence ID" value="KAK4032800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P701"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004558">
        <property type="term" value="F:alpha-1,4-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06595">
        <property type="entry name" value="GH31_u1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF89">
        <property type="entry name" value="ALPHA-XYLOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="6">
        <location>
            <begin position="193"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="7">
        <location>
            <begin position="508"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="634"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4032800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="843" mass="95621" checksum="6A6EF1B78CF643CE" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P703</accession>
    <name>A0AAN6P703_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_40652</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854565">
        <property type="protein sequence ID" value="KAK4032911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P703"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050897">
        <property type="term" value="F:cobalt ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015087">
        <property type="term" value="F:cobalt ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46494">
        <property type="entry name" value="CORA FAMILY METAL ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46494:SF1">
        <property type="entry name" value="CORA FAMILY METAL ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="576"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="608"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="513"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4032911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="652" mass="73442" checksum="F19531BA347E954A" modified="2024-10-02" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P7F8</accession>
    <name>A0AAN6P7F8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">1-phosphatidylinositol 4-kinase</fullName>
            <ecNumber evidence="2">2.7.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_41780</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19877"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.67"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.67" evidence="2"/>
    <dbReference type="EMBL" id="MU854703">
        <property type="protein sequence ID" value="KAK4031778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P7F8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004430">
        <property type="term" value="F:1-phosphatidylinositol 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05168">
        <property type="entry name" value="PI4Kc_III_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000035">
        <property type="entry name" value="Phosphatidylinositol 4-kinase PIK1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000016">
        <property type="entry name" value="PIK1p Phosphatidylinositol 4-kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021601">
        <property type="entry name" value="Phosphatidylino_kinase_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001263">
        <property type="entry name" value="PI3K_accessory_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057754">
        <property type="entry name" value="PI4-kinase_beta/PIK1_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049160">
        <property type="entry name" value="PI4KB-PIK1_PIK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF22">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21245">
        <property type="entry name" value="PI4KB-PIK1_PIK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11522">
        <property type="entry name" value="Pik1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51545">
        <property type="entry name" value="PIK_HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIK helical" evidence="7">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="6">
        <location>
            <begin position="697"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="188"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="276"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="485"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="214"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="229"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="507"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="534"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4031778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="992" mass="109375" checksum="9DA3425FECE2B5FA" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P7I5</accession>
    <name>A0AAN6P7I5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_41308</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the NRP synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854630">
        <property type="protein sequence ID" value="KAK4032257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05918">
        <property type="entry name" value="A_NRPS_SidN3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19545">
        <property type="entry name" value="FUM14_C_NRPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000015">
        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.30:FF:000003">
        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000005">
        <property type="entry name" value="Nonribosomal peptide synthetase 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000014">
        <property type="entry name" value="Nonribosomal peptide synthetase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056896">
        <property type="entry name" value="SIDD_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF3">
        <property type="entry name" value="SIDEROPHORE SYNTHETASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24895">
        <property type="entry name" value="SIDD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="742"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="1555"/>
            <end position="1631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4032257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="2111" mass="228379" checksum="9AA6C271792643C6" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P8G9</accession>
    <name>A0AAN6P8G9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ras guanine nucleotide exchange factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_39836</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854514">
        <property type="protein sequence ID" value="KAK4033708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P8G9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00155">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF354">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="64"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="8">
        <location>
            <begin position="731"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="7">
        <location>
            <begin position="911"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="318"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="519"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="613"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1161"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="542"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="623"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="651"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="672"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="695"/>
            <end position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4033708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1189" mass="130132" checksum="0636BC3BCDAAED7E" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P8R1</accession>
    <name>A0AAN6P8R1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_20117</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854568">
        <property type="protein sequence ID" value="KAK4032872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P8R1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043023204" description="Secreted protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4032872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="87" mass="9971" checksum="BA9B4E939F2ED6C2" modified="2024-10-02" version="1">MTHLIIVIASFLTTIKSTWELSRMVREKRAAKTPGLCCSLAHLSMMICFHLQDRPVLPKRVYQSGDTKSRSQCPKSTYHQPQHIFIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P9G6</accession>
    <name>A0AAN6P9G6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thioesterase-like superfamily-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_19762</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854541">
        <property type="protein sequence ID" value="KAK4033277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P9G6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.210">
        <property type="entry name" value="Acyl-CoA thioesterase, double hotdog domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049450">
        <property type="entry name" value="ACOT8-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052389">
        <property type="entry name" value="Sec_Metab_Biosynth-Assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049449">
        <property type="entry name" value="TesB_ACOT8-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38110">
        <property type="entry name" value="CHROMOSOME 23, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38110:SF1">
        <property type="entry name" value="THIOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13622">
        <property type="entry name" value="4HBT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20789">
        <property type="entry name" value="4HBT_3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA thioesterase-like N-terminal HotDog" evidence="1">
        <location>
            <begin position="33"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA thioesterase-like C-terminal" evidence="2">
        <location>
            <begin position="187"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4033277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="340" mass="37732" checksum="F295C19F23D68C1D" modified="2024-10-02" version="1">MDRSNAGDLAPFSKATEVDRLGSHTYSANLIDSFCIGTVPNGGYVASCILRAAGLHLAERGQKDVLNAHFQFLNRTETGPAVIIIEDVKLGRQLSTLHATLYQHALLPEPPWITQGSTRKEVAVYLTMADLSKERGISLPTAFTLQLHPPRPDFDALREDRDAHWARYELPGDSPLSYARSLRNCIYHDPRGGQQTKGVIDKWVRLASGENFTAASLGYVSDCWPYVVEAQRPSKQEAEERKRRGEGVPFAPGARFWYPTVVLNLEMKKALPAEGLEWLQLRIQSKQIKGGRFDLEVLLLDEHGDLVALSNHVNLILGSERNTAERTRGGGAEKGPLSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PAC9</accession>
    <name>A0AAN6PAC9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_38876</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854470">
        <property type="protein sequence ID" value="KAK4034668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PAC9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05251">
        <property type="entry name" value="NmrA_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF11">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="2"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4034668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="310" mass="33072" checksum="0588160F3FAE0001" modified="2024-10-02" version="1">MSQLLVIVGATGQQGGSVANFVLSDPVLSARYKVRALTRDTTKPAADALRAKGAEVVQADLEDPASLKAAFAGASTVFAATKTVYDEQAKARELRQSKDVADAAVAAGVQYLIYSTQVHCENVSGGKYPVAAYDSKAEAEAYIRSLPIKSAFYAPATFMQNLLAGMAPRPVPDQPAVYAIANIFAGDRPYPWLDVAADAGKFVGAILANPDKFAGKVLYAGSGMATMDEIAAKISAQTNKTVKYVLMSEEKFRAYLPPAAQDAIVNMFLFCSEHGYYGPDSERLVNESIAEVPYKLTSLEEYIAANVKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PAD8</accession>
    <name>A0AAN6PAD8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_20527</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854615">
        <property type="protein sequence ID" value="KAK4032387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PAD8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4032387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="359" mass="41062" checksum="2D9AE5C6A258A2D5" modified="2024-10-02" version="1">MPFSTSTYALPLDYHLWRPPPEPDKPPLPYRSGFQFTARRVKPPPPFLAEYTDLPTGPFSRFLKEARFPDDNFLRTTTLVDYCLSTSSKPLPCELLEETAAFEVIREISVRDGSGRGGSQVFTCRRQGWKESLVAKVYDPLYYPFADEDFPCFPNDVVAKAEHDFCLETAAYYQLDKKFGGSLIPKFHGSWLLKVPLKHRHRFVGFVLLEHLDGVPLNTLSPKRYTQEERLRVLAQTMEAEVELRFAGVMHEDIAPRNVICSGKDLSAKDLQVKIIDFNFVTIFPLLGDPAPCASELLPESPIEWFWGGWPGEMEEWVPEEWGTLEWNQWLKDTWGGSSRFKLVQEEHLTGVAEAVNNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PAF5</accession>
    <name>A0AAN6PAF5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_18470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854466">
        <property type="protein sequence ID" value="KAK4034764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PAF5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006376">
        <property type="term" value="P:mRNA splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050825">
        <property type="entry name" value="RBM42_RBP45_47-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640:SF10">
        <property type="entry name" value="TRNA SELENOCYSTEINE 1-ASSOCIATED PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640">
        <property type="entry name" value="TRNA SELENOCYSTEINE 1-ASSOCIATED PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4034764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="135" mass="15087" checksum="467F45444BC6772D" modified="2024-10-02" version="1" fragment="single">FATTGCSVSASAASNGSPVPNLARVFKLNWASGSGGGLVDRRDDRGPEFSIFVCWWDLGPEVNEFMLVSLFLSRFPSCKSAKIMTDAMTGQSRGRVRSLQRRIRPAAWPVMAPWTRRPTRPRMSWTSTRSWSSWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PAH5</accession>
    <name>A0AAN6PAH5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">PAP2 superfamily-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">C8A01DRAFT_48968</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the type 2 lipid phosphate phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854468">
        <property type="protein sequence ID" value="KAK4034720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PAH5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042392">
        <property type="term" value="F:sphingosine-1-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03388">
        <property type="entry name" value="PAP2_SPPase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969:SF28">
        <property type="entry name" value="DIHYDROSPHINGOSINE 1-PHOSPHATE PHOSPHATASE LCB3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969">
        <property type="entry name" value="SPHINGOSINE-1-PHOSPHATE PHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="84"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="554"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="10">
        <location>
            <begin position="114"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK4034720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="589" mass="63232" checksum="DD3956E9AFEC9155" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PAJ9</accession>
    <name>A0AAN6PAJ9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome b-c1 complex subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_41081</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the UQCRB/QCR7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854606">
        <property type="protein sequence ID" value="KAK4032477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PAJ9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045275">
        <property type="term" value="C:respiratory chain complex III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1090.10:FF:000001">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1090.10">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003197">
        <property type="entry name" value="QCR7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036544">
        <property type="entry name" value="QCR7_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12022:SF0">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12022">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX 14 KD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02271">
        <property type="entry name" value="UCR_14kD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000022">
        <property type="entry name" value="Bc1_14K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81524">
        <property type="entry name" value="14 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4032477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="125" mass="14306" checksum="C8872BD2C53B4925" modified="2024-10-02" version="1">MPVAPSLYNAAVKRPWLMNMLKPLAGWYANAAGYRQLGLKADDLLVEESEPVLKAVARLSPQESYDRIYRIRRATQLSLQQKVLPKNEWTKPEEDVPYLSPILEQVYAEGKEKQALDTLTILKKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PAT6</accession>
    <name>A0AAN6PAT6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Lethal giant larvae like, C-terminal-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_40642</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat L(2)GL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854565">
        <property type="protein sequence ID" value="KAK4032901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PAT6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045159">
        <property type="term" value="F:myosin II binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013905">
        <property type="entry name" value="Lgl_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10241">
        <property type="entry name" value="LETHAL 2 GIANT LARVAE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10241:SF25">
        <property type="entry name" value="TOMOSYN, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08596">
        <property type="entry name" value="Lgl_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="258"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Lethal giant larvae (Lgl)-like C-terminal" evidence="5">
        <location>
            <begin position="541"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4032901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1021" mass="109241" checksum="706E496EA7ABD41A" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PAU3</accession>
    <name>A0AAN6PAU3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vacuolar protein sorting-associated protein 54</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">C8A01DRAFT_39555</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854500">
        <property type="protein sequence ID" value="KAK4033995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PAU3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039745">
        <property type="entry name" value="Vps54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012501">
        <property type="entry name" value="Vps54_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019515">
        <property type="entry name" value="VPS54_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12965">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING 54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12965:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07928">
        <property type="entry name" value="Vps54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10475">
        <property type="entry name" value="Vps54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 54 N-terminal" evidence="11">
        <location>
            <begin position="280"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 54 C-terminal" evidence="10">
        <location>
            <begin position="815"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="144"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="244"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="534"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="615"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1064"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="311"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="157"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="176"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="546"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="1064"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1120"/>
            <end position="1133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF10475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK4033995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1133" mass="123352" checksum="29920238F3E82376" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PB03</accession>
    <name>A0AAN6PB03_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Glucose-6-phosphate isomerase</fullName>
            <ecNumber evidence="3 10">5.3.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">C8A01DRAFT_18274</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">In the cytoplasm, catalyzes the conversion of glucose-6-phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeogenesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11816"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="EC" id="5.3.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the GPI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.9" evidence="3 10"/>
    <dbReference type="EMBL" id="MU854458">
        <property type="protein sequence ID" value="KAK4035005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PB03"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004347">
        <property type="term" value="F:glucose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048029">
        <property type="term" value="F:monosaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051156">
        <property type="term" value="P:glucose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05015">
        <property type="entry name" value="SIS_PGI_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05016">
        <property type="entry name" value="SIS_PGI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1390.10:FF:000001">
        <property type="entry name" value="Glucose-6-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000004">
        <property type="entry name" value="Glucose-6-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00473">
        <property type="entry name" value="G6P_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001672">
        <property type="entry name" value="G6P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023096">
        <property type="entry name" value="G6P_Isomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018189">
        <property type="entry name" value="Phosphoglucose_isomerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035476">
        <property type="entry name" value="SIS_PGI_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035482">
        <property type="entry name" value="SIS_PGI_2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001211">
        <property type="entry name" value="PRK00179.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11469">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11469:SF1">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00342">
        <property type="entry name" value="PGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00662">
        <property type="entry name" value="G6PISOMERASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SIS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00765">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00174">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51463">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="6 10" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 10 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK4035005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="561" mass="60744" checksum="0AB121E50F61069E" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PB22</accession>
    <name>A0AAN6PB22_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ribonuclease P 40kDa subunit-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_48626</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854454">
        <property type="protein sequence ID" value="KAK4035124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PB22"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030681">
        <property type="term" value="C:multimeric ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000171">
        <property type="term" value="F:ribonuclease MRP activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013893">
        <property type="entry name" value="RNase_P_Rpp40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15396">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15396:SF1">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08584">
        <property type="entry name" value="Ribonuc_P_40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4035124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="356" mass="39625" checksum="060079A9DE498D83" modified="2024-10-02" version="1">MLSFNQPAVYQAAKCYVTYGVMGHLDPKQLPTKSKPWATLTSQDFVHRADLIIPQELLELVQDKLLKDKPAPEYKRVVMSLHDILSGEFFAEYIKKGDVLMLSGGRRGIDNVFALRSGTLTMFLDKEAYERAGLVGKPDGVKGKRGGKPRWVVEFDLTAPSMFPGKKGFDRLIYASKNALAEPMTWLFCNISSTTPDPDPLSRHSPTACTSNPSVSESIDAAMPELTPDISFLSSDGRADFEDFSTGLYEWLSLVRLQSPRIEVGDQIDPYLSRYQVPEGGKDGKLCKISWQGFLAPAWSRQTLVDSILALPHKAWFSFSTTTFSKGLAGDNTECTILRPPNSLGEYLMWEVKGHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PB52</accession>
    <name>A0AAN6PB52_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_48606</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854453">
        <property type="protein sequence ID" value="KAK4035169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PB52"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060213">
        <property type="term" value="P:positive regulation of nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045948">
        <property type="term" value="P:positive regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04329">
        <property type="entry name" value="RNAP_II_Rpb7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04462">
        <property type="entry name" value="S1_RNAPII_Rpb7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000043">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.120:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005576">
        <property type="entry name" value="Rpb7-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF4">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03876">
        <property type="entry name" value="SHS2_Rpb7-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88798">
        <property type="entry name" value="N-terminal, heterodimerisation domain of RBP7 (RpoE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase Rpb7-like N-terminal" evidence="8">
        <location>
            <begin position="8"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="7">
        <location>
            <begin position="78"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU369086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4035169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="190" mass="20930" checksum="BB42E40FDEC33092" modified="2024-10-02" version="1">MFFLHNLERRVTLHPSYFGRNMHELVTTKLVKDVEGTCAGDYYIIAIMDTFDVSEGRILPGSGLAEFTVGYRAVVWRPFKGEVIDAITQTVNPHGFFAQAGPLRLFVSSHLMPDEIQYDASATPAQFTNNADIVIEQGTHVRVKIIGLRTEVGEMWAIGSINGDFLGYVTPNHICGLPTGIGSRKKAVAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PB89</accession>
    <name>A0AAN6PB89_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Citrate transporter-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_39349</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854491">
        <property type="protein sequence ID" value="KAK4034177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PB89"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004680">
        <property type="entry name" value="Cit_transptr-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43302">
        <property type="entry name" value="TRANSPORTER ARSB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43302:SF5">
        <property type="entry name" value="TRANSPORTER ARSB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03600">
        <property type="entry name" value="CitMHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="175"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="216"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="253"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="341"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="371"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="534"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="629"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="675"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="domain" description="Citrate transporter-like" evidence="9">
        <location>
            <begin position="130"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="427"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="432"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="451"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="468"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="496"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4034177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="704" mass="76867" checksum="3DA105F25FC92639" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PBI7</accession>
    <name>A0AAN6PBI7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Beta-glucosidase cel3A</fullName>
            <ecNumber evidence="4">3.2.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Beta-D-glucoside glucohydrolase cel3A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Cellobiase cel3A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Gentiobiase cel3A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">C8A01DRAFT_39126</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="4"/>
    <dbReference type="EMBL" id="MU854481">
        <property type="protein sequence ID" value="KAK4034400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PBI7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000002">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1700:FF:000003">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF29">
        <property type="entry name" value="BETA-GLUCOSIDASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042938566" description="Beta-glucosidase cel3A" evidence="15">
        <location>
            <begin position="17"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type III-like" evidence="16">
        <location>
            <begin position="794"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="732"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="757"/>
            <end position="767"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00070030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00078013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00083231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00083611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAK4034400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="872" mass="94580" checksum="E436F428E0B20D3E" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PBL1</accession>
    <name>A0AAN6PBL1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Filamentation induced by cAMP/death on curing-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_38195</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854447">
        <property type="protein sequence ID" value="KAK4035350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PBL1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3290.10">
        <property type="entry name" value="Fido-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003812">
        <property type="entry name" value="Fido"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036597">
        <property type="entry name" value="Fido-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040198">
        <property type="entry name" value="Fido_containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13504:SF38">
        <property type="entry name" value="FIDO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13504">
        <property type="entry name" value="FIDO DOMAIN-CONTAINING PROTEIN DDB_G0283145"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02661">
        <property type="entry name" value="Fic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140931">
        <property type="entry name" value="Fic-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51459">
        <property type="entry name" value="FIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fido" evidence="3">
        <location>
            <begin position="175"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="261"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="265"/>
            <end position="272"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR640198-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR640198-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4035350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="359" mass="40396" checksum="1C9023D521E980A2" modified="2024-10-02" version="1">MIADHESLGLAANISKAIANALPQLRIRLSPELREEAYRQHFAADPPDIIDRIRITAQNSRCAITEPIEEAWWDPESLEAALASVVYGSNMIESAGSTLAITTQLCRAVFRGRTSDISIAIDETDPAYEEDLAHLRATNRPANHQHVVASRREIVQHAQALAYMVNHIVIATKPWSEQLILDIHRILHDGLDDDVEAGTYRTYEVAVKYEKPGQKEKQKLSLCMRARAVPGNTPTEDDPVAICIDPYTLAARYHHQFVNIHPFGDGNGRMSRIILNSLLLRYAGHISEIGLDVEEREEYIGIATRASRVFHSEDMEVEFEEHTGHRELARFILVKSKRGLERMWHWAAGKGEEDGEGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PBQ9</accession>
    <name>A0AAN6PBQ9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Spo7-like protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_17890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854444">
        <property type="protein sequence ID" value="KAK4035418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PBQ9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071595">
        <property type="term" value="C:Nem1-Spo7 phosphatase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006998">
        <property type="term" value="P:nuclear envelope organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005605">
        <property type="entry name" value="Spo7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28249">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN SPO7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28249:SF1">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN SPO7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03907">
        <property type="entry name" value="Spo7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="342"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4035418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="424" mass="47194" checksum="9FB10C7D8435CC2B" modified="2024-10-02" version="1">MADSLDSIVKGAPVTLPGQDPAKAAGGTTPIASAAAAAAPPTPGKPGDPLSHTPSSPSMIYLNLLILEASLRAQYLELRARRRHHTFFLSLLTLWTAFFGYALFFAPREDGVGVGGSVYWVVETTEHMCFLGGVITGLLVWATGIWERGVRWPRRWLAVSNRGLRAFNCKLVIMKRPWWKEALSTAGWFLTYGLFSNNGSSYRWVEPGLLREVDKEMNLSRESHPTVHVSNRDEEKGGHEEDLASGGDYVKLLLLAKPFSPTFRENWELYRAEYWEKENERRALLRAKTKGRDRKVGKQTRGWFWWLPERRAAVEKPAVVSNEKAHHPRHAAVASEHRRTRSGSASMRRGSMSSVHGSRPKLEAEEHPGVTRKSSTSSDASDKKRKKLAAGAKNRPRVESRSVTPEIPSPLAKETTPRSGSASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PCQ9</accession>
    <name>A0AAN6PCQ9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Patched family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">C8A01DRAFT_37860</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the patched family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854436">
        <property type="protein sequence ID" value="KAK4038217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PCQ9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008203">
        <property type="term" value="P:cholesterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015918">
        <property type="term" value="P:sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1640.10:FF:000008">
        <property type="entry name" value="NPC intracellular cholesterol transporter 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1640.10:FF:000029">
        <property type="entry name" value="Putative Patched sphingolipid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053958">
        <property type="entry name" value="HMGCR/SNAP/NPC1-like_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004765">
        <property type="entry name" value="NPC1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053956">
        <property type="entry name" value="NPC1_MLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032190">
        <property type="entry name" value="NPC1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00917">
        <property type="entry name" value="2A060601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45727">
        <property type="entry name" value="NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45727:SF2">
        <property type="entry name" value="NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22314">
        <property type="entry name" value="NPC1_MLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16414">
        <property type="entry name" value="NPC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12349">
        <property type="entry name" value="Sterol-sensing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0153">Cholesterol metabolism</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 16" id="KW-0732">Signal</keyword>
    <keyword evidence="14" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="12" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042870030" evidence="16">
        <location>
            <begin position="24"/>
            <end position="1277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="595"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="634"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="664"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="716"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="741"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="830"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1070"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1103"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1132"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1175"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1216"/>
            <end position="1239"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="17">
        <location>
            <begin position="592"/>
            <end position="766"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAK4038217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1277" mass="139837" checksum="B0B330EC5EF2FC79" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PDH0</accession>
    <name>A0AAN6PDH0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_39201</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854484">
        <property type="protein sequence ID" value="KAK4034326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PDH0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4034326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="397" mass="45539" checksum="22262119D4BF64EA" modified="2024-10-02" version="1">MEALPPELRLQILLSISDVADLKAVVHASPVFHQQYLLDRQKVLGRVLEGTLGGAFVEAYAVQASTCLDKPGGELLRPTVEQFLGEYRGFRLDPGAVLRQCTIEDLAGMAAFHQDAIQTLLEYCPAVFLSKFDTTTGTPLQVGDLSTTERTRFLRSLYRFQLFCILFSTKRPYYPPEGFSEEDVLTIFFGIFNPWEAEEVACISRIIETKYQRVFEAIKGDLDRDNPRFSDWDWPTTPPGSFYLNEERHLEVHIQGTMRRGLALFRQVLGTEDHEALVQLMQANIGWQEDPSLTRCLSSYVQSFRRTEAAELSAHDQMEVDSKKLRYSCDRVDAPPLAWVVLWRGEYSNWFGEVIPSSLQDWGHVFWDGRRLHLFGGRNAVVRERWAQDDDPRYTLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PDM0</accession>
    <name>A0AAN6PDM0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">T6SS Phospholipase effector Tle1-like catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_37995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854440">
        <property type="protein sequence ID" value="KAK4038098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PDM0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018712">
        <property type="entry name" value="Tle1-like_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840:SF1">
        <property type="entry name" value="TLE1 PHOSPHOLIPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09994">
        <property type="entry name" value="T6SS_Tle1-like_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T6SS Phospholipase effector Tle1-like catalytic" evidence="1">
        <location>
            <begin position="5"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4038098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="640" mass="72601" checksum="A3C1F373BE01BD62" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PDV0</accession>
    <name>A0AAN6PDV0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_18354</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854461">
        <property type="protein sequence ID" value="KAK4034928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PDV0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4034928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="148" mass="16249" checksum="1B3BC5B546BD5E3A" modified="2024-10-02" version="1">MDTPVSDQAFCSPSGIAAPSPPPPDMTEAAPQADNGQHQEGKKLATQIAKSTEVNNTTASEQASNGQTSRPPRNVKWVAVPPGMTEELRQAKNRQYWEDRKLADETAKITEFNKNITISDQTSHNQAVRPSSRRKKVSMFSSVVEEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PEK0</accession>
    <name>A0AAN6PEK0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Permease family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_49114</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854476">
        <property type="protein sequence ID" value="KAK4034532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PEK0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042907">
        <property type="term" value="F:xanthine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006042">
        <property type="entry name" value="Xan_ur_permease"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00801">
        <property type="entry name" value="ncs2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42810">
        <property type="entry name" value="PURINE PERMEASE C1399.01C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42810:SF2">
        <property type="entry name" value="PURINE PERMEASE C1399.01C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="72"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="211"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="275"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="340"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="427"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="455"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="487"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="526"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="569"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="599"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4034532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="609" mass="63907" checksum="A785CD4D5AABB2BB" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PFC6</accession>
    <name>A0AAN6PFC6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Mitochondrial carrier domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">C8A01DRAFT_38129</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Transport of phosphate groups from the cytosol to the mitochondrial matrix.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854445">
        <property type="protein sequence ID" value="KAK4035391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PFC6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035434">
        <property type="term" value="P:copper ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990547">
        <property type="term" value="P:mitochondrial phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000076">
        <property type="entry name" value="Mitochondrial phosphate carrier protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000131">
        <property type="entry name" value="Mitochondrial phosphate carrier protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044677">
        <property type="entry name" value="SLC25A3/Pic2/Mir1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 (MITOCHONDRIAL CARRIER PHOSPHATE CARRIER), MEMBER 3, LIKE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671:SF10">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="86"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="183"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="284"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00054508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK4035391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="386" mass="42474" checksum="D2751AC6BDE780F5" modified="2024-10-02" version="1">MTLYPNYDTLQNTFGSTYARGRPQTKPHASGPTPYQARPDLYPAYSVIDDAKNKAQKLGAEATREFEAASQKAQAKTGHIELYSGRYYAACTFGGLMACGLTHAAVTPLDLVKVRRQVDSKLYKGNFQAWGHIFRTEGLRGIFTGWGPTLLGYSAQGAFKYGWYEYFKKTYSDMAGPEAAYKYKTALYLSASASAEFLADIALCPFEAVKVRMQATIPAQYKGTLDGFSKITAAEGIGGLYKGLYPLWGRQIPYTMMKFASFETIVEMIYDRLPGSKADYSKSAQTGVSFVGGYLAGILCAIVSHPADVMVSKLNAYRKAGEGFGAVTTRIYKDIGFMGLWNGLPVRIVMIGTLTGLQWMIYDYFKIFMGFPTTGGAPPPQELKQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PFM1</accession>
    <name>A0AAN6PFM1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_46610</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854386">
        <property type="protein sequence ID" value="KAK4040038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PFM1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4040038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="271" mass="30605" checksum="29B6379402161A2F" modified="2024-10-02" version="1">MRDDSLAHSKLYFQLLQLLRIIPLWIRETRYDLEKLRNDCSGSIFNPIPSLNHQPFLATAGIVRQNWDEVLGRFQVLETELQRRIDAKTDEIRGLRDGLFSASGLQEAHKATSMNRYIIIFTTVTIFYLPPAFVTAVFSMDLLHDEKLAFLKSTYAATIVTASVVTYIVAFGLVLFVDRRKVVPYLIGRPQSLVPAFLLSGKGTAPSGMPTEITEKAWLENGQSGPWSGFLAAPAPTPRQRRKTGRFWSRQPWEMVYGLAANIAENNSEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PG16</accession>
    <name>A0AAN6PG16_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Pex12 amino terminal region-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">C8A01DRAFT_36697</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the pex2/pex10/pex12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854403">
        <property type="protein sequence ID" value="KAK4039330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PG16"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016562">
        <property type="term" value="P:protein import into peroxisome matrix, receptor recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025654">
        <property type="entry name" value="PEX2/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006845">
        <property type="entry name" value="Pex_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23350">
        <property type="entry name" value="PEROXISOME ASSEMBLY PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23350:SF4">
        <property type="entry name" value="PEROXISOME BIOGENESIS FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04757">
        <property type="entry name" value="Pex2_Pex12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Pex N-terminal" evidence="16">
        <location>
            <begin position="104"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="426"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="449"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="491"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAK4039330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="511" mass="56740" checksum="166111A8F5D578CB" modified="2024-10-02" version="1">MSDPDPKNNANGGTATAATNTHTHTFAQAQQRLAARRQAREADAAARLATQQSASQLRARIAATQSPLLRRLGASTLSLWDTISSREGTRPAFRVGQVDAELLDEELVELLRGQVGDALKYMGGGVGSSNSILHDWEAEISLALRAVLFKLTVWDHDATYGAALQNLKYTDARRDGPALVPPSRWQKSLYGLVTVGGRYLWAKWEDWLLEQDDGFEGPSPGVQRLSRWSSTLSTMHASAAFASFLVFLLHGRYRTLLDRVLRMRLAPPTSQVSREVSFEYLNRQLVWHAFTEFLLFVLPLVGINRWRRWLARTWRKTKKIMSTGAEGAGDEKKGEYSFLPERTCAICYQDQNSASSENEVMAAASSGVVGSAQTDITNPYEAIPCRCTYCFVCLTTRIEREEGEGWPCLRCGDLVKECKPWSGDVLEPEAKSPGTKTVVFADDVKAPSDGEEEDRGEEDSQVLVEEDLDRSLEDLRPQTPSVASDQAEGSEGSESEDYEVEEDEMGEDLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PGE3</accession>
    <name>A0AAN6PGE3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_47013</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854398">
        <property type="protein sequence ID" value="KAK4039525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PGE3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09630">
        <property type="entry name" value="CDH_like_cytochrome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1210">
        <property type="entry name" value="Cellobiose dehydrogenase, cytochrome domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015920">
        <property type="entry name" value="Cellobiose_DH-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF14">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16010">
        <property type="entry name" value="CDH-cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49344">
        <property type="entry name" value="CBD9-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="239"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="293"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="330"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="367"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="518"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="549"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="588"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="619"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="199"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4039525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="675" mass="73330" checksum="2B595BDC4E9EED92" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PGJ3</accession>
    <name>A0AAN6PGJ3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">leucine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Leucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">C8A01DRAFT_37909</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Leu) + L-leucine + ATP = L-leucyl-tRNA(Leu) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11688"/>
            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:9622"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78494"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.4" evidence="2"/>
    <dbReference type="EMBL" id="MU854438">
        <property type="protein sequence ID" value="KAK4038140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PGJ3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004823">
        <property type="term" value="F:leucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006429">
        <property type="term" value="P:leucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.740.10:FF:000001">
        <property type="entry name" value="Leucine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004493">
        <property type="entry name" value="Leu-tRNA-synth_Ia_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055416">
        <property type="entry name" value="RBD_LARS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00395">
        <property type="entry name" value="leuS_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45794:SF1">
        <property type="entry name" value="LEUCINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45794">
        <property type="entry name" value="LEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24810">
        <property type="entry name" value="RBD_LARS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="11">
        <location>
            <begin position="67"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="11">
        <location>
            <begin position="219"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="12">
        <location>
            <begin position="834"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="domain" description="Leucine--tRNA ligase RagD-binding" evidence="13">
        <location>
            <begin position="984"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF24810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK4038140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1121" mass="126273" checksum="315E44E10C275E2D" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PH55</accession>
    <name>A0AAN6PH55_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutathione S-transferase kappa 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_15275</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854367">
        <property type="protein sequence ID" value="KAK4040914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PH55"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001853">
        <property type="entry name" value="DSBA-like_thioredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051924">
        <property type="entry name" value="GST_Kappa/NadH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42943">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42943:SF13">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE KAPPA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01323">
        <property type="entry name" value="DSBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DSBA-like thioredoxin" evidence="2">
        <location>
            <begin position="5"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4040914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="266" mass="28604" checksum="5434C5ECFBF67EAF" modified="2024-10-02" version="1">MGGKIDCYVDIASLYSYLVFLELQKNSALLASHNVEVEFHPVLLGAINAGSGNRPPWTLPAKASYGTHDARRSVARHNPPPPISVPKDLMTAAKTVVPLRCLHYIKQHHPRATFLATLHYLFYLFWAPPNTDLTTVESVSRALAGVPSGFIGPSTFPGAGTGPGAKPGTETGEGTSGGGERLFTEAEARAIVDAARGEEMKAVLKDTTQEALERGAFGAPWLWVSDGRGRAEPFFGSDRFHFVYEFLGLPYRDVTLLPAGGGKGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2025-10-08" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PH94</accession>
    <name>A0AAN6PH94_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 20">Serine/threonine-protein kinase Tel1</fullName>
            <ecNumber evidence="5 20">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">C8A01DRAFT_16099</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17 20">Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Associates with DNA double-strand breaks.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 20">Chromosome</location>
            <location evidence="2 20">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 20">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 20">Belongs to the PI3/PI4-kinase family. ATM subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="5 20"/>
    <dbReference type="EMBL" id="MU854387">
        <property type="protein sequence ID" value="KAK4039990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05171">
        <property type="entry name" value="PIKKc_ATM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000019">
        <property type="entry name" value="Serine/threonine-protein kinase Tel1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038980">
        <property type="entry name" value="ATM_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044107">
        <property type="entry name" value="PIKKc_ATM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021668">
        <property type="entry name" value="TAN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37079">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE ATM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37079:SF4">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE ATM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11640">
        <property type="entry name" value="TAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01342">
        <property type="entry name" value="TAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14 20" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7 20" id="KW-0158">Chromosome</keyword>
    <keyword evidence="11 20" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 20" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16 20" id="KW-0539">Nucleus</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 20" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="15 20" id="KW-0779">Telomere</keyword>
    <keyword evidence="9 20" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FAT" evidence="23">
        <location>
            <begin position="1860"/>
            <end position="2463"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="22">
        <location>
            <begin position="2568"/>
            <end position="2879"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="24">
        <location>
            <begin position="2899"/>
            <end position="2931"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="184"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="419"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="691"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="2851"/>
            <end position="2885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="2873"/>
            <end position="2885"/>
        </location>
    </feature>
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        </source>
    </evidence>
    <sequence length="2978" mass="331883" checksum="969385C3E99A2DD7" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PHG5</accession>
    <name>A0AAN6PHG5_9PEZI</name>
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        <recommendedName>
            <fullName evidence="6">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_45684</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
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            <taxon>Sordariomycetidae</taxon>
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            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ZF_PHD_1"/>
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    </dbReference>
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        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
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            <end position="807"/>
        </location>
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            <end position="758"/>
        </location>
    </feature>
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            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
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        </location>
    </feature>
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            <end position="112"/>
        </location>
    </feature>
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        <location>
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        </location>
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        </location>
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    </feature>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK4041043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1269" mass="135151" checksum="D7C20F59C64012D5" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PHQ1</accession>
    <name>A0AAN6PHQ1_9PEZI</name>
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        <recommendedName>
            <fullName evidence="15">RING-CH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="13" type="ORF">C8A01DRAFT_46389</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
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            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    <dbReference type="Proteomes" id="UP001303115">
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
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        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
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        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46283">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MARCH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="150"/>
            <end position="173"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="422"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="RING-CH-type" evidence="12">
        <location>
            <begin position="20"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="28"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="363"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="379"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK4040230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="528" mass="57141" checksum="FE5500DCFF0F80B5" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PI56</accession>
    <name>A0AAN6PI56_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_14832</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854357">
        <property type="protein sequence ID" value="KAK4041409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PI56"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206:SF2">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE AUSG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="384"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4041409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="444" mass="50823" checksum="24AF72E2775B7AD6" modified="2024-10-02" version="1">MLDGWFHSHSDQAARVIGDAGEVIVLPPGLAHEMRNDPRLSFSGWIVKNFHAHLPGFEGFREGGRDSRIVQDVIMKDLTKHLNKVTEPLSEETALAVDEQYPASDDQAWHTAAPRETLLRVVARVSSRVFLGEEVCRNDDWLRVTREYTVDGFLAAEELRLWPAPMRALVHWFLPSCQRARADVAEARRIIGGVLEKRRLQKQRGEKAEHEDAIEWFEREARGRDYDPTVAQLTLSFAAIHTTTELVAQVMTDVCRNPEILVELRREMVQVLRDGGWKKTSLYNMKLLDSVIKESLRLKPTGIVSMRRIASDNVQFSDGTFIPKNSSIAVTSRNHWDPKVYDKPNEWDGGRFLRMRDTPGQEHQAQLVSTGPDHLAFGHGQHACPGRFFASNEAKVILIHLLLKYDWRLPEGAPAPRLLHYGWSIRTDPTTKLQYRRRRPEIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PI62</accession>
    <name>A0AAN6PI62_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Helix-loop-helix DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_15606</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854375">
        <property type="protein sequence ID" value="KAK4040543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PI62"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057072">
        <property type="entry name" value="bHLH_INO4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052207">
        <property type="entry name" value="Max-like/E-box_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX ZIP TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741:SF39">
        <property type="entry name" value="BHLH TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23181">
        <property type="entry name" value="bHLH_INO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="35"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="22"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4040543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="110" mass="12083" checksum="D37FD294AF8F374A" modified="2024-10-02" version="1">MANSPELSPSSSLSPQSAANRAEAEREGKRLTEEQKKVNHLTSEKKRRDNIRSGFDGLAGIVPGMEGRARSEGVVLFGAIDYVRRLMLERRAMIETLEGNGVTVDAELKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PIA9</accession>
    <name>A0AAN6PIA9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS antiporter QDR3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_16555</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854399">
        <property type="protein sequence ID" value="KAK4039509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PIA9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000396">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF4">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="402"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="446"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="491"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="523"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="555"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="586"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="91"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="306"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4039509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="630" mass="67793" checksum="C1761360017D6AD7" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PIW1</accession>
    <name>A0AAN6PIW1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Mitochondrial aspartate-glutamate transporter AGC1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Aspartate-glutamate carrier 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">C8A01DRAFT_34192</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Calcium-dependent mitochondrial aspartate and glutamate carrier. Transport of glutamate in mitochondria is required for mitochondrial transamination reactions and ornithine synthesis. Plays also a role in malate-aspartate NADH shuttle, which is critical for growth on acetate and fatty acids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homodimer (via N-terminus).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854351">
        <property type="protein sequence ID" value="KAK4041814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PIW1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015183">
        <property type="term" value="F:L-aspartate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005313">
        <property type="term" value="F:L-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043490">
        <property type="term" value="P:malate-aspartate shuttle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000004">
        <property type="entry name" value="Calcium-binding mitochondrial carrier protein Aralar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000552">
        <property type="entry name" value="Probable mitochondrial carrier protein ARALAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051028">
        <property type="entry name" value="Mito_Solute_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45678:SF9">
        <property type="entry name" value="CALCIUM-BINDING MITOCHONDRIAL CARRIER PROTEIN ARALAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45678">
        <property type="entry name" value="MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="EF-hand" evidence="16">
        <location>
            <begin position="100"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="16">
        <location>
            <begin position="172"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="15">
        <location>
            <begin position="342"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="15">
        <location>
            <begin position="440"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="15">
        <location>
            <begin position="538"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00059916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00073787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00082232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAK4041814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="699" mass="78444" checksum="C818D3ED26E2E132" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PJ45</accession>
    <name>A0AAN6PJ45_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fatty acid binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_34054</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ACBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854349">
        <property type="protein sequence ID" value="KAK4041943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PJ45"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000582">
        <property type="entry name" value="Acyl-CoA-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035984">
        <property type="entry name" value="Acyl-CoA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310:SF62">
        <property type="entry name" value="ACYL-COA BINDING PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310">
        <property type="entry name" value="ACYL-COA-BINDING PROTEIN, ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00887">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00689">
        <property type="entry name" value="ACOABINDINGP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47027">
        <property type="entry name" value="Acyl-CoA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51228">
        <property type="entry name" value="ACB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACB" evidence="3">
        <location>
            <begin position="4"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4041943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="104" mass="11335" checksum="A7C820BD2F819112" modified="2024-10-02" version="1">MVAQSEAFQKAVVDSKKLLAKPDNDELLEIYALYKIGTGEDFASAAKPGMFDLKGKAKYNAWKALVDDGLTPEEAQAKYAAKVEELKTKYGYDESKVPEAVGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PJH6</accession>
    <name>A0AAN6PJH6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Metallo-dependent phosphatase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_33778</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854345">
        <property type="protein sequence ID" value="KAK4042144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PJH6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000298">
        <property type="term" value="F:endopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006798">
        <property type="term" value="P:polyphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050126">
        <property type="entry name" value="Ap4A_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42850">
        <property type="entry name" value="METALLOPHOSPHOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42850:SF4">
        <property type="entry name" value="ZINC-DEPENDENT ENDOPOLYPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="3">
        <location>
            <begin position="147"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="479"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4042144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="504" mass="53955" checksum="0CB1B9ADD2238842" modified="2024-10-02" version="1">MAPPAVAQFLPGHRHGPSRSLLFLLLGGLTFLTLCLFTSHLPALQQLTSVSPFGASAGKSRMTSTGAAAPHHQGPSQDQVVLLDLIEHEKEKKLENVKMEYGTNKHPPFKDDPPLLVGDLPQEHIPSSSPASPTKGPDGENRTNGKRLVVVGDVHGQRAALKALLRKIGFDHKHGDHLVLAGDMVTKGPDSKGVVKLAMDIGASAVRGNQEDKVLAAAREIHRFSVDDDSRLGPEADGDGEGGAGKGDDDNGEAETEARRKDHARSVARSLSRAQLAWLRSLPIILRIGHLPDATSAPWNASTLAVVHAGLVPGVPLKKQDPWAVMNMRSLVYPRKGKGKKNKGKPHSRSNSPSDDTTPEEATTELDALTLAPDADAVAVPIDGRDGEPWSHAWNRHQNTLPPSTPHTLAIYGHDAKAGLQVTPKVDISPYYYTPSSSPSIRTIHGKQLTALVIEARSSSEGGGGVRHRIEQVDCADPEVRGMEDEEEEGEGEIASVRLMPEPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PJP2</accession>
    <name>A0AAN6PJP2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_34013</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854349">
        <property type="protein sequence ID" value="KAK4041907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PJP2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4041907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="292" mass="32842" checksum="58C24638A3B34144" modified="2024-10-02" version="1">MRWLNYLVCFIQRFFDHWDDATADDISDFESETRASIRQEILSLGTERCLLDHLAFKVYRAVMIQTTDGDEHRFVHEAEMPLRASGPPFVDFSVLLPALTGGGDERVVFIRYVRNCAKEYCSVDGWPATVSDSLDSKYPFFQLAVTDQGVTCPAWSVPLHPRIDVGEHIYGGDLQLVMKELSGLELQYDPTAHTVRAALPSADGDVMGGVEILSDNPMIVCRMQTAPNLLSFWVSEMAAKERIIPLSTFVSDHRAGLIERPAWTGMALRLYRQWVGEKTLMAKLGRARLPDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PK74</accession>
    <name>A0AAN6PK74_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heterokaryon incompatibility protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_15504</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854372">
        <property type="protein sequence ID" value="KAK4040651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PK74"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="21"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4040651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="618" mass="69287" checksum="7022FC2616283134" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PKG8</accession>
    <name>A0AAN6PKG8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">D-aminoacyl-tRNA deacylase</fullName>
            <ecNumber evidence="2 6">3.1.1.96</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_13807</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a D-aminoacyl-tRNA + H2O = a tRNA + a D-alpha-amino acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13953"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:10124"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59871"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:79333"/>
            <dbReference type="EC" id="3.1.1.96"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>glycyl-tRNA(Ala) + H2O = tRNA(Ala) + glycine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53744"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:13640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78522"/>
            <dbReference type="EC" id="3.1.1.96"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the DTD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.96" evidence="2 6"/>
    <dbReference type="EMBL" id="MU854338">
        <property type="protein sequence ID" value="KAK4042654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PKG8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051500">
        <property type="term" value="F:D-tyrosyl-tRNA(Tyr) deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.80.10:FF:000001">
        <property type="entry name" value="D-aminoacyl-tRNA deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.80.10">
        <property type="entry name" value="D-tyrosyl-tRNA(Tyr) deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003732">
        <property type="entry name" value="Daa-tRNA_deacyls_DTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023509">
        <property type="entry name" value="DTD-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00256">
        <property type="entry name" value="D-aminoacyl-tRNA deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10472:SF5">
        <property type="entry name" value="D-AMINOACYL-TRNA DEACYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10472">
        <property type="entry name" value="D-TYROSYL-TRNA TYR DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02580">
        <property type="entry name" value="Tyr_Deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69500">
        <property type="entry name" value="DTD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0820">tRNA-binding</keyword>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4042654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="161" mass="17676" checksum="8F92CA6A89B67C63" modified="2024-10-02" version="1" fragment="single">AILQRVLSASVTVDNEVVSKIGKGVLVFAAMAPGDTEKEAESLAAKVLKLKLWDDESEGRWKRNVRDINGEVLCVSQFTLLASTKKGNKPDFHGALGGEDAKRLYEYFYSKVQEGYSAERVKNGVFQAMMQVALVNDGPVTLEILAQPKQDKEETKTKAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PKQ1</accession>
    <name>A0AAN6PKQ1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_33163</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854336">
        <property type="protein sequence ID" value="KAK4042768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PKQ1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="299"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4042768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="312" mass="34102" checksum="4E8171B71A890117" modified="2024-10-02" version="1">MPSFDRFYASSPILAMPPQAAHQVSLGKSFLQHQILPPFSQPTSWRPQLVRTCTAAGRKRSRDEAAVNLDPPEKLVEAPVNKEPEDEWVYGPGMTLIKKSAGYVADAGSQSGTWVEERAAAEDARKTEAALLAQEQLAQSRPSLRSHKSQRLDMTTPPTTADERFPSRRSSPTREAINPITASSDSLAQPIVDDFTLHLGIGWSRISDDGHIQAAARGWARYIENHYPVTNVKILLESRGLQSYLVEAAEGYFLFAENLRQGRLVSATPDGALNNLKISPPVFDGPTIMDASESAKPLDSTAATTSTDMDMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PKR4</accession>
    <name>A0AAN6PKR4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_13826</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat CDC20/Fizzy family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854339">
        <property type="protein sequence ID" value="KAK4042587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PKR4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010997">
        <property type="term" value="F:anaphase-promoting complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990757">
        <property type="term" value="F:ubiquitin ligase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905786">
        <property type="term" value="P:positive regulation of anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000098">
        <property type="entry name" value="WD repeat-containing protein slp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033010">
        <property type="entry name" value="Cdc20/Fizzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056150">
        <property type="entry name" value="WD40_CDC20-Fz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918">
        <property type="entry name" value="CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918:SF8">
        <property type="entry name" value="FI02843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24807">
        <property type="entry name" value="WD40_CDC20-Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CDC20/Fizzy WD40" evidence="9">
        <location>
            <begin position="277"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="322"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="405"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="536"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4042587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="598" mass="64423" checksum="AD02EA7F4BDD72F9" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PL30</accession>
    <name>A0AAN6PL30_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Indoleamine 2,3-dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_15655</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the indoleamine 2,3-dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854376">
        <property type="protein sequence ID" value="KAK4040495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PL30"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033754">
        <property type="term" value="F:indoleamine 2,3-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000898">
        <property type="entry name" value="Indolamine_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037217">
        <property type="entry name" value="Trp/Indoleamine_2_3_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657:SF11">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01231">
        <property type="entry name" value="IDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140959">
        <property type="entry name" value="Indolic compounds 2,3-dioxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4040495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="478" mass="53666" checksum="841DE853F56F2535" modified="2024-10-02" version="1">MFINIGYIVLPVLCSVLAVLSAMSSWLKTLKHSALILSKFSLGKMATCKTSRERIKEVADLTEYHETAACLADLVRQDGAGSWPPRANHTHSTWPAALRPYKEIYHEMAPLLAAVNISLDDDVNRQRVTHFRSRFQQLLSERVNLGEVTQLLEAADAGRWDVFPRDVYNAFYSCIAWCRHAYRWGTIPAVKVAQLEKTVSLPPELTTPWTSLQSHFGLSSDAGNMMANLVLNFAAPPSGEYVYRINTGLPEEVTASEESFARVAHDMEALALPVYCDVVGAIVSFARGDLPACLARVRAVAAQLRPVLGSYYEKVHDGKIARSVWLSRVQGFYAWGAGREDPVSGKWEVFDGLSGNQVLLFQVLDAFLGMEPYLTREVLERNVPRLQREFCAAVGRHAFRKLLGDEGVEGRIREEMAEIVKRLRLFRSAHRTRAKFYLTVPAPERLPMTAGKSLLKADMEQSMQFLDQFMLSRLQQTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PMG1</accession>
    <name>A0AAN6PMG1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">PQ loop repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_13037</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854327">
        <property type="protein sequence ID" value="KAK4043467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PMG1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000005">
        <property type="entry name" value="PQ-loop repeat-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052241">
        <property type="entry name" value="SLC66/Scramblase_ANY1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14856:SF9">
        <property type="entry name" value="PQ-LOOP REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14856">
        <property type="entry name" value="PQ-LOOP REPEAT-CONTAINING PROTEIN 1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="258"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="271"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4043467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="280" mass="31071" checksum="C99946B675FC19A7" modified="2024-10-02" version="1">MGWLTTLSGYLTPAFLILSPVLSYSDQAYSMHRARSSAGFSLDIPLIMLVASLMRIFYYPGAKYDSALLVQSFIMVGMQVILLKVALDHRPAPYSKGGDAAVPFARVNESQRPFNFWQWRSPKPYWQFLLALFAGLVVFELLLAPVPAVYQSYSSLIGIVGLSVEATLPIPQILANMRSRSSKGFRVSVLVSWLVGDSMKMFWFFTSSTSIPWAFKICGMFQAACDSFLGVQYMMYGDSGVSKDHAAPNWQHELQPNGFTTASGHGIQPGRRTSTTEKTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PML9</accession>
    <name>A0AAN6PML9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WD-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_34687</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854360">
        <property type="protein sequence ID" value="KAK4041275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PML9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046925">
        <property type="entry name" value="WD-like_fungi"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20493">
        <property type="entry name" value="WD-like_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042934645" description="WD-like domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="WD-like" evidence="2">
        <location>
            <begin position="61"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4041275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="171" mass="17986" checksum="A73C6D0849765B01" modified="2024-10-02" version="1">MQLKTLTAAALLAALPAFAIPTAEVSVIVEDGLVLLDKFEIAEGTITTYAVDPAHAASTVQLTKRCGSNKVTCDGSHVPPFNTCQDLVSSIIDNSRVLASNPRSICLNRNGGNCCISWSKDIGNVVEQDLWSAAQKSLSQCVSEGKSAKASDVTINGQCLNQCLSNRASNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PN38</accession>
    <name>A0AAN6PN38_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AFG1-like ATPase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_12380</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AFG1 ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854321">
        <property type="protein sequence ID" value="KAK4044103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PN38"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005654">
        <property type="entry name" value="ATPase_AFG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040713">
        <property type="entry name" value="ZapE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12169:SF6">
        <property type="entry name" value="AFG1-LIKE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12169">
        <property type="entry name" value="ATPASE N2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03969">
        <property type="entry name" value="AFG1_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="535"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="544"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4044103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="562" mass="62921" checksum="ADB5712DB591C8A9" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PNR3</accession>
    <name>A0AAN6PNR3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DUF1772 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_14164</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the anthrone oxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854344">
        <property type="protein sequence ID" value="KAK4042211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PNR3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013901">
        <property type="entry name" value="Anthrone_oxy"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35042">
        <property type="entry name" value="ANTHRONE OXYGENASE ENCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35042:SF1">
        <property type="entry name" value="DUF1772-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08592">
        <property type="entry name" value="Anthrone_oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4042211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="173" mass="18270" checksum="A729758F83B21A62" modified="2024-10-02" version="1">MASHQDTTLRLTQGTALLLSTLSSGVSLTLSTFLVPRLLESPTPLMLTQWRRTYTRGASTVPFAAVAAAAGYIYLGLRTPGLGLCRSRLYLAAAALTVGIAPYTQLVMGGTNGELKRLEQRAAVEAEMVELPAEVIAEEERGAKALVDWWGVLNLGRTGLLVGGAVCALVATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PP41</accession>
    <name>A0AAN6PP41_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_13944</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854341">
        <property type="protein sequence ID" value="KAK4042406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PP41"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4042406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="181" mass="19499" checksum="97EB82093D8FC90C" modified="2024-10-02" version="1">MMESIQLAQMLADLSDLNAAESHAAVALVSANKTGPTAAPADPSRPPEQLPSRPGLRHHKRTASGGSAASTGSSFISRTASPAKFDKYGRRLLTPPNTRANSAYGSIPGTPRRDTEIDDDVDRANSLMALYEIRAKLKDQDNNRNLSKLREKIAALHAKQVQGEKKDGDAGRMKFSYPKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PQZ1</accession>
    <name>A0AAN6PQZ1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pre-mRNA splicing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_32477</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CWC26 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854328">
        <property type="protein sequence ID" value="KAK4043351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PQZ1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070274">
        <property type="term" value="C:RES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018609">
        <property type="entry name" value="Bud13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051112">
        <property type="entry name" value="CWC26_splicing_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31809">
        <property type="entry name" value="BUD13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31809:SF0">
        <property type="entry name" value="BUD13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09736">
        <property type="entry name" value="Bud13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="13"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="167"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="276"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="196"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="283"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4043351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="346" mass="37015" checksum="067AF4CF878372BD" modified="2024-10-02" version="1">MPSDKAAYLAAHYLTADSKPSSSSTKKRKRKQPPSSSGLLITDDDETGWGASSAPKNDAENDDAPLTIAGTTTDFRRTKKSGWKPLGGGAPPSTKDDAASSAAAAADAIIASAAAESAAAAAAEAAEDLQPDDTPQMSNGTLAGLQSAASLTAQLRRRQQLEAAELAELQAARANPTSNPEGGEEEIILRDATGRRVDASLRRAEARRQAAEAERAAKAKVDLLRGEVQTAQAQARRSQLEDAALMPLARNKDDVEMNEELKQAERWNDPMAEFLASSAPRGKGGKKTAGRRPVYKGGAPPNRYGIRPGYRWDGVDRGNGFEAERFKALNRRERDKGLEYAWQMDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PRV8</accession>
    <name>A0AAN6PRV8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="14">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">C8A01DRAFT_12384</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 14">Membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="14"/>
    <dbReference type="EMBL" id="MU854321">
        <property type="protein sequence ID" value="KAK4044159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006892">
        <property type="term" value="P:post-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF174">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE DNF3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 13 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 12 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 14" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="383"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="426"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1236"/>
            <end position="1258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1270"/>
            <end position="1290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1299"/>
            <end position="1323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1343"/>
            <end position="1363"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="17">
        <location>
            <begin position="96"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="16">
        <location>
            <begin position="229"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="18">
        <location>
            <begin position="1122"/>
            <end position="1370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="526"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="526"/>
            <end position="540"/>
        </location>
    </feature>
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            <begin position="563"/>
            <end position="580"/>
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            <position position="493"/>
        </location>
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            <position position="493"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
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        <location>
            <position position="493"/>
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        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
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            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
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        <location>
            <position position="495"/>
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        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
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            <position position="495"/>
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        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
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            <name>ATP</name>
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            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
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        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
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        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
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            <name>ATP</name>
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            <name>ATP</name>
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        <ligand>
            <name>ATP</name>
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            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
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            <dbReference type="ARBA" id="ARBA00004141"/>
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            <dbReference type="ARBA" id="ARBA00004308"/>
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            <dbReference type="ARBA" id="ARBA00022692"/>
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            <dbReference type="ARBA" id="ARBA00022723"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
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    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU362033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK4044159.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1460" mass="161416" checksum="15AB2CC24DC2B37B" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PTP6</accession>
    <name>A0AAN6PTP6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_31435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
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            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854319">
        <property type="protein sequence ID" value="KAK4044380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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            <begin position="1"/>
            <end position="60"/>
        </location>
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            <begin position="79"/>
            <end position="168"/>
        </location>
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        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <begin position="27"/>
            <end position="38"/>
        </location>
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            <begin position="97"/>
            <end position="108"/>
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            <begin position="118"/>
            <end position="139"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="EMBL" id="KAK4044380.1"/>
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    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="168" mass="18579" checksum="D5F828ADA4BBC99A" modified="2024-10-02" version="1">MSVSDNMEIDFSFEDSPEQEAEETQEAQEAQQAQQALEPYQFWPAQQVRPSRWTNPRDKRSEFNEFRARALQLRVHERHAPLLPSPLRNVVAASDLPDPDLSDAETVDDPLFNSTVRSDATSSDSDGSTSPASSTSDASNDSDEPGRRQDETEDADGSGAEDLVTSPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAN6SKV5_9PEZI</name>
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        <recommendedName>
            <fullName evidence="4">Fungal lipase-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="5" type="ORF">C8A01DRAFT_42175</name>
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        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a diacylglycerol + H2O = a monoacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15245"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. Lipase family. Class 3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854844">
        <property type="protein sequence ID" value="KAK4031364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SKV5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051218">
        <property type="entry name" value="Sec_MonoDiacylglyc_Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45856">
        <property type="entry name" value="ALPHA/BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45856:SF25">
        <property type="entry name" value="FUNGAL LIPASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal lipase-type" evidence="4">
        <location>
            <begin position="156"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00043996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00047591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00048461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4031364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="289" mass="30932" checksum="7D4CA41D134E5462" modified="2024-10-02" version="1">MEDEDKATPKPNLLGRVFKRHSVFPAKAVHVSGAVAGSVAGGVASTSVGLSVGLSGGSAGLLRSDNSAAMSRNIREASIELDKHLREIDSAEKESLSTDVISMSRWIEKQEAYANSSFPFSVLPEVTLPTADISNYDAWTMMADHLSMPLRVHLTVVAIRGTASIHDWMVNLNPGSCSDSPVEDKDEFLGKDKNGDNYHAHAGFLASAKEMLLRVCEEIAKAVNDFRNSRTQAVSGGLQLVFTGHSAGGAVAAMLYAHFMKPQAATSTELRFLNGVENRLHPSHQGSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SL32</accession>
    <name>A0AAN6SL32_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_41206</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854619">
        <property type="protein sequence ID" value="KAK4032366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SL32"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4032366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="337" mass="38326" checksum="C0F73F1D7BFF90B6" modified="2024-10-02" version="1">MPGETPAHIPGARRLGPGDLEGLWPQQKHDEIVNRVKYLVHDQLEEPPHIQRARQVLKQGSKNWRDASDEEIFFILNELPKPLFHSKFWGRGPQPPPSADYQELMSRIHKTELDFYGFDGESRSGQFLYMLRDAKHNPDPSSFYPRLKQAGITIDKVVHFTRRTATGGDVQLLSLPYKIEDRRELFVGDVARFLAGMQGRSGGMPHATHEMPPGDERSLEEGLMKVDGRTFVFDTTLNNSVLQAMQEADFKPAVIMREFTFWHDGADEDAEALGKVAWAQYSTTHWLTEYYDVYSRHPGSGFVACNPTIYIRKGRSLMHALKRSASNLVSRSNSRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SLM8</accession>
    <name>A0AAN6SLM8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_20963</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854684">
        <property type="protein sequence ID" value="KAK4031888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SLM8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4031888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="180" mass="19883" checksum="97D2C2D39FEA7626" modified="2024-10-02" version="1" fragment="single">MDCTPPELFEGQNLAYDASGNASVDIGGIEVPNPIWSTTFCDWFRLLVVHPFFKGSPALLAIVVQYAVKLRTNDRRRWPLENPTREGFLDDLAVGFRNPHPERSSRDLHSAVCRTFRQRGKELPVISSLFREMETSIRIAAVQSGAASAPFAPYMVATADIKGVVKALDDLHLGGVPAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SM91</accession>
    <name>A0AAN6SM91_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">V-type proton ATPase subunit G</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_41247</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the V-ATPase G subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854623">
        <property type="protein sequence ID" value="KAK4032325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SM91"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.2950:FF:000001">
        <property type="entry name" value="V-type proton ATPase subunit G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005124">
        <property type="entry name" value="V-ATPase_G"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01147">
        <property type="entry name" value="V_ATP_synt_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12713:SF11">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12713">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03179">
        <property type="entry name" value="V-ATPase_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="31"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4032325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="113" mass="12660" checksum="E01B7FE54E4F6971" modified="2024-10-02" version="1">MSAQNSAGIQTLLDAEREASKIVQKSREYRTKRVREARDEAKKEIEAYRANKEAEYKEFEAQHTQGNKAAEEEASKEADVKIDEIQAAGKKGQDKIIKDLLAAVFEAHPTPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SMA2</accession>
    <name>A0AAN6SMA2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_20143</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CHEK2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854570">
        <property type="protein sequence ID" value="KAK4032849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SMA2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF24">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="4">
        <location>
            <begin position="65"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="186"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="531"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="593"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4032849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="602" mass="66341" checksum="A2C49F05E81565E1" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SML1</accession>
    <name>A0AAN6SML1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_50162</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854545">
        <property type="protein sequence ID" value="KAK4033209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SML1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11060">
        <property type="entry name" value="CYP57A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF168">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4033209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="476" mass="53226" checksum="32EBA7F9F7E49279" modified="2024-10-02" version="1">MALSVGVLLGGLVTAYVLHTIWQWRRLAHVPGPFLAGFSKLGMAMEILQLRLPASLEQLSNKYGSLVRVGPNDLITDDPDVLRRMMAARSPYTRGPWYEALRVDPSKDNVLTLRDDAAHTARRAKILPGYSGKENLSMEGSVETQIAKLIELIETKYLSTGQDYRPMDWGLKAQYFTLDVISDLAWGRPMGFLEQDTDVYDYIKITTASVRVMLFVSTYPTLARALQSRFLRSILPKETDRVGFGPLIRIAKTVVAARFKPDAPDHRDMLGSFIRHGLDQDEASSESLLQIIAGSDTSATTIRSVMLNILSNPPVYQKLQAEIDKAIEMAKVSSPVKDAEGRQLPYLQAVIKEGLRVMPPASGGLFKQVPPGGDVIDGMFIPGGTQIGSSVMALHRSKKIYGPDAHIYRPERWLEAEGEQLARMNSTVDLIFHYGKYQCPGKGVAWMEFNKIFIEGIWLIEDLWLRVSRRNEERSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SMU8</accession>
    <name>A0AAN6SMU8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_40047</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854527">
        <property type="protein sequence ID" value="KAK4033479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SMU8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042853049" evidence="3">
        <location>
            <begin position="23"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4033479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="269" mass="29670" checksum="38AF47F62B7E613F" modified="2024-10-02" version="1">MALTNMKTCTLALGLLLAPAVALPIGNATAPSHNTTTEPNTTSAAIANERFLRDLKHPVIIATLSFFPGEAGGPQSKQPARVGQSGRRRGAPKKSFDYTTAAFLTVAAVVIVLLVITYRVVVHKSRALARQQNGDQDAEAASWPSPDRDELKNRQTTSWPAQYAGALYIRVYTHLDPNPLNTNNASLSFSWPANAQARPFYHHSRLANLRGITHRPYHYDVARKALSRHRPVLIAIHQQDTETLAAPWIAESRRMAEQTVMLMMKSYAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SMU9</accession>
    <name>A0AAN6SMU9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_20055</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854562">
        <property type="protein sequence ID" value="KAK4032940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SMU9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050432">
        <property type="entry name" value="FAD-linked_Oxidoreductases_BP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878:SF91">
        <property type="entry name" value="FAD BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G12070)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878">
        <property type="entry name" value="GULONOLACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042953252" description="FAD-binding PCMH-type domain-containing protein" evidence="3">
        <location>
            <begin position="22"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="4">
        <location>
            <begin position="149"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4032940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="636" mass="68165" checksum="86A9EED19318269A" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SN20</accession>
    <name>A0AAN6SN20_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_39832</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854514">
        <property type="protein sequence ID" value="KAK4033704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SN20"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="451"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="553"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="878"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="452"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="507"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="607"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="628"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="660"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="706"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="743"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="829"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="880"/>
            <end position="893"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4033704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="902" mass="90536" checksum="DA31010805426737" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SN95</accession>
    <name>A0AAN6SN95_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_49904</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854524">
        <property type="protein sequence ID" value="KAK4033523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SN95"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF13">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042851206" description="FAD-binding PCMH-type domain-containing protein" evidence="5">
        <location>
            <begin position="23"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="57"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4033523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="501" mass="54349" checksum="02563334AA00BD49" modified="2024-10-02" version="1">MLFLRATSLLSLFLSAIAPAYADTCSEVRDNTDIQVSSPLQLAYTAEQTEYWSASCIALKPSCIIFPRSAAEVAAVFRVLNTNNEKFAVKSGGHSPNNYYASVDGGPLISTQYLDHVLLDPTTGIIDVGPGNRLDGIAKKLQGTGWTFVGGRIGNTGVGGLILGGGLSYMSAQYGWSASSAISYEVVLANGTIVTTSATSHPDLFTALKGGGNNFGVVTNYKLQAHPQADVYGGNLVFLRTPSLDAALLRAVRDFTEHNTDNKAAIIVTAERTNVDLIDSWILFLFYDGPESAVPPGTFANFTSLKPLTNTLRTQTYADLMAGSNWVVLKGFQVQIGTETVPLPGAADAQDLLIDGIHAHWRNVSGTTLAVPGIVASIAYQPFPKRIAQAARERGADLIDVDADADRVIIELNYAFLLPIDYDKMEGKMRETYGGIRERVVAWQAEGKLPDVFLPVFMNYGFYRQDYWGRLKQASRELAREVAERVDPAGLFRDRTGGWKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SNF4</accession>
    <name>A0AAN6SNF4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_49708</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854511">
        <property type="protein sequence ID" value="KAK4033762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SNF4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="166"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="415"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4033762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="472" mass="49178" checksum="E873E28B0961E9EE" modified="2024-10-02" version="1">MYSAPYGYPNAAAGPIFNGAPPQQGAHLQPGPSPNQPQQQMMYNSQQFPMPGQPGAFPAGPNPALMGGGAGPAGMMQNAGMPHMAANGQMSFQAPFTTSPYAAGIPSSAAPQPQLPANFMMAGQMNPYQMNPGLPSQQPMMQRMLPAQQNPAGLSVSTPQRQFSHSQGTPTSSMPPQQPQFSTPQTQGTPQSQTPTTQHPPASIATPQTPTFPTDQGQPQANGTSTGSTPQSPATESRDKERMAVMLEINQELLYESIQLVNSRNELKKEQAAADAGGVKNGDVDYAEEEKLANLDYNQCMRRLQANLTYMFALADRKGKAQVPPSPAYLTPPPLNMQLKLKLPPSTPDDPVERPADPVADRNERYQLLKSLYRKLQSLYPGVDPKKEPPAQQQPAGGGGARQLPPGGGGGGGPNAVKAAAAPQNGMQASTPGGGGGGGLGGSNQNSPAPTPGQSQGTPLMAEAVAPGLLQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SNM4</accession>
    <name>A0AAN6SNM4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Prion-inhibition and propagation-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_39230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854485">
        <property type="protein sequence ID" value="KAK4034304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SNM4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1020">
        <property type="entry name" value="Prion-inhibition and propagation, HeLo domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029498">
        <property type="entry name" value="HeLo_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038305">
        <property type="entry name" value="HeLo_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37542">
        <property type="entry name" value="HELO DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14479">
        <property type="entry name" value="HeLo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0034">Amyloid</keyword>
    <keyword evidence="2" id="KW-0640">Prion</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prion-inhibition and propagation HeLo" evidence="1">
        <location>
            <begin position="5"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4034304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="628" mass="70219" checksum="3D38BB5E6668F506" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SNQ8</accession>
    <name>A0AAN6SNQ8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PIPK domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_39135</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854481">
        <property type="protein sequence ID" value="KAK4034409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SNQ8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016308">
        <property type="term" value="F:1-phosphatidylinositol-4-phosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.810.10">
        <property type="entry name" value="2-Layer Sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.800.10">
        <property type="entry name" value="Phosphatidylinositol Phosphate Kinase II Beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027483">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002498">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027484">
        <property type="entry name" value="PInositol-4-P-5-kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023610">
        <property type="entry name" value="PInositol-4/5-P-5/4-kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086:SF126">
        <property type="entry name" value="PIPK DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01504">
        <property type="entry name" value="PIP5K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00330">
        <property type="entry name" value="PIPKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51455">
        <property type="entry name" value="PIPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="PIPK" evidence="4">
        <location>
            <begin position="1"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="267"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4034409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="369" mass="41855" checksum="853962A75642DC58" modified="2024-10-02" version="1">MGRKEKIARSVVRAIVNNGADKRSNSPLALILALFSAFFSLYQLILRKVRPADFANLRRQHWDVSDDDYVQSFQADDDRSGEQALKAVGDMGFSGSTFYSTADQKYLVKSVPRHSEHSFFSEDLLTPYVQHMATNPRSLLVRICDFLAVSGPSIGRVFRSAPSHHIVMDNIMYGREEAKRQGEADWENWDLKPTSYFYPERDIAGGALTSEATKDQLADEFHDKITLRREQAEDFFSSLEADTKLLAEHNAVDYSLFLVRMRTPQQAAASMPPPTESTIGPTDSSPRPPSPPTWRTGVTSADGKYIFRASILDFFWAKHKVQPRVMTLLVKLWNLLVVKHGPMSITTTPDEYRERFLKLCRGIVEIKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SPA6</accession>
    <name>A0AAN6SPA6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_49113</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854476">
        <property type="protein sequence ID" value="KAK4034530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SPA6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4034530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="209" mass="23506" checksum="55EBA4B45D4B6054" modified="2024-10-02" version="1">MMFAIFFAFWRFMEIITLIPIMGMLAWFVNINLESNIMTPTYILLLFIVSVLALAWAVFTLFSYHRSSANAHFVSLIDLAFVGALIAGVYYLRFIARADCASIAPGSSVDIDFGIFGSARFNGVDVNISKTCGMLKACFALGIMNVVFFFVTAVMAWVHGGHAAKSEKRYVETRRRSHSRGHSQSRHRSRSGHRQGSRRSSHSHHRAYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SPY5</accession>
    <name>A0AAN6SPY5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Myosin tail region-interacting protein MTI1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_17904</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAK4035427.1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="AIM3_BBC1_C"/>
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    </dbReference>
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    <dbReference type="PANTHER" id="PTHR45929:SF6">
        <property type="entry name" value="SH3 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_2G10320)"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="AIM3_BBC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="PRICHEXTENSN"/>
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        <property type="entry name" value="SH3DOMAIN"/>
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        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="41"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="257"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="473"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="82"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="113"/>
            <end position="125"/>
        </location>
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        <location>
            <begin position="126"/>
            <end position="190"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
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            <end position="211"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
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            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="294"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="316"/>
            <end position="326"/>
        </location>
    </feature>
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        <location>
            <begin position="347"/>
            <end position="359"/>
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        <location>
            <begin position="397"/>
            <end position="408"/>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="425"/>
            <end position="442"/>
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            <end position="692"/>
        </location>
    </feature>
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    </feature>
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    </feature>
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        <location>
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            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="766"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="802"/>
            <end position="811"/>
        </location>
    </feature>
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        <location>
            <begin position="825"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="865"/>
            <end position="874"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4035427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1174" mass="125927" checksum="41C3DEB8F081B09F" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SQG7</accession>
    <name>A0AAN6SQG7_9PEZI</name>
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        <recommendedName>
            <fullName evidence="6">RNA polymerase II subunit A C-terminal domain phosphatase</fullName>
            <ecNumber evidence="6">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_37565</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">This promotes the activity of RNA polymerase II.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 6">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
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            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
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            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
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            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="6"/>
    <dbReference type="EMBL" id="MU854427">
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Fcp1"/>
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        <property type="entry name" value="FCP1_dom"/>
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        <property type="entry name" value="FCP1_euk"/>
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        <property type="entry name" value="HAD-like_sf"/>
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        <property type="entry name" value="FCP1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNA POLYMERASE II CTD PHOSPHATASE"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR23081:SF36">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT A C-TERMINAL DOMAIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="158"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="8">
        <location>
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            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
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            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="400"/>
            <end position="433"/>
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    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="892"/>
            <end position="915"/>
        </location>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="593"/>
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        </location>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
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        <location>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="726"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="784"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="859"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="903"/>
            <end position="915"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4038510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="915" mass="100966" checksum="43C8F2A704E0A3FA" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SR27</accession>
    <name>A0AAN6SR27_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HotDog domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_16932</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854412">
        <property type="protein sequence ID" value="KAK4039021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SR27"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052061">
        <property type="entry name" value="PTE-AB_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260:SF3">
        <property type="entry name" value="THIOESTERASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_7G03960)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260">
        <property type="entry name" value="UPF0644 PROTEIN PB2B4.06"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="2">
        <location>
            <begin position="169"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4039021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="252" mass="27163" checksum="56607877D298B745" modified="2024-10-02" version="1">MRNPGAQQPNSNPNPTQQQQQHHDNQTAIITNKTNRRHPGGSSPPEAHNQPIADPLAHFLAIPWTARLLTDPSAFGIVVSDRRPLASGEKQFVRGVLNGEATVRACVTFLVRVPPSPSSNGSGGGIGLLSKSKALLQGGGPQDGEDPEKPFLLFNALLDLGEGMCGFKGMLHGGAVVVLLDETMCAAANNQCDYTFTATMTTSFLSPVKLPGPVIVRSRVVRKQGRKIFVRGAIEDGDGEFYESRELYWQHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SR89</accession>
    <name>A0AAN6SR89_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_36341</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854395">
        <property type="protein sequence ID" value="KAK4039637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SR89"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13577">
        <property type="entry name" value="SnoaL_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="1">
        <location>
            <begin position="29"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4039637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="241" mass="27325" checksum="2594E0BF6BAE8EBE" modified="2024-10-02" version="1">MTSPVDPHSKCYSHINGTRDELSDRLAVSELCKGWPVYRDSSEWKNYRDLFAEEATVWTTWSGPRSVDDFIAISKAGKKKGVFIMHRECGTLVELNSCNNRAIGKMKATITHRFKFDPSTGGHGASPATETAEFDVDCDCRFIFFCEKNPATNQWKAKYVKLFYEKDKVVPVDGITAPKFAKEELEKIPAGYKYLGAAQARLGYQIDLDLPTAGGELFGRMYGEMEKWLDGKPVDLFWEYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SRB9</accession>
    <name>A0AAN6SRB9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_47296</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854407">
        <property type="protein sequence ID" value="KAK4039218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SRB9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053226">
        <property type="entry name" value="Pyrrolopyrazine_biosynth_F"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48419">
        <property type="entry name" value="SULFOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48419:SF1">
        <property type="entry name" value="SULFOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4039218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="351" mass="39269" checksum="56BC1A3D2BA146B1" modified="2024-10-02" version="1">MSNKPIFVATHPRACSTAFERVFMTRRDILRCVHEPFGDAFYFGPERLSERYEHDEAARTSSGFASTTYKDVIETLLHPTGSEGKRLFIKDIAHYLLPPDHKPASLAPSLDTHKTTTNGTTNGTHTNGNGTQPHANPTVVPTSLLRNFHFTFLIRHPRRAIPSYYRCTIPPLSSKTGFHHFMPNEAGYDELRRLFDYLLQEGIITTQGQQTKQNGTNGTLLSNGTGASSGAGGVKVTVVDADDLLDMPAEVVRAFCEDVGIDYHDGMLKWEDEAGQQLAVEAFEKWNGFHDDAIGSTELRARVHAKKTPTEEEEDAEWRNKYGEEGQRVIRACVDANVADYEYLKSFAMRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SRF6</accession>
    <name>A0AAN6SRF6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_16496</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854398">
        <property type="protein sequence ID" value="KAK4039545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SRF6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4039545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="519" mass="56301" checksum="CCD3EF0A4BF1EAD0" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SRI0</accession>
    <name>A0AAN6SRI0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_36666</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854402">
        <property type="protein sequence ID" value="KAK4039368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SRI0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="295"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4039368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="310" mass="37005" checksum="6AF772F8CCC7D7BC" modified="2024-10-02" version="1">MPRARRYEIDYDELHYDDIDYDDLSDDDAPDGIEYDVNLPPTFSHNLKFRLAVEEDREALEEISMYAVTPSDGSIHGHQLACVPEEYWDEFPRRMEMITKNDFFTCVVAEFVGQGFRIPDGTILGYTVWGWAEYTKDDDGGTTVKMGMLPRVFELWDKYLADSKKPTDDHEYRPRVVQRRVPPRPEHEGRRRTRVGRRREHCMWILQDMEWDCRLHPRDIEQHLIGWGCNIADRERIRLAVTWPWENTDEFERQGFDVRDYDDHSNYRVRDMYGFVQFLEMVKMRRRPRRVAEGNDNANANNNANNNVQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SRL5</accession>
    <name>A0AAN6SRL5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">C8A01DRAFT_15588</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DEAD box helicase family. DEAH subfamily. DDX15/PRP43 sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="MU854374">
        <property type="protein sequence ID" value="KAK4040549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SRL5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17973">
        <property type="entry name" value="DEXHc_DHX15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000007">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001148">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15/PRP43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000003">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044756">
        <property type="entry name" value="DHX15_DEXHc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF109">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="105"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="295"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="11"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00055599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK4040549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="762" mass="86669" checksum="1C40DBCC672A3E1A" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SS46</accession>
    <name>A0AAN6SS46_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7735 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_35882</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854384">
        <property type="protein sequence ID" value="KAK4040101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SS46"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056637">
        <property type="entry name" value="DUF7735"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24870">
        <property type="entry name" value="DUF7735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042813418" description="DUF7735 domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7735" evidence="2">
        <location>
            <begin position="51"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4040101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="234" mass="24411" checksum="D08FA4C39721FEFD" modified="2024-10-02" version="1">MRFNVFLGGLAALTAAAGVSARYLADSPAATITPDPLLAARQATPTTTMSVSRSTLTPDPWQCITENITQYFDVPKPTGNVFDAIASYNNEVNKECLATAVGYEKRSCTMSSPTSWCGFTTAAPADVLSSYSTYVSGVVSFWTAKSATMSILSTSCAVAWGRFHEADHEWVRIATAHADCYLAAHPQTRTGTEGPTATASATTTTSQANVVRRGPAAEAIALVSAGLAALANAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SSF1</accession>
    <name>A0AAN6SSF1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]</fullName>
            <ecNumber evidence="3">1.3.1.124</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_34587</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a (2E,4E)-dienoyl-CoA + NADPH + H(+) = a 4,5-saturated-(3E)-enoyl-CoA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:45912"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:85101"/>
            <dbReference type="ChEBI" id="CHEBI:85493"/>
            <dbReference type="EC" id="1.3.1.124"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a (2E,4Z)-dienoyl-CoA + NADPH + H(+) = a 4,5-saturated-(3E)-enoyl-CoA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:61892"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:85099"/>
            <dbReference type="ChEBI" id="CHEBI:85493"/>
            <dbReference type="EC" id="1.3.1.124"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.124" evidence="3"/>
    <dbReference type="EMBL" id="MU854358">
        <property type="protein sequence ID" value="KAK4041389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SSF1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008670">
        <property type="term" value="F:2,4-dienoyl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05369">
        <property type="entry name" value="TER_DECR_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045017">
        <property type="entry name" value="DECR2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43296">
        <property type="entry name" value="PEROXISOMAL 2,4-DIENOYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43296:SF2">
        <property type="entry name" value="PEROXISOMAL 2,4-DIENOYL-COA REDUCTASE [(3E)-ENOYL-COA-PRODUCING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00026117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4041389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="318" mass="32858" checksum="4A6F00234A1E2483" modified="2024-10-02" version="1">MSVPKSDYLSNVWANGIFANRVLFITGGAGSIGSAQTRALVHLGADACIVGRNTEKTEAAAREIAKVRNGARVIGIGGVDVRDFDALKAAADRCVKELGAIDYVVAGAAGNFVAPISALSPNAFKTVIDIDTIGTFNTIKATIPYLVDSAARNPNNPSGSDSLTGGRFVAVSATFHYTGMPLQSHVSAAKAAIDSLVASLSLEYGPLGITANCVAPGAIEGTEGMERLASNLVSKSDKDKGVPSGRWGTVRDIADATVFLLSEAGSYVNGTTLVVDGAGWRRQGGLGVGLDPGMVYPDYLLTGVVSRNLKDGRRNGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SSF9</accession>
    <name>A0AAN6SSF9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_46105</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854373">
        <property type="protein sequence ID" value="KAK4040640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SSF9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF3">
        <property type="entry name" value="C6 FINGER DOMAIN TRANSCRIPTION FACTOR DBAA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="26"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4040640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="539" mass="60037" checksum="BEE8ACF7D59A9AE9" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SSZ2</accession>
    <name>A0AAN6SSZ2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Short chain dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_45840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854367">
        <property type="protein sequence ID" value="KAK4040913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SSZ2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051935">
        <property type="entry name" value="HSDL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42808">
        <property type="entry name" value="HYDROXYSTEROID DEHYDROGENASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42808:SF4">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4040913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="313" mass="33624" checksum="97F7AB7D42C74CFB" modified="2024-10-02" version="1">MTSTSTRQVALVVGASRGIGRQIAIDLAKEGYAVVVAAKSTTPEADLAKLSPFPPDPNSPKSTITTVAREITLAGGEATAIPVDTTSYASIQQLTYARLDVLIYNSGAIWWAPVAATPMKRFQLMQRVNVEGLYGAVQEALPHLKRQDPRGGGPKRIVVVCPPIYSRFFRGKTAYAMGKVGMSVMVKGLGVDFEREGLVEGGVGVGGLWPAVAIESAATEQFTRKDPSYAKDLRKSTIFSDAVLAMLKAPASVMNGQLELDEDFLRKQAGVTDFSKYSVIPGSSPRRIMPAELPDLTVKEQDDEGMRTDSSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6STE4</accession>
    <name>A0AAN6STE4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_34136</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854350">
        <property type="protein sequence ID" value="KAK4041887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6STE4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4041887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="50" mass="5801" checksum="09ADDCA09F0B97EA" modified="2024-10-02" version="1">MSWRYNVKAIYWRYIRNRAVIEMVDNADTAEGEDDGRDRAGRAVGDAFYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6STJ4</accession>
    <name>A0AAN6STJ4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Feruloyl esterase C</fullName>
            <ecNumber evidence="11">3.1.1.73</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Ferulic acid esterase C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">C8A01DRAFT_44935</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 11">Involved in degradation of plant cell walls. Hydrolyzes the feruloyl-arabinose ester bond in arabinoxylans, and the feruloyl-galactose ester bond in pectin. Active against paranitrophenyl-acetate, methyl ferulate and wheat arabinoxylan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>feruloyl-polysaccharide + H2O = ferulate + polysaccharide.</text>
            <dbReference type="EC" id="3.1.1.73"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the faeC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.73" evidence="11"/>
    <dbReference type="EMBL" id="MU854347">
        <property type="protein sequence ID" value="KAK4042052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6STJ4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030600">
        <property type="term" value="F:feruloyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043595">
        <property type="entry name" value="FaeB/C/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38050:SF1">
        <property type="entry name" value="FERULOYL ESTERASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <keyword evidence="4 11" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042670661" description="Feruloyl esterase C" evidence="11">
        <location>
            <begin position="21"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="13">
        <location>
            <begin position="291"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK4042052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="327" mass="34015" checksum="1CB11B10DC3A09DF" modified="2024-10-02" version="1">MISFPTLALALLGAVQTVESASAGCGKSPASSGTKSMTVNGKQRQYILQLPGNYDSNKAHRVVFGYHWRDGSMNDVAGGGFYGLLSLAGGSTIFVAPNGLNAGWANNGGEDITFTDQIVALLKNDLCVDEGQFFATGWSYGGSMSHSVACSRPNVFKAVSVIAGAQLSGCSGGNTPVAYLGIHGTADNVLGIGLGRQLRDKWMQTNGCVSKNAPEPSAGQQSDIKTTYSCSRAPVTWIAHGGGHVPDPSGTNGVKFAPGETWTFFNAAVSSDPSTSTPTTNPGTEPTNPTTCSPKWGQCGGREWTGLTCCQSGSTCRATNEWYSQCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SUJ6</accession>
    <name>A0AAN6SUJ6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CENP-C homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_44279</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CENP-C/MIF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854336">
        <property type="protein sequence ID" value="KAK4042785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SUJ6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019237">
        <property type="term" value="F:centromeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051455">
        <property type="term" value="P:spindle attachment to meiosis I kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06993">
        <property type="entry name" value="cupin_CENP-C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000033">
        <property type="entry name" value="Centromere protein C 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028386">
        <property type="entry name" value="CENP-C/Mif2/cnp3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025974">
        <property type="entry name" value="Mif2/CENP-C_cupin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028929">
        <property type="entry name" value="Mif2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16684">
        <property type="entry name" value="CENTROMERE PROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16684:SF11">
        <property type="entry name" value="CENTROMERE PROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11699">
        <property type="entry name" value="CENP-C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15624">
        <property type="entry name" value="Mif2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mif2 N-terminal" evidence="9">
        <location>
            <begin position="19"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Mif2/CENP-C cupin" evidence="8">
        <location>
            <begin position="594"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="30"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="490"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="679"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="131"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="186"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="221"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="262"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="367"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="490"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="506"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="517"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="691"/>
            <end position="718"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00057947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00075033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF11699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF15624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4042785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="718" mass="78430" checksum="94AAA6EBE189F014" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SUK1</accession>
    <name>A0AAN6SUK1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_33191</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854337">
        <property type="protein sequence ID" value="KAK4042666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SUK1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37332:SF1">
        <property type="entry name" value="ELMO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37332">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <end position="94"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="349"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4042666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="487" mass="51204" checksum="2CC87B7FA43E772A" modified="2024-10-02" version="1">MQRSAATPTQSAAPFFSSLFGGGGSGSGGTNNTANTKDHDPPPSPTSKPARPTSSSEDVAGGSPRQPRPLVHDRKPSSSGRKSSFGFLSSSSPGKKTRRRADSAASNPAAQADGGGVPVPSLAHRPSATQLSSQDTVPSLPDPSPKTTTDGFSKMLSRGAVTPISGYPVGMAGSGTMLGGGGGGMAMAQQSELGVVHQHIQETANKRISTLDYLRKASHEGRIYWFNTLLFDKPDLQRMPYFDARKLGRRATNYLLLGISLPAVIDLNSNTPTEFLRSLNTLLTEFDAFQQIHTETGIAATSLTRTRIPQMFRRAAAPVSKGRRSSSAAGRDGDIAIIGYSLEQVDSNNNNTTSAPATIPPSTSSGAGVGDATPAGGVMAFGASEVDLLPGEEYTYLLTPTLPFDPDFFETFATLCDALIDTYTRLLGLVPTARECSGPVAELFTKVDSKIRKLFIQGVMREFEESGRAGVKAELASVGKVVLSGLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SUK2</accession>
    <name>A0AAN6SUK2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF1275 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_32196</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854325">
        <property type="protein sequence ID" value="KAK4043669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SUK2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010699">
        <property type="entry name" value="DUF1275"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37488">
        <property type="entry name" value="DUF1275 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37488:SF2">
        <property type="entry name" value="DUF1275 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06912">
        <property type="entry name" value="DUF1275"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="185"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="242"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4043669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="301" mass="32023" checksum="306B772C5451D3DD" modified="2024-10-02" version="1">MPPQEKESTPSSPSCGRSHETHDHSLSKTYTQPPSTRSKAWTHLNENVRASGLAELELLILTFCIGLQDAVSFPDFHCFASNQTGNTVFLMLAIVLPEADGDMFHTANIGIALGFFLAAAWLTGQLGHVVGARRRCWLVLCNLLQTGLVFAAAALQYAHQLPTATSGSGSESGSSLALDGGRSPSTLWAIGLLAFAAGSQVVQARSLRMTEITTAMATAAWVDLMIDPDLLVWRNRGRNRRVGFLGALVLGSLAGAFIFRRVGSPAALVVSGAGKLLVTGMYLFNPADRPPKVEESAEDSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SUN0</accession>
    <name>A0AAN6SUN0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sec1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_13741</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854337">
        <property type="protein sequence ID" value="KAK4042698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SUN0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005715">
        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="612"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="624"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4042698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="720" mass="78464" checksum="DCF7A0514939A92D" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SUT9</accession>
    <name>A0AAN6SUT9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">lytic cellulose monooxygenase (C4-dehydrogenating)</fullName>
            <ecNumber evidence="15">1.14.99.56</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">C8A01DRAFT_32037</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the polysaccharide monooxygenase AA9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="15"/>
    <dbReference type="EMBL" id="MU854323">
        <property type="protein sequence ID" value="KAK4043939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SUT9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF11">
        <property type="entry name" value="GLYCOSYLHYDROLASE FAMILY 61-7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043008505" description="lytic cellulose monooxygenase (C4-dehydrogenating)" evidence="16">
        <location>
            <begin position="20"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="17">
        <location>
            <begin position="20"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAK4043939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="223" mass="24077" checksum="955E0A141021CD32" modified="2024-10-02" version="1">MKLTTILAALTLSAADVSGHYIFQQFSLGSKKFGVYEHIRKNTNYNSPVTSLSSNDLRCNVGGNSGASTTVLSVQAGESFTFFSDVAVYHQGPISLYMSKAPGSVNDYDGSGDWFKIYDWGPTFNGGQSSWPMRNSYQYTIPKCIKNGEYLLRIQQLGIHNPGSPPQFYISCAQVNVTGGGNASPSPTVKIPGAFKASDPGYVANIYNNFNSYTVPGPAVFNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SUY8</accession>
    <name>A0AAN6SUY8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Vacuolar protein sorting-associated protein 68</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_32847</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0220 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854332">
        <property type="protein sequence ID" value="KAK4043056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SUY8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007919">
        <property type="entry name" value="UPF0220"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13180">
        <property type="entry name" value="SMALL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05255">
        <property type="entry name" value="UPF0220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4043056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="171" mass="18653" checksum="9347638AC03730D1" modified="2024-10-02" version="1">MSEDRLWKFRRPEWLNSVWARNAGVYAAGGLFSLAFYTLLDAAVWSKSPLNGSYVHVTFVDWLPFIFSSLGMLIINSVEKARLSADSFSYSGSGVAWKARVVLFLGFAALAGGMAGGVTVFVLKFVVKEVGFPAMAMGVENVVANALVGLSSVVLWVSQNMEDEYSYNLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SV70</accession>
    <name>A0AAN6SV70_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_31631</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854320">
        <property type="protein sequence ID" value="KAK4044314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SV70"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.30">
        <property type="entry name" value="Dynein light chain 2a, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="174"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="210"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4044314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="316" mass="32018" checksum="74A162ED56FF7980" modified="2024-10-02" version="1">MSRIMQMPPPPPLLLTKRVTSFLRANLSSHIHSAMLTTPAGSLLAHASSLPASALRRQAAVAASLWALQGPAPTSHDPATASIPPGSTVRTRRSGKHAPPTVTVQLDSGAVFVIRRLRCGMLFICMGGAEAAAAAAAASGRLTPTPPAPHMTRLSRSPAPTAPTTEAQSRDQPPDTTTTTTNPSTTPRPSTPPPPSAPPQPLIPTPPNPATMGNTNATTAPPTGNPPSSTTTPNSPSQASILSTHTTGAASTTSTATFSGGSSVSLMRRQVEELARWLDERLGGLCVPEEGIGIFGASGGMGAAGNGVAGGGLEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SV95</accession>
    <name>A0AAN6SV95_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Formate/nitrite transporter-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_31429</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the FNT transporter (TC 1.A.16) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854319">
        <property type="protein sequence ID" value="KAK4044374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SV95"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015513">
        <property type="term" value="F:high-affinity secondary active nitrite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015707">
        <property type="term" value="P:nitrite transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1080.10:FF:000011">
        <property type="entry name" value="Formate family transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000292">
        <property type="entry name" value="For/NO2_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024002">
        <property type="entry name" value="For/NO2_transpt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30520">
        <property type="entry name" value="FORMATE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30520:SF6">
        <property type="entry name" value="FORMATE_NITRATE FAMILY TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01226">
        <property type="entry name" value="Form_Nir_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01006">
        <property type="entry name" value="FORMATE_NITRITE_TP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="124"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="208"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="246"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="307"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4044374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="330" mass="35935" checksum="3EB7B880D53CB9FB" modified="2024-10-02" version="1">MATQTVHVANLASYTPTETIELVSRMGASRGRMRPDKIFFSAISSGCLLCFASAASLIATASPWLQENAPGIVRIISGLVFPSGIVMIISRGDSQAIRGRTITGTNMITAVAAYHRRLPIQKMLLHWFLCFWGNLAGSLFVMAVILGYGGVFDHSPYRDQAISNAKQKQVDLKFRQIFLRALGCNWLVCLACYLGLQAKGLTPKVVGMWWPVFVFVTLVLEHVVANMFFIPIALFLGTPDLTVGLYIWKGIIPTALGNVMGGAGFCGAFYYWLYIFDEPDICVDGAYYQRLDEDTLFGSRSPTVAVEADGGKDGSSSGDLAGNNNNTKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SWN2</accession>
    <name>A0AAN6SWN2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">5'-AMP-activated protein kinase beta subunit, interation domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_42441</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 5'-AMP-activated protein kinase beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854316">
        <property type="protein sequence ID" value="KAK4044826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SWN2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031588">
        <property type="term" value="C:nucleotide-activated protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02859">
        <property type="entry name" value="E_set_AMPKbeta_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000562">
        <property type="entry name" value="Snf1 kinase complex beta-subunit Gal83"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.250.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032640">
        <property type="entry name" value="AMPK1_CBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006828">
        <property type="entry name" value="ASC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037256">
        <property type="entry name" value="ASC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050827">
        <property type="entry name" value="CRP1_MDG1_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10343">
        <property type="entry name" value="5'-AMP-ACTIVATED PROTEIN KINASE , BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10343:SF84">
        <property type="entry name" value="5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16561">
        <property type="entry name" value="AMPK1_CBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04739">
        <property type="entry name" value="AMPKBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01010">
        <property type="entry name" value="AMPKBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160219">
        <property type="entry name" value="AMPKBI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Association with the SNF1 complex (ASC)" evidence="5">
        <location>
            <begin position="360"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="318"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="134"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="203"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="336"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4044826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="470" mass="50124" checksum="F081E1144E8D895B" modified="2024-10-02" version="1">MGNSPSNTAKSASQSSSSPTHSQHDRPVRRDNRNPIPVQGLRVAAPPEPSLTQAQGTAVQPPSSASNGAASRPKPLHPRPLGSGAVASGSSTASSSTTATSSTSSAKPVEVKQGKPSPCHAPAKPVAVPNTHNSPSSPRSEYSYEAAAMPHSSVQDVSYLTRPPRLPLPIEEEVHTPGSPILAPTDVGEPVDDVQGLDKTSLAHPTSNLSDTSVLEEDDADAEELLVDKTRPTVPTRLEWRHGGDKVYVTGTIFQWNRKTRLHPVEGQPGVFTTTINILPGTHHIRFLVDGQMQTTPDYPTTVDFGNNLVNYIEVNPDDLQPAPAETDGASEGKTAQQQAQAEAAPAEEDGAPPVPRDREVPPASLFEHKIPKYLVDLDQPEDSPQYHHAVLATEKLPNPPGLPGFLSKPILNAATPRKDDNSVLTQPNHTVLNHLATSSIKNNVLAVSATTRYKSKYVTTIMYKPTAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P4K8</accession>
    <name>A0AAN6P4K8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_51440</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854785">
        <property type="protein sequence ID" value="KAK4031495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P4K8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38794">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38794:SF1">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="169"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="213"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="241"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="3">
        <location>
            <begin position="68"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4031495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="358" mass="39850" checksum="87D8B2B2B00FA041" modified="2024-10-02" version="1">MDQPVTRQDHDGSGASPAGNFATSSNQNPILQVLTWLLLTLTTLMLGFRLLTQFFIKSNGVSRLEELLILAAAMIGRPLTSLTDNQLRMGLKAAYAGELLFLFSLGFARLSACAFLHRMSPNLGHKRATQAMAGLILLWTVSAVFSAAFQCGARLPWGADTSCFDERAFLSYVGISSIVTDAILISAPIVVIIPLRLPLKTRVAAMTVFASRIRVRTIVTTALQLAFLPRLFDGDFTFRGFPYFVCTQFVQFTSISAACLTYFWPLLRSLQSGLMDAHNTNFTSQYSLSALSQGKSKMNKSSTEGTTTSRDRNRREYIEITTDYRVNVGGDIMEGRERGLDLNRDRYERVWHQGHTRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P4Y0</accession>
    <name>A0AAN6P4Y0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">NodB homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_41808</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854710">
        <property type="protein sequence ID" value="KAK4031749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P4Y0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10917">
        <property type="entry name" value="CE4_NodB_like_6s_7s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471">
        <property type="entry name" value="CHITIN DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471:SF6">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0170">Cobalt</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043034519" description="NodB homology domain-containing protein" evidence="7">
        <location>
            <begin position="23"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="8">
        <location>
            <begin position="573"/>
            <end position="766"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4031749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="780" mass="83978" checksum="A30B43F2DB0017DE" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P5V8</accession>
    <name>A0AAN6P5V8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alpha-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">C8A01DRAFT_20577</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing (1-&gt;4)-linked alpha-D-glucose residues with release of alpha-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.20"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.20" evidence="3"/>
    <dbReference type="EMBL" id="MU854621">
        <property type="protein sequence ID" value="KAK4032344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P5V8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004558">
        <property type="term" value="F:alpha-1,4-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06602">
        <property type="entry name" value="GH31_MGAM_SI_GAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030458">
        <property type="entry name" value="Glyco_hydro_31_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF95">
        <property type="entry name" value="ALPHA_BETA-GLUCOSIDASE AGDC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00129">
        <property type="entry name" value="GLYCOSYL_HYDROL_F31_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042948754" description="alpha-glucosidase" evidence="7">
        <location>
            <begin position="18"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 N-terminal" evidence="9">
        <location>
            <begin position="95"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="8">
        <location>
            <begin position="265"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="10">
        <location>
            <begin position="663"/>
            <end position="749"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK4032344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="851" mass="94738" checksum="7D63200541BC2B78" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P6M6</accession>
    <name>A0AAN6P6M6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_50630</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854591">
        <property type="protein sequence ID" value="KAK4032605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P6M6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20826">
        <property type="entry name" value="PHD_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="698"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="61"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="112"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="291"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="352"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="535"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="756"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="291"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="309"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="358"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="478"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="549"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="561"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="600"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="646"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="668"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="762"/>
            <end position="777"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4032605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="785" mass="83462" checksum="68051819614EFE18" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P6Y3</accession>
    <name>A0AAN6P6Y3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_41603</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854671">
        <property type="protein sequence ID" value="KAK4031957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P6Y3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042972718" evidence="1">
        <location>
            <begin position="23"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4031957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="140" mass="15224" checksum="6037EA8EE58451FB" modified="2024-10-02" version="1">MQFTTLLAATLTLISAPTAVLGWAKDAKGVWVANNKVYARVGNFNNVHESCTRMNSQEVYTDKRMCAYWVNSNGEKRYGHCVNRSNKVECVPGCATYEVCNISMEDGSCEWGPAACLEKMGCGGRAGEADCLNFGCDAIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P765</accession>
    <name>A0AAN6P765_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Aspartic peptidase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">C8A01DRAFT_51343</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854740">
        <property type="protein sequence ID" value="KAK4031643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P765"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05474">
        <property type="entry name" value="SAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033876">
        <property type="entry name" value="SAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF65">
        <property type="entry name" value="ASPARTIC-TYPE ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042919871" evidence="10">
        <location>
            <begin position="18"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="499"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="11">
        <location>
            <begin position="59"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="458"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="465"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK4031643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="519" mass="54398" checksum="BFB19E8B79E51338" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P7S5</accession>
    <name>A0AAN6P7S5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_40226</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854538">
        <property type="protein sequence ID" value="KAK4033316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P7S5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03753">
        <property type="entry name" value="proteasome_alpha_type_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000015">
        <property type="entry name" value="Proteasome subunit alpha type-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033812">
        <property type="entry name" value="Proteasome_alpha_type_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003075">
        <property type="entry name" value="PRK03996.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 5 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="7">
        <location>
            <begin position="8"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4033316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="245" mass="26947" checksum="2A91D11CC9D61340" modified="2024-10-02" version="1">MFMARSEYDRGINTFSPEGRLFQVEYSLEAIKLGSTAIGVATSQGVILGVEKRVTSTLLETSSVEKIVEIDRHIGCAMSGLQADARSMVEHARVECQSHAFNYNEKLRVESCTQAICDLALRFGESADGEESIMSRPFGVALLIAGYDEDGPSLYHAEPSGTFYRYDAKAIGSGSEGAQAELQNEYHKSLTIEDAETLVLKTLKQVMEEKLDAKNVQLASVTKDRGFRIYTDEEMAAVVERLPAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P7X2</accession>
    <name>A0AAN6P7X2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_19723</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854538">
        <property type="protein sequence ID" value="KAK4033310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P7X2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018828">
        <property type="entry name" value="RRG7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28133">
        <property type="entry name" value="REQUIRED FOR RESPIRATORY GROWTH PROTEIN 7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28133:SF1">
        <property type="entry name" value="REQUIRED FOR RESPIRATORY GROWTH PROTEIN 7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10356">
        <property type="entry name" value="RRG7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4033310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="290" mass="30967" checksum="6CED73320F7AAE3C" modified="2024-10-02" version="1">MRASLLRRLLPPRLPQVPLQRSFSSAVPAQPNPTPLSSEAQQSEHQPQQPPPPPPPENDTSPSPLPTATATTTPPTTSPPLIYPSAPSPHHTTLPTFLAHAARTNLDPSSTVYVGTHFEYTTLHALARYNLHLQRVGGVSDYGIDLLGTWTLPSLNTPLKVLAQCKAVQRPGPHLVRELEGAFVGAPAGWRGTSGVVGILVAERSATKGIREALARSRWPMGFVACSREGVVEQFLWNRRAEEEGLEGVGVGMRYAGGRGGDGGDGGGKELVLTWRGRNLPFVEGEGAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P844</accession>
    <name>A0AAN6P844_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid permease-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_42057</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854786">
        <property type="protein sequence ID" value="KAK4031491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P844"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF498">
        <property type="entry name" value="HIGH-AFFINITY METHIONINE PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4031491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="147" mass="15478" checksum="F3C3C2C9B245CEC8" modified="2024-10-02" version="1">MVKFFTTQASHAKRPDNDSEAAGSDGNDGQVGHLQEARDAKRQIGVVSATFLVVNRIIGTGIFATPGAILALSGSVGLSLFIWVAGTLIAAAGTAVYMEFGTAIQRNGGEKNYLEYVFRKPKFLATGLYTGYVVLLGWASGNSVVFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P851</accession>
    <name>A0AAN6P851_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_21506</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854934">
        <property type="protein sequence ID" value="KAK4031247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P851"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4031247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="97" mass="10597" checksum="1B8FF4F4D40D51F9" modified="2024-10-02" version="1" fragment="single">PTSPSLPIPHDINVVATPGNDTSYAPMAICCAPSTVQIVDRCYLWCDIPKRVLNGINGHPGHWEVEAGMGMYGSEMDNFYILFRSSLMCAHALSKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P8Y3</accession>
    <name>A0AAN6P8Y3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_40614</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854563">
        <property type="protein sequence ID" value="KAK4032930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P8Y3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="127"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4032930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="395" mass="42493" checksum="7C3BD4EFF216ECC9" modified="2024-10-02" version="1">MSSPRTPHHSPHPSLDYSAASYSPQDRRQSKASSFNDSSMDLGISASGGGGGGGGGGLGNLADELAGAFSDGEDDYDGYEERDYDEEAADEQGSEGRAPGIHLEDTTTGEDARKDDGVRDSGVDVESPSGSGKSHNSKGSLGLPAPNGRGHRRKGSEYDGSEYGSESDLESPGMPPKLVEKIDEVESLARRGTENNGSPTDGAFKRVTDGLRDLGSQANVEGGATRLITAHSALTTHLTHQTRHLHNLTFPLLSPLAAPPTEETLESLLPMLLTLTDLMPRPTTPALQSLSSLHTLTTDLVQTLNYLSDTLHMSRQTTTTATRRLRAAREMVAELRREEELREEGERWLAKGDWGERLARRECAHVCGEVVGGFEAVCESWRERLVSKLEESSQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P913</accession>
    <name>A0AAN6P913_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_20356</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854594">
        <property type="protein sequence ID" value="KAK4032573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P913"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053175">
        <property type="entry name" value="DHMBA_Reg_Transcription_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="10"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4032573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="505" mass="54598" checksum="147326CCC6EDC0CB" modified="2024-10-02" version="1">MPYCGRPSTACHACRVKRGKCDRKKPGCGQCARKRTPCPGYPDPLAVVFRDQTLATTRKVQRKSDLPPDMAPYSMPVALALPKSLPVATEDVATTFFLTSYAPTSPTGYLSDLADGLLNDGLSSSAVLAPALATLSRELVQPSLMALARKHYSVAIQQTNTALASRELAVKDETLASVLLLALFEASAFQGRRSPTGWTMHVDGAAQLLKMRGPSQFDSPLGRSMFLDIVSDIFISCAQRRVAVPRALTELLAQLGDVVGHDDLGVGMARVTADMADLVALVALLAAGGDRLASVAVQVVRRGRQLDADLDRMLERYREIRPYTVIDPASAPESAYNGLAHHYSSHKLCWQWNNLRMMRLFANRSIVRVAAAAATGSPLQDSPEAVDVLQQPRLLEMAASTAERMAADILATVAYCNSLPAASNARLATARWLIWPLSVVATSTVAPLSARIYARDTLYALGRDSGISQAAEAGKMVDETNNQLEDWCVIETNICILRMTTRSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P928</accession>
    <name>A0AAN6P928_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_49564</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854502">
        <property type="protein sequence ID" value="KAK4033940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P928"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050114">
        <property type="entry name" value="UPF0173_UPF0282_UlaG_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43546:SF3">
        <property type="entry name" value="UPF0173 METAL-DEPENDENT HYDROLASE MJ1163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43546">
        <property type="entry name" value="UPF0173 METAL-DEPENDENT HYDROLASE MJ1163-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13483">
        <property type="entry name" value="Lactamase_B_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="121"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4033940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="341" mass="36858" checksum="392D805DBCBE88D1" modified="2024-10-02" version="1">MSGNDTSDAGATTLEWFGATTFRLKTKGLTIFLDAWLERPSSIPTYIRIEDVHEADYILISHAHFDHLPGADKLAKRTGAIIIGNGEAINVMRGAGIPETQLIAVAGGERIPLFTAEQRKAAAAAENQQPRGPLDAGGPPPGPPQPSPDQAVVTLHAWPSLHCLMPPASGDGGLSSHPDSIDTATRYTGDVGGFNCTLDITRALTYKLGSLVEMPQLPPQLPDSMRVFVEYMRDRDANRYSNFDGGQITYNFLIGPGKTLLWSGHLGGYEGVLAHLEPKPDFALLAIAGRANLDGRLRGRGGLVAPLKPWYIDSRAATELVHKETKSKVVELEHAKVFQLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P9E4</accession>
    <name>A0AAN6P9E4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_40283</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854542">
        <property type="protein sequence ID" value="KAK4033247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P9E4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043032668" evidence="2">
        <location>
            <begin position="24"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4033247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="118" mass="9895" checksum="28F3E395B99A6DB4" modified="2024-10-02" version="1" fragment="single">MKSNLGLAISGFLGLALHAGAQGVNPFGNNAGAIPGDSTGGQNPFTGGSGSGSGSANSGAGSGSANSGAGSGSANSGAGSGSANSGAGSGSANSGAGSGSANSGAGSGSANSGAGSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PA98</accession>
    <name>A0AAN6PA98_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DNA-directed RNA polymerase subunit beta</fullName>
            <ecNumber evidence="14">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">C8A01DRAFT_41249</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25 26">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="14"/>
    <dbReference type="EMBL" id="MU854623">
        <property type="protein sequence ID" value="KAK4032327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PA98"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.150:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000005">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1110.10:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1800.10:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="entry name" value="DNA-directed RNA polymerase, subunit 2, domain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1800.10">
        <property type="entry name" value="RNA polymerase alpha subunit dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="entry name" value="RNA polymerase Rpb2, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007646">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007647">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04566">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04567">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 14" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 14" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RNA polymerase beta subunit protrusion" evidence="19">
        <location>
            <begin position="58"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="18">
        <location>
            <begin position="264"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="20">
        <location>
            <begin position="529"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="21">
        <location>
            <begin position="628"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="22">
        <location>
            <begin position="729"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase subunit 2 hybrid-binding" evidence="16">
        <location>
            <begin position="806"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="17">
        <location>
            <begin position="1180"/>
            <end position="1272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="767"/>
            <end position="787"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF04566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF04567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KAK4032327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1280" mass="143779" checksum="0A6B2363D7216EB1" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PAE0</accession>
    <name>A0AAN6PAE0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_38858</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854469">
        <property type="protein sequence ID" value="KAK4034699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PAE0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF59">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G10370)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="389"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="433"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="473"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="500"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="537"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="570"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="156"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="36"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="52"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="67"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4034699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="613" mass="65815" checksum="F59743F7EB516FE8" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PAK9</accession>
    <name>A0AAN6PAK9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Acyl-CoA dehydrogenase/oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_39668</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854506">
        <property type="protein sequence ID" value="KAK4033860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PAK9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050741">
        <property type="entry name" value="Acyl-CoA_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083:SF28">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="9">
        <location>
            <begin position="7"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4033860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="516" mass="57344" checksum="5E7776E8AB04AB3A" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PAS4</accession>
    <name>A0AAN6PAS4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_49543</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854501">
        <property type="protein sequence ID" value="KAK4033965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PAS4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053025">
        <property type="entry name" value="Mito_ATP_Synthase-Asso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44873">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 30, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44873:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 30, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="48"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4033965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="326" mass="34386" checksum="1725CF250BAC5221" modified="2024-10-02" version="1">MPLRYTPTGAALTAQLQLPARTAAWSCHRFFHASPRALRLEASTGSNNHYETLNVHPSASPAEIKKSFYLLSKRHHPDHNPSDPHAPTRFMRISEAYAVLGHADKRARYDRDNIRQNPHYHHHSQKGSYHSTGPAGGRPASGLSRRRGTYQGPPPSFYRSGGWGAHGAKRRAAHEESTGTGTGTGSEAGFGTNSSHSPSGPGPGTAGGSGVGAGAPPPPPPPPPPPGGGGFGTAGGMGPGQDPYGHQDDVPHFDRAAHERAQRRGDERRAHRLARERGVNIDQPDSATTMSFFGVVAILAIVVSGPFLLSSAGSSSNSKGREGKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PAW8</accession>
    <name>A0AAN6PAW8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Na+ dependent nucleoside transporter C-terminus-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">C8A01DRAFT_48783</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854460">
        <property type="protein sequence ID" value="KAK4034953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PAW8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005337">
        <property type="term" value="F:nucleoside transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008276">
        <property type="entry name" value="C_nuclsd_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011657">
        <property type="entry name" value="CNT_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002668">
        <property type="entry name" value="CNT_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011642">
        <property type="entry name" value="Gate_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10590">
        <property type="entry name" value="SODIUM/NUCLEOSIDE COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10590:SF4">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 28 MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07670">
        <property type="entry name" value="Gate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07662">
        <property type="entry name" value="Nucleos_tra2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01773">
        <property type="entry name" value="Nucleos_tra2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="204"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="287"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="322"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="364"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="452"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="489"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="551"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="588"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="domain" description="Concentrative nucleoside transporter N-terminal" evidence="9">
        <location>
            <begin position="208"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoside transporter/FeoB GTPase Gate" evidence="11">
        <location>
            <begin position="290"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="Concentrative nucleoside transporter C-terminal" evidence="10">
        <location>
            <begin position="393"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK4034953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="615" mass="67590" checksum="64B694BEFB55EBEC" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PB79</accession>
    <name>A0AAN6PB79_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_18067</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854451">
        <property type="protein sequence ID" value="KAK4035214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PB79"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4035214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="94" mass="9613" checksum="696F892D3EEAADD4" modified="2024-10-02" version="1">MPHKPLRQIAAEKARGNKPANPSQLGDPIDLKAETSDEPDPVESPGDGIGADLNLPRASLEGDPNKKGEERGVVIGLGSGAGPVGGVRKKGSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PBL5</accession>
    <name>A0AAN6PBL5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_40557</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854559">
        <property type="protein sequence ID" value="KAK4033002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PBL5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4033002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="397" mass="45135" checksum="420DB4B4F5B77905" modified="2024-10-02" version="1">MPALQTFVWPEEWRLMSGTVAALHESCSRLKAIHYYGHSDRVELFRLRTDSSPATLYNFSGFANLHQLTLSQLRGDLAWWKGNVVHILRHSPGLRSLELSISAKSIRSRRNYDTNFFDQLCGGYAAVGGLPLCLQSLRCGQGVFPMSHASLAKLTDVSHLEEVHIFNHQEYWGQDDVQLYPSEQSRSGIVFNAFWPQHCPNLRRFSVSIYQLDVHEFLCAWAVDPSFSRRLAFCVDDLRHLGYGDPSLLFRPNSGHPGRHPGLPIKLRMLGLDLDRDTIFRSVPDLDEEYWREEVLGDIVASNTESLEGLMICTPMHQDDDSYSIGLNTELTRFYDLDVLQEVIGRFHHLKQLSVNGHRPLPDSDWGPPTPEAILDAAKKLAGAAPGLMYINIYERF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PCD1</accession>
    <name>A0AAN6PCD1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyoxalase/fosfomycin resistance/dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_49375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854491">
        <property type="protein sequence ID" value="KAK4034178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PCD1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36503:SF2">
        <property type="entry name" value="BLR2408 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36503">
        <property type="entry name" value="BLR2520 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyoxalase/fosfomycin resistance/dioxygenase" evidence="1">
        <location>
            <begin position="12"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4034178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="147" mass="16001" checksum="A67F414663664EAE" modified="2024-10-02" version="1">MSTTPRPTFFLNLPTTSLPTATAFYTALSFTPVQAWSDAQTAAFLLPAPNQAVALMVHTHDRFAQFTRPGTAIADARASSQALFSIMCKDKEGVDGWLERVERAGGKRDPYVMEGYGEGMGMYVWSWEDLDGHVWEGVCMLGMGGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PDR6</accession>
    <name>A0AAN6PDR6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_16939</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854412">
        <property type="protein sequence ID" value="KAK4039026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PDR6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="60"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4039026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="306" mass="34274" checksum="84E49924FE49AEF3" modified="2024-10-02" version="1">MAAGKLPKITDEKELQIWTCWNPETATELVKWHHFTPDDEAYIGKSHQGRFEITLDEFAAGLRRISDDAIFPEVPAGTQITTAPNNLDGAAVYIKRSGLKRYGMLKGDDCGAKEQMLGEALVMEKISKTPHPYIVRYHGCRVHRGRITGIVLEKLGDTLNNYAYCEPDEDEPRSRFEQIDKEAFLAGVESAIKFLHSLGLAHNDISPYNILVREAGDGSCMPVLIDFDSCGPFGGQLLSLGTAGFFDAEDKECGISHKKHDEFALKRLSEWWDKEHSSETHPFLGAIMEEAKKKQEDLEGSEDEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PDV4</accession>
    <name>A0AAN6PDV4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_36989</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854411">
        <property type="protein sequence ID" value="KAK4039086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PDV4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="152"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4039086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="510" mass="55616" checksum="EF1DC03C7C4D0D0F" modified="2024-10-02" version="1">MTHANKAISVPLDDWDTDDPSDDGATELQGTDLREGMPRKYKAAAKTQANKAVSSSATGKANTDDARGDETKKRVQFEGAEAEKAKATNKNTSGTNTREPSGAITSDMMQFFHVCKALLVGILSDAMQFSTALLLGLVWLLRLSWPACRKIIILYVFFLGITYSVSFALNRGREALSAAVCPIPIVGSRLALCQPLPSPTPPGSDILSKISAPQEGLAAVMGRLGHDHSLSRQLVNHSFAVHDLKIRVEVSKLARKDALANDLGILMDSTEKTAEGLAELTAKVGGTVDTVTAMDDHTVRRLEELAQDAARRQRNRRGLAGRVIAAVHPLAGLAAYDPGPAEVKKLIRSTTDYLAERVELLLADAAALSFELRYIRELLGSIQKLTKEETGNLPAHGPLEALWSLLGRPSESVWMRKPHKKLLTDITRLYEKATAIVQDVTGTLMQVRAELKQFKTERINQIVLLEEHPFDAIAAKIRSSMQRLEASKKNLDGRGATRFAEATLKQKESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PDX4</accession>
    <name>A0AAN6PDX4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">IBR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_16878</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854410">
        <property type="protein sequence ID" value="KAK4039116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PDX4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="IBR" evidence="6">
        <location>
            <begin position="451"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="530"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="653"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="712"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="837"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="889"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="947"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="137"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="191"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="216"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="264"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="311"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="532"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="557"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="654"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="747"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="774"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="858"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="890"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1001"/>
            <end position="1010"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4039116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1051" mass="116135" checksum="D6DB0189B53BD572" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PE52</accession>
    <name>A0AAN6PE52_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_16728</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854405">
        <property type="protein sequence ID" value="KAK4039258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PE52"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106:SF18">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE PIG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE PIG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="4">
        <location>
            <begin position="22"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="124"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="125"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4039258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="375" mass="39802" checksum="D6A89063659CCAC3" modified="2024-10-02" version="1">MSGTDPTTTPQTMKAILISSFGPPENLVIRDDIPLPVPTPGTARIRIRAFGINHAEMHMRRGEWAESVPISGIECVGTIDDCPGGEFAAGTPVASVMGGLGRTIPGSYAQFTVARVENIVPLTTPPTATTTTSTSTSTSTATDSNVTVSEDLGSGEPPLPLPWAQLAALPESYCTAWTCLFRNLALQRGERLLIRGATSAFGRAAVNLAVEAGAVVTGTTRSEAKFAELRALGAAEAVLEGPGLPGRLLNGGNTKKFDKVLELVGNSTVVESLTLVRRDGRVCLAGWLGGLDPIREFNPLLQMASGVHFSFFGSFVFGTPEFPLSDVPLGKIVRAVADGKFEAKPFKVFRFDEIQEAHRYMDDGRARGKMVVVVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PED4</accession>
    <name>A0AAN6PED4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha-dextranase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_16609</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854401">
        <property type="protein sequence ID" value="KAK4039407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PED4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.350.10">
        <property type="entry name" value="Dextranase, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041402">
        <property type="entry name" value="B_solenoid_dext"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035953">
        <property type="entry name" value="Dextranase_N-ter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005192">
        <property type="entry name" value="Glyco_hydro_49_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023226">
        <property type="entry name" value="Glyco_hydro_49_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041274">
        <property type="entry name" value="IPU_b_solenoid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18841">
        <property type="entry name" value="B_solenoid_dext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03718">
        <property type="entry name" value="Glyco_hydro_49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17433">
        <property type="entry name" value="Glyco_hydro_49N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18783">
        <property type="entry name" value="IPU_b_solenoid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101596">
        <property type="entry name" value="Dextranase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 49 N-terminal" evidence="2">
        <location>
            <begin position="5"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 49 C-terminal" evidence="1">
        <location>
            <begin position="473"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4039407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="578" mass="63585" checksum="41D8A509D22569E6" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PEF6</accession>
    <name>A0AAN6PEF6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_18418</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854463">
        <property type="protein sequence ID" value="KAK4034866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PEF6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042937788" evidence="1">
        <location>
            <begin position="19"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4034866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="99" mass="10957" checksum="800A76E725FCDC18" modified="2024-10-02" version="1">MKSFVLAMIVSTMGGVMADRLLACGHHLVNSERHQWSQTDIARAACGREDTCDGKEWNTLFEVLPMSSGPASWVEIQTTGVFCHLGCWGDIDRFNGQCH</sequence>
</entry>
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    <name>A0AAN6PEJ8_9PEZI</name>
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        <submittedName>
            <fullName evidence="9">Aspartic peptidase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_18028</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
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        <lineage>
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        </lineage>
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    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Ament-Velasquez S.L."/>
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                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
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                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854449">
        <property type="protein sequence ID" value="KAK4035273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
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        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
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        <property type="entry name" value="Pepsin-like_dom"/>
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    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
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    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF75">
        <property type="entry name" value="ENDOPEPTIDASE (CTSD), PUTATIVE (AFU_ORTHOLOGUE AFUA_4G07040)-RELATED"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="535" mass="56017" checksum="C44DD963E6346757" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2025-10-08" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PEP0</accession>
    <name>A0AAN6PEP0_9PEZI</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_47747</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
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        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
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                <person name="Brannstrom I.O."/>
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                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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            <end position="1644"/>
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    <feature type="compositionally biased region" description="Pro residues" evidence="2">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1401"/>
            <end position="1441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1467"/>
            <end position="1479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1488"/>
            <end position="1501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1538"/>
            <end position="1555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1562"/>
            <end position="1574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4038668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1696" mass="177895" checksum="5BC903CE2A242F79" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PF55</accession>
    <name>A0AAN6PF55_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11 12">Endo-1,4-beta-xylanase</fullName>
            <ecNumber evidence="4 11 12">3.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">C8A01DRAFT_16984</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11 12">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
            <dbReference type="EC" id="3.2.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11 12">Glycan degradation; xylan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11 12">Belongs to the glycosyl hydrolase 11 (cellulase G) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.8" evidence="4 11 12"/>
    <dbReference type="EMBL" id="MU854414">
        <property type="protein sequence ID" value="KAK4038953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PF55"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013319">
        <property type="entry name" value="GH11/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018208">
        <property type="entry name" value="GH11_AS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033123">
        <property type="entry name" value="GH11_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001137">
        <property type="entry name" value="Glyco_hydro_11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46828">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46828:SF2">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00457">
        <property type="entry name" value="Glyco_hydro_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00911">
        <property type="entry name" value="GLHYDRLASE11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00776">
        <property type="entry name" value="GH11_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51761">
        <property type="entry name" value="GH11_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11 12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9 11 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 11 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 11 12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11 12" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042987963" description="Endo-1,4-beta-xylanase" evidence="13">
        <location>
            <begin position="19"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="GH11" evidence="14">
        <location>
            <begin position="25"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK4038953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="220" mass="23437" checksum="5763A9B0A9D07813" modified="2024-10-02" version="1">MVQFSLLAAGLLAPAVLAAPTPEPVAANSLEARFDGNGFNSWSEGGSNIKCVNGPGGSFTANWNSKGGFVCGKGWNGQGARTIKYSGTYNATGPGYLAIYGWTRNPLIEYYIVDSHADLAPNEPWTSKGEFTSDEGTYEIFTSTRVNQPSIEGTRTFQQYWSVRKEKRVGGTVTTTKHFDEWAKQGMKLGTYDSVIVAVEGYTAANGGSGSSGSASITIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PFH4</accession>
    <name>A0AAN6PFH4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_46669</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854388">
        <property type="protein sequence ID" value="KAK4039941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PFH4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF31">
        <property type="entry name" value="LAEA-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G01930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="47"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4039941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="366" mass="40421" checksum="63AFFED944663883" modified="2024-10-02" version="1">MTGSPPTSSPDRATPPKSPPGTASGSTPASPGASAPGPAPLTGTGHLEVDPDLVGHEAGDDADSTMSSRAGLSDTTSVMSSIFKFREENGRTYHTYRAEGQEIGLHPRGLRSNRPLDLQHYMCVQMQDNRLYVSPAGKGNPLNRVLDLGTGTGIWAIDLADEHPETSVAGVDLSPIQPDCIPPNLEFFIDDVERDWNYHTKFDLVYGRMLTGSIRDWPRLMAQAFENINPGGYLELCDSLNPLQSDDGSLKEDSAILKWNRLLVEASDKLGPSLKSALHYKQQMTDAGFEDVTQIEFKWPLNPWPRDAKYKELGEWNYFNVLQGIQAVSLMLFTNVLGWTVAEVEVLLTQVRKEAKNRDIHAYWPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PG68</accession>
    <name>A0AAN6PG68_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_17291</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854423">
        <property type="protein sequence ID" value="KAK4038641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PG68"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043020438" evidence="2">
        <location>
            <begin position="20"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4038641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="101" mass="9999" checksum="75F7AF6686BBFBEA" modified="2024-10-02" version="1">MKCTIATVLSVLFATQAAAQGVTISLPSGVSLPSGVTLPSGVSVVTASSTSSTAQANRRYHKRQGGGTGGGFTGISGFSIGQQTRTNNGAQQTGQAGRNNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PGD3</accession>
    <name>A0AAN6PGD3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11 12">Endo-1,4-beta-xylanase</fullName>
            <ecNumber evidence="4 11 12">3.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">C8A01DRAFT_16545</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11 12">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
            <dbReference type="EC" id="3.2.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11 12">Glycan degradation; xylan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11 12">Belongs to the glycosyl hydrolase 11 (cellulase G) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.8" evidence="4 11 12"/>
    <dbReference type="EMBL" id="MU854399">
        <property type="protein sequence ID" value="KAK4039510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PGD3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013319">
        <property type="entry name" value="GH11/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018208">
        <property type="entry name" value="GH11_AS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033119">
        <property type="entry name" value="GH11_AS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033123">
        <property type="entry name" value="GH11_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001137">
        <property type="entry name" value="Glyco_hydro_11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46828">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46828:SF2">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00457">
        <property type="entry name" value="Glyco_hydro_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00911">
        <property type="entry name" value="GLHYDRLASE11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00776">
        <property type="entry name" value="GH11_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00777">
        <property type="entry name" value="GH11_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51761">
        <property type="entry name" value="GH11_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11 12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9 11 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 11 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 11 12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11 12" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042862886" description="Endo-1,4-beta-xylanase" evidence="13">
        <location>
            <begin position="20"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="GH11" evidence="14">
        <location>
            <begin position="37"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK4039510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="236" mass="25357" checksum="B169379EF71BBE4F" modified="2024-10-02" version="1">MISLKALLFQVLGASTAVALPSPGPSSNPLPSLLSSRGTPISNGISNGFFYSFWTDGGGDVNYQNGADGSYSVRWANCSSFYGGKGWMPGRADRSITYSGTFNPEGNGYLSVYGFAKNPLLEYYIIESYGTFDPTLLFQGGSGNQSSVLEVDGGSYRLGMKRVVRMELGSGAVLTQVYSVRDKGDRRQEGTVNIKAHFDAWKEKLGVRIGTLDFQIVATEGYQSSGVAEIEVEQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PGR0</accession>
    <name>A0AAN6PGR0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acetamidase regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_37813</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854435">
        <property type="protein sequence ID" value="KAK4038230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PGR0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF81">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="135"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="179"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4038230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="674" mass="74093" checksum="3E00FF015C488E18" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PH61</accession>
    <name>A0AAN6PH61_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SMP-30/Gluconolactonase/LRE-like region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_15358</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854369">
        <property type="protein sequence ID" value="KAK4040796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PH61"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052998">
        <property type="entry name" value="Hetero-Diels-Alderase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42060:SF1">
        <property type="entry name" value="NHL REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42060">
        <property type="entry name" value="NHL REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042843707" description="SMP-30/Gluconolactonase/LRE-like region domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4040796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="342" mass="35615" checksum="A71ED096161ECFA2" modified="2024-10-02" version="1">MRPFLYISTFLAAACGAQASGGHTQPPIRNIFTFPKNTFIENIAVRANSNLVITSLSVPTLFSINPTLPNATAPVIYTFPNATGISGIAEITPDLFALVTGVWDLANTRAILGSLAIWTIDFTTTKPPNSAPKVKFITTVPNSTVLNGIAAHPSNPRLLLAADSALGAVWRVDLATGAHDVAFSSPLLAPTSEGHLGINGLKAAGEHVYFTNSAQGLLGRVKIDREGGPKGEVEVLAKAAEAGADVVYDDFALDFSFSKRGKDPKGVWIASHPSYAVRVALAGAGAGGQWVVNDTGKLLNPTSAALGRGSGRQERTLYVTNGGEFVGADLVNEGVVAVDLGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PHD7</accession>
    <name>A0AAN6PHD7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Histone H2B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">C8A01DRAFT_34979</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the histone H2B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854365">
        <property type="protein sequence ID" value="KAK4041034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PHD7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22910">
        <property type="entry name" value="HFD_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000014">
        <property type="entry name" value="Histone H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000558">
        <property type="entry name" value="Histone_H2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055333">
        <property type="entry name" value="HISTONE_H2B_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23428">
        <property type="entry name" value="HISTONE H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00621">
        <property type="entry name" value="HISTONEH2B"/>
    </dbReference>
    <dbReference type="SMART" id="SM00427">
        <property type="entry name" value="H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00357">
        <property type="entry name" value="HISTONE_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6 13" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="12 13" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="11 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="15">
        <location>
            <begin position="31"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK4041034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="136" mass="14722" checksum="F30C96F0D69BC24C" modified="2024-10-02" version="1">MPPKADKKPAAKAPVASKAPADKKDAGKKTAAPGEKKKRGKTRKETYSSYIYKVLKQVHPDTGISNRAMSILNSFVNDIFERVATEASKLAAYNKKSTISSREIQTSVRLILPGELAKHAVSEGTKAVTKYSSSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PHP5</accession>
    <name>A0AAN6PHP5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">AP complex subunit sigma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">C8A01DRAFT_15065</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type subunit APL3 and beta-type subunit APL1), a medium chain (mu-type subunit APM4) and a small adaptin (sigma-type subunit APS2).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <location evidence="2">Coated pit</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854362">
        <property type="protein sequence ID" value="KAK4041184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PHP5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030122">
        <property type="term" value="C:AP-2 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14833">
        <property type="entry name" value="AP2_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000011">
        <property type="entry name" value="AP complex subunit sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016635">
        <property type="entry name" value="AP_complex_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027156">
        <property type="entry name" value="APS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11753">
        <property type="entry name" value="ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015588">
        <property type="entry name" value="AP_complex_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0168">Coated pit</keyword>
    <keyword evidence="6" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="13">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00062168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR015588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK4041184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="143" mass="16927" checksum="E80FD12250E5647F" modified="2024-10-02" version="1">MLSFILIQNRQGKTRLAKWYVPYSDDEKIKLKGEVHRLVAPRDQKYQSNFVEFRNHKVVYRRYAGLFFCACVDTNDNELAYLEAIHFFVEVLDSFFGNVCELDLVFNFYKVYAILDEVFLAGEIEETSKQVVLTRLEHLDKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PHP9</accession>
    <name>A0AAN6PHP9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mesaconyl-C4 CoA hydratase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_15124</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854364">
        <property type="protein sequence ID" value="KAK4041081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PHP9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019171">
        <property type="term" value="F:(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052741">
        <property type="entry name" value="Mitochondrial_HTD2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28152">
        <property type="entry name" value="HYDROXYACYL-THIOESTER DEHYDRATASE TYPE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28152:SF1">
        <property type="entry name" value="HYDROXYACYL-THIOESTER DEHYDRATASE TYPE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4041081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="385" mass="42210" checksum="E99E61DD445697F4" modified="2024-10-02" version="1">MRPSILTPLLRRYKPRLTLPSLQPILNHAPYSSSSTPFNPETYLHAARQKFASQPPTLIPDTLSPTPSHLLTLSLADHVPALFPPTTTQQLSHPLSYPGAENEESPILPQGHHLVYFPLQLPPSKLMPDGTDPAHWPGAPFVRRMWAGGEVVFREGWEKAMRVDGRRAVCVERVGEEPVLKMGRGEGAEKVFVEVRRSYYGVDGERVGGDGVVEEVRRLVFMRGRELGGGGQAVVGGRVVKASATPEFTFSLKPDATLLFHFSALTYNAHSIHIDPDYARNREGYKGLLVHGPLSLVLMLSALRACLAKVSAQPPTGSTPEEGQSMPYVKSLSYRNLAPLYVDEQMKVCLRRTKSEGDQLGWDVWIEGPEGGLAVKGNAVTTGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PJG8</accession>
    <name>A0AAN6PJG8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Metallo-dependent phosphatase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_16387</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the 5'-nucleotidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854395">
        <property type="protein sequence ID" value="KAK4039655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PJG8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07409">
        <property type="entry name" value="MPP_CD73_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000020">
        <property type="entry name" value="NT5E isoform 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="entry name" value="5'-Nucleotidase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008334">
        <property type="entry name" value="5'-Nucleotdase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006146">
        <property type="entry name" value="5'-Nucleotdase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575:SF24">
        <property type="entry name" value="5'-NUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="5'-NUCLEOTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02872">
        <property type="entry name" value="5_nucleotid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01607">
        <property type="entry name" value="APYRASEFAMLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00786">
        <property type="entry name" value="5_NUCLEOTIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042661685" evidence="6">
        <location>
            <begin position="17"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="7">
        <location>
            <begin position="41"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="5'-Nucleotidase C-terminal" evidence="8">
        <location>
            <begin position="341"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4039655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="561" mass="61307" checksum="CC314BD728B4941A" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PJH7</accession>
    <name>A0AAN6PJH7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_14500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854351">
        <property type="protein sequence ID" value="KAK4041802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PJH7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39609">
        <property type="entry name" value="RFEG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39609:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR RFEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4041802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="129" mass="14761" checksum="7A6E75777D58F7A2" modified="2024-10-02" version="1">MSSSSSMNKYWIPHLDIHKKVITQELQFYLGPEATVRSFTRDGEDGFLITTPGACLTDEQIDDICVKSKEMWEKQAAARAAGAATRVLKRPLHQPVVISKAGASESTRRRRESRRSNETRSRRDERRRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PJN4</accession>
    <name>A0AAN6PJN4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_15835</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854381">
        <property type="protein sequence ID" value="KAK4040259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PJN4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF13">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATORY PROTEIN MOC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="304"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="199"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="344"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="419"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="141"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="345"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="358"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="369"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4040259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="756" mass="81423" checksum="EA22B4B2E2B137B0" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PJN5</accession>
    <name>A0AAN6PJN5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">P-type Cu(+) transporter</fullName>
            <ecNumber evidence="3">7.2.2.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Cu(2+)-ATPase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">C8A01DRAFT_33725</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="17">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.8" evidence="3"/>
    <dbReference type="EMBL" id="MU854344">
        <property type="protein sequence ID" value="KAK4042228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PJN5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043682">
        <property type="term" value="F:P-type divalent copper transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140581">
        <property type="term" value="F:P-type monovalent copper transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055070">
        <property type="term" value="P:copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="CDD" id="cd02094">
        <property type="entry name" value="P-type_ATPase_Cu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000001">
        <property type="entry name" value="ATPase copper transporting beta"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000002">
        <property type="entry name" value="Copper-transporting ATPase 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000137">
        <property type="entry name" value="Heavy metal translocatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006122">
        <property type="entry name" value="HMA_Cu_ion-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00003">
        <property type="entry name" value="copper ion binding protein"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520">
        <property type="entry name" value="ATP7, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520:SF8">
        <property type="entry name" value="P-TYPE CU(+) TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00942">
        <property type="entry name" value="CUATPASEI"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0186">Copper</keyword>
    <keyword evidence="9" id="KW-0187">Copper transport</keyword>
    <keyword evidence="14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="376"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="408"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="451"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="480"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="662"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="704"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1050"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1079"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="18">
        <location>
            <begin position="18"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="18">
        <location>
            <begin position="112"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="18">
        <location>
            <begin position="202"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="18">
        <location>
            <begin position="284"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00080126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAK4042228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1161" mass="122577" checksum="E88CE167A5E2AD6C" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PJS4</accession>
    <name>A0AAN6PJS4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_14091</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854343">
        <property type="protein sequence ID" value="KAK4042288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PJS4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="47"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4042288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="473" mass="51921" checksum="082C7A3D2553D84F" modified="2024-10-02" version="1">MRLFVLSPDSRSDGSPSGSRTQLIGNRAWSLVELDLRPNPDGHGADFVCVSYSWGLGRTPSAFHPSSLVSDRTEGAVAAVVEQRPACRSIWVDAFCVPSEEEHPAERAATLESMGFIYAQAAEVIVVLTAQARPAIEQLARKHKLLPAHLDLLEQEDWVTRAWTYQEAVNARHLSLTCENAPRGTIVSCSDFLSSLGHALVALHPDERAASYPRLDAFEDVMGDWAVAGYLERSALQVMAIMDRRTQTRPEDHFYAMIGALSAEPAGMKPLQQQQLASPCEAFMALCEREGDYSFIFASVKRDMTMPGRWWRPVAGPELPAIIRLSSWGGLRGRFEDGCLTLEDVVVLRPAPALPHLAVFIEEFVVGFRPDGAYAGLEPGEAAFKVLQELGFSGTSEYVATEYGLFFPWERLPRRDGVEILVAVGLRWSLGAAAIARYAKSSESDDVVSCYEPGVFFGTMVDLVGSPVTVRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PKB9</accession>
    <name>A0AAN6PKB9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">NWD NACHT-NTPase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_33415</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854340">
        <property type="protein sequence ID" value="KAK4042476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PKB9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031359">
        <property type="entry name" value="NACHT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF16">
        <property type="entry name" value="GPI INOSITOL-DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17100">
        <property type="entry name" value="NACHT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NWD NACHT-NTPase N-terminal" evidence="4">
        <location>
            <begin position="37"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="5">
        <location>
            <begin position="319"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="804"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="889"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="959"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1015"/>
            <end position="1038"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4042476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1053" mass="116112" checksum="5D3C5A03A41AE409" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PKI0</accession>
    <name>A0AAN6PKI0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_34152</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854351">
        <property type="protein sequence ID" value="KAK4041773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PKI0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF130">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="256"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="280"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="317"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="1"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4041773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="382" mass="40652" checksum="F033D0C4128A930D" modified="2024-10-02" version="1">MNTWGVFISFGVFQSYYIPTLALPPSTISWIGSTSVFLLFLAGSAAGVLTDAGFFRATVASGAALVVLGTFATSVSTTAYWHVFLAQGVCTGLGNGLLFAPSMTVVSTYFARRRGVALAVAASGSSVGGLVFPSMARTLLPRVGFGWTMRAIGFVQLGTLAVGLAVARTREMPRGKGPLFDWAAWREPEYALYAVGAFLTFIGIFFPFFYLASYARDIQHLSYPDSLNLLLVLNGVGVVARLFPGFLALWVGTYNVFIVLVAITSLTLYCWAAVSSLGGLYAWTVFFSLSMGGVQALFPAALAALKFDAQKQGTRMGMLFAVIGFGCLIGPPISGVLIRNSGGDYLDAQMFSGSCMVAGLVLLVAAREVKRRREGLKLLAKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2025-10-08" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PM54</accession>
    <name>A0AAN6PM54_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mannosyl-oligosaccharide glucosidase</fullName>
            <ecNumber evidence="1">3.2.1.106</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Glucosidase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_43515</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>N(4)-(alpha-D-Glc-(1-&gt;2)-alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + H2O = N(4)-(alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:55988"/>
            <dbReference type="Rhea" id="RHEA-COMP:12806"/>
            <dbReference type="Rhea" id="RHEA-COMP:14355"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:59082"/>
            <dbReference type="ChEBI" id="CHEBI:132537"/>
            <dbReference type="EC" id="3.2.1.106"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Glycan metabolism; N-glycan degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 63 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.106" evidence="1"/>
    <dbReference type="EMBL" id="MU854326">
        <property type="protein sequence ID" value="KAK4043569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004573">
        <property type="term" value="F:Glc3Man9GlcNAc2 oligosaccharide glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009311">
        <property type="term" value="P:oligosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031335">
        <property type="entry name" value="Glyco_hydro_63_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004888">
        <property type="entry name" value="Glycoside_hydrolase_63"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054491">
        <property type="entry name" value="MGH1-like_GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412:SF10">
        <property type="entry name" value="GLYCOSYL HYDROLASE FAMILY 63 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03200">
        <property type="entry name" value="Glyco_hydro_63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22422">
        <property type="entry name" value="MGH1-like_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="1" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="3">
        <location>
            <begin position="212"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="45"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1559"/>
            <end position="1632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1589"/>
            <end position="1605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU369107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4043569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1681" mass="189761" checksum="F7FCFE76F3730DBC" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PM69</accession>
    <name>A0AAN6PM69_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_34894</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854364">
        <property type="protein sequence ID" value="KAK4041050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PM69"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF105">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="407"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="56"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="415"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4041050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="443" mass="49332" checksum="AEAA8ADD5ED70B84" modified="2024-10-02" version="1">MSSVQAGGYSGTQDAQSGEHPSTPQRQTHTTEVDDSIISPEVRALLALDAESIGLEVDEDEDEDGDDEVDEAQDSARSVYAMSMYPGVGPAYQVEHPYENGQDSATIDSARTLYAEDFDFVVEHGRQYCGDYFLPIDQTEQTRQYVIHQVYLKVFGLELTTVPLENPRYVLDIGTGIGEWAIGMAEKYPQCEVFGTDIAPIQPTHQVPFNIEFHIENAEDEWIRPADAVDLVHLRHMEGAFSDWSFIYNQAFECIKPGGWIEIVDWEDFFADKNYLSFFPEGSAPHVLTRALLEAAELAGKPRDSRHLSRDLLAAAGFVDIQESVYDLGIGSRENSSYGTFWLFSIVTGVEATSLRLLTKYLGWDADEVRKLCEKVAQETKAVADNSARVDAFVVKLRVISGRKPLAPGQWPDRALNENGDKKDHSGDESTIGARTIRSEETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PMG8</accession>
    <name>A0AAN6PMG8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Magnesium transporter protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">C8A01DRAFT_13746</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the OST3/OST6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854338">
        <property type="protein sequence ID" value="KAK4042598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PMG8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000302">
        <property type="entry name" value="Oligosaccharyl transferase subunit (Gamma), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021149">
        <property type="entry name" value="OligosaccharylTrfase_OST3/OST6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12692">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12692:SF0">
        <property type="entry name" value="GH11935P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04756">
        <property type="entry name" value="OST3_OST6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042940811" evidence="10">
        <location>
            <begin position="21"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="269"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="298"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK4042598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="334" mass="36578" checksum="E6772D3B3D7E7D66" modified="2024-10-02" version="1">MRLLTLLSLTLLGGVTGSLAAASAKKTPQERFQLYHAKSLSSSPVKLSDPSYRELTATPRDYAVAVLLTAMDARYGCQLCREFQPEWELLARSWTGGDKAGESRVVFGTLDFGDGRDIFMSLGLQTAPVLFFFPPTAGPHAAASAEPIRYDFTGGAQAAEVVHSWVARHLPDRPHPPIKRPINWMRWISSLVILSGGLTVSFVAWPYVLPVIQSRTVWAAVTLISILLFTSGHMFNHIRNVPYVAGDGRGGISYFASGFQNQYGLETQIVAAMYGILALSSISLAIKVPRMSDPRAQGVAFIAWFGILFVVYSLLLSIFRGKNPGYTFSLPPFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PMH1</accession>
    <name>A0AAN6PMH1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sterol 24-C-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_43608</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854327">
        <property type="protein sequence ID" value="KAK4043482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PMH1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050723">
        <property type="entry name" value="CFA/CMAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43667">
        <property type="entry name" value="CYCLOPROPANE-FATTY-ACYL-PHOSPHOLIPID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43667:SF2">
        <property type="entry name" value="FATTY ACID C-METHYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="2">
        <location>
            <begin position="76"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4043482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="244" mass="26336" checksum="4D2386F37236BAD9" modified="2024-10-02" version="1">MSDLAPHPSTPPNLKARVKASYDAIAPAYNAWTTSHNVLRERYLARLLEHVQPPGTTPGSSSVDSTETNNPTKTALDLGCGAGVPSTAALLAAGLRVQANDLSTTQLALARARFADETRDGRVEWLEGDMMALEFAPASLDAVVALYSLVHLTREEQAAMVGRVAGWLRPGGVVLVNFGLEETEGVTVERWLGRDEGWMYWSAWGAEKSLGVVREAGLEVLVEEISPPLGDSEAEFLWVIARKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PMY3</accession>
    <name>A0AAN6PMY3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1749-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_12583</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854322">
        <property type="protein sequence ID" value="KAK4043946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PMY3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013744">
        <property type="entry name" value="SidJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31591:SF7">
        <property type="entry name" value="DUF1749-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31591">
        <property type="entry name" value="UPF0613 PROTEIN PB24D3.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08538">
        <property type="entry name" value="DUF1749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4043946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="323" mass="35346" checksum="6D408E0474D94E1C" modified="2024-10-02" version="1" fragment="single">PKMSNPPIPRPHPVQVHHYLPSSSSTTNEPPHPLQTYEHTYFHPAQVPAPSNALVFIGGLGDGPHTIPYVQSLVRPLSTLPSDRDDIYNGRYSVFEARLSSAFTGFGHGSLAQDAREIADLVRYLRRGLGMRRVVLMGHSTGCQDCLEYAAVTKSLDDGGEEEEEELEEAWATRVDGYILQGPVSDREAIQMGEDPVEVAGSLRVARGMGWRGSPVTAYRWASLAGVGGDDDYFSSDLSDDKLAAIWGRLERPVLIVPSEKDEWVPAGTDVMGLVRKWMGFCKPGIASELSGLIPGANHRVDNEAGQQWLADRVARFLAEIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PN25</accession>
    <name>A0AAN6PN25_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_31661</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854321">
        <property type="protein sequence ID" value="KAK4044064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PN25"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4044064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="284" mass="30114" checksum="47F57F9250210CDD" modified="2024-10-02" version="1">MAQKQENWKWCSKCACIFFGGDAVCRANNGVHDLSGSAMYTISFQSGAPGQDKWKWCKKCQVLSYTGNTIGACQAGGQHDVSSSGDYHLPSSGGGQKPWRWCHKCQGLAWQPAACTAGGNHDFAGSGEYHVCMDGEPRAQAAIGQDGWRWCKNCQLLCFDGKTSCAAGGAHISAGSGNYEISFAQQQANAQSGWKWCNKCYGLAFSQSASDGVCPRGGTHGFESSGNYAVLVNVAPAGGQQDKWAWCSHCQQMWYSGNGAGRCPGVPNGGHSKDGSGAYVLQFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PNA1</accession>
    <name>A0AAN6PNA1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ricin B lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_31790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854321">
        <property type="protein sequence ID" value="KAK4044184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PNA1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="beta-trefoil_Ricin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042997940" description="Ricin B lectin domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B lectin" evidence="2">
        <location>
            <begin position="26"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4044184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="166" mass="17901" checksum="2D136D626CE18B80" modified="2024-10-02" version="1">MLGTAVLLLSLAATGLAQAPEGYRTVYITSNVNTKFVIVPKARTTGSTTIVKTRNDKPEQQWYLKDGASKIQLANSTLCMDGGANSNWKDMGKIYVNECAETESQKWFVMADGRIALEPSGQKQCVDLVYMRATENNDVGLYSCAGLGNTGAADKGINWPLVNVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PNZ2</accession>
    <name>A0AAN6PNZ2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RGS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_12949</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854326">
        <property type="protein sequence ID" value="KAK4043560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PNZ2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39466">
        <property type="entry name" value="RGS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39466:SF1">
        <property type="entry name" value="RGS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="242"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="321"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4043560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="349" mass="39132" checksum="F3AA088704D9BD1A" modified="2024-10-02" version="1">MPDSEHAPKPKTQYGDIPAELSFEEVIKNRTAPPCSLNDFVDYLFYVEHNAETLQFFLWYWDYIQRWSSLLPRQKALSPPWDPEQATEPRSRFIKYSHKRERSLKMNKVLAIMEMDSERASLDPSPQDDTGSSPVITSPIASPTAILSPTGSIKPSDWQPFTIQPNRTELSRITRHYICPSAPRHLRLSQKDRAACLRAVQHTTHPSALLPAFLTSEATLRAHSHPAFIRWARRNANPSRVLFLRILGCLLLLLGVAVDVILILSGLSAYWRVALQVFGPANEYAGEAWMAGYESKGLVGRVFDETVVVQNQALATWQDRAVFFALLWGGAGSAALTVVSLFVPSGSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PPE3</accession>
    <name>A0AAN6PPE3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-hydroxyisobutyryl-CoA hydrolase</fullName>
            <ecNumber evidence="3">3.1.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">3-hydroxyisobutyryl-coenzyme A hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_11855</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-methylpropanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20888"/>
            <dbReference type="ChEBI" id="CHEBI:11805"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57340"/>
            <dbReference type="EC" id="3.1.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.4" evidence="3"/>
    <dbReference type="EMBL" id="MU854316">
        <property type="protein sequence ID" value="KAK4044778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PPE3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003860">
        <property type="term" value="F:3-hydroxyisobutyryl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000026">
        <property type="entry name" value="3-hydroxyisobutyryl-CoA hydrolase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045004">
        <property type="entry name" value="ECH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032259">
        <property type="entry name" value="HIBYL-CoA-H"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004127">
        <property type="entry name" value="PRK05617.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176:SF3">
        <property type="entry name" value="3-HYDROXYISOBUTYRYL-COA HYDROLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176">
        <property type="entry name" value="3-HYDROXYISOBUTYRYL-COA HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16113">
        <property type="entry name" value="ECH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl-CoA hydratase/isomerase" evidence="7">
        <location>
            <begin position="47"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4044778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="492" mass="54868" checksum="0DA217FC59BA0C95" modified="2024-10-02" version="1">MPLRAKLLSQQPQSQRLLSTQAAYDRFKPRDGDEPEDVLFNSLYGLRSIELNRPKKLNALNGSMIRKIAPRMLEWAKSDMASVIVMKGAGDKAFCAGGDVAQLAQWNQAGPQGQERSKEYFAQEYQLDHLIATFNKPYIAFMDGITMGGGVGLSVHAPFRIATERTVFAMPETTIGFFPDVGASFFLPRMPGAVGTYLALTSSRLTGANVLYAGIATHYLHSTSLPRLESRLAELRFQDYDEMETRLAAIDATIEEFVTGLPHDEPILLGGEVRRAIDRCFSHDSVDQILRALEQERGATRQWAEETLATLHKRSPTAVHVALRQMRIGAKWSIRDTYIREHAMAGKFMASHDFTEGVTALLVDKRAPRWQPASLEDITPEQSPNLTEDFFLMPRRAPKLDLQADGPEVVRGASRLELLTHADYDEYPFAHFGVPSEADVEKKVSLGTMTRAQVLDAFVRERGQKQGVKEVVEEILARKTTGGAQAVAKWVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PPL6</accession>
    <name>A0AAN6PPL6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Siderophore iron transporter mirC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_12017</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854317">
        <property type="protein sequence ID" value="KAK4044607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PPL6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015343">
        <property type="term" value="F:siderophore-iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000197">
        <property type="entry name" value="Siderophore iron transporter 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF87">
        <property type="entry name" value="SIDEROPHORE IRON TRANSPORTER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="311"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="347"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="385"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="417"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="446"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="488"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="565"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="61"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4044607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="632" mass="67563" checksum="730BA354E5937B2A" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PQF6</accession>
    <name>A0AAN6PQF6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_32873</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854332">
        <property type="protein sequence ID" value="KAK4043081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PQF6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16620">
        <property type="entry name" value="vRING-HC-C4C4_RBBP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014891">
        <property type="entry name" value="DWNN_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033489">
        <property type="entry name" value="RBBP6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025829">
        <property type="entry name" value="Zn_knuckle_CX2CX3GHX4C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15439:SF0">
        <property type="entry name" value="CELL DIVISION CYCLE AND APOPTOSIS REGULATOR PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15439">
        <property type="entry name" value="RETINOBLASTOMA-BINDING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08783">
        <property type="entry name" value="DWNN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13696">
        <property type="entry name" value="zf-CCHC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01180">
        <property type="entry name" value="DWNN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51282">
        <property type="entry name" value="DWNN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DWNN" evidence="9">
        <location>
            <begin position="5"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="8">
        <location>
            <begin position="180"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="357"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="581"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="366"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="401"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="581"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="591"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="640"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4043081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="660" mass="70899" checksum="8A2E84F207DD42F3" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PS28</accession>
    <name>A0AAN6PS28_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytoplasmic tRNA 2-thiolation protein 1</fullName>
            <ecNumber evidence="6">2.7.7.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Cytoplasmic tRNA adenylyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">NCS6</name>
        <name evidence="6" type="synonym">CTU1</name>
        <name evidence="11" type="ORF">C8A01DRAFT_31578</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TtcA family. CTU1/NCS6/ATPBD3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.-" evidence="6"/>
    <dbReference type="EMBL" id="MU854320">
        <property type="protein sequence ID" value="KAK4044264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PS28"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002144">
        <property type="term" value="C:cytosolic tRNA wobble base thiouridylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032447">
        <property type="term" value="P:protein urmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01713">
        <property type="entry name" value="CTU1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000132">
        <property type="entry name" value="Cytoplasmic tRNA 2-thiolation protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03053">
        <property type="entry name" value="CTU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056369">
        <property type="entry name" value="CTU1-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032442">
        <property type="entry name" value="CTU1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000541">
        <property type="entry name" value="Ncs6/Tuc1/Ctu1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035107">
        <property type="entry name" value="tRNA_thiolation_TtcA_Ctu1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020554">
        <property type="entry name" value="UPF0021_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11807">
        <property type="entry name" value="ATPASES OF THE PP SUPERFAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11807:SF12">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16503">
        <property type="entry name" value="zn-ribbon_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004976">
        <property type="entry name" value="ATPase_YdaO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01263">
        <property type="entry name" value="UPF0021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 6" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2 6" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal" evidence="9">
        <location>
            <begin position="53"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Cytoplasmic tRNA 2-thiolation protein 1 C-terminal" evidence="10">
        <location>
            <begin position="370"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="338"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="57"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR004976-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK4044264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="402" mass="44135" checksum="FD08162B7E860540" modified="2024-10-02" version="1">MAPALCANCKTERALIKRPKNHAKLCKACFIAVFEDEVHHTITSSQLFYPGEKVAIGASGGKDSTVLASVLKTLNERHGYGLDLVLLSIDEGIKGYRDDSLETVKRNAAQYDMPLKVVGYEELYGWTMDQVVETIGKKGNCTYCGVFRRQALDRGAKMLEIKHVVTGHNADDVAETVLMNLLRGDLARLSRSTSIVTGDSRSEVKRSKPLKYSYEKEIVLYAHHKKLDYFSTECIYSPEAFRGSARGLIKQLERVRPTAILDIVRSGEDMARLVPGESPSSCACKGQKRAAMAPAEDDVGGCGSQNGRTPGNEMAAMDKQLRENEANEGLEIDVGKAMSESKMSGSEKQRDLPIRSGNGASKAVPRQVRGNCKRCGYMSSQDICQACMLLEGLNKNRAQIQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PTR8</accession>
    <name>A0AAN6PTR8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_31477</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854319">
        <property type="protein sequence ID" value="KAK4044425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PTR8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4044425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="177" mass="21113" checksum="0FE2F6A420E30F8D" modified="2024-10-02" version="1">MVLGRWEVCEAIQFNSWTAVQGWYYRVAWGAFLGLRDDYLAPFDRRGERSPPGNWRIKEFFVRSAEKLDQRVDRRVAELEAGVFRPDPNKEGWGTKRHYEEFIVEALALDRLSARRNPEKNHISTREYARDPVKLFANMYELTDAICHNHWKPETDQWDSDDSDIPYTNEEDLRDWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SLC3</accession>
    <name>A0AAN6SLC3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_51402</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854763">
        <property type="protein sequence ID" value="KAK4031557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SLC3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF51">
        <property type="entry name" value="QUINIDINE RESISTANCE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="259"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="293"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="40"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4031557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="386" mass="42063" checksum="F5C425A290B20349" modified="2024-10-02" version="1">MSDDMERAATLVSSDPANQEQPPASKPLYSVFSSSEKRMMTALAGFAMLFSPLTANIYFPAMNQLETDLGASVQLINLTITSYLVLQAVASALFGDLADVVGRRPAFLAMFAVYTAANLGLALQRSFPALLTLRMVQSLGASATAAVSYGLVADLVTAGERGGVIGVTMIATNLGPTLAPLIGGAILGGSGSWQWIFWFLLVCGAFELLLLLLLLSETARSIVGNGRIRPPVWRRPLLSRRIPNPLRSPRVMFYKDSSLILLIRGVFYMIYYCLQASIALMFRQHYPQFSDTVIGACYPSIGCGVVVGGYLNGRLLNRNYAVTAEEIDHVGVDKNDNDLNRFPIERARLRSMTYLQLLHLGPMVGYGWVMQKDVVSCKIMDEALGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SLP9</accession>
    <name>A0AAN6SLP9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Prion-inhibition and propagation HeLo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_51135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854673">
        <property type="protein sequence ID" value="KAK4031948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SLP9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1020">
        <property type="entry name" value="Prion-inhibition and propagation, HeLo domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029498">
        <property type="entry name" value="HeLo_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038305">
        <property type="entry name" value="HeLo_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37542">
        <property type="entry name" value="HELO DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37542:SF3">
        <property type="entry name" value="PRION-INHIBITION AND PROPAGATION HELO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14479">
        <property type="entry name" value="HeLo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prion-inhibition and propagation HeLo" evidence="1">
        <location>
            <begin position="8"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4031948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="664" mass="74828" checksum="2D692214C13CBD64" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SM19</accession>
    <name>A0AAN6SM19_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_20610</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854626">
        <property type="protein sequence ID" value="KAK4032293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SM19"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990526">
        <property type="term" value="C:Ste12p-Dig1p-Dig2p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990527">
        <property type="term" value="C:Tec1p-Ste12p-Dig1p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052127">
        <property type="entry name" value="STE12_transcription_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47427">
        <property type="entry name" value="PROTEIN STE12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47427:SF1">
        <property type="entry name" value="PROTEIN STE12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="263"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="293"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4032293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="357" mass="38954" checksum="EF692224FEA1082E" modified="2024-10-02" version="1">MNLTSSPMCNIDPDSGANVNFGFNSLQAEGTEASVRPSSYPSSSFGPYIPTSGYSTPLPAPSHSGLPSSISFDFGSSFASLASVVPFRLILAPSTTFTYHPMAPKTDNASNQGRHDLSIQALGSYGAQLTSSQTMDCKLLANQPSPNSHLLTPSVITDLDDLSDNAAHQMYPDVPINFNQQVPTTLVGTVDRAMTTPFILPSTERDQVLIGEARHGTGLQQQVQRCSPSNSRSRIKRKKNRRAVVAGDSSFALDNVVKPAAAFKCPIKGCPKLYHRNEHVKRHIKTAHDRSTFPCKFCNHVANRSDNYMAHLKLHTKPRLKSGGSQPRVAFSEDAVLEFKTENESRRRGKEKLSKPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SM51</accession>
    <name>A0AAN6SM51_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Kinetochore Sim4 complex subunit FTA2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_50967</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854637">
        <property type="protein sequence ID" value="KAK4032190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SM51"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025213">
        <property type="entry name" value="Sim4_Fta2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13095">
        <property type="entry name" value="FTA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4032190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="285" mass="32241" checksum="A9D2383A8CA21EBB" modified="2024-10-02" version="1">MAGKGKKRQRGDRHLMPLPDCDGPKLHPFRHPHAQIEWLERLDADRASQSGPEGYVFKVRIESRIYALKVFKFFDPSSTEYYWGNIIGPSAVVSDVIFHTDPFYAECRAYGKINQAQKSRPGKRELAVRCHGYLLLQDRDTQSLLKRGVDLDMDIVDEELLRVNKEDGRVRAIVKDFVPGDSGVNAKSIRGILRDVRALNKLGVYVGDVRADNFRGGKLVDFGLSSTEPHCIMEALDEVGLRETKLEDLVMFDEMVVSEGLVTSARAMPNNAYCSKLRSWARKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SM69</accession>
    <name>A0AAN6SM69_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">26S proteasome regulatory subunit 6B homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">C8A01DRAFT_20217</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854578">
        <property type="protein sequence ID" value="KAK4032759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SM69"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000020">
        <property type="entry name" value="26S protease regulatory subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000049">
        <property type="entry name" value="26S protease regulatory subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000033">
        <property type="entry name" value="26S protease regulatory subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="198"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="58"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00068703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK4032759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="421" mass="47049" checksum="B0B00E6131DB5989" modified="2024-10-02" version="1">MGDVLVETAANSIQPLKKNTPSTIPSIENFEGVSTEGGDEYANLKRLQRQLEYIQLQEEYIKDEQRSLKRELVRAQEEIKRIQSVPLVIGQFMEAIDQNTGIVQSSTGSNYVVRILSTLDRELLKPSSSVALHRHSNALVDILPPEADSSIAMLGADEKPDVTYADVGGLDMQKQEIREAVELPLTHFDLYKQIGIDPPRGVLLYGPPGTGKTMLVKAVANSTTANFIRVVGSEFVQKYLGEGPRMVRDVFRMARENAPAIIFIDEIDAIATKRFDAQTGADREVQRILLELLNQMDGFDQTANVKVIMATNRADTLDPALLRPGRLDRKIEFPSLRDRRERRLIFTTIASKMSLAPEVDLDSLIVRNDPLSGAVIAAIMQEAGLRAVRKNRYNIIQVDLEDAYSSQVKGTSDENKFDFYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SMB7</accession>
    <name>A0AAN6SMB7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_49768</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854515">
        <property type="protein sequence ID" value="KAK4033686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SMB7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052973">
        <property type="entry name" value="Fungal_sec-metab_reg_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35392:SF3">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35392">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="231"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="84"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="185"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4033686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="634" mass="71985" checksum="AFC7CA181069E16A" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SMD2</accession>
    <name>A0AAN6SMD2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Major facilitator superfamily-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_40914</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854588">
        <property type="protein sequence ID" value="KAK4032637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SMD2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000196">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF193">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G00940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="114"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="174"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="251"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="289"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="489"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="24"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="518"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="519"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4032637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="540" mass="56941" checksum="C503EDBD939767B5" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SMX9</accession>
    <name>A0AAN6SMX9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Mitochondrial dicarboxylate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">C8A01DRAFT_50319</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854557">
        <property type="protein sequence ID" value="KAK4033030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SMX9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050391">
        <property type="entry name" value="Mito_Metabolite_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45618">
        <property type="entry name" value="MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="5"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="101"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="202"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK4033030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="298" mass="31877" checksum="7F606B7D8448B9D7" modified="2024-10-02" version="1">MAGQKGTKQPFWLGGAAASMAVCFTHPLDLTKYRMQVLQTRAPMLSTLYNFALRDGIPSLWSGLSASILRQSTYSTARFGLYSILSRQVQQRSGTKLSTASTVACAGVAGGLAGMVGNPTEVILVRMCADAAKPSAERFRYSDAVTGLYRIGKEEGIRVFGRGLSANIVRSVLMSKASCPPRVCGEYAAAKRAILAKTKLKDDIRTHALASLFAGTVATTACAPADVLKSRIQSAAKGASVMQVVREGLSREGPMFLMKGWTPAWLRLTPHTVLTFVIMEKLQELVNLAASTPARATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SN56</accession>
    <name>A0AAN6SN56_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GTPase-activating protein GYP5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">C8A01DRAFT_40153</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the GYP5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854533">
        <property type="protein sequence ID" value="KAK4033403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SN56"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.750:FF:000003">
        <property type="entry name" value="GTPase activating protein (Evi5)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000044">
        <property type="entry name" value="GTPase-activating protein GYP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF9">
        <property type="entry name" value="GTPASE ACTIVATING PROTEIN AND CENTROSOME-ASSOCIATED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23436">
        <property type="entry name" value="RabGap-TBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="3" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="12">
        <location>
            <begin position="375"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="409"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="744"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="56"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="160"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="194"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="258"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="297"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="409"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="429"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00072088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK4033403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="879" mass="96867" checksum="52B66796BCB02B69" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SN68</accession>
    <name>A0AAN6SN68_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Mitochondrial import inner membrane translocase subunit Tim21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">C8A01DRAFT_18645</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Required to keep the TOM and the TIM23 complexes in close contact. At some point, it is released from the TOM23 complex to allow protein translocation into the mitochondrial matrix.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the TIM23 complex, at least composed of TIM23, TIM17, TIM50 and TIM21.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
            <topology evidence="1 12">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the TIM21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854474">
        <property type="protein sequence ID" value="KAK4034571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SN68"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.320:FF:000002">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.320">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit Tim21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013261">
        <property type="entry name" value="Tim21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038552">
        <property type="entry name" value="Tim21_IMS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13032">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13032:SF6">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08294">
        <property type="entry name" value="TIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="12" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="21"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00060204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00063758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK4034571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="239" mass="26699" checksum="F5B7B94701DB3142" modified="2024-10-02" version="1">MNRVTVAGLRLRPSSTALPLQLARCPSSSPPSRSRRYATQHQQSSTAPESRRRAVTPFNDDGNVPWTDLSAGEKTARAAQQTFNFGMVVVGLVLTGGVGYVLYSEVFSPDSKTTHFNRAVDRIRTDPRCQELLGEGKKITAFGEETHNKWRRARPIASTISKDAQGNEHMMIQFNVQGPKGTGRVGMHLVKRAGQAEHEYKYFFVDIRGHQRIYLENADASRAKEGESKGFRMFGVKWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2025-10-08" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SNJ9</accession>
    <name>A0AAN6SNJ9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein SSH4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_49666</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854508">
        <property type="protein sequence ID" value="KAK4033823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12885">
        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044736">
        <property type="entry name" value="Gid1/RanBPM/SPLA_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF17">
        <property type="entry name" value="FUNGAL STAND N-TERMINAL GOODBYE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NACHT" evidence="4">
        <location>
            <begin position="340"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="925"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="1053"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="1087"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="1161"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="1197"/>
            <end position="1229"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="3">
        <location>
            <begin position="1273"/>
            <end position="1472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4033823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1505" mass="167509" checksum="14422EC48D7C246F" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SNP0</accession>
    <name>A0AAN6SNP0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_39174</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854483">
        <property type="protein sequence ID" value="KAK4034349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SNP0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4034349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="158" mass="17778" checksum="B11D264354D197BE" modified="2024-10-02" version="1">MSGRRAFSTAASKWKSLQWLNVTTSFTGSWGISLTEKYFDEAVKIKPQLKDKVALLRYARSNGNPHTTPGKLDPLHLSTKVGKHKDFSGSPLRLHIYPNGLIKPSEKDFPTLTAAPPSAAQLGEHAMWADEAYIAWWKEYQKARNEGRQVDESHEAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SP58</accession>
    <name>A0AAN6SP58_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Arf-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_38964</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854474">
        <property type="protein sequence ID" value="KAK4034572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SP58"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048205">
        <property type="term" value="P:COPI coating of Golgi vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08831">
        <property type="entry name" value="ArfGap_ArfGap2_3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000013">
        <property type="entry name" value="Putative Arf GTPase-activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45686:SF4">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45686">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="7">
        <location>
            <begin position="8"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="125"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="275"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="435"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="275"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="445"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4034572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="507" mass="52710" checksum="DABD19A18C01E6B3" modified="2024-10-02" version="1">MSGLASKQQSLKIFEKLKTKPANKVCFDCGQKNPTWTSVPLGIYLCLDCSANHRNLGVHISFVRSTNLDQWQWDQLRVMKVGGNESATKFFQSNGGSAALNSKDPKTKYTSAAATKYKEELKKRAARDAKEYPEEVVIDNAEGAESGSTPAEEEDDFFSSWSRPAVKKLSPPISRTATPPVVGRTPSPFLNAQNGKDTARAPSPLAKGTEGAAKPPPAASRITTSAALRSSTTGPRKANILGAKKVTSKLGAKKLGGGGGGGGGDLVIDFDEAEKKAKEEAERIEKLGYDPDAEEEAPAAGKTGGKSESAIVSPTPVSPARGGYGASHAREKSAAEVERLGMGIGRLGFGQVGKPAGAAAAAAQKKSGGGFGSVGPIKASAEDDGETYARKKFGTQKAISSDEFFGKGMFETGAQAEAKSRLQGFEGAQSISSNAYFGRPETDEGGMGGGGGRGGAGGEDYGDLESAAKDFVRRFGITAADDLENLSHLVGEGAGRLQGAIRDYLGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SP66</accession>
    <name>A0AAN6SP66_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_49032</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854472">
        <property type="protein sequence ID" value="KAK4034602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SP66"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052396">
        <property type="entry name" value="Meiotic_Drive_Suppr_Kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37171">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE YRZF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37171:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE YRZF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="446"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4034602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="798" mass="89530" checksum="BDAA846780CD3D50" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SP80</accession>
    <name>A0AAN6SP80_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_38996</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854476">
        <property type="protein sequence ID" value="KAK4034513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SP80"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042919547" evidence="1">
        <location>
            <begin position="19"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4034513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="163" mass="16861" checksum="5D61E0DC1ECE80FA" modified="2024-10-02" version="1">MHPVSLIALLTASASASASPRQSAPVNQNVIPKTFGVIAGEGKDKIQIGSCLGANNALIPCYCPPAPDSPEFLTKLAKALVDGFIFSKAQVAVPITLAKFNDESDRSAETNKLRATAMIEVMQNFNMTTQGVGCPGVSVPILGMMQQTGIVARGFGGLGNGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SP96</accession>
    <name>A0AAN6SP96_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_48956</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854468">
        <property type="protein sequence ID" value="KAK4034707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SP96"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF30">
        <property type="entry name" value="MID2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="172"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="246"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="297"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="382"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="433"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="646"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="178"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="246"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="321"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="341"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="394"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="448"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="514"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="612"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="663"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="687"/>
            <end position="697"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4034707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="697" mass="71856" checksum="4C1BAEB3C591F03B" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SPM1</accession>
    <name>A0AAN6SPM1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Sugar transporter STL1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">C8A01DRAFT_18297</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854459">
        <property type="protein sequence ID" value="KAK4034963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SPM1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015793">
        <property type="term" value="P:glycerol transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000061">
        <property type="entry name" value="MFS sugar transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF69">
        <property type="entry name" value="SUGAR TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="113"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="283"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="341"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="374"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="407"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="435"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="18"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="512"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="512"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="529"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK4034963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="562" mass="61493" checksum="B766923304F98219" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SQ30</accession>
    <name>A0AAN6SQ30_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bacterial low temperature requirement A protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_48336</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854443">
        <property type="protein sequence ID" value="KAK4035443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SQ30"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010640">
        <property type="entry name" value="Low_temperature_requirement_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42101">
        <property type="entry name" value="CHROMOSOME 16, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42101:SF1">
        <property type="entry name" value="LOW TEMPERATURE REQUIREMENT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06772">
        <property type="entry name" value="LtrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="140"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="211"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="461"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="493"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="524"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="557"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="629"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="569"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="629"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4035443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="693" mass="76431" checksum="0A72E9218A7114B2" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SQ32</accession>
    <name>A0AAN6SQ32_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BRO1-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_38086</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the palA/RIM20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854443">
        <property type="protein sequence ID" value="KAK4035458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SQ32"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09241">
        <property type="entry name" value="BRO1_ScRim20-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.560">
        <property type="entry name" value="alix/aip1 in complex with the ypdl late domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.50">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.280">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025304">
        <property type="entry name" value="ALIX_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004328">
        <property type="entry name" value="BRO1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038499">
        <property type="entry name" value="BRO1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030">
        <property type="entry name" value="PCD6 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030:SF39">
        <property type="entry name" value="PROGRAMMED CELL DEATH 6-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13949">
        <property type="entry name" value="ALIX_LYPXL_bnd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03097">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01041">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51180">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRO1" evidence="4">
        <location>
            <begin position="5"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="724"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="840"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="640"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="725"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="840"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="855"/>
            <end position="864"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4035458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="881" mass="98209" checksum="8A9940352187484B" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SQ50</accession>
    <name>A0AAN6SQ50_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fatty acid synthase subunit alpha</fullName>
            <ecNumber evidence="3">1.1.1.100</ecNumber>
            <ecNumber evidence="4">2.3.1.41</ecNumber>
            <ecNumber evidence="2">2.3.1.86</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="29" type="ORF">C8A01DRAFT_38114</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="30" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="30">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17397"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="1.1.1.100"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>a fatty acyl-[ACP] + malonyl-[ACP] + H(+) = a 3-oxoacyl-[ACP] + holo-[ACP] + CO2</text>
            <dbReference type="Rhea" id="RHEA:22836"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:14125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:138651"/>
            <dbReference type="EC" id="2.3.1.41"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>acetyl-CoA + n malonyl-CoA + 2n NADPH + 4n H(+) = a long-chain-acyl-CoA + n CoA + n CO2 + 2n NADP(+).</text>
            <dbReference type="EC" id="2.3.1.86"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 22">Belongs to the thiolase-like superfamily. Fungal fatty acid synthetase subunit alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="29">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="3"/>
    <dbReference type="EC" id="2.3.1.41" evidence="4"/>
    <dbReference type="EC" id="2.3.1.86" evidence="2"/>
    <dbReference type="EMBL" id="MU854444">
        <property type="protein sequence ID" value="KAK4035430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005835">
        <property type="term" value="C:fatty acid synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004321">
        <property type="term" value="F:fatty-acyl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042759">
        <property type="term" value="P:long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00828">
        <property type="entry name" value="elong_cond_enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08950">
        <property type="entry name" value="KR_fFAS_SDR_c_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.470.20:FF:000005">
        <property type="entry name" value="Fatty acid synthase alpha subunit FasA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2490:FF:000001">
        <property type="entry name" value="Fatty acid synthase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.25.70:FF:000001">
        <property type="entry name" value="Fatty acid synthase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="entry name" value="4'-phosphopantetheinyl transferase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00101">
        <property type="entry name" value="AcpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002582">
        <property type="entry name" value="ACPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040899">
        <property type="entry name" value="Fas_alpha_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047224">
        <property type="entry name" value="FAS_alpha_su_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026025">
        <property type="entry name" value="FAS_alpha_yeast"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041550">
        <property type="entry name" value="FASI_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050830">
        <property type="entry name" value="Fungal_FAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004568">
        <property type="entry name" value="Ppantetheine-prot_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00556">
        <property type="entry name" value="pantethn_trn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982:SF21">
        <property type="entry name" value="FATTY ACID SYNTHASE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982">
        <property type="entry name" value="MALONYL COA-ACYL CARRIER PROTEIN TRANSACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18325">
        <property type="entry name" value="Fas_alpha_ACP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18314">
        <property type="entry name" value="FAS_I_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000454">
        <property type="entry name" value="FAS_yeast_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="4'-phosphopantetheinyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 24" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10 24" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="15" id="KW-0520">NAD</keyword>
    <keyword evidence="13" id="KW-0521">NADP</keyword>
    <keyword evidence="14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 22 25" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 22" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="27">
        <location>
            <begin position="142"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="28">
        <location>
            <begin position="1089"/>
            <end position="1627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="97"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="26">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="active site" description="For beta-ketoacyl synthase activity" evidence="23">
        <location>
            <position position="1272"/>
        </location>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="1745"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="1746"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="1747"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="1848"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="25">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00049541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRNR" id="PIRNR000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PIRSR" id="PIRSR000454-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PIRSR" id="PIRSR000454-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PIRSR" id="PIRSR000454-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="EMBL" id="KAK4035430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1862" mass="203963" checksum="52B4FE0FCAB27398" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SQ76</accession>
    <name>A0AAN6SQ76_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transmembrane 9 superfamily member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">C8A01DRAFT_37825</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854435">
        <property type="protein sequence ID" value="KAK4038240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SQ76"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072657">
        <property type="term" value="P:protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004240">
        <property type="entry name" value="EMP70"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766:SF55">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02990">
        <property type="entry name" value="EMP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042673599" description="Transmembrane 9 superfamily member" evidence="9">
        <location>
            <begin position="24"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="310"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="411"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="446"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="481"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="511"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="573"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="602"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="644"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="677"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="348"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK4038240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="714" mass="78527" checksum="8E7BEE2C2ADD6572" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SQX9</accession>
    <name>A0AAN6SQX9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF8021 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_17075</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854417">
        <property type="protein sequence ID" value="KAK4038871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SQX9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058334">
        <property type="entry name" value="DUF8021"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26061">
        <property type="entry name" value="DUF8021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042967843" description="DUF8021 domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8021" evidence="3">
        <location>
            <begin position="151"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4038871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="278" mass="29738" checksum="2F52AE70319B0B39" modified="2024-10-02" version="1">MHTLSLLALGAFGPLMASAAECTREFLKTSAESLVAAQKAGDPSLLKPVSDALVYNENFAAATFKSGILATPLKIDHSRHSLDTTQCATYTELISATGSKPYVLGVQMNFADNAVSKMDTLITTTGDWLFNATGTLNWASKENWGTIPEDKRDSRAVIQAAADAYCDIFSNKSVVVPWGYPCARLEGGTYTGNGGPNDKCDVGIPSGVALVDRHYVIDETVGAVSVFLSFSGIPDSHEFRVENGKLRFVHTLTVMSARGNGKSNGRRKLRGVMSPPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SR41</accession>
    <name>A0AAN6SR41_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein YOP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_16914</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854411">
        <property type="protein sequence ID" value="KAK4039066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SR41"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004345">
        <property type="entry name" value="TB2_DP1_HVA22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300">
        <property type="entry name" value="HVA22-LIKE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300:SF177">
        <property type="entry name" value="PROTEIN YOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03134">
        <property type="entry name" value="TB2_DP1_HVA22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="266"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="278"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="294"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="314"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4039066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="375" mass="39811" checksum="ED4D6A2C3E7906A9" modified="2024-10-02" version="1">MFDVFAKLLSSIASFLFPLFASYKALKTADPAQLTPWLMYWVVLACALLVESWTDWFLVWIPFYAYIRLLFLLYLVLPQTQGARLIYEEYIHPRLEENETAIEEFIASAHDRLRSAGVAYLNRAIEMLKTNVLGMAPSPEPPAAAEPHTPQSYTQSLLARFTLPSPRWNTATAQGQTQTGGGSGGLTADFFNLLTTAVSAAASATTTTTTTTTRDPSSSTWTGAGAASIIPDSIRAAGAAARVAFIQAQRERLRVVLSALDREEEAAARQTQTQQTQGLGGDDNGGSGDRKRGSSVGEQSAASSSSGGGGLSKSRSEGDFEKLDAPSGGEEGEGETGGVRRRGGGLEAPAGRSGGWMPWGWGGGGEAGRSSGMER</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SRM0</accession>
    <name>A0AAN6SRM0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_16310</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854393">
        <property type="protein sequence ID" value="KAK4039755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SRM0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF155">
        <property type="entry name" value="EFFLUX PUMP AFOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="321"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="381"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="415"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="449"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="525"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="57"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4039755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="575" mass="61119" checksum="9B03AD62BA0390F8" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SRN5</accession>
    <name>A0AAN6SRN5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Beta-mannosidase B</fullName>
            <ecNumber evidence="3">3.2.1.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Mannanase B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">C8A01DRAFT_47021</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides.</text>
            <dbReference type="EC" id="3.2.1.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; N-glycan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the glycosyl hydrolase 2 family. Beta-mannosidase B subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.25" evidence="3"/>
    <dbReference type="EMBL" id="MU854398">
        <property type="protein sequence ID" value="KAK4039533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SRN5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004567">
        <property type="term" value="F:beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000118">
        <property type="entry name" value="Beta-mannosidase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000050">
        <property type="entry name" value="Beta-mannosidase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054593">
        <property type="entry name" value="Beta-mannosidase-like_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050887">
        <property type="entry name" value="Beta-mannosidase_GH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Ig-like_GH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041447">
        <property type="entry name" value="Mannosidase_ig"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43730">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43730:SF1">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22666">
        <property type="entry name" value="Glyco_hydro_2_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17786">
        <property type="entry name" value="Mannosidase_ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="beta-Galactosidase/glucuronidase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-mannosidase-like galactose-binding" evidence="13">
        <location>
            <begin position="13"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich" evidence="11">
        <location>
            <begin position="237"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="Mannosidase Ig/CBM-like" evidence="12">
        <location>
            <begin position="709"/>
            <end position="800"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF22666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK4039533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="871" mass="99530" checksum="88B0CEF683EE5825" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SRQ4</accession>
    <name>A0AAN6SRQ4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_15968</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854384">
        <property type="protein sequence ID" value="KAK4040132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SRQ4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="525"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="238"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="371"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="533"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4040132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="612" mass="66571" checksum="D41EE7823D6B2E2E" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SSB5</accession>
    <name>A0AAN6SSB5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ATP-NAD kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_35811</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854382">
        <property type="protein sequence ID" value="KAK4040208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SSB5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10330:FF:000033">
        <property type="entry name" value="NADH kinase, variant 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.30:FF:000009">
        <property type="entry name" value="Poly(P)/ATP NAD kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00361">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275:SF26">
        <property type="entry name" value="NADH KINASE POS5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20143">
        <property type="entry name" value="NAD_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbamoyl phosphate synthase ATP-binding" evidence="9">
        <location>
            <begin position="444"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="271"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4040208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="489" mass="52556" checksum="A535B0CA7AC3CA6C" modified="2024-10-02" version="1">MALNSSTMAALGRRCWGLGGRGAAGEGRLFSVSAAHRQILDAAALPDRTVPHYQQTKTSSLLSLHWPQPPRNVLLMPKLHAPRVTVKAIEFAKHIYNNYPGLNLVFESHIAKNIHETLPFPIYTTDPSDAPALFAKKIDLVTTMGGDGTILRAASLFSMHNSVPPILSFSMGTLGFLGEWKFSEYKRAWRECYMSGCSVAIEDLGDPHTRAALAGAQPGDKSDFAPLSGWDSVRGNGQCMGLSRTSKILLRNRLRVGIYDSEGRNINEQLLPTSAAEPDLGPPNRSSGSSSSSSSSSTSPTITTSPPYLHAINEVSIDRGSHPHLAIIDIYVNSHFLTEAVADGILISTPTGSTAYSLSAGGSIVHPLVKSLLITPISPRSLSFRPLVLPLHTKVVLKLSKRNRGRELPVSIDGKRRVGVTIGMEVRVEGERLEKGVDGWRGGVPCVIRASSTRGGGGEGIAEDDDSWVGGLNGLLKFNYPFGEPVEEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SSH5</accession>
    <name>A0AAN6SSH5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">4-hydroxybenzoate polyprenyltransferase, mitochondrial</fullName>
            <shortName evidence="11">4-HB polyprenyltransferase</shortName>
            <ecNumber evidence="11">2.5.1.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Para-hydroxybenzoate--polyprenyltransferase</fullName>
            <shortName evidence="11">PHB:PPT</shortName>
            <shortName evidence="11">PHB:polyprenyltransferase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">C8A01DRAFT_35517</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>an all-trans-polyprenyl diphosphate + 4-hydroxybenzoate = a 4-hydroxy-3-(all-trans-polyprenyl)benzoate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:44504"/>
            <dbReference type="Rhea" id="RHEA-COMP:9514"/>
            <dbReference type="Rhea" id="RHEA-COMP:9564"/>
            <dbReference type="ChEBI" id="CHEBI:17879"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58914"/>
            <dbReference type="ChEBI" id="CHEBI:78396"/>
            <dbReference type="EC" id="2.5.1.39"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="11">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis; terpenoid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Mitochondrion inner membrane</location>
            <topology evidence="2 11">Multi-pass membrane protein</topology>
            <orientation evidence="2 11">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the UbiA prenyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.39" evidence="11"/>
    <dbReference type="EMBL" id="MU854376">
        <property type="protein sequence ID" value="KAK4040476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SSH5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008412">
        <property type="term" value="F:4-hydroxybenzoate polyprenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13959">
        <property type="entry name" value="PT_UbiA_COQ2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1780:FF:000001">
        <property type="entry name" value="4-hydroxybenzoate octaprenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.140:FF:000003">
        <property type="entry name" value="4-hydroxybenzoate polyprenyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1780">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01635">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006370">
        <property type="entry name" value="HB_polyprenyltransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039653">
        <property type="entry name" value="Prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030470">
        <property type="entry name" value="UbiA_prenylTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01474">
        <property type="entry name" value="ubiA_proteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048:SF28">
        <property type="entry name" value="4-HYDROXYBENZOATE POLYPRENYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048">
        <property type="entry name" value="PRENYLTRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00943">
        <property type="entry name" value="UBIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="314"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="338"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="367"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="18"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00052313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00058997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK4040476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="402" mass="43261" checksum="CC878AC09083DDAD" modified="2024-10-02" version="1">MSGCRILPRLPLRRAFSQTANSHKPWRPRLSTRTSQGLSAPRRLALETYTGPSPRSLIAYHITTKLLSTATATPSAPAPQAYTPPQTGLLSVLPRSWVPYAELIRLDKPTGSYYLYFPCIFSTLLAAPLALPMAPPLTVLGTSLLFLAGAVVMRGAGCTINDLWDRNLDPHVARTRLRPIARGAVTPFRAVVFTGAQLLAGLAILLQFPLSCFFYATPSLLLVATYPLAKRVTYYPQFVLGLTFSWGAIMGFPALGVDLLHNGTAQAAAALLYTSNIAWTVLYDMIYAHMDIKDDAKAGIKSIALKHDKETKQVLTGLALTQVALLAGAGIATGAGPAFFVGSCGGALVTLGIMIKRVNLKSVKDCWWWFVNGCWITGGVITAGLTADYLVQYSGRDGEESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SSR3</accession>
    <name>A0AAN6SSR3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_35099</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854367">
        <property type="protein sequence ID" value="KAK4040925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SSR3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="200"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4040925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="381" mass="41890" checksum="E518CD1E4F5335A3" modified="2024-10-02" version="1">MGTEDSTAEPRSYPENRPPAYPDPRPEPDVESDGDSSDEEAWADEQVEGDDEEEDNGGDGGDGKGGEEENDDEGREDGEDGEGGDEDDELWDSDSGSDSDDEDEEDEQETSNTPRPAGNRPLTDKQISDNEEMERLKKELIRRSEAIRPPPPEPRPLGSPHPVNPSFPIITVNRTHRANQYHGVSSVPQEPNRVHGPNTAHGHNPSHHAPPANPIHGGNHRHGPNPIHTTRPVPIIHQAPRAPPTPSIPPNRPVFLHIHDGLYRLLSADEAEAATIHHPTLHRFLFSQAGDEPQFQSQSATIHYAHHSHNDIPTHDGIPTHAHGPTLRQVLEAQAWHKLTVQRMGYCAGCAWCLPWGGGGSRPHRNARPGDGPWGHRGYGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SSR6</accession>
    <name>A0AAN6SSR6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">diacylglycerol cholinephosphotransferase</fullName>
            <ecNumber evidence="21">2.7.8.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="23">Gamma-coat protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="30" type="ORF">C8A01DRAFT_46018</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="31" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="31">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>CDP-N,N-dimethylethanolamine + a 1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33775"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:64572"/>
            <dbReference type="ChEBI" id="CHEBI:65117"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:33776"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="20">Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphatidylcholine from phosphocholine: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasmic vesicle</location>
            <location evidence="4">COPI-coated vesicle membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
            <orientation evidence="4">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 24">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the COPG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="30">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.2" evidence="21"/>
    <dbReference type="EMBL" id="MU854371">
        <property type="protein sequence ID" value="KAK4040731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004142">
        <property type="term" value="F:diacylglycerol cholinephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000046">
        <property type="entry name" value="Coatomer subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000071">
        <property type="entry name" value="Coatomer subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1480:FF:000001">
        <property type="entry name" value="Coatomer subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000008">
        <property type="entry name" value="Coatomer subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1760:FF:000012">
        <property type="entry name" value="sn-1,2-diacylglycerol cholinephosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1480">
        <property type="entry name" value="Coatomer, gamma subunit, appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009028">
        <property type="entry name" value="Coatomer/calthrin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032154">
        <property type="entry name" value="Coatomer_g_Cpla"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017106">
        <property type="entry name" value="Coatomer_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013040">
        <property type="entry name" value="Coatomer_gsu_app_Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037067">
        <property type="entry name" value="Coatomer_gsu_app_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10261">
        <property type="entry name" value="COATOMER SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10261:SF0">
        <property type="entry name" value="COATOMER SUBUNIT GAMMA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16381">
        <property type="entry name" value="Coatomer_g_Cpla"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08752">
        <property type="entry name" value="COP-gamma_platf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55711">
        <property type="entry name" value="Subdomain of clathrin and coatomer appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="18" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="13" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="16" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="17 26" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-0653">Protein transport</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0677">Repeat</keyword>
    <keyword evidence="10 24" id="KW-0808">Transferase</keyword>
    <keyword evidence="11 26" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15 26" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="970"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="1185"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="1218"/>
            <end position="1239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="1246"/>
            <end position="1266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="1286"/>
            <end position="1310"/>
        </location>
    </feature>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="27">
        <location>
            <begin position="21"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer gamma subunit appendage Ig-like subdomain" evidence="28">
        <location>
            <begin position="651"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer subunit gamma C-terminal" evidence="29">
        <location>
            <begin position="802"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="607"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="25">
        <location>
            <begin position="607"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="25">
        <location>
            <begin position="635"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00025536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00037890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00038987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00051857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00081297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="Pfam" id="PF08752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="Pfam" id="PF16381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="EMBL" id="KAK4040731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1348" mass="149062" checksum="6771BC575B00D895" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6ST46</accession>
    <name>A0AAN6ST46_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Autophagy-related protein 101</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_45701</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATG101 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854364">
        <property type="protein sequence ID" value="KAK4041063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6ST46"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990316">
        <property type="term" value="C:Atg1/ULK1 kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012445">
        <property type="entry name" value="ATG101"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13292">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13292:SF0">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07855">
        <property type="entry name" value="ATG101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0072">Autophagy</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="79"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="79"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="91"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="111"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4041063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="251" mass="26812" checksum="FBC24287318FBC18" modified="2024-10-02" version="1">MDQRAAPEFILEAFADPNSVRDVVRGILHTIFFLRFFSTVHPQTRDVLGLELAYVPEAEIETLVDQRVAALVRQLEAERHQPHTLPDHNRGGGGMGLGLLGGGTPPSNSSTGGGGGGGRGQITIQFLEKRRRKTWYAMRGDDEVCWESWTVKVTVADPRTEGERAKVRRASETTLHNTIMKAVTLANAHKDHIPPITVSDSNPFPYQIHVGGSGSNPSGGQQKEPAVAAGAGAGAGAAAAATGWATRMGIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6ST71</accession>
    <name>A0AAN6ST71_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Golgi to ER traffic protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_44648</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854343">
        <property type="protein sequence ID" value="KAK4042259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6ST71"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028143">
        <property type="entry name" value="Get2/sif1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28263">
        <property type="entry name" value="GOLGI TO ER TRAFFIC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28263:SF1">
        <property type="entry name" value="GOLGI TO ER TRAFFIC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08690">
        <property type="entry name" value="GET2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="292"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="330"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4042259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="350" mass="36458" checksum="52AFC407B2E24570" modified="2024-10-02" version="1">MTELSPDEDAASARAAEQARLRKARREAKIKAGAENRLNKITGLGGGVPRDPAPAPAPAPAPSATATPSAPASTAAAAAAQHADPEEVDISEHFYQPQTTPRVAPPSNGPGPGGNISDAQLRQLMLGLDQPGTTTPPPMPGMPPGMEDDPMMRMMMQMLGGNASSNPFGGMPGMPGMGGMRFPPPTQGGSGAPQQTAAALFPNKSASLWRLLHTLVALALGLYIALYTPFTGTKLSRDRAAAAAAGSAEERLHLAAQQPGREVTQNFFWAFATAEAVLLGTRYFMERGRSRLQSATMGGSGILGMVVGFLPAGVRSKVEMAMRYGEVFGTVRQDVLVCVFVLGVAGWVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6ST86</accession>
    <name>A0AAN6ST86_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_34802</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854362">
        <property type="protein sequence ID" value="KAK4041183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6ST86"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025829">
        <property type="entry name" value="Zn_knuckle_CX2CX3GHX4C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13696">
        <property type="entry name" value="zf-CCHC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="6">
        <location>
            <begin position="289"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="122"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="350"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="412"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="475"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="767"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="167"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="198"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="238"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="352"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="412"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="482"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="767"/>
            <end position="783"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4041183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="791" mass="87336" checksum="BE6CCE727180FD9E" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6STL9</accession>
    <name>A0AAN6STL9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_34106</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854350">
        <property type="protein sequence ID" value="KAK4041855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6STL9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37852:SF1">
        <property type="entry name" value="HIG1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37852">
        <property type="entry name" value="YALI0B21208P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4041855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="208" mass="23249" checksum="7FC50A8396969886" modified="2024-10-02" version="1">MATADDRTTSRIRRELPPPPSPAEIDALYRNARLSLPAPLRLPMASSLSFFAGFTLGTAYGGKTAGLQFRAEHAHKLPTSSTGWYLYHKSKNYHMAYGGIREGFRMGFKVSFWTTAMFAVEQMFDSYRGTADIFNTVTSCVSVAGGFSLWNRFSLPMTARTTKAALVAGFVYGGLQDVMGMVRGRPIRYVDWIRQRLGSPRQEQPRNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SUC0</accession>
    <name>A0AAN6SUC0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Dfp1/Him1, central region-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_14021</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854342">
        <property type="protein sequence ID" value="KAK4042383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SUC0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031431">
        <property type="term" value="C:Dbf4-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010571">
        <property type="term" value="P:positive regulation of nuclear cell cycle DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901987">
        <property type="term" value="P:regulation of cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3410:FF:000001">
        <property type="entry name" value="Protein DBF4 homolog A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3410">
        <property type="entry name" value="DBF zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055116">
        <property type="entry name" value="DBF4_BRCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013939">
        <property type="entry name" value="Regulatory_Dfp1/Him1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051590">
        <property type="entry name" value="Replication_Regulatory_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006572">
        <property type="entry name" value="Znf_DBF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038545">
        <property type="entry name" value="Znf_DBF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15375">
        <property type="entry name" value="ACTIVATOR OF S-PHASE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15375:SF26">
        <property type="entry name" value="PROTEIN CHIFFON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22437">
        <property type="entry name" value="DBF4_BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08630">
        <property type="entry name" value="Dfp1_Him1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07535">
        <property type="entry name" value="zf-DBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00586">
        <property type="entry name" value="ZnF_DBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51265">
        <property type="entry name" value="ZF_DBF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DBF4-type" evidence="6">
        <location>
            <begin position="587"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="159"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="521"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="163"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="177"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="219"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="529"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="539"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="555"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4042383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="639" mass="71269" checksum="9792A44D89152FF8" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SUP5</accession>
    <name>A0AAN6SUP5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Importin-95</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Karyopherin-95</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_32124</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the importin beta family. Importin beta-1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854324">
        <property type="protein sequence ID" value="KAK4043804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SUP5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000027">
        <property type="entry name" value="Importin subunit beta-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058584">
        <property type="entry name" value="IMB1_TNPO1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25574">
        <property type="entry name" value="TPR_IMB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="9">
        <location>
            <begin position="25"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00079884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00083566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4043804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="877" mass="95977" checksum="12A018BB08687DF1" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SUP6</accession>
    <name>A0AAN6SUP6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Mitochondrial CCA tRNA nucleotidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_44159</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the TTI2 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854335">
        <property type="protein sequence ID" value="KAK4042801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SUP6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110078">
        <property type="term" value="C:TTT Hsp90 cochaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052929">
        <property type="term" value="F:ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052927">
        <property type="term" value="F:CC tRNA cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001680">
        <property type="term" value="P:tRNA 3'-terminal CCA addition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05398">
        <property type="entry name" value="NT_ClassII-CCAase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3090.10">
        <property type="entry name" value="cca-adding enzyme, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002646">
        <property type="entry name" value="PolA_pol_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032828">
        <property type="entry name" value="PolyA_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018870">
        <property type="entry name" value="Tti2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13734:SF5">
        <property type="entry name" value="CCA TRNA NUCLEOTIDYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13734">
        <property type="entry name" value="TRNA-NUCLEOTIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01743">
        <property type="entry name" value="PolyA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12627">
        <property type="entry name" value="PolyA_pol_RNAbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10521">
        <property type="entry name" value="Tti2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81891">
        <property type="entry name" value="Poly A polymerase C-terminal region-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly A polymerase head" evidence="7">
        <location>
            <begin position="53"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding" evidence="8">
        <location>
            <begin position="225"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4042801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1029" mass="112781" checksum="760CBC0A821E82AA" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SVF3</accession>
    <name>A0AAN6SVF3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Selenoprotein O</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">C8A01DRAFT_12902</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SELO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854326">
        <property type="protein sequence ID" value="KAK4043581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SVF3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070733">
        <property type="term" value="F:AMPylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00692">
        <property type="entry name" value="SelO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003846">
        <property type="entry name" value="SelO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32057">
        <property type="entry name" value="PROTEIN ADENYLYLTRANSFERASE SELO, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32057:SF14">
        <property type="entry name" value="PROTEIN ADENYLYLTRANSFERASE SELO, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02696">
        <property type="entry name" value="SelO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="300"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="542"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="588"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="589"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK4043581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="710" mass="78675" checksum="9D2AAF5F7C3624ED" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SVM1</accession>
    <name>A0AAN6SVM1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transferase family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_12663</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854323">
        <property type="protein sequence ID" value="KAK4043910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SVM1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051283">
        <property type="entry name" value="Sec_Metabolite_Acyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054710">
        <property type="entry name" value="Tri101-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31896">
        <property type="entry name" value="FAMILY REGULATORY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G14730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31896:SF64">
        <property type="entry name" value="TRICHOTHECENE 3-O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22664">
        <property type="entry name" value="TRI-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Trichothecene 3-O-acetyltransferase-like N-terminal" evidence="2">
        <location>
            <begin position="20"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4043910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="460" mass="50553" checksum="7FBCE757F1968012" modified="2024-10-02" version="1">MDGFDYMQDVVGQLPFLKTYSHLLVAFPLPDDDSSREEAKQRLLEASLRLTEAFPWLAAKVVQRSNGPGRSDSLHLEPCELWSSPNSIIRFTDCSNAMPCYKELVKARGPASMLPGDVLAPRKAFPESYQETEQDPAPVIALQANFVRGGLLLDCAAQHNFIDMSGIAQCFSLLATALRGEPFPCDAIAQGNMDRRNLVHLLQGNEAVLDHAQFLRPGPDTLPPPPAEPESPFSWRYFRFSPAKLAALKSMAAPSATGTTASGSEYVSTNDALTAFCWQRVIATRLARRRTPEAVAKFCRAVDARRAMGVPAGYMGDLVTIATSTMGFRELAEAPLADVALRLRRDLATVNNRDYVRSFATWIARTADKTVIAYGGKFNPDTDIGSSSWAQIGLASVAFGPLLGRPSLIRRPDFVPLKSDIYFMPQTERGNIDALVCFNQADLDGLMRDQMWTAYADYIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SVP4</accession>
    <name>A0AAN6SVP4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="16">BCS1 N terminal-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">C8A01DRAFT_43241</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family. BCS1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854323">
        <property type="protein sequence ID" value="KAK4043866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SVP4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057495">
        <property type="entry name" value="AAA_lid_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014851">
        <property type="entry name" value="BCS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050747">
        <property type="entry name" value="Mitochondrial_chaperone_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23070">
        <property type="entry name" value="BCS1 AAA-TYPE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25426">
        <property type="entry name" value="AAA_lid_BCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08740">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01024">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="BCS1 N-terminal" evidence="15">
        <location>
            <begin position="56"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="288"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="357"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="526"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="365"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="375"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="526"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="536"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="581"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="619"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="631"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK4043866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="664" mass="75093" checksum="4BF8774CB5D721A0" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SWA2</accession>
    <name>A0AAN6SWA2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_42874</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854319">
        <property type="protein sequence ID" value="KAK4044451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SWA2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4044451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="254" mass="28759" checksum="C9D4ADE523C851AA" modified="2024-10-02" version="1">MGNKHAPGATQADMTRPSIATLPYEIQVAIFEAAMDPQIFFVDITNNFRTFTRPAAKALGLACLLSREVYIKSKTLHMFGERFHWVDPERDIFYLRKDDPVPRAQRPTDQESNLPSGEWFNSSAVRNVAVDLLYLGDHPRHDPVIRLWTLFPDMRAIHVFVPKGPPQTPVLRATPETLVLSAIPSNQIVAAPGHDRELWLAVRYQVKKVCARILDTENGWRGRFQPEVAGHLTSLWVTQTQSQTPPEDADGEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P4J3</accession>
    <name>A0AAN6P4J3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD-dependent urate hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_42015</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854770">
        <property type="protein sequence ID" value="KAK4031539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P4J3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF316">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="9"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4031539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="432" mass="47403" checksum="11887865CCF8A443" modified="2024-10-02" version="1">MTLTAPPSEIAIIGGGLAGLTLALALHRVQIPCTVYEARSEHHNPGGGLMLSPNALRPLDRLGAYERLRDKALNFDKLYFQNDRDGTTDIYYFGSRAIYGYEAMRIMRRELLGELLAMVRERGIPVHFDSALATVVDSEENGEKVEFTFTDSRTASASLLVGADGIHSAVRSSLFPDAKPQYAGILGINCVVERSRLRIPEGYGLPAIAMGKPGGFLLVPQRPDGSELYVGAQRRFPELDEAGWRALRQDRQRLYDMIHEQQADWPDVVQSALEAMTVDRMGFWAFHGLPPLASWLSDRSGRVILVGDAAHAIPPTVGQGANQAVEDVCALAALLARLSPEVPLDAAARAWQGYRQARVQRILDLTAQMNAKRLPEAEKAKLPPGAIWTDAGLTRGEGGELGWLYNVDLEEEVEKWVRELRLKAGVALSNGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P4Z7</accession>
    <name>A0AAN6P4Z7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_41702</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the RNase T2 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854688">
        <property type="protein sequence ID" value="KAK4031864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P4Z7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033897">
        <property type="term" value="F:ribonuclease T2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.730.10">
        <property type="entry name" value="Ribonuclease T2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050432">
        <property type="entry name" value="FAD-linked_Oxidoreductases_BP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001568">
        <property type="entry name" value="RNase_T2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036430">
        <property type="entry name" value="RNase_T2-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878:SF91">
        <property type="entry name" value="FAD BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G12070)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878">
        <property type="entry name" value="GULONOLACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00445">
        <property type="entry name" value="Ribonuclease_T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55895">
        <property type="entry name" value="Ribonuclease Rh-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042912938" description="FAD-binding PCMH-type domain-containing protein" evidence="6">
        <location>
            <begin position="20"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="7">
        <location>
            <begin position="734"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="275"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="426"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4031864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1248" mass="135828" checksum="611D69296C9B64F5" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P5G0</accession>
    <name>A0AAN6P5G0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Dynamin family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_51023</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854647">
        <property type="protein sequence ID" value="KAK4032118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P5G0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001425">
        <property type="entry name" value="Dynamin GTPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
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        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF149">
        <property type="entry name" value="GTPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11890)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="44"/>
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        </location>
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        </location>
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        </location>
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            <begin position="431"/>
            <end position="455"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4032118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="756" mass="85205" checksum="8E9B10392067AA47" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P6N9</accession>
    <name>A0AAN6P6N9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_40811</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <end position="199"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="26"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4032748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="223" mass="24221" checksum="973162F76014F9DD" modified="2024-10-02" version="1">MTNRKYNSKEQRRYRDKQTATLARAANQSLAQTTSAGENASQSVPSPTSKPSGQLAGENSKAPKPQVAAMPTPFSTPTTLEEAAAEVEFLRLIAHAQQNRIELLEEKVKVSEELHKKTADTINALMNLSLETVQTMGNMLANNHNDATNNPNGREPADADALSEIQSLQFVIQEQAARIERLEQKQVQTTELLDALRTLALETAQRAGNEDAVAAFGLAVGDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAN6P759_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="ORF">C8A01DRAFT_40556</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
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            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854559">
        <property type="protein sequence ID" value="KAK4033001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P759"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:RNA endonuclease activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Microbial ribonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4033001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="143" mass="16544" checksum="7882635A730159A9" modified="2024-10-02" version="1">MAFIHHRAISSLHYSLPNLSPTNPVRRVRASEVRAQAAAIPAAIKKRPYYPHAFGNHEQLPFEQNSQPLIEHPLMPDGEMPWQEGQGRRAGPARIVVNEWDRSTPEVAYHDPTLPRARDRVTGRWRARPFSKGVYREREEFNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P761</accession>
    <name>A0AAN6P761_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_50404</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854564">
        <property type="protein sequence ID" value="KAK4032919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P761"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4032919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="255" mass="28365" checksum="8FE732E46C82F564" modified="2024-10-02" version="1">MASTGSMESTTPSPAAAPMDTNSPVSPLLGLDPHGRYWPTLDRASDPQPRKSCLKSAKSAAAAATGRQRLSVRFADDTHCLVLGTVVPPHDSSRPRDQWISELTDEIMADIETVDLKRVDRTKWSRRGARIAHRLLHLADFDPWNPEDLAFRLFFRRAQRHTLCNKRDSPISSRRDRGDHPTLWSLLWPPDPDGVSTCSRQRPDRHRPATFPPPPGQGRRPSSTRPLVGTGTGGVKPVVCSWARRGYQPPVSRPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P8B9</accession>
    <name>A0AAN6P8B9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_19461</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854519">
        <property type="protein sequence ID" value="KAK4033616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P8B9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4033616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="240" mass="26911" checksum="C8004549284C3E1B" modified="2024-10-02" version="1">MDTVINAWDGILYRSFPQHTRHRGGDFYSLPLRRHAGAWGDGWGRSIVVQLLTPDWDFKPGVGHGGPPPPAERTDVAWVELAAPSKARSRSAWRDLMQIAVDRLAEANTEGRLLLILVAGFRWMPFMWDPVEPRLPGRGPLVMKGDGEDERWPVDPRVHMVLREGEVEPISRLTFDPLDAYTLDYWTKDESGAVLNLKNLLWLEKLLAAARPGALAVTEESDRKDAHGCETSSDSNLPES</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P8Z9</accession>
    <name>A0AAN6P8Z9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ethanolamine-phosphate cytidylyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_49529</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="8">Phospholipid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytidylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854501">
        <property type="protein sequence ID" value="KAK4033949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P8Z9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004306">
        <property type="term" value="F:ethanolamine-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02173">
        <property type="entry name" value="ECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044608">
        <property type="entry name" value="Ect1/PCYT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45780">
        <property type="entry name" value="ETHANOLAMINE-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45780:SF2">
        <property type="entry name" value="ETHANOLAMINE-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="6" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="255"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4033949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="283" mass="32143" checksum="4E8F4E2A0982CA37" modified="2024-10-02" version="1">MLLCTRGHFIRSLEKTLAGLEGAGTVDERKAEGEAMTERVRLYATDETAKAPGAEVWFWGVESGFRRLFEGVRPRPGQRVVYVDGGFDLFSSGHIQFLRLVTEAEEELARKEGWYEEQAVNERRGKGADYGPVFVVAGVHDDGVINKWKGVNYPIMNIFERGLCVLQCRYVNAVVFGAPFTPTKSYLTSLPWGTPDAVYHGPTSFMPFTDDVYTEPKQMGIYREIGHHEFEDVNAGTIVQRIMKSRDLYEARQKAKGMKADLEAAHRQRELLEEEQRRKEAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P9G9</accession>
    <name>A0AAN6P9G9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Transmembrane amino acid transporter protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">C8A01DRAFT_39335</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854490">
        <property type="protein sequence ID" value="KAK4034204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P9G9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF458">
        <property type="entry name" value="SODIUM-COUPLED NEUTRAL AMINO ACID TRANSPORTER 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="236"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="280"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="356"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="392"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="475"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="498"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="530"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="10">
        <location>
            <begin position="161"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="68"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK4034204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="565" mass="61013" checksum="C49A56FBD4F47330" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P9H3</accession>
    <name>A0AAN6P9H3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carbonic anhydrase</fullName>
            <ecNumber evidence="5">4.2.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Carbonate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_39289</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Reversible hydration of carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>hydrogencarbonate + H(+) = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the beta-class carbonic anhydrase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="5"/>
    <dbReference type="EMBL" id="MU854488">
        <property type="protein sequence ID" value="KAK4034231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P9H3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03379">
        <property type="entry name" value="beta_CA_cladeD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1050.10">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001765">
        <property type="entry name" value="Carbonic_anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036874">
        <property type="entry name" value="Carbonic_anhydrase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43175:SF3">
        <property type="entry name" value="CARBON DISULFIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43175">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00484">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00947">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53056">
        <property type="entry name" value="beta-carbonic anhydrase, cab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR601765-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4034231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="170" mass="18293" checksum="95694997C263FB7E" modified="2024-10-02" version="1">MSAIQTNVEAASASYAASFTKGHLALPPAKKYLVLTCMDARIDPAQAFGIELGDAHVIRNAGASAVDALRSVVISQQLLGTTEVVLVKHTGCGMLTFKNEDAYQVVGKQLGQAALDELTEKKLDFLPFPELEKAVVEDVEFLRASKLVAESVVISGWVYEVETGKTRRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PAA5</accession>
    <name>A0AAN6PAA5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_38924</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854472">
        <property type="protein sequence ID" value="KAK4034615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PAA5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4034615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="253" mass="28130" checksum="44C0BEE5569F9ECD" modified="2024-10-02" version="1">MPENRGLGASSDDDRDYDEGRTLSNLGYPAYNHPAVLPEAVWNAMEGSDGEQSEELKSALLSLPRNKKRSIDHLVNTWLNHKHDQCYALDATEFRAQYERWWATPRDKVTAGLTSLILRVYACSLHFTAEDGVTELDGTDVRELANRVHTAAEKFSDSILPGEGGLAQVQQLFLTAIWLESSAKRIQSRHALGKTIMAAYELGILSVPSFEDDLYEADVLKVFTNPTCLKAYRNPSGRKEDVCGLFCAYGIAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PAU5</accession>
    <name>A0AAN6PAU5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 17">Pyruvate kinase</fullName>
            <ecNumber evidence="6 17">2.7.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">C8A01DRAFT_20079</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16 17">
            <text>pyruvate + ATP = phosphoenolpyruvate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18157"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.40"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the pyruvate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.40" evidence="6 17"/>
    <dbReference type="EMBL" id="MU854564">
        <property type="protein sequence ID" value="KAK4032916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PAU5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004743">
        <property type="term" value="F:pyruvate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.33.10:FF:000001">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.60:FF:000001">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1380.20:FF:000001">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.10">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.20">
        <property type="entry name" value="Pyruvate kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001697">
        <property type="entry name" value="Pyr_Knase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018209">
        <property type="entry name" value="Pyrv_Knase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015793">
        <property type="entry name" value="Pyrv_Knase_brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015795">
        <property type="entry name" value="Pyrv_Knase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036918">
        <property type="entry name" value="Pyrv_Knase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015806">
        <property type="entry name" value="Pyrv_Knase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01064">
        <property type="entry name" value="pyruv_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11817">
        <property type="entry name" value="PYRUVATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00224">
        <property type="entry name" value="PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02887">
        <property type="entry name" value="PK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01050">
        <property type="entry name" value="PYRUVTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52935">
        <property type="entry name" value="PK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00110">
        <property type="entry name" value="PYRUVATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14 17" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="11 17 21" id="KW-0418">Kinase</keyword>
    <keyword evidence="13 17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15 21" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate kinase barrel" evidence="19">
        <location>
            <begin position="25"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Pyruvate kinase C-terminal" evidence="20">
        <location>
            <begin position="279"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="459"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="627"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="855"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="514"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="629"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="675"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="864"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="898"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="921"/>
            <end position="936"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF02887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAK4032916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="960" mass="104939" checksum="859C389D44F7D1E6" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PAW2</accession>
    <name>A0AAN6PAW2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ubiquitin 3 binding protein But2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_50381</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854562">
        <property type="protein sequence ID" value="KAK4032946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PAW2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025649">
        <property type="entry name" value="DUF4360"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38847">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR38847:SF1">
        <property type="entry name" value="PSEUDOURIDINE SYNTHASE RSUA_RLUA-LIKE DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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        <property type="entry name" value="DUF4360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042834373" description="Ubiquitin 3 binding protein But2 C-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4032946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="212" mass="21930" checksum="904AC2E71492FB05" modified="2024-10-02" version="1">MFLTSSQTLSLLLALTPSAISASILPRLNNVTVTSVSAHGLGCPEGTLSSNINPDKTTVTFGFDEFQAYLGPGYSVIEKSQTCTITLSLSYPPGSTFKITDAVYHGSARLDAGMSANIRSSYRITSDEAGGSAAQTQASAAGELLGVYTRTDTIPSSSRIGSACGRGEAVLQITTRIAVTSSSASVSGNVDDEPVFSLGVQQLGLEWSACET</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PB26</accession>
    <name>A0AAN6PB26_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_40832</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854581">
        <property type="protein sequence ID" value="KAK4032717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PB26"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF5">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NACHT" evidence="2">
        <location>
            <begin position="50"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4032717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="323" mass="36560" checksum="C6F3EDAE2D9FCB6B" modified="2024-10-02" version="1">MSLWFPLMKDREEMIHDPHNQTFDWIFRDPAETGKPWDDIGKFLQTASSGTYWISGKAGSGKSTLMKYISNNATTRRLLLRWAGQNELVMVSFYFYHGGSELQKSEVGVLRSLLYQILATRPGLIQLAFPERFRALCIAGGQRETFEPSPTELRRAFNAVVQKCSDVNFFLAVDGLDEYNGADADMSLLVSMVRDLTQHSKVKGLLSSRPWAVFQQSFAGCPQLRLHDFTRPDIARFVSAKVGQHSRVQTMTAKDSQGVDNLMTEIVDASCGVFLWVYLVVLSVLEGLTNYDMVEEIRYPSTTLHKRQDFSCSWKRAPSRTSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PB72</accession>
    <name>A0AAN6PB72_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_39405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854493">
        <property type="protein sequence ID" value="KAK4034147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PB72"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4034147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="226" mass="25262" checksum="D62089CF65EB475A" modified="2024-10-02" version="1">MSGLPKNLSLLVDWFPRAGFLWRRGQGSPRILRSDFRDAVVRRAIAELLGDGGAKIRKRDAQDLVANALAVAAKTITDPEAGIRPEEGIIDFLERAAKFADLSQAIPENIWVELVYQIARARYEYECNTPAAQKKGDEDRLTGLAHAIDDLVDGAGQHWDWTTLELYAYPHLMGEAADYEIDDSDNDDNAAAEDEEMADDEAEKMLPRRMEQLTIKDADGDVEMEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PBB2</accession>
    <name>A0AAN6PBB2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_40706</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854571">
        <property type="protein sequence ID" value="KAK4032837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PBB2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4032837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="166" mass="18952" checksum="9385B68445F00E23" modified="2024-10-02" version="1">MVSDLRADWIYRFSDCPKTFIKKESLKKYQNRYYAKEIEVFNSKLASIVDGNVLSEEEKDIACHLAKVYNSAKGIKGRGKGLYSFFYGLSNPAAYSMNWPPPTAILWGYSGPPLSFNTQDTAYAHYHHYDAYADYSDASSVHGPMPVPYIYKEEHGQDLAFGDRLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PBM0</accession>
    <name>A0AAN6PBM0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_38423</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854455">
        <property type="protein sequence ID" value="KAK4035089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PBM0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049168">
        <property type="entry name" value="Glyco_hydro_134"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21087">
        <property type="entry name" value="Glyco_hydro_134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042911892" evidence="1">
        <location>
            <begin position="18"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4035089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="198" mass="21847" checksum="F3C72AC8CEC3AFE8" modified="2024-10-02" version="1">MQLSNLLAIVVAATAAAVPMNPVSEVTNVSLTKRADRGSYTVSGLGQRKQAILNAGGNTLDIAIAMLETERMSTDYVYGDAKTADAANFGLFKQNWGMLRVCASRAGFVGQSTSQWNNGAKLNWDIYADVASRWDCQNYYGYDKWFAGHRNGASGLSDPYTEDINNYKTAIQWIQSQVDSNSKYKTDDTRFWVNVTPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PC47</accession>
    <name>A0AAN6PC47_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ceramidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_48220</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the alkaline ceramidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854438">
        <property type="protein sequence ID" value="KAK4038163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PC47"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046514">
        <property type="term" value="P:ceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008901">
        <property type="entry name" value="ACER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46187">
        <property type="entry name" value="ALKALINE CERAMIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46187:SF1">
        <property type="entry name" value="ALKALINE PHYTOCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05875">
        <property type="entry name" value="Ceramidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="75"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="151"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR608901-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR608901-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4038163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="251" mass="29109" checksum="F73271BD368C4F19" modified="2024-10-02" version="1">MGHHNIQFAGDASSNNGAWSPPTSRANFCEEDYVISFYLAEFINALTNISYVYLALRAMYPPRPTRSLLRPKYDFMSLSLLTLGIGSFLFHATLRQTLEFVDEFSMLGLTWSMLQASLTARQTPKRARLITVGLAVAYLSFSAFYIWSAKIIYQVFAFTGALFGVLFRGQYMFHLARPAFPEAKRRDWNWRIWKALGICVFGYVLWTVDLEYCAELRAVRQRVGLPWAWLFDQSMQVAREIREEERERKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PCB0</accession>
    <name>A0AAN6PCB0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ZIP zinc transporter-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_48119</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854435">
        <property type="protein sequence ID" value="KAK4038238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PCB0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16950">
        <property type="entry name" value="ZINC TRANSPORTER SLC39A7 HISTIDINE-RICH MEMBRANE PROTEIN KE4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16950:SF16">
        <property type="entry name" value="ZINC TRANSPORTER ZIP13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042832478" evidence="7">
        <location>
            <begin position="27"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="364"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="399"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="201"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="208"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4038238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="420" mass="44144" checksum="C54CE22E9230EF51" modified="2024-10-02" version="1">MALLNPRRARAAALVLVAAFALTAWASTTTTTTTKTDLPSLETLSLAELDAQLQPTNQLLICRQECPIITTLSSHKAAHHARTPSSLTTRLFATLFPSSHPAINALLATLYISGPPNFLLALCPTNIDPASLSVMVAFAVGGLLGDTLFHLLPEIFLGEDEPDRVRMVLVEPNRNLLLGVAVLVGFLVFVGMDKGLRIATGGSGGHSHGHDHGHGSHAVGEGEGRSSAMEEKGEGARWKKEVNPSVKLGGLLNMIADFTHNITDGLAMSASFYASPTIGATTTVAVFFHEIPHEVGDFALLVQSGFSKRQAMGAQFVTAIGALLGTLIGIAVQEFGGGGGGNTDGPEMGMRDGLWGTSLTWGDMLLPFTAGTFLYVGTVAVIPELLETGANKAAELRKTLVQFAAILAGAGIMLYISWHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PCD9</accession>
    <name>A0AAN6PCD9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">High-temperature-induced dauer-formation protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_19613</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854530">
        <property type="protein sequence ID" value="KAK4033437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PCD9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005797">
        <property type="term" value="C:Golgi medial cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000138">
        <property type="term" value="C:Golgi trans cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026705">
        <property type="entry name" value="Hid-1/Ecm30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21575">
        <property type="entry name" value="PROTEIN HID1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21575:SF12">
        <property type="entry name" value="PROTEIN HID1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12722">
        <property type="entry name" value="Hid1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="575"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="861"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="598"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="624"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="647"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="694"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="866"/>
            <end position="884"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4033437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="884" mass="97950" checksum="1DA7E816B1D4EBA8" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PCI3</accession>
    <name>A0AAN6PCI3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_37613</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854429">
        <property type="protein sequence ID" value="KAK4038432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PCI3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4038432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="357" mass="40287" checksum="E0E7D2DEA3ECDFEA" modified="2024-10-02" version="1">MSIDAWATILVTATPTLNSIEDYFGIILQIWRRAGFFDFTLPTETSWGYMVDHFEIVDIELEQVKKDGLCPNLHPWRNDHTNAEMITMNNETITRRIFWYMDGAVPPRRALLDWSLRTGIKWWLMHPSAMRKIKTDTSRNRLGGEDIYKAVQQMVTVRIPMNTEIVLPDGSSTYPREEMPPMEIQYVQCRYPQEKAKLVAKVATGLVKLLPNIGDIQDDPNAAGRVARSAAAATPLATTKGKQERAKKINMTCHKLLTLDAIDHRAFFVLTQVEDPLSNRLGYAKLHHDMVNNRLHAKLPVDKEALKMVMRGLLEVAGEDKLHGQDSPGPKLGSAHVEALAEEHPSGGLAWLYSISP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PD44</accession>
    <name>A0AAN6PD44_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AA1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_37297</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854420">
        <property type="protein sequence ID" value="KAK4038732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PD44"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042875354" description="AA1-like domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4038732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="174" mass="18696" checksum="F247964D1523492C" modified="2024-10-02" version="1">MMLHFILVLAAAAQLAVALPAYKVPLALSRVAAFCVYPEEFVVKNFQIWTPATGNNRSAVINFDYTDDSVMPAIETKCHFNETSANVGAEGLAPRYACDNSLVEFIWQNGTLTLIERACPLETENRPFEAAGVVTPKLACFTSQRNSTVGAGSACSSTPKVMSAGFTSLQPSPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PD75</accession>
    <name>A0AAN6PD75_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Non-ribosomal peptide synthetase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_38176</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854447">
        <property type="protein sequence ID" value="KAK4035330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PD75"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052979">
        <property type="entry name" value="Adenylate-forming_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33927">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33927:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="285"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4035330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="510" mass="56493" checksum="BDA7B84B0D6E3BB3" modified="2024-10-02" version="1">MSGGAKWSHHEQALPAGATVSSTAWDDAEKGLYDSTPTLPVIATPPAAHIDEKRALETVSTADGTVAPPGPSPAPAKKPPKPKPSRWILFQLWFNTYRKFFVFVTVLNLTGIVLAAVGRFEYAENHLGALVLGNLLMAVLMRNELFLRFLYIISIYGLRSWAPVCVKLAVTSILQHVGGIHSGCALSGAAWLVYKIVDIIRYRAVQHSSVIATGIITNAAVIISVLSAFPWIRNNYHNTFERHHRFIGWLGIAATWVFVILGNTYDIKRGEWRHDANSLLSAQELWFAAFMTVFVLIPWVTLREVPVEVELPSPKVAILKFQRGMQQGLLGRISRTSIMEYHAFGIISEGRKSGCHYMICGVQGDFTKDLVANPPKTVWTRELKFAGVGHASAMFKRGIRICTGTGIGAALSTCIQSPNWFLIWIGSDQEKTFGPTITGLIYNNIPPERMILWDSKKRGGRPDSVKLLKEVWDSFGAEVIFITSNMQGNDEMMQGCRVAGMDAFGTLWDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PDJ1</accession>
    <name>A0AAN6PDJ1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA mismatch repair protein HSM3 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_18476</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854466">
        <property type="protein sequence ID" value="KAK4034778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PDJ1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4034778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="383" mass="42209" checksum="ED5FBB94EB2B1EE0" modified="2024-10-02" version="1">METTPITGLDELDKHLDDLLQDASLALNPKLFDDVELQLTETNIPPLIPRFLPRLTALLKQYPQDPAVIVSLTVMLLGPLPFDDVFSIAESDDLVEALDSPAPSANLLVLSILHKATLPRHISFFCMDTNLVFAFIRRWLASPQVEVGQKAGKVLGDLLDIDCPLPPPPPPTRPVDASHADLTLRKAPGHGTLWNLVFNDRRMYTLLLDLIAGRHPDTAGDPHQLSLAQGRVLRILPRLAAINFRAVSHSHMTAPTPVHFTNGNEQCTDGEEQPPPSNPNPPRPGEGLLQYAALRMVQKSDTLMHLSLVDFFETLVSLLRVTEDSTLKTETLRAMLGEATGGDAVLRDALLSLPERTVEVEAEDLRRWLREVMPGETVGLAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PDY9</accession>
    <name>A0AAN6PDY9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sas10 C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_16783</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAS10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854407">
        <property type="protein sequence ID" value="KAK4039197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PDY9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007146">
        <property type="entry name" value="Sas10/Utp3/C1D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018972">
        <property type="entry name" value="Sas10_C_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13237:SF8">
        <property type="entry name" value="SOMETHING ABOUT SILENCING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13237">
        <property type="entry name" value="SOMETHING ABOUT SILENCING PROTEIN 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09368">
        <property type="entry name" value="Sas10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04000">
        <property type="entry name" value="Sas10_Utp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sas10 C-terminal" evidence="7">
        <location>
            <begin position="551"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="318"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="385"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="442"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="467"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="139"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="9"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="111"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="347"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="390"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="467"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="525"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="567"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4039197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="625" mass="69810" checksum="9662AFE48B7ED31E" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PEA2</accession>
    <name>A0AAN6PEA2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HAD-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_17476</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854429">
        <property type="protein sequence ID" value="KAK4038443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PEA2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01427">
        <property type="entry name" value="HAD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43885">
        <property type="entry name" value="HALOACID DEHALOGENASE-LIKE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43885:SF1">
        <property type="entry name" value="SUPERFAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G13290)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13242">
        <property type="entry name" value="Hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4038443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="291" mass="32260" checksum="0FB6D68A21B577E3" modified="2024-10-02" version="1">MRRFYSMMQSASPTWKFAPLQRPLTTKTSPQTRKLEGIVFDVDGTLCEPQTYMFHEMRAALGIPKSQDILEHVYSLPTPEQQHQAMDLIRDIERRAMLQQVAQPGLAELMAYLDARGVRKGICTRNFDTPVNNLLNKFLAGSVFAPIVTRDFRPPKPDPAGILHIARSWGLLRRSTGEAGVPADPREEDERRRRSAAEEEGSRQDGGGGEEEADGAADDLLQTQVGEEVADASGLIMVGDSIDDITAGRRAGARTVLLVNDVNRHLADHEHTDLVISRLDELIDVLENGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PEF2</accession>
    <name>A0AAN6PEF2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_36587</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854400">
        <property type="protein sequence ID" value="KAK4039459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PEF2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051061">
        <property type="entry name" value="Zinc_finger_trans_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059009">
        <property type="entry name" value="Znf_C2H2_17_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059095">
        <property type="entry name" value="Znf_C2H2_17_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179:SF24">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26177">
        <property type="entry name" value="zf_C2H2_17_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26176">
        <property type="entry name" value="zf_C2H2_17_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="184"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="54"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="215"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="75"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4039459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="311" mass="34560" checksum="D6177FFBA0128151" modified="2024-10-02" version="1">MSVVYEPRSFIHDGGYPPMDDHHDPSPEADRFTDPTDAVVNELATTVATFTTPHPQYVDTTEPRLDLPVAPPAPTTATTPKEESPTATTPQRIKAIPKPDREVTRNLDGKFICTWPGCAEEPKEFIRKCEWNKHMDKHDRPYKCAAAGCEKLPGFTYSGGLLRHEREVHGKHGGPKNSFYCPHPNCKRHSGKGFSRQENLNEHLRRVHTLNGAALNGAEGETDDGASDNAAVAAAGGSGQKRKRDDQGDDSDLREEIKRVRQENDELRRQVQAQTQQTVIMMQKISDLQRTLETQMPTAVPTAAMTTTTMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PEU7</accession>
    <name>A0AAN6PEU7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_16423</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854396">
        <property type="protein sequence ID" value="KAK4039611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PEU7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052969">
        <property type="entry name" value="Thr-specific_kinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47763">
        <property type="entry name" value="ALPHA-PROTEIN KINASE VWKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47763:SF1">
        <property type="entry name" value="DUF659 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26200">
        <property type="entry name" value="Rcat_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="2">
        <location>
            <begin position="873"/>
            <end position="928"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4039611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1093" mass="120516" checksum="7EC27CB37326455C" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PF32</accession>
    <name>A0AAN6PF32_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Malate/L-lactate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_36496</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LDH2/MDH2 oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854398">
        <property type="protein sequence ID" value="KAK4039542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PF32"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1530.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.60">
        <property type="entry name" value="Hypothetical oxidoreductase yiak, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043144">
        <property type="entry name" value="Mal/L-sulf/L-lact_DH-like_ah"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043143">
        <property type="entry name" value="Mal/L-sulf/L-lact_DH-like_NADP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036111">
        <property type="entry name" value="Mal/L-sulfo/L-lacto_DH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003767">
        <property type="entry name" value="Malate/L-lactate_DH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11091:SF0">
        <property type="entry name" value="MALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11091">
        <property type="entry name" value="OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02615">
        <property type="entry name" value="Ldh_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89733">
        <property type="entry name" value="L-sulfolactate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4039542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="356" mass="38012" checksum="D7760CADD1EA15DD" modified="2024-10-02" version="1">MAQEDTKITVRHTAAEAFVVALLEASGVSRKNAEIVARGLVQADLRGVESHGVNRIPSYLARVRNGVLDPKTEPTLTQVTPVVAQVDGNNGFGFPAAHLAMETAVSMAQTFGIGMVSVKHSNHFGMSAWLVRQAVDAGMMSLVFTNSSPALPVWGGKSQLMGVSPIACGAPGGENSIPFILDMAPSVAARGKIYKALRRGEKIPPDWALDEEGKPTDDPEKALKGVMLPMGGPKGSALAIMMDVFSGVLSGSAFAGGVTGPYNMAKPGDVGHFIVAIKPDLFMSLDDFRQRMDVLYQRVVESDKMEGVERIYFPGELEQLTEERRLQDGIPFVQGEIDALNVEAERLGVPGIQQAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PFC8</accession>
    <name>A0AAN6PFC8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7729 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_36006</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854387">
        <property type="protein sequence ID" value="KAK4039954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PFC8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056146">
        <property type="entry name" value="DUF7729"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39460:SF1">
        <property type="entry name" value="C6 TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39460">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24855">
        <property type="entry name" value="DUF7729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7729" evidence="2">
        <location>
            <begin position="149"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4039954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="395" mass="41693" checksum="2CA29C43CCD64543" modified="2024-10-02" version="1">MTSAAASSPAGQAPLRSSRPGRRLPSMHRRPTTPLAVILAVFVCFVSHALAAAPNAAVPVETLAVDHRSPYQGGQRWAMLPAHELQRRKVQKRATSEESESTTESSDSTTESSERSKTSATASVTTTFSIAVGSSKPSSSSTTVSASPLPSILDSMASEFSPGPNGAAAPCPIFINSFLTNPTFKKCYPLSMLFDRSRSFFEAQRSLVSITRTLDATCAANATFCSTYLAELAQNLTATENCGTDYQLGLSSVVDAYRAMLAYAPVYSAGCLRDPDTKAYCYANAVTNLTNPSTTYFYFLPLNKSLPATTVPACGYCLQQTMTLYQAATADRRQLIANTYVSAAKQANVICGPGFVNETLAAEVIPSGAAVVVRVSAWLATALPLLVGAAVVGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PFQ9</accession>
    <name>A0AAN6PFQ9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase M20 domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_46422</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase M20A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854382">
        <property type="protein sequence ID" value="KAK4040179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PFQ9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05672">
        <property type="entry name" value="M20_ACY1L2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.360:FF:000004">
        <property type="entry name" value="Peptidase M20 domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052030">
        <property type="entry name" value="Peptidase_M20/M20A_hydrolases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017144">
        <property type="entry name" value="Xaa-Arg_dipeptidase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30575">
        <property type="entry name" value="PEPTIDASE M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30575:SF0">
        <property type="entry name" value="XAA-ARG DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037226">
        <property type="entry name" value="Amidohydrolase_ACY1L2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="3">
        <location>
            <begin position="179"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4040179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="408" mass="43394" checksum="98B2AB0749D3389C" modified="2024-10-02" version="1">MANDMASVINDEIQRRNGELSSINMHIHANPELAYEEHKAHDAFVSTLRSLGFEVTPHAYGLATAFSADFGSGGRLVVYNAEYDALPGIGHACGHNLIASASFAAFLGAAAALKTSGQPGRVRLLGTPAEEGGGGKLKLIAEGAYKGAAACLMVHPGPGHNLPPGIHGVAFVHMLANVKMRVHFTGREAHAAIAPWDGVNALDAVCLSYNAVSMLRQQIRPYERIHGVFRAAGDRPNVTPADCTVEYYCRSATKRGAEALWERVRKCFEGAAVATGCAMRVEPLNSYADVRPSRGLCEAYVDAMPAGTVALDKPADILAGSTDMGDVCYECPGFHGVFGIDTKEGEANHTKGFAAASGTQDAFERALECGRGMAAAGWRVLSDDAFAERVRREWEEDMKRAAEGKLAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PG24</accession>
    <name>A0AAN6PG24_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nucleotide-diphospho-sugar transferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_17370</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 34 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 77 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854425">
        <property type="protein sequence ID" value="KAK4038566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PG24"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008630">
        <property type="entry name" value="Glyco_trans_34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005069">
        <property type="entry name" value="Nucl-diP-sugar_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31306">
        <property type="entry name" value="ALPHA-1,6-MANNOSYLTRANSFERASE MNN11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31306:SF3">
        <property type="entry name" value="NUCLEOTIDE-DIPHOSPHO-SUGAR TRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03407">
        <property type="entry name" value="Nucleotid_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleotide-diphospho-sugar transferase" evidence="6">
        <location>
            <begin position="178"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4038566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="392" mass="44077" checksum="FBB7DBECE50A9B7D" modified="2024-10-02" version="1">MTPLQNLPQSWRRLIFFLPVLVTLILATGFYNGLIPKPPLPKVVFDDPAAGPFHQTCGAGPPPAALDSLPDVIRALWAPLVLPITAPAFTTIDGEKKRLPPPSQLIHTEPLGQRICILDLDNREFADNGDIFSSRLPAWDNLGGPAAGFLSHYLYAMIHGYSYKFIRAPKYADRAPHWAKVVFTREMLKQYDVVVMVDSDAMFATPQVPLEWLLNYWKIGPDALVAMPEDPAGDPNFDARRRVNVNSGFIIAQAGEKTQRLFRDWAECPSETRYPGCAVWKERPFHEQSAFSSHVRYNFLDGYSIDSHPQYIRTIPCHEANGYPEVSGCGCVGQFVRHYWAHKNLTIPEFNHNIMAALTPLLVQAAYKQPGIVEDYRAKVLDGAQILDRRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PG56</accession>
    <name>A0AAN6PG56_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_46321</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854379">
        <property type="protein sequence ID" value="KAK4040338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PG56"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050228">
        <property type="entry name" value="Carboxylesterase_BioH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43194">
        <property type="entry name" value="HYDROLASE ALPHA/BETA FOLD FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43194:SF2">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN LPX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="70"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4040338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="366" mass="41299" checksum="775A25787394A665" modified="2024-10-02" version="1">MSLFTNFTFKWLRWRRPTAPLQPLPDGIERFFIDTPGGKIEVLHAHPQPPQQTPPPPTATETHRPHANAPPLFFVHGGMGGAWVWLEYLRFFAARGVPCYAVSLRGHGGSYYPSYLRMVYATTKRMLADDVLAGLRWAQEREAGREVVLVGHSSGGGLCQFVLSEGEARVRALVLVAAVPGFGSDRVYQNWMKLDPWFIPRMIFHLWHPNSPLSHPAMTRRAFFSDEQTDAYVEAFQDKASPYESFVWALGMTKPFINQQNVLSQTTGSGNGQRVMVLSGELDKIMTLPIMEDLAHTYRTTYSKMVQQQQLQGEDAEVVPILGEGDRDNTGHGVRYCLVPRAGHHLQNDVPWEIGAHRLLAFYEQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PGH8</accession>
    <name>A0AAN6PGH8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_37217</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854418">
        <property type="protein sequence ID" value="KAK4038806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PGH8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04077">
        <property type="entry name" value="Peptidases_S8_PCSK9_ProteinaseK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000007">
        <property type="entry name" value="Subtilisin-like serine protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034193">
        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF11">
        <property type="entry name" value="CEREVISIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 6" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042824537" evidence="8">
        <location>
            <begin position="21"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="9">
        <location>
            <begin position="165"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="398"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="407"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4038806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="420" mass="43214" checksum="D68348006C77AE1D" modified="2024-10-02" version="1">MAGRLLACFTLALSALGVSGLPTSSNKTEPYIGVPIVNPGILNAIPNRYIVVYNNTFNDDDIDLHETSVIKTIAKRNIAKRSLTGKLLSTTVDTYKIGNWRAMALEADDLMINEIFSAQEVSYIEQDAYISLNARSVQSQTTSGLARISHADAGARTYVFDSSAGEGITAYVVDTGIRVTHSEFEGRATFAANFIDNVDDDEQGHGSHVAGTIGGKTFGVAKKVNLVAVKVLGADGAGSNSGVLAGMQFVANNATAMGLAGKAVMNMSLGGGANRAINSAINQIEAAGVVPVVAAGNESQDTANTSPGSAEAAITVGAIDQTNDVMADFSNFGQGVDIFAPGVDVLSVGIKSDTSTNVLSGTSMASPHVAGLAAYLMALEDITGVQAVGDRIKELAQGTGARASGTPRGTTTLIANNGFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PGP6</accession>
    <name>A0AAN6PGP6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_35555</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854377">
        <property type="protein sequence ID" value="KAK4040412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PGP6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10170">
        <property type="entry name" value="ASKHA_NBD_HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF5">
        <property type="entry name" value="HEAT SHOCK 70 KDA PROTEIN 12A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4040412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="342" mass="36762" checksum="ED6871D82EF410C9" modified="2024-10-02" version="1">MQPSVLGITNRLGSWGSGIAPNEKRVILFKLALLHNDDLVRDHPHSDCLAAVREALGDIEDAGQTGLSVVAEYMKRMWADGAQYLLHMLSAHGLVPNDVDICFVFGIPGVWSESSIVRMKEAIHQSGMLLFKGVPAPMGLTLEPEAAAMAINPGLIKNGLLKACVLTYVPSPSAERSSSLPGPHHACDFISYELASLTPFTVKECVPGEGGLYGDMFMKRALRSFLKQQVESTVGTNIASVDWANCEAAVEKVWATVCAQKAEQMCDTSWSPPLEVCRLDGTLLSSVTLYGADIVPVLRSITDGILELTHAQVNAVGAKKEGQTPDRIIVVGGFGCNKFLKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PGT0</accession>
    <name>A0AAN6PGT0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thioredoxin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_35599</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854378">
        <property type="protein sequence ID" value="KAK4040362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PGT0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00570">
        <property type="entry name" value="GST_N_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050983">
        <property type="entry name" value="GST_Omega/HSP26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968:SF8">
        <property type="entry name" value="S-TRANSFERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G00590)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="5"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="3">
        <location>
            <begin position="93"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4040362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="234" mass="25399" checksum="95D48F25EA37FD6D" modified="2024-10-02" version="1">MASQDKLILYTNHGCPWAHRAHIVLEELKIPFEEVIIDLSVPRTPEYLKINPRGLVPALSYNGEIIIESGIVAQFLADAYPSHLVPASDAPGGALRRARIALFVDAFISKLNGALFGFFTAKTEEEKQALVDKAVAALLSEVEPLLADASPFFGGSETITLAEVLTGSFALRLKSLTAAEVYPKAIWTAIEEKAPNYVRWSAAVVAHPSVTSIYDEERVVEGTKARIAKIRASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PGW2</accession>
    <name>A0AAN6PGW2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">1-phosphatidylinositol-3-phosphate 5-kinase</fullName>
            <ecNumber evidence="2">2.7.1.150</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Type III PIP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">C8A01DRAFT_16222</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13609"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57923"/>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.150"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.150" evidence="2"/>
    <dbReference type="EMBL" id="MU854390">
        <property type="protein sequence ID" value="KAK4039853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000285">
        <property type="term" value="F:1-phosphatidylinositol-3-phosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03334">
        <property type="entry name" value="Fab1_TCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17300">
        <property type="entry name" value="PIPKc_PIKfyve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.810.10:FF:000001">
        <property type="entry name" value="1-phosphatidylinositol 3-phosphate 5-kinase FAB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000007">
        <property type="entry name" value="1-phosphatidylinositol 3-phosphate 5-kinase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000283">
        <property type="entry name" value="1-phosphatidylinositol-3-phosphate 5-kinase (Fab1)"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="2-Layer Sandwich"/>
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    </dbReference>
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        <property type="entry name" value="Phosphatidylinositol Phosphate Kinase II Beta"/>
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    </dbReference>
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        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
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        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
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        <property type="entry name" value="PInositol-4-P-4/5-kinase_C_sf"/>
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        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
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        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
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        <property type="entry name" value="Znf_FYVE_PHD"/>
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        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
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        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 3-PHOSPHATE 5-KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 3-PHOSPHATE 5-KINASE-RELATED"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="7 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="14">
        <location>
            <begin position="417"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="PIPK" evidence="15">
        <location>
            <begin position="2052"/>
            <end position="2379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="103"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="232"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="333"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="502"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1535"/>
            <end position="1778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1828"/>
            <end position="1850"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1864"/>
            <end position="1959"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="2063"/>
            <end position="2091"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="147"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="182"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="511"/>
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        </location>
    </feature>
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        <location>
            <begin position="1558"/>
            <end position="1588"/>
        </location>
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            <begin position="1834"/>
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        </location>
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        <location>
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        <location>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00012009"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00075294"/>
        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00781"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51455"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK4039853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="2379" mass="262784" checksum="CEC9DBD580479FC7" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PH13</accession>
    <name>A0AAN6PH13_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bola-like protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_16213</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BolA/IbaG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854390">
        <property type="protein sequence ID" value="KAK4039855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:mitochondrial matrix"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BolA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR46230:SF7">
        <property type="entry name" value="BOLA-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01722">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82657">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="96"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4039855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="108" mass="12327" checksum="1D5536557D624C0A" modified="2024-10-02" version="1">MASHTPLEDSIRQKITTALKPTTLEIHNDSHLHAHHEPMQGVTSKETHFRLIITSEAFQTKMQPARHRLVYSLLKDELAQEGGIHALQLRTMTPEEEAKRRAQEAEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PHB4</accession>
    <name>A0AAN6PHB4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_16063</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854386">
        <property type="protein sequence ID" value="KAK4040020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PHB4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
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        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47840:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47840">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="521"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="34"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="302"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4040020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="719" mass="78721" checksum="34861B066A2B1150" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PHC7</accession>
    <name>A0AAN6PHC7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phospholipid:diacylglycerol acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_45746</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854365">
        <property type="protein sequence ID" value="KAK4041019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000147">
        <property type="term" value="P:actin cortical patch assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003386">
        <property type="entry name" value="LACT/PDAT_acylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030125">
        <property type="entry name" value="SPIN90/Ldb17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018556">
        <property type="entry name" value="SPIN90/Ldb17_LRD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13357:SF1">
        <property type="entry name" value="NCK-INTERACTING PROTEIN WITH SH3 DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13357">
        <property type="entry name" value="SH3 ADAPTER PROTEIN SPIN90 NCK INTERACTING PROTEIN WITH SH3 DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02450">
        <property type="entry name" value="LCAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09431">
        <property type="entry name" value="SPIN90_LRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="SPIN90/Ldb17 leucine-rich" evidence="3">
        <location>
            <begin position="796"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="977"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="992"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1036"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1071"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1098"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1113"/>
            <end position="1122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4041019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1122" mass="125357" checksum="31ABD9E625C5A187" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PHG8</accession>
    <name>A0AAN6PHG8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Eukaryotic peptide chain release factor subunit 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_15135</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic release factor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854364">
        <property type="protein sequence ID" value="KAK4041079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PHG8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018444">
        <property type="term" value="C:translation release factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.60:FF:000001">
        <property type="entry name" value="Eukaryotic peptide chain release factor subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.960.10:FF:000001">
        <property type="entry name" value="Eukaryotic peptide chain release factor subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000006">
        <property type="entry name" value="Peptide chain release factor subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.960.10">
        <property type="entry name" value="eRF1 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.60">
        <property type="entry name" value="eRF1 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042226">
        <property type="entry name" value="eFR1_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024049">
        <property type="entry name" value="eRF1_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005141">
        <property type="entry name" value="eRF1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005142">
        <property type="entry name" value="eRF1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005140">
        <property type="entry name" value="eRF1_Pelota-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004403">
        <property type="entry name" value="Peptide_chain-rel_eRF1/aRF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03676">
        <property type="entry name" value="aRF1_eRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10113">
        <property type="entry name" value="PEPTIDE CHAIN RELEASE FACTOR SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03463">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03464">
        <property type="entry name" value="eRF1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03465">
        <property type="entry name" value="eRF1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01194">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55481">
        <property type="entry name" value="N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eRF1/Pelota-like N-terminal" evidence="5">
        <location>
            <begin position="6"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4041079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="435" mass="48805" checksum="09415794B1A916A4" modified="2024-10-02" version="1">MSDPNASEAEKNIEIWKVKKLIKRLEAARGNGTSMISLIIPPKDQISRAAKMLAEEYGTASNIKSRVNRQSVLSAITSTQQRLKLYNKVPPNGLVVYCGEILTSEGKERKVNIDFEPFKPINTSLYLCDNKFHTEALAELLESDQKFGFIIMDGNGALFGTLSGNTRDIVQKFSVDLPKKHGRGGQSALRFARLREEKRHNYVRKVAELAVQNFITNDKVNVGGIVLAGSADFKNDLNASDLFDGRLQAKVIKVVDVSYGGENGFNQAIELSSETLGNVKFIQEKKLIGKYFEEISQDTGRICYGIEDTLKALELGAVEILIVFENLEIMRWTLKDSNGSEIILHTTKQQDEANRDKFMDKETGQEMEVVSQESFLEWVAEHYKDFGATLEFVSDRSTEGNQFVKGFGGIGGILRYKVNFEQLAEVDDDDDYYDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PHS2</accession>
    <name>A0AAN6PHS2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GIT Spa2 homology (SHD) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_36631</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854401">
        <property type="protein sequence ID" value="KAK4039421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PHS2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013724">
        <property type="entry name" value="GIT_SHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08518">
        <property type="entry name" value="GIT_SHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00555">
        <property type="entry name" value="GIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GIT Spa2 homology (SHD)" evidence="2">
        <location>
            <begin position="477"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="453"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4039421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="608" mass="66921" checksum="FB0D5A3550553706" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PIM8</accession>
    <name>A0AAN6PIM8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">At2g23090 like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_46736</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854390">
        <property type="protein sequence ID" value="KAK4039841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PIM8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1050.10">
        <property type="entry name" value="At2g23090-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039713">
        <property type="entry name" value="At2g23090-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039438">
        <property type="entry name" value="At2g23090-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007513">
        <property type="entry name" value="SERF-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026939">
        <property type="entry name" value="ZNF706/At2g23090_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33788">
        <property type="entry name" value="OS07G0114300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33788:SF1">
        <property type="entry name" value="ZINC-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04419">
        <property type="entry name" value="SERF-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12907">
        <property type="entry name" value="zf-met2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118359">
        <property type="entry name" value="Expressed protein At2g23090/F21P24.15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small EDRK-rich factor-like N-terminal" evidence="2">
        <location>
            <begin position="3"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="At2g23090-like zinc-binding" evidence="3">
        <location>
            <begin position="38"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4039841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="80" mass="8587" checksum="18B34E6DB135F65A" modified="2024-10-02" version="1">MGGGNGAKAAQKRARNDKKAGTKAVSQLKTNTAAMSIICNQCKQTFLSTSREPQLTLHAVNKHNATLPQCFPEFKVAEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PIW0</accession>
    <name>A0AAN6PIW0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD(+) diphosphatase</fullName>
            <ecNumber evidence="4">3.6.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">C8A01DRAFT_46617</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + beta-nicotinamide D-ribonucleotide + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60876"/>
            <dbReference type="Rhea" id="RHEA-COMP:15698"/>
            <dbReference type="Rhea" id="RHEA-COMP:15719"/>
            <dbReference type="ChEBI" id="CHEBI:14649"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:144029"/>
            <dbReference type="ChEBI" id="CHEBI:144051"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:60877"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Nudix hydrolase family. NudC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.22" evidence="4"/>
    <dbReference type="EMBL" id="MU854387">
        <property type="protein sequence ID" value="KAK4039961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PIW0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035529">
        <property type="term" value="F:NADH pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019677">
        <property type="term" value="P:NAD+ catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006742">
        <property type="term" value="P:NADP+ catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03429">
        <property type="entry name" value="NUDIX_NADH_pyrophosphatase_Nudt13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000042">
        <property type="entry name" value="Probable NADH pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050241">
        <property type="entry name" value="NAD-cap_RNA_hydrolase_NudC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015375">
        <property type="entry name" value="NADH_PPase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049734">
        <property type="entry name" value="NudC-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015376">
        <property type="entry name" value="Znr_NADH_PPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42904:SF6">
        <property type="entry name" value="NAD-CAPPED RNA HYDROLASE NUDT12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42904">
        <property type="entry name" value="NUDIX HYDROLASE, NUDC SUBFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09296">
        <property type="entry name" value="NUDIX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09297">
        <property type="entry name" value="Zn_ribbon_NUD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="11">
        <location>
            <begin position="260"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="230"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="250"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK4039961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="422" mass="45985" checksum="26FF85501D364843" modified="2024-10-02" version="1">MSIPALPLLLPTEDSHLTQKFGRETANYFSGSPLNRLSFLRTDPVFLRFAFAHPHARFLLLNNLAPLVQASDTAHLAFASHADVAPLTGADPFARTEAEMLREYDSSVEQVMVVFLGVDEKGVLPLPSDVEGREEAFGYRDFRGAPYFAVDVTPRGKVAGAAEALIEKMTGKGFAFHDNSPRHMGLQAGQAAMYGQARALIDWNARTPFCAQCGQPTLSVHAGTKRVCPPTDKAGTADGQPPRERKPCTTRGTVSNHSFPRTDPTVIMAVLSADGTKLLLGRQRRWPQDWFSTLAGFQEPGESIEEAVRREVWEESGVRVGRVILHSSQPWPFPASLMIGAIGQALPGEGEEIYLGHDAELESAKWFPLEEVKEALVTGVSSLGGPAPEGYVEGSLRLPPQTAIANRLITAVVEGYWVQSRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PJJ9</accession>
    <name>A0AAN6PJJ9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_34877</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854363">
        <property type="protein sequence ID" value="KAK4041145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PJJ9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF16">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4041145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="230" mass="27240" checksum="5B17B6F02CB54E30" modified="2024-10-02" version="1">MAYSIRPATYADLPAIIRLYLVDFWDEQLMDLLHPFRNKHPTDFERFIRDMLTERWWTLGLEQCVEVLLTDRERVVGFAWWRRSWGDEEKRRDTEGWFTLRRWLSPITIFFIQLRTRLWPYRCADPTMAGAEKRALPAILPLLRDPPSRQKAWHLLTLAVDPAFQKMGLGTRLVQHGLSRGDKEDLTAWLISREGLEEWYGRFGFVQKGRANIGELTKWNGGAVMFRESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PK10</accession>
    <name>A0AAN6PK10_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1746 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_33881</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854346">
        <property type="protein sequence ID" value="KAK4042117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PK10"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044695">
        <property type="term" value="C:Dsc E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032933">
        <property type="term" value="P:SREBP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038967">
        <property type="entry name" value="Dsc4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013715">
        <property type="entry name" value="DUF1746"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39405">
        <property type="entry name" value="DSC E3 UBIQUITIN LIGASE COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39405:SF1">
        <property type="entry name" value="DSC E3 UBIQUITIN LIGASE COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08508">
        <property type="entry name" value="DUF1746"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1746" evidence="3">
        <location>
            <begin position="71"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4042117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="341" mass="36705" checksum="0AD267A9AEFD74E8" modified="2024-10-02" version="1">MNHDDPGPSSAARQLPPRSDGEYDDAGEHAVRAEDNPGDGRPTEDSPSRRQEKRREGLVKKLELVSHLQKSLDMIVFVYICTLYYMECSFLRFLLRLAPHYSFLTPKEGLLLPAEHPHIYTIFVPSVLCILAHIFFGLPEAGEATRGYLHGGVIIDFIGQKPPTSRLAFLSFDLVILAAQCLMLAVHQERESLKKAVSPALRTIAPSGDQATQAAAAAVETTQDHDAEERGVLRDQTYVGDGGGGGTELQPLSGSGGRRTEGNAADDEQAGDTYSSAAASADMLDIIRSGNAVLANFHVIHAVRAVGNGAQSAAAYSLQTLGYGATLAALTAERRSRLLQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PK86</accession>
    <name>A0AAN6PK86_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_45268</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854354">
        <property type="protein sequence ID" value="KAK4041623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PK86"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4041623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="355" mass="40196" checksum="BFAA3621A5483252" modified="2024-10-02" version="1">MSGQSPAFPLAEQPAGKAAGESESRQLSIADLDGDHRDLLVRAIARILSTELAEITYAQIIDGLPIADVAFDRRAHFAAGHPMDHFHEELCPGMLDRAREFRDGFRPEILTFNSLLLHGYRACAPGSRGFKTRLIEMVAVAVHQIAAILYELDTSVHKDDGIVEWAPPKSESWWWSCYPEGPLPTLFSHGWYVDYDQYPKHVADVVGYWAEARILGGVVLFDRRKPDAEPSADPDAVYFHSDREDVTYRIYQLLPEQRKALLDFLIADEPPSASPLPILGDEENRVRVDPEEPIQTTGIYRDPWERKELAPDAGDSRLRDVWDVIEYPARDDFSASRRRAFERKSRVLDAEVSDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PKN7</accession>
    <name>A0AAN6PKN7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">chitinase</fullName>
            <ecNumber evidence="4">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">C8A01DRAFT_45910</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="4"/>
    <dbReference type="EMBL" id="MU854369">
        <property type="protein sequence ID" value="KAK4040799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PKN7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06548">
        <property type="entry name" value="GH18_chitinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.10:FF:000005">
        <property type="entry name" value="Endochitinase B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000095">
        <property type="entry name" value="Endochitinase B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF317">
        <property type="entry name" value="CHITINASE 12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="14">
        <location>
            <begin position="60"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK4040799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="453" mass="49917" checksum="952ED7D29436CB56" modified="2024-10-02" version="1">MPRLLRPYHLCLIFFAISAVLVGILIGPRSFIPNSLTKTSPTPPTPQATATMGGGPTPGYLSVAYFVNWAIYARKHRPQDLPVEKLTHVLYAFANVRPESGEVYLTDSWADTDIHWEGDSWNDSGTNLYGCLKQLNLLKRRNRNLKVLLSIGGWTYSSNFKQPASTAQGRQTFASSAVELVSRLGFDGLDIDWEYPQSASEAADFVSLLAEVRSALDHHATTVSPSNPPHFELTVACPAGANNYNNLDIPAMDRYLDFWNLMAYDYAGSWDRVAGHQANLYPSRDNATSTPFSTEVAVQAYVGRGVAPGKIVMGMPLYGRAFEGTGGLGMPYSGVGEGTWENGVHDYKKLPLAGAEVRVDHDAGASYCYQPDRQVLVSYDTVDMARRKAEYIRERGLGGGMWWESSADKEGPESLIGNVVDVLGGPNALQWRENCITYPHTKYDNLREGFPNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PKS9</accession>
    <name>A0AAN6PKS9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_46370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854380">
        <property type="protein sequence ID" value="KAK4040300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PKS9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052356">
        <property type="entry name" value="Thiol_S-MT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45036:SF1">
        <property type="entry name" value="METHYLTRANSFERASE LIKE 7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45036">
        <property type="entry name" value="METHYLTRANSFERASE LIKE 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4040300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="288" mass="31988" checksum="8C3BE18EC6C37BEE" modified="2024-10-02" version="1">MPLPDSLASLLHPWQFMALSLSFLPPTLLSALLALDLRTLLSPSRLRAAWFGRFWARVGPDVRLHAEANVIPLLQGHVTHGIIPPASQTTTTTTNSQERPHPPVSGTVLEIGPGSGMWTSLFTPQTLPSIRKVYGVEPNTTVHPLLRQQITAAGLTETYEILPLGIEDLAASGRVPLASVDCIVTVMCLCSIPEPRHNMAQLYGYLKPGGRWYAYEHVKCFREQGWGMRAYQAFLNILWPRLIGGCEMCRDTGKWLKEAGPWSKVDLCQLEGEPWYFTMPHVIGVLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2025-10-08" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PLV4</accession>
    <name>A0AAN6PLV4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ABC-2 type transporter-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">C8A01DRAFT_34429</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854356">
        <property type="protein sequence ID" value="KAK4041474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03233">
        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000054">
        <property type="entry name" value="ABC multidrug transporter atrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029481">
        <property type="entry name" value="ABC_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034001">
        <property type="entry name" value="ABCG_PDR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14510">
        <property type="entry name" value="ABC_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="594"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="644"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="676"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="817"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1240"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1273"/>
            <end position="1292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1312"/>
            <end position="1340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1352"/>
            <end position="1371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1383"/>
            <end position="1405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1508"/>
            <end position="1526"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="210"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="900"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="860"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="82"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="104"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="871"/>
            <end position="887"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK4041474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1567" mass="173000" checksum="B8E54D1BE9AF4D94" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PM78</accession>
    <name>A0AAN6PM78_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Dynamin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_43650</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854327">
        <property type="protein sequence ID" value="KAK4043526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PM78"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36681">
        <property type="entry name" value="NUCLEAR GTPASE, GERMINAL CENTER-ASSOCIATED, TANDEM DUPLICATE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36681:SF3">
        <property type="entry name" value="NUCLEAR GTPASE, GERMINAL CENTER-ASSOCIATED, TANDEM DUPLICATE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin N-terminal" evidence="2">
        <location>
            <begin position="23"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4043526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="409" mass="45205" checksum="4038DB06A9B87205" modified="2024-10-02" version="1">MPLPEAAQVDRLRSRATPQRTVVGVVGSTGAGKSSTINAVLDEEGLVPTNPMRACTASVTEIAYNPSDNKDEKYRAEIHFQSRDEWMTELRAGLDDMQTAQVDSDTGGSTGNGGDASVPLQKLRLVYPTLKSDDLRDGSVTIETLADEASVKDLLVAVKQIASSNSKDFLELLKPFIDSKEKTGDKTEEPGTIEYWPLINAVKIFVRSPILKTGLILVDLPGIHDSNAARAAIANGYIKQCSRLWIVTPITRTVDDKTTQTLLGDSFKRQLQFDGTYSKVTMICSKTDEFSVTDFLERILPPGHPVHQLNTQYQLLETERNKHREAIVTSKSGRAEINRARKRGHRATTSAARKRIKLQPTSETKDGDNSELEDKSVASEAEVENEQVSRETVQQRLEQALSRRNAPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PME4</accession>
    <name>A0AAN6PME4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_44325</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854337">
        <property type="protein sequence ID" value="KAK4042705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PME4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11070">
        <property type="entry name" value="CYP56-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038872">
        <property type="entry name" value="Put_GTT3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41807">
        <property type="entry name" value="GLUTATHIONE TRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41807:SF1">
        <property type="entry name" value="GLUTATHIONE TRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="2 3" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="852"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="495"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="671"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="495"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="697"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="3">
        <location>
            <position position="548"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4042705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="971" mass="107139" checksum="85F30B09412A588B" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PMG7</accession>
    <name>A0AAN6PMG7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_32092</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854324">
        <property type="protein sequence ID" value="KAK4043773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PMG7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4043773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="69" mass="7618" checksum="D21DF0A25BFE9ECD" modified="2024-10-02" version="1">MDSSKTTQQQQKNTNQPTEGNPLHKVADSVKTAFQAHSANPGPAVPKEFNVQEEGTKEERRAKADELNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PMY7</accession>
    <name>A0AAN6PMY7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_43349</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854324">
        <property type="protein sequence ID" value="KAK4043787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PMY7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039113">
        <property type="entry name" value="ATG29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039362">
        <property type="entry name" value="ATG29_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40012">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40012:SF1">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="189"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="276"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="335"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4043787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="437" mass="44331" checksum="4A62F38A0FD7BC42" modified="2024-10-02" version="1">MSTSGCPSTAETSSTPGQAAKFDVTVDFLLQMAAYLTERHTSQLRAHMLKAAAARGSNAPSPVPGAEPAGSYQAAMDPTRRASLGTGRAPSALSVRKDTATPLPKNEEEHSVAAAVGPSIKSAIPIRPGSSRNSSSSTAVQAQPGSRPGTARLGDPQRRRFSYLPTPVAQAQQHPPQEEDDTEIPSPSPAASTTSSSSSSSSPVESRIIRRPPRFGGGNNHFNDADDDDDDEAEPAFLPFTHQTGGGAPTTLQGSGSGQDLGATLRGNNLRDLAGRGRQQAAASAGDASSQSQSQTSDSSVGSAAVISRRPGTAGGGGTDGQRRRLPAGHYQQGPLSPRRAAELAAAGGGGGGGGGRPGSSSRGKGGGGPSREGSDGAPSMGSSFSDLDDASVTQSALEEALASRMQDGTIGSRMSVIGGTIGHAFRSRYLPKPNRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PN27</accession>
    <name>A0AAN6PN27_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">U-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_43024</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854321">
        <property type="protein sequence ID" value="KAK4044088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PN27"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071218">
        <property type="term" value="P:cellular response to misfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045862">
        <property type="term" value="P:positive regulation of proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46803">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE CHIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46803:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE CHIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0697">Rotamase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="U-box" evidence="6">
        <location>
            <begin position="195"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4044088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="271" mass="30975" checksum="AEE2FEBB52FEAD53" modified="2024-10-02" version="1">MAKSTHLKDEGNRRFQAGDYVMAEALYSQALIADANNPALYTNRAMARLRLNQWDSAIADCAACLRLAPDSMKAHYSLSQAHLALRAHDDALRHALRAHALCVKAADKSLGTITAHVLKCKKERWDDLEKRRVRETAELEAEVLELMARERAQAVREQGDDEGGRREVDEEWGAKMARLREVFERARPEAERRREVPDWAIDDISFCVMVDPVITKTGKSYERASIVEHLRRQPQDPLTREPLYASELRPNLDLKQACDEFLQQNGWAADW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PN48</accession>
    <name>A0AAN6PN48_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PRELI-like family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_32872</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854332">
        <property type="protein sequence ID" value="KAK4043080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PN48"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006797">
        <property type="entry name" value="PRELI/MSF1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037365">
        <property type="entry name" value="Slowmo/Ups"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11158">
        <property type="entry name" value="MSF1/PX19 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04707">
        <property type="entry name" value="PRELI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50904">
        <property type="entry name" value="PRELI_MSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRELI/MSF1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4043080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="237" mass="26149" checksum="B0EC40B38ACF2E98" modified="2024-10-02" version="1">MVLTHTTTHTYSHPFPTVTLAFFLRYCSPQLNPFASHVLSTDTIASHLDPATGRLHTTRIHLKKSRLPPGVMKLLPSSLTGGTSDKASYILETSIVDMREGWMATESRNLNFVGVLSVVERQMYAVPKTKPPADNTDVETKVVFRSRLGERIRDRLGQAQAQAEAAVNEGSGGFFARLGARGIQRSIETLASTKTQDQLGKSREGMLMILERLRQTGIMGVLELRKMASQRGMDAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PN50</accession>
    <name>A0AAN6PN50_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_14127</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854344">
        <property type="protein sequence ID" value="KAK4042194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PN50"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="439"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="176"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="201"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="261"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="358"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4042194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="461" mass="49766" checksum="78F8784D788DD8A6" modified="2024-10-02" version="1">MAQHNSGASAAGTARPPAARLTKRAALSAPSAFQLFLEQRRRALRNSTSPESNPKIAFLEKPLTPSLSQPPLNHRALSSLHRKAKRSVLHHHSSKPPALAKLARLYRRHRNPERALRSFLLRRQLWRRTRRPFNMDFIDHLRHIQADEPSSDEDSGTLLTAVTVPAPRRPSPASKPAPVAASDLTAKTKTTGAKRKRDAPAEALTENANAETSRAAMMAKSQGTPPAPVANGTKSPKKRTLDAEKADVDVDARATKKAKTAKPAPTKAEAEAGSSKAAATATATTKTTAGPGPQKPVGQMEYFERRAHDMLTDPLGFDDYVYDSNKQTPRHVARSFAKYRRRQSQSPPPLVMSGALGPAPAANPANPKPKGSGSLAREAQKRAHQQKVEGRVQGLKGKGKAVEESSSAHEKGKAVVARQQAMANGGVGKRKEKRWLTNARQTGGKGGQHHQGGLVKYKKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PNK3</accession>
    <name>A0AAN6PNK3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">intramembrane prenyl-peptidase Rce1</fullName>
            <ecNumber evidence="10">3.4.26.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">C8A01DRAFT_43206</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>Hydrolyzes the peptide bond -P2-(S-farnesyl or geranylgeranyl)C-P1'-P2'-P3'-COOH where P1' and P2' are amino acids with aliphatic sidechains and P3' is any C-terminal residue.</text>
            <dbReference type="EC" id="3.4.26.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase U48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.26.1" evidence="10"/>
    <dbReference type="EMBL" id="MU854322">
        <property type="protein sequence ID" value="KAK4044052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PNK3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039731">
        <property type="entry name" value="Rce1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1/LyrA-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13046:SF0">
        <property type="entry name" value="CAAX PRENYL PROTEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13046">
        <property type="entry name" value="PROTEASE U48 CAAX PRENYL PROTEASE RCE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="244"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="332"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="CAAX prenyl protease 2/Lysostaphin resistance protein A-like" evidence="13">
        <location>
            <begin position="178"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="305"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="308"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK4044052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="383" mass="41745" checksum="3ADC59342BC621AB" modified="2024-10-02" version="1">MPAIADTLRKLNPWHKGKYSRTLPQCLTLDPRHAAPPPPPITTRAAYGLLILYALSYFIPFYLSRTTRPSPTLSRDAPSVIRARIRSVTLSCLACTGVTYVVLCRAGTTGGGAGGPKTTPLEALHLLGLWPAALWDSLRVLLLTATLFAGPLFSYLVVERGWADWVRLAPVREVWEEWTTWRNIIAGPVTEEILFRTASIPLMLLAQTTPTTTIFLTPIIFGLAHVHHFYEFRLTHPRVPAAAALLRSVFQLGYTTLFGAYATFLFLRTGSLLAVCAVHAFCNCMGLPQVWGRVEPLPVLAGGDVGEDEGHGDRDGRRQQQGGGGNGGRPSILWTVAYYALLVAGAVLWYRNLWVLSESGNALVPGSAFSRAASAWKIGVGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PNL2</accession>
    <name>A0AAN6PNL2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar-sorting protein SNF7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Vacuolar protein-sorting-associated protein 32</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_14492</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854351">
        <property type="protein sequence ID" value="KAK4041800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PNL2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000815">
        <property type="term" value="C:ESCRT III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1060">
        <property type="entry name" value="ESAT-6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF10">
        <property type="entry name" value="GH13992P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="202"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4041800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="225" mass="25493" checksum="F218B75287193CB4" modified="2024-10-02" version="1">MSGIWGWFGGGAAQKRKDTPKNVILDLRTQLEMLQKREVHLTRQIEEQEQIARKNVNTNKTTAKAALRRKKIHEHNLEQTLNHIGTIEQQVNAIESANINQETFMAMQRAGDAMKTIHGKLTPTKVDETMDKLQEYNRLNEEIADAMGSISVGPQLDDTELEDELEALQQQELEDKMLETGSVPVDSIQRLPTVKNAEIKGKAPAVAEDDEEEELRRLQAEMMPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PP53</accession>
    <name>A0AAN6PP53_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_14260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854346">
        <property type="protein sequence ID" value="KAK4042070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PP53"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4042070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="218" mass="24895" checksum="A198ED4635CD3678" modified="2024-10-02" version="1" fragment="single">SSRNSRHSIEANHNSSTQGAMEALRPRPSGTPSRRRHDYQRSRGHSARDGQAKDHKRSLQTRPRHSVEITRPLEDLGGGPVPRSKEKNDAFVQSWLQQTQARHSHLPETGHEKGRLQPAEQRRPSERGDKHRKRPRSLSGPPPPSPRRIEEPEYRFEKRARHKTRDDKYDYKAPAGNKRVSDQGFREHGPREAAGRRSQTTKGRHSVSGPRTNDFAGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PP56</accession>
    <name>A0AAN6PP56_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_42832</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854319">
        <property type="protein sequence ID" value="KAK4044402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PP56"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053157">
        <property type="entry name" value="Sterol_Uptake_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784:SF4">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="12"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="40"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="43"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4044402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="418" mass="45902" checksum="C86903B34F3460D2" modified="2024-10-02" version="1">MLRRSHKKSRAGCLECKRRHVKCDEQRPKCIICTLSERDCSYPPQSAATSAESGPNTPNTPSTPAADAQETPDASASWAAAVITSTASNASPVAGVPLPAIAGRGPTSPDDASQRPPEVNLGHMELLIRFNFEEHAPELNVEMHDFASKLLFKCALEAPYLMHQILAVSARRQAVLQPERANHFLENAMHLQTKAVSIYNETAAKAQIDQTNCSALLLFCSLLGRHLLADLLARRDADFGDFLARFLEFLSISRGLMAMSVSAWDLLLQSDIKHLVLWALEISQSTPQGQHCDGLQRLVAESTELDTSSKEACMTAIACLQVGFDSLLGGDTRNQRYLMVFMWAPAVPQKFTDLLAQRRPEAIAIMGHWAVLLHYTRSLWHVADSGSHLLQSISGYLGQGWEHWLSWPLSVVTANAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PP60</accession>
    <name>A0AAN6PP60_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">V-type proton ATPase subunit C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_31380</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.</text>
    </comment>
    <comment type="function">
        <text evidence="5">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. Reversibly leaves the enzyme after glucose depletion, causing the catalytic subcomplex V1 to detach from the V0 section.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the V-ATPase C subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854318">
        <property type="protein sequence ID" value="KAK4044591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PP60"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14785">
        <property type="entry name" value="V-ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000002">
        <property type="entry name" value="V-type proton ATPase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1460.10">
        <property type="entry name" value="subunit c (vma5p) of the yeast v-atpase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1180">
        <property type="entry name" value="Vacuolar atp synthase subunit c, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004907">
        <property type="entry name" value="ATPase_V1-cplx_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036132">
        <property type="entry name" value="Vac_ATP_synth_c_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10137">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10137:SF0">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03223">
        <property type="entry name" value="V-ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118203">
        <property type="entry name" value="Vacuolar ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00053565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4044591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="390" mass="43663" checksum="7F5D43557F49746B" modified="2024-10-02" version="1">MQPTQYILVSLPLRIFDDDPLAALTATVGRDNGETLPFSIPSFKIGTLDALVQHADDLAKLNAACEAAVAKVADSLKGILDGDEDKTTQQKMVNDKPTDHYLRTFQWNKVRYRADRPLGELIDNLQKELQNIDNDVKAKFNQYSGIKTTLAALQRKQTGNLATKSLTPIVNPSLLVQDSEYLETHLIVVPTNARKDFVRSYETLAPMVVPRSSIQVAQDDEFTLFAVTTFKKTSAEFLQKCREQKWTPRQYKYVEGGKEEEQRELDRVAREEKKAWGEALRLGRTGWSETVMILAHVMTLRVFVETVLRYGLPLEFVCALVKTTSKQAKKVKTALDSAYSYLGGNAFGRDKRGRVTKDDASLTSEMAAAGLGAAEGSEYTAYVYYEIDLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PP92</accession>
    <name>A0AAN6PP92_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">NEDD8-activating enzyme E1 catalytic subunit</fullName>
            <ecNumber evidence="8 10">6.2.1.64</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">C8A01DRAFT_31517</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalytic subunit of the dimeric E1 enzyme, which activates NEDD8.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>ATP + [NEDD8 protein] + [E1 NEDD8-activating enzyme]-L-cysteine = AMP + diphosphate + [E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine.</text>
            <dbReference type="EC" id="6.2.1.64"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Protein modification; protein neddylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ubiquitin-activating E1 family. UBA3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.64" evidence="8 10"/>
    <dbReference type="EMBL" id="MU854319">
        <property type="protein sequence ID" value="KAK4044462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PP92"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019781">
        <property type="term" value="F:NEDD8 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01488">
        <property type="entry name" value="Uba3_RUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.520:FF:000001">
        <property type="entry name" value="NEDD8-activating enzyme E1 catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.20:FF:000001">
        <property type="entry name" value="NEDD8-activating enzyme E1 catalytic subunit, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.520">
        <property type="entry name" value="Ubiquitin activating enzymes (Uba3). Chain: B, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.20">
        <property type="entry name" value="Ubiquitin-like 2 activating enzyme e1b. Chain: B, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014929">
        <property type="entry name" value="E2-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023318">
        <property type="entry name" value="Ub_act_enz_dom_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030468">
        <property type="entry name" value="Uba3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF6">
        <property type="entry name" value="NEDD8-ACTIVATING ENZYME E1 CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08825">
        <property type="entry name" value="E2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01181">
        <property type="entry name" value="E2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="E2 binding" evidence="11">
        <location>
            <begin position="347"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK4044462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="433" mass="48247" checksum="E3632F8250D8DC43" modified="2024-10-02" version="1">MASAEVYPASEPARWTYLDRIRTRPGPFTNPDMFSGEAVAAAMETMKILVIGAGGLGCELLKNLALSGFKDIHVIDMDTIDISNLNRQFLFRQADVGKSKADVAARFVEKRVKGVKITPHNCRIQDFDEDFYMQFQLVVCGLDSIEARRWINATLVNMVDEDVEDSYKPLIDGGTEGFKGQARVIFPTVTSCIECQLDMHAPRAAVPLCTLASIPRQPEHCIEWAHVIAWDQEKPFPQLDKDDPEHITWLYQKALLRAREFNIPGVTYSLTQGVVKNIIPAIAATNSVIAAACCNEALKIASNCAPFLGLPEENYMMYSGNDSVYTYTFKHEKKDDCPVCGQLARDLPVEASWTLSELVDSFAARPEAQLKKPSVRAEGKTLYMQSPPSLEAQTRPNLDKTLVELGLEDGQEIGVTDPAFATVVFKFRLRFKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2025-10-08" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PPF5</accession>
    <name>A0AAN6PPF5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_33089</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Regulates mitochondrial small subunit maturation by controlling 15S rRNA 5'-end processing. Localizes to the 5' precursor of the 15S rRNA in a position that is subsequently occupied by mS47 in the mature yeast mtSSU. Uses structure and sequence-specific RNA recognition, binding to a single-stranded region of the precursor and specifically recognizing bases -6 to -1. The exchange of Ccm1 for mS47 is coupled to the irreversible removal of precursor rRNA that is accompanied by conformational changes of the mitoribosomal proteins uS5m and mS26. These conformational changes signal completion of 5'-end rRNA processing through protection of the mature 5'-end of the 15S rRNA and stabilization of mS47. The removal of the 5' precursor together with the dissociation of Ccm1 may be catalyzed by the 5'-3' exoribonuclease Pet127. Involved in the specific removal of group I introns in mitochondrial encoded transcripts.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Binds to mitochondrial small subunit 15S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854335">
        <property type="protein sequence ID" value="KAK4042839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447">
        <property type="entry name" value="OS03G0856100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447:SF17">
        <property type="entry name" value="OS12G0638900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13812">
        <property type="entry name" value="PPR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="122"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="318"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1020"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1210"/>
            <end position="1302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="322"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1027"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1222"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="1235"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1247"/>
            <end position="1277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4042839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1322" mass="148999" checksum="333AB1197A3E5058" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PPL0</accession>
    <name>A0AAN6PPL0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Signal recognition particle subunit SRP72</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">C8A01DRAFT_44130</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the SRP72 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854334">
        <property type="protein sequence ID" value="KAK4042914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PPL0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000512">
        <property type="entry name" value="Signal recognition particle subunit SRP72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013699">
        <property type="entry name" value="Signal_recog_part_SRP72_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026270">
        <property type="entry name" value="SRP72"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031545">
        <property type="entry name" value="SRP72_TPR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14094">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14094:SF9">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08492">
        <property type="entry name" value="SRP72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17004">
        <property type="entry name" value="SRP_TPR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038922">
        <property type="entry name" value="SRP72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 9" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="Signal recognition particle SRP72 subunit RNA-binding" evidence="11">
        <location>
            <begin position="577"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="557"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="557"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="584"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="594"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="610"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="626"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR038922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK4042914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="682" mass="72859" checksum="63B2AA4F742512E9" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PQ20</accession>
    <name>A0AAN6PQ20_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein SSH4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Protein ssh4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">C8A01DRAFT_11820</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Components of the endosome-vacuole trafficking pathway that regulates nutrient transport. May be involved in processes which determine whether plasma membrane proteins are degraded or routed to the plasma membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SSH4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854316">
        <property type="protein sequence ID" value="KAK4044862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PQ20"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12910">
        <property type="entry name" value="SPRY_SSH4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000065">
        <property type="entry name" value="Ear1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035780">
        <property type="entry name" value="SPRY_Ssh4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0967">Endosome</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="8 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="18">
        <location>
            <begin position="74"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="314"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="317"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="411"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="460"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="476"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="501"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00025244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAK4044862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="519" mass="56465" checksum="4D02B907EAEB19CB" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PQN6</accession>
    <name>A0AAN6PQN6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Signal recognition particle subunit SRP68</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">C8A01DRAFT_13612</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SRP68 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854335">
        <property type="protein sequence ID" value="KAK4042835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PQN6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030942">
        <property type="term" value="F:endoplasmic reticulum signal peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005047">
        <property type="term" value="F:signal recognition particle binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15481">
        <property type="entry name" value="SRP68-RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3450.40">
        <property type="entry name" value="Signal recognition particle, SRP68 subunit, RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026258">
        <property type="entry name" value="SRP68"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034652">
        <property type="entry name" value="SRP68-RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038253">
        <property type="entry name" value="SRP68_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12860">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 68 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12860:SF0">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16969">
        <property type="entry name" value="SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038995">
        <property type="entry name" value="SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0733">Signal recognition particle</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="367"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="490"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="543"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="645"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="376"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="543"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK4042835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="668" mass="72140" checksum="4CA22C809846522E" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PT10</accession>
    <name>A0AAN6PT10_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_31643</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854320">
        <property type="protein sequence ID" value="KAK4044326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PT10"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="195"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4044326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="220" mass="19872" checksum="FD8407A2290C02CD" modified="2024-10-02" version="1">MPGIPFGALDNLKGKLKAAFKNRGEKKAAKKTEEPGAAGGAAAAAAPAAATTAAATEATKTDATKTETAAAAAPAEAPAAETAAAPAATGEALAAEPKAEEAPAPAAAAAETTAAAAAPAVEATPAPAAAPAVATTEATTAAAPATEATAAPAEAAAAPAATEAPAATEAPAATETTAAPAADAPAAEEKKEDAAAAATPAPAPAAAAAAAPAAPAAPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SK39</accession>
    <name>A0AAN6SK39_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_42231</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854890">
        <property type="protein sequence ID" value="KAK4031301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SK39"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="133"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4031301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="203" mass="21825" checksum="2518679E25C9D60F" modified="2024-10-02" version="1">MKLGASYQYQDVPQFKYAQPTDLQAHFTSHPAGGGQQHADHHATAEGGHYAQQHAAAPHPDWYGSYLAQTGHQDPYSAPHPPATHFGHQAAAPDPHLVAVQNALVKIENYYSKELGKFKVGLPKWNSHNPSDPTVGASASSSGAPAKATSKVPGQKPTAPAPKLPAPKPASQKPSSTKKCKKCRREGTKTKLEVHNKKHPTYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SL61</accession>
    <name>A0AAN6SL61_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GAF domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_51512</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the free Met sulfoxide reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854828">
        <property type="protein sequence ID" value="KAK4031393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SL61"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033745">
        <property type="term" value="F:L-methionine-(R)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.40:FF:000048">
        <property type="entry name" value="Free methionine-R-sulfoxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000614">
        <property type="entry name" value="FRMsr_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051330">
        <property type="entry name" value="Phosphatase_reg/MetRdx"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21021:SF15">
        <property type="entry name" value="FREE METHIONINE-R-SULFOXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21021">
        <property type="entry name" value="GAF/PUTATIVE CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01320">
        <property type="entry name" value="UPF0067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAF" evidence="2">
        <location>
            <begin position="92"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4031393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="195" mass="21161" checksum="9C64FCD7186457A6" modified="2024-10-02" version="1">MRLWNGILTHPLQVHADASNFAQGVTKEEAYQQVLDQAEGLFFEQRNWVCNLSNAASLLWHAYKSLPSPSNQVNWAGFYTLDPLSPPTRPQLILAPFQGKVACQTIAFGRGVCGAAAATKQTQLVADVDAFPGHIACDGDSRSEIVVPIVVGEGEEKRVVGIIDVDCAVVGGFDEVDRVWLERLAEVIAAACDWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SLG5</accession>
    <name>A0AAN6SLG5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NACHT-NTPase and P-loop NTPases N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_21139</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854725">
        <property type="protein sequence ID" value="KAK4031692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SLG5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031352">
        <property type="entry name" value="SesA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38886:SF1">
        <property type="entry name" value="NACHT-NTPASE AND P-LOOP NTPASES N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38886">
        <property type="entry name" value="SESA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17107">
        <property type="entry name" value="SesA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NACHT-NTPase and P-loop NTPases N-terminal" evidence="1">
        <location>
            <begin position="21"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4031692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="166" mass="18363" checksum="AAF2AEBCB7918C0E" modified="2024-10-02" version="1">MASPVSFGDAVAMAKIARRIAHAFTKGRKSAPSEFREVENQLYSLSAALAAFKNVCGADVAAVAIDAEQLPARFRNEEQDGVQTLSVILDSCKETLKHLEKIVQEYGVVSAPKDPSMSRLQRWNTELVRNYKKIAWTTEAGDLETLRSQLMIHTNSLELVLGIIMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SM02</accession>
    <name>A0AAN6SM02_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_50063</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854537">
        <property type="protein sequence ID" value="KAK4033326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SM02"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="536"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="282"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="543"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="560"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4033326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="570" mass="62723" checksum="394031948C963D3C" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SMD4</accession>
    <name>A0AAN6SMD4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ARP8-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_40954</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854591">
        <property type="protein sequence ID" value="KAK4032608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SMD4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10206">
        <property type="entry name" value="ASKHA_NBD_Arp8-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000232">
        <property type="entry name" value="Actin-related protein 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000066">
        <property type="entry name" value="Actin-related protein 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="517"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="540"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4032608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="762" mass="85410" checksum="E1E7A034CE4F361D" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SME3</accession>
    <name>A0AAN6SME3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_50595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854586">
        <property type="protein sequence ID" value="KAK4032667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SME3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4032667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="216" mass="24868" checksum="B55C1B1D3C800175" modified="2024-10-02" version="1">MEGAKTPIYQASSRSALLAALGGCIKGHESWHKAGILHRDIFPYNLMINEDPENLSWPFFLIDLDSATREQRNGTPGADDKMIGTWVFMAVGVLMREDHSFMHDLESFFWVLFWICIHWYGPGESRVVAEFEMWHDVRAGELAALKKGHVSHEGDFLRAAKRNFTPYYQPMIPWVNKLRKAVFPNGGRWEREDSGLYARMREILEKARKDPNVAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SMG2</accession>
    <name>A0AAN6SMG2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Exocyst complex component SEC3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_20237</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854580">
        <property type="protein sequence ID" value="KAK4032727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SMG2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4032727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="219" mass="23640" checksum="4C8CC47BE9DA278C" modified="2024-10-02" version="1">MSTPDPPPTTTTTNTTAQPPPQSSITHTAAIAAAILCPIALLLPTRGGGAGKRTLQNALLGGAAFWGFDRLAADYTGKSITARSGERWGSFFGISNNTKEEEVKEGGEKEKNAVGIMHNLPTERAARNKELMQAEKRRRAEAEGRVFDGGDGTKKGGLWERLWMGGEKEGWREKRLEEERKALESGKGYGGLIADQVREVWKGEDTKDGKGDGEGKKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SMV2</accession>
    <name>A0AAN6SMV2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Scytalone dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_40386</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the scytalone dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854548">
        <property type="protein sequence ID" value="KAK4033162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SMV2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030411">
        <property type="term" value="F:scytalone dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006582">
        <property type="term" value="P:melanin metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004235">
        <property type="entry name" value="Scytalone_dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049884">
        <property type="entry name" value="Scytalone_dh"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02982">
        <property type="entry name" value="Scytalone_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF024851">
        <property type="entry name" value="SCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Scytalone dehydratase-like" evidence="6">
        <location>
            <begin position="8"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR024851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR024851-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR024851-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4033162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="172" mass="19970" checksum="4A2C7AC9CADF61B8" modified="2024-10-02" version="1">MAGEKKQQITFEEYLGVTEAAFEWADSYDSKDWDRLRKCIAPTLRIDYRSFLNKLWEAMPAEEFMAMISDKSVLGNPLLRTQHFIGGASKWEKVSDTEIIGYHQLRVPHQVYTDASLEKVEVKGHAHSHNTHYYRKVNGVWKFAGLNPNIRWFEYDFDKVFAGGRDSFGEAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SN85</accession>
    <name>A0AAN6SN85_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_40061</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854527">
        <property type="protein sequence ID" value="KAK4033493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SN85"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4033493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="74" mass="8411" checksum="C620DEA553ACE076" modified="2024-10-02" version="1">MEKGGDWDEVVIPQELQDCASGTSKNDRYGTDPRLYDWCKWEEDLDAVEGFFEQELYAKFDPDAEGGGEGVRTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SNC4</accession>
    <name>A0AAN6SNC4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetylglucosaminylphosphatidylinositol deacetylase</fullName>
            <ecNumber evidence="2">3.5.1.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_19412</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PIGL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.89" evidence="2"/>
    <dbReference type="EMBL" id="MU854516">
        <property type="protein sequence ID" value="KAK4033672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SNC4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000225">
        <property type="term" value="F:N-acetylglucosaminylphosphatidylinositol deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="entry name" value="LmbE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993:SF11">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL DE-N-ACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL DE-N-ACETYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="LmbE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4033672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="298" mass="33412" checksum="BBFAB4E1095CC4CC" modified="2024-10-02" version="1">MQLLTKPAKMLGRVPRRAWRWILRATAVALVVPVLLQWVVAYLVGSDARILPPQLLAARNLLIVTAHPDDECLFFSPSILGVLDRNRAITGGLLVMSTGNNYGMGEARVEELQGSCRALGIHPERCIALDHPELQDNPKVWWNTDLIEGIVREHVSKWKVDAIVTFDEGGVSGHLNHRAVSAAVSHYAATNPEAPAAFTLTTTSLLRKYTFLGDLPLTALPFAWRIISALSYPAVTADPTAGTRALAANTWSRYRQTRHAFAQHPSQYTWDRHLYMIMSRYVWFNDLKRVERVAEKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SNH9</accession>
    <name>A0AAN6SNH9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Rab-GTPase-TBC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_39771</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854511">
        <property type="protein sequence ID" value="KAK4033763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SNH9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.750:FF:000003">
        <property type="entry name" value="GTPase activating protein (Evi5)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000027">
        <property type="entry name" value="GTPase activating protein (Evi5)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000001">
        <property type="entry name" value="TBC1 domain family member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="5">
        <location>
            <begin position="266"/>
            <end position="450"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
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            <begin position="179"/>
            <end position="230"/>
        </location>
    </feature>
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            <begin position="576"/>
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    </feature>
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            <begin position="721"/>
            <end position="752"/>
        </location>
    </feature>
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            <begin position="886"/>
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        </location>
    </feature>
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            <begin position="1035"/>
            <end position="1058"/>
        </location>
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            <begin position="677"/>
            <end position="704"/>
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        <location>
            <begin position="784"/>
            <end position="853"/>
        </location>
    </feature>
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        <location>
            <begin position="955"/>
            <end position="986"/>
        </location>
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        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
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            <begin position="85"/>
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        </location>
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        <location>
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        <location>
            <begin position="1037"/>
            <end position="1051"/>
        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
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        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK4033763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1058" mass="114758" checksum="DF002B06DF8AF9D5" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SNJ2</accession>
    <name>A0AAN6SNJ2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_38594</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF188">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="311"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="370"/>
        </location>
    </feature>
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        </location>
    </feature>
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            <end position="477"/>
        </location>
    </feature>
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            <end position="504"/>
        </location>
    </feature>
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            <end position="511"/>
        </location>
    </feature>
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            <end position="53"/>
        </location>
    </feature>
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            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
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            <end position="23"/>
        </location>
    </feature>
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        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4034961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="524" mass="57377" checksum="614775FC77FC5EB4" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SP10</accession>
    <name>A0AAN6SP10_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_18965</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854491">
        <property type="protein sequence ID" value="KAK4034185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SP10"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="F-box" evidence="4">
        <location>
            <begin position="50"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="155"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="253"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="541"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="581"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4034185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="787" mass="86290" checksum="8DC727E307404D41" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SP56</accession>
    <name>A0AAN6SP56_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcription factor PAP1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_39092</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the bZIP family. YAP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854480">
        <property type="protein sequence ID" value="KAK4034423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SP56"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000067">
        <property type="entry name" value="BZIP transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.100">
        <property type="entry name" value="YAP1 redox domain. Chain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050936">
        <property type="entry name" value="AP-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013910">
        <property type="entry name" value="TF_PAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023167">
        <property type="entry name" value="Yap1_redox_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621:SF6">
        <property type="entry name" value="AP-1-LIKE TRANSCRIPTION FACTOR YAP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08601">
        <property type="entry name" value="PAP1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111430">
        <property type="entry name" value="YAP1 redox domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="6">
        <location>
            <begin position="149"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="23"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="255"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="348"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="23"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="127"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="165"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="286"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="369"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="388"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4034423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="577" mass="63000" checksum="31C8818787BA37F6" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SQ99</accession>
    <name>A0AAN6SQ99_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_37946</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854439">
        <property type="protein sequence ID" value="KAK4038108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SQ99"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4038108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="245" mass="26977" checksum="E31AF76A745DA072" modified="2024-10-02" version="1">MSSPTPHKNSRPQHLHLPQPPPPQQPRQPIQPRQNLRQGPLPLPATPPPRPPKPHPTTTTTTTSGSNALVLTKAQRVCLWKGGWRAVPSDWRWVYDGSEAEWEGFRERLVDAVRRDGYKLEFVCLVGADYVRRGSAWLPWGDWGCGGIVVGEVGRSADFVAVAPTGGSSPGRVKLYRLMGCEDWEVVKEDMEAAYVRATDRVEWVAGALSIVSLDTLRRLLGQGTLAHLSGPDLFLRAPANLTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SQG9</accession>
    <name>A0AAN6SQG9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_37634</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854430">
        <property type="protein sequence ID" value="KAK4038391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SQG9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4038391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="185" mass="19922" checksum="F6A8D77A8DE9BDF6" modified="2024-10-02" version="1">MASTAAYPSTDHVVAAAKAVARALKDGGVKYAIVGGAACLLLGSNRVTTDVDFVTHADHFAVDSRTNHTVYLSNPPIEIQISAPPALFREPFDEDTETIEVLDGVHVLKPTLILNAKCRSILGRAGDDKKMSDAQDIRFLLNWCAEHDMATKADVPNATGEFVEAFIAMYGGEELWGNLGYDAEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SQS4</accession>
    <name>A0AAN6SQS4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_47361</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854409">
        <property type="protein sequence ID" value="KAK4039157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SQS4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="456"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="510"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="571"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="798"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="355"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="473"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="512"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="575"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="606"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="617"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="801"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="855"/>
            <end position="867"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4039157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="876" mass="95959" checksum="76F56C3B10A2A6B4" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SQY5</accession>
    <name>A0AAN6SQY5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_47618</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854418">
        <property type="protein sequence ID" value="KAK4038813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SQY5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013595">
        <property type="entry name" value="Pept_S33_TAP-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051601">
        <property type="entry name" value="Serine_prot/Carboxylest_S33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248">
        <property type="entry name" value="2-SUCCINYL-6-HYDROXY-2,4-CYCLOHEXADIENE-1-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248:SF25">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08386">
        <property type="entry name" value="Abhydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="189"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S33 tripeptidyl aminopeptidase-like C-terminal" evidence="5">
        <location>
            <begin position="547"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4038813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="682" mass="74282" checksum="54431F41BA83F179" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SR60</accession>
    <name>A0AAN6SR60_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 subunit M</fullName>
            <shortName evidence="5">eIF3m</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_36745</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CSN7/EIF3M family. CSN7 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-3 subunit M family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854405">
        <property type="protein sequence ID" value="KAK4039260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SR60"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03012">
        <property type="entry name" value="eIF3m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045237">
        <property type="entry name" value="COPS7/eIF3m"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027528">
        <property type="entry name" value="eIF3m"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 7/DENDRITIC CELL PROTEIN GA17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350:SF2">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="7">
        <location>
            <begin position="305"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="509"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="509"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4039260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="553" mass="62586" checksum="E592BDC23D1EA080" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SR75</accession>
    <name>A0AAN6SR75_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_47205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854404">
        <property type="protein sequence ID" value="KAK4039305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SR75"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42053">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42053:SF1">
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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            <end position="120"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="121"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4039305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="333" mass="34932" checksum="6CF06C7757CA44D0" modified="2024-10-02" version="1">MSTRPTLRVSTPLTANFPHIPPSASELQSAVSLPSAVSANTPLSAISRTSAFRDRDPFPSGLPSAGLPSAGPFSATIKLEQDLQKTPITPPVAYLDFLRGMSLVSPCLASPPQTGKSVLNRTSTASTTSSTSSARSNDSNTSSSSTETEDSEKEKSDQIESAPSTARSELSCECDEKDKEKTKGSKPAPIDTKKPVTPRGGPTCPMSAPPAGPTVFPSMKLPASPAITTAGLYSPRSPLSAASVRSPFDWEAALKSRRFAETPGSKRPAAPETPGIPATAGTPGTPGHSKRESRSSIRHIREVVTRTVTYTPRMAPAPKGKRRKIDPETAVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SR85</accession>
    <name>A0AAN6SR85_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-lactamase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_36702</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854403">
        <property type="protein sequence ID" value="KAK4039335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SR85"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36839">
        <property type="entry name" value="METALLO-BETA-LACTAMASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G12770)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36839:SF1">
        <property type="entry name" value="METALLO-BETA-LACTAMASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G12770)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="1">
        <location>
            <begin position="90"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4039335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="317" mass="35190" checksum="313C838F6DD956B3" modified="2024-10-02" version="1">MTDSITYLICNTCGTQHATPDRAALPTCFICDDPRQYTPPTGQSFTTLGALRAAGNHSNEFHPILPPTTTSNDATARFTSIVTTPQFAIGQRAILIRTPKGNVLWDCVTYLDDATAQRIETELGGIQAMVISHPHFYSAHLEWAERFGCKVYLAAEDKRWLARRDEARQVFVEGVEARVEGVGGEDTGVRVVKLGGHFPGSLVLLYEGHLFTADTLMMTPAGRGNWGVDALGNPRERPQGMNTFSFMWSIPNMIPLSADEIVRMWGILKNYNFRSAHGLCLGWDIEDENIKARVLESMQIQIRAMGHGQHPFLQEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SRC1</accession>
    <name>A0AAN6SRC1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_35748</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854381">
        <property type="protein sequence ID" value="KAK4040234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SRC1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35587:SF4">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35587">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="174"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4040234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="236" mass="27860" checksum="1D1EB736C4D481E8" modified="2024-10-02" version="1">MSSPQRKENEQLPKQEEDEQKPEQSTQAEQPQHHATAEDEDGEDNDNNIQQQNAGDEDEENYDEEDPQGENQRVLEDDYQSGDDQDQDQEEDEEEAADEEYPAQAQQQKENEDEHSPALSQPPTPKDGEKPQPKWMQKEKKPKQAQDQQLDRRRRRRRNRYSDDEDDDEDYDDQIAYQQQQRQQQMQMQQQQQQMQQQQGDGGKKNPLKLRLDLNLEIEIELKAHIHGDLTLALLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SRW9</accession>
    <name>A0AAN6SRW9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_35134</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854368">
        <property type="protein sequence ID" value="KAK4040864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SRW9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042959077" evidence="2">
        <location>
            <begin position="25"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4040864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="353" mass="37538" checksum="C92FAD5B46B176E7" modified="2024-10-02" version="1">MARTQGFRLTLRGCLLQLATLISASPLHSVARRDSTTTTTTWIAPTTVTVNPRDPTITREAGWTTTTGPPPFTSTITSSCITYDYSYPPADHPPSVTTQTVTARSTVTVTDTNRPLETQYSFHTPTVTATTPLATYVSYHCLNTLIVQYHSWEYLTWTWSNWEHTATTTGLCLTTSTRSTTIPGVTLPAPDSKSLEDWEYFSEPGQSVATKNSVAIVTDTSATIAGTTTRTVCDGRNPSPVTTTTITVTRQSTTTKTVTGGGQCTTVTGRAPEPRARSGAEGAGSGVEARQGGNTPVEVRTVVYTTVTVVSNMALTLTGTAVVDVNTQSFPVTRIAYVTRTGAGVVTATATVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SSR9</accession>
    <name>A0AAN6SSR9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_46057</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854372">
        <property type="protein sequence ID" value="KAK4040688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SSR9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000086">
        <property type="entry name" value="Acetyltransferase, GNAT family, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051016">
        <property type="entry name" value="Diverse_Substrate_AcTransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10545">
        <property type="entry name" value="DIAMINE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10545:SF29">
        <property type="entry name" value="GH14572P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="6"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="53"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="53"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4040688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="192" mass="21148" checksum="79D9534CCA59A299" modified="2024-10-02" version="1">MASNTPTVRHARREDVPAILDLIRELADYEHALDSVEATEAKLLETIAFAPSESSTTTSSSSSSNSSPLPQTEPTSPSKPARCLVLSTPAGAVAGIALYFYNYSTWRARPGIYLEDLYVKQSERKNGYGKRLLVELAKEVVAMQGGRLEWAVLKWNEPSIKFYESIGAQMMSEWVGMRVDGEGLNKLATMLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SSY8</accession>
    <name>A0AAN6SSY8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_15116</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854363">
        <property type="protein sequence ID" value="KAK4041150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SSY8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053185">
        <property type="entry name" value="SET_domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332:SF6">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043018430" description="SET domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="2">
        <location>
            <begin position="123"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4041150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="443" mass="49245" checksum="D371F83F4DB2CABB" modified="2024-10-02" version="1">MAWGQLSLTRVLLLGLLAPLAAADAEGTVKADPPPSGPGDGLAYDPIQKVDIYTDNATAHAPLTPPVQGWWDSKICSGAFCVYTNRRIAKGRGLVVVTKPEEFQKLERIEDHLNRGENKYLEDPVPFTTTQVLHKGRGTTATKPIRRGKPLTVWSPVLIVHKSLFDQVPKKKERTRLLEAAISFLPDPTRASFNMQRGGGNTNNPPRSVEAILLAHPHEIDLGYATHKQTEETHSKHYANYPEAAALQHDCRPNVATYLDGSFALRATVARRVQAGEELSVSYVDPFLPRDERAAWVRRHRGVEGGEGEVAGGCPCKACSPDGGLKGEKAVEGDKRLKEILRIRGELRNHDSKLVDFKMIERFLKLYEEERLHVRLAEAYELAAVNFNYLGDDKRAKKYAELAVQAGIVEGGVESNDVIAMRIMAKDVKGHYSYRYTLKRRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6ST66</accession>
    <name>A0AAN6ST66_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_15091</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854363">
        <property type="protein sequence ID" value="KAK4041123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6ST66"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053157">
        <property type="entry name" value="Sterol_Uptake_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784:SF4">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="11"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="47"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="68"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4041123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="411" mass="45111" checksum="D92F37B2AB46A968" modified="2024-10-02" version="1">MRRAHRKSRYGCKVCKQRHIKCDERRPACSNCMVGQRQCSYLLHGPTLQSQSQSPSPGHLTTTSSTGPPTPVPFPLTPSPKPGPLLENSGATPRPSTEPCLLGEGYSLMHLELFHHFNHKLHLALPGVAPFLELALGEAFGTPYLMDELLALAAAHKSTLASNEHDASAYRTDATQLQTRALSRLNAAQPDVSDENCLALFFFSAFLGQHVLFDVFCPPRPDLSVVLDKFTHCLSLHRGIRTIAWRMLPWVSEQLQSTLKLAPEDLGMGTGSGAAGTPGSGGQVGTECAALLELLRTKTQLPGPASQACRDAVDTLQQMFDSARADTNRRFVVIQEWPVRVAASYVDLLDQRRPEALVILAYYGVLLLQARDYWAVGDAGSYLIRSVSKHLGTYWADWLKWPNTILENSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SV22</accession>
    <name>A0AAN6SV22_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit OST2</fullName>
            <shortName evidence="8">Oligosaccharyl transferase subunit OST2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_32184</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Endoplasmic reticulum membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the DAD/OST2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854325">
        <property type="protein sequence ID" value="KAK4043657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SV22"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003038">
        <property type="entry name" value="DAD/Ost2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10705">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT DAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10705:SF0">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT DAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02109">
        <property type="entry name" value="DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005588">
        <property type="entry name" value="DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4043657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="169" mass="17724" checksum="6DB46C34D170E139" modified="2024-10-02" version="1">MAPKRGNAAAAQAAAARSVSPAPPKAAAPTPPTTTTTATTTATPPAVTPKTNTGPGGAQTWDRIVQNLLAHYLDTTPQRTKLLDAFMAFLVAVGALQFVYCVVAGNYPFNAFLSGFSATVGQFVLTASLRIQTTEANKGDFPAVSPERAFADYVVCSLILHFFCVNFIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SV97</accession>
    <name>A0AAN6SV97_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_32470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854328">
        <property type="protein sequence ID" value="KAK4043343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SV97"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000500">
        <property type="term" value="C:RNA polymerase I upstream activating factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000182">
        <property type="term" value="F:rDNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001181">
        <property type="term" value="F:RNA polymerase I general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042790">
        <property type="term" value="P:nucleolar large rRNA transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006361">
        <property type="term" value="P:transcription initiation at RNA polymerase I promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039601">
        <property type="entry name" value="Rrn5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28079">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28079:SF1">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="500"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="97"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="510"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="551"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4043343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="703" mass="77536" checksum="0A3642A979DFEB07" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SVB3</accession>
    <name>A0AAN6SVB3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb-like DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_32325</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854326">
        <property type="protein sequence ID" value="KAK4043595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SVB3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054505">
        <property type="entry name" value="Myb_DNA-bind_8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22980">
        <property type="entry name" value="Myb_DNA-bind_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like DNA-binding" evidence="2">
        <location>
            <begin position="8"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="272"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4043595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="454" mass="49110" checksum="F913802094B66E76" modified="2024-10-02" version="1">MSNNDNVMARFLFAILQQKCLKDIDWNQVAHNPILAQQITNGHAARMRYSRFKASMLGQEPQRRNRTSSNKNRVSKKKKDDSPKPKKEEDENVKSSGSGIGNIKTENTADAAIKAERRSITQPSQPPAPMTTTPTMMKTEPGLVNAYHHLHHPSILSAASPRIKNEHLPNMTPAVNNTPAMPEPSPFGILTTTPTTSSAASTPYIDSSHHRMQMRLLTPCSDSDGAVGTMPSTMQGFLAHSPPPGPELLHHSQHSQHHQQQQQQHYMVGAGSPPLSSTSAPSPYDFSQQQHCDPTATTTGAVSPSPWHSQHHHHHGHSHSHSQTQGTGAGPGASVMFASSPSAFGLGLGLGVGTAAGGGYGLDGAYNPFCGSDHHHHDHHSQQQQQQQQHLHHHHHHHGHGHDEDGHHVVDPLGLHVGGGGTSMFRERELELEMGGGGLGTPVKGEWEGEGFEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SVB6</accession>
    <name>A0AAN6SVB6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Synaptobrevin homolog YKT6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">C8A01DRAFT_13098</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the synaptobrevin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854328">
        <property type="protein sequence ID" value="KAK4043403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SVB6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14824">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.50:FF:000017">
        <property type="entry name" value="Synaptobrevin-like protein Sybl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000004">
        <property type="entry name" value="Vesicle-associated membrane protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010908">
        <property type="entry name" value="Longin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051097">
        <property type="entry name" value="Synaptobrevin-like_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21136">
        <property type="entry name" value="SNARE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21136:SF168">
        <property type="entry name" value="VESICLE-ASSOCIATED MEMBRANE PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13774">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01270">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50859">
        <property type="entry name" value="LONGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Longin" evidence="11">
        <location>
            <begin position="11"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="12">
        <location>
            <begin position="152"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK4043403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="237" mass="26146" checksum="77DF4BE1F7CF7035" modified="2024-10-02" version="1">MASSSTPATPLLYACIAHNSTILTECTTSATSQTSSLASLILPKIDHTTPQKLTYTHGTHHIHYIAASPSEYPPTQPTAGGLTYLVISDSSAINRRISFGFLVELRKRFLAQHPPSSTDFADLPNYGCAAFNTDMRALMVEYGTTAHGRDDAISNVQREIDDVRGIMTRNIEGLLERGERIDLLVDKTDRLGQGASEFRVRSRGLKRRMWWKNVKLMGLLGFVVVLILVTIVVSVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SVD7</accession>
    <name>A0AAN6SVD7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Spindle pole body component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_13017</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytoskeleton</location>
            <location evidence="5">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TUBGCP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854327">
        <property type="protein sequence ID" value="KAK4043463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SVD7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22572">
        <property type="entry name" value="GCP5_NTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059169">
        <property type="entry name" value="GCP5_N_ext"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032797">
        <property type="entry name" value="Mod21_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF33">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14609">
        <property type="entry name" value="GCP5-Mod21_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma-Tubulin ring complex non-core subunit mod21 N-terminal" evidence="8">
        <location>
            <begin position="62"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="9">
        <location>
            <begin position="227"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="7">
        <location>
            <begin position="537"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="153"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="797"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="161"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="797"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="807"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="820"/>
            <end position="830"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4043463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="898" mass="101172" checksum="6CCFF2C89D063D87" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SWP4</accession>
    <name>A0AAN6SWP4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_42467</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854316">
        <property type="protein sequence ID" value="KAK4044858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SWP4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032157">
        <property type="entry name" value="PAC4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16093">
        <property type="entry name" value="PAC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4044858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="146" mass="15804" checksum="5B7197C89675BED2" modified="2024-10-02" version="1">MDAPIQLSFALPRSLDTRIYLHLTVKAKAIMLFLTTASMEDAGSPTPLGSFVYALPDKYNPSQPLATPLCTVEPTLEFTTRLAKLLARKTQRPTYVGNSISFASTGLGGTVDEEMDAFKKVVEVTLAQLRPVIEPAQAPSDGVHPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P3M1</accession>
    <name>A0AAN6P3M1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_21615</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU855274">
        <property type="protein sequence ID" value="KAK4028542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P3M1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF9">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="32"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="65"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4028542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="115" mass="11707" checksum="58EA37C50667EC28" modified="2024-10-02" version="1" fragment="single">KTALHIAAERGNLRIVQLLLEHEVDVDMADASGRTALHYAARGAHAEVVTLLLAGGADSEARDGKGRSPLHVAADAECKIVVRLLAMDGADLNAAIGGADASMNSVGSIGEGNAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P413</accession>
    <name>A0AAN6P413_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uridine nucleosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_21423</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IUNH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854860">
        <property type="protein sequence ID" value="KAK4031336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P413"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008477">
        <property type="term" value="F:purine nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006152">
        <property type="term" value="P:purine nucleoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.245.10">
        <property type="entry name" value="Ribonucleoside hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001910">
        <property type="entry name" value="Inosine/uridine_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023186">
        <property type="entry name" value="IUNH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036452">
        <property type="entry name" value="Ribo_hydro-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12304">
        <property type="entry name" value="INOSINE-URIDINE PREFERRING NUCLEOSIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12304:SF4">
        <property type="entry name" value="URIDINE NUCLEOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01156">
        <property type="entry name" value="IU_nuc_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53590">
        <property type="entry name" value="Nucleoside hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inosine/uridine-preferring nucleoside hydrolase" evidence="4">
        <location>
            <begin position="1"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4031336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="348" mass="36038" checksum="701E0DEF314FD655" modified="2024-10-02" version="1" fragment="single">KTTRNATSILTAIGKASTIPVYIGAAHALTRPAMHAPTDIHGETGLDGTDLLPPPTAPPLTSPPAIDAAYAALKACAPGTAWVVATGAFTNAAALFLKYPDLVPHIKGLSLMGGAVGGGFTQAVLGEVDGVARVGNWTQFAEFNVLADPEAAAAIFGDKELAGKTTLIPLDVSHLVLTTEGVRDLLLYGREEVEKGDVEGGGGGGRGKKTTQLRVMLVELVMFFAKTYSDVFGITEGPPLHDPLAVAAVLTGVGDQHEIPFCDCDPAGEPGLAQRERFEVTVVTEGTYEDARAGAKTGAITARLLPPGEEGVRIPRSLDIPLFWKVLEECVSRADAANAAAEAGAVLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P486</accession>
    <name>A0AAN6P486_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Lipid phosphate phosphatase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_21314</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PA-phosphatase related phosphoesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854801">
        <property type="protein sequence ID" value="KAK4031459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P486"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046839">
        <property type="term" value="P:phospholipid dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043216">
        <property type="entry name" value="PAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165">
        <property type="entry name" value="LIPID PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165:SF84">
        <property type="entry name" value="PHOSPHATIDIC ACID PHOSPHATASE BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="8">
        <location>
            <begin position="130"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="338"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4031459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="399" mass="44006" checksum="0A0B14FA7454967B" modified="2024-10-02" version="1">MLPFHRRDARREPAAATTDKPPLQGGTMRQRLVPFVIDWVKVSWRDILTMAVLGAATLGIYRAPYAATRNFPITFDASGDIVYPQFAYPNRGWIISPSLSGVICTIIPIGIMALAQLRIRSFWDFNNAVLGLLYSLILSSLFQVIIKTLIGGFRPIFLDVCRPDPSLAQSHNATGLNGVGFHSVMYTSEVCTNPDKDAVKNAMTSFPSGHATTAFAAYVFLFLWMNAKLKVWANFHATFYWLAALLAPLLGATLMAACLTVDQAHNWYDVCMGVLIGTIVAFMVYRVSYAAVWDWRYNHIPLRHRQVFDYAALAPEVMERALFVRKLGWGRKKGRGGRRGVFGRGKPRVGSNASSATYARNGGASMEVPPAQGGVSYPNPATVRPNGTGQNYGRGEDMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P4G6</accession>
    <name>A0AAN6P4G6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_42118</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854817">
        <property type="protein sequence ID" value="KAK4031420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P4G6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23520">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G04000)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23520:SF5">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G04000)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="197"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="272"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="348"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="424"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="26"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="246"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4031420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="475" mass="50800" checksum="CB9A00C8BB90739F" modified="2024-10-02" version="1">MPSLHQLGRTALRESGLPSVSAAGRDAVLIILARSCRMFAYGASSLILALFFAELGFSDSRIGLFMSLTLAGDVVLSLLLTLVADRVGRRRTLLAGSVLMIASGTVFALCEDFWVLLVAAVVGVISATGGDFGPFRAIEESMVSELTTPVTRADVLVWYVTLASLGSSVGTEMSGRIIEGLRGREGWTLVHAYHGCFWLYAVMGLVNVGCAAMLSERCELKGMTGAKQGEGETERLLNGGQADAPAPDHGKEPKTRTSWVSQISRETLSIMAVLWFLLMVDSLADGMANMSLTTYYMDQKFHLPKSALGDIVSASYFLSALSNIFAGPLARYLGLVNTMVFTHIPSSAAVLVFPLAQTVPLTFALLLLRVGLNNMDQAPRTALIAAVVRPEERTAVMGITGMLRTLASTTGPSITGLLAGGNRFWIAFVVAGALRLAYDVGVFAMFINIRLYKHEAAEAAGEESPEESVSRQTEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P4P1</accession>
    <name>A0AAN6P4P1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_51321</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854727">
        <property type="protein sequence ID" value="KAK4031681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P4P1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF15">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="6">
        <location>
            <begin position="321"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="175"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4031681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="690" mass="77228" checksum="9D62D43C1F9A9AA6" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P541</accession>
    <name>A0AAN6P541_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_20937</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854677">
        <property type="protein sequence ID" value="KAK4031921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P541"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022190">
        <property type="entry name" value="DUF3716"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12511">
        <property type="entry name" value="DUF3716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="177"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4031921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="277" mass="30507" checksum="C37F06B774F76793" modified="2024-10-02" version="1">MHVTLHFRVHLYHLLERIYSPTPSSANTNPHPAALALYKLMFAHLPPPPERPGSLCMYLASHPVKQIPVVSVRFNLAKPQNVVSFLMQATGDAVPADKACDRCARNNGVFKHICVVVRNQSLLNITGGTCAACWYGRQGSKCTFRKGMPTLLRKTPNPAFPSRRPASGQRKQPDPPATALAPEPATAPLHPSYAAALASGAVVVTPTPVLGSNNSVSRPDNPSRDENARVWESRYGCMSTDSLLQAHEHLAEWKDDLTTRLLAMNRVLLERLREREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P5H1</accession>
    <name>A0AAN6P5H1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heterokaryon incompatibility protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_20891</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854668">
        <property type="protein sequence ID" value="KAK4031975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P5H1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF73">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G01020)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="87"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4031975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="703" mass="79516" checksum="C90B38BCC323CB71" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P6L0</accession>
    <name>A0AAN6P6L0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_21401</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854845">
        <property type="protein sequence ID" value="KAK4031358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P6L0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4031358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="335" mass="35620" checksum="B1885F495BCA81D9" modified="2024-10-02" version="1">MVLPTCFVNIPALPTALYSGALVAQPWFAYAPTHTNYFGATSCGLSSYVKPTPSTAYQPSSTAPCTLPPSVSGSTYSVTPVIYVPRTTSSTLTYAPYTCDAIPAASINKGNFKFACKGLRGKDVGYGLHTISWSLPTDAGSIQPVTFWARPPTSTPKYVVNTALARTTLVPVTSVTVHATRTETMTPVSYVRIPTATSTYTCFVTVTATPVASPPLRHNGNDTRTDSDPEIFVSDSVVAHDDGNGNGNNDDTTEPDTEIAAATPTIGRPDYTYPPYGVTTIYVKSFSTRTTTWFDTVYKTAPAITSTTSYLSYTVATVTVTRTPSVSQSTAVAIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P6N2</accession>
    <name>A0AAN6P6N2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">alpha-1,3-glucan synthase</fullName>
            <ecNumber evidence="2">2.4.1.183</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">C8A01DRAFT_40812</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[(1-&gt;3)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose = [(1-&gt;3)-alpha-D-glucosyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19749"/>
            <dbReference type="Rhea" id="RHEA-COMP:11150"/>
            <dbReference type="Rhea" id="RHEA-COMP:11151"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28100"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.183"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase group 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.183" evidence="2"/>
    <dbReference type="EMBL" id="MU854579">
        <property type="protein sequence ID" value="KAK4032749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047657">
        <property type="term" value="F:alpha-1,3-glucan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070600">
        <property type="term" value="P:fungal-type cell wall (1-&gt;3)-alpha-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11323">
        <property type="entry name" value="AmyAc_AGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03791">
        <property type="entry name" value="GT5_Glycogen_synthase_DULL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000058">
        <property type="entry name" value="Alpha-1,3-glucan synthase Ags1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000052">
        <property type="entry name" value="Alpha-1,3-glucan synthase Ags2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058659">
        <property type="entry name" value="Mok11-13/Ags1-like_CBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058656">
        <property type="entry name" value="Mok11-13/Ags1-like_GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058657">
        <property type="entry name" value="Mok11-13/Ags1-like_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058658">
        <property type="entry name" value="Mok11-13/Ags1-like_Ig_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058655">
        <property type="entry name" value="Mok11-14/Ags1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058654">
        <property type="entry name" value="Mok11-14/Ags1-like_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013534">
        <property type="entry name" value="Starch_synth_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47182:SF2">
        <property type="entry name" value="CELL WALL ALPHA-1,3-GLUCAN SYNTHASE AGS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47182">
        <property type="entry name" value="CELL WALL ALPHA-1,3-GLUCAN SYNTHASE AGS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26127">
        <property type="entry name" value="12TM_Mok13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26122">
        <property type="entry name" value="CBM_Mok13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26108">
        <property type="entry name" value="GH_Mok13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08323">
        <property type="entry name" value="Glyco_transf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26114">
        <property type="entry name" value="Ig_2_Mok13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26111">
        <property type="entry name" value="Ig_Mok13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042910035" description="alpha-1,3-glucan synthase" evidence="9">
        <location>
            <begin position="21"/>
            <end position="2313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1071"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1890"/>
            <end position="1910"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1922"/>
            <end position="1941"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1948"/>
            <end position="1966"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1986"/>
            <end position="2003"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2015"/>
            <end position="2036"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2056"/>
            <end position="2077"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2098"/>
            <end position="2116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2136"/>
            <end position="2155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2167"/>
            <end position="2192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2244"/>
            <end position="2262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2285"/>
            <end position="2305"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="10">
        <location>
            <begin position="66"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1122"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1652"/>
            <end position="1720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1694"/>
            <end position="1707"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK4032749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="2313" mass="258523" checksum="C18A510D4838F111" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P721</accession>
    <name>A0AAN6P721_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Fad binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_21223</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854755">
        <property type="protein sequence ID" value="KAK4031583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P721"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF19">
        <property type="entry name" value="BINDING MONOOXYGENASE, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="15"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4031583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="436" mass="47082" checksum="72FBF968E06018F8" modified="2024-10-02" version="1">MATSASSSDGATRGKVIVVGAGPVGLFVALRLAQAGITVDVMEKDATLSDAPRAAGYYGGTLVALARAKVLEKAVDRGFVSTGLCWRKPVADDGEGGKRYGDIIARLPFPYGDPNSVTGKVPSLMLPQSKLAKLFFDEAKATGLVTVHFNMALTAIQDDGNSVKATFTRAESGAQETYQASFLVGADGGKSSTRKLLNIPFKGHSWPERLLAIDCVFETPRTVESGFPTSFIIHPVHFGLVLPLERFEPGKRSAYRCAVAIDPRDSRSDEELTSKESVDDLLDKMLPGPRPINAEVLRVAPYRIHQLCASSFRRGRCVLAGDAAHLNNPFGGMGLSSGLLDAEALTDSLDLIINEGSPLSLLDTYSSERQRVFQIFTSPVSTMNKLRCAADPELANEDWLIRALNTNPSSLKEYGRHFYDTWRTNMRSLVAGVPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P7E9</accession>
    <name>A0AAN6P7E9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_19875</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854549">
        <property type="protein sequence ID" value="KAK4033139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P7E9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24359:SF37">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24359">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SBK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="236"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="597"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4033139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="631" mass="71371" checksum="4AD6D948CC46F132" modified="2024-10-02" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P885</accession>
    <name>A0AAN6P885_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FAD binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_49896</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854523">
        <property type="protein sequence ID" value="KAK4033549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P885"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF8">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21274">
        <property type="entry name" value="Rng_hyd_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="8"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4033549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="595" mass="66762" checksum="A0866C2012314733" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P8Y1</accession>
    <name>A0AAN6P8Y1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_19253</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854506">
        <property type="protein sequence ID" value="KAK4033865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P8Y1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050587">
        <property type="entry name" value="GNT1/Glycosyltrans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11183">
        <property type="entry name" value="GLYCOGENIN SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="104"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4033865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="367" mass="41160" checksum="6BD2EE5620FB35E0" modified="2024-10-02" version="1">MSTSEKVVDSDKIWACLITTDSYLPGLLTLAYSLRRVKSRYPLVALHTGSLPDETLRALAARHVPLQRVPYLCPGPPPRAVAVSDGDGKTNGDNNGNGNGNGNGTDNSNANTTTTTDSSTWYANDPRFRACFTKLAVFSLTGYTRVVLLDADMLVRQNMDELFELPLDGERRLFAATHACLCNPLHFRHYPPSWTPPHCAFTLQQQTDSCAAQTSGGPPSLGMGLLNGGLLVLHPDLTIYSEIVGYLHSDKATPATLPFADQSLLSELFRERWVALPYVYNALKTMRWAGVHGGLWRDEKVKNVHYILTPKPWEEVLEGREKEKVYQEAEEQGDETDRWWREVDLERRRWEVDRGFLSVREGKLDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P9G1</accession>
    <name>A0AAN6P9G1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dynein heavy chain, cytoplasmic</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Dynein heavy chain, cytosolic</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">C8A01DRAFT_39311</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Consists of at least two heavy chains and a number of intermediate and light chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein heavy chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854489">
        <property type="protein sequence ID" value="KAK4034216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003006">
        <property type="term" value="P:developmental process involved in reproduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007097">
        <property type="term" value="P:nuclear migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072384">
        <property type="term" value="P:organelle transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.20:FF:000002">
        <property type="entry name" value="Cytoplasmic dynein 1 heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000122">
        <property type="entry name" value="Cytoplasmic dynein 1 heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.2620:FF:000001">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.710:FF:000005">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.100:FF:000002">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.30:FF:000001">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.180.20:FF:000002">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000071">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000517">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.720:FF:000003">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.130:FF:000007">
        <property type="entry name" value="Dynein heavy chain, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.1220:FF:000004">
        <property type="entry name" value="Dynein heavy chain, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000075">
        <property type="entry name" value="Dynein heavy chain, cytoplasmic"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000829">
        <property type="entry name" value="Dynein heavy chain, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.100">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.20">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.720">
        <property type="entry name" value="Region D6 of dynein motor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035699">
        <property type="entry name" value="AAA_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035706">
        <property type="entry name" value="AAA_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041658">
        <property type="entry name" value="AAA_lid_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042219">
        <property type="entry name" value="AAA_lid_11_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054354">
        <property type="entry name" value="DYNC2H1-like_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042222">
        <property type="entry name" value="Dynein_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043157">
        <property type="entry name" value="Dynein_AAA1S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041466">
        <property type="entry name" value="Dynein_AAA5_ext"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024743">
        <property type="entry name" value="Dynein_HC_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024317">
        <property type="entry name" value="Dynein_heavy_chain_D4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004273">
        <property type="entry name" value="Dynein_heavy_D6_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013602">
        <property type="entry name" value="Dynein_heavy_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013594">
        <property type="entry name" value="Dynein_heavy_tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042228">
        <property type="entry name" value="Dynein_linker_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532:SF4">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532">
        <property type="entry name" value="MALE FERTILITY FACTOR KL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12774">
        <property type="entry name" value="AAA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12775">
        <property type="entry name" value="AAA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12780">
        <property type="entry name" value="AAA_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12781">
        <property type="entry name" value="AAA_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18198">
        <property type="entry name" value="AAA_lid_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08385">
        <property type="entry name" value="DHC_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08393">
        <property type="entry name" value="DHC_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22597">
        <property type="entry name" value="DYN_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17852">
        <property type="entry name" value="Dynein_AAA_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03028">
        <property type="entry name" value="Dynein_heavy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12777">
        <property type="entry name" value="MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0243">Dynein</keyword>
    <keyword evidence="6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="12" id="KW-0505">Motor protein</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="16">
        <location>
            <begin position="1913"/>
            <end position="2051"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="16">
        <location>
            <begin position="2570"/>
            <end position="2724"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="16">
        <location>
            <begin position="2912"/>
            <end position="3078"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="1631"/>
            <end position="1658"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="3160"/>
            <end position="3236"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="3400"/>
            <end position="3434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00033439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAK4034216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="4334" mass="490614" checksum="EE0094D9F74591D9" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P9T5</accession>
    <name>A0AAN6P9T5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_39145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854482">
        <property type="protein sequence ID" value="KAK4034368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P9T5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="83"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="106"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4034368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="131" mass="13711" checksum="E2E8B73AA2E827E2" modified="2024-10-02" version="1">MCHYKRIIAACGCRVGVLLARSCEHRNTPQCQCRHLLERIRLATNCRRHSSSVSASSPAQVAQASPGPSPIRRRGTPNRRNRSTSSSGNNRRSGSGFGLTIRRRSSSGSSSSGGNAGARSSSTGSGAGSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PA00</accession>
    <name>A0AAN6PA00_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sensitive to high expression protein 9, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">C8A01DRAFT_20009</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Required for the maintenance of the structure of the mitochondrial inner membrane. Involved in mitochondrial morphology. Causes growth arrest when highly overexpressed.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion inner membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the SHE9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854559">
        <property type="protein sequence ID" value="KAK4032993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PA00"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007007">
        <property type="term" value="P:inner mitochondrial membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008839">
        <property type="entry name" value="MDM33_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31961">
        <property type="entry name" value="SENSITIVE TO HIGH EXPRESSION PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31961:SF3">
        <property type="entry name" value="SENSITIVE TO HIGH EXPRESSION PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05546">
        <property type="entry name" value="She9_MDM33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="467"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="50"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="61"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="74"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="111"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK4032993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="493" mass="53719" checksum="22648176CF63E354" modified="2024-10-02" version="1">MSAHTAFRLAARPIQRASFLPQLAAAAAQKRLSHRPQICLRCSIAVRLGTGPGRTRLFSTSPPPPRQPPPWQPGPEDGSTTPEPESTTPKDASSTAASPSSPAEQSEQHPQPEPAPTTPPCEPPSPEPTAEPDSTPPQPDQTAQTELPSQQDPSLPSFTETHRHPLSARFSTFMDNLQSRAVTATQTLNDLTGYSAIEAIKSRNTQLETEHAASQTRLRAARHDYKALTSHRAATQREVTTLLARKDTWNPTDLERFTTLYRLDHELETHVAAAAAELTDAETDEARLSGELNAGILKRYHEEQIWSDRIRRQSTWGTWGLMGVNILLFLVLQFVAEPWRRRRLVNGIAESEKGVMEEVRRELGAVKAALEASGLREREAAAVAAAAAEAAALASAPVEEVAFDGSGEGAAVASPEIVALTEAEQWDVPRKAWREVLAEFWEDPELLREAVLDLSSDRRVDLRMRDASLIALQGAAAGATVAVVLAFSLLRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PA33</accession>
    <name>A0AAN6PA33_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SprT-like family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_18681</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854476">
        <property type="protein sequence ID" value="KAK4034534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PA33"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00084">
        <property type="entry name" value="HMG-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006640">
        <property type="entry name" value="SprT-like_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035240">
        <property type="entry name" value="SprT_Zn_ribbon"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23099:SF0">
        <property type="entry name" value="GERM CELL NUCLEAR ACIDIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23099">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10263">
        <property type="entry name" value="SprT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17283">
        <property type="entry name" value="Zn_ribbon_SprT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00731">
        <property type="entry name" value="SprT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SprT-like" evidence="2">
        <location>
            <begin position="383"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="553"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4034534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="641" mass="71486" checksum="5FBCCECAEF56B8E6" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PA52</accession>
    <name>A0AAN6PA52_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_38956</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854474">
        <property type="protein sequence ID" value="KAK4034564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PA52"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000180">
        <property type="entry name" value="MFS monosaccharide transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF61">
        <property type="entry name" value="HIGH AFFINITY GLUCOSE TRANSPORTER RGT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="88"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="374"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="406"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="450"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="478"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="29"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4034564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="550" mass="59696" checksum="6A1B809F73C7A4E8" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PB44</accession>
    <name>A0AAN6PB44_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_40810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854579">
        <property type="protein sequence ID" value="KAK4032747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PB44"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="147"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="248"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4032747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="383" mass="41374" checksum="10D80D0ED5C937C3" modified="2024-10-02" version="1">MAKAKYNKHRRAKFRAAAAQAAQAARDAEVEAAASAATNIEQGTSMDVDPAPLAKSSATLLQSAGTATIADTHVQGLKYAQRGESEVEGLDMREVAAALEAAMDDTSEQNLEALIRAVDFDVLKLANLALDNSNMHTSATILLSTAIMMSENKATQAEKKAIEAENKATEAETKAAEAGNKASEAQYEAITAQTNCDGVLARNLENAHALLGQGSHLAQIERRLSALERLPPTPTSSSANNNSDGDTIAALKRMLAITNAQLQAITQDHDKLRETVNKALLTTAAASGPEGTMDDLVGRMQVLADMRREAEQNEFERKDYLRQQEVRGLRDEIALLRKERQETSVLASQFRKMRAYLIAFVGGELTDHELIERLRGHNVAGVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PBI2</accession>
    <name>A0AAN6PBI2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial carrier domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">C8A01DRAFT_38201</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854447">
        <property type="protein sequence ID" value="KAK4035356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PBI2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071913">
        <property type="term" value="F:citrate secondary active transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006843">
        <property type="term" value="P:mitochondrial citrate transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000092">
        <property type="entry name" value="Mitochondrial tricarboxylate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000064">
        <property type="entry name" value="Mitochondrial tricarboxylate transporter (Ctp)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049563">
        <property type="entry name" value="TXTP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788">
        <property type="entry name" value="SUCCINATE/FUMARATE MITOCHONDRIAL TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788:SF4">
        <property type="entry name" value="TRICARBOXYLATE TRANSPORT PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="17"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="107"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="204"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK4035356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="301" mass="32465" checksum="42AFD92F45EEB5A6" modified="2024-10-02" version="1">MSSAPAKEDAHPAVKGPSALRSILAGSTAGAVEIAITYPAEFAKTRTQLNRRLAAGQKLPWPPFGKQWYAGCTTLIIGNSAKAGIRFVAFDQYRKLLADADGKMSGPRTVLAGFGAGVTESLLAVTPTESIKTTLIDDRKSANPRLRGFLHAVPIIARERGIRGFFQGFVPTTARQAANSATRFGSYTALKQLAEGYTAPGEKLGAAATFAMGGVAGLITVYVTQPLDTIKTRMQSIEARALYGNSFRCAGIIFRQEGVLTFWSGALPRLARLIMSGGIVFTMYEKSMEMFDRLDPERRYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PBW8</accession>
    <name>A0AAN6PBW8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Six-hairpin glycosidase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_39003</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 88 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854476">
        <property type="protein sequence ID" value="KAK4034522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PBW8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052757">
        <property type="term" value="F:chondroitin hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000048">
        <property type="entry name" value="Unsaturated chondroitin disaccharide hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052369">
        <property type="entry name" value="UG_Glycosaminoglycan_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36845">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G05090)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36845:SF1">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G05090)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4034522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="566" mass="61444" checksum="996F3783EEC844E5" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PC96</accession>
    <name>A0AAN6PC96_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetyltransferase B complex non catalytic subunit-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_39391</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MDM20/NAA25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854493">
        <property type="protein sequence ID" value="KAK4034133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PC96"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031416">
        <property type="term" value="C:NatB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019183">
        <property type="entry name" value="NAA25_NatB_aux_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767:SF3">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 25, NATB AUXILIARY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767">
        <property type="entry name" value="N-TERMINAL ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09797">
        <property type="entry name" value="NatB_MDM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4034133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1015" mass="112819" checksum="03F2DF1976AE8474" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PCD5</accession>
    <name>A0AAN6PCD5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">2,3-bisphosphoglycerate-independent phosphoglycerate mutase</fullName>
            <ecNumber evidence="6">5.4.2.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Cofactor-independent phosphoglycerate mutase homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">C8A01DRAFT_37748</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate</text>
            <dbReference type="Rhea" id="RHEA:15901"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="EC" id="5.4.2.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BPG-independent phosphoglycerate mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.12" evidence="6"/>
    <dbReference type="EMBL" id="MU854433">
        <property type="protein sequence ID" value="KAK4038291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PCD5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004619">
        <property type="term" value="F:phosphoglycerate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006007">
        <property type="term" value="P:glucose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16010">
        <property type="entry name" value="iPGM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1450.10:FF:000001">
        <property type="entry name" value="2,3-bisphosphoglycerate-independent phosphoglycerate mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1450.10">
        <property type="entry name" value="BPG-independent phosphoglycerate mutase, domain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01038">
        <property type="entry name" value="GpmI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011258">
        <property type="entry name" value="BPG-indep_PGM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006124">
        <property type="entry name" value="Metalloenzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036646">
        <property type="entry name" value="PGAM_B_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005995">
        <property type="entry name" value="Pgm_bpd_ind"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01307">
        <property type="entry name" value="pgm_bpd_ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31637">
        <property type="entry name" value="2,3-BISPHOSPHOGLYCERATE-INDEPENDENT PHOSPHOGLYCERATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31637:SF0">
        <property type="entry name" value="2,3-BISPHOSPHOGLYCERATE-INDEPENDENT PHOSPHOGLYCERATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06415">
        <property type="entry name" value="iPGM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01676">
        <property type="entry name" value="Metalloenzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001492">
        <property type="entry name" value="IPGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64158">
        <property type="entry name" value="2,3-Bisphosphoglycerate-independent phosphoglycerate mutase, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9 15" id="KW-0464">Manganese</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metalloenzyme" evidence="16">
        <location>
            <begin position="6"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="BPG-independent PGAM N-terminal" evidence="17">
        <location>
            <begin position="87"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="13">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="158"/>
            <end position="159"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="262"/>
            <end position="265"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="407"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="411"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="448"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="466"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00071648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00083354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001492-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001492-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001492-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF06415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAK4038291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="519" mass="56555" checksum="58C56ACB6D2385AD" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PCH5</accession>
    <name>A0AAN6PCH5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Signal sequence receptor subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">C8A01DRAFT_39694</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Is probably involved in a pathway contributing to genomic integrity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the IRC22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854507">
        <property type="protein sequence ID" value="KAK4033846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PCH5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005595">
        <property type="entry name" value="TRAP_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12924:SF0">
        <property type="entry name" value="TRANSLOCON-ASSOCIATED PROTEIN SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12924">
        <property type="entry name" value="TRANSLOCON-ASSOCIATED PROTEIN, ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03896">
        <property type="entry name" value="TRAP_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0732">Signal</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042981228" description="Signal sequence receptor subunit alpha" evidence="11">
        <location>
            <begin position="22"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="203"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="246"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK4033846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="264" mass="28173" checksum="EB9B87D98217ADFC" modified="2024-10-02" version="1">MVNFKWSSLALLALRAATAFAADDVDAEPVTAVPVEQPELKADIETTFPDADIFGVKIVNGRVTKALIEITNHEDSPIDVSFVGGMLKTTQPLPDDAPASAAILRNLTAVRYDVSIPPGEKHQLPFQFVLDMMPQDVLVELVAIISNAASNQVFQVQAHSGAASIVDIFLYLFLSGIFGATLYFVYKTWIEALFPQAKAKAAPSGGKKAARKPVVEAEPLSGSESAGATSGGDGRSYDESWIPTHHINRPVARRVKSGASGKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PDG3</accession>
    <name>A0AAN6PDG3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_16987</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854414">
        <property type="protein sequence ID" value="KAK4038949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PDG3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4038949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="254" mass="30508" checksum="B936651883FF3419" modified="2024-10-02" version="1">MLWQRLKALFIYLWNFRYLPLKYRWPLIKFRRRLLPTRTGLGLRNALRHARSLKHPPEPRPYLFVLRLLWPFPAWRFPAVLPPPPRVIMADPESVRCRVRDLMYLRSMPLWRARDTPQRAFYRLYEALCAADGRMITYETEYFWRQSSPRWAAADIPDPECDDPEQYAVMASLAEVLVESFVWRLELGLRRNDKPIMDRAVDPPPVAPEMYPTWTAKVPPLKEKLVMHPEEDEYFDSPLHRRNIYMSTGWFYTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PDJ9</accession>
    <name>A0AAN6PDJ9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_39148</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854482">
        <property type="protein sequence ID" value="KAK4034371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PDJ9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40788:SF2">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40788">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4034371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="485" mass="55708" checksum="D5EAE9426A07DEC0" modified="2024-10-02" version="1">MSTEPETPWARAIFRQESLEEGTDWLRYYADPVFRENMTDRGIGDHFQEWTQADKLAYAFLLQALEEMQASEAAQGRKQAGLGKPRAVAAGFGLSYEPRDPTATAVQITNNREDVQTTFIELQRTLGKFEFLIRKRWGKKKKLAERTKALQKAWPNMPASHRPDLHSIIEDRQQPREVFLMPYINLKDLVSGNTLLRLLNSRGRHEPCVFAQVDLERLQLATRSKKILQPYQLVVHKMDMSSSVLPPDALYGYVSLPTPRDARDVVIHREVAGSEGVLVLEVQARLLNFLTDFCREILHDKRAEIDDERIPEEPEPDPLPAHDETTDSIVWVALQAPYRTPHAAIDLHGMVDLAKAAADDAQMRLWTLRQDPGYFATAVVDFEQHSFEYILDVNRQHHADVDLPGKFFINKAVRKMVHEALRIALLWEVVASLLEQIVEQERRFLESAVQLEEDSPEYFDLLLRLRHTLDNMMLPDTMLRLASSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PE22</accession>
    <name>A0AAN6PE22_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9 11">Alpha-glucuronidase</fullName>
            <ecNumber evidence="2 9 11">3.2.1.139</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">aguA</name>
        <name evidence="16" type="ORF">C8A01DRAFT_36879</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Alpha-glucuronidase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose. Releases 4-O-methylglucuronic acid from xylan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9 11">
            <text>an alpha-D-glucuronoside + H2O = D-glucuronate + an alcohol</text>
            <dbReference type="Rhea" id="RHEA:20005"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:58720"/>
            <dbReference type="ChEBI" id="CHEBI:58899"/>
            <dbReference type="EC" id="3.2.1.139"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9 11">Belongs to the glycosyl hydrolase 67 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.139" evidence="2 9 11"/>
    <dbReference type="EMBL" id="MU854408">
        <property type="protein sequence ID" value="KAK4039191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PE22"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046559">
        <property type="term" value="F:alpha-glucuronidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02795">
        <property type="entry name" value="CBM6-CBM35-CBM36_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1330.10:FF:000001">
        <property type="entry name" value="Xylan alpha-1,2-glucuronidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1330.10">
        <property type="entry name" value="Alpha-glucuronidase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="entry name" value="Chitobiase/beta-hexosaminidase domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037054">
        <property type="entry name" value="A-glucoronidase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011395">
        <property type="entry name" value="Glyco_hydro_67_aGlcAse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005154">
        <property type="entry name" value="Glyco_hydro_67_aGlcAse_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011099">
        <property type="entry name" value="Glyco_hydro_67_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011100">
        <property type="entry name" value="Glyco_hydro_67_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39207">
        <property type="entry name" value="ALPHA-GLUCURONIDASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39207:SF1">
        <property type="entry name" value="ALPHA-GLUCURONIDASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07477">
        <property type="entry name" value="Glyco_hydro_67C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07488">
        <property type="entry name" value="Glyco_hydro_67M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03648">
        <property type="entry name" value="Glyco_hydro_67N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029900">
        <property type="entry name" value="Alpha-glucuronds"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="beta-N-acetylhexosaminidase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6 9 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="3 9 11" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042829946" description="Alpha-glucuronidase" evidence="12">
        <location>
            <begin position="16"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha glucuronidase N-terminal" evidence="13">
        <location>
            <begin position="21"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 67 catalytic" evidence="15">
        <location>
            <begin position="150"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 67 C-terminal" evidence="14">
        <location>
            <begin position="478"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="307"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="388"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR029900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR029900-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK4039191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="849" mass="93360" checksum="2DD4767762BF2F6C" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PE50</accession>
    <name>A0AAN6PE50_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Splicing factor U2AF subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">U2 snRNP auxiliary factor large subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">C8A01DRAFT_47208</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Necessary for the splicing of pre-mRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the splicing factor SR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854404">
        <property type="protein sequence ID" value="KAK4039309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PE50"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12231">
        <property type="entry name" value="RRM2_U2AF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12232">
        <property type="entry name" value="RRM3_U2AF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000097">
        <property type="entry name" value="U2 snRNP auxiliary factor large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006529">
        <property type="entry name" value="U2AF_lg"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01642">
        <property type="entry name" value="U2AF_lg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23139">
        <property type="entry name" value="RNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 7 8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="245"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="367"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="474"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="10"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="71"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK4039309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="573" mass="63854" checksum="1D2E3FA8DD9F5F80" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PEP4</accession>
    <name>A0AAN6PEP4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_46930</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854396">
        <property type="protein sequence ID" value="KAK4039594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PEP4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF5">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="3">
        <location>
            <begin position="114"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="632"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="753"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="638"/>
            <end position="653"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4039594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1040" mass="116192" checksum="5A9EA5280CB03332" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PES5</accession>
    <name>A0AAN6PES5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nipped-B-like protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_47209</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854404">
        <property type="protein sequence ID" value="KAK4039312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PES5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051865">
        <property type="term" value="P:protein autoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019193">
        <property type="entry name" value="UBQ-conj_enz_E2-bd_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31531:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE E3D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31531">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE E3D FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09814">
        <property type="entry name" value="HECT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4039312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="413" mass="44356" checksum="94AC3B61C52D16CA" modified="2024-10-02" version="1">MTSGDCDLYAELLANIRQISLAASLPSPCDASTQVAVLADGKSVELRHGSASRLLTLPAKTSLGRTLLPIQDKQRGSTLLAWRLPLDTSSLSPSQHADQMPWSATDLDPESGVACRQCAADVVHAGSIKAWKDLPSENWAEMMEFWHCHKPDHHHGHDEEPGKAGEESLAARGYGASSAISAQAGVGFVDLTTLIFDETDCQNVTFSLSTSDQGAADRLSLALTDSTTNQTRNLNVFCSSCHLQLGFFNFRTSAVRLLKWQVSCKSASAAVPGIPECLAATLISTISRSASSKSLITPITETVQGGGGNAGLEDAIHIWVLNSSIVYSSSGTPQRAPAIKLLYRPLPGAEADRMLESVTCDSQEISLPAQALSEVTRHLEESNALLPPTERIFKEWKVGLLTRWEREVCTSGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PEU3</accession>
    <name>A0AAN6PEU3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">C8A01DRAFT_16667</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854403">
        <property type="protein sequence ID" value="KAK4039342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PEU3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008598">
        <property type="entry name" value="Di19_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051061">
        <property type="entry name" value="Zinc_finger_trans_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179:SF13">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05605">
        <property type="entry name" value="zf-Di19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="574"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="607"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="637"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="451"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="470"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK4039342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="661" mass="75123" checksum="9841BB5511E35F7A" modified="2024-10-02" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PFH1</accession>
    <name>A0AAN6PFH1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Replication protein A subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">C8A01DRAFT_48301</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">As part of the replication protein A (RPA/RP-A), a single-stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the heterotrimeric canonical replication protein A complex (RPA).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the replication factor A protein 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854442">
        <property type="protein sequence ID" value="KAK4038009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PFH1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005662">
        <property type="term" value="C:DNA replication factor A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007004">
        <property type="term" value="P:telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04474">
        <property type="entry name" value="RPA1_DBD_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04475">
        <property type="entry name" value="RPA1_DBD_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04476">
        <property type="entry name" value="RPA1_DBD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04477">
        <property type="entry name" value="RPA1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000041">
        <property type="entry name" value="Replication protein A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000064">
        <property type="entry name" value="Replication protein A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000090">
        <property type="entry name" value="Replication protein A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000117">
        <property type="entry name" value="Replication protein A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055089">
        <property type="entry name" value="COP9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047192">
        <property type="entry name" value="Euk_RPA1_DBD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013955">
        <property type="entry name" value="Rep_factor-A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007199">
        <property type="entry name" value="Rep_factor-A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031657">
        <property type="entry name" value="REPA_OB_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004591">
        <property type="entry name" value="Rfa1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00617">
        <property type="entry name" value="rpa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47165">
        <property type="entry name" value="OS03G0429900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47165:SF4">
        <property type="entry name" value="OS03G0429900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22788">
        <property type="entry name" value="COP9_hel_rpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04057">
        <property type="entry name" value="Rep-A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08646">
        <property type="entry name" value="Rep_fac-A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16900">
        <property type="entry name" value="REPA_OB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PCI" evidence="11">
        <location>
            <begin position="875"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="113"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="151"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK4038009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1132" mass="125010" checksum="968A2F30B9C33519" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PFH3</accession>
    <name>A0AAN6PFH3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_37061</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854413">
        <property type="protein sequence ID" value="KAK4039015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PFH3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF9">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="9"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4039015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="92" mass="9506" checksum="273689747C59BE08" modified="2024-10-02" version="1">MGRAATIFSAVFLAIGGFLFGYDSGIIGSTIALPTFVEYFGKPSDTTVGGIVSAFQGSAILGTIINMFVADLLGRCRTIFAGATVSYLRAAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PFP0</accession>
    <name>A0AAN6PFP0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_35918</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854385">
        <property type="protein sequence ID" value="KAK4040046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PFP0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39605">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39605:SF1">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4040046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="180" mass="18773" checksum="A26F05DD39ABB7E0" modified="2024-10-02" version="1">MDSVSTYSVASLAWLATQAVPLIIWPSLISTLLQVDGPPPQGPQYGAANASLEQYFARSLGLAQLALGALLLVLSGALPLNSAADAPDTSAPTPSASAAVLVSALYHAATASYAYARYHTTGGQMAYLLGCLGGSVLAVFGLWVLMFAGDGKRRVSRRTGADKSTSGWPFKNVEAEKKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PFV3</accession>
    <name>A0AAN6PFV3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_46470</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="MU854383">
        <property type="protein sequence ID" value="KAK4040151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PFV3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4040151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="300" mass="33210" checksum="B9F03709528BAC81" modified="2024-10-02" version="1">MATTTTDADMFSQEVARLRAEYQAKRQQSNAFPPAGRPILDMELAPGDKPAVGIWYEDGTKLGQYVRLFDIPGTLWGDILGLERPLPAVKGHYEIEGDVIRSLDKCPNHPTEPEDDFEDVSDLTAKLPLIDVDSSKHFTKKGKYRSEIENLLKCQGGSCPGALLSPHLLILHIIDALSCLHALGIVHRDLRIDNCLFTPDGSRLVVCDLESRWGQRAAPEVAFDGGVDDSGWTTRSDVYDIGNCIKCMVYANAPITNQVEWPVTEPLQAVVEACMRKSPDDRPSLLELREMVEAIPVDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PGB7</accession>
    <name>A0AAN6PGB7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_15692</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854377">
        <property type="protein sequence ID" value="KAK4040443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PGB7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF562">
        <property type="entry name" value="ALDEHYDE REDUCTASE II (AFU_ORTHOLOGUE AFUA_1G11360)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="15"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4040443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="306" mass="33442" checksum="E089232431DC9BB5" modified="2024-10-02" version="1">MSPISNPVLLPGSRVLVTGVSGFLGSHIADQLLAGGYLVTGTTRDASKAAWVQRLFDSKYGERKFEIVEVPDIGFAGAFDKLLDGISGIVHAASDLTMDPNPEKVITPMVTGVLNMLNAAAQQPSIKRFVLTSSCTAAASQKPGVGQTIDANTWNDEVSREAWAPPPYGPERGFAVYAASKMEMEREAWKWHAEHKPHFVLNTDFFVDVQDSARLHFAALTHPGVQSERIFAYSAPFTWRGVQRAVQRLYPDKSFPRDIEEAELDTSVIVPAPRAEALLKDMGRPGWTILDETARMNTEDLASGAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PGJ5</accession>
    <name>A0AAN6PGJ5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_35426</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854374">
        <property type="protein sequence ID" value="KAK4040563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PGJ5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4040563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="102" mass="11559" checksum="77E1500AB6E9ACC9" modified="2024-10-02" version="1">MPANPERCDYFLRFSSKVSGGLTQCTEPYIRSVHLIAEKYFGVRAHWWHELNDLDEDPRKWMGCYGWSEVNEADRKLEALGTGQEQGGQSGNDGDGQTQSMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PGV4</accession>
    <name>A0AAN6PGV4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Alpha-galactosidase</fullName>
            <ecNumber evidence="3 7">3.2.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Melibiase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_35549</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="3 7"/>
    <dbReference type="EMBL" id="MU854377">
        <property type="protein sequence ID" value="KAK4040407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PGV4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04081">
        <property type="entry name" value="CBM35_galactosidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14792">
        <property type="entry name" value="GH27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000197">
        <property type="entry name" value="Alpha-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005084">
        <property type="entry name" value="CBM6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002241">
        <property type="entry name" value="Glyco_hydro_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041233">
        <property type="entry name" value="Melibiase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452:SF75">
        <property type="entry name" value="ALPHA-GALACTOSIDASE MEL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452">
        <property type="entry name" value="ALPHA-GALACTOSIDASE/ALPHA-N-ACETYLGALACTOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16499">
        <property type="entry name" value="Melibiase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17801">
        <property type="entry name" value="Melibiase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00740">
        <property type="entry name" value="GLHYDRLASE27"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51175">
        <property type="entry name" value="CBM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042873857" description="Alpha-galactosidase" evidence="8">
        <location>
            <begin position="19"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="domain" description="CBM6" evidence="9">
        <location>
            <begin position="404"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4040407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="541" mass="58077" checksum="E805B9726C2E1964" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PHB9</accession>
    <name>A0AAN6PHB9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">mRNA-capping enzyme subunit alpha</fullName>
            <ecNumber evidence="5">2.7.7.50</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">GTP--RNA guanylyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">mRNA guanylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="28" type="ORF">C8A01DRAFT_47288</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="29" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="29">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="24">Second step of mRNA capping. Transfer of the GMP moiety of GTP to the 5'-end of RNA via an enzyme-GMP covalent reaction intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>a 5'-end diphospho-ribonucleoside in mRNA + GTP + H(+) = a 5'-end (5'-triphosphoguanosine)-ribonucleoside in mRNA + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:67012"/>
            <dbReference type="Rhea" id="RHEA-COMP:17165"/>
            <dbReference type="Rhea" id="RHEA-COMP:17166"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:167616"/>
            <dbReference type="ChEBI" id="CHEBI:167617"/>
            <dbReference type="EC" id="2.7.7.50"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:67013"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="23">Heterodimer. The mRNA-capping enzyme is composed of two separate chains alpha and beta, respectively a mRNA guanylyltransferase and an mRNA 5'-triphosphate monophosphatase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic GTase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the sorting nexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="28">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.50" evidence="5"/>
    <dbReference type="EMBL" id="MU854407">
        <property type="protein sequence ID" value="KAK4039211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PHB9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004484">
        <property type="term" value="F:mRNA guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07895">
        <property type="entry name" value="Adenylation_mRNA_capping"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06867">
        <property type="entry name" value="PX_SNX41_42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000275">
        <property type="entry name" value="mRNA-capping enzyme subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.30:FF:000011">
        <property type="entry name" value="mRNA-capping enzyme subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001339">
        <property type="entry name" value="mRNA_cap_enzyme_adenylation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013846">
        <property type="entry name" value="mRNA_cap_enzyme_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
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        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044106">
        <property type="entry name" value="PX_Snx41/Atg20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051079">
        <property type="entry name" value="Sorting_Nexin_Autophagy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015404">
        <property type="entry name" value="Vps5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46979">
        <property type="entry name" value="SORTING NEXIN-41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46979:SF2">
        <property type="entry name" value="SORTING NEXIN-41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03919">
        <property type="entry name" value="mRNA_cap_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01331">
        <property type="entry name" value="mRNA_cap_enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09325">
        <property type="entry name" value="Vps5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0072">Autophagy</keyword>
    <keyword evidence="12" id="KW-0967">Endosome</keyword>
    <keyword evidence="17" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="16" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="18" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0506">mRNA capping</keyword>
    <keyword evidence="8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="19" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-0653">Protein transport</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="27">
        <location>
            <begin position="102"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-dependent DNA ligase family profile" evidence="26">
        <location>
            <begin position="743"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="442"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="25">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="25">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="25">
        <location>
            <begin position="444"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="25">
        <location>
            <begin position="458"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00029909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00030702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00044624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00047082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00053845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="KAK4039211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1005" mass="113914" checksum="14342FC2350AF909" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PHD5</accession>
    <name>A0AAN6PHD5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">vesicle-fusing ATPase</fullName>
            <ecNumber evidence="3">3.6.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">C8A01DRAFT_46507</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.6" evidence="3"/>
    <dbReference type="EMBL" id="MU854384">
        <property type="protein sequence ID" value="KAK4040108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PHD5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045324">
        <property type="term" value="P:late endosome to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02678">
        <property type="entry name" value="MIT_VPS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19521">
        <property type="entry name" value="RecA-like_VPS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.80:FF:000004">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000043">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000015">
        <property type="entry name" value="vacuolar protein sorting-associated protein 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007330">
        <property type="entry name" value="MIT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036181">
        <property type="entry name" value="MIT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050304">
        <property type="entry name" value="MT-severing_AAA_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015415">
        <property type="entry name" value="Spast_Vps4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045253">
        <property type="entry name" value="VPS4_MIT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074:SF83">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04212">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09336">
        <property type="entry name" value="Vps4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00745">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116846">
        <property type="entry name" value="MIT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="7 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MIT" evidence="15">
        <location>
            <begin position="3"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="171"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="77"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="419"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="425"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK4040108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="441" mass="48549" checksum="88139916E8D0D3D9" modified="2024-10-02" version="1">MSNTDFLDRAIKQVRIAIDADNAGQYDKAYTLYYQSLELFMLALKWEKNPKSKEMIRAKTGEYMDRAEKLKAHLSDAEGKRKKPGMVGANGASTGGTGKGKEAGEDGGGGGETLDEDSKKLRNALAGAILQERPNVSWDDVAGLEGAKEALKEAVLLPIKFPHLFQGKRQPWKGILLYGPPGTGKSYLAKAVATEAKSTFFSVSSSDLVSKWMGESERLVRQLFAMARENKPSIIFIDEIDALCGPRGEGESEASRRIKTEMLVQMDGVGKDSKGVLILGATNIPWQLDAAIRRRFQRRVHISLPDMAARTTMFKLAVGDTNTALKSEDFRELAKAAEGYSGSDVSIVVQDALMQPVRKIQQATHFKRVTVDGKEKLTPCSPGDPDAEEMTWEKVASEDLLEPLVEKKDFIRAIKSSRPTVSQVDLERNEEWTKEFGSEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PIB3</accession>
    <name>A0AAN6PIB3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">5'-3' exoribonuclease 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">C8A01DRAFT_46116</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Possesses 5'-&gt;3' exoribonuclease activity. Required for the processing of nuclear mRNA and rRNA precursors. May promote the termination of transcription by RNA polymerase II. Essential for vegetative cell growth and chromosome segregation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="18">Interacts with RAI1; the interaction is direct, stabilizes RAT1 protein structure and may stimulate its exoribonuclease activity. The interaction also stimulates RAI1 pyrophosphohydrolase activity, probably by recruiting it to mRNA substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854374">
        <property type="protein sequence ID" value="KAK4040560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18673">
        <property type="entry name" value="PIN_XRN1-2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05392">
        <property type="entry name" value="RasGAP_Neurofibromin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.1050:FF:000002">
        <property type="entry name" value="5'-3' exoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12390:FF:000003">
        <property type="entry name" value="5'-3' exoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12390:FF:000005">
        <property type="entry name" value="5'-3' exoribonuclease 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12390">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027073">
        <property type="entry name" value="5_3_exoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054071">
        <property type="entry name" value="PH_NF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023152">
        <property type="entry name" value="RasGAP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041412">
        <property type="entry name" value="Xrn1_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004859">
        <property type="entry name" value="Xrn1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341:SF41">
        <property type="entry name" value="5'-3' EXORIBONUCLEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341">
        <property type="entry name" value="5'-&gt;3' EXORIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13716">
        <property type="entry name" value="CRAL_TRIO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21877">
        <property type="entry name" value="PH_NF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17846">
        <property type="entry name" value="XRN_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03159">
        <property type="entry name" value="XRN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00509">
        <property type="entry name" value="RAS_GTPASE_ACTIV_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="15" id="KW-0804">Transcription</keyword>
    <keyword evidence="13" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0806">Transcription termination</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="19" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="22">
        <location>
            <begin position="271"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GAP" evidence="21">
        <location>
            <begin position="2234"/>
            <end position="2427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="413"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="508"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="870"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="2121"/>
            <end position="2140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="122"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="413"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="513"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="547"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="20">
        <location>
            <begin position="889"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="20">
        <location>
            <begin position="908"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="933"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="20">
        <location>
            <begin position="968"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="20">
        <location>
            <begin position="1002"/>
            <end position="1013"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00046137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00046943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KAK4040560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="3607" mass="399483" checksum="6BD63978192CD38F" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PIL6</accession>
    <name>A0AAN6PIL6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Calpain catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_46873</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C2 family. PalB/RIM13 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854394">
        <property type="protein sequence ID" value="KAK4039689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PIL6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00044">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022683">
        <property type="entry name" value="Calpain_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036213">
        <property type="entry name" value="Calpain_III_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051297">
        <property type="entry name" value="PalB/RIM13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46143">
        <property type="entry name" value="CALPAIN-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46143:SF1">
        <property type="entry name" value="CALPAIN-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25435">
        <property type="entry name" value="PalB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00720">
        <property type="entry name" value="calpain_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00230">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49758">
        <property type="entry name" value="Calpain large subunit, middle domain (domain III)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Calpain catalytic" evidence="7">
        <location>
            <begin position="99"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="718"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="110"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="347"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4039689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="875" mass="94739" checksum="FDA06AB3F3F3461F" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PIS0</accession>
    <name>A0AAN6PIS0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_36129</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854389">
        <property type="protein sequence ID" value="KAK4039901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PIS0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35006:SF3">
        <property type="entry name" value="GLYOXALASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_3G06020)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35006">
        <property type="entry name" value="GLYOXALASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G14830)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="2"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4039901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="183" mass="19618" checksum="101A7C5C6EE0ED4D" modified="2024-10-02" version="1">MPLNHISLPTTPSTYPPMRAFYLATLQPLGYKVFKEQAGVFLGLQGPDMSPDFWLHCGGGDDSDSDLPLADTSLTAEENKKMINGGRAHVAFGVGRRGLVGEWFVNAVKAGGIPNGEPGERRQYAKGYYAAFVLDPLGNNVEVVYFSPWWLKVINAVPGVVAVAFGAVAGHFAMGYAKGAGWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PIT5</accession>
    <name>A0AAN6PIT5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Origin recognition complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">C8A01DRAFT_16293</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">ORC is composed of six subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ORC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854392">
        <property type="protein sequence ID" value="KAK4039794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PIT5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04720">
        <property type="entry name" value="BAH_Orc1p_Yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000199">
        <property type="entry name" value="Origin recognition complex subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001025">
        <property type="entry name" value="BAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054425">
        <property type="entry name" value="Cdc6_ORC1-like_ATPase_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050311">
        <property type="entry name" value="ORC1/CDC6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048867">
        <property type="entry name" value="WHD_ORC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763:SF23">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01426">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22606">
        <property type="entry name" value="Cdc6-ORC-like_ATPase_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21312">
        <property type="entry name" value="WHD_ORC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82061">
        <property type="entry name" value="BAH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51038">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAH" evidence="12">
        <location>
            <begin position="73"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="219"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="565"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="219"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="229"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK4039794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="767" mass="84184" checksum="C085E90909BFE418" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PIX9</accession>
    <name>A0AAN6PIX9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_14568</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854352">
        <property type="protein sequence ID" value="KAK4041726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PIX9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF37">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR GPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="352"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="381"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="96"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="273"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="448"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="273"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="334"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="453"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4041726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="497" mass="54140" checksum="AB3BD2487E07B56D" modified="2024-10-02" version="1">MAGNGYDPLVEASGTISPLPPVLRQGLIAIATLSCLSFVSSMAVLLYLTVKFARWHLRNRRQHNATAGPSTPPVDLSLGLAERHYMGESAKHQGPLTRKRARPNQFLVLLYNLLLADLHQAASFLLNAVWVGRDGIQVGTATCWAQAWLIQVGDLASSLFITAIAVHTYLAVVWNYTPPQSAIYIAVVSLWAFNFMLVIIGIAITGNGREVGGFFVRATAWCWINVHYETLRLYLHYLWIFLALVLTSILYTLIFLSLRNKRGSQEASHNLNAAAATDSTTNIHDTDNDANSTTKTPSPTTLHPLPDTNPNPTQQGLAAAEGEAGEETTHPSATNTTTTTTNNNNNHHHRAFLLYPLIYILCTAPLALGRIATMAGVDVPISYFCTAGALITSNGCLDVLLWGVTRHRLLFSGDVGAEDSGLDTFAFMRTPHGRRWGNMVWVEGGQVHNNNNDGGGNGDGGGAEGGGKAGEGRRYSRDRRISFGQSLMAMTVWREWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PIY6</accession>
    <name>A0AAN6PIY6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Aspartic peptidase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_14457</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854350">
        <property type="protein sequence ID" value="KAK4041853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PIY6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06097">
        <property type="entry name" value="Aspergillopepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000024">
        <property type="entry name" value="Endothiapepsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000026">
        <property type="entry name" value="Endothiapepsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034163">
        <property type="entry name" value="Aspergillopepsin-like_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF2">
        <property type="entry name" value="ASPERGILLOPEPSIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042868457" evidence="8">
        <location>
            <begin position="18"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="9">
        <location>
            <begin position="98"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="300"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="336"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4041853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="423" mass="44253" checksum="F2F06F0FE19BAFCD" modified="2024-10-02" version="1">MRSLCFFAVTLAAGVLAGVLPPSPNISKAHRSGTLSLKQVRNPSFVRNGPVQLARIYHKYSAPLPDDLKAAVARIRSNTAKRSTGSAEPKPEENDVEYLTPVSIGTPEQVLNLDFDTGSSDLWVFSSETKKGDVQGQTIYDPNKSSTAKQLQGYTWQISYGDGSSSSGDVYTDTVTVGGLTVSSQAVEVAKKVSDEFTSDSNNDGLLGLGFSSINTVEPVAQKTFFDNAKSSLDAPVFTADLKAGAPGHFNFGYIDPSAHTSNITYVPVDNGDGFWAWKTSGYAVGSGSFKSTTFQGIADTGTSLLLLPSSVVSAYYGQISGAKYDSTQGGYTLSCSGSAPDFAFGVGGNDTTITVPGDYIKYAPTSSSGKTCFGGIQPDTGIGFSIFGDVALKAAFVVFDGGNQQLGWASKTLPSNSSAGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PJ29</accession>
    <name>A0AAN6PJ29_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Oxidase ustYa</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">C8A01DRAFT_14382</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the ustYa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854349">
        <property type="protein sequence ID" value="KAK4041919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PJ29"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF11">
        <property type="entry name" value="TAT PATHWAY SIGNAL SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0843">Virulence</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK4041919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="242" mass="27708" checksum="6A11F67362D0EEBD" modified="2024-10-02" version="1">MSSSKITYERVHAQDVSDEDEHATSEHDDLPLLVVSGREQRGPRNRRRSTACWLITLVLVAAAAALVSGTACFVWGQRVERDRAESDWFSPPGRIDHVFKYRRQFSERPSNNESQIWWNKVFPRGRGFIQHPEISPVPHGLAVFHQLHCLVRQYIKADAIRHGYWAAVDGIEPAHHAKPGHVRHCIDYLRQSIMCNADTNLEPIDPNLGGVTGWGFSRKCRDIVRLIGWADKWRTHNQTGHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PJT4</accession>
    <name>A0AAN6PJT4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cholesterol oxidase</fullName>
            <ecNumber evidence="13">1.1.3.6</ecNumber>
            <ecNumber evidence="11">5.3.3.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Cholesterol isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">C8A01DRAFT_36199</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="12">Steroid metabolism; cholesterol degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.3.6" evidence="13"/>
    <dbReference type="EC" id="5.3.3.1" evidence="11"/>
    <dbReference type="EMBL" id="MU854391">
        <property type="protein sequence ID" value="KAK4039820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016995">
        <property type="term" value="F:cholesterol oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004769">
        <property type="term" value="F:steroid Delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008203">
        <property type="term" value="P:cholesterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052542">
        <property type="entry name" value="Cholesterol_Oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47470">
        <property type="entry name" value="CHOLESTEROL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47470:SF1">
        <property type="entry name" value="FAD-DEPENDENT OXIDOREDUCTASE 2 FAD BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0153">Cholesterol metabolism</keyword>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="8" id="KW-1207">Sterol metabolism</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="17">
        <location>
            <begin position="223"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase C-terminal" evidence="18">
        <location>
            <begin position="633"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAK4039820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1379" mass="152126" checksum="88CFE9767C4A9E37" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PJX9</accession>
    <name>A0AAN6PJX9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_45491</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854359">
        <property type="protein sequence ID" value="KAK4041340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PJX9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042949643" evidence="1">
        <location>
            <begin position="17"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4041340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="153" mass="16041" checksum="109E8385161779FB" modified="2024-10-02" version="1">MKSFSSVLLLAGLATASPVARQTTGPYDITNFSASKVHLSGYCNFAFDVSAPGLSVPSHCTAYLDSGFSGATWLANVYEGAGKCDNAAVSWTFFQPTTAGSGATFNVTVNGVKGRYAVPAEDITVSLNSEPNPFDNDVAYTGPKAFEITEFVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PJZ2</accession>
    <name>A0AAN6PJZ2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_14062</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854343">
        <property type="protein sequence ID" value="KAK4042281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PJZ2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16464">
        <property type="entry name" value="RING-H2_Pirh2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039512">
        <property type="entry name" value="RCHY1_zinc-ribbon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008913">
        <property type="entry name" value="Znf_CHY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037274">
        <property type="entry name" value="Znf_CHY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017921">
        <property type="entry name" value="Znf_CTCHY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037275">
        <property type="entry name" value="Znf_CTCHY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21319:SF0">
        <property type="entry name" value="AND RING FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G08900)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21319">
        <property type="entry name" value="RING FINGER AND CHY ZINC FINGER DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05495">
        <property type="entry name" value="zf-CHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14599">
        <property type="entry name" value="zinc_ribbon_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161219">
        <property type="entry name" value="CHY zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161245">
        <property type="entry name" value="Zinc hairpin stack"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51266">
        <property type="entry name" value="ZF_CHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51270">
        <property type="entry name" value="ZF_CTCHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CHY-type" evidence="7">
        <location>
            <begin position="264"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="CTCHY-type" evidence="8">
        <location>
            <begin position="333"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="399"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="36"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="187"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="509"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="547"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="592"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="118"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="519"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="550"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="632"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="674"/>
            <end position="714"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4042281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="720" mass="79450" checksum="26FAE834F6B17F35" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PKZ1</accession>
    <name>A0AAN6PKZ1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Spermidine/spermine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_33252</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the spermidine/spermine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854337">
        <property type="protein sequence ID" value="KAK4042722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PKZ1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004766">
        <property type="term" value="F:spermidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.140.10:FF:000001">
        <property type="entry name" value="SPE3p Spermidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000013">
        <property type="entry name" value="Spermidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.140.10">
        <property type="entry name" value="Spermidine synthase, tetramerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00198">
        <property type="entry name" value="Spermidine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030374">
        <property type="entry name" value="PABS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030373">
        <property type="entry name" value="PABS_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001045">
        <property type="entry name" value="Spermi_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030668">
        <property type="entry name" value="Spermi_synthase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035246">
        <property type="entry name" value="Spermidine_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037163">
        <property type="entry name" value="Spermidine_synt_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002010">
        <property type="entry name" value="PRK00811.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00417">
        <property type="entry name" value="speE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11558:SF11">
        <property type="entry name" value="SPERMIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11558">
        <property type="entry name" value="SPERMIDINE/SPERMINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17284">
        <property type="entry name" value="Spermine_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01564">
        <property type="entry name" value="Spermine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000502">
        <property type="entry name" value="Spermidine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01330">
        <property type="entry name" value="PABS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51006">
        <property type="entry name" value="PABS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PABS" evidence="5">
        <location>
            <begin position="11"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4042722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="292" mass="33229" checksum="87D8C0F5C2D0B5A1" modified="2024-10-02" version="1">MGDITHATIQDGWFREISEMWPGQAMTLRVKKVLHHEKSKYQDVLIFESTDHGNVLVLDNVIQCTERDEFSYQEMITHLAMNSHPNPKKVLVIGGGDGGVLREVVKHECVEEATLCDIDEAVIRLSKQYLPHMAAGFNHEKVKVHIGDGFKFLDDYKNTFDVIITDSSDPEGPAESLFQKPYFKLLHDALREGGVITTQGSENQWLHLPLITKLKKDCGEIFPVAEYAYTTIPTYPSGQIGFMVCCKDATRNVREPVRSWPKDEERKLCRYYNADIHKASFVLPTFAQQALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PL14</accession>
    <name>A0AAN6PL14_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_32922</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854333">
        <property type="protein sequence ID" value="KAK4042978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PL14"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042981444" evidence="1">
        <location>
            <begin position="18"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4042978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="60" mass="6264" checksum="47F2AF9838CE4548" modified="2024-10-02" version="1">MQFTVATVLAFAAMAFAYPAVDSNSIVVKRQSNVEAQLPSMSDGTGNVIPFDATKVKGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PL26</accession>
    <name>A0AAN6PL26_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Signal peptide peptidase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_14364</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase A22B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854348">
        <property type="protein sequence ID" value="KAK4042000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PL26"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098554">
        <property type="term" value="C:cytoplasmic side of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098553">
        <property type="term" value="C:lumenal side of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042500">
        <property type="term" value="F:aspartic endopeptidase activity, intramembrane cleaving"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033619">
        <property type="term" value="P:membrane protein proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007369">
        <property type="entry name" value="Peptidase_A22B_SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006639">
        <property type="entry name" value="Preselin/SPP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12174:SF23">
        <property type="entry name" value="MINOR HISTOCOMPATIBILITY ANTIGEN H13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12174">
        <property type="entry name" value="SIGNAL PEPTIDE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04258">
        <property type="entry name" value="Peptidase_A22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00730">
        <property type="entry name" value="PSN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="82"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="288"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="430"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="453"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="503"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="503"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="531"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4042000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="569" mass="63527" checksum="7FB6327DB75F828D" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PM34</accession>
    <name>A0AAN6PM34_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nucleophile aminohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_12928</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854326">
        <property type="protein sequence ID" value="KAK4043539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PM34"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04514">
        <property type="entry name" value="Taspase1_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.30:FF:000007">
        <property type="entry name" value="Similar to threonine aspartase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.30">
        <property type="entry name" value="(Glycosyl)asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000246">
        <property type="entry name" value="Peptidase_T2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037464">
        <property type="entry name" value="Taspase1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10188">
        <property type="entry name" value="L-ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10188:SF8">
        <property type="entry name" value="THREONINE ASPARTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01112">
        <property type="entry name" value="Asparaginase_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="203"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="237"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="264"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="326"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="391"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="2">
        <location>
            <begin position="390"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4043539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="572" mass="60337" checksum="54E558224E6BE411" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PMC9</accession>
    <name>A0AAN6PMC9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Isotrichodermin C-15 hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">C8A01DRAFT_34859</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854363">
        <property type="protein sequence ID" value="KAK4041125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PMC9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009403">
        <property type="term" value="P:toxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11058">
        <property type="entry name" value="CYP60B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000047">
        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF29">
        <property type="entry name" value="BENZOATE-PARA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="444"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK4041125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="500" mass="57451" checksum="1E397FF4AB82D065" modified="2024-10-02" version="1">MSITLFNTLRPVGGIAAAIAGVLFLFLCIRSLYYTFFHPLAKVPGPKLYAFSDIPYLYHLLRGEWPRKLKQLHDEYGPAVRYTTNNVSFTTPGAWKTIYGHRTGSQDTFQKDRIFYRTTLSGHPNIITANDDDHRRHRRLLAHAFSEKALRGQEDIMKHYIDLFINKLRSMSSQGEAVDMVRWYNFATFDLIGDLAFGQPFGCLESGGYNPWVALIFQTIKQSVFGETMNRYPVLKSFASLVQPAALVRSREEHWALSEQTAKKRIESGNTTREDFMSYILRHNDEKGMTQGEIVENASVLIIAGSETTATQLSGTTFQLLTNPDKYEILVREIREAFESEEDITLLRVNGLEYMKAVFEEGFRLYPPVPNALPRRTPAKGEYIEGYWIPGDTAVGVPQWASYQSERNFRDAHKFVPERWLGDPEYAHDVRDVLQPFSVGPRNCIGKNLAYAEMRLILARLLWNFDLELMPESRKWSDQKTYLLWDKGAMNVKLSPVLRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PMF1</accession>
    <name>A0AAN6PMF1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="23">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">C8A01DRAFT_12732</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15 23">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38567"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:38568"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphocholine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38583"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:38584"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66132"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:66133"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a beta-D-glucosyl-(1&lt;-&gt;1')-N-acylsphing-4-enine(out) + ATP + H2O = a beta-D-glucosyl-(1&lt;-&gt;1')-N-acylsphing-4-enine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66036"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:22801"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:66037"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 22">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="23">Membrane</location>
            <topology evidence="23">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 23">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="27">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="23"/>
    <dbReference type="EMBL" id="MU854324">
        <property type="protein sequence ID" value="KAK4043743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070867">
        <property type="term" value="C:mating projection tip membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990531">
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
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        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
            <dbReference type="EC" id="3.2.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan degradation; xylan degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the glycosyl hydrolase 10 (cellulase F) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.8" evidence="11"/>
    <dbReference type="EMBL" id="MU854337">
        <property type="protein sequence ID" value="KAK4042720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PMF3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044846">
        <property type="entry name" value="GH10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001000">
        <property type="entry name" value="GH10_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490:SF35">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00331">
        <property type="entry name" value="Glyco_hydro_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00134">
        <property type="entry name" value="GLHYDRLASE10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00633">
        <property type="entry name" value="Glyco_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51760">
        <property type="entry name" value="GH10_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 11 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042826305" description="Beta-xylanase" evidence="12">
        <location>
            <begin position="20"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="GH10" evidence="13">
        <location>
            <begin position="42"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK4042720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="370" mass="41259" checksum="8902CB8CFFF412F6" modified="2024-10-02" version="1">MRLSTPLLASTLLGVPATAQLHDLAKKAGLLYFGAATDTPGQRERAPYPQSYAQYDAILNDPSEFGQTTPTNGQKWLFAEPQPRLFNFTEGDYVADLAHRTGKLLRCHALVWHSQLAPWVETTTWTPEELRAVIVRHIKAVAGYYKGQCYAWDVVNEALDEDGTYRKSVFYNVLGEEYIKLAFQTAAEVDPGAKLYYNDYGIERPGSVKTAGAVRLVKMLKDAGVRIDGVGMQAHLHADNHPTAEDLILTSEGYAALVKEVAFTELDVRIKTPVNETKLEWQKECYQKVVTACVKVKACVGITLWDFYDPFSWVPDVFPGNGASLVWFEDFSKHPAYDGMVETFKKLAGDKPGCKRRRRGVAARVEGDAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PN54</accession>
    <name>A0AAN6PN54_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_14687</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854355">
        <property type="protein sequence ID" value="KAK4041545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PN54"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051756">
        <property type="entry name" value="Centrosomal_MT-associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024957">
        <property type="entry name" value="Cep57_MT-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025925">
        <property type="entry name" value="PPC89_CLD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19336:SF9">
        <property type="entry name" value="SPINDLE POLE BODY PROTEIN PPC89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19336">
        <property type="entry name" value="UNCHARACTERIZED DUF1167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14197">
        <property type="entry name" value="Cep57_CLD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06657">
        <property type="entry name" value="Cep57_MT_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPC89 centrosome localisation" evidence="7">
        <location>
            <begin position="403"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="Cep57 centrosome microtubule-binding" evidence="6">
        <location>
            <begin position="1044"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="189"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="816"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="888"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1025"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="337"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="608"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="718"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="34"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="70"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="232"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="907"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1029"/>
            <end position="1045"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4041545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1167" mass="131494" checksum="F5FC197039FD7F3B" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PNA3</accession>
    <name>A0AAN6PNA3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2293 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_14047</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854343">
        <property type="protein sequence ID" value="KAK4042269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PNA3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018744">
        <property type="entry name" value="DUF2293"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38113">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38113:SF1">
        <property type="entry name" value="DUF2293 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10056">
        <property type="entry name" value="DUF2293"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2293" evidence="2">
        <location>
            <begin position="176"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="624"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="673"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="767"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="839"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="456"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="767"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="839"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="885"/>
            <end position="894"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4042269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="894" mass="99481" checksum="D5841EEF49B0EED9" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PNA8</accession>
    <name>A0AAN6PNA8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_31807</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854321">
        <property type="protein sequence ID" value="KAK4044199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PNA8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042893626" evidence="1">
        <location>
            <begin position="21"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4044199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="147" mass="14737" checksum="2735FA362AA56D7F" modified="2024-10-02" version="1">MQLSLSNSLLFLGLVGISSAAPAGQDITLPGGLPPTCIGFVDGAVKTPSCYTATTTKTVTPSICPLIKCVAPTDPIMCPMYIKVTTVAVPCSTDCCPQTPTATVTKSACPTCTTGCVIPTQTVTVTTGCKTALPGGILTPTATLIVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PNC0</accession>
    <name>A0AAN6PNC0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Survival protein SurE-like phosphatase/nucleotidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_42900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854320">
        <property type="protein sequence ID" value="KAK4044223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PNC0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1210.10">
        <property type="entry name" value="Survival protein SurE-like phosphatase/nucleotidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002828">
        <property type="entry name" value="SurE-like_Pase/nucleotidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036523">
        <property type="entry name" value="SurE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027746">
        <property type="entry name" value="TTL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004344">
        <property type="entry name" value="TTL/TTLL_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00087">
        <property type="entry name" value="surE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47551">
        <property type="entry name" value="TUBULIN--TYROSINE LIGASE PBY1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47551:SF1">
        <property type="entry name" value="TUBULIN--TYROSINE LIGASE PBY1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01975">
        <property type="entry name" value="SurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03133">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64167">
        <property type="entry name" value="SurE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51221">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Survival protein SurE-like phosphatase/nucleotidase" evidence="2">
        <location>
            <begin position="3"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="537"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="606"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="606"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="635"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4044223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="884" mass="96802" checksum="957A15820E5D3F17" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PNQ3</accession>
    <name>A0AAN6PNQ3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Septin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_13109</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854328">
        <property type="protein sequence ID" value="KAK4043425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PNQ3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032156">
        <property type="term" value="C:septin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000196">
        <property type="entry name" value="Cell division control 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="5">
        <location>
            <begin position="187"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="539"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="539"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4043425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="563" mass="64071" checksum="CFA099127213548E" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PPE8</accession>
    <name>A0AAN6PPE8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">NADH-ubiquinone oxidoreductase 78 kDa subunit, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">C8A01DRAFT_12871</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the complex I 75 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854326">
        <property type="protein sequence ID" value="KAK4043573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PPE8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02773">
        <property type="entry name" value="MopB_Res-Cmplx1_Nad11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.740:FF:000001">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.210:FF:000002">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 75 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.20:FF:000002">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 75 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.740:FF:000033">
        <property type="entry name" value="NUAM protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000283">
        <property type="entry name" value="NADH_UbQ_OxRdtase_75kDa_su_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054351">
        <property type="entry name" value="NADH_UbQ_OxRdtase_ferredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010228">
        <property type="entry name" value="NADH_UbQ_OxRdtase_Gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019574">
        <property type="entry name" value="NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015405">
        <property type="entry name" value="NDUFS1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050123">
        <property type="entry name" value="Prok_molybdopt-oxidoreductase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01973">
        <property type="entry name" value="NuoG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43105:SF13">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 75 KDA SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43105">
        <property type="entry name" value="RESPIRATORY NITRATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13510">
        <property type="entry name" value="Fer2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22151">
        <property type="entry name" value="Fer4_NDSU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22117">
        <property type="entry name" value="Fer4_Nqo3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10588">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09326">
        <property type="entry name" value="NADH_dhqG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00929">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53706">
        <property type="entry name" value="Formate dehydrogenase/DMSO reductase, domains 1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51839">
        <property type="entry name" value="4FE4S_HC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00641">
        <property type="entry name" value="COMPLEX1_75K_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00642">
        <property type="entry name" value="COMPLEX1_75K_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00643">
        <property type="entry name" value="COMPLEX1_75K_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="12">
        <location>
            <begin position="33"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S His(Cys)3-ligated-type" evidence="14">
        <location>
            <begin position="111"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="13">
        <location>
            <begin position="250"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00070722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK4043573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="743" mass="81201" checksum="FA332F6D7B2844E4" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PPF3</accession>
    <name>A0AAN6PPF3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_14132</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854344">
        <property type="protein sequence ID" value="KAK4042205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PPF3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="467"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="298"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="145"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="163"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="227"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4042205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="513" mass="56738" checksum="04C5016CC612733F" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PPN2</accession>
    <name>A0AAN6PPN2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_11902</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854317">
        <property type="protein sequence ID" value="KAK4044687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PPN2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="95"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="214"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="40"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="319"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="465"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="512"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="574"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="319"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4044687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="594" mass="64691" checksum="A99DCC4B9829B780" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PQ09</accession>
    <name>A0AAN6PQ09_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">proline--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Prolyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">C8A01DRAFT_31698</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Pro) + L-proline + ATP = L-prolyl-tRNA(Pro) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:14305"/>
            <dbReference type="Rhea" id="RHEA-COMP:9700"/>
            <dbReference type="Rhea" id="RHEA-COMP:9702"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78532"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.15"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.15" evidence="2"/>
    <dbReference type="EMBL" id="MU854321">
        <property type="protein sequence ID" value="KAK4044100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PQ09"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00862">
        <property type="entry name" value="ProRS_anticodon_zinc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00778">
        <property type="entry name" value="ProRS_core_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.110.30:FF:000001">
        <property type="entry name" value="Bifunctional glutamate/proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000007">
        <property type="entry name" value="Bifunctional glutamate/proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000005">
        <property type="entry name" value="bifunctional glutamate/proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.30">
        <property type="entry name" value="C-terminal domain of ProRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01571">
        <property type="entry name" value="Pro_tRNA_synth_type3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002316">
        <property type="entry name" value="Pro-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004499">
        <property type="entry name" value="Pro-tRNA-ligase_IIa_arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016061">
        <property type="entry name" value="Pro-tRNA_ligase_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017449">
        <property type="entry name" value="Pro-tRNA_synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033721">
        <property type="entry name" value="ProRS_core_arch_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00408">
        <property type="entry name" value="proS_fam_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43382:SF2">
        <property type="entry name" value="BIFUNCTIONAL GLUTAMATE_PROLINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43382">
        <property type="entry name" value="PROLYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09180">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01046">
        <property type="entry name" value="TRNASYNTHPRO"/>
    </dbReference>
    <dbReference type="SMART" id="SM00946">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64586">
        <property type="entry name" value="C-terminal domain of ProRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="11">
        <location>
            <begin position="90"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK4044100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="556" mass="62701" checksum="3E7F4AE7C68218EA" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PQI1</accession>
    <name>A0AAN6PQI1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_31730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854321">
        <property type="protein sequence ID" value="KAK4044128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PQI1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4044128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="109" mass="12959" checksum="70F412EF14E789CB" modified="2024-10-02" version="1">MFYPCQGVCSEPQVHHNWIPVFELLWESWACVRYVDIHFAPHEPQPIRRGSMSPPIRCRFEWDENVDGFWWGLQMFTMAHEIRFANPVPGYFVRQQAKQLGWHVEGTAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2025-10-08" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PRE0</accession>
    <name>A0AAN6PRE0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ankyrin-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_31987</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854323">
        <property type="protein sequence ID" value="KAK4043889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12885">
        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050889">
        <property type="entry name" value="Dendritic_Spine_Reg/Scaffold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044736">
        <property type="entry name" value="Gid1/RanBPM/SPLA_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24166:SF48">
        <property type="entry name" value="PROTEIN VAPYRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24166">
        <property type="entry name" value="ROLLING PEBBLES, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="981"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1157"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1190"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1305"/>
            <end position="1337"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="5">
        <location>
            <begin position="1425"/>
            <end position="1629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="792"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="845"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="807"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="847"/>
            <end position="872"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4043889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1682" mass="184743" checksum="7AAF5EB52B8F7510" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PSQ0</accession>
    <name>A0AAN6PSQ0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine/threonine-protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_31105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854317">
        <property type="protein sequence ID" value="KAK4044609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PSQ0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06293">
        <property type="entry name" value="Kdo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4044609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="164" mass="18473" checksum="2B8A2FF5A898E23A" modified="2024-10-02" version="1">MAHVVGLGSIILPDLAPIRYLGCRIRRGRITAIVLESLKWTLYSYAHERPSKFVGLDKEAFLAGVESAFKYLHSLGLAHNDINPHNIMMGETDDGGVCSPVLIDFDSCGLFGEQTHTGRTRGFADAEDVEEFVSLKRHDEFSLGRLREWWDEEHEPKEVDADED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SK60</accession>
    <name>A0AAN6SK60_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PNPLA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_21399</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854844">
        <property type="protein sequence ID" value="KAK4031361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SK60"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4031361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="59" mass="6065" checksum="EFF4ED3F5D3C33A3" modified="2024-10-02" version="1" fragment="single">FDMIGGTSIGGLIAIMLGRLRPTIDECIDAYTANRHPMHCKTRGQAGAEGAGFGGVAMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SKR6</accession>
    <name>A0AAN6SKR6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF1993 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_20851</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854661">
        <property type="protein sequence ID" value="KAK4032021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SKR6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="entry name" value="dinb family like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018531">
        <property type="entry name" value="DUF1993"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36922">
        <property type="entry name" value="BLL2446 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36922:SF1">
        <property type="entry name" value="DUF1993 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09351">
        <property type="entry name" value="DUF1993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="DinB/YfiT-like putative metalloenzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4032021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="175" mass="19218" checksum="1F8C1FB55C881AC1" modified="2024-10-02" version="1">MATLLYDLSVPTFLQTVSAVGGFLDRAATHCAETGADPDDYVNARLFHDMAPFRFQVECVAHHSVWALEAVKTGVFAPPALVGPQIPSADLRAMIAQAEAALKALPPDEVNSWAGKDLDLQLPPRKLAFTSETFLLSFSLPNFYFHAVTAYNILRTRGVPLGKRDYEGQLRTRLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SL85</accession>
    <name>A0AAN6SL85_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">3-carboxy-cis,cis-mucoante lactonizing enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_21349</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cycloisomerase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854817">
        <property type="protein sequence ID" value="KAK4031422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SL85"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050282">
        <property type="entry name" value="Cycloisomerase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019405">
        <property type="entry name" value="Lactonase_7-beta_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344:SF4">
        <property type="entry name" value="CYCLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10282">
        <property type="entry name" value="Lactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75011">
        <property type="entry name" value="3-carboxy-cis,cis-mucoante lactonizing enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4031422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="294" mass="31556" checksum="7DFBA599E2291249" modified="2024-10-02" version="1" fragment="single">ATGACFNTTSAFITAMPTEPYHVFSASWPGPNACGMSMSTSSTGALTGVLDTWSYINTSGIYGLALSPPTAPVNNTTRQLLYSADLNGDLLWTHTIDPATGRATESSRWPMTAAGMHPRHLAVHPNGAHLYAVMEADNSVAEYVLDPSTGAVLRERVRHMLIPIDADTAEYWSAEVMLSSGSGPRYLWATARGKGEDTTGFVSVFLLGDDGGIVKRMFRVPTTTKGGKANAVSPAFWGDEYAAMTDYPDGYVLMWKMEGRRERGDGLVEYTTARAVARVDVGDGGCCANAIWYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SLK7</accession>
    <name>A0AAN6SLK7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_20125</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854568">
        <property type="protein sequence ID" value="KAK4032876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SLK7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35391:SF7">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35391">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4032876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="456" mass="50986" checksum="68D8A0F3DC1C454F" modified="2024-10-02" version="1" fragment="single">MTLVLPEENGTGEIQGTVSEALDTVEATIDRLNRLGATIRRYSTADLENRVKAFTERHGDGNYFQLARQIVYFRYRTPMPSLLDQLAVSMANRRQRLRYIRRHQMKLGTPKTAVSQPKEHAIKVPPTTQLSGKDIRGSVISSSRSSTAFITEDLDGFPDPPKMEGGIAPPSCPFCGKPLTESDLKPGGWHRHVLEDVQPFICISEKCAETSRPFKDFALWAKHMREAHSVKWTEQVHKPIVWRCDVDHVAETFENEVDFREHLNAEHSEYTPAQQEAIYMSSKVTRRRLPNLCPICNADVVAAGSSRETTNDQLTKHIASHLRRLAFDSANNLDTRGDETASVESAISSNGKNGDGSKLRPASGVTDLLHVPLTFDDSTALKLRTETTEFDSDWTPADLEVLGSVLDSVPEKLSSTDILDWSVVIAKLKEDMKPEIFAELEHGQESESSDIILQHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SLT4</accession>
    <name>A0AAN6SLT4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_40438</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854551">
        <property type="protein sequence ID" value="KAK4033116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SLT4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4033116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="429" mass="48278" checksum="776365432A6245B3" modified="2024-10-02" version="1">MAPVLLFPDQAKATFASLPHDVLAIILRHSPDLDTFLSSIASCRAFFNAFKNAPTSLTKSLVDREVGDLLPQATFVVLARDARPHAHSPAEMAQAISQLLSRWADESVVLTHRWSLAEGIAAIRLDRIIGDLARRSAAFCLSWLEKLSGHSQESPSDSELARIKRALYRFELNCRLLPPVLDEEAADPVLEAGQLVFLQQGHPWENEQLASVHESLWRLVAPAYNEVAIHDIAWGAHGADYARDTSDTATEWLLSRGLRSIHDIARATTYDRRYELIGAGTEKPHHAFVFLSEAFDLQHTLIQEPRPEVVGAAVAGPAGLYEDPNPGPERFWRWAHPHLQHNDPRARLVESRYKPMRDCGYVFWDAKRLDSIGILDQRWADVEPAFKTQEDVFLNRPGHMRMKFSGHFRYQAYKKGIRGYYLLAGGKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SMD3</accession>
    <name>A0AAN6SMD3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Peptidase M14 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">C8A01DRAFT_40606</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the peptidase M14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854562">
        <property type="protein sequence ID" value="KAK4032954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SMD3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03860">
        <property type="entry name" value="M14_CP_A-B_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000084">
        <property type="entry name" value="Carboxypeptidase B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705">
        <property type="entry name" value="PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705:SF143">
        <property type="entry name" value="SLL0236 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M14" evidence="11">
        <location>
            <begin position="1"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="10">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK4032954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="243" mass="27233" checksum="8B5739BE3143FEC9" modified="2024-10-02" version="1">MVTEYIAYNLLNRYGLDGDVKHALDSFDFYILPVINPDGFVHSQLNPKNRLWRKNRQTQNGTACVGRDLNRNWDAHWDQRGGASARPCRATYRGSKPLDAPETRAIATELLAIRERQGIRLFVDWHAFGQLVMYPYGYSCDKKLPPFSATSWLAGELAEAMGKVHGTVYKAGTACELLYPTSGDSADYAFEVLGAEYAYTVELRPGLRGKGAAGFRLPEGQILGTAEEAWGGVRHVLRFIHRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SMG3</accession>
    <name>A0AAN6SMG3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_20388</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854598">
        <property type="protein sequence ID" value="KAK4032535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SMG3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="835"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="980"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="289"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="437"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="491"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="540"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="568"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="855"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="882"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="924"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1010"/>
            <end position="1020"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4032535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1020" mass="110115" checksum="C2C022571126C93F" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SMQ7</accession>
    <name>A0AAN6SMQ7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glyoxal oxidase N-terminus-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_19038</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854495">
        <property type="protein sequence ID" value="KAK4034106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SMQ7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02851">
        <property type="entry name" value="E_set_GO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.80">
        <property type="entry name" value="Galactose oxidase/kelch, beta-propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037293">
        <property type="entry name" value="Gal_Oxidase_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009880">
        <property type="entry name" value="Glyoxal_oxidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015202">
        <property type="entry name" value="GO-like_E_set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32208:SF105">
        <property type="entry name" value="COPPER RADICAL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32208">
        <property type="entry name" value="SECRETED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07250">
        <property type="entry name" value="Glyoxal_oxid_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09118">
        <property type="entry name" value="GO-like_E_set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042982554" evidence="3">
        <location>
            <begin position="24"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="4">
        <location>
            <begin position="34"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="4">
        <location>
            <begin position="146"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="4">
        <location>
            <begin position="265"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="4">
        <location>
            <begin position="374"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="236"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4034106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="989" mass="104030" checksum="637D11987D679CDC" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SNL6</accession>
    <name>A0AAN6SNL6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome b-c1 complex subunit 8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Complex III subunit 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">C8A01DRAFT_39676</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The complex plays an important role in the uptake of multiple carbon sources present in different host niches.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein, 2 core protein subunits, and additional low-molecular weight protein subunits. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with cytochrome c oxidase (complex IV, CIV).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
            <topology evidence="1 11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the UQCRQ/QCR8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854506">
        <property type="protein sequence ID" value="KAK4033868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SNL6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045275">
        <property type="term" value="C:respiratory chain complex III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.210:FF:000001">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.210">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004205">
        <property type="entry name" value="Cyt_bc1_su8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036642">
        <property type="entry name" value="Cyt_bc1_su8_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12119:SF2">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12119">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX UBIQUINONE-BINDING PROTEIN QP-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02939">
        <property type="entry name" value="UcrQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81508">
        <property type="entry name" value="Ubiquinone-binding protein QP-C of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK4033868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="107" mass="11794" checksum="7C21818B5299D8FC" modified="2024-10-02" version="1">MRPTQNLRGGGGGAPVGTHGNYLGNWGNFGGMKQKGIISYGIAPNRQYPLAGAAHDAFFNTWRRFSAQVLYWAPPMVAGYYILNWAIDRNHYLNSKQGRAEFGGSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SP43</accession>
    <name>A0AAN6SP43_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_18688</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854476">
        <property type="protein sequence ID" value="KAK4034512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SP43"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16454">
        <property type="entry name" value="RING-H2_PA-TM-RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051826">
        <property type="entry name" value="E3_ubiquitin-ligase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22765:SF411">
        <property type="entry name" value="OS02G0248440 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22765">
        <property type="entry name" value="RING FINGER AND PROTEASE ASSOCIATED DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="95"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4034512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="159" mass="17806" checksum="CE5F3C50B9E00208" modified="2024-10-02" version="1">MATTRDDLELSRRNPRSNSSIGTGSSSPRIRVCVFIEPAPSYGQLKADGGVTKIPPDQRGPSVEWQVVSSSINYWFQPLLVHRADHKLYTRISVICLEGFQDESLVRLLPCRHLFHAECIASWFLAHHDTCPICMAHNSHALLREETLPVPPPPAMLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SP59</accession>
    <name>A0AAN6SP59_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_49219</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854482">
        <property type="protein sequence ID" value="KAK4034365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SP59"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042834935" evidence="1">
        <location>
            <begin position="28"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4034365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="309" mass="34312" checksum="A5FB73CAACE5BD5E" modified="2024-10-02" version="1">MHKPRIWRQAIRLFLLLAASSPPGAHSTRTRKDLCGLSMHTSDIPDIGNFSIIDATWTVPEVVDREDGGLEAPYVSQGVALCCGDDCSTRLAAGMWAYPRFPNQLTSASAMFQLSPVFGPFLIPQRHHFDFNGSDVLWTRVEVLGPNYAKLQLPQRRTFSKSESRTPGSNTTITVDLGIGTRDGETILSIATRGNGEETHITQHPRYIDAEKPIFCGDSAWWYLSDNFDPGEDTARPVPLARFSPVLVGDHGLQTTEKRSFPKELPLSGLARFWNMVRDTEGRTDVLCNARGFVDTGMTMLHAPHEWGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SQB8</accession>
    <name>A0AAN6SQB8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_47995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854431">
        <property type="protein sequence ID" value="KAK4038360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SQB8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052184">
        <property type="entry name" value="SDR_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458:SF3">
        <property type="entry name" value="CHAIN DEHYDROGENASE (ATSC), PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE SDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4038360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="273" mass="29387" checksum="F7FD5F6A846AF89F" modified="2024-10-02" version="1">MPSYLITGVSRGIGYEFMRQYSNDPNSTVIGLVRDKTATLEKVSEDLDLKGRRNIHIVQADLTDYNALQAAAAETARITGGSLDYLIANAALVTMFDTYDPIGALGDQPEMLTKTLRDLFEVNVIGNIHLFNLFTPLILKGQAKKVIAISTGLADPVFTSSYDVTPGALYAASKAALNMVVAKYSAQYKKDGVLFLALSPGFVEVGHYKDMTAEQMEGLGGLMATFAEYAPHFKGPITPEQSVAAVKSVIASASVEKGNGGDFLSHHGNKQWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SQI3</accession>
    <name>A0AAN6SQI3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_36676</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854402">
        <property type="protein sequence ID" value="KAK4039379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SQI3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042920324" description="GATA-type domain-containing protein" evidence="1">
        <location>
            <begin position="28"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4039379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="67" mass="8091" checksum="6DF36B5803462F0A" modified="2024-10-02" version="1">MIFIPWCCGEGYPRWWWWWLWGTSVWAVRDGPFGPRSLCNNCGFIFECDRKLPRWTKLLHAADARPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SQM1</accession>
    <name>A0AAN6SQM1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Actin-related protein 2/3 complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_37379</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
            <location evidence="6">Cytoskeleton</location>
            <location evidence="6">Actin patch</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ARPC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854422">
        <property type="protein sequence ID" value="KAK4038675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SQM1"/>
    <dbReference type="SMR" id="A0AAN6SQM1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1460.20:FF:000001">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1460.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034666">
        <property type="entry name" value="ARPC2/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008384">
        <property type="entry name" value="ARPC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22629:SF0">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22629">
        <property type="entry name" value="ARP2/3 COMPLEX 20 KD SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05856">
        <property type="entry name" value="ARPC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039100">
        <property type="entry name" value="ARPC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69645">
        <property type="entry name" value="Arp2/3 complex subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00054835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR039100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4038675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="169" mass="19653" checksum="2522C1D912978992" modified="2024-10-02" version="1">MSQSLRPYLQAVRSSLTAALCLSNFASQTAERHNVPEVEARTSPEVLLTPLTIARNENERVLIEPSINSIRISIKIKQADEIEHILVHKFTRFLTQRAESFFILRRKPIKGYDISFLITNFHTEEMLKHKLVDFIIQFMEEVDKEISEMKLFLNARARFVAESFLTPFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SQP1</accession>
    <name>A0AAN6SQP1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_47801</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854424">
        <property type="protein sequence ID" value="KAK4038601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SQP1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF149">
        <property type="entry name" value="GTPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11890)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="5">
        <location>
            <begin position="42"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="4">
        <location>
            <begin position="606"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="412"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="728"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="418"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="728"/>
            <end position="738"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4038601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="789" mass="88565" checksum="2D0F4275191ACD3D" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SQQ4</accession>
    <name>A0AAN6SQQ4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PUA-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_17365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854425">
        <property type="protein sequence ID" value="KAK4038573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SQQ4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.400.10">
        <property type="entry name" value="Sulfate adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007374">
        <property type="entry name" value="ASCH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009326">
        <property type="entry name" value="DUF984"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39203:SF1">
        <property type="entry name" value="CYTOPLASMIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39203">
        <property type="entry name" value="CYTOPLASMIC PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04266">
        <property type="entry name" value="ASCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01022">
        <property type="entry name" value="ASCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ASCH" evidence="1">
        <location>
            <begin position="33"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4038573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="171" mass="18535" checksum="C03B5CFEF392C269" modified="2024-10-02" version="1">MSAIDPSRPDIVAFMAGASSALGCTLPPPKDVFNFGGPSPALADERLLLAVQGKKTATTSWPVPDPLYWGVGDMSVILDGKGAPTALMRTTSLVQCRFRDVDEEFALAEAEGDYEAYRTGHVTFYRLQENGEAFGDESVVLCERFEVIYSVLGEQQDVRPVGIADSDQCHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SRH1</accession>
    <name>A0AAN6SRH1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_47145</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854402">
        <property type="protein sequence ID" value="KAK4039353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SRH1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080042">
        <property type="term" value="F:ADP-glucose pyrophosphohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080041">
        <property type="term" value="F:ADP-ribose pyrophosphohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006753">
        <property type="term" value="P:nucleoside phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019693">
        <property type="term" value="P:ribose phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03424">
        <property type="entry name" value="NUDIX_ADPRase_Nudt5_UGPPase_Nudt14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000068">
        <property type="entry name" value="NUDIX family hydrolase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839:SF18">
        <property type="entry name" value="NUDIX HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839">
        <property type="entry name" value="UDP/ADP-SUGAR PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="159"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4039353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="315" mass="34422" checksum="901F1830A8FE0B27" modified="2024-10-02" version="1">MPIILAALYQSRTALLRTWTSSPIASRLAWPSPTAKMSTFHHPDYHTPITLPPGLSKSQLLAFPPFTAWLTTLQTSLTTQTTTPTHPFHSDPYALHSITVQSFDLFGPTRLGFVKLTSHIANGAGEALPGAVFLRGPSVAMLVMLIPDDIPENKEEVEDEERYVLLTVQPRIAAGSLEFVELPAGMVDEGGSFAGQAAREMEEELGMVIGEGELVGLSDLVGETGEAKEEGGLPRAVYPSAGGCDEYIPIYMHERRVPRAQLGQWTGKLTGLREHGEKITLKLVKMRDLWREGARDAKCLAAVALWEGLRREGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SRR7</accession>
    <name>A0AAN6SRR7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_35779</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854382">
        <property type="protein sequence ID" value="KAK4040177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SRR7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042860455" evidence="1">
        <location>
            <begin position="18"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4040177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="354" mass="37552" checksum="270E9D91F55D02CE" modified="2024-10-02" version="1">MKVVLCSLLGHLGAIAGCPPQDHCLRAVIGHPHSARNGTADCQSYLQATVTAPASTFTSTVMVTTEAPTSTTQVDVVTEVETITVSTETTVQPSGVAARGDNHWDPPMPGYAWGACHSSDKYKSACARVGVLPTTITVPGPSTTVTVTETISTGGVATSSTTVTVLSSVTATTLVTSVATLSTAVATVTTTTTVTATVTATPDANIVPNGTFESGTLAGWTPADNVTAEVVSPGSNSTFSLQLGPMYDRLYHRVYTTVAGVPQTNYTCRYEWQFKYYLVSRPDSYLPVVRVLIDSVIVSSDFPRASWAGVFHAKSFNYTSKGEDVFEFFAYSAQHQSDGENWFYLDNFSCMPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SRS8</accession>
    <name>A0AAN6SRS8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acyltransferase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_15880</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854382">
        <property type="protein sequence ID" value="KAK4040207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SRS8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036149">
        <property type="term" value="P:phosphatidylinositol acyl-chain remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07990">
        <property type="entry name" value="LPLAT_LCLAT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032098">
        <property type="entry name" value="Acyltransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983">
        <property type="entry name" value="1-ACYLGLYCEROL-3-PHOSPHATE ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983:SF16">
        <property type="entry name" value="LYSOCARDIOLIPIN ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16076">
        <property type="entry name" value="Acyltransf_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="339"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="5">
        <location>
            <begin position="86"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4040207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="368" mass="42506" checksum="4F00300AACE7E36A" modified="2024-10-02" version="1">MEALTLDSRHGSIHATQLIGAPLYWLNRELYYAYMALTKQSFGLLITTMTHWWGPTTIRISGDASVADQIRKTKDGLVEFSFPERMIMIANHQIYTDWLYLWWVGYANTPKMHGSLFIILKESLKYIPLVGPGMMFYGFIFMSRKMAVDQPRMAHRLGKLKTAHTAPDGKKYLDPMWLLLFPEGTNASQNGRNKSAKWAAKIGVKDPEHMLLPRSTGTYFCLNELKGTVDYVYDCTVAYEGVTRGKFGEKIFTLAGTYIKGQTPKSVNFYWRRFRVADIPLDSPEEFDLWLRERWYEKDALMEQYVSTGRFPPNPADAVTKGQEPFLETEVRTRYPWEFLQIFSVLGAFALVVNFLLKTWNRFLSVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SSN6</accession>
    <name>A0AAN6SSN6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosome biogenesis protein RLP24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_15519</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854373">
        <property type="protein sequence ID" value="KAK4040598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SSN6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902626">
        <property type="term" value="P:assembly of large subunit precursor of preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00472">
        <property type="entry name" value="Ribosomal_L24e_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.170.20:FF:000001">
        <property type="entry name" value="probable ribosome biogenesis protein RLP24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.20">
        <property type="entry name" value="Ribosomal protein L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038630">
        <property type="entry name" value="L24e/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056366">
        <property type="entry name" value="Ribosomal_eL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000988">
        <property type="entry name" value="Ribosomal_eL24-rel_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011017">
        <property type="entry name" value="TRASH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792:SF8">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN RLP24-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01246">
        <property type="entry name" value="Ribosomal_L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00746">
        <property type="entry name" value="TRASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="TRASH" evidence="5">
        <location>
            <begin position="6"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="195"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="205"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4040598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="220" mass="25700" checksum="969E5A1543473811" modified="2024-10-02" version="1">MRIENCFFCGRPAWPSKGITFMRNDGKSFRFCRSKCHKNFKMKRNPRKLKWTKAYRKNAGKEMVVDSTLQFAARRNVPVRYDRELFAKTLKAMERIGEIRSRRERLFYKKRMAGKRAREVAAARKLVADNEHLLPRLRGSEKRRLAELAAERGVDVEELEREELATLRSSKKTKAFGGEVRRLRVRTDGGVEEITESVAGHMHEDGDDDEDDEDDEMDTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SST0</accession>
    <name>A0AAN6SST0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_15439</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854371">
        <property type="protein sequence ID" value="KAK4040718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SST0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000736">
        <property type="entry name" value="Polyadenylate-binding protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050441">
        <property type="entry name" value="RBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48034">
        <property type="entry name" value="TRANSFORMER-2 SEX-DETERMINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="183"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="368"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="70"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="459"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="591"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="70"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="463"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="517"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="602"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4040718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="612" mass="66228" checksum="653549C9B9995BB5" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6ST49</accession>
    <name>A0AAN6ST49_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_14683</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854354">
        <property type="protein sequence ID" value="KAK4041602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6ST49"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06532">
        <property type="entry name" value="Glyco_transf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050757">
        <property type="entry name" value="Collagen_mod_GT25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002654">
        <property type="entry name" value="Glyco_trans_25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10730:SF53">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 25 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10730">
        <property type="entry name" value="PROCOLLAGEN-LYSINE,2-OXOGLUTARATE 5-DIOXYGENASE/GLYCOSYLTRANSFERASE 25 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="185"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="200"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4041602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="413" mass="45883" checksum="ADC6222773385622" modified="2024-10-02" version="1">MARWRPIHLIILLWFVVSLIFIARRYIAPFRGSFDLPGLRHVPVEGHDESVLREASIEHASNSTLGFHAIYYINMKARYDRSDAASLQAYIFGLNLHAYPGVEPDMTGTVGMPPTHRPSALKIGEKGSWRAHVNVWAEMVRNKLPPVLIMESDATWDINVRPIMGNLNKHFVEFLRHINSTPVHDPSWGGKENHHHPHTASPPPPTPPLPIPYTPTDPWLNTHWDPLSLGHCYEHPPQDKKEPHLIYPDPSVPLGNSYFGLPLGHERVIRRWGGITCTTAYALSHTGAAKLLLCSAVDLDNPADLLIRRLTLSGGLVAYSVSPPVVAQWVYRRGVGMGGAQSDVHGAGGDGEQQDMPGDVGMLGWEEVGRTGTVWGYYYENVTFDKMALGVVWREIMGGAVLADSWYDTESGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6STK3</accession>
    <name>A0AAN6STK3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_45138</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854351">
        <property type="protein sequence ID" value="KAK4041810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6STK3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF238">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G01680)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="12"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="312"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4041810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="447" mass="49661" checksum="E45FBBC458DAD83B" modified="2024-10-02" version="1">MGEQISPDEGIHVIIIGAGLAGLSAALSTKLANPAHRVTVLEAVKELQEVGAGLQITPNGTRLLAAWSLLPHLTPLAAVPSSLSVHRYDGTKLLAHEPALQQQMHARYGHPFWDLHRVDLQQAMVSKCLSLGVDLRLDARVAGVDFDDARVHLHHSRSGEEDPGEAVVQGDVVLLADGLWSHIRPAFLGRPSPAILTGDLAYRITIRADELEGEDAEELRGFIRDAAVHFWIGPRAHCVGYSVRGGEVYNLVFLCPDDLPGGVVKREGDMDEMRARFAGWDPLLGRFLRQVRGVVHKWKLMWLDALPEWANKKGTFFMAGDCCHPMLPYLAQGANSSLEDGAVLGSLLGRVRKSEMGRQLPCVSRLYQQLRMERGRKIQLETFRQRDDSHMEDGEAQEKRDALMVSMLGKELKGPFPSRWTCPEIQPFLYGYDAYAEAEKAYQENPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6STK6</accession>
    <name>A0AAN6STK6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_14265</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854346">
        <property type="protein sequence ID" value="KAK4042082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6STK6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043034539" evidence="3">
        <location>
            <begin position="28"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="177"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="267"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="352"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4042082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="365" mass="38351" checksum="BC61BD0F5E628EDB" modified="2024-10-02" version="1">MAPRSSLLGINAALCLLFASFAHEAAAIPFPKDDLHAAGYGYLMPRQCNQYCGYNNMFCCEDGTQCFTSGGYAGCSSTAGGGWARYTTTWTLTQTFTKTYNSYIPAATAPPGGGNCVPPEGSGQIACGNICCANWQYCAYDGHGTATTMTGTTAGVTNTAEAGVNPGGTSGGLSGGAIAGIVIGTIAGVGLLLLICACCVVRGLWHGLLALLGIGKKKTESVIEEEERYHHRRGSSHAHRDTHSSWYSGRPASAAARKEKGKSSSGAGLLGMGAALGTLALLLGLRRDKNKKKAAPSKTGRSDVSSSYWSDSYTATSPSSRSSDRRTRHSRHSRAPSRVTRTTHTHTRVSRSRAPSQRSQRSPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6STY1</accession>
    <name>A0AAN6STY1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Intradiol ring-cleavage dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_34043</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854349">
        <property type="protein sequence ID" value="KAK4041933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6STY1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03457">
        <property type="entry name" value="intradiol_dioxygenase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.130.10">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000627">
        <property type="entry name" value="Intradiol_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015889">
        <property type="entry name" value="Intradiol_dOase_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34315">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34315:SF1">
        <property type="entry name" value="INTRADIOL RING-CLEAVAGE DIOXYGENASES DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00775">
        <property type="entry name" value="Dioxygenase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49482">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043042092" evidence="2">
        <location>
            <begin position="20"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="Intradiol ring-cleavage dioxygenases" evidence="3">
        <location>
            <begin position="131"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="360"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4041933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="419" mass="43486" checksum="2A3D5425C82043E6" modified="2024-10-02" version="1">MLFNKAVSGLAVLAGIVAAHPGHDVRQEAAERRAYLQSAKRTSLAHCADKLKARGTEARNVARRQAVVEKARQRRGLKKRDFDAVLGTDHNKTSLGYTENTDAATLFAGYKSCLLTPEVTQGPYYVAGEYVRENIVEDQPGLSLLLDYQVIDVDTCEPVPDVYVEMWHCNSTGVYGGVVANGNGDSSDASNINNTWLRGIQPTNDDGVAQFESVFPGHYTGRATHIHIMVHTNATLQANKTLGLDNYASHVGQAFFDQTLIAAVDEVAPYSSNTQPLTENADDSIMREEAATEGVDPIVEYTLLGDSIEDGLFAWIAFGIDSSKSESISPAVYYQEGGGVANPNGGMGGGPGGGPGSGFPSGSAGVRPSGSAGAPPSGGAAASATSAVAAAESSSSAASATGGARPTGGRGIGCGRGQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SU44</accession>
    <name>A0AAN6SU44_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-carboxy-cis,cis-mucoante lactonizing enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_44608</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854342">
        <property type="protein sequence ID" value="KAK4042350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SU44"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011048">
        <property type="entry name" value="Haem_d1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51004">
        <property type="entry name" value="C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042878712" evidence="1">
        <location>
            <begin position="20"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4042350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="462" mass="50393" checksum="9DF3C65F0CA38F84" modified="2024-10-02" version="1">MKSSLAHLVPLAALGQCLSLPPLIPSIPGVTEALNNLAPPLPILQVPTPALDSPPFTASDIKPKKIGYFWTGAGDKQHKDFLATYSLDDDTFGTLLWVTDVPSSGNDPHHLGPSLDGKTLVGGGLLSLLKTQDTAFYFDTTNPYRPTFKKSNRGILSSIADEIRAKPDGGFYITYMGSAVGTTPGRLVETDADFNIIHEWPEDVPGVLNILGEQFNPHGLSIDWERKNILTSDFVEPISILKPSLGINRADTLRLWDLDTKQILNTITIPNGGGIQDVKHIPGNPEGAALATAVHLGQVWIIYPERKDANGKPGVAELLYDLGPKARDTVAIYSDISQDGRFIYLTLTTANHIAALDISDLNNVKRLDNPDEEQPTIGPHYVKIAPDQKHLLVTDYFVQTGAIGLINTPADFKALYIDILDDGSLSFNRSIDFNREFANRGGAKPHSSVIFDLTDPEKPLYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SUR8</accession>
    <name>A0AAN6SUR8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_33054</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the ANP1/MMN9/VAN1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854335">
        <property type="protein sequence ID" value="KAK4042803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SUR8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000136">
        <property type="term" value="C:mannan polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000017">
        <property type="entry name" value="Mannan polymerase II complex ANP1 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052086">
        <property type="entry name" value="Mannan_Polymerase_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43083">
        <property type="entry name" value="MANNAN POLYMERASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43083:SF2">
        <property type="entry name" value="MANNAN POLYMERASE II COMPLEX ANP1 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03452">
        <property type="entry name" value="Anp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="458"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="476"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4042803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="488" mass="55033" checksum="66F797E1EDA56AE0" modified="2024-10-02" version="1">MLPFASSGSKVTPRHHVSGYSNGYPRGKTFDISPHRYQPRGTAPTHRRRTQSLVRIGIVAAILFLLLLYTFTRGSSSSSSSSVLSVFSLGLLSSGGADFQLETVRYHDLSNVQGTARGWEREERILVCVPLRDAEAHLPMFFSHLRNLTYPHHLLDLAFLVSDSKDNTLGTLTKNLEDIQAAEDEAMHFGEISIIEKDFGQVVNQDVESRHGFAAQAGRRKLMARARNWLLTAALRPYHSWVYWRDVDVETAPFTILEDLMRHNKDVIVPNVWRPLPEWLGGEQPYDLNSWQESDTALTLADTLDEDAVIVEGYAEYATYRPHLAYLRDPYGDPDVEMELDGVGGVSILAKAKVFRYGVHFPAFSFEKHAETEGFGKMARRMDLSVIGLPHYTIWHAYEPSVDDIKHMEQMKREQLAQEQAEKEKAEKAMKLKESFGDATGQWEKDKLEMQNIAVQDKKKDTAAAPAAVGNVVDKVAARQEQQEDGKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SV64</accession>
    <name>A0AAN6SV64_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_31616</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854320">
        <property type="protein sequence ID" value="KAK4044299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SV64"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF17">
        <property type="entry name" value="O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="4">
        <location>
            <begin position="240"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4044299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="408" mass="45642" checksum="43A6E12CBDA4EA56" modified="2024-10-02" version="1">MAENKANGHVNGADGSDAQKVQNVLQSLEDIQPGSFTNDGDRIRVVAAAHAAISRLETPWDFVLRTCMGQPALGAALKIGKDLGLYDKWQERGNEQMTRHELSGMLPACDPELLFRILRHLAANHVLEETSIGVFKPTVLSRSFTQPVFGEWINHLYDATLPIFYHMPLFLAHTRYRNPTDPANGVFQHAKRWTGDMFDYYAAHPVEGASFNHVMGGVMAHQARWVDIFPAERLLETDRGGDTPLLVDVGGNIGHDVEKFREVHPATAARLYLEDRPEVVKLAKCPAEVHKLGYDFFTPQPIKGARVYYMHGVLHDWSDEPARKILEMQRDALVPGYSTLLVHDHVAPETLAHAHATAYDMTMMGMVAGGERKEADWRRLLKSAGYRVVKIWTSPLAIQGIIEAELDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SVJ7</accession>
    <name>A0AAN6SVJ7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_12785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854325">
        <property type="protein sequence ID" value="KAK4043716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SVJ7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="175"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4043716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="553" mass="60619" checksum="73C7309BBAD73BC6" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SVP6</accession>
    <name>A0AAN6SVP6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_31858</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Epoxide hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854322">
        <property type="protein sequence ID" value="KAK4043985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SVP6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43329">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="51"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4043985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="355" mass="39647" checksum="2E8316F24F9A22C6" modified="2024-10-02" version="1">MAATTTPDKLTPTDPRVQHRTYTIPASPYNKTYHYLLAEPPSGTPATATCLLVHGFPDLSFGWRYQVPYLVSLGLRVIVPDLPGFGRTDAPQELGAYSYKSVIDDLVAIVRHVQGKKDGEDVEKILLGGHDWGGAVVWRFALWYPEVLRCVFSVCTPFLPVNETFYSKEQIVQMLPNFGYQLQFEGTEVEEAVVGREMIRAFLSVMYGARRADGEAVFGVAKGLRKELLEPEKIGESPLVSREEMDFYADEYVKNGMRGPLCWYKTNRVNFDEDRVLLEQGKTKVTVPSLMVVASRDAALPPAMSAGMGEYVPDLVKREVDATHWALWEAPAETNKHIGEFLEGILKGQPLKASI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SVR6</accession>
    <name>A0AAN6SVR6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_31967</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854323">
        <property type="protein sequence ID" value="KAK4043868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SVR6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040324">
        <property type="entry name" value="WDR44/Dgr2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14221">
        <property type="entry name" value="WD REPEAT DOMAIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14221:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="336"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="399"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="439"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="181"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="712"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="799"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="853"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="31"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="97"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="801"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="871"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="910"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="929"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="964"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1019"/>
            <end position="1038"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4043868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1126" mass="119046" checksum="42A2F1E78D87D03E" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P3T5</accession>
    <name>A0AAN6P3T5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_42288</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854950">
        <property type="protein sequence ID" value="KAK4031233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P3T5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF5">
        <property type="entry name" value="HEAT SHOCK 70 KDA PROTEIN 12A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4031233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="67" mass="7705" checksum="662E1E2391E44974" modified="2024-10-02" version="1">MEEMFDPVVRDVLRLVSQQVEESSRKGKRINFVVLVGGFGNSDYLKRKLDAWCATNGGIKCIRPNFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P4B5</accession>
    <name>A0AAN6P4B5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_51424</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854778">
        <property type="protein sequence ID" value="KAK4031519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P4B5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031353">
        <property type="entry name" value="NACHT_sigma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031352">
        <property type="entry name" value="SesA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17106">
        <property type="entry name" value="NACHT_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17107">
        <property type="entry name" value="SesA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NACHT-NTPase and P-loop NTPases N-terminal" evidence="3">
        <location>
            <begin position="10"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="NACHT-NTPase sigma" evidence="2">
        <location>
            <begin position="163"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4031519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="204" mass="22040" checksum="B256C4CBAD60F503" modified="2024-10-02" version="1">MSVTVSNSLADTINAVEAAANYYNSVKDDKSLREAFHEAGRGQGLVRQALQAANSNLGGHKPTERTADLVEACHAKAKLSEGIFKEVAQAPEDSRFERYKAAVRQSRGSMVEVLTVGMMKDMCELAEDDAIKVVMEDRVMELRDAMAKLSKMEPSVPTEEAGHNFTNWGRDQINAPGGTVNRSEGSGNHFPGATFSGSVSFGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P4F4</accession>
    <name>A0AAN6P4F4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase M6-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_21226</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854756">
        <property type="protein sequence ID" value="KAK4031579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P4F4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008757">
        <property type="entry name" value="Peptidase_M6-like_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03296">
        <property type="entry name" value="M6dom_TIGR03296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41775:SF1">
        <property type="entry name" value="PEPTIDASE M6-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41775">
        <property type="entry name" value="SECRETED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05547">
        <property type="entry name" value="Peptidase_M6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M6-like" evidence="1">
        <location>
            <begin position="29"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4031579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="274" mass="29982" checksum="7765C81479DD6D8B" modified="2024-10-02" version="1" fragment="single">HAGTGAEQTGNPNDIWSVKWTLERERQLNNVKVYGFLTIPEDAKIGVSAHEIGHLLFGWPDLYDTDSTSAGIGNWCLMSHGSWGGGGDRPVHPSAWCKANQGWITVSNETENHQITLPDVKSSRKTHRLWKDGDASSQEYFLLENRQLTGFDTSLPASGLLVWHIDDTVNSNTNEWHPKVGLLQADGFQQLEFKSSFGDAGDPFPGIANETTLNATSSPNSKAYSGMDTYVSVTNIPVISASMTLDITVKAITPPPSGAFNPKMWYRLTNTFAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P4S4</accession>
    <name>A0AAN6P4S4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Kinetochore Sim4 complex subunit FTA2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_21077</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854708">
        <property type="protein sequence ID" value="KAK4031759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P4S4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025213">
        <property type="entry name" value="Sim4_Fta2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13095">
        <property type="entry name" value="FTA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4031759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="281" mass="32186" checksum="8F04DE95B249ADA5" modified="2024-10-02" version="1">MAGRQKARRVRRLLPLPRCDGPKLHPFEHQNAPIEWLERLAGDRGSQSGGEGSVFKVRINSRLYALKVFKFFNPLTADNNWDMMVDDSVPLKTVIFHIDPFYAECRAYGRIKQAQGERRLKREVVVPCHGYLFLQERDAQLLREKGVDLDDGVVDNGLLRVNKEDGRVRAIVKDFVPGGAGIDTTRSLRKILRDIRSLNKLGIYVRDIRADNFRAGQLVDFGLSHTEPHCVLDSLDEGMVRHYKVEDLVMFDNMVVEEGLVTNVRAMPNRAYCLKLRSRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P587</accession>
    <name>A0AAN6P587_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Meiosis protein SPO22/ZIP4 like-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">C8A01DRAFT_51104</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854664">
        <property type="protein sequence ID" value="KAK4031996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P587"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090173">
        <property type="term" value="P:regulation of synaptonemal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn cluster transcription factor Rds2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056751">
        <property type="entry name" value="PAS_13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039057">
        <property type="entry name" value="Spo22/ZIP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013940">
        <property type="entry name" value="Spo22/ZIP4/TEX11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
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        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40375:SF2">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24990">
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    </dbReference>
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        <property type="entry name" value="SPO22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0469">Meiosis</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="10">
        <location>
            <begin position="50"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="79"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="585"/>
            <end position="621"/>
        </location>
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        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
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            <begin position="79"/>
            <end position="90"/>
        </location>
    </feature>
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        <location>
            <begin position="94"/>
            <end position="105"/>
        </location>
    </feature>
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        <location>
            <begin position="585"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK4031996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1260" mass="139117" checksum="4AC88A0911A27753" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P5B8</accession>
    <name>A0AAN6P5B8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DMAP1-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_41662</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
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        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010506">
        <property type="entry name" value="DMAP1-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056881">
        <property type="entry name" value="Mug62_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22754:SF32">
        <property type="entry name" value="DISCO-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22754">
        <property type="entry name" value="DISCO-INTERACTING PROTEIN 2 DIP2 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23024">
        <property type="entry name" value="AMP-dom_DIP2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06464">
        <property type="entry name" value="DMAP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24919">
        <property type="entry name" value="Mug62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01137">
        <property type="entry name" value="DMAP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51912">
        <property type="entry name" value="DMAP1_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DMAP1-binding" evidence="2">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="647"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="1682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1744"/>
            <end position="1879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="668"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1657"/>
            <end position="1667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1668"/>
            <end position="1678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1747"/>
            <end position="1760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1793"/>
            <end position="1808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1809"/>
            <end position="1821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1822"/>
            <end position="1835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1842"/>
            <end position="1852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1856"/>
            <end position="1870"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4031900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1895" mass="207452" checksum="13388D4FEB4B8459" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P5I7</accession>
    <name>A0AAN6P5I7_9PEZI</name>
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        <recommendedName>
            <fullName evidence="2">alpha-galactosidase</fullName>
            <ecNumber evidence="2">3.2.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_51060</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="2"/>
    <dbReference type="EMBL" id="MU854655">
        <property type="protein sequence ID" value="KAK4032064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P5I7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004352">
        <property type="entry name" value="GH114_TIM-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35273">
        <property type="entry name" value="ALPHA-1,4 POLYGALACTOSAMINIDASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G07890)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35273:SF2">
        <property type="entry name" value="ALPHA-GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03537">
        <property type="entry name" value="Glyco_hydro_114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043007007" description="alpha-galactosidase" evidence="3">
        <location>
            <begin position="19"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside-hydrolase family GH114 TIM-barrel" evidence="4">
        <location>
            <begin position="31"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4032064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="338" mass="36391" checksum="9B63B42F8A636C11" modified="2024-10-02" version="1">MKHASLLAAGLSIQGGLAQVNVPPNFEIGVKWQIIIQNTIDIAAPIQPTDAVVWDLDLYHVARTPGIVDYLRSNNPNAILVCYFNAGLAQTSDCDYDTRWANSGLLGNIYSPDEPEFSDERWVNIKNQTARDWMKQRITLARDFGCDAVDPDNIDGYLNDEDGDNGTGWSLSQDDYVTFVTELATHAHSLTTQQGYTMLIGQKNAPELVEQVGGLLDFAVLEDCKTLNDDEDYTFCSDFQAYIAEGKPVFSIEYPSTLGNQDTGACSATGASDAQYTASCDTTKGNSGFSTVLKIQGGDGELNGCTQYCSGGEPGTGVVVTATDPELDGGECPPEASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P6M3</accession>
    <name>A0AAN6P6M3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-grasp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_51291</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854716">
        <property type="protein sequence ID" value="KAK4031730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P6M3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052032">
        <property type="entry name" value="ATP-dep_AA_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041472">
        <property type="entry name" value="BL00235/CARNS1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43585:SF2">
        <property type="entry name" value="ATP-GRASP ENZYME FSQD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43585">
        <property type="entry name" value="FUMIPYRROLE BIOSYNTHESIS PROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13535">
        <property type="entry name" value="ATP-grasp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18130">
        <property type="entry name" value="ATPgrasp_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="5">
        <location>
            <begin position="211"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4031730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="555" mass="60480" checksum="F313E3F68C0AC956" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P747</accession>
    <name>A0AAN6P747_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cutinase</fullName>
            <ecNumber evidence="3">3.1.1.74</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">C8A01DRAFT_41558</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>cutin + H2O = cutin monomers.</text>
            <dbReference type="EC" id="3.1.1.74"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cutinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.74" evidence="3"/>
    <dbReference type="EMBL" id="MU854663">
        <property type="protein sequence ID" value="KAK4032000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P747"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050525">
        <property type="term" value="F:cutinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000675">
        <property type="entry name" value="Cutinase/axe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011150">
        <property type="entry name" value="Cutinase_monf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48250:SF3">
        <property type="entry name" value="CUTINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48250">
        <property type="entry name" value="CUTINASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01083">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0843">Virulence</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK4032000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="108" mass="11204" checksum="23FE5A93CBCA6F8D" modified="2024-10-02" version="1">MYTFAKLTFRSSMNGYCLDLEDGSGTNCPRVIVIFAGASTEPGNMQGVDGPYLATLANNVFPHQAALTLANTKGPDSAVLAGGYSQDTAVLSNAISELSAEVQAQIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P756</accession>
    <name>A0AAN6P756_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mediator of RNA polymerase II transcription subunit 22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_41556</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854662">
        <property type="protein sequence ID" value="KAK4032015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P756"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009332">
        <property type="entry name" value="Med22"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06179">
        <property type="entry name" value="Med22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="125"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4032015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="159" mass="16768" checksum="A7575B44F7233DC9" modified="2024-10-02" version="1">MDRDATAANNLLERKNILIADIVTSVRDLFSLAIAPVDNTASTGQTAESSMAMETKMSAITKSTEDLVTLSRKIRELWIAGALRAAGADAEPMDPEPGQVFSLLTAIRERQRQGMLQRAAAAGGGFTYEVGGTDGPAPQLQPPEPQVDVTAEGGGVKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P7D5</accession>
    <name>A0AAN6P7D5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 14">DNA replication licensing factor MCM6</fullName>
            <ecNumber evidence="3 14">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">C8A01DRAFT_41807</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the MCM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3 14"/>
    <dbReference type="EMBL" id="MU854710">
        <property type="protein sequence ID" value="KAK4031748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P7D5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097373">
        <property type="term" value="C:MCM core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990518">
        <property type="term" value="F:single-stranded 3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902969">
        <property type="term" value="P:mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17757">
        <property type="entry name" value="MCM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.870:FF:000002">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000003">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1640.10:FF:000009">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000115">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.870">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008049">
        <property type="entry name" value="MCM6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041024">
        <property type="entry name" value="Mcm6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF43">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18263">
        <property type="entry name" value="WHD_MCM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01662">
        <property type="entry name" value="MCMPROTEIN6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 14" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="16">
        <location>
            <begin position="478"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="180"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="819"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="192"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="820"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="830"/>
            <end position="842"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00073495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU368064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAK4031748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="975" mass="105683" checksum="6442D5D8955E84E0" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P884</accession>
    <name>A0AAN6P884_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">BcPKS5, polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">C8A01DRAFT_19501</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854522">
        <property type="protein sequence ID" value="KAK4033573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009403">
        <property type="term" value="P:toxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05930">
        <property type="entry name" value="A_NRPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19532">
        <property type="entry name" value="C_PKS-NRPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000019">
        <property type="entry name" value="Polyketide synthase type I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF20">
        <property type="entry name" value="HYBRID PKS-NRPS SYNTHETASE APDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22621">
        <property type="entry name" value="CurL-like_PKS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="12">
        <location>
            <begin position="8"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="13">
        <location>
            <begin position="970"/>
            <end position="1296"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="11">
        <location>
            <begin position="2497"/>
            <end position="2576"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="11">
        <location>
            <begin position="3756"/>
            <end position="3837"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="9">
        <location>
            <begin position="970"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="9">
        <location>
            <begin position="1126"/>
            <end position="1296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="2610"/>
            <end position="2676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="2610"/>
            <end position="2634"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="9">
        <location>
            <position position="1003"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="9">
        <location>
            <position position="1186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK4033573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="4226" mass="456534" checksum="DB85A33B0CDE8275" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P8J7</accession>
    <name>A0AAN6P8J7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Serine hydrolase FSH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_49783</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LovG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854516">
        <property type="protein sequence ID" value="KAK4033670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P8J7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005645">
        <property type="entry name" value="FSH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050593">
        <property type="entry name" value="LovG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070:SF3">
        <property type="entry name" value="ESTERASE DBAE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03959">
        <property type="entry name" value="FSH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine hydrolase" evidence="3">
        <location>
            <begin position="10"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4033670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="232" mass="25117" checksum="5EB2E554A6C8BB6B" modified="2024-10-02" version="1">MPPPTTTPILLLLHGSGTNADIFRLQSRKLAALLSPHFTLLYLDAPHVCDPGPGVLPFFEGCGPYLTWMDDSTPEKEHDYWAGEQIGRLVGEVRRKGVVGVVGFSMGGKVGMEVVRRLEAEDGEGGCQGGVKIVVAVCGTVPFQGGVDKQGGEDEVKGVRYRESLAKGVVKAQSVHLIGEGDPWRAESEKLVEFFGEEGRRVVRFRGEHHMPVEDALNRQVVRMILAACGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P945</accession>
    <name>A0AAN6P945_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ca2+ regulator and membrane fusion protein Fig1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_39580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854501">
        <property type="protein sequence ID" value="KAK4033970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P945"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000747">
        <property type="term" value="P:conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033481">
        <property type="entry name" value="Dni1/Fig1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28092">
        <property type="entry name" value="FACTOR-INDUCED GENE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28092:SF1">
        <property type="entry name" value="FACTOR-INDUCED GENE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12351">
        <property type="entry name" value="Fig1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4033970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="225" mass="23634" checksum="3D51D3962CC0C48E" modified="2024-10-02" version="1">MKEIYLLSFSYTGSESTVADDTITNPNVSTTVTGLAGNATALQIRVGYFGYCLISGGITSCSTDAASLAALVQGIGWRDSLNLLYVAKAFHNDTIFSGLIFISIIFGFVCFLLLGTFPNWHTETGDDGSEREVKPFPSRPVTQLALLLVSAASLFALVAALWQHLSGAATSTMAGTLMYGTVSGQVGAGAMALGWIATALLFVVMIGLLVMILSISVLAQLTNDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P9I5</accession>
    <name>A0AAN6P9I5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_41287</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854628">
        <property type="protein sequence ID" value="KAK4032271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P9I5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="178"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4032271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="206" mass="22566" checksum="61C0FF3DB49BBAE5" modified="2024-10-02" version="1" fragment="single">MRHRTLLTSALRANAAQLSKHHAPPCAVLTSLSRDLSRTRTAQRRSYTSASPTHRRQHPSTATAAPTTTTILPPATTTNALPPSAANPPPTTRPPPLNLPVRAPNSPRPPFLSPANFSHLLATGVAYLKFYKTGLKHIITNTRLLYSKRPDILAARPHPSTRAYLHLRLRWQHDVRRLPLFALILLVCGEFTPLVVLALPGAVPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P9P5</accession>
    <name>A0AAN6P9P5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EKC/KEOPS complex subunit BUD32</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">Atypical Serine/threonine protein kinase BUD32</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">EKC/KEOPS complex subunit bud32</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">C8A01DRAFT_18867</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. BUD32 has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit KAE1. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="MU854485">
        <property type="protein sequence ID" value="KAK4034309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P9P5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="113"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK4034309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="426" mass="49413" checksum="CED7E82BF13E0337" modified="2024-10-02" version="1">MGYFEEYDLDSRFKSIFSGWNPDNGHYHVVIDWDQRRTISVSTLEEKDEEFVFEALEELIDDLPENVVRIAVSNDFKLLSSSTDVRDDRTAIPFYPSLTDFPPQLPKVRRSQLSEIERLGVHADHTTYEPTPRETKHVVFKYYTNEGNVAMFWHEINCTLRIPHHPNIVPFDRLVVDSATAGGAEMVVGFTTPFIAGGTVSDNVSRVFTLEHLEQLTAAIDYLNLHLGLIHGDISTWNLLIDPSTDRLKIFDFNLGAKLGCSGDQNQDYRGTFAYDKHRNDVKLAVFTLYEIITRDLSFREENHPHELDAAVVLQMEEWERHPDVRLEEGVAVAEYRRVLAEWVNARRERDAEIQHYKQAPDFIDWPSLPEFPLVEWAGSMMRRPSQMRKDMIRRGEPFFKWQRPSTRHLPLPEEQRLLATGEILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P9T3</accession>
    <name>A0AAN6P9T3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Golgi apparatus membrane protein TVP38</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Golgi apparatus membrane protein tvp38</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">C8A01DRAFT_49222</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Golgi membrane protein involved in vesicular trafficking and spindle migration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TVP38/TMEM64 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854482">
        <property type="protein sequence ID" value="KAK4034369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P9T3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051076">
        <property type="entry name" value="Golgi_membrane_TVP38/TMEM64"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="VTT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47549:SF2">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47549">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="VTT_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="110"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="191"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="227"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="VTT" evidence="11">
        <location>
            <begin position="99"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF09335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK4034369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="343" mass="38779" checksum="3622C4DAAAA94000" modified="2024-10-02" version="1">MGDVEPIEMRSQRGSQKLREIDTDYQPVNWKRLFLAPKYLACWILLIIVVVLTVIITIRHDQVVAYLRPWSEKVRDLPAGWLIPIAILIIISFPPLFGHEIIALLCGVVYGLWIGFGIVAAGTFLGELGTWFAFKYLFRRRAEKLERTNLNYGALARLTRDGGFWIVLIIRFSAIPSHFSTAVFATCGVKFWSFAIATFVTLPKQIFLVYLGVLLLQEKADNSAKNIVFGVAFAVTVVMAVYIWYKMRKIKTVLLAEQAERRKARLQSVADDGEAAGREWLMETRQPEGGKVYEEVAQEEADIGVAGAGVHTPPGPHYRADFQYHGAGRTDMGREPMREQTWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P9W3</accession>
    <name>A0AAN6P9W3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dienelactone hydrolase family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_39139</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854481">
        <property type="protein sequence ID" value="KAK4034413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P9W3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630">
        <property type="entry name" value="DIENELACTONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630:SF44">
        <property type="entry name" value="PROTEIN AIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042818043" evidence="1">
        <location>
            <begin position="23"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Dienelactone hydrolase" evidence="2">
        <location>
            <begin position="69"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4034413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="278" mass="29264" checksum="0CDE72C2C17E3368" modified="2024-10-02" version="1" fragment="single">MRTSVLSSALLLVGGAVAGCHGQLSTCQTLDASIVAHTGQPVGQEVKHDNITLYITKPDQKNPRTKARAGKVVLFLTDVFGLALPENKLLADSFARAGYLTVAPDLFAGTPAPGDINVPGFNTTAFLAQHEPPVTDPIIASTLSYVRTELKATRVASPGYCFGGRYAFRFISNSSSSSSGGVGGVDVAFAAHPSLLEADEIAAIGAPVSVAAADRDTLFGADARFAAEKGLLETGEVYQVNLYAGTEHGFGVRVDLGDAQQKYAKEEAFLQAVRWFDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PAI0</accession>
    <name>A0AAN6PAI0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">cyclin-dependent kinase</fullName>
            <ecNumber evidence="1">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_18502</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="1"/>
    <dbReference type="EMBL" id="MU854467">
        <property type="protein sequence ID" value="KAK4034743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PAI0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010389">
        <property type="term" value="P:regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF576">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CSK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="95"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="42"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4034743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="408" mass="44335" checksum="9CB6D3CED1574D15" modified="2024-10-02" version="1">MAEAADWRNALTASERYENIQNITKAIAAAGLSQSAFETENEAYKTANSREEYDEACNPPASGVEPPEPVLTAPSSPPQETNDRESSPGITIGDYQNCHYVASGVTAEVYRAQARALKVIVETHNIEPHNPHREAKILASLRASNAPNIIPLLETFRDPHTQNLVLVFPYAPLTLADLLTSHHPPSSPLPTTLIRPIFTALFHALHHLHSHSLIHRDIKPSALLLTTPEPTSPSQIHLSDFGTAWHPTLSPPSGEPQDSKILDVGTGPYRAPETLFGNRAYGPAIDLWAAGTTLAECFLRKPFFDSRPANEDGNQLGLVLSLFQTLGTPTPESWPEAVGFRTPPFEMYRVFEGRVAREGWEGVAGAGAAAAGWGRLVEGLVRFESGERVTAGEALELPCLKWGEGEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PAU1</accession>
    <name>A0AAN6PAU1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_38560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854459">
        <property type="protein sequence ID" value="KAK4034989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PAU1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4034989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="122" mass="14403" checksum="9BA4881AE04332DF" modified="2024-10-02" version="1">MSAYTYPQMVRYSCHTLYFGHIRKDGWRGGRDHKTFRKVLKEDELCPECERRLEKEMCRTLHWLKRRWEDFTIEVVYIYRNGEEPMTSPEWPLVTESEGTTGSEGVTESEGVTESEGVTESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PAX3</accession>
    <name>A0AAN6PAX3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GH30 family xylanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_48716</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854458">
        <property type="protein sequence ID" value="KAK4034996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PAX3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004348">
        <property type="term" value="F:glucosylceramidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006680">
        <property type="term" value="P:glucosylceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039514">
        <property type="entry name" value="6GAL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033452">
        <property type="entry name" value="GH30_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001139">
        <property type="entry name" value="Glyco_hydro_30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11069">
        <property type="entry name" value="GLUCOSYLCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11069:SF23">
        <property type="entry name" value="LYSOSOMAL ACID GLUCOSYLCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14587">
        <property type="entry name" value="Glyco_hydr_30_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17189">
        <property type="entry name" value="Glyco_hydro_30C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043024843" evidence="4">
        <location>
            <begin position="18"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Endo-beta-1,6-galactanase-like" evidence="5">
        <location>
            <begin position="24"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 30 beta sandwich" evidence="6">
        <location>
            <begin position="373"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4034996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="469" mass="49704" checksum="6B4C1F0BC96642B6" modified="2024-10-02" version="1">MQSLLIALLCAGTAVDAHRQAGSTITVDLSKTYQTIDGFGTSEAFQRAVQMSKLPEAEQRRALDMLFSTTNGAGLSILRNGIGSSPDMSSDHMVSIAPKSPGSPNKPLLYAWDGSDNKQLWVSQEAVHTYGVKTIYADAWSAPGYMKTNGNDANGGTLCGLSGAKCSSGDWRQAYADYLTKYVEFYHQSNVTITHLGFINEPELTASYASMRLSASQAAEFIRILHPTLQKSNLTTKPAIACCDAEGWNSQAGMLGSLRAVDDMLGLVTAHAYTSQPGSPMNTRHPVWQTEAADLQGAWTSAWYSRGGAGEGWTWANNVYQAVVNSNASAYLYWIGVQAGNTNSHMVHIGNNKVEASKRLWALGQWSRFVRPGAVRVGVSGAGGSLRTAGFRNVDGSVAVVVINSGNAARVGVKVAGAASSKAWVTDDTREIGELQAGFADGVASVEVPSRSMATVVLYPSAGGGEAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PB07</accession>
    <name>A0AAN6PB07_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">L-sorbosone dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_19971</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854557">
        <property type="protein sequence ID" value="KAK4033021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PB07"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054539">
        <property type="entry name" value="Beta-prop_PDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH_b-prop"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22807">
        <property type="entry name" value="TrAA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="Soluble quinoprotein glucose dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042858936" evidence="1">
        <location>
            <begin position="24"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="Pyrroloquinoline quinone-dependent pyranose dehydrogenase beta-propeller" evidence="2">
        <location>
            <begin position="35"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4033021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="423" mass="44897" checksum="868FEE3995703529" modified="2024-10-02" version="1">MGHLSTLAGVVALTSMFVPEAAAQSCSGVTGRFQPKMGSGYKSSVLATGLRNPRHIVVDSAGNLLVAEGGTQGVRRLVLQEQGDIVCVQSNTQIASGSTNHGIALSADGKTLFTSNLASVTAYSYDAATGQVGQGKQIVTGMSFQGTHPTRAIATSKWSPDTILVARGSQSNVDTSTTQQSAARSMIKSFSISQGMQTAYNYNTGGEVLAWGLRNIVGMSEDPAFGGFWSVENQMDDIKLNGRDIHNDNPAERLSYHGVLNATENRYKGLNYGYPSCVPAWDPANVGVSGLLVGGLFKPDGVPDVAADECASNRMTGRLHFHAHTAPLDIKFNKNSTAAYIAFHGSWNRNPADGYRVMRVDFANGQPVHAVTSKTAQVPVMENGNISGCPNNCFRPVGLDFDQKGRLFVSSDTSGEIYVIYGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PBL0</accession>
    <name>A0AAN6PBL0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor TFIID subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">TBP-associated factor 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">C8A01DRAFT_18202</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as a component of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854456">
        <property type="protein sequence ID" value="KAK4035074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09839">
        <property type="entry name" value="M1_like_TAF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000011">
        <property type="entry name" value="Transcription initiation factor TFIID subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057345">
        <property type="entry name" value="Ig-like_TAF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037813">
        <property type="entry name" value="TAF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057991">
        <property type="entry name" value="TPR_TAF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15137">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15137:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25316">
        <property type="entry name" value="TAF2_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25577">
        <property type="entry name" value="TPR_TAF2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription initiation factor TFIID subunit 2 Ig-like" evidence="10">
        <location>
            <begin position="606"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription initiation factor TFIID subunit 2 TPR repeats" evidence="11">
        <location>
            <begin position="793"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="263"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1252"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1308"/>
            <end position="1376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1390"/>
            <end position="1501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="263"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="283"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1342"/>
            <end position="1357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1490"/>
            <end position="1501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00076306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF25316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF25577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK4035074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1501" mass="167394" checksum="8D559BFE6D4BBC69" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PCP4</accession>
    <name>A0AAN6PCP4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_47917</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854428">
        <property type="protein sequence ID" value="KAK4038456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PCP4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4038456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="557" mass="63944" checksum="67DD0F8841904226" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PD49</accession>
    <name>A0AAN6PD49_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_17242</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854421">
        <property type="protein sequence ID" value="KAK4038703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PD49"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF24">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="3"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="138"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="156"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4038703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="324" mass="36386" checksum="D46480CA91C345E6" modified="2024-10-02" version="1">MRYCLLNALGIGAFGTVYRARERNTNRVFAVKVLVRREEPWDVALALAYRGEGEILPKLNHSHIIRCFYSHGWGTPRVEIVLTLMDGTLSSLAESPILPRPLLAKHALHQMLQALDYLSQLGYVHRDVKPDNIFYTILPPSRSGPQQPKHHHHHPSTATTNNSNSTMLLPPPPPPPLHFRLGDFGLCEHEAFIEPGEVRGTMLYMAPELFDEDPGRRGRPRPWQRQTHKSDVWALYVTVLWVLDLDGIWRVARRGECSSEGVGFTFTRNLAARVVVDEERVGALREMARVDPWDRVAAGEVLRGLFGGYGGGGGVPGGWVEELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PDP5</accession>
    <name>A0AAN6PDP5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_18402</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854463">
        <property type="protein sequence ID" value="KAK4034853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PDP5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="425"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="487"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="501"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="537"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="614"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="641"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="694"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="750"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="761"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="790"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="875"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1063"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1081"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1105"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1194"/>
            <end position="1206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4034853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1213" mass="129700" checksum="33D5F206641076E7" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PDY3</accession>
    <name>A0AAN6PDY3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Replication factor C subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_47337</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the universal ribosomal protein uL16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854409">
        <property type="protein sequence ID" value="KAK4039131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PDY3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031391">
        <property type="term" value="C:Elg1 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031389">
        <property type="term" value="C:Rad17 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01433">
        <property type="entry name" value="Ribosomal_L16_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1170.10:FF:000003">
        <property type="entry name" value="54S ribosomal protein L16, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000030">
        <property type="entry name" value="replication factor C subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000002">
        <property type="entry name" value="Replication factor C subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000136">
        <property type="entry name" value="Replication factor C subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.10">
        <property type="entry name" value="Ribosomal protein L10e/L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047873">
        <property type="entry name" value="Ribosomal_uL16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000114">
        <property type="entry name" value="Ribosomal_uL16_bact-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020798">
        <property type="entry name" value="Ribosomal_uL16_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016180">
        <property type="entry name" value="Ribosomal_uL16_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036920">
        <property type="entry name" value="Ribosomal_uL16_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01164">
        <property type="entry name" value="rplP_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF1">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13177">
        <property type="entry name" value="DNA_pol3_delta2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21960">
        <property type="entry name" value="RCF1-5-like_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22534">
        <property type="entry name" value="RFC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00252">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00060">
        <property type="entry name" value="RIBOSOMALL16"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54686">
        <property type="entry name" value="Ribosomal protein L16p/L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00701">
        <property type="entry name" value="RIBOSOMAL_L16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="9">
        <location>
            <begin position="280"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00070185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4039131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="598" mass="66629" checksum="80D220DBBA961887" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PDZ5</accession>
    <name>A0AAN6PDZ5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_47258</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854406">
        <property type="protein sequence ID" value="KAK4039234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PDZ5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="565"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="576"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4039234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="596" mass="66306" checksum="F09CBF53201EF423" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PE84</accession>
    <name>A0AAN6PE84_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">C8A01DRAFT_36769</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the U5 snRNP complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family. DDX23/PRP28 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="MU854405">
        <property type="protein sequence ID" value="KAK4039281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PE84"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17945">
        <property type="entry name" value="DEADc_DDX23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000322">
        <property type="entry name" value="probable ATP-dependent RNA helicase DDX23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057479">
        <property type="entry name" value="PRP28/DDX23-like_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25430">
        <property type="entry name" value="DDX23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 14 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="18">
        <location>
            <begin position="274"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="305"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="519"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="18"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="673"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="13">
        <location>
            <begin position="274"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="65"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="674"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="701"/>
            <end position="710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAK4039281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="710" mass="79235" checksum="35F256270296D94F" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PF02</accession>
    <name>A0AAN6PF02_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_16343</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854394">
        <property type="protein sequence ID" value="KAK4039701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PF02"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015165">
        <property type="term" value="F:pyrimidine nucleotide-sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007271">
        <property type="entry name" value="Nuc_sug_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012404">
        <property type="entry name" value="UCP036436"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13146">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13146:SF0">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER F6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04142">
        <property type="entry name" value="Nuc_sug_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036436">
        <property type="entry name" value="UCP036436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="290"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="87"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="105"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4039701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="432" mass="47405" checksum="377E68241949B376" modified="2024-10-02" version="1">MATTIIPARAIIPFLVGMMLLTGVCNTLLTKYQDNQCVRDCDNSDPKKRRHFEQPVFQTLQMFVGEMGCWLVVGLMSLYRRYTSPSQSTATYQPIPATDTENDNDTNPRTASDNASIHSTTALNPSPSTDCSTPHKQHDCPSVLRGWRVTLLALPAVCDILATTLMNAGLLLVAASIYQMTRGALVLFVGLFSVVFLRRHLHAFQWLSLVGVMVGVGIVGLAGAIQPDKKPGGVAPEAGGDVSADAVMVIVGVLMIAGAQIFTATQFVLEEWILERSAIEPIRVVGWEGVFGFTVTLLGMVVLHAVIGRTEAGRYGPFDMVEGWRQFWEHEAVFVSSVLIMISIGGFNFFGLSVTRSVSATSRSTIDTCRTLFIWIVSLGLGWETFKWLQVVGFVLLVYFTFLFNGIVQPPLAFLRVGEVEELLPEEPIEHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PF48</accession>
    <name>A0AAN6PF48_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Prefoldin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_18038</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854450">
        <property type="protein sequence ID" value="KAK4035271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PF48"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990113">
        <property type="term" value="P:RNA polymerase I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990114">
        <property type="term" value="P:RNA polymerase II core complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990115">
        <property type="term" value="P:RNA polymerase III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23157">
        <property type="entry name" value="Prefoldin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000004">
        <property type="entry name" value="Probable prefoldin subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011599">
        <property type="entry name" value="PFD_alpha_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004127">
        <property type="entry name" value="Prefoldin_subunit_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00293">
        <property type="entry name" value="prefoldin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12674">
        <property type="entry name" value="PREFOLDIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12674:SF2">
        <property type="entry name" value="PREFOLDIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02996">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4035271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="163" mass="17229" checksum="7AC3FE8C03FFA361" modified="2024-10-02" version="1">MASRGGQQQQGEAVDLGTLSAQQLSAVKKQLDGEVEHLSSSYAQLAAAQAKFKECLRVVKSGSSSFDKTKSILVPLTNSLYVKGQLADPDRVLVDVGTGFYVEKDTKSASDFYEAKVKELAGNIQGLEGIVQAKTNNLRVVEEVLRQKVLAQGQGAGAGGQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2025-10-08" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PF77</accession>
    <name>A0AAN6PF77_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nucleoporin NUP188</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">C8A01DRAFT_38619</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the Nup188 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854461">
        <property type="protein sequence ID" value="KAK4034922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044611">
        <property type="term" value="C:nuclear pore inner ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018864">
        <property type="entry name" value="Nucleoporin_Nup188_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044840">
        <property type="entry name" value="Nup188"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041634">
        <property type="entry name" value="Nup188_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048883">
        <property type="entry name" value="Nup188_N-subdom_III"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31431:SF1">
        <property type="entry name" value="NUCLEOPORIN NUP188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31431">
        <property type="entry name" value="NUCLEOPORIN NUP188 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18378">
        <property type="entry name" value="Nup188_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10487">
        <property type="entry name" value="Nup188_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21093">
        <property type="entry name" value="Nup188_N-subdom_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21094">
        <property type="entry name" value="Nup188_SH3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup188 N-terminal" evidence="10">
        <location>
            <begin position="178"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin Nup188 N-terminal subdomain III" evidence="12">
        <location>
            <begin position="710"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="domain" description="Nuclear pore protein Nup188 C-terminal" evidence="11">
        <location>
            <begin position="1454"/>
            <end position="1818"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF10487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF21093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK4034922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1823" mass="200531" checksum="A960FE561318FF79" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PF79</accession>
    <name>A0AAN6PF79_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Bestrophin, RFP-TM, chloride channel-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_37205</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854417">
        <property type="protein sequence ID" value="KAK4038880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PF79"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044669">
        <property type="entry name" value="YneE/VCCN1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281">
        <property type="entry name" value="UPF0187 PROTEIN YNEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281:SF19">
        <property type="entry name" value="VOLTAGE-DEPENDENT ANION CHANNEL-FORMING PROTEIN YNEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25539">
        <property type="entry name" value="Bestrophin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="352"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="492"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4038880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="515" mass="56471" checksum="03BCB97DE535D0E0" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PF98</accession>
    <name>A0AAN6PF98_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-chaperonin molecular chaperone ATPase</fullName>
            <ecNumber evidence="2">3.6.4.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_16226</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.10" evidence="2"/>
    <dbReference type="EMBL" id="MU854390">
        <property type="protein sequence ID" value="KAK4039858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PF98"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000172">
        <property type="entry name" value="Heat shock 70 kDa protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000014">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000026">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000004">
        <property type="entry name" value="Heat shock protein SSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000005">
        <property type="entry name" value="Heat shock protein ssb1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0346">Stress response</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4039858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="615" mass="66804" checksum="9C66522B335BA856" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PFE3</accession>
    <name>A0AAN6PFE3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome b5-like heme/steroid binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_38524</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cytochrome b5 family. MAPR subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854458">
        <property type="protein sequence ID" value="KAK4035012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PFE3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000003">
        <property type="entry name" value="membrane-associated progesterone receptor component 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050577">
        <property type="entry name" value="MAPR/NEUFC/NENF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281">
        <property type="entry name" value="MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281:SF72">
        <property type="entry name" value="NEUDESIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="8">
        <location>
            <begin position="63"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4035012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="174" mass="19259" checksum="43A4DE424E9886FA" modified="2024-10-02" version="1">MDYVQQRVAQAASSTDPSSTALFTPLNALLLSVLLYTTYTFLLRPSPPPQLPKEQPAVVFRTFTPRTLLPYNGENDMPVYLAVRGRVFDVTRGRNFYGPGGPYANFAGRDASRGLACGSFDEEMLTKDLDGPLDKLEGLGGEEMEALRGWEERFEEKYLVVGKLVAVGEEGKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PFX2</accession>
    <name>A0AAN6PFX2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aggrecan core protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_37547</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854427">
        <property type="protein sequence ID" value="KAK4038491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PFX2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042883040" description="Aggrecan core protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4038491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="619" mass="64373" checksum="EBC70CF3AE2FB646" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PFY8</accession>
    <name>A0AAN6PFY8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Fungal-specific transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_48129</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854435">
        <property type="protein sequence ID" value="KAK4038249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PFY8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF45">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
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        <location>
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            <end position="64"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
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            <end position="23"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="124"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
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            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4038249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="812" mass="89628" checksum="C6DC723AB3F39A6A" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PGH3</accession>
    <name>A0AAN6PGH3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_15831</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854380">
        <property type="protein sequence ID" value="KAK4040292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PGH3"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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            <end position="71"/>
        </location>
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            <end position="42"/>
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            <end position="64"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <end position="567"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK4040292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="597" mass="65708" checksum="C9BF4378D4EFF0D1" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854425">
        <property type="protein sequence ID" value="KAK4038579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050251">
        <property type="entry name" value="HpcH-HpaI_aldolase"/>
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    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
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    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30502">
        <property type="entry name" value="2-KETO-3-DEOXY-L-RHAMNONATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30502:SF8">
        <property type="entry name" value="SYNTHASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
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    </dbReference>
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        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HpcH/HpaI aldolase/citrate lyase" evidence="3">
        <location>
            <begin position="45"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4038579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="298" mass="32580" checksum="1D5A85EEB96BD7E0" modified="2024-10-02" version="1">MAFPSLVPGDSEGMKAYMGPSLFQPHRARQAIRDAHEKKIPPLIGYYAGLSSVPITRFLAPMGYDAVWIDWEHTSCNVETMTTMVHETMFMSGGRTIPFVRVPGHDHAAIGFALDAGASIVIPQLETVEQAKHVVSSAKFGTRQNGTRSAPPFRMVPGLTDMAADGKRDVWRNLNDQAAIMVQIETLEGINNLDAILTEVPDIDVVWLGTLDCRISMNLPGNFGMGGNEPEWLAAVEKFDATLKKHNKPRAGFSLGGGEELTKMGQDHVLLLHAADVMKLYEMGPQLLAARQAVAFKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PGP3</accession>
    <name>A0AAN6PGP3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription initiation factor TFIID subunit 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_17048</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Functions as a component of both the DNA-binding general transcription initiation factor complex TFIID and the transcription coactivator SAGA complex. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription. SAGA acts as a general cofactor required for essentially all RNA polymerase II transcription. At the promoters, SAGA is required for transcription pre-initiation complex (PIC) recruitment. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction (via core/TAF module) and promoter selectivity, interaction with transcription activators (via Tra1/SPT module), and chromatin modification through histone acetylation (via HAT module) and deubiquitination (via DUB module). SAGA preferentially acetylates histones H3 (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac) and H2B and deubiquitinates histone H2B. SAGA interacts with DNA via upstream activating sequences (UASs).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the TAF10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854416">
        <property type="protein sequence ID" value="KAK4038896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PGP3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990841">
        <property type="term" value="F:promoter-specific chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07982">
        <property type="entry name" value="HFD_TAF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003923">
        <property type="entry name" value="TAF10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21242">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21242:SF0">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03540">
        <property type="entry name" value="TAF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017246">
        <property type="entry name" value="TFIID_TAF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="135"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR017246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4038896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="202" mass="21136" checksum="56E02BB3BDE176C5" modified="2024-10-02" version="1">MAANPPTANAEQVTAPAVNPNGAQPNETAGANADATAVPLAPETRLPTRKDASLKEFLNKMDDYAPIIPDAVTNYYMTRAGLPPPPQTDQRLARLLALATQKFIADIAADAYQYSRIRASNTSANNPMGNLGAAAGFPIPGQPANQPGNKDQGRGGPLGIQRPGYGGGGQGGSQNRTVLTMEDLGMAVGEFGVNVKRSEFYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PGU5</accession>
    <name>A0AAN6PGU5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_35626</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat PROPPIN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854378">
        <property type="protein sequence ID" value="KAK4040392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PGU5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048720">
        <property type="entry name" value="PROPPIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11227">
        <property type="entry name" value="WD-REPEAT PROTEIN INTERACTING WITH PHOSPHOINOSIDES WIPI -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21032">
        <property type="entry name" value="PROPPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="251"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="263"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4040392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="400" mass="42718" checksum="D4E478CED0ECBC88" modified="2024-10-02" version="1">MNTRTPLESPSATVVLSISFNDDCSRFAVGLNTGFCILDADTCLLRETRDFNAGVGLVQMMGKANYVGLVGGGRQPKFAANKLIIWDDLKSKAALEISALTPVRGAQLSKEHIVVVLQNSVRVYRFAKPPNLLSAYETANNPWGLCCLSPKRIAFPGRTTGHVQLVEIATGNVSIIPAHTSAVKAIQLSPDGELLATASETGTLIRVFSTSNCARLVELRRGIDPATIFSLAFNPSGTMLACTSDKSTLHIFDVPHPRRPSRQQQQQQQLQQQQNGGNGGPSDTTTGADGRGKWGILSKIPMMPRMFSDVYSIASARFAADDDVEGAGAGGVVGGLPVSESTTLGTSKPPKGVIGWVGEDALLVVGAGKDARWEKFVVQEGSDGRRHCVREGWKRYLAGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PH27</accession>
    <name>A0AAN6PH27_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">20S-pre-rRNA D-site endonuclease NOB1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">C8A01DRAFT_45870</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for the synthesis of 40S ribosome subunits. Has a role in processing 20S pre-rRNA into the mature 18S rRNA, where it is required for cleavage at the 3' end of the mature 18S rRNA (D-site). Accompanies the 20S pre-rRNA from the nucleus to the cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
            <location evidence="7">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the NOB1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854368">
        <property type="protein sequence ID" value="KAK4040848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PH27"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09876">
        <property type="entry name" value="PIN_Nob1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000020">
        <property type="entry name" value="20S-pre-rRNA D-site endonuclease NOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.210.10">
        <property type="entry name" value="Nin one binding (NOB1), Zn-ribbon-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039907">
        <property type="entry name" value="NOB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017117">
        <property type="entry name" value="Nob1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036283">
        <property type="entry name" value="NOB1_Zf-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014881">
        <property type="entry name" value="NOB1_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033411">
        <property type="entry name" value="Ribonuclease_PIN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12814">
        <property type="entry name" value="RNA-BINDING PROTEIN NOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12814:SF2">
        <property type="entry name" value="RNA-BINDING PROTEIN NOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17146">
        <property type="entry name" value="PIN_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08772">
        <property type="entry name" value="Zn_ribbon_NOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037125">
        <property type="entry name" value="D-site_20S_pre-rRNA_nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144206">
        <property type="entry name" value="NOB1 zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Ribonuclease PIN" evidence="11">
        <location>
            <begin position="48"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Nin one binding (NOB1) Zn-ribbon-like" evidence="10">
        <location>
            <begin position="312"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="148"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="233"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="434"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="26"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="237"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="337"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR037125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR037125-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK4040848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="463" mass="50427" checksum="F1AFD046C82EBA32" modified="2024-10-02" version="1">MEQQASEPAVQAPTEDQNPAPTMPDTTESAPAPSTSTPATPSKPVHSLVIDANAIIKNDPTVSTLLAQAEELYTIPAVVSEIRDEATRSRFQTTLSPFLKLRTPRPESVEFVTSFARRTGDLQVLSKPDLHLLALTYDLEVERNGGDWRLRREPNQKGVNGRPPGKTEDEAGEATTTETQEKADGEPSTTTSDPAKEQEDVVPEAADAASPSDEVTSESVTEALQDLSLNQAAVEEGTPEDEGASTEDDDDGAGEWITPSNIKKYQARENAHTDPNPVQRVLQAALITGDMAMRNVALRINLNLLDSGFSRITYLKTWVLRCHGCFKVCRDMSKQFCPSCGQPTLTRVSCSTDAGGNFTLHLKKNFQYNNRGNVFSIPKPTHGSASGKGNNAKGGGKNGWGKELILAEDQKEYTKKLDEERRTKYRDLMDQDYLPSILGGSRNSGSGRIKVGAGRNVNAKKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PHF9</accession>
    <name>A0AAN6PHF9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_15372</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854369">
        <property type="protein sequence ID" value="KAK4040817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PHF9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051165">
        <property type="entry name" value="Multifunctional_ANK_Repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123:SF33">
        <property type="entry name" value="PROTEIN HOS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="492"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="525"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="558"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="596"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="629"/>
            <end position="661"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4040817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="736" mass="79263" checksum="72112045998F9573" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PHL1</accession>
    <name>A0AAN6PHL1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_15122</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854363">
        <property type="protein sequence ID" value="KAK4041118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PHL1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042940973" evidence="2">
        <location>
            <begin position="23"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="275"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4041118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="298" mass="30254" checksum="61A91F6BE4C3BD06" modified="2024-10-02" version="1">MGITTAALRLLALLLLAVLAAAQSSSPSSSPPAQTSSSPPGSSTSTRTSTLTTTTRGGTLPPLPTGSSPPDVLLRVPELHVGKIELDVDNLRADLNLNAEIANLVSLNVGVQVGVSKVNITIADVDAQLDLVIRLGNLAKMVNRTLASLDLNPLLINLLNEVGDAVDSVVGAVDGLLGSILSGDTKLSFLIDNLGNIVQEVVEGAGEVVSSIVGNYEKNMTYTGISKDLGNGLRQKTYRYDALGSLVNIIFNTLGQVVQAVVVGKDNSGGGGGSSSTSALPTSTASASGAARSGTRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PHV3</accession>
    <name>A0AAN6PHV3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Alpha/beta knot methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">C8A01DRAFT_45755</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854365">
        <property type="protein sequence ID" value="KAK4041027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PHV3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070037">
        <property type="term" value="F:rRNA (pseudouridine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18088">
        <property type="entry name" value="Nep1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1280.10:FF:000003">
        <property type="entry name" value="Ribosomal RNA small subunit methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005304">
        <property type="entry name" value="Rbsml_bgen_MeTrfase_EMG1/NEP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12636">
        <property type="entry name" value="NEP1/MRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12636:SF5">
        <property type="entry name" value="RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE NEP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03587">
        <property type="entry name" value="EMG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="8" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK4041027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="261" mass="28955" checksum="7B19793A1FF3F59F" modified="2024-10-02" version="1">MSSSPEYRAGKRPRTQSLPPPELPQLVAEQHTPIPPTDKDSKRLIVVLSNASLETYKASHGGVNRMGVQREEKYSLLNSDEHIGVMRKMNRDISDARPDITHQCLLTLLDSPINKAGKLQIYIQTAKGVLIEVSPSVRIPRTFKRFAGLMVQLLHRLSIKGTNSQEKLLKVIQNPITDHLPPNCRKITLSFDAPMVRVRDYIDTLGANESICVFVGAMAKGADNFADAYVDEKISISNFSLSASVACSKFCHAAEDCWDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PI05</accession>
    <name>A0AAN6PI05_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_46276</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854378">
        <property type="protein sequence ID" value="KAK4040380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PI05"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015123">
        <property type="term" value="F:acetate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051633">
        <property type="entry name" value="AceTr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000791">
        <property type="entry name" value="Gpr1/Fun34/SatP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123:SF4">
        <property type="entry name" value="PROTEIN ALCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01184">
        <property type="entry name" value="Gpr1_Fun34_YaaH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4040380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="279" mass="30653" checksum="F5649BB9783E2FE7" modified="2024-10-02" version="1">MTTAEPATASNGIRMVGDEEKGLYRTQTGVTMSPELFEKLYLTPKVPQVGDYNRRFANPTALGFVGFVISTFTFSIICMGWGGAQGFSPVVGIFFFVGPVLLTFAMVFEWVMGNFFPMMVMGLFSVFWSSFGMLQLPTLQLGAPYATAADPTGLASPGYNSAVAVYLLVWGFALFTFFIFTCKINAVFAAIFLLVSVAAWVLSGAYWKVSWGDYEEAARLQKGGGALLFVVAALGWYMCFIIMAGEMRITLNLPVGDLSHLWPRTDVELAATERREHKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PI37</accession>
    <name>A0AAN6PI37_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NECAP PHear domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_45443</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854358">
        <property type="protein sequence ID" value="KAK4041379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PI37"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030125">
        <property type="term" value="C:clathrin vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012466">
        <property type="entry name" value="NECAP_PHear"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12847">
        <property type="entry name" value="ATP-BINDING CASSETTE ABC TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12847:SF9">
        <property type="entry name" value="NECAP-LIKE PROTEIN CG9132"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07933">
        <property type="entry name" value="DUF1681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NECAP PHear" evidence="2">
        <location>
            <begin position="21"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4041379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="289" mass="30493" checksum="EA3226E22B42AA4F" modified="2024-10-02" version="1">MDSSATMDPATGRPLPPDAIVRILHITTKVHVYSLPRDAVSTTAGYAAASWTTDPRNHIFTARLRVLETSFTSPSPTTPTSSTTAEDTEPEPQIKVDILLEDPSTGSLFAAAPYTAPATVEPTTDSSRFFAVRVQDPSSKQKATLGVGFEERSEAFDFGVALQEAGRALNWAGPGSSSAQGGAGNQGGVGWKAAGASKGGWEEKEEEKRDLSLKEGETITVNLAGTRFGRRAGRAESQGERKEGEGGGQSLASFALPPPPPPSAREVRAQKRLSAQQLGFDDGQFGEFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PI75</accession>
    <name>A0AAN6PI75_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_45381</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854357">
        <property type="protein sequence ID" value="KAK4041418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PI75"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF16">
        <property type="entry name" value="GPI INOSITOL-DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NACHT" evidence="3">
        <location>
            <begin position="485"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="289"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1254"/>
            <end position="1273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="316"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1262"/>
            <end position="1273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4041418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1273" mass="141918" checksum="D08F471EA8370990" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PJW9</accession>
    <name>A0AAN6PJW9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_14799</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854357">
        <property type="protein sequence ID" value="KAK4041428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PJW9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4041428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="303" mass="32145" checksum="10C790D1CAC98F62" modified="2024-10-02" version="1">MPLSLSSADKIASYGIRGADPSPSFLAIELSQAVHRISLINAWDPAIGPGTRVLELGCGQGTCTQALAEAVSSPEDATGSGHGHITAVDPGHPDYGAPFTLAQAQAHLSAGPLGPLVTFHRADPVGFLAANPDTQWDVAVLAHCIWYFRSPDTLRQILWALRGRVARVCLAEWALHATEPAATAHVLAALARATFEAHRVGSRENIQTLASPRAIREAVGQAGWKVETEGTVVPDAELSDGFWETGTVVRKEFAEEVEKEIKEERVKAVLASARDATTAAADSVGGVKRVRSMDVWAATLIPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PK41</accession>
    <name>A0AAN6PK41_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Alcohol dehydrogenase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_44812</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854345">
        <property type="protein sequence ID" value="KAK4042162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PK41"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08290">
        <property type="entry name" value="ETR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051034">
        <property type="entry name" value="Mito_Enoyl-ACP_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43981">
        <property type="entry name" value="ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43981:SF2">
        <property type="entry name" value="ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="8">
        <location>
            <begin position="313"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="128"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="164"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4042162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="508" mass="54862" checksum="0A3FF9D1C7C4B767" modified="2024-10-02" version="1">MPSQTNPTAAPTGTTKTKRFELPALNLKFGSLTDGTDIPPPLPSPIQEEAAPTPPDTPKGAQQKQEGKDAANGKANTASPNSRVSSISTAGTKRRAEDGPASPTLSSRPGSIRRLFSRSLLNTAYANGNESAQDGRPQSRGSASVVDSRKAKRSSGWFGRLRSNESVPSQTATPLSPPATDEKKPTGPPPPMIPELSELNTKLGIQTDNGFGGDFFKDINSWRRYKSGPYGYTQAKALVFSRFGEPRDVLALHTHSISPSLPRGAALLRALAAPVNPADVNTIQGTYGARPSFDQQQLALGTPEPAANGANSGVGRAAIQFGRLWGLRSINVVRERATPEETEALKSELTELGATVVVTESEFLDRSFTARLKEEWTRGGREPVMLGLNCVGGKSASAMVKALSPKGCMVTYGGMSRQSFPFPTGPQIFKRLRFEGFWLSEWGKENPLEKRNTVNEILDLMREGKFKEAPFKEVEWNWDTEEKVLKDAVQGTLEGFRGGKGLFVFGET</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PKF2</accession>
    <name>A0AAN6PKF2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bms1-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_33676</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TRAFAC class translation factor GTPase superfamily. Bms1-like GTPase family. TSR1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854343">
        <property type="protein sequence ID" value="KAK4042327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PKF2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000479">
        <property type="term" value="P:endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012948">
        <property type="entry name" value="AARP2CN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039761">
        <property type="entry name" value="Bms1/Tsr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007034">
        <property type="entry name" value="BMS1_TSR1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030387">
        <property type="entry name" value="G_Bms1/Tsr1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858:SF1">
        <property type="entry name" value="PRE-RRNA-PROCESSING PROTEIN TSR1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08142">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04950">
        <property type="entry name" value="RIBIOP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22298">
        <property type="entry name" value="Tsr1_G-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00785">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01362">
        <property type="entry name" value="DUF663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51714">
        <property type="entry name" value="G_BMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Bms1-type G" evidence="6">
        <location>
            <begin position="88"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="322"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="389"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="31"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="403"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4042327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="825" mass="92144" checksum="D671C088FD52427B" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PKP4</accession>
    <name>A0AAN6PKP4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TBP-associated factor 6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Transcription initiation factor TFIID subunit 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_35147</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854368">
        <property type="protein sequence ID" value="KAK4040876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PKP4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046695">
        <property type="term" value="C:SLIK (SAGA-like) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22931">
        <property type="entry name" value="HFD_TAF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08050">
        <property type="entry name" value="TAF6C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000033">
        <property type="entry name" value="Transcription initiation factor TFIID complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.770">
        <property type="entry name" value="TAF6, C-terminal HEAT repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037796">
        <property type="entry name" value="TAF6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011442">
        <property type="entry name" value="TAF6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046344">
        <property type="entry name" value="TAF6_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004823">
        <property type="entry name" value="TAF_TATA-bd_Histone-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10221">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10221:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02969">
        <property type="entry name" value="TAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07571">
        <property type="entry name" value="TAF6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00803">
        <property type="entry name" value="TAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TATA box binding protein associated factor (TAF) histone-like fold" evidence="8">
        <location>
            <begin position="10"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00076308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00093655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4040876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="474" mass="51413" checksum="9E9E36D37667CA43" modified="2024-10-02" version="1">MAANDGPKLLWNPDNVRDVADSIGISLSDEPLRVLAQDVEYRIGQVIVEALRFMRAANRTTLTVQDVSQALKVLDVEPLYGYESTRPLRYGEASLGPGQPLFYIDDEEVDFEKVINAPLPKVPRDMSFTAHWLAVEGVQPSIPQNPTTAETSSKDLLPKGPGANPALAALAGNDNVSFRPSVKHVISKELILYFDKIQAAVLDDDPDEEKTRLREAALESVRSDPGLHQLLPYFVNFITNQVTHHLDDLFILRQMMELAEAVIQNSNLFLDPYASALSAPVLTCLMSRKLGGGSGSGSGAADDGGSDTLREQYNLRELAASLLEMVARKYGATNALLRPKLTRTCLKHFLDPTRPPAVLFGAIRGVAASGGPEAVRVLVLPNMKSFDGAVLQPLRDRGEAHAMELEMLVGGIMKAVETLVGGSGIPVANGVNGVDLSREGEQVVEFLGPIIGRRVARLGNHALNRAILEVRHLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PKT7</accession>
    <name>A0AAN6PKT7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Glucose-6-phosphate 1-dehydrogenase</fullName>
            <ecNumber evidence="3 11">1.1.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">C8A01DRAFT_44422</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5-lactone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15841"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="1.1.1.49"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glucose-6-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.49" evidence="3 11"/>
    <dbReference type="EMBL" id="MU854339">
        <property type="protein sequence ID" value="KAK4042537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PKT7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004345">
        <property type="term" value="F:glucose-6-phosphate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009051">
        <property type="term" value="P:pentose-phosphate shunt, oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000015">
        <property type="entry name" value="Glucose-6-phosphate 1-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000111">
        <property type="entry name" value="Glucose-6-phosphate 1-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00966">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001282">
        <property type="entry name" value="G6P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019796">
        <property type="entry name" value="G6P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022675">
        <property type="entry name" value="G6P_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022674">
        <property type="entry name" value="G6P_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00871">
        <property type="entry name" value="zwf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429:SF0">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02781">
        <property type="entry name" value="G6PD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00479">
        <property type="entry name" value="G6PD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000110">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00079">
        <property type="entry name" value="G6PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00069">
        <property type="entry name" value="G6P_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 11" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="6 11" id="KW-0521">NADP</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-6-phosphate dehydrogenase NAD-binding" evidence="12">
        <location>
            <begin position="21"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-6-phosphate dehydrogenase C-terminal" evidence="13">
        <location>
            <begin position="200"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK4042537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="508" mass="58331" checksum="DA14BC34957FBD1C" modified="2024-10-02" version="1">MASSDLHSAGSVELKENTVIVVLGASGDLAKKKTFPALFGLYRNQFLPKDIKIVGYARTKMDHDEYLRRIKSYIKTPTKDIEQQLEEFCNLCTYVSGQYDRDESFLQLNKHLEELEQGRKETNRLFYMALPPSVFTIVSQHLKKCCYPSKGIARVIVEKPFGKDLASSRELQKSLEPDWKEDELFRIDHYLGKEMVKNILILRFGNSFLGATWNRHHIDNVQITFKEPFGTEGRGGYFDEFGIIRDVMQNHLLQVLTLLAMERPISFSSEDIRDEKVRVLRAIPAIEPKNVIIGQYGKSLDGSKPSYKEDDTVPKDSRCPTFCALVAYIKNERWDGVPFIMKAGKALNEQKTEIRVQFKDVTSGIFKDIPRNELVMRIQPNESVYIKMNSKLPGLTMQTVVTELDLTYRRRFSDLKIPEAYESLILDCLKGDHSNFVRDDELDASWRIFTPLLHYLDDNKEIIPMEYPYGSRGPAVLDDFTSSYGYKFSDAAGYQWPTTSALNPGNKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PL62</accession>
    <name>A0AAN6PL62_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_35417</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854374">
        <property type="protein sequence ID" value="KAK4040555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PL62"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4040555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="163" mass="17108" checksum="1958D5EC93E274BC" modified="2024-10-02" version="1">MASPQENSEPSNSNDNSTHLIESLDGESRVQDALEREAPTTVRGAVSAAAFIIYVCTIMAYISLSPQGPGQGQDRFKVARLVAVAVWMVDSGVLFLCHARYLIRREIASAFLISALGLHYFVGAGGFGIADGVGVIMMCIVVAVLCPGLLGTMGMMGPGSAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PLP8</accession>
    <name>A0AAN6PLP8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_45630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854362">
        <property type="protein sequence ID" value="KAK4041191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PLP8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="194"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="559"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="341"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="416"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="439"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="456"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="492"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4041191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="609" mass="66860" checksum="E6DA43377F6F46FA" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PLV9</accession>
    <name>A0AAN6PLV9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1996 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_43585</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854327">
        <property type="protein sequence ID" value="KAK4043458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PLV9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018535">
        <property type="entry name" value="DUF1996"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662:SF7">
        <property type="entry name" value="DUF1996 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09362">
        <property type="entry name" value="DUF1996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1996" evidence="2">
        <location>
            <begin position="34"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="399"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4043458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="486" mass="52716" checksum="8284394EBB5D8607" modified="2024-10-02" version="1">MRVDSSLAILASVSGAAAFWRMECRGLGALARLDPLIDPGVASQHAHAIHGSSGFNSDATYEDLVNGDCTSCAVAEDKSAYWAPAVYFKHANGTYQEVLQDGGMLAYYFLNYDLKDTTKGIKAFPNNFRMIAGDSSRRNYSVGGLDFLLPDPPKSNWASMGQTNQADLRQRAIGFNCLNYDTDPEPTLYRHYMPDKAFLDAKCKHGVRFELSFPSCWNGKDTSSPDHKSHVAYPDTVLNGDCPEGFDVKLPGLMFETIWRTHDFVGVPGEFVISNGDVSGFGYHGDFISGWDENLLQAAVEQCTNGSGLLSDCPLFTLISADEQRKCKIPAPPMIASEKLAGIIGNVLPGGVEIQYGPAPAVHKKPEIALPSISLPAPNVLPGGVFQEQPTSTPEVQEVPEPTSTSTPTPTPTPIPSDPPVPEGYELVRTDYVTNGNVVSKIVVIETVEYVMVATETVTVTATPGADKARREVQHLHLHRHRHGAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PMH4</accession>
    <name>A0AAN6PMH4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acetyl-coenzyme A transporter 1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_12701</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854324">
        <property type="protein sequence ID" value="KAK4043764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PMH4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008521">
        <property type="term" value="F:acetyl-CoA transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035348">
        <property type="term" value="P:acetyl-CoA transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000289">
        <property type="entry name" value="Acetyl-coenzyme A transporter 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024371">
        <property type="entry name" value="AcetylCoA_trans_1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004752">
        <property type="entry name" value="AmpG_permease/AT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12778:SF9">
        <property type="entry name" value="ACETYL-COENZYME A TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 33 ACETYL-COA TRANSPORTER -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13000">
        <property type="entry name" value="Acatn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="389"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="420"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="458"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="534"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4043764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="580" mass="63775" checksum="503524D2EC796698" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PMY9</accession>
    <name>A0AAN6PMY9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Prion-inhibition and propagation-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_33088</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854335">
        <property type="protein sequence ID" value="KAK4042838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PMY9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1020">
        <property type="entry name" value="Prion-inhibition and propagation, HeLo domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056002">
        <property type="entry name" value="DUF7580"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029498">
        <property type="entry name" value="HeLo_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038305">
        <property type="entry name" value="HeLo_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37542">
        <property type="entry name" value="HELO DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37542:SF3">
        <property type="entry name" value="PRION-INHIBITION AND PROPAGATION HELO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24476">
        <property type="entry name" value="DUF7580"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14479">
        <property type="entry name" value="HeLo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0034">Amyloid</keyword>
    <keyword evidence="2" id="KW-0640">Prion</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="257"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4042838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="614" mass="68025" checksum="569825C9F55ECE03" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PN20</accession>
    <name>A0AAN6PN20_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">LMBR1-like membrane protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_31879</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LIMR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854322">
        <property type="protein sequence ID" value="KAK4044006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PN20"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051584">
        <property type="entry name" value="GPCR-associated_LMBR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006876">
        <property type="entry name" value="LMBR1-like_membr_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21355">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR-ASSOCIATED PROTEIN LMBRD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21355:SF0">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR-ASSOCIATED PROTEIN LMBRD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04791">
        <property type="entry name" value="LMBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="14"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="359"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="411"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="453"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="500"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="572"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="688"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="209"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="579"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="614"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="628"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="719"/>
            <end position="729"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4044006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="736" mass="80370" checksum="C4503BADB6DD2177" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PN67</accession>
    <name>A0AAN6PN67_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit delta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit delta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">C8A01DRAFT_44144</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854334">
        <property type="protein sequence ID" value="KAK4042928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PN67"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10233">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10233:SF14">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="60"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="76"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="117"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK4042928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="471" mass="50113" checksum="840C41DFB9D70111" modified="2024-10-02" version="1">MAAENNGGPSNGAPSHGAPTGSGAPAAQDGPKNAPPAPANATAAPANTEKLTAAQLKAKAKAEKAARRAQVKDARAAAAVAPPAQEKGAAADGKGGKGKGRQDGQPQNKGGHLQAHRPSVSGRRPSSPMVEKDVRSGIPDCFSHIPMAKRIPTSQAHKDVHPAVLAVGQQMATFALNDSISRLKATLLAFRKVIESYETPKGNSLSRHFVPHVLNPQIEYLTECRPMCFAMGNAIRLLKGKVNKFDIDTAEDEAKEGLLEWIDFLINERITLAEYAIAQNAAQSINEGDTILTYGHHRLVEKTFLEAKRDGKSFDVTVIDDPFERNGQELAKTLRQAGIPVLYSPNLGGLRPKVAAASNAFLGGEAIFANGSLHAPSGTADVAMAAMNAGVKVIVLCETINFDRDRVSVDSLTYNEIDPERNTADCFRLLFDNTHDKYITGVITEFESGGGNSPAQAILALLRKQEDPLID</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PN69</accession>
    <name>A0AAN6PN69_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_31750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854321">
        <property type="protein sequence ID" value="KAK4044148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PN69"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="145"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4044148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="161" mass="17483" checksum="AA08FB639571621A" modified="2024-10-02" version="1">MSGRKRKQEEEEELVSLPSGDEEEEEYVSDEEDEDELDDDEEDEDFDEEGGEGEEGEEENEENAVPAQAPPKKKLKTAPTAEAPHKNGTAANGHKEDEGPEGEEDEEFDEDEEAEGEEDEEDEDEDVEEDEVPAKGVGKVAAPTAGKAGSKAVAVGGDEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PND0</accession>
    <name>A0AAN6PND0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Adipose-regulatory protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_12361</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854320">
        <property type="protein sequence ID" value="KAK4044238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PND0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140042">
        <property type="term" value="P:lipid droplet formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23995">
        <property type="entry name" value="Seipin_BSCL2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009617">
        <property type="entry name" value="Seipin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21212">
        <property type="entry name" value="BERNARDINELLI-SEIP CONGENITAL LIPODYSTROPHY 2 HOMOLOG BSCL2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21212:SF0">
        <property type="entry name" value="SEIPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06775">
        <property type="entry name" value="Seipin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="214"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="52"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="247"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="321"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4044238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="411" mass="43892" checksum="EF714E214B85D79B" modified="2024-10-02" version="1" fragment="single">SVGPNPFGIASLEGIANRQPYDITVSLTLPRSPTNLDRGNFMIALHLLSPGRTTSGSSPQKPLPYLPPAKPAASDGTTPPSSWHALDTLLQPTRLDLPSFLASHTIVHTTTRPALIPYVDPLAALTTRVLLLVYHVLAPRAAATVHLTVPMAEDLAFVTQKQQQQRRRESLLPLLPESLLLEVQAGQGIQVYEARVTLVARLGGLRGFMYRWRVTAFVVFTVGFWVGEVGMLAAAVLVVGVSFGGGSERGGGGGGGGGGRRGVGGKGWDYDFEEEGSSSSEDGGEGRGRGKRGPRDVKDGERRVAIKAEASPSSASEGEEAERRAVKKEEVPEEEEEEDLAKVPPFETGQSTEADDEAETEGVERRKGKGKEVKREGGVESKDLGIGTSYSGQGSKEGARRRKVSFSRETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PNN6</accession>
    <name>A0AAN6PNN6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_13263</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854330">
        <property type="protein sequence ID" value="KAK4043198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PNN6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="510"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="315"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="475"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="576"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4043198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="703" mass="73339" checksum="42BE4581BBC4735F" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PNY1</accession>
    <name>A0AAN6PNY1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">rRNA methyltransferase 2, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_44349</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854338">
        <property type="protein sequence ID" value="KAK4042599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PNY1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008650">
        <property type="term" value="F:rRNA (uridine-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01547">
        <property type="entry name" value="RNA_methyltr_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050082">
        <property type="entry name" value="RNA_methyltr_RlmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015507">
        <property type="entry name" value="rRNA-MeTfrase_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920">
        <property type="entry name" value="RIBOSOMAL RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920:SF18">
        <property type="entry name" value="RRNA METHYLTRANSFERASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="9">
        <location>
            <begin position="738"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
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        <source>
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        </source>
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        </source>
    </evidence>
    <sequence length="1027" mass="112226" checksum="56C1599674A1D7F1" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PNY6</accession>
    <name>A0AAN6PNY6_9PEZI</name>
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        <submittedName>
            <fullName evidence="10">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_42704</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
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        <subcellularLocation>
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        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN-LIKE 3 HOMOLOG"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
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    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
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        </source>
    </evidence>
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        <source>
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        <source>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK4044523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="552" mass="60144" checksum="938F726F14C5EF7C" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PP36</accession>
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        <recommendedName>
            <fullName evidence="2">RNB domain-containing protein</fullName>
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    </protein>
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        <name evidence="3" type="ORF">C8A01DRAFT_12105</name>
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        <name type="scientific">Parachaetomium inaequale</name>
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        </lineage>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854318">
        <property type="protein sequence ID" value="KAK4044546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="NA-bd_OB-fold"/>
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    <dbReference type="InterPro" id="IPR057912">
        <property type="entry name" value="OB_CYT4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050180">
        <property type="entry name" value="RNR_Ribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056625">
        <property type="entry name" value="SH3_CYT4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056624">
        <property type="entry name" value="WH_CYT4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355:SF65">
        <property type="entry name" value="EXORIBONUCLEASE CYT-4, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G01550)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25522">
        <property type="entry name" value="OB_cyt-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23214">
        <property type="entry name" value="SH3_CYT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23216">
        <property type="entry name" value="WHD_CYT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNB" evidence="2">
        <location>
            <begin position="570"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4044546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1083" mass="119246" checksum="B7442B738C1696A3" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PPD3</accession>
    <name>A0AAN6PPD3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribonuclease H-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_11809</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854316">
        <property type="protein sequence ID" value="KAK4044763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PPD3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06141">
        <property type="entry name" value="WRN_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000100">
        <property type="entry name" value="3'-5' exonuclease/helicase (Wrn), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051132">
        <property type="entry name" value="3-5_Exonuclease_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13620">
        <property type="entry name" value="3-5 EXONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13620:SF104">
        <property type="entry name" value="EXONUCLEASE 3'-5' DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3'-5' exonuclease" evidence="4">
        <location>
            <begin position="174"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="423"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="433"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4044763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="442" mass="47692" checksum="B4577DF900AED2A5" modified="2024-10-02" version="1">MSTRKTAHQVWHVSRGIVFAGGTSVVYPRLPAVRHHSAPAAVASEGSSIPLPPVLSMADVPAEPPAGQGPETMLGHVVATSTTTRTTTTITSTAVVGEGPIGQGQGAVIGIVEKPKSKDTTPDAVPFTPLDYKMPDKAFQAARQAPEGTPESFWNYSLYRGPGKDGALVTKVKVHYCTSVHTTERVINEHFMNEKIVGLDLEWMANAQKSYGPRKNVSLIQLASTSRIGLFHIAAFPEKGALVAPALKKLLEDPAITKVGVWIKGDCTRLSEYLKIETRGQFELSHLYRLVKFSASGEYDLINKRLVALGTQVKECLGLPLFKGDDVRTSDWTKRLSLDQIIYSSSDAYAAVQLYAVLNHQRQKLDPVPDIPHHAELNIPIPVVKPVPEVTEQDADLAAADPDPASQTAPVAEARLDVKPSVEPAIPPLNILNPVQQAPTTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PPL2</accession>
    <name>A0AAN6PPL2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2 5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_31069</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2 5"/>
    <dbReference type="EMBL" id="MU854316">
        <property type="protein sequence ID" value="KAK4044883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PPL2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43811:SF19">
        <property type="entry name" value="39 KDA FK506-BINDING NUCLEAR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43811">
        <property type="entry name" value="FKBP-TYPE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4044883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="53" mass="5646" checksum="72596B25CEA8F15E" modified="2024-10-02" version="1">MTFRGLELEEKRKLTIAPSIAYGDRAVGGVIPANSTLVFETELVAIKGVTPGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PPQ3</accession>
    <name>A0AAN6PPQ3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Structural maintenance of chromosomes protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">C8A01DRAFT_44058</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMC family. SMC4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854333">
        <property type="protein sequence ID" value="KAK4042989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1620:FF:000003">
        <property type="entry name" value="Structural maintenance of chromosomes 4"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.60.10">
        <property type="entry name" value="Cyanovirin-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011058">
        <property type="entry name" value="Cyanovirin-N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036673">
        <property type="entry name" value="Cyanovirin-N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
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        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937:SF172">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES SMC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08881">
        <property type="entry name" value="CVNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51322">
        <property type="entry name" value="Cyanovirin-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="8 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="14">
        <location>
            <begin position="716"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1047"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1151"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="507"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="595"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="1223"/>
            <end position="1284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="86"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="118"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1047"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1154"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1201"/>
            <end position="1215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK4042989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1625" mass="180344" checksum="9FA5F34AA514E8CD" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PPZ9</accession>
    <name>A0AAN6PPZ9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_11877</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854316">
        <property type="protein sequence ID" value="KAK4044867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PPZ9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="166"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="217"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4044867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="309" mass="33412" checksum="771F0F13FBE9BB48" modified="2024-10-02" version="1">MTSSKSSAQHPLRDSWLSAQMLLQPSVEREDAEIEDLSLATIMDEDPLIYFLTPTPSTYAADEGMDFDMDFDAGIEDAKHPPQIIRSVSPSSLGGLSRPPPPARPLTPPRSPATPDLDYDLSATPDEHERYDYLENSWPPNRHAGSSSSPLSLPRRLKDKFKGHGSSSSSSSSSADSLVVPYSSSPRPSSSRGRATSRTGPKPVAAASGNTRRSRGTTTTTTTTTTTTTTTASSSSRLSPHAWREPSPDVWAIEEEPEEEEMLLRSSGMMGDGGFMGEVGRAVDIPAAKPKKKVRFVLPAVEDYRGTPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PQ08</accession>
    <name>A0AAN6PQ08_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heterokaryon incompatibility protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_31986</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854323">
        <property type="protein sequence ID" value="KAK4043888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PQ08"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF82">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26639">
        <property type="entry name" value="Het-6_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="44"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4043888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="622" mass="69954" checksum="E8D7F37ABFFA1991" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PQM6</accession>
    <name>A0AAN6PQM6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Pre-mRNA-splicing factor SYF1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Pre-mRNA-splicing factor syf1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">C8A01DRAFT_33072</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in pre-mRNA splicing and cell cycle progression.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the crooked-neck family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854335">
        <property type="protein sequence ID" value="KAK4042820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PQM6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000349">
        <property type="term" value="P:generation of catalytic spliceosome for first transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000666">
        <property type="entry name" value="DNA repair and transcription protein (Xab2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000023">
        <property type="entry name" value="Pre-mRNA-splicing factor SYF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000720">
        <property type="entry name" value="Pre-mRNA-splicing factor SYF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000038">
        <property type="entry name" value="Putative pre-mRNA-splicing factor SYF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055433">
        <property type="entry name" value="HAT_Syf1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056350">
        <property type="entry name" value="HAT_Syf1_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055430">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045075">
        <property type="entry name" value="Syf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246:SF5">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SYF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23231">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23233">
        <property type="entry name" value="HAT_Syf1_CNRKL1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23220">
        <property type="entry name" value="HAT_Syf1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1-like N-terminal HAT-repeats" evidence="15">
        <location>
            <begin position="19"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA-splicing factor SYF1 central HAT repeats" evidence="13">
        <location>
            <begin position="182"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1/CRNKL1-like C-terminal HAT-repeats" evidence="14">
        <location>
            <begin position="397"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="801"/>
            <end position="822"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00039472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00067212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF23220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF23231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF23233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK4042820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="822" mass="95657" checksum="34660D14E83EDD3E" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PR31</accession>
    <name>A0AAN6PR31_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_31466</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854319">
        <property type="protein sequence ID" value="KAK4044413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PR31"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4044413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="290" mass="32602" checksum="4DD58D68F8F9C932" modified="2024-10-02" version="1">MPQPAQARERATRSVECHCEPAPAAATDALLQRPQPRTPTQGPLLNKCTINFYNSNIAPGRRSRPRPPPPAPTVIEEIREVEEEARIPMFAPRRAPPSMRPDSRVYDRYGFDGYRRGRSPAQSFGNSPSRFNGITLLDRQNGGVTLRDDRGGEVFHYPGVSPPRGRSRAAARSRIPIPIAPVRGVQQFERPRYNSQAGIDARCHPDRPSVTMGVFRAEEERRLREHMRRQFARHYKPARARNRAAGDGVRARRVRDRWESDSSTEIGGLVQSTSNLAGPNSVQEARDSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PRX8</accession>
    <name>A0AAN6PRX8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_12467</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854321">
        <property type="protein sequence ID" value="KAK4044189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PRX8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050565">
        <property type="entry name" value="LYPA1-2/EST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655:SF63">
        <property type="entry name" value="PHOSPHOLIPASE_CARBOXYLESTERASE_THIOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="3">
        <location>
            <begin position="28"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="280"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="280"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4044189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="305" mass="32778" checksum="DF2D09FA2DBC6AD8" modified="2024-10-02" version="1">MATSTSTTDPTPQDLPIITIPPSNPALHTHTVIFLHGRGDNTKSFTRALHAWTSSQGLTLFDAFPTIHWVFPQAPLRPVASTANQFPQHICPQWFDVWTPRDFALREEVQLEGLREMVPAVRGMIAREAGKLGGRWDRVVLAGISMGAATGVHTLFNLDVPAEGGGRLAAFMGFCGRCPFAGRDLKGMREVLALPPAGEGTGTPVGGEDGVLRRTPVLLEHNVDDPLVLIENGRGLRDTLRGFGAQVEWREYAVGGHWFQAPEGIDDVIEFLNRVVLGREGGGGAGEGGQSQAVADSGAMEMDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PSZ5</accession>
    <name>A0AAN6PSZ5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Alpha-ketoglutarate-dependent dioxygenase alkB 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_12528</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the alkB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAK4044020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="AlkB-like"/>
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        <property type="entry name" value="AlkB-like_sf"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 6"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4 9" id="KW-0223">Dioxygenase</keyword>
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    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="8">
        <location>
            <begin position="111"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00007879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4044020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="252" mass="28269" checksum="47E8340B5609DED1" modified="2024-10-02" version="1">MDSPSSPIRLPASLEASKIHALPAAAYYIADFISEEEEQAILHKVETAPKARWRQLTHRRLQTWPSDLVKDTLLGARPLPAWLEDPVVARILSIPVSESEPNLFASSPHGRPNHVLINEYPPNTGIMPHKDGSAYYPVVCTVSLGSSLCLNLYKSKEDGALDPEPVWRILQEPRSLLVTTADLYSEYLHGIEPISTDVDISEQTIANWSLLRSPSPYQDGLNERQTRTSLTYRDVLKVSKLGNKLRPLFKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PTQ3</accession>
    <name>A0AAN6PTQ3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Mitochondrial protein from FMP27-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_31198</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854317">
        <property type="protein sequence ID" value="KAK4044701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="FMP27_SW_RBG"/>
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        <property type="entry name" value="FMP27_WPPW_RBG"/>
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        <property type="entry name" value="Hobbit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15678">
        <property type="entry name" value="ANTIGEN MLAA-22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15678:SF6">
        <property type="entry name" value="BRIDGE-LIKE LIPID TRANSFER PROTEIN FAMILY MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10344">
        <property type="entry name" value="Hobbit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01214">
        <property type="entry name" value="Fmp27_GFWDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01215">
        <property type="entry name" value="Fmp27_SW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01216">
        <property type="entry name" value="Fmp27_WPPW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="FMP27 SW motif-containing RBG unit" evidence="5">
        <location>
            <begin position="1152"/>
            <end position="1254"/>
        </location>
    </feature>
    <feature type="domain" description="FMP27/BLTP2/Hobbit GFWDK motif-containing RBG unit" evidence="4">
        <location>
            <begin position="1272"/>
            <end position="1432"/>
        </location>
    </feature>
    <feature type="domain" description="FMP27 WPPW motif-containing RBG unit" evidence="6">
        <location>
            <begin position="1677"/>
            <end position="2182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="98"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1082"/>
            <end position="1141"/>
        </location>
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            <end position="1944"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2010"/>
            <end position="2032"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2503"/>
            <end position="2533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2605"/>
            <end position="2659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2770"/>
            <end position="2980"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2996"/>
            <end position="3024"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1847"/>
            <end position="1874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="118"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="130"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1112"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1917"/>
            <end position="1932"/>
        </location>
    </feature>
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        <location>
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        </location>
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            <end position="2636"/>
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        </location>
    </feature>
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        </location>
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        </location>
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        <location>
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            <end position="2950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2959"/>
            <end position="2969"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4044701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="3024" mass="338079" checksum="EE607D6207C87830" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SLX6</accession>
    <name>A0AAN6SLX6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_41381</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854639">
        <property type="protein sequence ID" value="KAK4032172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SLX6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF25">
        <property type="entry name" value="ABC-TRANSPORTER-REGULATING TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="17"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="51"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4032172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="324" mass="34856" checksum="4DCE336CD9CA3957" modified="2024-10-02" version="1">MDQTPIAPSKPSRIAIACARCKTRKHRCDGGKPKCGNCAARGLECGYAAVRRTRGPGKNKKGPGAAATASLSRQPPTEPTTTSNSPPKAQTKADFLLSGVYEHRESVEGHIEEVAAGRREYAPLLPRHIASRLIQNSFDAIMADYPLLDLPRFATLADEQYAACSTDPAGNPSRWALVNAVFALALRFKIAPGAENDLSMFPRALYQNAAAVLPELILHGDPSLLSVQALLAMAMFAHAVSDSRSSAMLTANASRQVELLQRVHARQGPPLPVFDAIAREEEAQLGRAYGIASALEALAAQRYGVRPLLSRPEDNITVPTPTWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SME4</accession>
    <name>A0AAN6SME4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_40915</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854588">
        <property type="protein sequence ID" value="KAK4032638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SME4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4032638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="406" mass="46576" checksum="76EF8DF2286B7ACB" modified="2024-10-02" version="1">MAPSPIWRTLPADITEHILSILVSAHFHTDPAYTWTSLRHLSAHQKRVIEHRFARFWLPRLGITLYAGVRHKIEYALDQTAPTFDGIHVNGGDTAVFAVQRQVHNPLLSVSQDSKPGRLAARYLRRAWEQYDPAAHRNITVRLGEGFLSGGCRGGYILNDTDLPGLEVLADNKIRFCWKGAVDELLWEEMYMRRVGEAMFIEACNEWCTKNPHDAAAEGEEPRLPPRRIQLKIWRCRVQAARRVAAFKHRVARSNATARPIQLKFGATSQRLHKQEPDPEALEAVKKWECCSSCSRWQTPDIFEVLEVEESVVPRLGVFQTWLRQRFQDDGKEGQDSHRVGLDTIVGLYSDEFAWRAWLVNTSGQGHEDGLDDVQLYMYQQRHRRLDTGLDAVLLGTEKVRWEQAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SMG5</accession>
    <name>A0AAN6SMG5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Urease accessory protein UreD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_19270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854507">
        <property type="protein sequence ID" value="KAK4033836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SMG5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40644">
        <property type="entry name" value="UPF0653 PROTEIN C607.02C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40644:SF1">
        <property type="entry name" value="UPF0653 PROTEIN C607.02C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="102"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4033836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="327" mass="36536" checksum="FFB8C61ED036EA22" modified="2024-10-02" version="1">MPHKHTRRDKDEATFDLPPTQIAKPLPTTTISKKKAPAKKSDDAQKTSGQKRKRGAKDADDAPRAFKRLMAFASGKPQRTGLDNGDAPAKGKGKKKTKTKPTTKPTDPTPTASDPAPKDDLKIRPGERISEFNQRVDAALPLSGLVTKTVKNGRDPLGLKVKRTKKERKMHNMYAEWREMDRKVQERREEERELAEEKEMENEAMGVTWKLDLEAAQGKKKKKGKKGKRGKYIGEEGGPEKDPWAELKKKRGEAKVGLNEVANAPPELKLPKKNLLVRGAAVAVEDIPKAAGSLRQREELQSIRQEVVESYRKMMSERRPAVSTGDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SN62</accession>
    <name>A0AAN6SN62_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_40060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854527">
        <property type="protein sequence ID" value="KAK4033492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SN62"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025213">
        <property type="entry name" value="Sim4_Fta2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13095">
        <property type="entry name" value="FTA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4033492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="247" mass="28541" checksum="2DBCFFC106FD728D" modified="2024-10-02" version="1">MDPIVSLSDMPKPLPQLPGPKLAPFTPTAHAEIEFVEELGSPAVDMDSFVWKVRINGSTSFYALKMFRFYSSTYLRQTTGRYLNRPFASPRRYIVYFDPFNCECRAYGRLQAESRQDLAIQAHGYLLLTPEQEASVAIRISAIGPDPRDPRDALDVTDDPWDRMEEHYGQPVHAIVKDFATDEYEFSPNQVCDMWRDLEDLHKLGILVRDIEIVNYLGGKLIDFSRSWTTPHPSLEHIHPRDLRRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SND0</accession>
    <name>A0AAN6SND0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_18487</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854466">
        <property type="protein sequence ID" value="KAK4034766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SND0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF151">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="217"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="71"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="355"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="307"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="392"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4034766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="401" mass="43341" checksum="FAAF3606693E6291" modified="2024-10-02" version="1">MADSVLPGIQGYDPHNIQPWTVAVMASVTVLAAAAVALRLLSTSCSGAGELMFSLPVNTADSTRNQLWNFVVVGFIFAMHNAGMGIHADKVPVANIVLMAKYLLVAEILYIYNLVWTKISILLMYYRIFHFPYFKKMAYGIGGFVVAWVVTCTFMFVFICVPVAKVWYPDLPGHCIDQVGTWIANAASTILTDVAILALPIPQVWKLQLRKPEKIGVTVAFCLGFFVVFASAYRFTVLFSYTNDDPSYSLAPTVGWTAIEMSAGIISACLPTLGPVMAFFAGKMGIKRTILTSRGGGGATTGASSGNFKSTATPSLSDRAEVELQKTTKKDNAGTFYRLPDDQLSGDTARAVDAELRPEHGYGYSVTSRPGNVKGDAESSSGDEAPLHGIRVHRDFKQSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SNG6</accession>
    <name>A0AAN6SNG6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fungal N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_19454</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854519">
        <property type="protein sequence ID" value="KAK4033615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SNG6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4033615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1061" mass="117708" checksum="B92B134498E01878" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SNU5</accession>
    <name>A0AAN6SNU5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chorismate synthase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_18010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854449">
        <property type="protein sequence ID" value="KAK4035276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SNU5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39470:SF1">
        <property type="entry name" value="CHORISMATE SYNTHASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39470">
        <property type="entry name" value="CHROMOSOME 10, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4035276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="358" mass="39249" checksum="97567FDF1DEEA187" modified="2024-10-02" version="1">MAIPWGTIKSLLIFFGPLLLPKAIGYYRRARAAPQIHGLKVRPLPARTARAVAVLLAVAAVFLLRTLPILSPENIFKVTQSRLQIPADVLFTRLAALRPGNTLTPTDLLLRAKFASLESRLLYLQHGPAVLATCPFCTSDEPRAYLYYALPDLLAPHLFNLVLIALATSSLFTHSRAERGWRTPATLAAVAAAFVDVYWVSTYNHTANARALRLHEMDAFFWTARAVRYAAVAVVDVLLALGLYLTGTQRAFVAAPSAAERVEGVVRALGGTKGKINAAGVVKNTVLRDEELRGRSTAYWAHEVRLMREMMEEREVVEGVNDALVNRIDIGGIERDAEAYARAVLMPQGGEVKEEVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SPB8</accession>
    <name>A0AAN6SPB8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Multicopper like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_18599</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854471">
        <property type="protein sequence ID" value="KAK4034648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SPB8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13857">
        <property type="entry name" value="CuRO_1_Diphenol_Ox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13886">
        <property type="entry name" value="CuRO_2_MCO_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13910">
        <property type="entry name" value="CuRO_3_MCO_like_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000045">
        <property type="entry name" value="Laccase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
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        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF414">
        <property type="entry name" value="ADR239WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
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        <location>
            <begin position="31"/>
            <end position="58"/>
        </location>
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        <location>
            <begin position="124"/>
            <end position="238"/>
        </location>
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        <location>
            <begin position="250"/>
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        </location>
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        <location>
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            <end position="641"/>
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            <begin position="65"/>
            <end position="86"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK4034648.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="662" mass="71995" checksum="FFF0CE3A11FF52A3" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SQE7</accession>
    <name>A0AAN6SQE7_9PEZI</name>
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        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_37631</name>
    </gene>
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        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854429">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SQE7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
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    </dbReference>
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        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
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        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
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    </dbReference>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
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    </dbReference>
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        <location>
            <begin position="37"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
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        <location>
            <begin position="69"/>
            <end position="100"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK4038450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="364" mass="38931" checksum="326A3DDA0A6DB56C" modified="2024-10-02" version="1">MDPAAPNGAPHDQARRGGGCRCRPPPLPLPAPRKRKACNFCFNRKIGCDSNPEGCSECRSRGLTCTYSWAKPQPKRGSRRNAQNQHAPPPNAFPGPNDALAFGSPLVPAPMSNQQWDPTFAAFQPDEGFFSAATTVPSFDTPPAAKLLPMEWLTIQDDVPENAFTDPAAWYGQVNSPGAAPPSPCGCLDACLSAGHALNMNLAVPGPSGPSLPPALRVIMATAVDKLLDCIECTTKAFLQQPPVAAMLVSTLAKIRFLYRYVASTPPTPPVDGPLPSGWELPSTDLDFVAAVYRLESICQKCDFIFKGHVQAGSEADFLVLDFSDKLLDLWLSLSVGGRHGHYEAVIGTSGQRIHGGGAQRLVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SR66</accession>
    <name>A0AAN6SR66_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_36903</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854409">
        <property type="protein sequence ID" value="KAK4039141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SR66"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052779">
        <property type="entry name" value="WDR62"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45589">
        <property type="entry name" value="WD REPEAT DOMAIN 62, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45589:SF1">
        <property type="entry name" value="WD REPEAT DOMAIN 62, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101908">
        <property type="entry name" value="Putative isomerase YbhE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="766"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1001"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1075"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="821"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="839"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="860"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="915"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1010"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1075"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1092"/>
            <end position="1102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4039141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1117" mass="119276" checksum="84E2A30D5AF505C1" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SRX6</accession>
    <name>A0AAN6SRX6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">fumarate reductase (NADH)</fullName>
            <ecNumber evidence="7">1.3.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">NADH-dependent fumarate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_16030</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>succinate + NAD(+) = fumarate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18281"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.3.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.6" evidence="7"/>
    <dbReference type="EMBL" id="MU854385">
        <property type="protein sequence ID" value="KAK4040070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SRX6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016156">
        <property type="term" value="F:fumarate reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.700.10:FF:000007">
        <property type="entry name" value="NADH-dependent fumarate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050315">
        <property type="entry name" value="FAD-oxidoreductase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010960">
        <property type="entry name" value="Flavocytochrome_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01813">
        <property type="entry name" value="flavo_cyto_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43400">
        <property type="entry name" value="FUMARATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43400:SF1">
        <property type="entry name" value="FUMARATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="9">
        <location>
            <begin position="531"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00050832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00067004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00077246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4040070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="615" mass="66268" checksum="75A0B720C15BD0DA" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SS68</accession>
    <name>A0AAN6SS68_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_46094</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854373">
        <property type="protein sequence ID" value="KAK4040627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SS68"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990275">
        <property type="term" value="F:preribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19481">
        <property type="entry name" value="RecA-like_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002838">
        <property type="entry name" value="Uncharacterized ATPase YjoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF132">
        <property type="entry name" value="ATP-DEPENDENT ZN PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase AAA-type core" evidence="1">
        <location>
            <begin position="231"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4040627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="478" mass="53872" checksum="929D274C41DE698B" modified="2024-10-02" version="1">MDSNQPLPADKTTSNEITRQFFRHSSAKRVNTDATIARALKTEYPDLQLVIVPSWGIDLLGYASAGHASFTSIDQAGDELPSSLIWKVYVAPGRRIDGNPGRLAQDVLFAKFLYKWRDTEFILYVVDGRDGTSSYPSVRNNYILTTDTAKADALVLAAGQWDNELHGQVWVWDNGMWRKSAELFQSISKASWDAVILEEGMKKAIIADHQSFFDSRDTYGRLKVPWKRGLIYHGPPGNGKTISIKAMMHTLYDRKDSVPALYVRNFNSFAGPEYGISQIFLKARQFAPCYLIFEDLDSLVTDSVRSYFLNEIDGLQSNDGIFIVGSTNHLERLDPGISKRPSRFDRKYYFPDPDLDQRVAYCRFWQRKLADNKDVEFPDKLCKAIAGITEGFSFAYIQEAFVASLIVIARDSEGSTGWESMGSDGIEDGWVGVGASEDDGDLEDLVLWVEIQKQVAILREGMEEKRAWVARGSSSRCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SSI5</accession>
    <name>A0AAN6SSI5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nucleophile aminohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_46139</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854375">
        <property type="protein sequence ID" value="KAK4040506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SSI5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005839">
        <property type="term" value="C:proteasome core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03757">
        <property type="entry name" value="proteasome_beta_type_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000027">
        <property type="entry name" value="Proteasome subunit beta type-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF2">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4040506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="265" mass="29070" checksum="EBACC95319D70331" modified="2024-10-02" version="1">MAAMFSQNPLMNGPNYSVNDAPRVNAPEGAREHRFDPYTDNGGSTLAIAGAEFAVMAGDTRLTSGYSINSRHHPKLFKIGGTTADQKDATIVLSVVGFAADGEALKEKLDAVCKMYRHRHGKPMSVKACAQRLSTILYQKRFFPYYAHAILGGLDEEGKGAVYSYDPVGSYEREQCRAGGAAASLIMPFLDNQVNFKNQHIPNSGEGHALQERERRPLTRNEVEVLVKDAFDGAVERHIEVGDGLQMMVITKDGIEEVLLPLKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SSJ0</accession>
    <name>A0AAN6SSJ0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_35468</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854375">
        <property type="protein sequence ID" value="KAK4040521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SSJ0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042990998" description="Extracellular membrane protein CFEM domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="122"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4040521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="242" mass="24925" checksum="79EDB18E0FA37611" modified="2024-10-02" version="1">MVLASYVRLALLGAALFVSPAQATFQFPSCVESCVVSSGCKTNNARCMCTAARELLLDSVISCLFFSCKDDLRNFEDAFLDPIEQGCEDSNRDIPRSKLRAAESLATSYIGKLPSPTTFKSTTVEVTHTPKPTTKPSPATTAEAPSSSSTTTTTTTTTTTEEGEPTPSSSSAAERGAEESTSTAATQSAATPSQSPTSDDSGSSGGFAANPFGSPSGSAGSAIQPLLVLLSLPLAVSMLALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SSP3</accession>
    <name>A0AAN6SSP3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Concanavalin A-like lectin/glucanase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_34308</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854353">
        <property type="protein sequence ID" value="KAK4041704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SSP3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070007">
        <property type="term" value="F:glutamic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13426">
        <property type="entry name" value="Peptidase_G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.700">
        <property type="entry name" value="Peptidase G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000250">
        <property type="entry name" value="Peptidase_G1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038656">
        <property type="entry name" value="Peptidase_G1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37536:SF1">
        <property type="entry name" value="ASPERGILLOPEPSIN, PUTAITVE (AFU_ORTHOLOGUE AFUA_7G01200)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37536">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02970)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01828">
        <property type="entry name" value="Peptidase_A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042950215" evidence="3">
        <location>
            <begin position="20"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600250-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4041704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="309" mass="31445" checksum="2E61DAB27926F0E0" modified="2024-10-02" version="1">MKPTTLLTLLATATAGTSAAATRPLPLAPTRPRDAAAQHPHRLLHTLTPAAPSTANFRVLAAATESTKGGAVLTLPNSKLSTIHATLRVPEAKIPTAGPTANNPVGVYAASFWVGADAVVTGACAGGGALRAGVDIFYDGTLGGVQRPFVWYQGPGQGSETGFAGFEVAAGDLVRFKLEVGSEEGGEVVVVAENFGGNVTCVKDNGAVPVSSVRQVLPASVGGKTLCRGEAAWVVEDFPLEGLPDFPVALANFTSVAFGAGVTLEDGSERDLAGAEVLDVRLEAQGGRLTSCEVVDGKKVKCARVVGDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SSQ9</accession>
    <name>A0AAN6SSQ9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribokinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_15039</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854362">
        <property type="protein sequence ID" value="KAK4041197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SSQ9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01943">
        <property type="entry name" value="MAK32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034094">
        <property type="entry name" value="Mak32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47098">
        <property type="entry name" value="PROTEIN MAK32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47098:SF2">
        <property type="entry name" value="PROTEIN MAK32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="2">
        <location>
            <begin position="387"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4041197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="463" mass="49654" checksum="B4A366EC067AFE21" modified="2024-10-02" version="1">MVLHRDLDPEMDPNMGPDRGLTDGAPAGAEPDHGAGDIPDTQEIDFVTLGMFIIDEIEFLPPKPPAHDILGGAGSYSALGARLFSPPPSSKTIGWIVDQGSDFPPSITSQIATWQTSALLRHDPSRLTTRAWNGYADASECRSFRYTTPKKRLTTTDLTPPLLQAKAIHLICSPLRCQDLVASILARRKEAYFSSPPPHDPHGECYMRPIIIWEPVPDLCVPTELLNCTNTLPLVDVCSPNHAELAGFMGSDGLDPDTGAVSAAAVERSCEQLLASMPLQSYTLVVRAGEKGCFVARNGGRKKKVSTGGSGAGGGLGGQGGAGRKTVKKREYIRGGLRPDTDMEALFAGLMQDAEGCVAREEIEIDPGVEKWVPAYYGEGYGKKDVAEKVVDPTGGGNTFLGGLAVALARGKSIEEACAWGHVAASFAIEQVGFPVLSVDEEGRETWNGVRVDDRLREFQERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SU18</accession>
    <name>A0AAN6SU18_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_44448</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854339">
        <property type="protein sequence ID" value="KAK4042562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SU18"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042986364" description="Peptidase A1 domain-containing protein" evidence="7">
        <location>
            <begin position="19"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="510"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="8">
        <location>
            <begin position="38"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="265"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="268"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4042562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="570" mass="58624" checksum="7F03D606272D9ABA" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SUB6</accession>
    <name>A0AAN6SUB6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_44202</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854335">
        <property type="protein sequence ID" value="KAK4042847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SUB6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="242"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="367"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4042847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="385" mass="41679" checksum="BE74D8CF8E98DB29" modified="2024-10-02" version="1">MPVPVAAKVGIVAASVAVAAAIAIYEIPEVRRAAEDLRRRIAVALYALGENVDPNREPREPRFNRPEDAEGFYQTHDVDADEETRRRQREELMYWNLRREEQQRDHEQVQQRPRGSTFDDFLSPDRTSDNGTFVYNTGANAWDAEPSNVLRRRANAEGVRGLDAAAMLANPFSDEHGIELEDRAELPPPAPARRAGTMSSDIYNATPMVLSPVAAPAPAASEVLFDFESHNNNHPSEPPNQRPATPTTTAASTTTRSSATLDRELAEDEYMTAGQDDDAYASIQAWAHHTSSSNNTAGFYSPLPHTPQAPLSEPEIISEAGGQHTPTDSASVAGSGVDVAHDDAVSHDDDFDAMSESDDGAGIHTPGSWSKVGSVVSEGESLARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SUZ6</accession>
    <name>A0AAN6SUZ6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">S1 motif domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_32817</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854332">
        <property type="protein sequence ID" value="KAK4043028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SUZ6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05791">
        <property type="entry name" value="S1_CSL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000198">
        <property type="entry name" value="Exosome complex component CSL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039771">
        <property type="entry name" value="Csl4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019495">
        <property type="entry name" value="EXOSC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025721">
        <property type="entry name" value="Exosome_cplx_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12686">
        <property type="entry name" value="3'-5' EXORIBONUCLEASE CSL4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12686:SF8">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT CSL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14382">
        <property type="entry name" value="ECR1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10447">
        <property type="entry name" value="EXOSC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110324">
        <property type="entry name" value="Ribosomal L27 protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0271">Exosome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="4">
        <location>
            <begin position="103"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4043028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="227" mass="24601" checksum="224B49CD3D5F42FC" modified="2024-10-02" version="1">MTTTPPTLALPGQLLGPAARYQPGPGTHLHDANLYASLLGQVHITQPARAPGPAKRLTKITPAPAPAELPTISVAVAASNTLPPGAERDVNKNKNKRREVLPEVGNVVLCRVIRITPRQAVVAILVCGDTVLEAEWQGLIRVQDVRATEKDRVRIYESFRPGDVVRAEVISLGDQANYYLSTTRNELGVVLAVSEAGNTMQPVSWKEFRDPETGAMELRKVAQPQPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SVM0</accession>
    <name>A0AAN6SVM0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">SNF2 family N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">C8A01DRAFT_30929</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854316">
        <property type="protein sequence ID" value="KAK4044749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18070">
        <property type="entry name" value="DEXQc_SHPRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000059">
        <property type="entry name" value="SNF2 family helicase/ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001870">
        <property type="entry name" value="SNF2 family helicase/ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052583">
        <property type="entry name" value="ATP-helicase/E3_Ub-Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059033">
        <property type="entry name" value="C144_05_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45865:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SHPRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45865">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SHPRH FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26021">
        <property type="entry name" value="Ferritin_C144_05"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="334"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="1138"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="1250"/>
            <end position="1402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="739"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1196"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1449"/>
            <end position="1483"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="1091"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1450"/>
            <end position="1460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK4044749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1483" mass="167079" checksum="328F40421D434AA4" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SVU2</accession>
    <name>A0AAN6SVU2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_42862</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854319">
        <property type="protein sequence ID" value="KAK4044437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SVU2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4044437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="424" mass="48891" checksum="B077F9A84AAB0CAC" modified="2024-10-02" version="1">MAPYMSLEHAHRSYGPVDRDALSGRLSKSERGLLRVGLVKSEQWRRLPTEGLYQIVISEVLDNGLTYALERSGGRAFAVTSVLDLGLRMMESLRGRNALENLARKAICVWRERPVPDPVIEPWNVDVPAAVDEFLRCVRYRFPIVKLDDRNGFCHEEENQTMPYSWVDEYSTLEQFDFNPKAAAVLHLNWQYILTQSPQLVEKLYWTRLKADIARRQSREDEHLAETVRFHRLQFHLAAMVTHHLCHLFVNFLRASEDLARAVTDADFMRLVRRYDPGAEFEIEFFGGRPKLFIDQRGPREDSYPGQSYVIKRGKGGGRVAAVVAQYKIESYLKGDFAVPLLTEVEGDVFPMERYQDVMRRYGGSRHESCQWREGQTGTRRVAEVGSFDQQAFSVPWDIQGAEYQMLKKACFDPAIRVVDPMGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SW44</accession>
    <name>A0AAN6SW44_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Mitochondrial carrier domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">C8A01DRAFT_12326</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854320">
        <property type="protein sequence ID" value="KAK4044258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SW44"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000009">
        <property type="entry name" value="Mitochondrial 2-oxoglutarate/malate carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050391">
        <property type="entry name" value="Mito_Metabolite_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45618">
        <property type="entry name" value="MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="43"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="144"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="243"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK4044258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="320" mass="33777" checksum="9D01ADD625B6D33B" modified="2024-10-02" version="1">MSNTVKQAAEAARSRGNEVMGTAKSVKNDSVAVANDFLHTPFMRAALPFINGGLSGMVATTVIQPVDMIKVRIQLAGEGSAAGPKPTPLSVTREILASGKALDLYTGLSAGLLRQAVYTTARLGFFDTFMDRLTARAKAKGQAIGFAERATAGLTAGGLAAMIGNPADLALIRMQSDGLKPAAERKNYKSVIDALASIAKAEGVGALWAGAAPTVVRAMALNFGQLAFFSEAKAQLKTRTDWSANGVTLSASAIAGFFASFFSLPFDFVKTRLQKQSRGPDGKLPYSGMADCFTKVAKQEGVMRFYRGFGTYYVRIAPHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SWB3</accession>
    <name>A0AAN6SWB3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_31141</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854317">
        <property type="protein sequence ID" value="KAK4044645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SWB3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4044645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="272" mass="30559" checksum="8A59EB5BC5C94156" modified="2024-10-02" version="1">MMLRNNTLPPFIHARKMSSSGAENDDDDMEPLNNCISLLHMIRSRVPGSRKLFWRNVRMECERFHQESLEWSKWRLLAAMQALSIYLIIKVDEGPTEYDNGLDSLIVAVVVTLATQMGGRVGDATLDNGGLDTRWDNWIFEESKRRLCVIYQVVDMLVYFQPAGMCHVRQQAELVIAPLPSKKQLWQAGDGFAWQAESDKEEAEARVAFALAANGELARLDLTGLLCITDWTSLHRGRDAGAPAWRTADWDEWCAGMDELGGLVMLAASLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SWK4</accession>
    <name>A0AAN6SWK4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_31236</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854317">
        <property type="protein sequence ID" value="KAK4044738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SWK4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008506">
        <property type="term" value="F:sucrose:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000593">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19432:SF35">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 45 MEMBER 3 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19432">
        <property type="entry name" value="SUGAR TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13347">
        <property type="entry name" value="MFS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="337"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="392"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="458"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="482"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="569"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="601"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="519"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="630"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="47"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4044738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="679" mass="74011" checksum="566D26136F8932FA" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P3V6</accession>
    <name>A0AAN6P3V6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_42260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854920">
        <property type="protein sequence ID" value="KAK4031264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P3V6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042910529" evidence="1">
        <location>
            <begin position="19"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4031264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="146" mass="15883" checksum="D821B1822D8AA081" modified="2024-10-02" version="1">MHVAAFTSAALLTLGVSAGTIDKRNGEGIHLANCYQQGKAFSQILYYADDSTSANGAQPYYADECSVTAPGAGFKTWEGSQISCTFPSGTSFTSKLPSGVQWYGTGQYAGPGWNNYRNFNCYKDDGHQLFDFGYTKCYSIYYCLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P5D4</accession>
    <name>A0AAN6P5D4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pleckstrin homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_20942</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854678">
        <property type="protein sequence ID" value="KAK4031915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P5D4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041681">
        <property type="entry name" value="PH_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37283">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN YHR131C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37283:SF1">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN YHR131C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15410">
        <property type="entry name" value="PH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pleckstrin homology" evidence="2">
        <location>
            <begin position="90"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4031915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="409" mass="46393" checksum="DB8869744CEA44C7" modified="2024-10-02" version="1">MARRPSDAFSQHSAGSDAPSGRPRRMSMEEDMFYRQLMTSRPAQPPSYDSAMKAVAAAQRRALAAAAGQGSGRHFPEDVLPQYSCGIHMEGVFMRKMEIEETTKRAEYRDWRMVYVELRGTALNIYSVKKERGWWSSSSKHDGPDISPDNPPWVKKSTLEKSYTLLHADAGIAADYRKRRYVIRMRVETDQFLLSCVELGTFVTWLDGIFAAINVSPPIDERDFPRDFSVPRIQRIRWLRGQRPQPEDSIGFHRLTEQRRRDGSDEDEDGDGEGEGEAEGEAEGEGGEPPDPGYGQDDDGSPGYGPRTDHPIVGRLSTTSYPNESIDPVTGKWKPQHGWSTTHDQLYARLCYSVLLFKSPRKSNYVIARGKRWYVDWGTGRMVRVLPPAYGEVDVMGPWQIIMPENRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P5M9</accession>
    <name>A0AAN6P5M9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Iron-sulfur cluster assembly factor IBA57 homolog, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_50939</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the GcvT family. CAF17/IBA57 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854633">
        <property type="protein sequence ID" value="KAK4032224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P5M9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="entry name" value="Probable tRNA modification gtpase trme, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057460">
        <property type="entry name" value="CAF17_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017703">
        <property type="entry name" value="YgfZ/GCV_T_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045179">
        <property type="entry name" value="YgfZ/GcvT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03317">
        <property type="entry name" value="ygfZ_signature"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22602">
        <property type="entry name" value="TRANSFERASE CAF17, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22602:SF0">
        <property type="entry name" value="TRANSFERASE CAF17, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25455">
        <property type="entry name" value="Beta-barrel_CAF17_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103025">
        <property type="entry name" value="Folate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="CAF17 C-terminal" evidence="6">
        <location>
            <begin position="338"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00093447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00093637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4032224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="424" mass="45616" checksum="9687AE1FD497987F" modified="2024-10-02" version="1">MQPARRVLASTGAASAVRSPGASTCRACLTRLPAPQRRAFSRSAPRHAAPPAPSPAGLAELSSRKLISVSGPDAAKYLQGVITANLFPGYAGPSPTSEHLRADAGFYAAFLTAQGRILHDVFVYRDARDTAHPPGHSWLVEVDAAEADRLQKHIRRYKLRAKFDVRLLDEGEGAVWQAWDDASPSLPPSLPSSISNTTVITTPDTRAPNLGHRLVTFSPTPSPPVSSPTLPLVPESSYHLRRYTHGIPEGQSELLFNQALPHESNADAMRAIDFRKGCYVGQELTIRTEHRGVVRKRILPCVLYPDGQPLPEDLVEAYRPEIEPGVTAEEIPREASIGRAPGGKKGRSAGKWLTGVGNVGLALCRLEIMTDVVLPGEASSGAGGFGEGDEFVVGLGEGEEGKKVRIKAFVPEWLRRGLVRGEGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P6A9</accession>
    <name>A0AAN6P6A9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7702 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_50648</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854594">
        <property type="protein sequence ID" value="KAK4032569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P6A9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056119">
        <property type="entry name" value="DUF7702"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42109:SF2">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42109">
        <property type="entry name" value="UNPLACED GENOMIC SCAFFOLD UM_SCAF_CONTIG_1.265, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24800">
        <property type="entry name" value="DUF7702"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="178"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7702" evidence="3">
        <location>
            <begin position="4"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="272"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4032569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="301" mass="32258" checksum="FAED75B597CD6166" modified="2024-10-02" version="1">MALNANSIVAIVELVAYVPAIIVSFMVCLRHGFHRSSGWLYTLALCLIRIIGAACQLATIPNPDDVPLITASVILENIGVTPLLLATLGMLSRLVDWTNRQNPSPTITIYHFRLVQLLILLNTILSIVGGTDNNATPTSPATESQVAAVFYVVTYAALLLILLVSARSRSLVPADERLIVPAVALALVPFIAVRVLYSLLVVFVHSGAFARIGGPAAARLCMATVEEFVVVAVYLFLGYRLARLDESERGEILSRPRYQQPSRSGPSSYDPEQGQGVSGVGEEYGLAQGHEGTGGGYPSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P6P8</accession>
    <name>A0AAN6P6P8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_21365</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854824">
        <property type="protein sequence ID" value="KAK4031403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P6P8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF13">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043015690" description="FAD-binding PCMH-type domain-containing protein" evidence="5">
        <location>
            <begin position="20"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="62"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4031403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="501" mass="54031" checksum="AA40DFFEF4D92EE2" modified="2024-10-02" version="1">MLPLTSICLTAILAARVTATASLSTMAACHEISAAVPARVWSNHLSKNYYSEVNSYWSTALRDAKPACLVLPQSAKEVAAAVKILNKYPDVQFAVKSGGHTPNERHSSIKDGVLISTRDLSGVTYDGKTQIASVKPGGEWNDVIGPLGEQGVAIAGGRLGLVGVGGYLLQGGISFLSAQYGLAADSIVGWEMVTADGTIRTIDASKEPELAVALRGSGSQFGIATEFKIKAYPIGQVWGGMRIYGGGKADDIYAALHNFVPGNADDEKAAIILSDVTAIGGAKIFLIFYFYAEPEPPTTGPLAQFLNIDSIIDITSTQSYAKLLKSNGEGAALLQSRVSFRTFTLPYVKDAPHMYGEISDKFTSLLADILKNPLRLTSQCSIDFQPFPSVIGRHSQERGGNAMGISGSDADRILLEIQCSWSSHNDDEIFRDASKKLTEWLEVKVPEWTKGREYYLPYLMNDAAGDQNVTGTYRGYSKFKALQAEMDPEGFFKKRGGGFVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P6V4</accession>
    <name>A0AAN6P6V4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_40787</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854577">
        <property type="protein sequence ID" value="KAK4032769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P6V4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="274"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4032769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="368" mass="39931" checksum="E28E37AF2A845C82" modified="2024-10-02" version="1">MRQNFTNIEPMTGGPIVKAVPDFFDGARAGDIYNKIRNADEEGNLNKLIIPTKHASAPVAPNFFLETKAPRGGADVTLRQALHDGAIGTRAMHALQNYGAGEPAFDGNAYTYSSTYHAGTGTLQLYAHHPTPPTAPGGRPEYHMTQLGSYAVTHSRERFVEGASAFRNARDMAQRRRDSFIQAANAKARQSDAEAPAEVDTTVAVAEQYEEATDEFVDCEDYPGSQAVSTDDYAAPGDVEEAPALPQYLYAEDEEPSQESASLGAEPAMSFATSFASSFSQSQTSSKRTRSPRSPPSNSQTRKKNSSARRTRQSASRQAAGSSTQASTCTGSALPPPALSEEYWTWSETYQKWYHVNEDGSCIWDDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P726</accession>
    <name>A0AAN6P726_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_20050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854562">
        <property type="protein sequence ID" value="KAK4032943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P726"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4032943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="58" mass="6454" checksum="2CE30A6C278A4C9A" modified="2024-10-02" version="1" fragment="single">EKPCDARKGLNILVDGVTDGACEAARRRPRSSFDHFFHDFCVMTGPNESTKILAPKTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P7P7</accession>
    <name>A0AAN6P7P7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_19774</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854542">
        <property type="protein sequence ID" value="KAK4033249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P7P7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042831364" evidence="2">
        <location>
            <begin position="22"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4033249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="120" mass="12642" checksum="CD15FF21E4F18410" modified="2024-10-02" version="1">MHCAQELFSLFILAIAAEVSSVGGTTSPLPPQGGKYRVWDNTLLTSLAEQAVRTKLAANIDEALTLVVPAFAHYNLLPKTDPVEQPACSEGEHTDAGVDERDGSDSDDGSDGGAWINGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P7R4</accession>
    <name>A0AAN6P7R4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_20601</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854624">
        <property type="protein sequence ID" value="KAK4032315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P7R4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="310"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="334"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4032315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="376" mass="41654" checksum="AF4F6ED02E2F1755" modified="2024-10-02" version="1" fragment="single">MAPINGDSKWNGAETLEKLCSGLAPLLSLFGEQVTRQFLSVSLGWSDHLMLASGPIGIIPVVASAIRIAGPEWLKALIGKGRDEPPLVEKELLSSTSKEVCEAWTGTNFSRTKGLLPSGSITALMLTADGKILDWQRRLPSTTVKDQKTSPRNDRELQKLREMANAAPNFTLNHRNPNRLGRFENWFYAVTSVALQITAFIISCLIAYQWQLFGSDRKRQDAGFGSYAACSTLLFIGLLGCGYVVDAVTTERTWKYRAKDQDPTKCPLALVWLQRECTVYDQYFAAYAVFNPPPNNLDVRTSTWNREAKDYRAVVTGSAATTVVGFILQLYGRWAMIWIISLVQLAQTLLATGLRSLACRKLAPNPPTIKLTSSQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P7S1</accession>
    <name>A0AAN6P7S1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CBM1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_50048</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854536">
        <property type="protein sequence ID" value="KAK4033334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P7S1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018535">
        <property type="entry name" value="DUF1996"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662:SF13">
        <property type="entry name" value="DUF1996 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09362">
        <property type="entry name" value="DUF1996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042823744" description="CBM1 domain-containing protein" evidence="5">
        <location>
            <begin position="24"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="6">
        <location>
            <begin position="368"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="332"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="343"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4033334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="405" mass="43644" checksum="195E75B4A7CDDC54" modified="2024-10-02" version="1">MKVQQRSFLAAALALAGAPSVDAVLRFSCSELVTERLDPLVFPGAAQSPHLHQIVGGNMFNITMDPARNNIADEATCTTCTFSEDFSNYWTATLFFRARNGSYIRVPQRPNIDFDGARGGGMTVYYTPSYQKTKVTAFQPGFRMIVGSPMYRTAAEAAKFRQLTFTCLETMYTRTGETTSMPTAPCKEGIMANVRFPTCWDGTNLDTPNHSDHVAYPSSGTFESGGACPASHPVKIPQLFYEVIWDTRQFNDKNLWPEDGSQPFVWSYGDFTGYGTHGDYVFGWKGDALQRAMDDNCDVACPTLKSQSIATGNQCKQEKKVAEQIDGWLKSLPGDVEVTGPQPGTGSGGNPGNGGGNNGGNNGGNTGGGSCQVAKCAVVGQWSGCTVCASGSTCRAQNDYYSQCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PB17</accession>
    <name>A0AAN6PB17_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fumarylacetoacetate hydrolase domain-containing protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_40844</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854582">
        <property type="protein sequence ID" value="KAK4032702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PB17"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018773">
        <property type="term" value="F:acetylpyruvate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050163">
        <property type="term" value="F:oxaloacetate tautomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.850.10:FF:000002">
        <property type="entry name" value="2-hydroxyhepta-2,4-diene-1,7-dioate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820">
        <property type="entry name" value="ACYLPYRUVASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820:SF7">
        <property type="entry name" value="ACYLPYRUVASE FAHD1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="3">
        <location>
            <begin position="67"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4032702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="277" mass="29659" checksum="09EA5107A646C09C" modified="2024-10-02" version="1">MSFQRLVRFVNAQGTTSFGDLKSEPTGDLAGAEVEVLEGDIEKGFRGTGRTDKIEKLLCPLPSVPLVICIGLNYQKHATEANLRIPPYPVVFTKPADALAGPLDAVSIHPDAQGMLDYEGELTVVMGRDAKNVNEAEALQYVLGYTVGNDVSARNFQLPDTSGGQFCYAKSFDGFAPIGPCIAAPGVVGDPQKLRLVTRVNGEVRQETETSDMIFSVARIIAHLSRGTTLRKGTVIQTGTPSGVGLFMEPKGFLKDGDVVEVAIDGIGAIRNKMVFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PBG6</accession>
    <name>A0AAN6PBG6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Multiprotein-bridging factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_19345</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Transcriptional coactivator that stimulates GCN4-dependent transcriptional activity by bridging the DNA-binding region of GCN4 and TBP (SPT15), thereby recruiting TBP to GCN4-bound promoters. Involved in induction of the ribosome quality control (RQC) pathway; a pathway that degrades nascent peptide chains during problematic translation. Required to prevent stalled ribosomes from frameshifting.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MBF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854512">
        <property type="protein sequence ID" value="KAK4033743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PBG6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.40:FF:000030">
        <property type="entry name" value="Coactivator bridging factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013729">
        <property type="entry name" value="MBF1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10245:SF15">
        <property type="entry name" value="ENDOTHELIAL DIFFERENTIATION-RELATED FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10245">
        <property type="entry name" value="ENDOTHELIAL DIFFERENTIATION-RELATED FACTOR 1 MULTIPROTEIN BRIDGING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08523">
        <property type="entry name" value="MBF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="9">
        <location>
            <begin position="100"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4033743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="160" mass="17100" checksum="1C4C204CD58767A3" modified="2024-10-02" version="1">MSAWDTETVKIGKNVRSGGGGPRETVVRGSSALNAARRTGAAITTEKKFATGNAVSGVEGQRLTMVDRSDDIVKPKTVGIEVGKAIQKARNEFEQANGNKGLTQKELATKCNTTPTIVAGFERGDATPDQKVLAAMERVLNVKLRGSDIGKPKFEKKEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PBS1</accession>
    <name>A0AAN6PBS1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_18120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854453">
        <property type="protein sequence ID" value="KAK4035164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PBS1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="428"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="473"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="656"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="732"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="844"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="892"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="482"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="548"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="732"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="785"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="892"/>
            <end position="901"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4035164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="982" mass="104978" checksum="D7C04E24CC841B0A" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PBT4</accession>
    <name>A0AAN6PBT4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Mannose-6-phosphate isomerase</fullName>
            <ecNumber evidence="6">5.3.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Phosphohexomutase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Phosphomannose isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">C8A01DRAFT_48249</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-mannose 6-phosphate = D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:12356"/>
            <dbReference type="ChEBI" id="CHEBI:58735"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="5.3.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the mannose-6-phosphate isomerase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.8" evidence="6"/>
    <dbReference type="EMBL" id="MU854440">
        <property type="protein sequence ID" value="KAK4038072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PBT4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004476">
        <property type="term" value="F:mannose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07011">
        <property type="entry name" value="cupin_PMI_type_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.441.10">
        <property type="entry name" value="Phosphomannose Isomerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001250">
        <property type="entry name" value="Man6P_Isoase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016305">
        <property type="entry name" value="Mannose-6-P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046457">
        <property type="entry name" value="PMI_typeI_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00218">
        <property type="entry name" value="manA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10309">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10309:SF4">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20511">
        <property type="entry name" value="PMI_typeI_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00714">
        <property type="entry name" value="MAN6PISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Phosphomannose isomerase type I catalytic" evidence="14">
        <location>
            <begin position="5"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="585"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF20511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK4038072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="604" mass="67295" checksum="729192ED3FD2E00C" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PBX1</accession>
    <name>A0AAN6PBX1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_37947</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854439">
        <property type="protein sequence ID" value="KAK4038109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PBX1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4038109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="106" mass="11235" checksum="17B351D30CD5F256" modified="2024-10-02" version="1">MPSSEPLLAHNNNPDTTTTNKKKKAGLQLAAATPSLWYQGQQQQQQQHPEKVTPAAPPYTAKEAAGFVRLGACMVAWPPEEVWVDPFRGEGAEGVAAGAVLGRGKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PCE3</accession>
    <name>A0AAN6PCE3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_38661</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854462">
        <property type="protein sequence ID" value="KAK4034895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PCE3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="1">
        <location>
            <begin position="6"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4034895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="269" mass="30165" checksum="ACF3652CE3E7A811" modified="2024-10-02" version="1">MATDTFTCFPNLPAELRLMIWEEALSVRTVWAASRAPIKDGSPDSTQPRPLEATFVGPAPYLVGLSCNEARRVMEKSYVQLPSLRGGPSAGHWVDLGKTVVFLGSCEHLLDVLSGFRADEVAQFKHMALNWHWATRSRQVESACRDGLPNLCPALETLIVNRVNQDTLGDPLAPWRSWGPEVSSFYAGLPAYTGRVWEVTTRWDWEDNTFEPSLFGCFPHPFPPGRLRLHMLGQDLKYNIQEKPWRSSDHWVCVARDGGSPVANESSQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PCI4</accession>
    <name>A0AAN6PCI4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_19252</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854506">
        <property type="protein sequence ID" value="KAK4033861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PCI4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.60.10:FF:000034">
        <property type="entry name" value="Universal minicircle sequence binding protein (UMSBP), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.60.10:FF:000060">
        <property type="entry name" value="Zinc knuckle domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051714">
        <property type="entry name" value="Znf_CCHC_NABP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23002">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="10"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="54"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="84"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="129"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="147"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="172"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4033861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="188" mass="18965" checksum="6C6824FBC802CF84" modified="2024-10-02" version="1">MDYSSQGRPCFTCGQTTHQARDCPNKGAAKCYNCGGEGHMSRDCPEGPKDTKTCYRCGQPGHISRDCPTSGGAGGGGGQSGAECYKCGEIGHIARNCSKGGPSYGGGGGGYSGGYGGGGGGFGGGQKTCYSCGGIGHLSRDCVNGNKCYNCGVSGHLSRDCPTASTGGEKICYKCQQPGHVQSQCPNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PCU3</accession>
    <name>A0AAN6PCU3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome P450-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_37440</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854424">
        <property type="protein sequence ID" value="KAK4038604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PCU3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11070">
        <property type="entry name" value="CYP56-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="4 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042982536" evidence="8">
        <location>
            <begin position="18"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="529"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4038604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="599" mass="68470" checksum="6254898898F45FAE" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PCU4</accession>
    <name>A0AAN6PCU4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_48637</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854454">
        <property type="protein sequence ID" value="KAK4035135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PCU4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4035135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="234" mass="26385" checksum="DD50DF54EEC9C20A" modified="2024-10-02" version="1">MNCRAPNHPRSQNEVYALLLRGFSANYRGDPDLARNQSAAIPDERNCSLFIVGLAPDLTTHELLSGITNTGRVYATHINPPDPERGHVRSAAKLVFFERAGAERFYARYSTTGYATPRNPHLRARVTWNRVRSAEVDAGGNRSRVLLISGPPGVVNERFLYAYLDTKMVYQVDEVFRRGQNDDGSRVLVEFRFGSFRCQAEAARMALMREFRDVGVVCDYGELCLCKHELLGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PCX5</accession>
    <name>A0AAN6PCX5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_49169</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854479">
        <property type="protein sequence ID" value="KAK4034463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PCX5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4034463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="483" mass="53642" checksum="1BA3183F44CDC37D" modified="2024-10-02" version="1">MARRKRILFFTNSDFGQANVVLATAHALLHIDPQVEIHIASFRPLEEEVKSTSAFALKAFLHKHSKPIIFHPLDGISWGPATFRPEVGVAATNDLNPGLINSAKNILLIPSVMLPWRPDEFTSLYRQAESILADVQPDVTAIDPIFTPALTLCHHLKTNWLVLAPNTLKDFALPMQPNLAMLWKYPLVCSALPYPLPWSLTPLNILLNLVAAYALLTNPRIRATTAHLRRHTNNPNLSLMTANEMGVLRAPPAGLRVLCAISSDLDYPLSIIPPHLVPCGPIVRAVGPVEGPLREWLARGRTLYVNLGTHLRADVVEAGEMAGALRDVLDRAEAVGYGRLQVLWKLGRKKTVGGEEVERDRFEGKWQGVCDVLRPEIEDGRVKVTDWVDAEPKAVLESGGVVLLPPWSDCYDFANRVEMLGIGRWANKEAKPRWKRDELATCLEDVLFGPEADKIREKARELAMRHPESAGRERAACEILASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PDA5</accession>
    <name>A0AAN6PDA5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">U3 small nucleolar RNA-associated protein 6-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_49310</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UTP6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854487">
        <property type="protein sequence ID" value="KAK4034251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PDA5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013949">
        <property type="entry name" value="Utp6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055347">
        <property type="entry name" value="UTP6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23271">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN 66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23271:SF1">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08640">
        <property type="entry name" value="U3_assoc_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 6 N-terminal" evidence="7">
        <location>
            <begin position="12"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="229"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="229"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4034251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="414" mass="46048" checksum="7BB0804EA138505C" modified="2024-10-02" version="1">MAGVSDKARFYLERAAPELRDFEEKEIFSKDEIRSLVTKRSDYEHLILAPGTKPTDFLSYIAWERSLDRLRAKRCRRLAINRSASSSHASHARTFGIFERAVLKHPGCVPLWRAYLDFAAQEAKATKRWRKICTRALRLHPTDAGLWALAGRRAAQAGDMERARAHFLRGCRFCTGEAALWVEYARCEMEWLARVEAKKGGKGVRKGVNAMEAIRATEAVQEGDVMLFDEDDEDGSDEEGGLVLPDPDAQGQGKKAQPAVFDEEATRKMEQSPALSGAIPMAIFDIAKKQPFFGPAAAETFFDVFAGFGNVPSQERIVQHVLSAMEESFPNHACTCSCQIRQPLIGVDVLTAAFPKALRESLARLKGGMETTQDKKALAGKMVVWIDTILETEGLDEAIKTVLEHTKRSLESTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PDA7</accession>
    <name>A0AAN6PDA7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pisatin demethylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_48994</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854470">
        <property type="protein sequence ID" value="KAK4034658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PDA7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11060">
        <property type="entry name" value="CYP57A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF168">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="4">
        <location>
            <position position="437"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4034658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="489" mass="54568" checksum="113CDB8B23B6E86B" modified="2024-10-02" version="1">MTLVTITAISIGASGPSSSGPSSPAPATAGWSKFWLVRRQFGDKLLQHLLDVSAKYGPIARIAPDWVLVSSHAEIRRIWSVRSGYSRSEWYAGFRFDPNSDSIITMSDNKAHHAVRSRLLAAYQGRGITDQEQVVDAQIVKFIALIERKYVSTRATATEAAQMRPFEMGRRFSYFSQDAISAVVFGEPFGYLDADDDFYGAIDALEGMLLPCNMMALLPPLLAVVTSPLCKPFMPKKTDKHGVGRLLGVIDERVRVRYGEKPVRNMDALQVMVESGLSRQEVEAESLVHLLGGTDTTASALRTAVFFLSTNPAAYRRLQEEIDGVAERVTRPVIADAESKELRFLQACIMESMRCWPPISGLQAKMSSVDDVICGMKVPAGTHIAMSMFGIMRDKEVFGEDAEVFEPMRWLEASPEKLKEMEATQGLCFAAGTRWECLGKRLANIEIRKVLFELFLRFDFAMTDPVNPFTWKHQGFTLHQDMNVTVTKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PDD9</accession>
    <name>A0AAN6PDD9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histone deacetylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_17900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854444">
        <property type="protein sequence ID" value="KAK4035420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PDD9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004407">
        <property type="term" value="F:histone deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="entry name" value="HDAC_Hos3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Histone deacetylase HOS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HDAC_HD_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
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        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47558">
        <property type="entry name" value="HISTONE DEACETYLASE HOS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47558:SF1">
        <property type="entry name" value="HISTONE DEACETYLASE HOS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
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            <begin position="254"/>
            <end position="581"/>
        </location>
    </feature>
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        <location>
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            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
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        </location>
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        </location>
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            <begin position="744"/>
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        </location>
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            <begin position="1"/>
            <end position="11"/>
        </location>
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        <location>
            <begin position="52"/>
            <end position="86"/>
        </location>
    </feature>
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        <location>
            <begin position="117"/>
            <end position="134"/>
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        <location>
            <begin position="648"/>
            <end position="661"/>
        </location>
    </feature>
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        </location>
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        </location>
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        <location>
            <begin position="1160"/>
            <end position="1172"/>
        </location>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK4035420.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1172" mass="124873" checksum="BAB6A7EACF5FA93F" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PDX2</accession>
    <name>A0AAN6PDX2_9PEZI</name>
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        <recommendedName>
            <fullName evidence="5">Mei5 protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">C8A01DRAFT_48202</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854438">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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            <end position="381"/>
        </location>
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            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="353"/>
            <end position="365"/>
        </location>
    </feature>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK4038145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="493" mass="53333" checksum="8B62DDA0CF6F8E30" modified="2024-10-02" version="1">MALPNSSADLAEVENLLRALADKASVKRLAAVVEKNAKLEESNESLLNEKAVVLTLNQRLQNDIASRESQCKKKDDELQSVVQSKKALEAKLSAAEKHLEASVKKAQDLEVKFKRDVEETKSELKESNDELERLGEFFVELKPVNDRGDKIAATLSAVRTSAHSLAVTYFGVDLTPRVLANDDLWEKIGEHNSNGGNLPIPSSNSPLAKQMRVALIFSVLAHELCEHIFQPSYLLKESSGLKKLLTDLAAREPDLESHLRSMLLMASDKINGPVDAKKGACVKAVFDTISGLLSPAIPDSKQGFETDLQNLCVAAFEGWQPIQSLEDHITPELGSKLSKRKYSWKPLAFTLPSPSQPAAAPKQRANGSAPAQGPLKNSLPAATQSRVDETADLADGVAVWPAFVNLSSDAKETLVEGLILPLCLIKAAEEEQMAMPASPTSSHLSHRELRANERNSSMKRRRPSIAATNGHATEGGRKGSFLSNGHGGGPKGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PDX8</accession>
    <name>A0AAN6PDX8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">KOW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_39333</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854490">
        <property type="protein sequence ID" value="KAK4034202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06089">
        <property type="entry name" value="KOW_RPL26"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003256">
        <property type="entry name" value="Ribosomal_uL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041988">
        <property type="entry name" value="Ribosomal_uL24_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12903">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22682">
        <property type="entry name" value="Ribosomal_uL24m-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="KOW" evidence="4">
        <location>
            <begin position="114"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4034202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="391" mass="43980" checksum="7205B8895BAC529C" modified="2024-10-02" version="1">MDKILSRVRMAERQVARRAKRQKALAHHRDIRKARGEILNMTRQAGAELGAAIKARHEDLELGPLAPNRNASKLDKFENYWGAISVDRALLQRDITDAQRDARAAWAGGSRYLCVAVGDRVVVTEGHYKGQISKVTRINKQTMAVELEGNIGVTNAKIPNFLIQDGEPHVQQIKEAIPLSSVRLVHPLTDPATGAARDVIIRELTPVGITHDRPTRKVFFSRVVPGLNVRIPWPKQQPREREAHAGDTLRLDVEERTFVPTLLRPPMPEAVLDELRNRYSKFRTRHTPEYVATVEAREAEKKARRKGARADEMLLPVQEYNRKMRELRRERGRPELSDDMLEKIGEVIVRNRLARSQGAAPAEADVDKVQKAVEELSLGGAQGTGGEQPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PE47</accession>
    <name>A0AAN6PE47_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sialidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_38455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854456">
        <property type="protein sequence ID" value="KAK4035063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PE47"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4035063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="579" mass="62371" checksum="F449A22FC6F2B9AC" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PER6</accession>
    <name>A0AAN6PER6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_17238</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854421">
        <property type="protein sequence ID" value="KAK4038713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PER6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4038713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="185" mass="20803" checksum="4741CCCF275E8D0E" modified="2024-10-02" version="1">MEPLDIAEPRGVPPAGPLRCLIRCRTSRFEQRGKSDVQLVEKLAKRLHLDADKLVHIGTKKNPHRVHIIVDYDNPNHQPCAVRAFKGNSLKDIRLPESAIEYLHWHVGIWNDMIARWGGRFPFQQGDHVELRRKKDCGSSEGALDGRDDSTVEDCDGGKVSLDKPDDGAVKTTEPCQRQEQGAPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PF36</accession>
    <name>A0AAN6PF36_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CAP Gly-rich domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_17020</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TBCB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854415">
        <property type="protein sequence ID" value="KAK4038923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PF36"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035371">
        <property type="term" value="C:microtubule plus-end"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043014">
        <property type="term" value="F:alpha-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01789">
        <property type="entry name" value="Ubl_TBCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045172">
        <property type="entry name" value="TBCB_Ubl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916">
        <property type="entry name" value="DYNACTIN 1-RELATED MICROTUBULE-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916:SF85">
        <property type="entry name" value="TUBULIN-FOLDING COFACTOR B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14560">
        <property type="entry name" value="Ubiquitin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CAP-Gly" evidence="5">
        <location>
            <begin position="182"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4038923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="240" mass="26597" checksum="9E6BA2B6AB4690C5" modified="2024-10-02" version="1">MADVPLYVVSDYSSSERRITPSWSISQLKTKLEPITGIPPSCQQIFLKTSSSEKIAVEAPDEESVYLQQFPLAPYAELLVVDTRPVSARPNFSSTVGVEKYVLPEEEYEKKTDSVLAWKKAEKLGRFDPNAPSHEQAKIAAIAQEIEARGIAVGRRCKIGQDDARRGEIKYVGDVKEIPGLGAWVGVQLDEPVGKNDGSVGGTRYWGEESQLKRGVFVRPERVEAGDFPVLDDLEDMEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PFQ5</accession>
    <name>A0AAN6PFQ5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">tRNA (uracil(54)-C(5))-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">C8A01DRAFT_16846</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNA. May also have a role in tRNA stabilization or maturation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>uridine(54) in tRNA + S-adenosyl-L-methionine = 5-methyluridine(54) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42712"/>
            <dbReference type="Rhea" id="RHEA-COMP:10167"/>
            <dbReference type="Rhea" id="RHEA-COMP:10193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74447"/>
            <dbReference type="EC" id="2.1.1.35"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.35" evidence="5"/>
    <dbReference type="EMBL" id="MU854409">
        <property type="protein sequence ID" value="KAK4039150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PFQ5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030697">
        <property type="term" value="F:tRNA (uracil(54)-C5)-methyltransferase activity, S-adenosyl methionine-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009451">
        <property type="term" value="P:RNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000201">
        <property type="entry name" value="TRM2p tRNA methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000174">
        <property type="entry name" value="TRM2p tRNA methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030390">
        <property type="entry name" value="MeTrfase_TrmA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030391">
        <property type="entry name" value="MeTrfase_TrmA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025795">
        <property type="entry name" value="tRNA_(uracil-5-)_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010280">
        <property type="entry name" value="U5_MeTrfase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11061">
        <property type="entry name" value="RNA M5U METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11061:SF30">
        <property type="entry name" value="TRNA (URACIL(54)-C(5))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01938">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05958">
        <property type="entry name" value="tRNA_U5-meth_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51687">
        <property type="entry name" value="SAM_MT_RNA_M5U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51622">
        <property type="entry name" value="SAM_MT_RNA_M5U_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01230">
        <property type="entry name" value="TRMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01231">
        <property type="entry name" value="TRMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 9 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TRAM" evidence="12">
        <location>
            <begin position="83"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="220"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="494"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="494"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="361"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="395"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="417"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="467"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00052788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00054700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00070108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK4039150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="565" mass="61580" checksum="86A46899C6CB6FD5" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PG36</accession>
    <name>A0AAN6PG36_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Ferric reductase like transmembrane component-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">C8A01DRAFT_17969</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854447">
        <property type="protein sequence ID" value="KAK4035357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PG36"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000293">
        <property type="term" value="F:ferric-chelate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF9">
        <property type="entry name" value="FERRIC REDUCTASE TRANSMEMBRANE COMPONENT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042861523" evidence="9">
        <location>
            <begin position="24"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="372"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="406"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="435"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="461"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Ferric oxidoreductase" evidence="10">
        <location>
            <begin position="334"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="550"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="550"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK4035357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="761" mass="82975" checksum="3A29B3D5BD0B721F" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PH15</accession>
    <name>A0AAN6PH15_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein MEMO1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_47639</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MEMO1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854418">
        <property type="protein sequence ID" value="KAK4038834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PH15"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07361">
        <property type="entry name" value="MEMO_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.830.10">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00055">
        <property type="entry name" value="MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002737">
        <property type="entry name" value="MEMO1_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04336">
        <property type="entry name" value="AmmeMemoSam_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11060">
        <property type="entry name" value="PROTEIN MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11060:SF0">
        <property type="entry name" value="PROTEIN MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01875">
        <property type="entry name" value="Memo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="112"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="112"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4038834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="516" mass="57529" checksum="7D824D89C91D051D" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PH98</accession>
    <name>A0AAN6PH98_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Galactose mutarotase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_47318</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldose epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854408">
        <property type="protein sequence ID" value="KAK4039181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PH98"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004034">
        <property type="term" value="F:aldose 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose, Leloir pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09019">
        <property type="entry name" value="galactose_mutarotase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.10:FF:000015">
        <property type="entry name" value="Aldose 1-epimerase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018052">
        <property type="entry name" value="Ald1_epimerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047215">
        <property type="entry name" value="Galactose_mutarotase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10091">
        <property type="entry name" value="ALDOSE-1-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10091:SF0">
        <property type="entry name" value="GALACTOSE MUTAROTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00545">
        <property type="entry name" value="ALDOSE_1_EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4039181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="341" mass="36315" checksum="7FC08F6AA60AC9B8" modified="2024-10-02" version="1">MADAPVTFLPLGAIIQELRVGGVNIVQGFPEQSHYETLNQPFFGETIGRVANRIKDAKLDALNGGQSYTLAANNGPNNLHGGVVGWGKKIWNGPTPVGVRQIPGVEGLDGGESVKFSLVSQDGDEGFPGTVEATVVYTVGKQVQDGKEVVVLGIEYEAELVGGADETVINMTNHSYFNLTGGPSIEGTVVTLATNSYLPVDDGGIPTGGPKPFSKVEGNKAFTLGAQEPDIDDCFIVNEAPATVPIDTRSKPLTKLVSAHHPASNIHLEVLSTEPAFQFYTGKYISVPEVAGVAARGARSGFCVEPSRWVNACNVDEWKGQMLLKKGEKYGCRIVYRAWKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PHB2</accession>
    <name>A0AAN6PHB2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_45794</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854366">
        <property type="protein sequence ID" value="KAK4040968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PHB2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF15">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="42"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4040968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="318" mass="35206" checksum="260342377D3D5D61" modified="2024-10-02" version="1">MADRDVALDECLLTHIFASNQPSSVSVILRNWDKCTLQVGSAANEQGREFQFSMMELVEGITLEEVWDHMTGENRASVATAVAEAISKMYSVRLSDAKVQSILRRALGERSEEVLEKAVLGGPSTGFLNDGPSLLSATIHPIPEPKGLVIQSEFEDLGSTTVSDSDMEHWPKEAVFCHNDLTPRNLMLQPTGSAGGITSYKLAAIIDWELAGFYPPSYQLSLQDTYLSGGNRHLSFYLLLKERLKDITPPSPSHLRRFGEMLGLSRDEDPYVGWKCEAGAASPPEFSREDAQRLEDDVVAEMIRRRQAKAKPGELHNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PHK8</accession>
    <name>A0AAN6PHK8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Conserved oligomeric Golgi complex subunit 6</fullName>
            <shortName evidence="13">COG complex subunit 6</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 13">Component of oligomeric Golgi complex 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">C8A01DRAFT_45748</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Acts as a component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events.</text>
    </comment>
    <comment type="function">
        <text evidence="13">Acts as component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the conserved oligomeric Golgi complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Golgi apparatus membrane</location>
            <topology evidence="1 13">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the COG6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854365">
        <property type="protein sequence ID" value="KAK4041021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
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</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
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                <person name="Kuo A."/>
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                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
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                <person name="Calhoun S."/>
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                <person name="Riley R."/>
                <person name="LaButti K."/>
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                <person name="Lipzen A."/>
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                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
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                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
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                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
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                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        </location>
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        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="223" mass="23903" checksum="23B02C97CC8EE406" modified="2024-10-02" version="1">MGCRASLFSLAAAVTSLQAVSAAAVDPRDAPALIRWEGPVFAGERDKTLYVTDVGDLWNKVLDMNPQWVAEVADLDETNHEFGVPSVCGADSGIATGNSDEVTHILTRLRALKGYWTLGAGRCHRLGCGQNTGVYWCNDNAWGIRTSAKALYLRGSHIRDICCHRRDGSLYSGDPMSGVEAFPDNDPEAAHSRVAVGYGSCVDNNAVLPLVYTFPGKLGACRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAN6PI32_9PEZI</name>
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        <recommendedName>
            <fullName evidence="4">Tyrosinase copper-binding domain-containing protein</fullName>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
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                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854401">
        <property type="protein sequence ID" value="KAK4039389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PI32"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF125">
        <property type="entry name" value="N-ACETYL-6-HYDROXYTRYPTOPHAN OXIDASE IVOB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042906162" description="Tyrosinase copper-binding domain-containing protein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="4">
        <location>
            <begin position="324"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4039389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="415" mass="45442" checksum="2B96C288B9FAEE52" modified="2024-10-02" version="1">MRGIQSVASLSLLIGAWAGPVAKKWESNAARNPAYPLDVVDKLEESIMPIVEAWMAKRAGKSNNCTLENAAVRREWSDLSVDERKEYIRAVLCLQSKPAKAPKDTVPGALSRFDDFVATHMTMAGTLHSPTNLFAAHRYFIHVYEKALREECGYKGYQPYMNYDRYADDPIHSPMFDGSDSSMGGNGAPSEYPGISQPFPQPYSMMPSAGGGGCVTQGPFKDMVVSLGPKSTIVRNIPANPRADGLGSNPRCLRRDVNRHSAAGARANYTYSTIVDNKDIDAFYNRYLGQPQLKGDTHPWGIHNAGHYIIGGDPGGDFYCSPGDPAFYFHHGMLDRVWWIWQMQDPDARVHAVPGQAAMPMPSHGSGGGGMGMKEKRADIHDAVVDLGWTAPPVKLMDLNEQLGGLGGELCYIYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PIB4</accession>
    <name>A0AAN6PIB4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">homogentisate 1,2-dioxygenase</fullName>
            <ecNumber evidence="4">1.13.11.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">C8A01DRAFT_47412</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 4/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the homogentisate dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.5" evidence="4"/>
    <dbReference type="EMBL" id="MU854411">
        <property type="protein sequence ID" value="KAK4039085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PIB4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004411">
        <property type="term" value="F:homogentisate 1,2-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07000">
        <property type="entry name" value="cupin_HGO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000053">
        <property type="entry name" value="Homogentisate 1,2-dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046522">
        <property type="entry name" value="DUF6699"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046451">
        <property type="entry name" value="HgmA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046452">
        <property type="entry name" value="HgmA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005708">
        <property type="entry name" value="Homogentis_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01015">
        <property type="entry name" value="hmgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11056">
        <property type="entry name" value="HOMOGENTISATE 1,2-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11056:SF0">
        <property type="entry name" value="HOMOGENTISATE 1,2-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20415">
        <property type="entry name" value="DUF6699"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04209">
        <property type="entry name" value="HgmA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20510">
        <property type="entry name" value="HgmA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="9 12" id="KW-0408">Iron</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="DUF6699" evidence="14">
        <location>
            <begin position="64"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Homogentisate 1,2-dioxygenase N-terminal" evidence="15">
        <location>
            <begin position="171"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Homogentisate 1,2-dioxygenase C-terminal" evidence="13">
        <location>
            <begin position="458"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="469"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="512"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="518"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="527"/>
        </location>
        <ligand>
            <name>homogentisate</name>
            <dbReference type="ChEBI" id="CHEBI:16169"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="551"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="551"/>
        </location>
        <ligand>
            <name>homogentisate</name>
            <dbReference type="ChEBI" id="CHEBI:16169"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605708-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605708-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF20415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF20510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK4039085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="620" mass="68602" checksum="AEB93248B2F6A137" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PID7</accession>
    <name>A0AAN6PID7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosomal RNA methyltransferase FtsJ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_16463</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854397">
        <property type="protein sequence ID" value="KAK4039554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PID7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="1">
        <location>
            <begin position="143"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4039554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="418" mass="46360" checksum="3B3AB597F6B0D474" modified="2024-10-02" version="1">MSSHSAGAVLNQIPSPNRTLFSSAHLRVGTQEVNSMGEISECKASPGPANNSNATPRVQPKTLLQEYLLEHLPIYRKLRELQRLGWQSEAGDTHFQNQRQRADHADAKAKTGFFRLMRTIGLELDDATLALTLPSGGNSPRPAILDLCMAPGGFSSAALYRNPAALLRGISLPPSQGGHEMLLNKYWSDRDPSAQIYVSFRDITLLAEEMGTPASSVPASHPDAASFSSDRPFMDQEFDLVFCDGQVLRTHERLEYRQKTEATRLLTTQLVLALQRIRPGGTIVILLHKADAWPSVQLMHTFAAFADGVELFKPRAGHRVRSSFYLVAKGVRPWREAAVEAVRRWKVQWSVATFGVQGGRGDERLSGEEELELLEGGEEEEVRAVLRKFGPALVRMVEPVFAIQAEALRNAPWMKNMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PIH6</accession>
    <name>A0AAN6PIH6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_14776</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854356">
        <property type="protein sequence ID" value="KAK4041486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PIH6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4041486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="66" mass="6956" checksum="1223554372B3CAF5" modified="2024-10-02" version="1">MCTEHHSSVCPACGKDYLVYVEFCKAFHPPLVTCPTGTVAVRIPMEQGGCPSRICPNSPGGGCALM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PIR8</accession>
    <name>A0AAN6PIR8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NIPSNAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_34459</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NipSnap family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854356">
        <property type="protein sequence ID" value="KAK4041507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PIR8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000004">
        <property type="entry name" value="NIPSNAP family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000037">
        <property type="entry name" value="NIPSNAP family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012577">
        <property type="entry name" value="NIPSNAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051557">
        <property type="entry name" value="NipSnap_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21017">
        <property type="entry name" value="NIPSNAP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21017:SF17">
        <property type="entry name" value="PROTEIN NIPSNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07978">
        <property type="entry name" value="NIPSNAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NIPSNAP" evidence="3">
        <location>
            <begin position="178"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="NIPSNAP" evidence="3">
        <location>
            <begin position="265"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="29"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="67"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4041507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="364" mass="40787" checksum="048327AC5EB5C389" modified="2024-10-02" version="1">MLSQRVVRAATAARQAPAIRTFTTSVATRSDRTPALGDIQPDKHETFNSRQKTFRAQLVEAQKQREASGFASSSPLSSSSTSSSSSSSSAQGLGSLSTAAAGTGNAARAADHQPPRKAGPLTNLIYGTKEGRELDAQIEASFSQVLARGKYVHSIEFHDVKPECVDEYVALVGKWYPRVASAAENKVHLVGSWRTEVGDCDTFVHIWEYQRYQGFHASLNTISRNAQFPDFDKQLRGLIRGKRTSLMQEFSFWPTTPPRQLGGLFELRSYTLHPGNLLEWETHWRRGLKARREVMEGVGAWFVQIGDLNTVHHLWQFADLEERKIRREKSWGIEGWAETVHKTVPLIQEMKSRILVPMPWSPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PIS9</accession>
    <name>A0AAN6PIS9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">C8A01DRAFT_34510</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854357">
        <property type="protein sequence ID" value="KAK4041427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PIS9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11058">
        <property type="entry name" value="CYP60B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF230">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="17"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="454"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK4041427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="511" mass="57442" checksum="CD2827F51DE2FAF0" modified="2024-10-02" version="1">MINLQNLLSEATSNTTLLLGSVVILLLTYPLTTLTYNLLLHPLRHFPGPVLHRASALPWALRHALGTSAFHTQKLHARYGPVVRIAPGHLSFTSPRAWHDIYNALPRDGGSVWPEMPKSKVFTSATDDQEESIIQAGFHEHARLRRALAPGFSDAALRVQEPVLRGYVDLLVGKMREKCEEGGGAVLDMEQWYNWATFDIAGDLVWGRAFGCLEREEYHPWIAFIMGTLKAAAAMVSIIYLGGRWLVRILFKTVGQKSILTLRRMTEEMVSHRLAMEKGKDDLFEGLVKHREEWSLSLEKFSSNGLILTLAGSETLATSLCGMTYLLLENPSTMETLTRELRAAFESADDITVKAVSRLPYLTAVINESLRMYPPVVADLIRVVPPEGKQIAGHYVVGGTFVEVQPWSINHSPDNWVDPWTFNPDRFLPSEDEAREAGNVLEASQAFSWGPRNCLGRNLAYAEMRLILARLVYEFDMKLGEGSDNWIGRQKTFPLWDRLPLNVHCTPVRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PIU5</accession>
    <name>A0AAN6PIU5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_34171</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854351">
        <property type="protein sequence ID" value="KAK4041793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PIU5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10527">
        <property type="entry name" value="SET_LSMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF76">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="23"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4041793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="491" mass="53401" checksum="A23AC8EC7E3488F2" modified="2024-10-02" version="1">MHRPTLPIEGLPAWAHLNDVSFHGVKVVNTEGKGYGVVSDTDLEATDDTSDAPALLTVPHDLVLNAAAVEEYAKEDKNFRQLLDAIGRRSTRADVLLFLLVQTVLASRSGHSAVGVSNPWTEYLKFLPETVLVPTLWTEDERLLLRGTSLEAAVDAKISALDAEFGLVQEKSSDIISWNDLLWAEGASVSFTDWIRLDALYRSRCLELPRSGESMVPCVDMLNHSAAPSAYYDETPKDEVILLPRPGTTGIPKGAEITISYGADKSAAEMLFSYGFIDPGSTADSLVLPLAPFPDDPLAKAKLVAFGEAPQIHVAREEEEAGNGLAAVRWASAFAHLMCVNEEDGLEFRVLQQTDGARQLRVFWQEEDVTDQAGEFEALVQTHPLAAVVRLRVVTVVQEALRAQLERLGSAVAVPAAAAASPQQRREDCVRAAMLLREIETKLLEAAVETLEEERSSLLTDRNVVAYLGLTEAAESGLAGDEVSNEPDDFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PIV8</accession>
    <name>A0AAN6PIV8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Tyrosinase copper-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_47161</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854402">
        <property type="protein sequence ID" value="KAK4039370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PIV8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF125">
        <property type="entry name" value="N-ACETYL-6-HYDROXYTRYPTOPHAN OXIDASE IVOB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00497">
        <property type="entry name" value="TYROSINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042939553" description="Tyrosinase copper-binding domain-containing protein" evidence="4">
        <location>
            <begin position="24"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="5">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="6">
        <location>
            <begin position="300"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="204"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4039370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="376" mass="40798" checksum="2073A2CFCF2F70D7" modified="2024-10-02" version="1">MARLTLVGLLAVPWLLLAGLVSGDAVLDLQTKGRPSIDAQIAKSTTCTKANLKVRREWGDISAAEKKAYIAAMLCIMQKPSKLDSTKFPGAKSRYDDFVVVHMNQTLSIHGTGNFLSWHRYYTWAFERVLQQECGYTGTQPYWDWGRWAQDPEKSPIFDGSDTSLSGNGEKIQHRASGAVPAGNGGGCVKTGPFKDMVVHLGPVSPSVDPAPPRNPRTDGYGDNPRCLRRDISNQLSSKYSRTQDIVSLITASKDLATFQTVMQGAGGFGVGGGGMGVHSAGHFTIAGDPGGDFYTSPNDPAFWVHHGMIDRTWTIWQSQDLASRTQIVSGGTSMMGGGRQQSLDDLVDLGVVADKVYRIRDLVSVVDGPFCYVYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PJ78</accession>
    <name>A0AAN6PJ78_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">lytic cellulose monooxygenase (C4-dehydrogenating)</fullName>
            <ecNumber evidence="15">1.14.99.56</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">C8A01DRAFT_15113</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the polysaccharide monooxygenase AA9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="15"/>
    <dbReference type="EMBL" id="MU854363">
        <property type="protein sequence ID" value="KAK4041098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PJ78"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF9">
        <property type="entry name" value="ENDOGLUCANASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042891847" description="lytic cellulose monooxygenase (C4-dehydrogenating)" evidence="16">
        <location>
            <begin position="21"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="17">
        <location>
            <begin position="33"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAK4041098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="243" mass="25340" checksum="F400A210A741043C" modified="2024-10-02" version="1">MKSCSTALFAAGLLAQYATAHSIFQQAGSGSTDFDTKCTRMPPSNSPVTSVTSADMTCNVGGSKGVAGFCEVNAGDEFTVEMHAQPNDRSCDKEAIGGNHFGPVMVYMSKVDDASATDASGASWFKVDEFGYDAASKTWGTDKLNANCGKRSFKIPSKIPAGDYLVRAEAIALHTAGQSGGAQFYMSCYQVKIAGGEGGQLPAGVKIPGAYSATDPGILVDIWGNGFSEYTIPGPAVIDQSYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PJD4</accession>
    <name>A0AAN6PJD4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA repair protein RAD51 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">C8A01DRAFT_33841</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required both for recombination and for the repair of DNA damage caused by X-rays.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the RecA family. RAD51 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854346">
        <property type="protein sequence ID" value="KAK4042078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PJD4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070192">
        <property type="term" value="P:chromosome organization involved in meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000730">
        <property type="term" value="P:DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042148">
        <property type="term" value="P:DNA strand invasion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990426">
        <property type="term" value="P:mitotic recombination-dependent replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19513">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000008">
        <property type="entry name" value="DNA repair protein RAD51 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000092">
        <property type="entry name" value="DNA repair protein Rad51 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011941">
        <property type="entry name" value="DNA_recomb/repair_Rad51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016467">
        <property type="entry name" value="DNA_recomb/repair_RecA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010995">
        <property type="entry name" value="DNA_repair_Rad51/TF_NusA_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020587">
        <property type="entry name" value="RecA_monomer-monomer_interface"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003301">
        <property type="entry name" value="PRK04301.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02239">
        <property type="entry name" value="recomb_RAD51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942:SF39">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942">
        <property type="entry name" value="RECA/RAD51/RADA DNA STRAND-PAIRING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14520">
        <property type="entry name" value="HHH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005856">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47794">
        <property type="entry name" value="Rad51 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50163">
        <property type="entry name" value="RECA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="9">
        <location>
            <begin position="101"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="RecA family profile 2" evidence="10">
        <location>
            <begin position="281"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK4042078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="350" mass="37548" checksum="CE9B2F149B7B0BB6" modified="2024-10-02" version="1">MSGQEEYDDTANAEDVGQTGPGAPTPLSALEGVAGLTKRDIQAIVEGGYNTVESVAYTPQRMLEQIKGISAQKAAKILGEASKLVPMGFTTATEMHQRRSELISITTGSKQLDTLLAGGIETGSVTELFGEFRTGKSQICHTLAVTCQLPFDMGGGEGKCLYIDTEGTFRPVRLLAVANRYGLSGEEVLDNVAYARAYNSDHQLQLLNQAAAMMCETRFSLLIVDSATALYRTDFLGRGELSSRQTHLAKFLRTLQRLADEFGIAVVITNQVVAQVDGGPSAMFNPDPKKPIGGNIIAHASTTRISLKKGRGETRIAKIYDSPCLPEGDALFAINEDGIGDPSPKDLEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PJN3</accession>
    <name>A0AAN6PJN3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Carbamoyl phosphate synthase arginine-specific large chain, mitochondrial</fullName>
            <ecNumber evidence="14">6.3.4.16</ecNumber>
            <ecNumber evidence="5">6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Ammonium-dependent carbamoyl phosphate synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Arginine-specific carbamoyl phosphate synthetase, ammonia chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Glutamine-dependent carbamoyl phosphate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">C8A01DRAFT_33880</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>hydrogencarbonate + L-glutamine + 2 ATP + H2O = carbamoyl phosphate + L-glutamate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>hydrogencarbonate + NH4(+) + 2 ATP = carbamoyl phosphate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18029"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Heterodimer composed of 2 chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CarB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.16" evidence="14"/>
    <dbReference type="EC" id="6.3.5.5" evidence="5"/>
    <dbReference type="EMBL" id="MU854346">
        <property type="protein sequence ID" value="KAK4042116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PJN3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004087">
        <property type="term" value="F:carbamoyl-phosphate synthase (ammonia) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01423">
        <property type="entry name" value="MGS_CPS_I_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000004">
        <property type="entry name" value="Carbamoyl-phosphate synthase (glutamine-hydrolyzing)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1380:FF:000015">
        <property type="entry name" value="Carbamoyl-phosphate synthase arginine-specific large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1030.10:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000002">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1030.10">
        <property type="entry name" value="Carbamoyl-phosphate synthetase, large subunit oligomerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="entry name" value="Methylglyoxal synthase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036897">
        <property type="entry name" value="CarbamoylP_synth_lsu_oligo_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005483">
        <property type="entry name" value="CPSase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006275">
        <property type="entry name" value="CPSase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005480">
        <property type="entry name" value="CPSase_lsu_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058047">
        <property type="entry name" value="CPSase_preATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01369">
        <property type="entry name" value="CPSaseII_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003671">
        <property type="entry name" value="PRK05294.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009455">
        <property type="entry name" value="PRK12815.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405:SF53">
        <property type="entry name" value="CARBAMOYL-PHOSPHATE SYNTHASE [AMMONIA], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405">
        <property type="entry name" value="CARBAMOYLTRANSFERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25596">
        <property type="entry name" value="CPSase_L_D1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02787">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00098">
        <property type="entry name" value="CPSASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01096">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48108">
        <property type="entry name" value="Carbamoyl phosphate synthetase, large subunit connection domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="Methylglyoxal synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="12" id="KW-0464">Manganese</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ATP-grasp" evidence="22">
        <location>
            <begin position="218"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="22">
        <location>
            <begin position="755"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="domain" description="MGS-like" evidence="23">
        <location>
            <begin position="1020"/>
            <end position="1169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00044318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00068891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KAK4042116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1169" mass="128611" checksum="1577B670B1E09478" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PJR6</accession>
    <name>A0AAN6PJR6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mitochondrial glycine transporter</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Solute carrier family 25 member 38 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">C8A01DRAFT_36241</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the miochondrial matrix.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>glycine(in) = glycine(out)</text>
            <dbReference type="Rhea" id="RHEA:70715"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion inner membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854392">
        <property type="protein sequence ID" value="KAK4039790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PJR6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015187">
        <property type="term" value="F:glycine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904983">
        <property type="term" value="P:glycine import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03064">
        <property type="entry name" value="SLC25A38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030847">
        <property type="entry name" value="Hem25/SLC25A38"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46181">
        <property type="entry name" value="MITOCHONDRIAL GLYCINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46181:SF3">
        <property type="entry name" value="MITOCHONDRIAL GLYCINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 10 12" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="10"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="116"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="227"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK4039790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="324" mass="34178" checksum="B70F736197F079B1" modified="2024-10-02" version="1">MSDGSRTALSKSTFHFAAGLGSGVLSAVLLQPIDLLKTRVQQSGAHSLAAAIADIRAAPRLLPALWRGAVPSALRTGFGSAIYFTSLNAIRTSAARISPITPGSGGNSTSSSLPKLSNTSNLLSGAVARSLAGLLLMPLTVLKVRYESTLYNYTSLASAARDIATKEGPRGFFAGYGATAVRDAPYAGLYVLFYEQSKKRLSVLFPAAGEGTDRGGGNDNKGMALSHAAGINFSSGVFSGVVCSVISNPFDAVKTRIQLQPGQYRNMVQGARRMVGEEGVRALWDGLALRMSRKAVSSALAWTVYEELIRRAETGWQARARDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PK05</accession>
    <name>A0AAN6PK05_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">chitinase</fullName>
            <ecNumber evidence="3">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">C8A01DRAFT_14736</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the glycosyl hydrolase 16 family. CRH1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="3"/>
    <dbReference type="EMBL" id="MU854356">
        <property type="protein sequence ID" value="KAK4041488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PK05"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02183">
        <property type="entry name" value="GH16_fungal_CRH1_transglycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF27">
        <property type="entry name" value="GLYCOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042846150" description="chitinase" evidence="15">
        <location>
            <begin position="26"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="304"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="16">
        <location>
            <begin position="22"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="359"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="427"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="368"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="390"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="427"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="532"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAK4041488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="562" mass="60415" checksum="6E8A2F2EB3ED9044" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PK30</accession>
    <name>A0AAN6PK30_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_14012</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854342">
        <property type="protein sequence ID" value="KAK4042341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PK30"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4042341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="217" mass="23929" checksum="B974E5CC4DE6BCD2" modified="2024-10-02" version="1">MAGSVTTSAISPGISPGMAYRPLNFPSLYGSDTDDERRWTLSFNLATVFRVLVTVAALADIITWSRMGPIHSTVLVVFVELFIVLGWNVVLLLPQSRVTRVLPAVVCQIGDCDCVFNSDDDEEGWPRKPKNKQQKRWKLLFTALVDLVLGLTTTIIMSDGLELILAVISLVACFWTLDLELGVHLRHIDEPETHIRIQLAPDTDDRRTAGGTVSVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PKA0</accession>
    <name>A0AAN6PKA0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_13858</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SH3BGR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854339">
        <property type="protein sequence ID" value="KAK4042558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PKA0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006993">
        <property type="entry name" value="Glut_rich_SH3-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051033">
        <property type="entry name" value="SH3BGR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12232">
        <property type="entry name" value="SH3 DOMAIN-BINDING GLUTAMIC ACID-RICH-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12232:SF0">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04908">
        <property type="entry name" value="SH3BGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="118"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="257"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="294"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="310"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4042558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="374" mass="40143" checksum="E81D7C4C4B1EB971" modified="2024-10-02" version="1">MASENSEAKSYSTDPALYIYTSLTAGSSHIVTATSRLETILRANRVPFKALDIATDEKARMLWGRRAGKDAGGRQRKLPGLVQMGMVLGDLTEIEEWNEYGELKQNVTIYYDEFTQPSISQAPKQPPAAAPKAPPAPPAPAPAPKSPAETAMAAAASAAAAKATLPVRSIAEEAAAKAKQVHLQSLRDKVYGKGNTSPSTEKTTTKTPTAPTPTTETKRETKSPTPSDNNDNKKPTSPAAGLQSPTSSGWKPPSAPPTAQSPTTTSWKPRDVDAPVTELHGSVVLPASAEEIAAVERAETIREEPGREESSEEEGDDDDDDDDDDEEEEEDDEEEDDDEEEEEEEEEEEDDDDEEEEVKGKVAGKAGEVKGKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PKY8</accession>
    <name>A0AAN6PKY8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CEN-like protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_33022</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854334">
        <property type="protein sequence ID" value="KAK4042918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PKY8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030414">
        <property type="term" value="F:peptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030162">
        <property type="term" value="P:regulation of proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046578">
        <property type="term" value="P:regulation of Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035810">
        <property type="entry name" value="PEBP_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362:SF141">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042951186" evidence="1">
        <location>
            <begin position="18"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4042918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="279" mass="27133" checksum="CB85A24C6018C9CD" modified="2024-10-02" version="1">MVSKCLAALVAAATVLARTPAGFTPSSETDLVVEYNGFAPLNGVVVSRSVTTSQPRIGTRARLNGTSYAVMMIDLDIPTNNPPETNTLLHWMQTGLTPATAPTTLNTTAGTISAFLLEPRSSSSNSTTGAAAAAAAVAEAIRPYSGPNPPARVPLSHRYTQILVDTSGLTAQGVEALRGAAATIRGFDAGTALAAAGLEGRVVAGNSYNVTNAGPALAPNATTGGGAGGGGGGGSASGTGVIGGGASQTAVLPGAGVGLRPGSVVLGGLVAVGMVAVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PL17</accession>
    <name>A0AAN6PL17_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">V-type proton ATPase proteolipid subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">C8A01DRAFT_13596</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Proton-conducting pore forming subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11 12">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1). The decameric c-ring forms the proton-conducting pore, and is composed of eight proteolipid subunits c, one subunit c' and one subunit c''.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Vacuole membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the V-ATPase proteolipid subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854335">
        <property type="protein sequence ID" value="KAK4042866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PL17"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18175">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18176">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.610:FF:000003">
        <property type="entry name" value="V-type proton ATPase proteolipid subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="entry name" value="lithium bound rotor ring of v- atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000245">
        <property type="entry name" value="ATPase_proteolipid_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011555">
        <property type="entry name" value="ATPase_proteolipid_su_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01100">
        <property type="entry name" value="V_ATP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10263">
        <property type="entry name" value="V-TYPE PROTON ATPASE PROTEOLIPID SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00122">
        <property type="entry name" value="VACATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <keyword evidence="4 12" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="132"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="13">
        <location>
            <begin position="18"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="13">
        <location>
            <begin position="98"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00045519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00046480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK4042866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="163" mass="16793" checksum="403503DA05B64440" modified="2024-10-02" version="1">MNESEFSPKFAPFIGMGGIAAAMIFGCMGAAYGTAKSGIGIAGVGTFRPDLIMKCLIPVVMSGIIAVYSLVISVLIAQDLAPPGQGSNYSLFNGFMHLACGLSVGLTGLAAGYCIGIVGDKGVRSYMLQSRVFVGMVLILIFGEVLGLYGLIVALILNTKSKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PLG1</accession>
    <name>A0AAN6PLG1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_13515</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854334">
        <property type="protein sequence ID" value="KAK4042912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PLG1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000039">
        <property type="entry name" value="Esterase ybfF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46118">
        <property type="entry name" value="PROTEIN ABHD11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46118:SF4">
        <property type="entry name" value="PROTEIN ABHD11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="70"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4042912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="313" mass="34294" checksum="BE59F870E4500E0B" modified="2024-10-02" version="1">MIGLAPSASAFSRACFGSPRRVRIPVSASAPAPTRLLAAGAQASSPFSTVPLAYDLHEPAKPVADKQTSPIIFMHGLFGSKKNNRTVSKHVYAVDLRNHGESPHDHRHDYPAMAADVADFIRQHGLKEPTLIGHSMGAKTAMALALHEPDLVANLVAVDNAPVDARLGSDFARYIQGMKKIDEAGITRQAEADKILEPYEKSLAVRQFLLGNLHRASADTKTQTFRVPLPILARALDHLGDFPFKSPGEVRFAKPALFIRGTQSKYVPDEVIPLIGQFFPRFELVDVDAGHWVISEKPEAFREAVIQFLEPKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PLX1</accession>
    <name>A0AAN6PLX1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Intradiol ring-cleavage dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_13265</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the intradiol ring-cleavage dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854330">
        <property type="protein sequence ID" value="KAK4043232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PLX1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018576">
        <property type="term" value="F:catechol 1,2-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009712">
        <property type="term" value="P:catechol-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03461">
        <property type="entry name" value="1_2-HQD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.130.10">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039390">
        <property type="entry name" value="1_2-HQD/HQD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007535">
        <property type="entry name" value="Catechol_dOase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000627">
        <property type="entry name" value="Intradiol_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015889">
        <property type="entry name" value="Intradiol_dOase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050770">
        <property type="entry name" value="Intradiol_RC_Dioxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33711">
        <property type="entry name" value="DIOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33711:SF7">
        <property type="entry name" value="INTRADIOL RING-CLEAVAGE DIOXYGENASES DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00775">
        <property type="entry name" value="Dioxygenase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04444">
        <property type="entry name" value="Dioxygenase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49482">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00083">
        <property type="entry name" value="INTRADIOL_DIOXYGENAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Intradiol ring-cleavage dioxygenases" evidence="8">
        <location>
            <begin position="164"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4043232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="313" mass="34588" checksum="FA034014B1BDF25C" modified="2024-10-02" version="1">MGQMIPDPAPRAPVGLKPNGVSKQPQYDATFTDRVISATGPNANRRLAEVMPSLVRHLHAFAREVNLTVAEWIAAVEFINECGKMSDDRRNETQLLCDIVGLESLVDEITSKMLATSKSETPSAILGPFYRHDAPLLPNGSSIVRNLSPSVPWYEQAVADSAFVTGRVLSSSGAPIKGASVDVWHSAPNGLYEQQDESQPDMNFRGRFETDAEGCYAFYALRPVPYPIPDDGPAGRLLNLLDRHPYRPGHIHFIVSAPGFRALTTQLYDDRDEYIAKDAVFAVKDELVVKFAPREGDPNARWSLDYDFVLGRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PMB0</accession>
    <name>A0AAN6PMB0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cofilin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Actin-depolymerizing factor 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">C8A01DRAFT_43528</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the actin-binding proteins ADF family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the chaperonin (HSP60) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854326">
        <property type="protein sequence ID" value="KAK4043586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PMB0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016363">
        <property type="term" value="C:nuclear matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030042">
        <property type="term" value="P:actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11286">
        <property type="entry name" value="ADF_cofilin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03344">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000001">
        <property type="entry name" value="60 kDa chaperonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000001">
        <property type="entry name" value="60 kDa chaperonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00600">
        <property type="entry name" value="CH60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017904">
        <property type="entry name" value="ADF/Cofilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018370">
        <property type="entry name" value="Chaperonin_Cpn60_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001844">
        <property type="entry name" value="Cpn60/GroEL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02348">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000592">
        <property type="entry name" value="PRK00013.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009487">
        <property type="entry name" value="PRK12849.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009488">
        <property type="entry name" value="PRK12850.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009489">
        <property type="entry name" value="PRK12851.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45633">
        <property type="entry name" value="60 KDA HEAT SHOCK PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00298">
        <property type="entry name" value="CHAPERONIN60"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00296">
        <property type="entry name" value="CHAPERONINS_CPN60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADF-H" evidence="11">
        <location>
            <begin position="574"/>
            <end position="720"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK4043586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="726" mass="77128" checksum="49AC0634BD348F3D" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PMQ9</accession>
    <name>A0AAN6PMQ9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">arginine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Arginyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">C8A01DRAFT_45488</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>tRNA(Arg) + L-arginine + ATP = L-arginyl-tRNA(Arg) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20301"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.19"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.19" evidence="3"/>
    <dbReference type="EMBL" id="MU854359">
        <property type="protein sequence ID" value="KAK4041335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PMQ9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07956">
        <property type="entry name" value="Anticodon_Ia_Arg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000006">
        <property type="entry name" value="Arginyl-tRNA synthetase 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000058">
        <property type="entry name" value="Mitochondrial arginyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.70">
        <property type="entry name" value="Arginyl tRNA synthetase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001278">
        <property type="entry name" value="Arg-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005148">
        <property type="entry name" value="Arg-tRNA-synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036695">
        <property type="entry name" value="Arg-tRNA-synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035684">
        <property type="entry name" value="ArgRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008909">
        <property type="entry name" value="DALR_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00456">
        <property type="entry name" value="argS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956:SF11">
        <property type="entry name" value="ARGININE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956">
        <property type="entry name" value="ARGINYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05746">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00750">
        <property type="entry name" value="tRNA-synt_1d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01038">
        <property type="entry name" value="TRNASYNTHARG"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01016">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00836">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55190">
        <property type="entry name" value="Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 20" id="KW-0436">Ligase</keyword>
    <keyword evidence="13 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="19">
        <location>
            <begin position="302"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="528"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00033033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAK4041335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1217" mass="136660" checksum="DCEC4CE8E9BB4DCE" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PNS5</accession>
    <name>A0AAN6PNS5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_31420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854319">
        <property type="protein sequence ID" value="KAK4044366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PNS5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40636">
        <property type="entry name" value="CSBD-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40636:SF1">
        <property type="entry name" value="CSBD-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4044366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="92" mass="8694" checksum="8C29CAA1E5A4184E" modified="2024-10-02" version="1">MSDKNNNSGITGAGKVVTSTLGNTVGGLANTVGGVVGAASRGIGETVNSATGGIGRPLGDGIANVGTGVEGGVASVAQGVKDAGEWKTNPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PNX0</accession>
    <name>A0AAN6PNX0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">OPT oligopeptide transporter protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">C8A01DRAFT_14391</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854349">
        <property type="protein sequence ID" value="KAK4041950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PNX0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00727">
        <property type="entry name" value="ISP4_OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="274"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="409"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="473"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="510"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="543"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="614"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="715"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="742"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="772"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="824"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="896"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="980"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="658"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="73"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="124"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="155"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="660"/>
            <end position="669"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK4041950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1035" mass="114274" checksum="9B752B10E82D476A" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PPH7</accession>
    <name>A0AAN6PPH7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_30967</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854316">
        <property type="protein sequence ID" value="KAK4044786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PPH7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000036">
        <property type="entry name" value="Inositol polyphosphate phosphatase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF240">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE 5-PHOSPHATASE C9G1.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inositol polyphosphate-related phosphatase" evidence="2">
        <location>
            <begin position="799"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="416"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4044786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1208" mass="132778" checksum="6EB931EEA5507A35" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PPM1</accession>
    <name>A0AAN6PPM1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein SnodProt1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_31091</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cerato-platanin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854316">
        <property type="protein sequence ID" value="KAK4044904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PPM1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd22778">
        <property type="entry name" value="DPBB_CEPL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010829">
        <property type="entry name" value="Cerato-platanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07249">
        <property type="entry name" value="Cerato-platanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043053960" evidence="4">
        <location>
            <begin position="19"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4044904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="138" mass="14710" checksum="4C057A8E80B75AED" modified="2024-10-02" version="1">MQFSKILSIFSLAAAASATTVSYDVGYDDGNRPLTSVACSDGTNGLIWRYNWNYQRDVARFPYIGGAQAIGGWNSPSCGSCWSATYNGRTIHILAIDHAASGLNMGLTAMNDLTNGHAVELGRIEATVQQVDLSNCGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PPM4</accession>
    <name>A0AAN6PPM4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_13779</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854338">
        <property type="protein sequence ID" value="KAK4042661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PPM4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17330">
        <property type="entry name" value="MFS_SLC46_TetA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF6">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08740)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="222"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="336"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="397"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="431"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="462"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="534"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="48"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="294"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4042661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="577" mass="63085" checksum="67977A1EC32F50E4" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PPR2</accession>
    <name>A0AAN6PPR2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_42634</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854317">
        <property type="protein sequence ID" value="KAK4044732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PPR2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05120">
        <property type="entry name" value="APH_ChoK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF58">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="41"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4044732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="258" mass="29813" checksum="2CEC9D5937257BC9" modified="2024-10-02" version="1">MGRLTTKEELAQATRFGPFCPVYLLADNKTIVKTGKTIRATEAHTMRFVREHTTMPVPEVYSVYEDEESGAVRIVMEYIQGTNLGHAWETLTEEEKESVVQQLRGYFDELRQIKGSFIGSVDGSACDDQFFSDDLWAYGPYKNEAEFNKGLVKAWTKDRDDPHTRLLVKTLLHVGQGHEIVMTHGDFAARNILVQGSKVVAILDWEFSGFYPEHWEFCKALWRTEWEAPWVKEGLLERVLDPYYPEVSLILNTSYKFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PPS3</accession>
    <name>A0AAN6PPS3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Up-regulated during septation-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_43945</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854332">
        <property type="protein sequence ID" value="KAK4043019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PPS3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029191">
        <property type="entry name" value="Uds1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15456">
        <property type="entry name" value="Uds1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Up-regulated during septation protein 1" evidence="3">
        <location>
            <begin position="399"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="122"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="279"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="544"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="479"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="172"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="224"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="256"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="286"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="544"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4043019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="707" mass="77024" checksum="5E50F0736840BB43" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PQ30</accession>
    <name>A0AAN6PQ30_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">chitinase</fullName>
            <ecNumber evidence="3">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">C8A01DRAFT_43056</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the glycosyl hydrolase 18 family. Chitinase class III subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="3"/>
    <dbReference type="EMBL" id="MU854321">
        <property type="protein sequence ID" value="KAK4044130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PQ30"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02877">
        <property type="entry name" value="GH18_hevamine_XipI_class_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045321">
        <property type="entry name" value="Cts1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050542">
        <property type="entry name" value="Glycosyl_Hydrlase18_Chitinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708">
        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708:SF49">
        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="5" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="10 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042855451" description="chitinase" evidence="15">
        <location>
            <begin position="23"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="17">
        <location>
            <begin position="30"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="16">
        <location>
            <begin position="400"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="146"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="364"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="365"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAK4044130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="436" mass="45330" checksum="23B8DF10955A68D6" modified="2024-10-02" version="1">MRGRARLAALCGLIATIPGVLAGFDPVASNNIAIYWGQNSINRAQGGQQRLATYCSNTSVNIIPLAFLTTIKNPTSVNFANAGDNCTTFSGTQLLRCPEIEQDILACQALNKSILLSLGGATYTEGGFASPSEATTWAATLWSMFGPPPPPPSNTTTTTTTTTTTNNSTTNSTATAAAPLRPFGAASVDGFDMDFEAPSANMAAFVSALRGHMDAAAATQTSGGEKTRKFLLSAAPQCPFPDAAMREMLEGVGFDFVSVQFYNNYCGAPGFVSGPGGPGNFNFGTWDEWARNGSVNKGVKVLVGLPGSTTAAGSGYVSGEQLKAVVQYARGFESFGGVMVWDMSQVYGNPGFLDSVVSALGGQLPGTTSTSTTASSTPSSTMMPTRTPTTTTSGTPPTGTLVPHWGQCGGREFLGSTQCEPPYTCVFVGDWWSHCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PQ61</accession>
    <name>A0AAN6PQ61_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_43088</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854321">
        <property type="protein sequence ID" value="KAK4044175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PQ61"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF2">
        <property type="entry name" value="SRPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="21"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="402"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4044175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="430" mass="47756" checksum="12B6EC69ECE2EE1B" modified="2024-10-02" version="1">MDPFVQEAFSLLGVGLFVIGLRLYVRISSAGFKHLHPDDYLMILAAVAYSVETYLAYSVGAFWKGLANNAMTDEHRRLLDPNSEEYHWRNLRVNGSKTQVAGWSTYTFLLWVIKAAMCTFYLRLTDGLGFETRIYAGFVLIVTTWIAVLLSILLGCLPFEKNWQIYPDPGNFCQPAISRIDIFVTVVLNAVTDLYLMCIPIPMLWTSSLRPLKKAGLMLLFSGGIFVTAAGILRCILIITDPVNGAQKAGSWAVRETFVAVITSNLPMISPLIARCFRPIIGSLRSMSSANKGSKLSQKGDTKLRGFVLEDKNPRRGMGPRSVNPIPNFSINASDEHIYIRHEEDGGTTSYDTDLESARATRGRGGVIVKQTSVEVIETRHSGDPAEERDVGDYYLVKQSQREAERLSRKPSVGGKRRRSSATFGVGRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PQ64</accession>
    <name>A0AAN6PQ64_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Kinesin-like protein KIP2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">C8A01DRAFT_44465</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Required for assembly of the mitotic spindle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854339">
        <property type="protein sequence ID" value="KAK4042580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PQ64"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000073">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF75">
        <property type="entry name" value="CENTROMERE-ASSOCIATED PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8 13" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="16">
        <location>
            <begin position="214"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="608"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="692"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="841"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="917"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="760"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="814"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="65"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="124"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="149"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="692"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="712"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="843"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="872"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="943"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="294"/>
            <end position="301"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00054086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00074598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAK4042580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1001" mass="107627" checksum="6E726F9647975C4F" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PQ93</accession>
    <name>A0AAN6PQ93_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Tubulin gamma chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">C8A01DRAFT_33288</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers. Gamma-tubulin is a key component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation. The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Spindle pole body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the tubulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854338">
        <property type="protein sequence ID" value="KAK4042625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PQ93"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02188">
        <property type="entry name" value="gamma_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000004">
        <property type="entry name" value="Tubulin gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000003">
        <property type="entry name" value="Tubulin gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000012">
        <property type="entry name" value="Tubulin gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002454">
        <property type="entry name" value="Gamma_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01164">
        <property type="entry name" value="GAMMATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="10">
        <location>
            <begin position="48"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="11">
        <location>
            <begin position="249"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK4042625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="462" mass="51638" checksum="82BCE7A2DBBEB003" modified="2024-10-02" version="1">MPREIITIQAGQCGNSIGSQFWQQLCQEHGISQDGNLEDFATEGGDRKDVFYYQSDDTRYIPRAILIDLEPRVIHGIQTGPYRNIYNPENFYVGKSGVGAGNNWGDGYQTGESVHEEIMEMIDREADGSDSLEGFMMLHSIAGGTGSGLGSFLLERLNDRFPKKIIQTYSVFPDTTNSGDVVVHPYNSMLTMRRLTQNADSVVVLDNGALSHIAADRLHLQEPSFQQTNQLVSTVMSASTTTLRYPGYMHNDLVSILASLIPTPRCHFLMTAYTPFTGDQVEQAKTVRKTTVLDVMRRLLQPKNRMVSTVPGKKSCYISILNVIQGEVDPTDVHKSLLRIRERRLATFIPWGPASIQVALTKRSPYIPMAHRVSGLMLANHTSIATLFKRIFRQYEGMRKRNAFLDGYKKTAPFSDGLSEFDESREVVADLIAEYEAAEDANYLNPDLGEQATSAETDKRMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2025-10-08" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PQE7</accession>
    <name>A0AAN6PQE7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rap-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_13370</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854332">
        <property type="protein sequence ID" value="KAK4043066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033596">
        <property type="term" value="C:TSC1-TSC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032007">
        <property type="term" value="P:negative regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051056">
        <property type="term" value="P:regulation of small GTPase mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11210:FF:000007">
        <property type="entry name" value="Tuberous sclerosis 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11210">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035974">
        <property type="entry name" value="Rap/Ran-GAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000331">
        <property type="entry name" value="Rap/Ran_GAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018515">
        <property type="entry name" value="Tuberin-type_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027107">
        <property type="entry name" value="Tuberin/Ral-act_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024584">
        <property type="entry name" value="Tuberin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10063">
        <property type="entry name" value="TUBERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10063:SF0">
        <property type="entry name" value="TUBERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11864">
        <property type="entry name" value="DUF3384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02145">
        <property type="entry name" value="Rap_GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03542">
        <property type="entry name" value="Tuberin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111347">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50085">
        <property type="entry name" value="RAPGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rap-GAP" evidence="3">
        <location>
            <begin position="1266"/>
            <end position="1496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="756"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4043066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1651" mass="181276" checksum="41D6844492C75906" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PRI1</accession>
    <name>A0AAN6PRI1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Vacuolar import and degradation protein 21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">C8A01DRAFT_43774</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EAF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854329">
        <property type="protein sequence ID" value="KAK4043285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014012">
        <property type="entry name" value="HSA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46459:SF1">
        <property type="entry name" value="E1A-BINDING PROTEIN P400"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46459">
        <property type="entry name" value="E1A-BINDING PROTEIN P400-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07529">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00573">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51204">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSA" evidence="11">
        <location>
            <begin position="655"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="10">
        <location>
            <begin position="920"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="111"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="233"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="363"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="414"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1015"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1281"/>
            <end position="1339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1473"/>
            <end position="1498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="136"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="242"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="256"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="294"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="307"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="551"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1294"/>
            <end position="1323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1324"/>
            <end position="1339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1473"/>
            <end position="1488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1489"/>
            <end position="1498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK4043285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1498" mass="161782" checksum="858B51BDA61F10D5" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SK89</accession>
    <name>A0AAN6SK89_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_21319</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854805">
        <property type="protein sequence ID" value="KAK4031451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SK89"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4031451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="326" mass="36639" checksum="13949A7600E4DD3C" modified="2024-10-02" version="1">MGDKLADTLATAFFVRVGRGFSLITCILRIELPSLQSIAFVSFWKPAELAELRELCDKNKHLLQTTPLGILALIYAQRVRGWEEWVASLWVDLNEIEVFLKMAPPGWESNRPTPQRVKELSNPDVLNRQFAAAHAQICLSQNILAFGVRYAEHCQEAMNTVEQARTGKRTRPGEREAFEACLRPSLSICKSLQDRSADLLERLRGLISMTANTIAQKEARTNRDIAQSSLRVAQSAASDSRMMKTIGLLGVLFLPATFTTALWEVNLFQLEEDTNKVAYAVTTVGLTLLVFGAWGSYMFLARKPFELYRGNESEVVRDAMELRPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SKG6</accession>
    <name>A0AAN6SKG6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_51319</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfotransferase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854725">
        <property type="protein sequence ID" value="KAK4031691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SKG6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11783">
        <property type="entry name" value="SULFOTRANSFERASE SULT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="3">
        <location>
            <begin position="63"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4031691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="317" mass="36972" checksum="E10C90FD857516F5" modified="2024-10-02" version="1">MAVLNEKRLHIGEYTDEMHAESPEDLRIGEHGYKYRLVEGRVMPPYITPARYALSRSVRTRASDICFVSYPKSGSTWLSYIIVLLTTTGADDPDPDRSGATTLRGSLHWVESSWTYPRSAEDLERAAAPRIFKSHMPYPMALGGEPAQNPCRYIYIARNPKDVCASYYYFESGKSWSGYYDGGWDHWLDMFLGGRVQRGDWFDHTLSWWEHRDAENVLFLRFEDLKLDTRGQLERIARFLGVRVSDDQLREVERKIGFAAMQQTEFSALREVKEFSRFFRKGEIGSWKEYFTAEQSEAFDRLYKERIGESGLEFMFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SKX1</accession>
    <name>A0AAN6SKX1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">N-acetyltransferase ycf52-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_42355</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU855117">
        <property type="protein sequence ID" value="KAK4031153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SKX1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF2">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="73"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4031153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="227" mass="24682" checksum="443D273888D4CE72" modified="2024-10-02" version="1" fragment="single">MIIRLASEADLEAMTAVLVGASPLDPVYPYRFPDRHLYPAEFAALCRRKCAEYLETSTVVVCELPIDVYGAATQVVAFSAWDMPAAAQPPRSRRASAVEPTSPTSPTLPTSPTTIGNLTRQSAFRAALTTHKIALFDARYRPEQGGHVFLKILLTHPSHQRRGAGTALALWGVEQARALGAYTTVFASPMGLSLYRRLGFREVGRFRVQLEGEGEFVEIPALALGPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SLK3</accession>
    <name>A0AAN6SLK3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_20135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854569">
        <property type="protein sequence ID" value="KAK4032861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SLK3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4032861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="118" mass="13537" checksum="38E3DDEE5C96984C" modified="2024-10-02" version="1" fragment="single">SSIDQWLEVVVSQVNNPEITNEDMELDVSKYVEVVKGLVENRIRAGRVEELGGQEVIGRFFSLLEVSRLAIIAESVLTTTRNFSRPWGNGRLSLQSKMELGSRIKYSRSRRYHFLYTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SLM3</accession>
    <name>A0AAN6SLM3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_20707</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854637">
        <property type="protein sequence ID" value="KAK4032189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SLM3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="343"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4032189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="387" mass="42539" checksum="6320761910504EB7" modified="2024-10-02" version="1">MNEGAAAESILDFLTAENPKIRHGDAKSASLTKVRNSFWPRQVKRWEGFSFASLKSAFGGRLIEEAQRKCSSLKYPTFLAGVDDFVYDEPTTTAVVTTWNHGIVKASLHAVQETLHPSTWVHSARDPQGKPASLTVSTTIRKRKAGAVQRLKPDAGAVSLCQNCAFQVERLPKDYKPANKWQSSSLSFEGATSTTGKWSSGEARRNEVRPIRQVYTYCVQFGCRYGCIITTREAFIFRIKPRIKASGAIPRGHGKMKALKKALATNGLMEYVSIPWEKPGPDGLTMNLALWFVHVLAGNGHAVDWDYEDLKSATLATETCPLGSATESSEVGPAFDELESLHSRSSSRSSSVSRKRGRSCDPGDEPNYSFAIVTDSFNTQVMSCVLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SLV6</accession>
    <name>A0AAN6SLV6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fungal-specific transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_51028</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854648">
        <property type="protein sequence ID" value="KAK4032112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SLV6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052073">
        <property type="entry name" value="Amide_Lactam_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47171">
        <property type="entry name" value="FARA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47171:SF3">
        <property type="entry name" value="FARA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="7">
        <location>
            <begin position="350"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="165"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="165"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4032112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="789" mass="88167" checksum="BE0DA2F90C25A3AA" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SMS8</accession>
    <name>A0AAN6SMS8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">DNA-directed RNA polymerase subunit beta</fullName>
            <ecNumber evidence="15">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">C8A01DRAFT_49402</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:21249"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="15"/>
    <dbReference type="EMBL" id="MU854492">
        <property type="protein sequence ID" value="KAK4034166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000011">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.150:FF:000004">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1070.20:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000008">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1070.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="entry name" value="DNA-directed RNA polymerase, subunit 2, domain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1800.10">
        <property type="entry name" value="RNA polymerase alpha subunit dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="entry name" value="RNA polymerase Rpb2, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009674">
        <property type="entry name" value="Rpa2_dom_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041640">
        <property type="entry name" value="Tyrosinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06883">
        <property type="entry name" value="RNA_pol_Rpa2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18132">
        <property type="entry name" value="Tyrosinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00497">
        <property type="entry name" value="TYROSINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 15 18" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 15" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12 15" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="16">
        <location>
            <begin position="1244"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="17">
        <location>
            <begin position="1449"/>
            <end position="1460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAK4034166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1762" mass="196089" checksum="F8CA92CC8821FB98" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SNT1</accession>
    <name>A0AAN6SNT1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_39477</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854497">
        <property type="protein sequence ID" value="KAK4034048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SNT1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4034048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="187" mass="19722" checksum="66BC0C3B579E0AED" modified="2024-10-02" version="1">MVRSTKAAGPTRLEPLAVDEGGHHDTSTAATAPLLPSAVDIDAIVERASRIAAKRVFRQLMVGLVLLIPELVAVALAGAATRELKRVKALPDETHVAVIVMIISVVAEVMWLCLALPILYCCSLPRGIMAISIGFLGAAAVGVSVYMFSVVGPHLRNGTCDGDKYEQECYRGLTKSIAAGCVRVLAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SNZ8</accession>
    <name>A0AAN6SNZ8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_17864</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854443">
        <property type="protein sequence ID" value="KAK4035441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SNZ8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF16">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="77"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4035441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="137" mass="15218" checksum="81866B179C181C57" modified="2024-10-02" version="1" fragment="single">MQQFLTVSDLPAPYSHFTPVPVVSKHSDSPQCFDQIGQWIAQCEAGHEDCKAPNAVRLPTRVVDLNPTSDGSLEPSALSYVWGDTLPQRLTRAVLESFKSGIPWSDIPKTLQDAMTITHLLGLRYLWVDALTIIQDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SP94</accession>
    <name>A0AAN6SP94_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7907 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_18669</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854475">
        <property type="protein sequence ID" value="KAK4034558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SP94"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057229">
        <property type="entry name" value="DUF7907"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25484">
        <property type="entry name" value="DUF7907"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042813828" description="DUF7907 domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7907" evidence="2">
        <location>
            <begin position="30"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4034558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="205" mass="21245" checksum="5F2F884E4ACCC2A7" modified="2024-10-02" version="1">MRFTISTLTLAAAATALPSQHARTTTTSTSKGFNLVAHVTDATSDLTPSVEGLFLSTAHTGAGLNAAVLSAANGRLFYQNGTTAEDSDILTDGGTPLFPFSLQVQPAGEARRILDISVGQGTAGSVDAQGRLVNGLGAGAFLACRQVVPYYNQEFITLQYVYGDADPAGLEGCATIELVAKCAELNELPEGSLSSHEFAAEVKCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SPC0</accession>
    <name>A0AAN6SPC0_9PEZI</name>
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        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_38403</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854454">
        <property type="protein sequence ID" value="KAK4035129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SPC0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36460">
        <property type="entry name" value="UPF0132 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_3G10255)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36460:SF1">
        <property type="entry name" value="UPF0132 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_3G10255)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
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            <end position="171"/>
        </location>
    </feature>
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            <end position="201"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
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            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
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        </location>
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        </location>
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        <location>
            <begin position="85"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4035129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="250" mass="26795" checksum="0B1EEBCDE21B3D26" modified="2024-10-02" version="1">MDFAPYQSSPPEHTRSPTHSAAASPRTSLENNNNNNGHNRRGAYSPSTGHHYQHRQSQFSPPPLQHPQPQRAWSGEGVGRYQSPAAAAAAAAAGHSTTTATGGGSPWGNHGVSGSSGGGGGGGMGDYFSALGAREGMVSEFDTSLGLRLDYEACLAYLAVPPLGGILLLILERKSDYVRFHAWQSSLLFTALFVVHLLFSWSTFLSWVIFLADLGLIAWLVLNAYRDADTLDRYEVPIVGPIASRILDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SPL8</accession>
    <name>A0AAN6SPL8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_37633</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854430">
        <property type="protein sequence ID" value="KAK4038389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SPL8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042988498" evidence="3">
        <location>
            <begin position="22"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="240"/>
        </location>
    </feature>
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        </location>
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        </location>
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    </feature>
    <feature type="non-terminal residue" evidence="4">
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            <position position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4038389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="309" mass="31060" checksum="A4BCFD56F7ABAF2D" modified="2024-10-02" version="1" fragment="single">MAVMSLRWLVAAAASLPAVSAGLGREQLSPGGPVQTPAPQLKDAALHMQFSPVVTARPAARGLLQKRATNTCGYLNGDASSEYVCSHSEAQCLYNSDASAMGCCLTTSCAIYTACLPFASSAATKTFDKERTRYCSNSDLPSCAVFSYADASGSLAGYTIPTCDSVSTTYTMYLLPRTASSSSRRTSSSKSSSKSSSESSGSSSSSSSPTGQDSGGNPAPAETSADAGAEAAPASSSTPVGPIVGGVVGGLAGLGLLGLGIFFLVRRNKNPTSPSANAAAPVLTGGPAFMPPPGSSGSQGQQSPYPPTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SPR1</accession>
    <name>A0AAN6SPR1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_18217</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854456">
        <property type="protein sequence ID" value="KAK4035083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SPR1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="440"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="524"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="676"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="621"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="64"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="129"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="152"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="166"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="224"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="561"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="715"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="748"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="781"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="792"/>
            <end position="801"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4035083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="831" mass="87386" checksum="07EFC6BF33350101" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SQH7</accession>
    <name>A0AAN6SQH7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_37520</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854426">
        <property type="protein sequence ID" value="KAK4038540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SQH7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF814">
        <property type="entry name" value="NAD-DEPENDENT EPIMERASE_DEHYDRATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="5"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4038540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="341" mass="37425" checksum="36C4600971594C5D" modified="2024-10-02" version="1">MPATLLTGANSFVGAHVINSLIAAGHAVIGTVRRENLIDQIYALHPEWKESLELIVVKDYAEESSWDEVFSKYSLDHIVHVAAPLLDNPANTDYTRDYLKPTVDGNLALLRSAHRNASTIKSIAVTGSVNALTTGMPEELLAGPITNKTWLPISQEQAREMNNAYISYCSAKKEGELVIWDFVKTEKPSFAVTVLLPALIFGPPLQPLKGVKNLNYSTNVIYEFINGKHETIPATTFPSFVDVRDLADAHVKVLTQPEAANRRLLINGKPMTYTMLVHALAKVPELAGRLPADSGEDAKVTPAEIDAEADNKLLGLTFRTVEETMADTARRLLELERAESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SQL6</accession>
    <name>A0AAN6SQL6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_37427</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854423">
        <property type="protein sequence ID" value="KAK4038660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SQL6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050501">
        <property type="term" value="F:hyaluronan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0085029">
        <property type="term" value="P:extracellular matrix assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030213">
        <property type="term" value="P:hyaluronan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22913">
        <property type="entry name" value="HYALURONAN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22913:SF12">
        <property type="entry name" value="MANNURONAN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13641">
        <property type="entry name" value="Glyco_tranf_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="497"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="553"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="580"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4038660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="601" mass="66854" checksum="B68BAD2BB22E2B1F" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SQY4</accession>
    <name>A0AAN6SQY4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">lytic cellulose monooxygenase (C4-dehydrogenating)</fullName>
            <ecNumber evidence="15">1.14.99.56</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">C8A01DRAFT_17055</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the polysaccharide monooxygenase AA9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="15"/>
    <dbReference type="EMBL" id="MU854416">
        <property type="protein sequence ID" value="KAK4038886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SQY4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF10">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043029971" description="lytic cellulose monooxygenase (C4-dehydrogenating)" evidence="16">
        <location>
            <begin position="17"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="17">
        <location>
            <begin position="17"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAK4038886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="230" mass="24508" checksum="2C67498C4076280E" modified="2024-10-02" version="1">MQLLTGLLLAATAVQAHYTFPRLVVNGKSEEKDWSATRMTKNAQSKQGVESATSGDIRCYTSQTAANVATVPAGSTIHYISTQQINHPGPTQYYLAKVPAGSSAKTFDGSGAVWFKIATTMPTVDNNKQLVWPGQNAYTTTNTTIPASTPNGEYLLRVEQIALHMASQPNKAQFYIACSQIEITGGGNGTPGPLVALPGAYKTNDPGILVNLYSMQPNEYKPPGPAVWSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SRL2</accession>
    <name>A0AAN6SRL2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Copper-containing nitrite reductase</fullName>
            <ecNumber evidence="4">1.7.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">C8A01DRAFT_16570</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>nitric oxide + Fe(III)-[cytochrome c] + H2O = Fe(II)-[cytochrome c] + nitrite + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:15233"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16301"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.7.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Cu(+)</name>
            <dbReference type="ChEBI" id="CHEBI:49552"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.7.2.1" evidence="4"/>
    <dbReference type="EMBL" id="MU854400">
        <property type="protein sequence ID" value="KAK4039458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SRL2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050421">
        <property type="term" value="F:nitrite reductase (NO-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd11020">
        <property type="entry name" value="CuRO_1_CuNIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04208">
        <property type="entry name" value="CuRO_2_CuNIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000093">
        <property type="entry name" value="Copper-containing nitrite reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001287">
        <property type="entry name" value="NO2-reductase_Cu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF394">
        <property type="entry name" value="FI03373P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00695">
        <property type="entry name" value="CUNO2RDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0186">Copper</keyword>
    <keyword evidence="6 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Plastocyanin-like" evidence="14">
        <location>
            <begin position="155"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="13">
        <location>
            <begin position="324"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="71"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="71"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="binding site" description="type 1 copper site" evidence="11">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="type 1 copper site" evidence="11">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="type 1 copper site" evidence="11">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="type 1 copper site" evidence="11">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="type 1 copper site" evidence="11">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="type 1 copper site" evidence="11">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="type 1 copper site" evidence="11">
        <location>
            <position position="405"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601287-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK4039458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="445" mass="48470" checksum="06F7C5BBE3FAD484" modified="2024-10-02" version="1">MFHSAAQITLSQQARRLLQVPNGRRALSSKTNHHTTQRQRVAVQVVSASALGALFLLYPRRPARLDLLPDRTAPKHESEPAERPVFVSPGLKDQDAKSDSRLQFYETLDVESAVDLPSEDAILTQAPYVPPAITRDYPVLLHVPLTTSAKLAQLTNQYQYEQWTFNGTVPGPFIRARVGDVVDLTLTNRDDAGNPHNIDCHAFTGPGGGAALTTAEEGETKSARFKLLHPGLYLYHCAAAPVPVHIANGMYGLMYVQPASDTDGEGGDLPPVDREYYVMQSEFYHEPPEILDDGRPSRVVEFSYPEGLREEPSIVVFNGSESALTRDRPLKATAGETVRIFFGNAGPNLTSSFHVIGSNFKNVYREGDVLSPPGRFVSTVSVPPGGATIVDMKMVVPGTYTLLDHAIFRLDKGAVGFLNVSGKPRPDVYGSSEPPAPCVGCKLHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SRY6</accession>
    <name>A0AAN6SRY6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_35881</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the secreted LysM effector family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854384">
        <property type="protein sequence ID" value="KAK4040100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SRY6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052210">
        <property type="entry name" value="LysM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997">
        <property type="entry name" value="AM15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997:SF2">
        <property type="entry name" value="LYSM DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042948771" description="LysM domain-containing protein" evidence="6">
        <location>
            <begin position="23"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="7">
        <location>
            <begin position="156"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="7">
        <location>
            <begin position="238"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="7">
        <location>
            <begin position="317"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="7">
        <location>
            <begin position="394"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="105"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="105"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4040100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="443" mass="45968" checksum="73785D0F11EF4F91" modified="2024-10-02" version="1">MLASASLSLLVGATSLFNVALGAAVGRVGARDGTEPSLTADPNTTTWCTWWADLTVAKSCSKLLSDNEITLEQFRRWNPSIPETCGTLAAGHSYCVEALFEPVPSTTSTSTTARITSSSTSTTPPISTPPATTTTPGNGVATPGPIQSGMVGNCNKFHWVEKDQNCAIIAALYSISAAQFSQWNPAAKSDCSGLWASTYACVGIIGGSTPVPSTTLPANGIATPTPTHPGMMASNCNKFTKVNPGDTCDVISFFNGPIATEDFVVWNTGVGGRDCRTLQAGTYVCVGLIPGGTPTNPGNGIATPQPTHPGMVSNCNKFVKVNSGDSCDAIAFWNGVAGTEWVIKWNTGVGSDCRTLQADTYACIGVIGGTPTSPGNGIATPTPTQPGMVDYCKKFTKVNQGDTCDIISFFNGPISTADFIKWNPGVGQDCRGLQLGTYVCIGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SSE0</accession>
    <name>A0AAN6SSE0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CorA-like transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_35128</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854368">
        <property type="protein sequence ID" value="KAK4040852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SSE0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058257">
        <property type="entry name" value="CorA-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26616">
        <property type="entry name" value="CorA-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="609"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="651"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="domain" description="CorA-like transporter" evidence="3">
        <location>
            <begin position="147"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="CorA-like transporter" evidence="3">
        <location>
            <begin position="354"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="675"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="743"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="744"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="757"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="787"/>
            <end position="808"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4040852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="808" mass="90400" checksum="927C38299C077940" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SSG0</accession>
    <name>A0AAN6SSG0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA-directed RNA polymerase III subunit RPC6</fullName>
            <shortName evidence="6">RNA polymerase III subunit C6</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_14805</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854357">
        <property type="protein sequence ID" value="KAK4041419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SSG0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000116">
        <property type="entry name" value="DNA-directed RNA polymerase III subunit RPC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007832">
        <property type="entry name" value="RNA_pol_Rpc34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016049">
        <property type="entry name" value="RNA_pol_Rpc34-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12780">
        <property type="entry name" value="RNA POLYMERASE III DNA DIRECTED , 39KD SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05158">
        <property type="entry name" value="RNA_pol_Rpc34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028763">
        <property type="entry name" value="RNA_pol_Rpc34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="201"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="207"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR028763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4041419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="410" mass="44933" checksum="7785F7F0173F6BA8" modified="2024-10-02" version="1">MASDSVGLDSVKSQILKDALYEEIKQHGSETRLFTQKDLIDLNIIPNNDVKQLLDIVQQLCNDKLLVGTTNHHAGLSWRWRSREEAKKYTSLPNDEAVMVYSIIDEAGADGIWNRTIKNKLNMHENVVKTCIKFLETKGYIASMKNVEHPNKKMYIKATLRPSERATGGPWFTEGELDTAFIAELEGIVFEYIKTKSAYRGSQPHTGGAASSSAGATKLPKKGAVTAADTTARGTKRSATEISTDDAAARAGGKSRAVFLPMPAGYKHYPTVAEIAKFIHDTGITNNTTLGEADIQQLVDVLTYDGLIEMVRVGRRRGYRVARAVKQDTVPFHKRQKEREAGVGLDLLPLIPGAEPLGNGLTEAPCGRCPVFELCEEGGPVSPSNCVYFLQWLELEDLPKAVAPSVPLPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6ST33</accession>
    <name>A0AAN6ST33_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Phosphatidylinositol N-acetylglucosaminyltransferase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_44792</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854345">
        <property type="protein sequence ID" value="KAK4042139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6ST33"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000506">
        <property type="term" value="C:glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009450">
        <property type="entry name" value="Plno_GlcNAc_GPI2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12982">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN, CLASS C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12982:SF0">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06432">
        <property type="entry name" value="GPI2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="303"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="333"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="425"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="456"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="210"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="257"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="74"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="210"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="257"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4042139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="507" mass="55538" checksum="9EBED0900A460CEB" modified="2024-10-02" version="1">MAPPSGLHQSAIPSDFETPFPPLMRSSTVPALTSHRADPSHLAPEDAYSSFSPPRRSGDFDSRGNGSGTDSRPGRIRHKDASRSRSRRRKRFQKLLWVKQSYPDNYTDQATFLENLQRNPRVRPYDFWPLVADSTVIVQHVCSVIIFVVCFVGIFQERSQGGSADEDARARMIRDGRAYREYRPPRRQDSLGLEQSSMLNASTVSISSASNLPSAASSTSNLLQDHHQPQRPFHPLGSSTGNSGLLVPAHAHSRSVSSVNSMASQASAANSPTTTRLGPDGPHHGPTGSPTARNSRVYVRLSTIKSAILIYFTLLGLSPILKSLTRSTSSDSIWAMSFWLLAINVFFFDYSGSAAAATATTGTTHSKQMPVASLSTNAALMASTVLASRLPSTGQVFSLTLFSIEVFGLFPVFRQYARHRSWRYHVVLTVLLVLGAGAGVGMILGDERGWPWKKGLLGMVVGCLIAALALGGCSWWLIGLQKYKNEIYGPWDPARPIIISRRHWDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2025-10-08" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6STD3</accession>
    <name>A0AAN6STD3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PhoD-like phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_34427</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854355">
        <property type="protein sequence ID" value="KAK4041585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07389">
        <property type="entry name" value="MPP_PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.70">
        <property type="entry name" value="PhoD-like phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018946">
        <property type="entry name" value="PhoD-like_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038607">
        <property type="entry name" value="PhoD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043904">
        <property type="entry name" value="PhoD_2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46689">
        <property type="entry name" value="MEMBRANE PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46689:SF1">
        <property type="entry name" value="PHOD-LIKE PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19050">
        <property type="entry name" value="PhoD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PhoD-like phosphatase" evidence="2">
        <location>
            <begin position="877"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="domain" description="PhoD-like phosphatase" evidence="2">
        <location>
            <begin position="1140"/>
            <end position="1299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="449"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="779"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1302"/>
            <end position="1585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="300"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="779"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1440"/>
            <end position="1456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1457"/>
            <end position="1469"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4041585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1585" mass="174549" checksum="D07D4A9EACF67396" modified="2024-10-02" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SUH3</accession>
    <name>A0AAN6SUH3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GDP/GTP exchange factor Sec2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_43952</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854332">
        <property type="protein sequence ID" value="KAK4043027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SUH3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070319">
        <property type="term" value="C:Golgi to plasma membrane transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040351">
        <property type="entry name" value="RAB3IL/RAB3IP/Sec2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009449">
        <property type="entry name" value="Sec2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14430:SF4">
        <property type="entry name" value="GDP_GTP EXCHANGE FACTOR SEC2 N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14430">
        <property type="entry name" value="RABIN3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06428">
        <property type="entry name" value="Sec2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144284">
        <property type="entry name" value="Sec2 N-terminal region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GDP/GTP exchange factor Sec2 N-terminal" evidence="4">
        <location>
            <begin position="157"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="80"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="35"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="163"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="88"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="103"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="251"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4043027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="267" mass="28293" checksum="5D417E9110999000" modified="2024-10-02" version="1">MAVASAGTLTTARAPPQTQTPCCPNCGFGADLPPFEETQTALLTAQKQISDLQAQVRLLNQKASAAVDRWADYEDELAKLRSQLDSRPQTPSSTTTTTTNPQTPAPPQKPPPPPPPPPPPSLPSSASYPPPPTSSGGGGIPISPAPSLPTSAQLTPEDLLTALSREQALRQQAEGRLTQTSREVEELSASLFEQANEMVATERRARARLEERVGELEKREGDKRRRLERLERAVGRIERVRGVLGEMEGLSGVGGVGGGGVKGGSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SUK6</accession>
    <name>A0AAN6SUK6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Tethering factor for nuclear proteasome STS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">C8A01DRAFT_44303</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">Involved in ubiquitin-mediated protein degradation. Regulatory factor in the ubiquitin/proteasome pathway that controls the turnover of proteasome substrates. Targets proteasomes to the nucleus and facilitates the degradation of nuclear proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 9">Binds the proteasome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the cut8/STS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854337">
        <property type="protein sequence ID" value="KAK4042681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SUK6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071630">
        <property type="term" value="P:nuclear protein quality control by the ubiquitin-proteasome system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031144">
        <property type="term" value="P:proteasome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1590:FF:000001">
        <property type="entry name" value="Tethering factor for nuclear proteasome STS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1590">
        <property type="entry name" value="Tethering factor for nuclear proteasome Cut8/Sts1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013868">
        <property type="entry name" value="Cut8/Sts1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038422">
        <property type="entry name" value="Cut8/Sts1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28032">
        <property type="entry name" value="FI02826P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28032:SF1">
        <property type="entry name" value="FI02826P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08559">
        <property type="entry name" value="Cut8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="47"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK4042681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="304" mass="33087" checksum="32F6223A4D85708E" modified="2024-10-02" version="1">MNVLLSPQPPTFPLQCDPSRLPPPLPAPQYTMASRKRKADDDNDEMSLSPLSSPATSSRQLARPLKKVRGASDMAGRPLALPRLLETLDNTQLRTVLQTICERHPDIGREVVTGAPRPSVASALQVLGDYQDKLRAAVPFGQSSSDYTYFRVKQPLAALVDAMSDFTPQFLPPVEQQTNISLQYLDAATKIIHELPDWESQQYRHHKDNAYDEISGAWALVITEAAKRGGGFVLHTGGWDQRLAKHNQQSGGKLEQAMGAMATEVPWAGSSSTAAPASGLSDPNSILNQLINGTYGSPVRVGPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SUT8</accession>
    <name>A0AAN6SUT8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_43725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854328">
        <property type="protein sequence ID" value="KAK4043417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SUT8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="251"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4043417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="322" mass="34595" checksum="3FF58C1D98B5183B" modified="2024-10-02" version="1">MAATHSPDYSDDEFDFDEEYFSRTYQPLSNLPTPPPSSRESLAGQSPRALLEDGGLLDSALLGPAVHLVNLIPPAASLSAPSVPLVHEMLVRADLPMDTIALAVCILDSLSSKFSLNWRLLCPLAQHEPTNGITKRHTIQASPKGATQLHIDSVNPEVIVLSALIIAFKFLVDCQEPTHYYRAAWGSNTWTCDQINVTERCIMENLGYRILPLWHPALIADAVGDMQRAARQAALLPPLPRNGEPPHKRSASSADALSSSHTFPLTPVETPVSEDGPTVVVNPLREAMGDDAFGGGGPSPVDASMLHLPPRTKRKAGSTAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SV20</accession>
    <name>A0AAN6SV20_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Histidine phosphatase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_13331</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854331">
        <property type="protein sequence ID" value="KAK4043103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SV20"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF54">
        <property type="entry name" value="PHOSPHATASE SPAC5H10.03-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4043103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="268" mass="29428" checksum="C681DE523C95C988" modified="2024-10-02" version="1">MPTYIHLVRHAQGFHNLSHANHALPDPDLTPLGKDQCAHLARTFPFQSQLTHLVASPLRRTIYTCLLSFEPALQQQQQGSTKKVVVALPELQEVSPLPCDTGAAPEALASEFGPGGQVDLGLVAPGWNVKTGDSPFAPVMARLEARARKARVWLREVGREFERVNPGVDAHVAVVTHGGILHFLTQDWDGMNPEAGTGWANTEWRSYEFVDGLEGDTDGEARLRETGGSWRRRRGSATGLTETEQMELRVAVEGQLVEEWGVDGGKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SV33</accession>
    <name>A0AAN6SV33_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Ribose-phosphate pyrophosphokinase 1</fullName>
            <ecNumber evidence="4">2.7.6.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Phosphoribosyl pyrophosphate synthase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">C8A01DRAFT_32481</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15609"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ribose-phosphate pyrophosphokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.1" evidence="4"/>
    <dbReference type="EMBL" id="MU854328">
        <property type="protein sequence ID" value="KAK4043355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SV33"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002189">
        <property type="term" value="C:ribose phosphate diphosphokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009156">
        <property type="term" value="P:ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000017">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000043">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000842">
        <property type="entry name" value="PRib_PP_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210:SF57">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01400">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00114">
        <property type="entry name" value="PRPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="19" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribose-phosphate pyrophosphokinase N-terminal" evidence="18">
        <location>
            <begin position="5"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="226"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="226"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="267"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00040334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00077829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAK4043355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="506" mass="54781" checksum="029AA784435E4443" modified="2024-10-02" version="1">MRGTLIFAGSSCPDITDKICQNLGMARADAELTQFSNGETSVRILTSVREKDVFVVQSGSPKINDTIMELLIMISACKGGSANKITAVLPYFPYSRQSKKKSHRGAITARMLANLLGVAGVKHVVTVDLHASQMQGFFRCPVDNLHAEPLIARWIRRNVPRWQEAVVVSKNAGGTKRVTSLADALKLNFGMVTTDKKRGPGPSMAGSMISYPLDGIERQPVLDPISNQVRNNSSEPENGTPATDSGRSQDSRTAADAQGSPRMRANGTHSRNPANRKSPPRRSQTTLSQSSVIDELDEEAEADGLEYNDQRAHEVTHGRLVQGHIVPDDFPSPAASVADTNVPEDDPMTLSHASSFFAPQPHALGGSGDVGASSDEEDDILKDPKVERTITLVGDVKGRAVFIVDDMIDKPGSWIAAAETVVKRGRASKVYCIATHGVFGGDCLEQMQACDCIDTIVVTNSYPIPEHKARNASKLVVLDLSFLLAEAIRRNHYGESMSPLFQHLMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SVJ9</accession>
    <name>A0AAN6SVJ9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_32186</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854325">
        <property type="protein sequence ID" value="KAK4043658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SVJ9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4043658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="403" mass="46979" checksum="6EC60ECE581C0D9C" modified="2024-10-02" version="1">MLHSERGYKALADIGVDVWPKWYEGDTISHDDMCKNIDIFLERLDRNFIEITLTKDHPFNGSYMCVDWYKPDEGMDSWDPRTGGIMTLNHFMVESMAKARDGTSTNHQDASLVFYFHLGLTIVHELVHCFMNFLSGDEENDTPTEIVDIQFTKGSSNRPWGDSDRPSSTSRGVFLIISREPSLGPGWLSIHEDWLSFHEDWLSFHEDWLPFYEGWFPSRFVSRRASYACVCYAPDRPSSTSRRVFIIVSREAFPREGWLPFHQGWFRSLFVSRRASHARICYPPDRPSSTSHRAFGISRQALPSAGWFLFHKGWLPFHEGWSPSRFVSRRASHACVCYAPDRFSSTPRRVFLIISREDSPGEEWLSFHEGWHPFCEGWCPFCKCRFPSCGVFKFRRKFCPYPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SVN3</accession>
    <name>A0AAN6SVN3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Pre-mRNA-processing protein 45</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_42412</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the SNW family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854316">
        <property type="protein sequence ID" value="KAK4044794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SVN3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017862">
        <property type="entry name" value="SKI-int_prot_SKIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004015">
        <property type="entry name" value="SKI-int_prot_SKIP_SNW-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12096">
        <property type="entry name" value="NUCLEAR PROTEIN SKIP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02731">
        <property type="entry name" value="SKIP_SNW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043310846" description="Pre-mRNA-processing protein 45" evidence="6">
        <location>
            <begin position="22"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="7">
        <location>
            <begin position="32"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="326"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="368"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="447"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="600"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="379"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="453"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="489"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="502"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="638"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="667"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="687"/>
            <end position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4044794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="701" mass="78369" checksum="04B24C15112ACF29" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SW97</accession>
    <name>A0AAN6SW97_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_42861</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854319">
        <property type="protein sequence ID" value="KAK4044436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SW97"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4044436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="401" mass="44158" checksum="4D5E4651E8A11173" modified="2024-10-02" version="1">MAHQPLERSLPILVRPSDGQDSQSSMGVNVSEHSMGSDSVLRLPPSRSSSLREPPMYNTGCQSPPATPPLDPGPETENPLIGGIGCHFPATLPSRAAFLTMESESATDSPTTPRAEPEGLDPDDLSAIEADLDTPRADAYSFETPIWPARLGESIFGAVLPLTPGLTPMRKRAASPPFAPRPAKRLKMHTQSAYESSRDEAYPDEDSHGLASGPAFRIAEQLTIDLMEATGFPVDNGSPEDDIFRQVETLRHTGPCSPCDDNSPVSETARTERRATQRRYAVDIESFTEDEIEEHLAGLLSAYRAFYLEPDGAEPPQPRDPEKARASRRIFRAIFDPQLGSAGDEEFLWQEEEEDVLDTFMAWTREKRIPSGLHRETFEDLSECLEHVGNLANAPFVKHIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P3L8</accession>
    <name>A0AAN6P3L8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_21612</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU855239">
        <property type="protein sequence ID" value="KAK4028545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P3L8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4028545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="56" mass="6198" checksum="7F6FDAC24FB5BECA" modified="2024-10-02" version="1" fragment="single">WIQIIMAGVSKQVIRLSYLLYYASSFGYIGLVDTIIRFDDIVDLEAPGSRTGSTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P4I6</accession>
    <name>A0AAN6P4I6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Lactose permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_21195</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854745">
        <property type="protein sequence ID" value="KAK4031624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P4I6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000217">
        <property type="entry name" value="MFS lactose permease, putative"/>
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    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF70">
        <property type="entry name" value="MONOSACCHARIDE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G14540)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="300"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="367"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <begin position="397"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="439"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="463"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="50"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4031624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="534" mass="58957" checksum="EB25E08B8E7E6D07" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P5Y8</accession>
    <name>A0AAN6P5Y8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Dynamitin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_50807</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854615">
        <property type="protein sequence ID" value="KAK4032389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P5Y8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028133">
        <property type="entry name" value="Dynamitin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15346">
        <property type="entry name" value="DYNACTIN SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04912">
        <property type="entry name" value="Dynamitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
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            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="294"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="364"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
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            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="305"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4032389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="428" mass="46665" checksum="700D76457BF79681" modified="2024-10-02" version="1">MASNRKYAALPDLDSAPDIYETPELTDDHSTVPPTTVRSPSDNEYDDDEDDATGISRSRLRINQARSRFMPAAVDAADVDFSDRLASKRKSYKTSTRRHRILEDGTEEIGDLSDEDDTRNLARKIARLKREIEEAKEEYGKQKAASSESKDEEEVAEGEFESLSKVLDEMSGLGQTLAPRAIPAPPPAGLGEKAPGEHADSVSYTITYAPSYEQTHALAKAADFDSRLVVLEKALGVGSAAMPEFDSNGLPRAIVPLLEYLHKQVSTLSEASVPSLDSISRRVRALTQEAENLEKARRNAKTAHDALASAGAAPTAEAATPEDSEQTAKINALYGTLPTIESLTPLLPPLLDRLRSLRIIHADAATASETLARLEKQQAEMAGEIQQWREGLEKVEGAVRAGDATMAKNVDVISRWVKDLEEKMSKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P605</accession>
    <name>A0AAN6P605_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_20509</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854612">
        <property type="protein sequence ID" value="KAK4032419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P605"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="471"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="527"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="471"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="537"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="578"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="604"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4032419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="622" mass="65979" checksum="84C73E6A559E7B9C" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P6X9</accession>
    <name>A0AAN6P6X9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Rad4 transglutaminase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_40665</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854567">
        <property type="protein sequence ID" value="KAK4032884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P6X9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:nucleotide-excision repair factor 2 complex"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:XPC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:damaged DNA binding"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="DNA repair protein Rad4 family"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rad4, beta-hairpin domain BHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2460">
        <property type="entry name" value="Rad4, beta-hairpin domain BHD3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Transglutaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BHD_2"/>
    </dbReference>
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        <property type="entry name" value="DNA_repair_Rad4"/>
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        <property type="entry name" value="Papain-like_cys_pep_sf"/>
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        <property type="entry name" value="Rad4/PNGase_transGLS-fold"/>
    </dbReference>
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        <property type="entry name" value="Rad4_beta-hairpin_dom1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR036985">
        <property type="entry name" value="Transglutaminase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12135:SF2">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12135">
        <property type="entry name" value="DNA REPAIR PROTEIN XP-C / RAD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10403">
        <property type="entry name" value="BHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10404">
        <property type="entry name" value="BHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10405">
        <property type="entry name" value="BHD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03835">
        <property type="entry name" value="Rad4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01030">
        <property type="entry name" value="BHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01031">
        <property type="entry name" value="BHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01032">
        <property type="entry name" value="BHD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="7">
        <location>
            <begin position="608"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="8">
        <location>
            <begin position="667"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="9">
        <location>
            <begin position="737"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
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            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
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            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="582"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="864"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="98"/>
            <end position="118"/>
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            <begin position="119"/>
            <end position="129"/>
        </location>
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        <location>
            <begin position="220"/>
            <end position="246"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="380"/>
            <end position="392"/>
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            <end position="408"/>
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        <location>
            <begin position="427"/>
            <end position="442"/>
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        <location>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4032884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="993" mass="111387" checksum="E4384EF8DC63ABDE" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P746</accession>
    <name>A0AAN6P746_9PEZI</name>
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        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_50445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4032860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="310" mass="34427" checksum="22AFDE7D218D2F7B" modified="2024-10-02" version="1">MVGLLRLPNELLAIIFGGLDAQGFSALRLSSKSAKVATLLAFISRYFQTRYIMLLRLSLENLVEIARHLDFGPAVRTLELCTDHFVEFPDLGSHLVRHKGDIVLAIQEGRYPPAALGTDEGNKVAYITQALISLTNIEAIEVPFLGRVLRITLTAIATSGTALSSLAITASVLSRAGVLSREAIAPDILRPSESHFQYYKNLPPSLTELILNVSARATRGAEDRWTDDLLAFIGVNRLKQLVPKLQLLNLQYLGFYRRSLFALIRYYLPRLELSIKLYTVGGLTLEFEDCFNVGGGHEAWTKAIELIETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P771</accession>
    <name>A0AAN6P771_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_41469</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854650">
        <property type="protein sequence ID" value="KAK4032092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="128"/>
        </location>
    </feature>
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        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4032092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="166" mass="19218" checksum="7D34D97A5751781D" modified="2024-10-02" version="1">MTVGIYSVTMSPVLNVVLFGTAESGAPFHFQAVLKLYDRRFGTSLQRHRYQHVPHTAEREADFQAFVRQGRMDYFLKKQEEEEEEEDEEEEEEGEEQDEDNVKPQSPLDPQPQHFPKEPPNPEPTAKFEAALWKECQDNFTGETEAYNRLQDLQGKSISPTHPATY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P7D7</accession>
    <name>A0AAN6P7D7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transglutaminase-like superfamily-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_40534</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854558">
        <property type="protein sequence ID" value="KAK4033010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P7D7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.390">
        <property type="entry name" value="Hemimethylated DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011722">
        <property type="entry name" value="Hemimethylated_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036623">
        <property type="entry name" value="Hemimethylated_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032698">
        <property type="entry name" value="SirB1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31350:SF27">
        <property type="entry name" value="HEMIMETHYLATED DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31350">
        <property type="entry name" value="SI:DKEY-261L7.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13369">
        <property type="entry name" value="Transglut_core2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08755">
        <property type="entry name" value="YccV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00992">
        <property type="entry name" value="YccV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141255">
        <property type="entry name" value="YccV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="2"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4033010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="624" mass="71697" checksum="711C894CC892F80A" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P8W5</accession>
    <name>A0AAN6P8W5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_39614</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854503">
        <property type="protein sequence ID" value="KAK4033918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P8W5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050665">
        <property type="entry name" value="Cytochrome_P450_Monooxygen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24282">
        <property type="entry name" value="CYTOCHROME P450 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24282:SF211">
        <property type="entry name" value="CYTOCHROME P450-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4033918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="432" mass="47643" checksum="0CCC88080155DD7F" modified="2024-10-02" version="1">MLALAGSVCLLPLLLFLFWEWRAWRVQGTRQRAGCADGAGLQEWVREQRNVAGFRFAGRLGLLERLRLRATENGRLRAAFKIDNSLTTASLSVHKDFLQKASWLLRRENRSWDELYSMAQAFLKAEVETAVKKGQHNLRLAESVRCMVLAVVLFDSFGVNPASIPRADLVTITNEINKQWLRSKRQPTDATSSQLLNSAIASLNITSPFPGADHAVLSPAEILGLLMPQYETLWRVVLLTFLTAYHHQPDAHPDAAQRAADVPACLGDPNREKEALKLAKEGLRLYPSNKHLYRSSLNPTPPNTPPVVAADISALHRHPYIWGGDALAFRPSRFDKGVMTDLQREAYIPFSVAPHKCPAAGNAFGERMVAVLVVALGRGWGPERGRVVFGGGGGGGGEELPTGRDEMEEWVWESDFGGRGLLVDLGCLRLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P900</accession>
    <name>A0AAN6P900_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PRELI-like family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_49541</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854501">
        <property type="protein sequence ID" value="KAK4033963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P900"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006797">
        <property type="entry name" value="PRELI/MSF1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037365">
        <property type="entry name" value="Slowmo/Ups"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11158">
        <property type="entry name" value="MSF1/PX19 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04707">
        <property type="entry name" value="PRELI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50904">
        <property type="entry name" value="PRELI_MSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRELI/MSF1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4033963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="200" mass="22764" checksum="EF2B65F65AAA62A8" modified="2024-10-02" version="1">MKVFSNAETFNYSWEEVSTANWRKYCPWNQKSTHVIAVDTVSRTVDPATGILRTERLITCRQSAPDWLKSLMGGSMDESQVFETSYVDPRSKTVTMVSANLTWSNLINVQETVVYRPLNDHQTSFEQAAQITALCGGWQRIKNRIEDSLVKRFHENAVKGKEGFEAVLAMSRRVFAEERERERMLLLQAQAGNIRLAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P901</accession>
    <name>A0AAN6P901_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HAM1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_39628</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854504">
        <property type="protein sequence ID" value="KAK4033895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P901"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.10">
        <property type="entry name" value="Bactericidal permeability-increasing protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017943">
        <property type="entry name" value="Bactericidal_perm-incr_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045967">
        <property type="entry name" value="HAM1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31138">
        <property type="entry name" value="CHROMOSOME 19, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31138:SF4">
        <property type="entry name" value="DUF5923 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19343">
        <property type="entry name" value="HAM1_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55394">
        <property type="entry name" value="Bactericidal permeability-increasing protein, BPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAM1-like N-terminal" evidence="2">
        <location>
            <begin position="28"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="HAM1-like N-terminal" evidence="2">
        <location>
            <begin position="225"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4033895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="742" mass="84318" checksum="C591821A5F18A99A" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P982</accession>
    <name>A0AAN6P982_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Beta-lactamase/transpeptidase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_51020</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854646">
        <property type="protein sequence ID" value="KAK4032121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P982"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058664">
        <property type="entry name" value="ARB_00930-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051478">
        <property type="entry name" value="Beta-lactamase-like_AB/R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22935:SF97">
        <property type="entry name" value="BETA-LACTAMASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22935">
        <property type="entry name" value="PENICILLIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26335">
        <property type="entry name" value="ARB_00930_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042993801" evidence="1">
        <location>
            <begin position="27"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase-related" evidence="2">
        <location>
            <begin position="106"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase-like ARB-00930-like C-terminal" evidence="3">
        <location>
            <begin position="475"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4032121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="613" mass="65961" checksum="BE2F31B16B9D06DD" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P9D7</accession>
    <name>A0AAN6P9D7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_19845</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854547">
        <property type="protein sequence ID" value="KAK4033185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P9D7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF37">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4033185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="362" mass="41474" checksum="30284A34A00F7654" modified="2024-10-02" version="1" fragment="single">RYLRSATRIPIARIHAFGQGVWPRAAAEENNMPWFSYLIHDFVPGNPLDISLFTKDMLNQGRKRHFYSQLIDILAQLRQQEFDRAGSLMPDPDGGDKPIVGNALSAALNEAQINNQKDMATLPARFSSATDFALHQHSLLAEAYELPESDMPLWLAGVQAVAVPDLKKFVLQHLDPRWEKGPFVLAHTNLRWADIIVDEALNIQGIVNWEWAATVPRQLSMPPPWLAGIPAEGIGRDVHQLEYWKFYGILTAKAARSQTCRQLAEDWRGDLLKRVDLDLAVALLHPSRFSAVYCRRILPRFHKKYFGETTKDILLRLLKDMDGADTAEIRGYMERCERYTEYLKENNLYVPPKWTDKGKWRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P9L8</accession>
    <name>A0AAN6P9L8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glucanase</fullName>
            <ecNumber evidence="9">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">C8A01DRAFT_18889</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose and cellotetraose, releasing cellobiose from the non-reducing ends of the chains.</text>
            <dbReference type="EC" id="3.2.1.91"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 7 (cellulase C) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="9"/>
    <dbReference type="EMBL" id="MU854486">
        <property type="protein sequence ID" value="KAK4034279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P9L8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016162">
        <property type="term" value="F:cellulose 1,4-beta-cellobiosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07999">
        <property type="entry name" value="GH7_CBH_EG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.100.10:FF:000001">
        <property type="entry name" value="Glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.100.10">
        <property type="entry name" value="Glycoside hydrolase, family 7, domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001722">
        <property type="entry name" value="Glyco_hydro_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037019">
        <property type="entry name" value="Glyco_hydro_7_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33753">
        <property type="entry name" value="1,4-BETA-D-GLUCAN CELLOBIOHYDROLASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33753:SF2">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00840">
        <property type="entry name" value="Glyco_hydro_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00734">
        <property type="entry name" value="GLHYDRLASE7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 9" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="7 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0732">Signal</keyword>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK4034279.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="456" mass="49112" checksum="A4EB295DA6E95355" modified="2024-10-02" version="1">MYRQVATALSFASLVLGQQVGTLTAEKHPSLPIEVCTAPGACTKEDTTVVLDSNWRWTHVTDGYSNCYTGNSWDATACPDGKTCAANCALDGAEYETTYGISTPSAGALRLNFVTKNGDGTNVGSRVYLMAGEEKYRLFNLLNKEFTMDVDVSKLPCGLNGAVYFSEMDEDGGLSRFEGNKAGAKYGTGYCDSQCPQDIKFINGEANVEGWGGTDGNSGAGKYGTCCAEMDIWEANLDATAYTPHPCKVTEQTRCETEEDCGAGDNRYAGQCDKDGCDFNSFRMGDKEFYGPEKTVDTSKPFTLVTQFVTEDGTDTGALKSIHRFYVQDGKVIPNSMTVVEGVDAVNNISDEYCAQQKTAFGDNNYFKTVGGLAAMGKSLEKMVLVLSIWDDHAVSMNWLDSNYPTDADPTKPGVARGRCDPEAGLPETVEAAHPDAYVIYSNIKVGAINSTFTAA</sequence>
</entry>
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    <name>A0AAN6PA24_9PEZI</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">C8A01DRAFT_49883</name>
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        <name type="scientific">Parachaetomium inaequale</name>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">CBS 284.82</strain>
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    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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            <dbReference type="EMBL" id="KAK4033575.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
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    <sequence length="148" mass="16208" checksum="28AC817A06D1C48B" modified="2024-10-02" version="1">MSAPESVQQFHRLLGSSSFLFLLFVAATAEAAEHLEKVRSWTGFSETVIVDPENLLARELKSRKLLDVAITDSQLYRLRGYKHGMAQPALLVVKSDGAMNIGGATDRPVLAEVWKNTQNQLQGGDVITKQGYATTGVLHLLGQKLSGW</sequence>
</entry>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
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                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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            <dbReference type="EMBL" id="KAK4034773.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="364" mass="40100" checksum="A7A4FD9525CFE076" modified="2024-10-02" version="1">MPSATPQPQLKKKASFKDRLKAWQKPPQPLEIVAEELKPRFVYEPTHAAADFSRLAVSPLSPSRQRLPPAMQILPGEEAPAVPRNSQRRPRHGHDSCDGAPRDGEPTRRHSRPSANRHSYTLVEDPFQASNAAAHVPVNARPVAWTPGTQAAGRREERPPPSEPPSQPPSDFELFIARAEAEDRERREQVLRSMSQRSATYPGNRVRPDPHRQFAAAGSSSAGRTAERSDGSGQRTSGTRYVLGSGGGVEQQRQRQERRQEGRRGHARQSSWAASYPTSGSATGNGLEKGMSPPSQPQAPAQQRGAPEPQQPIVYGIDDEFGPGREYQPQPPRTLRRQASLTQRIVQYIRPPKTAGRPVGTLVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854573">
        <property type="protein sequence ID" value="KAK4032822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PBA1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="442"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <begin position="11"/>
            <end position="24"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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        <location>
            <begin position="517"/>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="545"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4032822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="567" mass="58184" checksum="C588611664F0A387" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PBE7</accession>
    <name>A0AAN6PBE7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_50422</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
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        <lineage>
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            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854566">
        <property type="protein sequence ID" value="KAK4032897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PBE7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053157">
        <property type="entry name" value="Sterol_Uptake_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784:SF5">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="14"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="45"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="125"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4032897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="462" mass="50431" checksum="F4DD571C9D34C6DB" modified="2024-10-02" version="1">MARLRLGYTKSRTGCSRCKQRRVKCDETRPSCRACLRHGIECSLSSEPNTASPAASSAAAATPSPGSAPSPLPEPSRRSRPRLINPKPKPKPQTQLQSQPQPQPPTAGLLGDCGPEAGPSPNGSTLTPAASPATATPDPFPYLTRFVTGPPEEDTANWVFDLELLHHFSTSTYGTFQIDPTRPEMNRLWQFEVPRQAFVHIFLLHQILAVSAYHLAHLHPQSRQAYSLRASQHQNAGIRRMRPALSELSPANCHALFASSSLLFIGSLAAASTNRAADAPTIDDLVDVLILVKGIGSVLYSSQDLLRTGPLADLFVQRDSSDQPNPALDRVVLAVGDFLVEIAETEADDRVRAIVHADAYRLVSAIRDSLVRTAAPEYRVVAAWPIQMSDDLIPLLRQRNQAALALLSYYCVVFHAAELQGYWFMQGWAPGVIRDIARTMTGPWKRHSAWALGWITGHAALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PBW2</accession>
    <name>A0AAN6PBW2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ras-related and estrogen-regulated growth inhibitor-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_17843</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854442">
        <property type="protein sequence ID" value="KAK4038036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PBW2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="104"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="236"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="104"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="242"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="253"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4038036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="366" mass="40091" checksum="96AC769CF81FDD56" modified="2024-10-02" version="1">MVNSLVWSAEEAKYLKAIFRWQETAPSPDEERCRCQAEEDEQQRQQEQKPVGEFRVLVIGGRGTGKTAILTRFGQDTFHGESQPPDPFYERGCRRPITLEITPTPTLLTSPTTTLTTTTTTAPPTAGGRSKSQPTLPKQPPPLPKPKKQTYILDALEMPSPHLLSNPLLAQGLSLTEAAVLVYSVRDAASFRLAQGLAEFMREHFAPIHPSVLPSSQNGVSAVDKGRVYPVVLVGTKSDLPSSDDTDNDDDDATIKREEAGERAVSWAEGAKAAAGMRMPGSGADVPFLEVSAKTGEGVDKVFEVAGQEVLRVRRVVRERRERAQRERMMAEVGSVQTAGGEGRRKRFWLWKVLFGRRGVGGEGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PBX9</accession>
    <name>A0AAN6PBX9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_18697</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854476">
        <property type="protein sequence ID" value="KAK4034537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PBX9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052432">
        <property type="entry name" value="PITP/CRAL-TRIO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46590:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL TRANSFER PROTEIN CSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46590">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL TRANSFER PROTEIN CSR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4034537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="154" mass="16992" checksum="597ACB7EAE53D9F1" modified="2024-10-02" version="1">MEEFIPLKHIPKDLEGDEDWTYQYVEPAEGENAKLADAATRDRLLAAREALYKEYESATLEWIRNAGEDKAAAEEIKARRNAIADRLREDYWNVDPYVRARSYYDRIGVLLPGGKLDWYPAAKVEGANGVAAVAAAPAPAAPAPAVETAADDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PC18</accession>
    <name>A0AAN6PC18_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_38859</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854469">
        <property type="protein sequence ID" value="KAK4034700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PC18"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19180">
        <property type="entry name" value="SET_SpSET10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044432">
        <property type="entry name" value="Set10/Efm1_SET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF146">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4034700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="464" mass="51600" checksum="D1F399246194ACC5" modified="2024-10-02" version="1">MNERDKARFDTLLAWSRQHGAELHPSLEIYHDDISKYSLRVKPSAEGLQPGFGAVSCPAATTLSYLNALVDGPIDPSSPSPQQTGAFPPRFTQSVPPHVLGRFFLIKEYLKAEDSFWWPYLATLPSPEQVSAWALPAFWPDDDIAYLEGTNAHVAIDEIQANVKREFKQARKLLKEEDFPDVATYTQLLYKWAFTIFTSRSFRPSLILSDTTKQHLTPLLPDDVQLDDFSILQPLLDIANHSMTARYAWDTTTTTPSACRLICRDPYQPGEQVYNNYGLKTNSELLLGYGFLLPETEGLHNDYVHVRKRQQQDVSGNEDEPKTFLISLRPVAHDSSLVGRSRVSSRGPASRLALLPCFAHFEPALVEDLAGAVANTPELRRALERCGVDGAGRGQGAEVGELVERVRGALGGKVQYDYERLMEVEEGLPPPGNRNQVLATEYRAQCAKVLVAAMESLMGEEGGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PD65</accession>
    <name>A0AAN6PD65_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_38264</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854450">
        <property type="protein sequence ID" value="KAK4035242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PD65"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="139"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4035242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="188" mass="20769" checksum="24D212303AC2336E" modified="2024-10-02" version="1">MKITCTICTNPLPPPPQHTSSHHHHPKTVAVTFPCTHIHCLPCLRRNYTLSTTPIENVPFRPVQCCPNTRLPLPILRHALGLNSAEVASYRARLAEYDSPVKLYCFDRVRCGRFIPTVLRDGRVGRCRGCWGRTCVRCGGRAHSSSSSSSSSGGRCEGGGDVGKGGGVGRRKSVEEEEFRRVVREMGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PDB7</accession>
    <name>A0AAN6PDB7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_49007</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854470">
        <property type="protein sequence ID" value="KAK4034673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PDB7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="2">
        <location>
            <begin position="240"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4034673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="357" mass="39346" checksum="CBFFB79C8489847C" modified="2024-10-02" version="1">MQSTPTARLPYSPDFEAESSFPERHLDDNKTPVSGIGPGRYPQPAAAKPQVFGPNLAPLYSQGWPSPNQPFFHDSHASPHGPLVDTTTSGPFPQTASAALPQPEWASLREQPQDGRLWLPTQPEFSVEDDSDSIQSRNDSIEDFCLSLPTLPSTQKPRRRSTNRVTKPAKPPASVPSHHPAARLDRPYIPDFDYNTDFLDPSDAAAAFFPHMNYDHSAPTAGGEIEIAYRDSSSSSKVDSKRIAHKLSEKSRRNRLTIAIREIQKLLPSGSVGDDQPTSQAQKEADFVVRPGVPSSKLDVVEMAVGFIKDLKERNKEITRRLRETERDLEGCQCRQRKGGAVRESPSSTPTMEDAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PDE8</accession>
    <name>A0AAN6PDE8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_38066</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854443">
        <property type="protein sequence ID" value="KAK4035435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PDE8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4035435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="143" mass="17019" checksum="4C0ED226D1505275" modified="2024-10-02" version="1">MGFQYHSTPKKARVQGTIAYLQANRIPHFKIDVFRFHGMSKASGWRALQQLDEEDGRTYHSVYPDRRGRRKKIIPEILAQIERFIDTARLDIDVYADTVRRVVKDLNLRIYLVYEKKYISPQLRERRADYTCIILKQYPDLAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PDG2</accession>
    <name>A0AAN6PDG2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein PCF11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_17016</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
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                <person name="LaButti K."/>
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <comment type="caution">
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
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                <person name="Brannstrom I.O."/>
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                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
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                <person name="Riley R."/>
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                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
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                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854459">
        <property type="protein sequence ID" value="KAK4034982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PFC3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4034982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="173" mass="18843" checksum="181F400956BB49A5" modified="2024-10-02" version="1">MKLTSSALVNTWRRKNPSAGHAKQGAAALAAARRKSRGSKTSNSSAPLPPPPQQQPQHETLASGACAPPRRPLHQPAEVAAASLLPFAASPYVNLFLFHRHEGIWSVAWVKREDNTVWMDDGISNTSGNISNNNERTSRLRALLTKLNRWAAPVSSGPRYSQAVHRAWGVDQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PFU2</accession>
    <name>A0AAN6PFU2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Oxysterol binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_47959</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OSBP family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxoprolinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854429">
        <property type="protein sequence ID" value="KAK4038446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017168">
        <property type="term" value="F:5-oxoprolinase (ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120009">
        <property type="term" value="P:intermembrane lipid transfer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd13289">
        <property type="entry name" value="PH_Osh3p_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000369">
        <property type="entry name" value="Oxysterol binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.120:FF:000001">
        <property type="entry name" value="Oxysterol-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.680">
        <property type="entry name" value="GOLD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049517">
        <property type="entry name" value="ACX-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008040">
        <property type="entry name" value="Hydant_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002821">
        <property type="entry name" value="Hydantoinase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003692">
        <property type="entry name" value="Hydantoinase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041680">
        <property type="entry name" value="PH_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365:SF2">
        <property type="entry name" value="5-OXOPROLINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="5-OXOPROLINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19278">
        <property type="entry name" value="Hydant_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05378">
        <property type="entry name" value="Hydant_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01968">
        <property type="entry name" value="Hydantoinase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02538">
        <property type="entry name" value="Hydantoinase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15409">
        <property type="entry name" value="PH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="5" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PH" evidence="8">
        <location>
            <begin position="219"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="149"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="318"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="381"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="542"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2293"/>
            <end position="2326"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="909"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="166"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="543"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="2317"/>
            <end position="2326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4038446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="2326" mass="253261" checksum="3C7F1262014DD830" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PG08</accession>
    <name>A0AAN6PG08_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial carrier domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">C8A01DRAFT_15853</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854381">
        <property type="protein sequence ID" value="KAK4040263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PG08"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45667">
        <property type="entry name" value="S-ADENOSYLMETHIONINE MITOCHONDRIAL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="93"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="225"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK4040263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="328" mass="34410" checksum="2EB8A9B5A1D4920B" modified="2024-10-02" version="1" fragment="single">GSLTLFNQAGAVAAFTVDLLVYPLDTIKTRYQSQGHLGGSLSTAGRAPYTAARGLYQGIGTVVLATLPAAAIFFASYESAKSLLKHALPTATPAPAIHAFASSGAEMASCFVLTPAEVIKQNAQGLWRSGSAPLNRSSSLQAFHMLRHSEGGAMRTLWRGYSTLVARNLPYTAIQFPIFEHLRGHIWKQRQGHRSGMSSCSTPGPTMGDEAGATMRAGLYPLLVDTGLVNGSAAAISGSVAATITTPADVVKTRVMLGARETSDGAGGRIGVVDVVRAVVRERGIRGLFRGGALRAAWAAIGSGLYLGSYEVTKVWLRHRSPSTPSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PG69</accession>
    <name>A0AAN6PG69_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_35604</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854378">
        <property type="protein sequence ID" value="KAK4040368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PG69"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10476">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4040368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="207" mass="22927" checksum="25B672F1CBECB737" modified="2024-10-02" version="1">MSNRQLARDMQTEFQARFNAKQARREAQKAAKQDNELKKQIQTLLKKGETAQAAQKARMLLAKQAIAAQMDQAADIAELSLAQIQANNAMNRMTTMMAQSSKTMNRAQRSANPEKTLLTLEQFRSQNEEYAMSNGIYQDAMTQNTSVQVSDDAVHELLGKLADDAGVELGQELDQASTSKVEPVKEAAEPTAEAEDALQQRLRALRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PH49</accession>
    <name>A0AAN6PH49_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">lytic cellulose monooxygenase (C4-dehydrogenating)</fullName>
            <ecNumber evidence="15">1.14.99.56</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">C8A01DRAFT_35305</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the polysaccharide monooxygenase AA9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="15"/>
    <dbReference type="EMBL" id="MU854372">
        <property type="protein sequence ID" value="KAK4040652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PH49"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF10">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042933005" description="lytic cellulose monooxygenase (C4-dehydrogenating)" evidence="16">
        <location>
            <begin position="17"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="17">
        <location>
            <begin position="17"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAK4040652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="234" mass="24957" checksum="D12793FF6649E2F9" modified="2024-10-02" version="1">MKVLATLLFMAATADAHYRFSKLIVNGVAEEKEWTAVRQTKNFQGNQGVTDVNSQDMRCFQNKPGTATATVAAGDKLGFVAMSAVTHFGPVSFYMARVPEGKDINTWEAAGNVWFKVAEISAVPSAGGGGLTSGEATWPAYNKKTVEFTIPQSVPSGKYLVRVESIALHQAQNPGGAQIYLSCGQIELTSGGNGTPGPLVAFPGAYKTNDPGLLWSYYPVRTSYKAPGPDVWQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PHH4</accession>
    <name>A0AAN6PHH4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_46484</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854383">
        <property type="protein sequence ID" value="KAK4040168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PHH4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="173"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4040168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="365" mass="40423" checksum="010825D472ADF66C" modified="2024-10-02" version="1">MHISFDGVDFLGIKDLSHEDTEANVVDYRYNGQLVRVLISTTPPEGCEREGALELAWIDRLYDLSSHFDGDHGRLMKQFEGECEIAREIRDAVFPTLQRLAPSPTPSESAPVRDNTVAEYLFPHRIRLELVTKNGKLEVLLGHHRELDRARLVVPWSAMSEIGFEPGSVPTFAAKDVVLGSGLVVGPSPADVYDVAVPGVNEKVICKLVFTLDAFQRALRREMEIYGKLNKLSLDPETRISEFKGLITHGDGVVGFIISKIPAKYPSLDPIVTGTLEGGLPAPSLRRKWAAQIEHTVRELHRHGVVWGDAKPDNVVVDMDDNAWVLDFGGGGTPGWMEPSMFQTKEGDLHAVAKMKEGLLREDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PHV6</accession>
    <name>A0AAN6PHV6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Manganese lipoxygenase</fullName>
            <ecNumber evidence="3">1.13.11.45</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_45509</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(9Z,12Z)-octadecadienoate + O2 = (11S)-hydroperoxy-(9Z,12Z)-octadecadienoate</text>
            <dbReference type="Rhea" id="RHEA:18993"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:30245"/>
            <dbReference type="ChEBI" id="CHEBI:57467"/>
            <dbReference type="EC" id="1.13.11.45"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.45" evidence="3"/>
    <dbReference type="EMBL" id="MU854360">
        <property type="protein sequence ID" value="KAK4041253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PHV6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050584">
        <property type="term" value="F:linoleate 11-lipoxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043651">
        <property type="term" value="P:linoleic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034440">
        <property type="term" value="P:lipid oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.245.10">
        <property type="entry name" value="Lipoxygenase-1, Domain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056632">
        <property type="entry name" value="DUF7730"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000907">
        <property type="entry name" value="LipOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013819">
        <property type="entry name" value="LipOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036226">
        <property type="entry name" value="LipOase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11771">
        <property type="entry name" value="LIPOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24864">
        <property type="entry name" value="DUF7730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00305">
        <property type="entry name" value="Lipoxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00087">
        <property type="entry name" value="LIPOXYGENASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48484">
        <property type="entry name" value="Lipoxigenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51393">
        <property type="entry name" value="LIPOXYGENASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipoxygenase" evidence="9">
        <location>
            <begin position="524"/>
            <end position="1007"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4041253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1007" mass="113924" checksum="DC7B0DC7A701C698" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PHX6</accession>
    <name>A0AAN6PHX6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cytosolic 60S ribosomal protein Rpl13a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_34695</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854360">
        <property type="protein sequence ID" value="KAK4041283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PHX6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00392">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3250:FF:000001">
        <property type="entry name" value="60S ribosomal protein L13a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1180.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01366">
        <property type="entry name" value="Ribosomal_uL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_uL13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023563">
        <property type="entry name" value="Ribosomal_uL13_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005755">
        <property type="entry name" value="Ribosomal_uL13_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_uL13_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01077">
        <property type="entry name" value="L13_A_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="RIBOSOMAL PROTEIN L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00783">
        <property type="entry name" value="RIBOSOMAL_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4041283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="202" mass="22952" checksum="BA40F0DFC721E686" modified="2024-10-02" version="1">MSSFESVVVIDGKGHLLGRLASIVAKQLLNGQKIVVVRCEALNISGEFFRAKLKYHAYLRKMTRYNPTRGGPFHFRAPSRIFYKAVRGMIPHKTARGAAALERLKVFEGVPPPYDKKKKMVVPQALRVLRLQPGRKYCTVGRLSHEVGWKYQDVVERLEERRKAKGAAYYERKKLAARQLSEAKKTAKVDTKTTEALTAFGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PHY5</accession>
    <name>A0AAN6PHY5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_47074</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854399">
        <property type="protein sequence ID" value="KAK4039511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PHY5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4039511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="305" mass="33437" checksum="1C057342DFB8C57F" modified="2024-10-02" version="1">MYYDEEEEEDEEEEEEEEGEEEEEDTNVTFWPCHFFLGDMLLNPERFVSGFLQYCRWVIDDSFLISFAATASTLSAPRTESSISPMPAENLAIPGRCSSLVSSPATADPSPGPNVECWPLFGPLEPGTWVVVVSHDWHTTRKTRKGRRQYLSWGYPGDSLIGVPVEQLAGPDFVDAVGGVEAFLRETAPGVDGLLVGERVEEAAGMLRARWQPGEWPNEDLPADMDLLTVLDDSAARAVFRDFLADAAHVRGNLAMALQVRPDGPNWYPALPAIAPSLAPVPRDDAVFRSLDEKDAAGGANPLGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PI34</accession>
    <name>A0AAN6PI34_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Isopenicillin N synthase-like Fe(2+) 2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_34663</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854359">
        <property type="protein sequence ID" value="KAK4041358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PI34"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.330:FF:000039">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.13, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209:SF874">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209">
        <property type="entry name" value="OXIDOREDUCTASE, 2OG-FE II OXYGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isopenicillin N synthase-like Fe(2+) 2OG dioxygenase" evidence="5">
        <location>
            <begin position="225"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4041358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="382" mass="42760" checksum="7F1ED617F2EDC07F" modified="2024-10-02" version="1">MTAQELSMDLPVIDLDVFLRQPRDSPAVQAECARAADTLITYGALVLHDSRVSEHDNDTFLDLLEDYFAQPEADLRKDERPELAYQIGVTLENTEKPKCAVDEPCLHVIERLAPSERPLDISAHSPDPKCRFFWRMVEPPPYETQFPGLNAANITPEAPHIRERWGPVMNQWGTSMKDAVEGLTQMAAVGLGLPADTFKDAGRYGPHLLAPTASDLAKYGQRDTILAGFHTDLNFLTIHGRSRYPGLHIWARNTGKRIPVKIPQGNYLLVQAGKQLEHVTGGLVKAGYHEVVVNDKTVAVIEDRRARFPDRPLVRISSTFFWHLSSDYDLVPIPELADKARSVRAQQFNLGKDEGEEVQYPPMKVGEQVQSELKHIALMATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PIK5</accession>
    <name>A0AAN6PIK5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_45361</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854356">
        <property type="protein sequence ID" value="KAK4041516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PIK5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061574">
        <property type="term" value="C:ASAP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12365">
        <property type="entry name" value="RRM_RNPS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034201">
        <property type="entry name" value="RNPS1_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15481:SF0">
        <property type="entry name" value="LD23870P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15481">
        <property type="entry name" value="RIBONUCLEIC ACID BINDING PROTEIN S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="100"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="182"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="52"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="80"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="237"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="290"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="302"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4041516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="312" mass="34115" checksum="B1A82E1526F5A1F5" modified="2024-10-02" version="1">MDSPVRASEPMALDDQDRTPRSLHSRSPSPSMDRRRSDDPSPARNGRNRSPTRAAGATAGTTAARAAGLVARVPPRSRPRQATSGELRESSGSSWLTGTVQIVVERLTKNVNEDHLYEIFGQYGEIDDLDLPVNRTSGMNRGTAYILYFTETDAQAAITHMHEAQLDGSIIHVSIVLPRRKVSPSPPVARRGPRGPPANVRSVLGPSGGGAPGGRGRRSPAAGGSGRYGHRSDVYRPRSASRSRSPAASGTRRYRSRSASYTSRSRSRTPAGRGGRDHRGSRNHGRRRSPSRDSYDSYDRRSRSRSRSRERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PIX1</accession>
    <name>A0AAN6PIX1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_45146</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854352">
        <property type="protein sequence ID" value="KAK4041711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PIX1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4041711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="459" mass="51216" checksum="B0AD34974120B887" modified="2024-10-02" version="1">MSFYDTYCAICGCSLISGRIGSDAPGALRRRRAMVAQTRAARERGDPDPKKTEHEEERMDGEDWWSEDENRCYDPTLVSEESLEWLAASRCLGINPEASGNSNYTTFEAVFPFHQDCFDVLTNVLVGSRDVAKIDKDALYDAMSELVAPLDAVCLKLDYGSVSGRGRHWVSEPGEEFSVTSPATTPEVTKALERFLADDAFGLRPDSLGITREPQILLNIFRFLSGDALLALLKSSWPAFCATRRNAFWKWFLKHDMPWLTELGPLLLDKQRDGPELSYKALYLWLDKVMAPRYGMEGPFLSLANRRRIWGVCEQLAPYYVRRLQEISLDEPDPSILEHAICGHMALISDDKPPPSGSWTLQRTLFVYSADEVKHRATIFEAYWGEGGRLVGFGAVVGRQKQRVFGLNGAELPHITRTATRIAASDRVTAITVVIATADPNQATTSPPAVVAILVRTCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PJ15</accession>
    <name>A0AAN6PJ15_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_15321</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854368">
        <property type="protein sequence ID" value="KAK4040860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PJ15"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="424"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="457"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4040860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="507" mass="57367" checksum="B0164B186C85BB7A" modified="2024-10-02" version="1">MNHDKGAYRDFVQSRCQTNPCVTGLADYLRCRSGSTSTIVTLDYPRSEQPAPNPLTVSEADLAKLIDTTSTTDGRILLVENIQPHLICLLGEILDVDPVFFAGHITDFKDIEKAPPPPSLALFPSQIAEKGYLHLHYQQVLDLGSADTFKLSSYSLKSDSNVPRNVRRLPNLSGRQLALARACCSILVKKIKDSCICKSDSDVHYLMTESLTSLGLVLVDPPATTVVETLGSGGRKSYPSMLLHGGFEDFEHSTSFASFGSITSDRLPDKKSMLSNLLHYFRHQPPGFTMAEPSILSLGYYPIRIVLAEWNLYTHLMSRYFKYYEYTLHDTENRLHGSDIIDLQRWRRRSMQSRHKLTLLSEFIDHWLQQEAEKEPWNLALKDIKHTLSQLEHYNRSLEHMIPVATSMVQLLDSRRSMLEAANVSRLTLIALVFVPLSWVASLFSMSEDYSPGRKNFWVYFATALPVLILVLSLSAVQWDQLEGKLNRIGADSRRQAARRRAEVVFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PJB7</accession>
    <name>A0AAN6PJB7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Malic enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">C8A01DRAFT_14458</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(S)-malate + NAD(+) = pyruvate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:12653"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.38"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>oxaloacetate + H(+) = pyruvate + CO2</text>
            <dbReference type="Rhea" id="RHEA:15641"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="EC" id="1.1.1.38"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="10">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="10">Divalent metal cations. Prefers magnesium or manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the malic enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854350">
        <property type="protein sequence ID" value="KAK4041822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PJB7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004471">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05312">
        <property type="entry name" value="NAD_bind_1_malic_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10380:FF:000001">
        <property type="entry name" value="NAD-dependent malic enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000055">
        <property type="entry name" value="NAD-dependent malic enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10380">
        <property type="entry name" value="Malic enzyme, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015884">
        <property type="entry name" value="Malic_enzyme_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012301">
        <property type="entry name" value="Malic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037062">
        <property type="entry name" value="Malic_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001891">
        <property type="entry name" value="Malic_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010052">
        <property type="entry name" value="PRK13529.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406">
        <property type="entry name" value="MALIC ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406:SF34">
        <property type="entry name" value="NAD-DEPENDENT MALIC ENZYME, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00390">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000106">
        <property type="entry name" value="ME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00072">
        <property type="entry name" value="MALOXRDTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01274">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00919">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00331">
        <property type="entry name" value="MALIC_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Malic enzyme N-terminal" evidence="14">
        <location>
            <begin position="100"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Malic enzyme NAD-binding" evidence="13">
        <location>
            <begin position="291"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="433"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="483"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00050168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00052591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK4041822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="611" mass="67519" checksum="129D18A7AB28BC80" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PJC0</accession>
    <name>A0AAN6PJC0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Actin-related protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">C8A01DRAFT_46564</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="10">Component of the NuA4 histone acetyltransferase complex, of the INO80 chromatin remodeling complex, and of the SWR1 chromatin remodeling complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the actin family. ARP4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854385">
        <property type="protein sequence ID" value="KAK4040079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PJC0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13395">
        <property type="entry name" value="ASKHA_NBD_Arp4_ACTL6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000137">
        <property type="entry name" value="Actin-related protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="100"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK4040079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="467" mass="51228" checksum="A654E1C8C412DBBC" modified="2024-10-02" version="1">MSQQPLSSSVQPTDIYGGDEVSALVLDPGYCNTRAGFAGEEMPKQVIPSFYGHVDGRDLFGDPVITPRAGFEVRNYMNRDSVVEDWDAATRVWEHVLVQRLQPPRPTPPGKNGLNVGDDGDVEMGENGANEDATDALEKPLAENPLLMSEAPWNSAKAREKAIEVCMENWGCPAFWLSRTPVLAAFAAGKATALVLDVGGANASVTAIHDGMVLKRSVQRSPAAGVWLSSQIRSMWKNSEPKVDVVPTFMVENKKPVEAGAPADARLRAFDFPIIDSFRAFEEERVVTEFKESVVETWRGPGRYMAPGNEDYARSQPGRVFEMPDGFNQMWREQRYRVAEGMWDETAAYPAVGDEAGLSKAQTIPALIKAALDGVDVDLRPNLLGNVVVTGSTSLLNGFNDRLNHELTAMYPGLKIKIHAAGLTSERRFGAWIGGSILASLGTFHQMWISRKEYEENGPGIVEKRCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PJS1</accession>
    <name>A0AAN6PJS1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heterokaryon incompatibility protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_45507</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854360">
        <property type="protein sequence ID" value="KAK4041250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PJS1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26639">
        <property type="entry name" value="Het-6_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="16"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4041250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="609" mass="68185" checksum="0066DDCEFE21B843" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PJU5</accession>
    <name>A0AAN6PJU5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">C8A01DRAFT_33667</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854343">
        <property type="protein sequence ID" value="KAK4042318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PJU5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:endoplasmic reticulum-plasma membrane tethering"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="C2A_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="C2B_Tricalbin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21676">
        <property type="entry name" value="SMP_Mug190"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057349">
        <property type="entry name" value="C2_Mug190_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037767">
        <property type="entry name" value="C2A_Mug190-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037765">
        <property type="entry name" value="C2B_Tricalbin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47348">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 190 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47348:SF3">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 190 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25331">
        <property type="entry name" value="C2_Mug190_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25669">
        <property type="entry name" value="SMP_MUG190-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="174"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-LTD" evidence="14">
        <location>
            <begin position="244"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="469"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="658"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="630"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="693"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1067"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="52"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="630"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="702"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1083"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1096"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1129"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1160"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1192"/>
            <end position="1201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK4042318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1250" mass="138038" checksum="DCBFDC083BC0A273" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PJV2</accession>
    <name>A0AAN6PJV2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SRR1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_14948</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854360">
        <property type="protein sequence ID" value="KAK4041295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012942">
        <property type="entry name" value="SRR1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42080">
        <property type="entry name" value="SRR1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42080:SF3">
        <property type="entry name" value="SRR1-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07985">
        <property type="entry name" value="SRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRR1-like" evidence="1">
        <location>
            <begin position="228"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4041295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="417" mass="45587" checksum="F2713095B1E3FF9C" modified="2024-10-02" version="1">MDATGTFDAAQILDAKSTFNAPTVPRDGQATASRAETRAKIQAKYDAGAPLYTKDDFRRVVEVFDRAMLEGGMHEHRLAVRGIDGVRVRFVLKVGAFASIKVPGKDTTLKFILQDVRIKHHSIEMMTGRNNSSSDADLPLAVAALPFSVVHTGAMVNKTTGQTMAGRPAPWDWRDSSAVAARLAMFWPGWEITETCSHVWAIFLGLVPVVVDRSVLARADVVCLPGVIDKVVAFGCGSMAAADRESEKRVGVQHALVLSVRHALLARANRRRAYGWAAVGEVRCYAQDAGYQPTDRGGLAEVGITVLEDPRGLLEVDSTSVVVSFAPDLPLRQIVADIARPAALIWPRVTDADGGPQCDPVSPRVRRMIKDYYVAVECPFDEPEWKSSNPVVYIRKTLPWTLWGGVQTNMIPLMLNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PJW8</accession>
    <name>A0AAN6PJW8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Inhibitor of apoptosis-promoting Bax1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_15729</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854378">
        <property type="protein sequence ID" value="KAK4040394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PJW8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd10429">
        <property type="entry name" value="GAAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006214">
        <property type="entry name" value="Bax_inhibitor_1-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291">
        <property type="entry name" value="BAX INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291:SF50">
        <property type="entry name" value="PROTEIN LIFEGUARD 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01027">
        <property type="entry name" value="Bax1-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4040394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="276" mass="30767" checksum="1481E74309F7D5FE" modified="2024-10-02" version="1">MSANVKYTPAPQEDPDVNYTQPPPSYQAESSSAQDQDRLFGGPRSSEDNLPDDFKFGGSVAEATVEIRNQFIRKVYTILTVQLIATGAVSALSFMSEGYKAWIQSHPGIVWVSLFGSMVCMGLTYWKRHSYPTNLLFLSAFTLLEAYTISVIVSFYSAAIVLNAVFLTAGIFLFLTAFACQTKYDFTSWMPYLFGALWGLVIFGFMSFFLPHTSTTELVYGLLTALVFSGYVLVDTQLVLRKHHVEEEIAAAISLYLDIINLFLAILRILNSQSNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PK60</accession>
    <name>A0AAN6PK60_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GPI-anchored wall transfer protein</fullName>
            <ecNumber evidence="9">2.3.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">C8A01DRAFT_45322</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">A acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Probable acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Endoplasmic reticulum membrane</location>
            <topology evidence="2 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the PIGW family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.-.-" evidence="9"/>
    <dbReference type="EMBL" id="MU854355">
        <property type="protein sequence ID" value="KAK4041578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PK60"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032216">
        <property type="term" value="F:glucosaminyl-phosphatidylinositol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009447">
        <property type="entry name" value="PIGW/GWT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20661">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS W PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20661:SF0">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS W PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06423">
        <property type="entry name" value="GWT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017321">
        <property type="entry name" value="GWT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 9" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="252"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="276"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="322"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="356"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="394"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="448"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="472"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU280819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK4041578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="503" mass="54419" checksum="1F4BED2165A6F5CF" modified="2024-10-02" version="1">MADLANDMAAAAAARSYKQLKEDFVSNLSGGSVAEIAQVCAVAPVVALLWSALQARQTFFKPYNALAFAVDFLLNVGALLLSVTLYSSVPLLLNILLLAPAALVYFGPSDSPSARRKKPQLPPNAPSKTAPGPPGALSTKPFLTNYRGNMMVVTCICILAVDFRLFPRRFAKVETWGTSLMDMGVGSFVFSAGIVASRPVLKERADGRATPLATRLMRSLRHSLPLLALGVVRLLSVKGLDYAEHVTEYGVHWNFFFTLGFLPPFVALFQSALRLVPSYAGLAILLGVVYQVLLESTELKAYILAGPRTDFLSMNREGIFSFWGYLAIFLAGQDTGMLVLPRSLSPGATSSKRKTLLLNLAGWSAVWVALYLLCTDYTYGAGLTVSRRLANLPYILWVVASNSALVLAFCLVDTLLFPAFYRAPDARAEREAYDAATSRVLRAFNRNGLAVFLLANLLTGLVNMTVRTLDVGRIATMGILGGYMGALTAAAVVLDMYDITIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PKF3</accession>
    <name>A0AAN6PKF3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">MPN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">C8A01DRAFT_16004</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M67C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854384">
        <property type="protein sequence ID" value="KAK4040105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PKF3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061578">
        <property type="term" value="F:K63-linked deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140492">
        <property type="term" value="F:metal-dependent deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070536">
        <property type="term" value="P:protein K63-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08066">
        <property type="entry name" value="MPN_AMSH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000033">
        <property type="entry name" value="AMSH-like protease sst2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044098">
        <property type="entry name" value="STAMBP/STALP-like_MPN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12947">
        <property type="entry name" value="AMSH-LIKE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12947:SF13">
        <property type="entry name" value="FI19924P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102712">
        <property type="entry name" value="JAB1/MPN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="10">
        <location>
            <begin position="357"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="117"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="177"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="213"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="323"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="248"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="268"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK4040105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="534" mass="60428" checksum="4678B984B3F47CD3" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PKQ0</accession>
    <name>A0AAN6PKQ0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_34139</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854351">
        <property type="protein sequence ID" value="KAK4041760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PKQ0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4041760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="245" mass="27510" checksum="1C96AACFE321D443" modified="2024-10-02" version="1" fragment="single">MEMVIPPRDHGPSTYRYTWDENGEVEQVTSTTTTNRVRPDSRTLSSTERLPPGHRRRQSAQWPFQSIITDTEEPASPSSPSHHHRRTTATSQRYSAWHPSLLQQLHPLASNPYIPTPTHDPESRPRPRPRSGSGAIIPPEYVRTLLHSTSPESLSRRVHDASSRSRTATPHLVAGAANARHRSRVADFEGFQVQIRDEDPDGEGVFSEMDLGIMERVDSREGGVVHGVDVDGREEEHQRFLKAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PKT9</accession>
    <name>A0AAN6PKT9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">YL1 nuclear protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_15300</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS72/YL1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854367">
        <property type="protein sequence ID" value="KAK4040889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PKT9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013272">
        <property type="entry name" value="Vps72/YL1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046757">
        <property type="entry name" value="YL1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13275:SF4">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 72 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13275">
        <property type="entry name" value="YL-1 PROTEIN TRANSCRIPTION FACTOR-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05764">
        <property type="entry name" value="YL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08265">
        <property type="entry name" value="YL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00993">
        <property type="entry name" value="YL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vps72/YL1 C-terminal" evidence="3">
        <location>
            <begin position="598"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="284"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="693"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="62"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="98"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="114"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="194"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="373"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="481"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="500"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="510"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="535"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="693"/>
            <end position="711"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4040889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="725" mass="78124" checksum="8F370622C8D7A7E1" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PLH0</accession>
    <name>A0AAN6PLH0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_44143</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854334">
        <property type="protein sequence ID" value="KAK4042927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PLH0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39218">
        <property type="entry name" value="OXIDOREDUCTASE 14 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12110)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39218:SF1">
        <property type="entry name" value="OXIDOREDUCTASE 14 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12110)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4042927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="92" mass="10506" checksum="3065DBBA0C32B7B6" modified="2024-10-02" version="1">MVSRIVFWTGFGLVVRFWQLGIEMRPFFNRKSLWAYPVFGGVGASFGYWLQGVDERQTRLLQDRKQAILEKRARRAEREASAAAAAPSEVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PLN7</accession>
    <name>A0AAN6PLN7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RF-1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_32836</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854332">
        <property type="protein sequence ID" value="KAK4043047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PLN7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000065">
        <property type="entry name" value="Peptidyl-tRNA hydrolase domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052405">
        <property type="entry name" value="Mito_Transl_Release_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46203:SF1">
        <property type="entry name" value="MITOCHONDRIAL TRANSLATION RELEASE FACTOR IN RESCUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46203">
        <property type="entry name" value="PROBABLE PEPTIDE CHAIN RELEASE FACTOR C12ORF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="Release factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Prokaryotic-type class I peptide chain release factors" evidence="6">
        <location>
            <begin position="54"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="14"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="128"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="132"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="196"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4043047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="220" mass="24132" checksum="E9C459B1EB350569" modified="2024-10-02" version="1">MLRPLSSLRALLRRAGIPESHHGPPISRPALRSRFTTSPAANLKQLPPRPKHPPESEIEESFLKGSGPGGQKINKTSSAVQLKHIPTGLVVKSQATRSRTQNRKIARDLLALKLDAIANGDQSRTAVVGDVKRKRAASKAKKSRRKYRKLVDAGAGAGSEGEGQQVEEGREQGGEEEEGEEWEVVEETEEGEVETEAERAQDPETERVQPIEVDNTKKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PM43</accession>
    <name>A0AAN6PM43_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_12930</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854326">
        <property type="protein sequence ID" value="KAK4043554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PM43"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF31">
        <property type="entry name" value="POLYAMINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="259"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="366"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="402"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="443"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="473"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="502"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="539"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="135"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="68"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="79"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4043554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="614" mass="67062" checksum="738E0040FD3B500C" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PMF7</accession>
    <name>A0AAN6PMF7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_34181</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HMGA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854351">
        <property type="protein sequence ID" value="KAK4041804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PMF7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010557">
        <property type="term" value="P:positive regulation of macromolecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017956">
        <property type="entry name" value="AT_hook_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000637">
        <property type="entry name" value="HMGI/Y_DNA-bd_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23341:SF2">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN HMG-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23341">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEINS HMG-A AND C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00929">
        <property type="entry name" value="ATHOOK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00384">
        <property type="entry name" value="AT_hook"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00354">
        <property type="entry name" value="HMGI_Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="46"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="161"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4041804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="194" mass="20060" checksum="2E6829DFBBB20E98" modified="2024-10-02" version="1">MASTPPPTIATDPQTTKRKRGRPPLSPSQRKPKPVPSGRPRGRPKGSGVKSAANKTGAGVKKTAAADPTTPLRRGRGRPRKDASVKVEKLMDAAVAGAAGDGGEAATPAGQVKRGRGRPKGSGKKAVTEKETPAKRKGPTTPARGGPGRGRRSAGSAAKAEEEDNDEEDGEGEEGVDEGDVDAEEQEDEEEEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PMP7</accession>
    <name>A0AAN6PMP7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_12666</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854323">
        <property type="protein sequence ID" value="KAK4043893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PMP7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4043893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="223" mass="25203" checksum="02A4F03C95AC28A1" modified="2024-10-02" version="1" fragment="single">PYRHTIYFLGLLITLGPHDPLSRTLQLHIPSTYTPAEARAMLDHSNDQLRLHPTRTFTPLPISHNSETHTLHVDLTADALCLNNLEDASTLRLLPRGRSLPDVLPCLQQARHLAVPWTLTPFPVPCRRCGDHALRETLPGRNPVCPRSSNRSVHAWEQQLPEELHALWPGQFPALERVYFVVDTGRFPGAVRLKRGETPDNLPESEFLAPRGMGYDVDSDDWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PMX7</accession>
    <name>A0AAN6PMX7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Proline-rich protein LAS17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_32091</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854324">
        <property type="protein sequence ID" value="KAK4043772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PMX7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071933">
        <property type="term" value="F:Arp2/3 complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045010">
        <property type="term" value="P:actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01205">
        <property type="entry name" value="EVH1_WASP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000281">
        <property type="entry name" value="Actin associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033927">
        <property type="entry name" value="WASPfam_EVH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000697">
        <property type="entry name" value="WH1/EVH1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003124">
        <property type="entry name" value="WH2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00568">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00461">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50229">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51082">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WH1" evidence="3">
        <location>
            <begin position="17"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="WH2" evidence="4">
        <location>
            <begin position="576"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="122"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="241"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="241"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="256"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="275"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="334"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="368"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="395"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="431"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="594"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="608"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="631"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4043772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="667" mass="69389" checksum="D8DC05FB4E7DD24F" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PND1</accession>
    <name>A0AAN6PND1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ATP-binding cassette transporter YOR1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">C8A01DRAFT_32822</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854332">
        <property type="protein sequence ID" value="KAK4043033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18597">
        <property type="entry name" value="ABC_6TM_YOR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18606">
        <property type="entry name" value="ABC_6TM_YOR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000565">
        <property type="entry name" value="ABC bile acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002040">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000010">
        <property type="entry name" value="Multidrug resistance-associated ABC transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF464">
        <property type="entry name" value="ABC-TYPE TRANSPORTER CICA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="189"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="355"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="384"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="466"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="881"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="916"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="993"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1018"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="190"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="596"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="881"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="1192"/>
            <end position="1455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="299"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="565"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1310"/>
            <end position="1341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="33"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="68"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="302"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="572"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1318"/>
            <end position="1339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK4043033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1480" mass="162709" checksum="459AA3E624E9CD1C" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PQ44</accession>
    <name>A0AAN6PQ44_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">calcium/calmodulin-dependent protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">C8A01DRAFT_44438</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.17" evidence="2"/>
    <dbReference type="EMBL" id="MU854339">
        <property type="protein sequence ID" value="KAK4042550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PQ44"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004683">
        <property type="term" value="F:calcium/calmodulin-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000449">
        <property type="entry name" value="Calcium/calmodulin-dependent protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000278">
        <property type="entry name" value="Calcium/calmodulin-dependent protein kinase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="7 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="23"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="319"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="332"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK4042550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="400" mass="44908" checksum="EC633048F900531A" modified="2024-10-02" version="1">MSFSNMLNRLHGQPESYDKKAKYRFGRTLGAGTYGIVREAEGPDGRVAIKIILKKVVRGNERMVLDELDMLQRLQHPHIVKFVDWFESRDKYYIVTELATGGELFDRICQQGKFTEKDASQTIKQVLGAVDYLHQNNVVHRDLKPENLLYLTKDLDSDLVLADFGIAKTLGTKDEVLTTMAGSFGYAAPEVMLKQGHGKPVDMWSLGIITYTLLCGYPPFRSENLQDLIDECSACRVVFHERYWKDVSDDAKDFILNLLRSKPEERWSSERALAHPWLSGQNASDHNLLPEIRAYLTRARLRRGIEMVKLANRIEALKMQEEDPDNSDMPKDATVSAPAAARAPAEDASGSGSGGGEGGKRTLSKTIKGAIFREVVLAKVREMKEQEETLKVTEEASKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PQC7</accession>
    <name>A0AAN6PQC7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_43664</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854328">
        <property type="protein sequence ID" value="KAK4043349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PQC7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4043349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="225" mass="25068" checksum="2826BF3A10A9DC50" modified="2024-10-02" version="1">MTESTQYERDLRSANKEWRRGKDSAVKWSHGRRHLTGISFCDDGRIENGATAPEHMWAKSRPEKRPDRRPTKWHHFTKTTYNIAKPRSISDMPSSRRRAVSHAQTEIDDAATSSPLDLSLTSPTVPSLTRTPSASTGDAGVLYSFDRADTPGRPLTLEVFVKNTSGKETERLVEKEYEVLDGNGEAVRGRRARAVLRKGGSVEAEKESEGGLDAEREVEGGFELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PRP6</accession>
    <name>A0AAN6PRP6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nucleotide-diphospho-sugar transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_12433</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854321">
        <property type="protein sequence ID" value="KAK4044069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PRP6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000136">
        <property type="term" value="C:mannan polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.20:FF:000004">
        <property type="entry name" value="Glycosyltransferase family 32 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039367">
        <property type="entry name" value="Och1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834">
        <property type="entry name" value="INITIATION-SPECIFIC ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834:SF8">
        <property type="entry name" value="TRANSFERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14040)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="372"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4044069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="444" mass="50860" checksum="02E3BBC0CFAFE528" modified="2024-10-02" version="1">MIAKLGSPLGTPSLAATTAQFRNRLPTQFRRALPIYIAAVCLILFIFNLNLFQSSGRVPLGRPTVSGPNAPKVRSEFPKKIWQTWKVNPLKFEERDLNTARSWLGKNPDYRYEVLTDDNDLRYVEFHFGPDGFNRPDIVNFYRDVKAAIVKADLLRYMVMYAEGGLYADIDVEALKPLSKFIPERYAEKDIDMVIGVEIDEPDWKDHPILGPKSRSFCQWTFMCKPQLPVMMRLIEKIMSWLNGVAKEQGVSLSEVDLDFDQIISGTGPSAFTEAIMTEMDLHKEDPRTKIDWDLFHDLDESKIVSRVLVLTVEAFAAGQGHSQSGNHEARAALVRHHYHASNWPSRHPRYAHPAYGEVERCNWNPECAEEKRKADEEKKKKQKEASERKKKEAEEASRKKKEEDEAAARKKKEEEAAAKEKPKEVTDQGEKAEQPKKQEKKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PS78</accession>
    <name>A0AAN6PS78_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">BZIP transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">C8A01DRAFT_42779</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Positive regulator of amino acid starvation-induced autophagy.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Golgi apparatus</location>
            <location evidence="4">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SCOC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854319">
        <property type="protein sequence ID" value="KAK4044339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PS78"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019357">
        <property type="entry name" value="SCOC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21614:SF0">
        <property type="entry name" value="GEO08385P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21614">
        <property type="entry name" value="SHORT COILED COIL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10224">
        <property type="entry name" value="DUF2205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK4044339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="146" mass="16063" checksum="B44E85FF2B0F182E" modified="2024-10-02" version="1">MGDASLHKAASPDWSDSSSGSSLDHPIHAPKPVRPKLPSRKSSGTMIVPRDSTDVGPVDLHVGPDDVRAMSPRRTSEDIQTLGKEARAELQRHAKALQDSLVTLFNRIEAVKEEHDKLDNHNKFLQKYIGDLMSTSKITSSSRSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PTN5</accession>
    <name>A0AAN6PTN5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Enhancer of mRNA-decapping protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_42578</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EDC3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854317">
        <property type="protein sequence ID" value="KAK4044671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PTN5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031087">
        <property type="term" value="P:deadenylation-independent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033962">
        <property type="term" value="P:P-body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10260:FF:000007">
        <property type="entry name" value="YjeF N-terminal domain-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10260">
        <property type="entry name" value="YjeF N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025762">
        <property type="entry name" value="DFDF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019050">
        <property type="entry name" value="FDF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004443">
        <property type="entry name" value="YjeF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036652">
        <property type="entry name" value="YjeF_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13612">
        <property type="entry name" value="ENHANCER OF MRNA-DECAPPING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13612:SF0">
        <property type="entry name" value="ENHANCER OF MRNA-DECAPPING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09532">
        <property type="entry name" value="FDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03853">
        <property type="entry name" value="YjeF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01199">
        <property type="entry name" value="FDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64153">
        <property type="entry name" value="YjeF N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51512">
        <property type="entry name" value="DFDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51385">
        <property type="entry name" value="YJEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DFDF" evidence="7">
        <location>
            <begin position="262"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="YjeF N-terminal" evidence="6">
        <location>
            <begin position="442"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="62"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="294"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="68"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="141"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="191"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="232"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="294"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="339"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="361"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="407"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4044671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="756" mass="81537" checksum="54290CAAE61B115B" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SKI3</accession>
    <name>A0AAN6SKI3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ankyrin repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_41814</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854714">
        <property type="protein sequence ID" value="KAK4031736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SKI3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051631">
        <property type="entry name" value="Ankyrin-KH/SAM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031353">
        <property type="entry name" value="NACHT_sigma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23206">
        <property type="entry name" value="MASK PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23206:SF7">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17106">
        <property type="entry name" value="NACHT_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NACHT-NTPase sigma" evidence="5">
        <location>
            <begin position="13"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="6">
        <location>
            <begin position="93"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="598"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="631"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="664"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="697"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="730"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="766"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="801"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="832"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="865"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="895"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="928"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="994"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1030"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4031736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1131" mass="123937" checksum="83B2588BE2136050" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SL12</accession>
    <name>A0AAN6SL12_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Acyltransferase ChoActase/COT/CPT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">C8A01DRAFT_42265</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the carnitine/choline acetyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854929">
        <property type="protein sequence ID" value="KAK4031258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SL12"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004092">
        <property type="term" value="F:carnitine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009437">
        <property type="term" value="P:carnitine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.20:FF:000003">
        <property type="entry name" value="Carnitine acetyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000025">
        <property type="entry name" value="Carnitine acetyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.70:FF:000003">
        <property type="entry name" value="Carnitine acetyl transferase FacC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.20">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042572">
        <property type="entry name" value="Carn_acyl_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="CARNITINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589:SF29">
        <property type="entry name" value="MITOCHONDRIAL CARNITINE O-ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00440">
        <property type="entry name" value="ACYLTRANSF_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Choline/carnitine acyltransferase" evidence="10">
        <location>
            <begin position="79"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="419"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="601"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="601"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="385"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600542-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK4031258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="634" mass="70750" checksum="056A1329FE629FE3" modified="2024-10-02" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SL13</accession>
    <name>A0AAN6SL13_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Carbohydrate-binding module family 18 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_21242</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854763">
        <property type="protein sequence ID" value="KAK4031559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SL13"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.10">
        <property type="entry name" value="Endochitinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001002">
        <property type="entry name" value="Chitin-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018371">
        <property type="entry name" value="Chitin-binding_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036861">
        <property type="entry name" value="Endochitinase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00187">
        <property type="entry name" value="Chitin_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57016">
        <property type="entry name" value="Plant lectins/antimicrobial peptides"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00026">
        <property type="entry name" value="CHIT_BIND_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50941">
        <property type="entry name" value="CHIT_BIND_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042941916" evidence="3">
        <location>
            <begin position="18"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-1" evidence="4">
        <location>
            <begin position="35"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="38"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="52"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4031559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="123" mass="12260" checksum="840661149D920B96" modified="2024-10-02" version="1">MLPHLATLLLLPLGALAAAVSREDLTLAPRAVSPDMSCGASKSYTCPSSAACCSQHGWCGATEAFCLTTAGCQTRYSNASSACYAPKPGVSVSIDGTCGSTGAGKNGYRCPGNATVTSCCSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SLG4</accession>
    <name>A0AAN6SLG4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_51462</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854801">
        <property type="protein sequence ID" value="KAK4031455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SLG4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004334">
        <property type="term" value="F:fumarylacetoacetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009072">
        <property type="term" value="P:aromatic amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3020.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.230">
        <property type="entry name" value="Fumarylacetoacetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005674">
        <property type="entry name" value="CocE/Ser_esterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015377">
        <property type="entry name" value="Fumarylacetoacetase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036462">
        <property type="entry name" value="Fumarylacetoacetase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000383">
        <property type="entry name" value="Xaa-Pro-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013736">
        <property type="entry name" value="Xaa-Pro_dipept_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050585">
        <property type="entry name" value="Xaa-Pro_dipeptidyl-ppase/CocE"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00976">
        <property type="entry name" value="CocE_NonD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43056:SF10">
        <property type="entry name" value="COCE_NOND FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G00600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43056">
        <property type="entry name" value="PEPTIDASE S9 PROLYL OLIGOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09298">
        <property type="entry name" value="FAA_hydrolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02129">
        <property type="entry name" value="Peptidase_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08530">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00939">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63433">
        <property type="entry name" value="Fumarylacetoacetate hydrolase, FAH, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xaa-Pro dipeptidyl-peptidase C-terminal" evidence="3">
        <location>
            <begin position="561"/>
            <end position="830"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4031455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="839" mass="93460" checksum="769A6E21E1DEF0C8" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SM35</accession>
    <name>A0AAN6SM35_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_41211</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854620">
        <property type="protein sequence ID" value="KAK4032352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SM35"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000257">
        <property type="entry name" value="Calcium/calmodulin-dependent protein kinase type I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000153">
        <property type="entry name" value="Calcium/calmodulin-dependent protein kinase type I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="23"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="333"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="335"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="358"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="372"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="418"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4032352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="498" mass="53626" checksum="92A9CFD981216BE9" modified="2024-10-02" version="1">MSAVAAAQAAGDRQPPQVQPCRYKVGKVLGAGSYSVVKECIHIDTGRYYAAKVINKRLMAGREHMVRNEIAVLKKVSMGHQNILTLVDYFETMNNLYLVTDLALGGELFDRICRKGSYYESDAADLIRAVLSAVAYLHDHGIVHRDLKPENLLFRTPEDNADLLIADFGLSRIMDEEQFHVLTTTCGTPGYMAPEIFKKTGHGKPVDLWALGVITYFLVCGYTPFDRDSDFEEMQAILNADYSFTPLEYWRGVSDSAKDFIRRCLTIDPAKRMTAHEALQHPFVAGWARVAAAGGEGADKGTNLLPTVKKNFNARRTLHAAIDTVRAINKLREGQAGGGGGGGAGGFMNGLRSREPAGRGGNGGNGNGNGNGNQNQGANAQQQQQQPKKEDSGVEVGMAGQQQQGQGQGQSHDSGYDTQTQTQTQTQGSTTATTTTQGTTGAGGNDGDDVRMEDAPFQSQQQGHLPPAYAVPASLRPGSEANRVVETSKGLWSGGSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SM87</accession>
    <name>A0AAN6SM87_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mitochondrial transcription factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_41253</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Mitochondrial transcription factor that confers selective promoter recognition on the core subunit of the yeast mitochondrial RNA polymerase. Interacts with DNA in a non-specific manner.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854624">
        <property type="protein sequence ID" value="KAK4032310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SM87"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034245">
        <property type="term" value="C:mitochondrial DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034246">
        <property type="term" value="F:mitochondrial transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006391">
        <property type="term" value="P:transcription initiation at mitochondrial promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.100">
        <property type="entry name" value="Ribosomal RNA adenine dimethylase-like, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001737">
        <property type="entry name" value="KsgA/Erm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023165">
        <property type="entry name" value="rRNA_Ade_diMease-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727">
        <property type="entry name" value="DIMETHYLADENOSINE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727:SF17">
        <property type="entry name" value="DIMETHYLADENOSINE TRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4032310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="619" mass="69890" checksum="A4E3AFEDFCB8D125" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SMG8</accession>
    <name>A0AAN6SMG8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Matrin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">C8A01DRAFT_50685</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3A2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854597">
        <property type="protein sequence ID" value="KAK4032550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SMG8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.2690:FF:000002">
        <property type="entry name" value="Splicing factor 3a subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052092">
        <property type="entry name" value="SF3A2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031781">
        <property type="entry name" value="SF3A2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23205">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23205:SF0">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16835">
        <property type="entry name" value="SF3A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01050">
        <property type="entry name" value="CactinC_cactus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Matrin-type" evidence="11">
        <location>
            <begin position="54"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK4032550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="247" mass="27780" checksum="A286C14C24EC7B87" modified="2024-10-02" version="1">MDYQNRAGSKFGGGGVASHSASNADRRERLRKLALEQIDLDKDPYIFKNHLGSFECRLCLTVHQNDGSYLAHTQGKKHQTNLARRAAREQKEGKGEVDPHTGLPVGVVGAGFAALGLGAGGPRKNVVKIGRPGYKITKVRDPITRQQGLLFQLQYPDIGTGVAPKWQVMSAFSQRVEEPDRNFQYLLVAAEPYETCGFKIPARELDKREGRQFEYWDPDAKEYWVQIMFMTEREERFNAAPGLTGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SMS9</accession>
    <name>A0AAN6SMS9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">protein-ribulosamine 3-kinase</fullName>
            <ecNumber evidence="1">2.7.1.172</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_19915</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>N(6)-D-ribulosyl-L-lysyl-[protein] + ATP = N(6)-(3-O-phospho-D-ribulosyl)-L-lysyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48432"/>
            <dbReference type="Rhea" id="RHEA-COMP:12103"/>
            <dbReference type="Rhea" id="RHEA-COMP:12104"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:90418"/>
            <dbReference type="ChEBI" id="CHEBI:90420"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.172"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:48433"/>
        </physiologicalReaction>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.172" evidence="1"/>
    <dbReference type="EMBL" id="MU854552">
        <property type="protein sequence ID" value="KAK4033087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SMS9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102193">
        <property type="term" value="F:protein-ribulosamine 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016477">
        <property type="entry name" value="Fructo-/Ketosamine-3-kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12149">
        <property type="entry name" value="FRUCTOSAMINE 3 KINASE-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12149:SF8">
        <property type="entry name" value="PROTEIN-RIBULOSAMINE 3-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03881">
        <property type="entry name" value="Fructosamin_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00048655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4033087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="302" mass="34540" checksum="51EC57D3476504E9" modified="2024-10-02" version="1">MKYSFQDLPKSGKVVRVHQLRLSNWCDTTRYDVELPDGTLESFFEKRAFGENGADLIQAHWHSESSIFKFIPEFTPRPIASGAYRSNPDAHYILMEFEDMDNETVPGPEEYMAAPAALQLRSLGQSPAGKFGFPVATLFGHLKHSNSWQSSWQVWWTNHMKFILEREEEIRGQHTEQNTRLVDDYMSKVLPRYLGPLESGGRSIQPALCHTDLWPGNVKFKTDSGSAVVFDANALWAHSEVELGIIRNPTSQLGDAFIEAYLKKVPISKPREDFDSRIIMYMIRHEVCRASIYPDDPTLRDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SMU6</accession>
    <name>A0AAN6SMU6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_50265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854553">
        <property type="protein sequence ID" value="KAK4033073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SMU6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4033073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="125" mass="13282" checksum="A13FE993023493D1" modified="2024-10-02" version="1">MANTTCPSASIPAIESLPVPQNINLMIIPGTDTAARPMVPCCAPNPVQLVNDCWLWCEIPASYFNGTDKEGARQASSACLETNGRNLTGSRITAWQFNAAGRVGTGSVREIGLWVLAVSGLVYML</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SMW5</accession>
    <name>A0AAN6SMW5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitochondrial intermediate peptidase</fullName>
            <ecNumber evidence="4">3.4.24.59</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Octapeptidyl aminopeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">C8A01DRAFT_40420</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.</text>
            <dbReference type="EC" id="3.4.24.59"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15">Binds 1 zinc ion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the peptidase M3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.59" evidence="4"/>
    <dbReference type="EMBL" id="MU854550">
        <property type="protein sequence ID" value="KAK4033133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SMW5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06457">
        <property type="entry name" value="M3A_MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.10">
        <property type="entry name" value="Neurolysin, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033851">
        <property type="entry name" value="M3A_MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024077">
        <property type="entry name" value="Neurolysin/TOP_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804:SF79">
        <property type="entry name" value="MITOCHONDRIAL INTERMEDIATE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PROTEASE M3 THIMET OLIGOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 15" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 15" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9 15" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M3A/M3B catalytic" evidence="16">
        <location>
            <begin position="295"/>
            <end position="786"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAK4033133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="797" mass="89307" checksum="E44CB3487F5FC569" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SN35</accession>
    <name>A0AAN6SN35_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_39794</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854512">
        <property type="protein sequence ID" value="KAK4033749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SN35"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050218">
        <property type="term" value="F:propionate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43347">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43347:SF3">
        <property type="entry name" value="ACYL-COA SYNTHETASE SHORT-CHAIN FAMILY MEMBER 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acetyl-coenzyme A synthetase N-terminal" evidence="4">
        <location>
            <begin position="7"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="73"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="3">
        <location>
            <begin position="553"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4033749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="692" mass="75880" checksum="7D38EA93A6BE1D92" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SN36</accession>
    <name>A0AAN6SN36_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">P-type Na(+) transporter</fullName>
            <ecNumber evidence="19">7.2.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">C8A01DRAFT_40338</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>K(+)(in) + ATP + H2O = K(+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:75815"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>Na(+)(in) + ATP + H2O = Na(+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:14634"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IID subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.3" evidence="19"/>
    <dbReference type="EMBL" id="MU854545">
        <property type="protein sequence ID" value="KAK4033210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SN36"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008554">
        <property type="term" value="F:P-type sodium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000016">
        <property type="entry name" value="Calcium-transporting P-type ATPase putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000193">
        <property type="entry name" value="Plasma membrane calcium-transporting ATPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000015">
        <property type="entry name" value="Sodium ion P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006414">
        <property type="entry name" value="P-type_ATPase_IID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01523">
        <property type="entry name" value="ATPase-IID_K-Na"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0915">Sodium</keyword>
    <keyword evidence="17" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="12" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 22" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="156"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="345"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="372"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="819"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="856"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="902"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="943"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="996"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="1028"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="23">
        <location>
            <begin position="78"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00035017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00035029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00049499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KAK4033210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1070" mass="114083" checksum="AAC0551CCB75FB30" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SNF6</accession>
    <name>A0AAN6SNF6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_39954</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854521">
        <property type="protein sequence ID" value="KAK4033585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SNF6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4033585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="404" mass="44146" checksum="105D97C69CD6705A" modified="2024-10-02" version="1">MSSSQPAAMPTTAPLAVPFTIDNVISGMLAFPSSPDVYRIRLQREHAAGGPTIKYLAAPNTARAFNGPDAYQRRLTNLAFDHVLAGDWVVGRLSVAGGGDKLELNSTHGPDALSDLGLGSAEPAWCGTTVDEIDCAEGPASARWTTVVNAAGEEISVPKPTDLQCMDYISASVIPTPQGVAYPGREVVRVSDWIPGHWAGIENETRAYRIIEERDPVLTPRFLAHVTENDSRVVGFLLEHVPNAREAGPADLDKCRAVLGRLHALGIAKRRLSRHSFLVRDDGSVLVRGPFTGSPGEASEEVLRAEMESLERVLAQSPSAFENQVARMLRLADPQRVNLLGEFQKAHGVVVLFVYWQEELEGRITLTLEEHGILAKEYEDNDFAWTKELQEQAEKRFGPCAHEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SNQ6</accession>
    <name>A0AAN6SNQ6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_38360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854453">
        <property type="protein sequence ID" value="KAK4035156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SNQ6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034444">
        <property type="entry name" value="Nuo17.8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42100">
        <property type="entry name" value="OXIDOREDUCTASE 178 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04320)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42100:SF1">
        <property type="entry name" value="OXIDOREDUCTASE 178 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04320)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="9"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4035156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="174" mass="19364" checksum="79710F717CCDAD3C" modified="2024-10-02" version="1">MSALRQTAAQIARQARAARPSGARNTRSYASGHGHHEAPHTVEESLGPAFYITLSTFVGSVFVYQISRPGENGELSTMHKWARNLSDYGTEWETKNHLMTAALEQAAHDRHLLYGAERSKHFELTYPEVFTQGSPFNVPAGHYPNISKVVAHYQKQHHDEEARKAKKLAAAASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SNX9</accession>
    <name>A0AAN6SNX9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_49380</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854491">
        <property type="protein sequence ID" value="KAK4034183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SNX9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37451">
        <property type="entry name" value="MARVEL DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37451:SF4">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="7">
        <location>
            <begin position="34"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="240"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="224"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="240"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="257"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="314"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4034183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="327" mass="35840" checksum="32B309941EAC4403" modified="2024-10-02" version="1">MADAAVPQQPYIAPAAVAHAEKEQYIQQTPVWVVAVRGVQILLSIIILGMAGFLIHGHAMGANGFAVACCVFTWIVVGYVLISEKVTSAQGAYNIWAILSLDFLMALFWLASLGANAQLRASFNTPVNIESCYNDGSSVSSNHCTISKRAAVADALGLALMSAVAGVSALEWLLFVATLVFHGHTFRLWHQENKKPSADNATVEMKAQGTPMLAAQATGQPAHPQYTDQQQYQSQMYPPHEIHQQQQQAPAYPPQPQQQQQQQPDAYAQQAAAYPPQQQQQQQQQPAPYAAYPDPSQYQQQQQQAYSPHATPVPGQPYYPPQQPQHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SPR3</accession>
    <name>A0AAN6SPR3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">peptidyl-tRNA hydrolase</fullName>
            <ecNumber evidence="1">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_48547</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the PTH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1"/>
    <dbReference type="EMBL" id="MU854451">
        <property type="protein sequence ID" value="KAK4035217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SPR3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:peptidyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1470">
        <property type="entry name" value="Peptidyl-tRNA hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001328">
        <property type="entry name" value="Pept_tRNA_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018171">
        <property type="entry name" value="Pept_tRNA_hydro_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036416">
        <property type="entry name" value="Pept_tRNA_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17224">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17224:SF1">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01195">
        <property type="entry name" value="Pept_tRNA_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53178">
        <property type="entry name" value="Peptidyl-tRNA hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01196">
        <property type="entry name" value="PEPT_TRNA_HYDROL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0820">tRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4035217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="201" mass="21738" checksum="D45E84F8BAC75A9F" modified="2024-10-02" version="1">MSLRRILVISLGNPGEMRNTWHSAGHIVLEALQRTLGRDQPAFAAQRIGRASALASIGTRYSLLQSPAVMNVSGPWVARAYREHLTERGLAPAEVGVVLVHDDLEEELGVVKVRDWKRSHRGHNGIKSVNGALQADPAGKWARVSVGIGRPDARDKGAVSDFVLSKVPRNARNVLEGSGSQGLFDALAELETRWGGANSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SPS0</accession>
    <name>A0AAN6SPS0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fungal calcium binding protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_47866</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854426">
        <property type="protein sequence ID" value="KAK4038539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SPS0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042971825" description="Fungal calcium binding protein domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4038539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="111" mass="11743" checksum="B6FEFF31F419D2E9" modified="2024-10-02" version="1">MRFTTATITALTLLAPALALPSGETREFRPLMRDMTPRATFNEAEVFAFAAPAGCSILSCIGVIGEAVCIAEAIEDEDWKGIVKCAKVKELCGCAGCFSALGGFLEKYGLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SQ19</accession>
    <name>A0AAN6SQ19_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_48252</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854440">
        <property type="protein sequence ID" value="KAK4038075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SQ19"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4038075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="302" mass="35333" checksum="22D6D83E59B4E184" modified="2024-10-02" version="1">MARTKQRARRNTKALILTWTRFYLPREQKWPTWSVDHAHVHIGPLAGVEGCRKTSLGRMVENPEQAAYIIEWATLDALNNFQSSPACAEFLRNFPEDDNSPVSIESGSAQKHLTLDDGSSSSPPVLSRFLVLKHIVAAPTSPVEGRVTLTTFMVPRKSDTVFDMWYDNFKSVFHAFVPRGSEFTARHRNFWYKFSAVWFWVLAEDQWVEEKFGKLEQTPEDDQRRTILCHFYLWLPRLAIARVMPPATAWAQERWDIREVPRFYPPDPEFDSEEDPEYEEEQERLKKEYLEFHGFEVDEGSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SR32</accession>
    <name>A0AAN6SR32_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_47308</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854408">
        <property type="protein sequence ID" value="KAK4039170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SR32"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4039170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="182" mass="19968" checksum="C6292D97264D2467" modified="2024-10-02" version="1">MPLKAGSSHSSASSLFLSVFRLITNPSTIRHPSTRPYSKQPAFTLFSPHIDPMTRSHKFNDKDHAGLADGTVLPQDTLPKYFAKSGFADADPKKTKKNGGGRANWGNVGDEVVDQDFNFTNARRRSNSSSVGSLDTFKTKFEVNEPEPVFEENMGPEDEEGKTESPSSASSVDENKSSHKEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2025-10-08" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SR73</accession>
    <name>A0AAN6SR73_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Histone deacetylase interacting domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_16015</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854385">
        <property type="protein sequence ID" value="KAK4040069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033698">
        <property type="term" value="C:Rpd3L complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1160.11:FF:000001">
        <property type="entry name" value="Paired amphipathic helix protein Sin3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1160.11:FF:000003">
        <property type="entry name" value="Paired amphipathic helix SIN3-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1160.11">
        <property type="entry name" value="Paired amphipathic helix"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013194">
        <property type="entry name" value="HDAC_interact_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003822">
        <property type="entry name" value="PAH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036600">
        <property type="entry name" value="PAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039774">
        <property type="entry name" value="Sin3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031693">
        <property type="entry name" value="Sin3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12346:SF0">
        <property type="entry name" value="SIN3A, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12346">
        <property type="entry name" value="SIN3B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02671">
        <property type="entry name" value="PAH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08295">
        <property type="entry name" value="Sin3_corepress"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16879">
        <property type="entry name" value="Sin3a_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00761">
        <property type="entry name" value="HDAC_interact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47762">
        <property type="entry name" value="PAH2 domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51477">
        <property type="entry name" value="PAH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042907516" description="Histone deacetylase interacting domain-containing protein" evidence="7">
        <location>
            <begin position="18"/>
            <end position="1792"/>
        </location>
    </feature>
    <feature type="domain" description="Histone deacetylase interacting" evidence="8">
        <location>
            <begin position="1006"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="26"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="240"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="309"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="385"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="609"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="795"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1296"/>
            <end position="1383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="45"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="248"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="309"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="389"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="420"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="454"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="614"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="673"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="690"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="859"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1296"/>
            <end position="1307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1362"/>
            <end position="1371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4040069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1792" mass="197616" checksum="445F8D195F4FA6E2" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SRF7</accession>
    <name>A0AAN6SRF7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SMP-30/Gluconolactonase/LRE-like region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_36621</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854401">
        <property type="protein sequence ID" value="KAK4039411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SRF7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052998">
        <property type="entry name" value="Hetero-Diels-Alderase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42060:SF1">
        <property type="entry name" value="NHL REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42060">
        <property type="entry name" value="NHL REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4039411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="282" mass="28998" checksum="778F3490DA4FC814" modified="2024-10-02" version="1">MLLLLPFLASLASGALIPRQSATQVVRLSSVENVAVRSNGQILATNMNSANLYAIDAVAKTSTTALSVSGASGLSGIGEYAPDLFAVIGGKGIYKVDFTSTPPKSSLIKTITEANNLNGLAVFDNSSVLVADAGKGAVYKFDVNTGAYAVVLQDATMAPSGGIPFGIDGIKYRDGTVWYTNIFKNSFHKVAVDPATAKATGAYTTLWTNLMGDDLCFGPNGKIYVATNSRNSLVEVDPAAGQPTSVGSVTGSTSCAFGRGESDKNVAYVGAGQGVFAVTVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SRN0</accession>
    <name>A0AAN6SRN0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_35929</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854385">
        <property type="protein sequence ID" value="KAK4040057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SRN0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042987091" evidence="2">
        <location>
            <begin position="23"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="93"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="128"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="148"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4040057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="228" mass="24210" checksum="8E78F667A59D5CCC" modified="2024-10-02" version="1">MHYAAVMPLFSSVLLLGGLAAAVPVVNVDEKCVSRTICVDAINPCGIKYGGCYDVCDTSAKPVAPPCPTTTGKPPVPSTTMKVTTKVTTTVITLPTPTKKSTKKPTPTSTKETTTKNPHPTTTRKPHPTTTTKKPTVTKPDKPPVTPTPTKKFTTTTTTKRASTTTSKCNTNVSVCWDGINECGMMYGGCFPDCKPWPTFTAPPCPTKGLPPVITRVTTLPVLTVPYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SRN3</accession>
    <name>A0AAN6SRN3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alpha-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">C8A01DRAFT_46557</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing (1-&gt;4)-linked alpha-D-glucose residues with release of alpha-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.20"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.20" evidence="3"/>
    <dbReference type="EMBL" id="MU854385">
        <property type="protein sequence ID" value="KAK4040072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SRN3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004558">
        <property type="term" value="F:alpha-1,4-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06602">
        <property type="entry name" value="GH31_MGAM_SI_GAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1760:FF:000005">
        <property type="entry name" value="Putative alpha-glucosidase AgdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000138">
        <property type="entry name" value="Putative alpha-glucosidase AgdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030458">
        <property type="entry name" value="Glyco_hydro_31_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030459">
        <property type="entry name" value="Glyco_hydro_31_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF133">
        <property type="entry name" value="P-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00129">
        <property type="entry name" value="GLYCOSYL_HYDROL_F31_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00707">
        <property type="entry name" value="GLYCOSYL_HYDROL_F31_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 8 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="9">
        <location>
            <begin position="307"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="10">
        <location>
            <begin position="747"/>
            <end position="847"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK4040072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="978" mass="107667" checksum="4FCA08D5F0A4C60F" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SS66</accession>
    <name>A0AAN6SS66_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Trafficking protein particle complex subunit BET3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_35849</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Golgi apparatus</location>
            <location evidence="1 8">cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854383">
        <property type="protein sequence ID" value="KAK4040161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SS66"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14942">
        <property type="entry name" value="TRAPPC3_bet3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1380.20:FF:000001">
        <property type="entry name" value="Trafficking protein particle complex subunit BET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016721">
        <property type="entry name" value="Bet3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13048">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018293">
        <property type="entry name" value="TRAPP_I_complex_Bet3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7 8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR018293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4040161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="192" mass="21925" checksum="E9D909762BB9781A" modified="2024-10-02" version="1">MASSKASRLGEEVWKTRMDKVNAELVVLTYGTIVAQLCKDFDSDYVEVNKQLDKMGYNIGLRLIEDYLAKSNTVRRCSNFRETAEMIAKVGFKIFLNITPTITNWTSDGKQFSLVFDENPFADFVELPDDGRAQDELWYSNILCGVLRGALEMVQMQVEAHFVSDVLRGNDTTEMRVSLIRYIDDELPPEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SSL3</accession>
    <name>A0AAN6SSL3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_14652</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854354">
        <property type="protein sequence ID" value="KAK4041599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SSL3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="48"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4041599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="381" mass="43058" checksum="6D782CB39BDBDE3A" modified="2024-10-02" version="1">MLVSRQLSGTAPSLDSEPYRTVPILNHRSTFLALMISFMVLSWICSLLRLYARFFVLHAPGWDDVFITLTMVLILSPAQNLGLGKSVYTMTSPELQQFLRVLYIGSATYPLSATLIKLALLFQYLRIFEAGSRYTVFCKCMIVITIAWGTAFITLRWIPCYPVAAYWDFSIKDARCWGFGSRDPLAYKRVFMAQAISTAVLDFIIFAIPTRLYFKPVTQRKTRLCLLGLFTLGLLAILCAMLRMAFVIKHFTPAATFRFDPAWYSPTTDGLACLEVHLAAICAALPVFWPLVETKWGRVFVTTEVSVTREVGQFRPYIELHSASFHRNPTLDQSHELQRPETWQPFVGDETTGLGESATVIEAPVATKRSGKVREVFGLRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SSM0</accession>
    <name>A0AAN6SSM0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_34353</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854354">
        <property type="protein sequence ID" value="KAK4041629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SSM0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051911">
        <property type="entry name" value="SDR_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976:SF16">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4041629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="176" mass="18975" checksum="093F6EF124395785" modified="2024-10-02" version="1">MVKTQFDINVFGILRTIRAFLPHLRTQPPVSNIPPTILNISSIGGLHGYPSNSVYCATKFALEGLTQALAAEIAPFGMHAAVVEPGNFRTSFLSGTVSAGTANLAPALQVYEDTVAHKARAAFAEFDGRQLGDPVEEAKRIWEYAAGEGMFVGKGRRLRLPLGSDTGKVMRELSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6STF1</accession>
    <name>A0AAN6STF1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_14675</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854354">
        <property type="protein sequence ID" value="KAK4041645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6STF1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF26">
        <property type="entry name" value="AXIAL BUDDING PATTERN PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="180"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="275"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="336"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="186"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="284"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4041645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="393" mass="41356" checksum="694CE81BBBCD1342" modified="2024-10-02" version="1">MAFTNQDRTILGPLTTVFTAPAACTVAHGFCQSCDVAWWGQTCAETTVQDNTDCWPTTTAGAPEVTELPLYGRGFYSPGLECPAGHTSACSAVDGVTSQWKVQFQMEAQETFVGCCPTGFKCDNLKGQTCLMRAKSTTLPTVSCISGSSNNFGFMTFPNSKVTTLNLYAPMIQLAWKASDRPENWTPPTTTSDSSTISGSRATSAPTTSLPSSTSTTDPFTPVNEPGTFASVAADSASPLSTGAIAGIAVGAAALFLLILAAIIFVWRRRRRHSSALRGGGQDPSNSASNPPSYSELGGSSPSMEDAKHYYAGNVAEMGQGHERAEVAGDEHGAVEAPTQGHDRAEMFAGEWQQGQGRTEQVPVRGGVSPPSPPPPGYFPGQAPVEMPTEKYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6STR7</accession>
    <name>A0AAN6STR7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Luciferase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_45038</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the NtaA/SnaA/DszA monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854350">
        <property type="protein sequence ID" value="KAK4041826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6STR7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="entry name" value="Luciferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051260">
        <property type="entry name" value="Diverse_substr_monoxygenases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016215">
        <property type="entry name" value="NTA_MOA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03860">
        <property type="entry name" value="FMN_nitrolo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30011">
        <property type="entry name" value="ALKANESULFONATE MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30011:SF16">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000337">
        <property type="entry name" value="NTA_MOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="Bacterial luciferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Luciferase-like" evidence="6">
        <location>
            <begin position="31"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4041826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="466" mass="50942" checksum="E25EC15885F6DB10" modified="2024-10-02" version="1">MTTKKQLIINAFVESCSGHQSPGLWAHPDDQSSNFNDVKHWVKLAKLLEAGKFHGIFIADVLGAYDVYKGPRNPDPAVVSGAQWPVNEPLAVVSAMAAATESLGFGVTVATTYEQPYHLARRLSTVDHLSGGRIGWNVVTGYLDSAARNLGHTEQPPHDERYAIAEEYIDVMYKLWQSSWRDDAVKLDREKRIYTDPKLVRPIDHAGKYYTVPGPHICQPSPQRTPLILQAGTSKAGKAFAAQHAEAIFVAGHSPSVVAKNVADIRAAARDEYGRDPASIKFLALFCPIIGATAEEARAKYEEYLSYGSEDGALALFGGWTGIDLAQYGDDEELRHVESNAIRSAVEAWSKSVPGIPKWTKHTVANHIKVGGLGATAVGTAEQVADEMERWVADADVDGFNLAYALMPGTFSEVVEHLLPVLRSRGLFWDGYTVPGGTYRENIYGKPGLARPPADHPAAKYHWKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SU32</accession>
    <name>A0AAN6SU32_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_14184</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854345">
        <property type="protein sequence ID" value="KAK4042171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SU32"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4042171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="88" mass="9936" checksum="7F9B5653A900E8AB" modified="2024-10-02" version="1">MEVCYCANYYILKSGTSLTPGRLPDDCLWLASQSRSHEERDDHSERSSFSTSRRPSWPFRGLSLASSSKKPTSDAGIWWNGKTSFRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SUK3</accession>
    <name>A0AAN6SUK3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_32773</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAK4043132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="KH-I_ScSCP160_rpt4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="8"/>
    </dbReference>
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        <property type="entry name" value="KH_dom"/>
    </dbReference>
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        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
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        <property type="entry name" value="SCP160-like_KH"/>
    </dbReference>
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        <property type="entry name" value="DODECA-SATELLITE-BINDING PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10627">
        <property type="entry name" value="SCP160"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="8"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="KH"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="5">
        <location>
            <begin position="131"/>
            <end position="209"/>
        </location>
    </feature>
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            <end position="370"/>
        </location>
    </feature>
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        <location>
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            <end position="682"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="5">
        <location>
            <begin position="686"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="5">
        <location>
            <begin position="782"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="5">
        <location>
            <begin position="857"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="5">
        <location>
            <begin position="938"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="5">
        <location>
            <begin position="1007"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="5">
        <location>
            <begin position="1122"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="731"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="524"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="1098"/>
            <end position="1125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK4043132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1201" mass="131866" checksum="E947C3032DE8191E" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SUR6</accession>
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        <submittedName>
            <fullName evidence="4">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
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    </protein>
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        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854328">
        <property type="protein sequence ID" value="KAK4043342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:mitochondrial translational elongation"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Helicase_Restrict-Modif_Enz"/>
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        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="entry name" value="ATP-DEPENDENT HELICASE IRC3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </feature>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="669" mass="73406" checksum="C83A802F3192A057" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SV23</accession>
    <name>A0AAN6SV23_9PEZI</name>
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        <recommendedName>
            <fullName evidence="4">Glyoxalase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">C8A01DRAFT_32649</name>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854329">
        <property type="protein sequence ID" value="KAK4043325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SV23"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4043325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="95" mass="10097" checksum="26E321928C4F625D" modified="2024-10-02" version="1">MVDWRSPKFGAPAWLGISANDVSRVETFYAAVFEWTFRDAPTNDIQPDHPKTHLFNLTPSGVALSGGLQHQPETSRTGTPAAGTGGTFSTGCTCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SV79</accession>
    <name>A0AAN6SV79_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycerophosphocholine acyltransferase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">C8A01DRAFT_32419</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GPC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854327">
        <property type="protein sequence ID" value="KAK4043490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SV79"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006656">
        <property type="term" value="P:phosphatidylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021261">
        <property type="entry name" value="GPCAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31201:SF1">
        <property type="entry name" value="GLYCEROPHOSPHOCHOLINE ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31201">
        <property type="entry name" value="OS01G0585100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10998">
        <property type="entry name" value="DUF2838"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="179"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="334"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="426"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="472"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="539"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="47"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="61"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="547"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK4043490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="564" mass="63275" checksum="4C6114768C3F7734" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SVH6</accession>
    <name>A0AAN6SVH6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_32094</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854324">
        <property type="protein sequence ID" value="KAK4043775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SVH6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4043775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="85" mass="9067" checksum="ECF5A8CF81FA8F3A" modified="2024-10-02" version="1">MGAVVSCEMIQIQSCFRTIGRTIMAIINGIGGIIMAIVNGIVNFLDIIVGCLTCNTCGGRRRHSRGATHGTTTGRRRGFGRRSAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SVK8</accession>
    <name>A0AAN6SVK8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Flavin-nucleotide-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_12310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854320">
        <property type="protein sequence ID" value="KAK4044212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SVK8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024747">
        <property type="entry name" value="Pyridox_Oxase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34071">
        <property type="entry name" value="5-NITROIMIDAZOLE ANTIBIOTICS RESISTANCE PROTEIN, NIMA-FAMILY-RELATED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34071:SF2">
        <property type="entry name" value="FLAVIN-NUCLEOTIDE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12900">
        <property type="entry name" value="Pyridox_ox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4044212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="274" mass="30040" checksum="CF56A0251443FC1C" modified="2024-10-02" version="1">MPLRELQYPTEPYSKVNRMKDRADYALETIHQIVNSCPMLHVSFQSPNSPFPVVLPMIGQMGSFSRPSADLGDVLDLYLHGYVSSRLMNTTRSADAQEEEKEKEKGLPMTIAASHVDGLVLALTPNSHSYNYRSAILFGHATLVTDTAEKLYAMELITNSVVPQRWTNSRVPPNAAEMQSTSVLKVTISTGSAKIRTGGPHDEKGDLEDEALLGRVWTGVVPVYSVMGEPVAGGYNRVGEVPGYIEGWRGEVNKDAEEYAREAVGREVGEKGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SW65</accession>
    <name>A0AAN6SW65_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_42981</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854320">
        <property type="protein sequence ID" value="KAK4044318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SW65"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24216:SF65">
        <property type="entry name" value="PAXILLIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24216">
        <property type="entry name" value="PAXILLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
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            <end position="325"/>
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            <end position="797"/>
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    </feature>
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            <begin position="599"/>
            <end position="642"/>
        </location>
    </feature>
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            <begin position="89"/>
            <end position="99"/>
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            <end position="156"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
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            <begin position="182"/>
            <end position="197"/>
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            <end position="282"/>
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    </feature>
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            <begin position="349"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="676"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="703"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
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            <begin position="728"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="776"/>
            <end position="786"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4044318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="797" mass="88715" checksum="E01FABE49DA99C11" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SW94</accession>
    <name>A0AAN6SW94_9PEZI</name>
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        <recommendedName>
            <fullName evidence="4">Cysteine-rich transmembrane CYSTM domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">C8A01DRAFT_31374</name>
    </gene>
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        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854318">
        <property type="protein sequence ID" value="KAK4044585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK4044585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="93" mass="9986" checksum="85288EBD0495E7E6" modified="2024-10-02" version="1">MSAQDYYQQGPPHGYGSPAPYPQHPQPTYPGTAPQQGYYPPQGQMQYQEQPRQKSGGGGGCLKGCLAALCCCFVCEEGCECCAECCECCVECC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SWE8</accession>
    <name>A0AAN6SWE8_9PEZI</name>
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        <recommendedName>
            <fullName evidence="8">Drebrin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_12048</name>
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        <name type="scientific">Parachaetomium inaequale</name>
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        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854318">
        <property type="protein sequence ID" value="KAK4044586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="term" value="C:actin filament"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:actin filament binding"/>
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        <property type="term" value="P:regulation of actin filament polymerization"/>
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        <property type="entry name" value="Actin binding protein"/>
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    </dbReference>
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        <property type="entry name" value="Actin binding protein"/>
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        <property type="entry name" value="Actin binding protein, putative"/>
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        <property type="entry name" value="Severin"/>
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        <property type="entry name" value="Abp1_fungi_SH3_C1"/>
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        <property type="entry name" value="ADF-H"/>
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        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
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        <property type="entry name" value="SH3-like_dom_sf"/>
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        <property type="entry name" value="SH3_domain"/>
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        <property type="entry name" value="CORTACTIN AND DREBRIN"/>
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    </dbReference>
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        <property type="entry name" value="DREBRIN-LIKE PROTEIN"/>
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    </dbReference>
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        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
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        <location>
            <begin position="5"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
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            <end position="700"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="3">
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        <location>
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        <location>
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        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4044586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="783" mass="82029" checksum="28BFB5565B5FF61F" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P534</accession>
    <name>A0AAN6P534_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_41635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854677">
        <property type="protein sequence ID" value="KAK4031924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P534"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042968903" evidence="1">
        <location>
            <begin position="19"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4031924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="120" mass="12265" checksum="74A44C886F843D96" modified="2024-10-02" version="1">MKFTLATIFLGIAAVASALPQDPALVARQNQNRPVPRGNCCVANTSLKQDACTAANGQAGRCVPGGNNCGSSLSCIAQSSLTCDNNVIERGKSLCRANAARGGLFDGANIIQNLSQASVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P5I6</accession>
    <name>A0AAN6P5I6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1996 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_50997</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854643">
        <property type="protein sequence ID" value="KAK4032146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P5I6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018535">
        <property type="entry name" value="DUF1996"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662:SF6">
        <property type="entry name" value="DUF1996 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09362">
        <property type="entry name" value="DUF1996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1996" evidence="1">
        <location>
            <begin position="42"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4032146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="360" mass="38776" checksum="22CDD9295FFF5834" modified="2024-10-02" version="1">MLWYALVLTALAEAAPQFGGGGGNRPTMLRFGCSQLVIDRIDPLVNPGQLPSPHMHQVVGGNTFNVSVPTSDIGELASCTTCSYSEDLSNYWTANLYFKARNGSYKRVPQVPNRLLFGDQFTTKTKGGFVVYYVSPGKGGVTAFKPGFRMLVGDANQRQKIGNGRKSQSCFRCYTGPDFAGDNAAPCADARLDTEALPTGQCHGIRSNILYPTCWDGKNLDSPDHKSHVAYPVSGAQTFTGSSVGGNCPSTHPVKIPQIMLEIVWDTSLFNNKAEWPADGSQPFVLSTGDTTGYGQHGDYVFGWKGDSLQRAMDAGCTGASCTGIKTQTVEEANKCAVPGRVKEDFDGWLDHLPGMTMPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P5R3</accession>
    <name>A0AAN6P5R3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_41379</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854638">
        <property type="protein sequence ID" value="KAK4032184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P5R3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="170"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="335"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="421"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4032184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="480" mass="51722" checksum="6381483B98A40FFC" modified="2024-10-02" version="1" fragment="single">MESLRSERDRNASDGSSLTSWAHSGPSTLTSQEQQQWREWEKQRLSVIRENGAHVPSPSIRRRVLGSGLFQPPDGGTENPVAPRPMVDSQRIYSALVKRMQAMNTEVAQGLEDRSEGLDSERSALVDEDGERKSSETPDTIRRVVPEWKTGSPYRRALRKSMQEEQNAWAQQSSAADQDSDTATQLHHASDGGHLPETDSDSAKDLAYSESVYSSDEGERGPTKAVDASKRNSGLDTPAMYRASGHREASTASSIDWKTWLSANIDKFEPPASPSKPSDAEPTLPRAFPTTHFPSLRGHVREPAQTHDDDRDYDNDDTDNEEDDDVFHPPVNRKLTPLTMTTPLTQLQPNVIKPSPLRHSVSIKRLTPPSSNSNSNSYGTGPGMGNLTRLVENESPVRSAPPPPIPPRSKLRPEPLRIVRPPSVGGVSSVLSSPGLTEAVRRQFGGGGVSGNGGGLGGGFGGDGGGGVSLSYGAADGSQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P6N6</accession>
    <name>A0AAN6P6N6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_40895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854586">
        <property type="protein sequence ID" value="KAK4032664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P6N6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4032664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="426" mass="48168" checksum="0F1B2AEDC108255C" modified="2024-10-02" version="1">MDELNDADTFAKTTHREYQEYIEKFWRPRLAVRYNRIREGYFSAIDTYMEDGMASMAELSASIQAEENEHRAERLCREMVFGRKALAQKLARDGIQHFRDKFGIDIPAVLNNVDNPIVIDSDADEVESNAGLDDDEEAADQDRAGGGSHSLSSPNSSQRKRTRNDRPNVLPPRRKRNRPNCLRPPDPVYDFSSVEAEDIRDSTGVRRIRAHDVEGQDFIFPYPAIGPGYFVVRCDRGKFRHQFQQDPLSLFRGRHIMVNHFNRKAPKPPCHERDEAKEYAAEELVRLFGYRVVDEEDNDVDSDWVERSNERLARTVDREKKKNKKNQAKGKQKAPMRPGRAPCSSRKGIPDHALPAWSSSRAVLAATESGAAGPSNTRGLVPVADMDPAGLWAAQQADVGDVNLGRQEEDGDMPPTRVESDIIPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P6V2</accession>
    <name>A0AAN6P6V2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_40840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854581">
        <property type="protein sequence ID" value="KAK4032725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P6V2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="2">
        <location>
            <begin position="36"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="284"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4032725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="306" mass="33276" checksum="7B246C01979DF007" modified="2024-10-02" version="1">MAPSFAGRVVVKPRHEATEEARDAALARSAPHHIELSLFCDASCALQSDWGGISVAYKPWLPGTFSRDERRPIIEAAYPLAALLDIRLGEFMAVAEALEIAAKELRQIHDKPEWVRKVVWVKVFNDNKYNLFVLVKPVLDLIARQSRALLETPGVRVRLSLHWVPGHGHGITLQNRADEIAVSARYNQLALSTLGGNSWRRWEDPVAVALSFEELAAAAVDAARMRPEYRRGTLPTRAPVVPPTVLGPVPPSSSPAAGPRLPTPPLETKQPKARDNAAQKEEMGAPAPAPASDGPSDSTTKEAAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P7V2</accession>
    <name>A0AAN6P7V2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_21418</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854857">
        <property type="protein sequence ID" value="KAK4031341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P7V2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4031341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="88" mass="10017" checksum="E03592CE71626035" modified="2024-10-02" version="1" fragment="single">RNRAIERRAAASAIERDGQEVDIPCERCWNVKPWRHCIIVPSSNKCSGCVRLGKKYSSPNIINACKSYLSSYRFRLIPSSNGEYIGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P7V6</accession>
    <name>A0AAN6P7V6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Actin-related protein 2/3 complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_41119</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Arp2/3 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
            <location evidence="1 6">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ARPC3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854610">
        <property type="protein sequence ID" value="KAK4032437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P7V6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1760.10:FF:000002">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1760.10">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007204">
        <property type="entry name" value="ARPC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036753">
        <property type="entry name" value="ARPC3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12391">
        <property type="entry name" value="ARP2/3 COMPLEX 21 KD SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04062">
        <property type="entry name" value="P21-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016315">
        <property type="entry name" value="ARP2/3_P21-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69060">
        <property type="entry name" value="Arp2/3 complex 21 kDa subunit ARPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR016315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4032437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="192" mass="21822" checksum="DAC941E8045D860B" modified="2024-10-02" version="1">MPAYNSVFNTSEPAPRLVGNFPLFPLRTKIRGPVYPLPFPDPPLPAGESPDPNSESYDILDEVLALFRANTFFRNFEIQGPADRLLVYGIWFVSDCLTKIKPAATLRDATKDVQNLALDLNFAIPGDPAWPLNQMYEAPRDRQDAEVLKQYMSQVRQELATRLLARVYDEGDAKPSKWWLSFTKRKFMGKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P840</accession>
    <name>A0AAN6P840_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta hydrolase family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_42289</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854952">
        <property type="protein sequence ID" value="KAK4031232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P840"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052897">
        <property type="entry name" value="Sec-Metab_Biosynth_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017:SF3">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="290"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="7"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4031232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="317" mass="34377" checksum="19C70A43CE4049BE" modified="2024-10-02" version="1">MPNLPTLVLVHGSWHQASCFNPITKLLQGKHGVKCIAVSLPSTSGNPEATFKDDIDVTQKAIASETSAGRDVVVIAHSYGGMVGNSAIKGFAKPRDAAAPTPTTGHVIGLILIASGCNLPGLAFMDPFFGHPPPSWRVNKETGYAELVVPPRKLFYHDVPADEAEYWVSQLTTQSLKALFEGGEFSYPGWKDVPVWYIGTIEDRGLPVVAQRLGIGMARAMGGVIEHREMQTSHSPFLSQPVETVGIILEAVEAFTGRPVVEDTPTSKPQIKGVTAPAVRLWQPLTWYRFGLPLAFGRLVGGGFLLFGWCWSLFRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P8E6</accession>
    <name>A0AAN6P8E6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dihydrodipicolinate synthase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_20256</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854582">
        <property type="protein sequence ID" value="KAK4032707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P8E6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00408">
        <property type="entry name" value="DHDPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128:SF68">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4032707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="329" mass="35376" checksum="FF7C26E839969377" modified="2024-10-02" version="1">MSPTPLVPPKGVFVPSPTFFHPASASKDALQAPVDTESQINHSVFLAKSGITGITLLGSTGEAVHLSRSERSDLIAAVRKGLDAAGFPDYPLMAGVLTNGELDDTLQWLDDYAKAGAQWGLVLSPGYFGPAVAQDGLVEWYHLVADRSPIPILVYNYPGVTNGVQVLPETYRALARHPNIVGCKMSHGNVSHHIQVSLDPEIDHDQFHVYSGFGNQLGPIVAFGAAGVIDGMAAFYPKTVVRLMELMSTVGITPETQDEIRRLQFAVSQGEEFVMRYGILGIKEAVCRVAGFGNLEGGRLPIRGKLPDGAWDKAKGMFLGEIHKTESSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P8X4</accession>
    <name>A0AAN6P8X4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Endoplasmic reticulum-based factor for assembly of V-ATPase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_40563</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854560">
        <property type="protein sequence ID" value="KAK4032977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P8X4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070072">
        <property type="term" value="P:vacuolar proton-transporting V-type ATPase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021013">
        <property type="entry name" value="ATPase_Vma12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31394">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 199"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31394:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 199"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11712">
        <property type="entry name" value="Vma12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4032977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="263" mass="29018" checksum="D027D3D603E7971F" modified="2024-10-02" version="1">MTPHMVEGLQSLNKAGNPQNAATRLPQGHDEPSLEDPAVGSPVSHAQAVDLWKALQDAGHGEYTLETLLKGSRVYVPPPAPKPEPSDEYKALMARLRREQEQREYERMANPLPPMETFSQRYPNGAAMAQAFAAVNRPGHEADMGDDDVTYSDVHRQLMLILNFVASILGVAATLWIVARWWSTPARLFLTMGGSILVGVAEVAVYSGYVWHLGQAKKKDKTLREVKEVLQTWTVAAENEAVAVGGKASEEDINLQRRQKNPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P8Z4</accession>
    <name>A0AAN6P8Z4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquitin carboxyl-terminal hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_40531</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854558">
        <property type="protein sequence ID" value="KAK4033007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P8Z4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02660">
        <property type="entry name" value="Peptidase_C19D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000127">
        <property type="entry name" value="Ubiquitin C-terminal hydrolase Ubp8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000821">
        <property type="entry name" value="Ubiquitinyl hydrolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF937">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="2">
        <location>
            <begin position="182"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4033007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="522" mass="58751" checksum="B35E8179E72892EC" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P935</accession>
    <name>A0AAN6P935_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_39517</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854499">
        <property type="protein sequence ID" value="KAK4033999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P935"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4033999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="181" mass="20035" checksum="1BF94050427FDF02" modified="2024-10-02" version="1">MCFHRRLVFACSHHAWLGLTRPCELEQSFDRGDVDTGCSARWSHGFDTVRMQAKCPRCTKTQEGHRFRFGIVKDQIAVLKEHLRLIKGASEIKEREWLHMDSAVQDDAKSDGTEEEGADASSSGETGDTSVEGGVECLDEAMEEVRVDPKHETLRLPQIVAARTARAAGVAAVAEQPARSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P951</accession>
    <name>A0AAN6P951_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CYTH-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_49489</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854498">
        <property type="protein sequence ID" value="KAK4034023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P951"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050333">
        <property type="term" value="F:thiamine triphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042357">
        <property type="term" value="P:thiamine diphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.320.10">
        <property type="entry name" value="Hypothetical Protein Pfu-838710-001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033469">
        <property type="entry name" value="CYTH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023577">
        <property type="entry name" value="CYTH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039582">
        <property type="entry name" value="THTPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14586">
        <property type="entry name" value="THIAMINE-TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14586:SF1">
        <property type="entry name" value="THIAMINE-TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01928">
        <property type="entry name" value="CYTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01118">
        <property type="entry name" value="CYTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55154">
        <property type="entry name" value="CYTH-like phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CYTH" evidence="1">
        <location>
            <begin position="38"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4034023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="256" mass="28717" checksum="7BA304DF31F75A7F" modified="2024-10-02" version="1">MAFRATRALLTTLPKLSHPQATPTPLKKTPATKKKTTILEVERKFRRLAVPSLTTTVTTNIKNRYSPAFQSIQPLPTRTIHDIYYDTPHRTLCAAGAWIRRRNGAWEAKLKRGGDFVNSRFEELRGAEEIGACVRAILGDIPVSGAGGSSSPSAFEERDNFGLGTLAEFVTTREAWVVDGEFRVVRDVMDFGHEVGEVELQVEVEEGTMGEGEKGVMMEEMDQKVEGFMKRYKWAWEKGEAVGKLTAYFEMVKRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P9K8</accession>
    <name>A0AAN6P9K8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">pectin lyase</fullName>
            <ecNumber evidence="7">4.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">C8A01DRAFT_18910</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Eliminative cleavage of (1-&gt;4)-alpha-D-galacturonan methyl ester to give oligosaccharides with 4-deoxy-6-O-methyl-alpha-D-galact-4-enuronosyl groups at their non-reducing ends.</text>
            <dbReference type="EC" id="4.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the polysaccharide lyase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.10" evidence="7"/>
    <dbReference type="EMBL" id="MU854487">
        <property type="protein sequence ID" value="KAK4034264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P9K8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030570">
        <property type="term" value="F:pectate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047490">
        <property type="term" value="F:pectin lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000003">
        <property type="entry name" value="Pectin lyase F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002022">
        <property type="entry name" value="Pec_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045032">
        <property type="entry name" value="PEL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31683">
        <property type="entry name" value="PECTATE LYASE 18-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31683:SF16">
        <property type="entry name" value="PECTIN LYASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00544">
        <property type="entry name" value="Pectate_lyase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00656">
        <property type="entry name" value="Amb_all"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 8 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
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</entry>
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
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                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
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                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
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                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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</entry>
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Chen C."/>
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                <person name="Ament-Velasquez S.L."/>
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                <person name="Grigoriev I.V."/>
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                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="ZnF_C2H2-type_TF"/>
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        <property type="entry name" value="Znf_C2H2_sf"/>
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        <property type="entry name" value="Znf_C2H2_type"/>
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        <property type="entry name" value="ZnF_C2H2"/>
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        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
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        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
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        <source>
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        </source>
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</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PA77</accession>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
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                <person name="Yan M."/>
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                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
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                <person name="Powell A.J."/>
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                <person name="Grigoriev I.V."/>
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                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="309" mass="33500" checksum="5AAFCBD97E904690" modified="2024-10-02" version="1">MADPRKTPKRYFVVSSMDMHPSSVKVGSIISNLNHPDNPLSTFTPVIVEGDETTTATNKTTTTISISDNNELTADTCLTVTTADNTVGGFKRSDAWNLGIFATFLQQLIQAAKLSVSGSKASQFKFSAKEITTSRFAPSAKYIRAAVADEEVADFFRRNGRSARLYLIVAVKVARELTVARVEADKGGVDGVLGIDAATIDVTAGLKGGYKGESGFHHKEEYPGPVVFAFEVKQLRLRRNGEVERIDSDKIKGTMLGRPDGEDQEDGELDIVSDEGIDEDMLELFGIERAEGVGEEDGEACEVFTSTED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PAF7</accession>
    <name>A0AAN6PAF7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_39755</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854510">
        <property type="protein sequence ID" value="KAK4033785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PAF7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4033785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="115" mass="13015" checksum="AA5B8F5872C1AC33" modified="2024-10-02" version="1">MCCLPSANLRGDLIKIDDRADRGFYTVQVKLYDSELCYNIVIDLDCSYVDFLQHAAAVATSGTRVQDATKYDLLYEAHNVTSEDDAQNLERLERLTPAMWLELLGSDRGPEDSMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PAJ3</accession>
    <name>A0AAN6PAJ3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_19761</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854541">
        <property type="protein sequence ID" value="KAK4033263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PAJ3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37538">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37538:SF1">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="505"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="813"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="508"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="553"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="608"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="644"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="702"/>
            <end position="717"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4033263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="867" mass="93720" checksum="820E9D673F78D51B" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PAQ7</accession>
    <name>A0AAN6PAQ7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">feruloyl esterase</fullName>
            <ecNumber evidence="2">3.1.1.73</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">C8A01DRAFT_48814</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>feruloyl-polysaccharide + H2O = ferulate + polysaccharide.</text>
            <dbReference type="EC" id="3.1.1.73"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.73" evidence="2"/>
    <dbReference type="EMBL" id="MU854461">
        <property type="protein sequence ID" value="KAK4034929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PAQ7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030600">
        <property type="term" value="F:feruloyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043595">
        <property type="entry name" value="FaeB/C/D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38050:SF2">
        <property type="entry name" value="FERULOYL ESTERASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042931539" description="feruloyl esterase" evidence="10">
        <location>
            <begin position="21"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK4034929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="320" mass="33621" checksum="4FCEB2E2B4C1344C" modified="2024-10-02" version="1">MARRVLIAGLVAALTAVAAACTPDTSGITTGKLMNETLSSGRSYLLFVPSSYSTRSSPAPLILSYHGGNRNASQQAALDLLTSTFFNVEYVVAYPQGINDRWQGVPGVTTNDTAFTASILSALSSKLCLDSSRIFATGKSDGAGFVGDVLACDAVLSRRVAAVAPVSGAFYAPNNTDRGAGCDPYTVVNACNTNSRVDIPVIEFHGGNDTTIPYGGGVRRRACLPYVPHWVQIWAGRDGLGTANSSYNLTADATVYQFGAGAEGGVVTHVFDGGSVGHSWPATIWNDDNEHNGDGPASFNASSVIVEFFQTWSSRGRRAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PAT0</accession>
    <name>A0AAN6PAT0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphotransferase enzyme family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_49587</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854503">
        <property type="protein sequence ID" value="KAK4033922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PAT0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF13">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="2">
        <location>
            <begin position="73"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4033922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="567" mass="64593" checksum="D11D1D981689DC5C" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PB02</accession>
    <name>A0AAN6PB02_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_38525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854458">
        <property type="protein sequence ID" value="KAK4035013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PB02"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40462">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40462:SF1">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4035013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="126" mass="13534" checksum="3DE11C5284AB1205" modified="2024-10-02" version="1">MDFIKKIADQADGNQGQQPHADQKTQQSGSGGILDKLNGLAGGGPEGEKKEDTLDKGIDWVQENVFKQGAQNDESAAEQAKDSMIAKQIREQYKNATGKDFPLKEKENKEQEAKGSGLGGLGGLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PB76</accession>
    <name>A0AAN6PB76_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Clr5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_18946</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854489">
        <property type="protein sequence ID" value="KAK4034220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PB76"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025676">
        <property type="entry name" value="Clr5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38788">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38788:SF3">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14420">
        <property type="entry name" value="Clr5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Clr5" evidence="2">
        <location>
            <begin position="24"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4034220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="501" mass="55363" checksum="86CAA87D954E2C40" modified="2024-10-02" version="1">MVPPRPKEVTFRPGTRSNAPRVRDEAWEKWKPKIVEIFNTTTLAGTMDYMTREHNFSPTKRQYVHRLRGWGIKKYKQGTNSEGPTPNLAPALNGRDLDTASTEEPGPGRDVVPCSPAPPTVIQELPVDNVAAAVLLPHMVATQTPTMRETPVWIPRLDSTDYKARHLGLADMLVRMAEADAAALSVNEGSWATRFVDLLRAHTFDWGVDEGNGLAQVEDAVQDIVEYHEGRDLLIDLTPRGLRLDVPAYILLRSALVRFNLTDDEDKIDVHDVLGQFIAQHLTAKRAPEQMDTDPILDINCIRSCLTWCMTMLDRNPDIPLEVRGIDGDTAADTFTVLCTLWHVWRCHGLPSSSSCHAEATHSNITPSVAWADDAEPQLGLRATQLLSTMVCMIMAAAPQQTMHAAGMPVLERALAGANALSILSTLGSEGLLHRFLHQACTSNWRLVAQSDEERGFPVQQTAVDARMIEPFRQFVAGSLGIHDLPVLEEEAVLCDFVLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PBC4</accession>
    <name>A0AAN6PBC4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ubiquitin-like modifier-activating enzyme ATG7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 12">ATG12-activating enzyme E1 ATG7</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Autophagy-related protein 7</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Ubiquitin-like modifier-activating enzyme atg7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">C8A01DRAFT_50154</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Preautophagosomal structure</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ATG7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854544">
        <property type="protein sequence ID" value="KAK4033231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PBC4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019778">
        <property type="term" value="F:Atg12 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019779">
        <property type="term" value="F:Atg8 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032446">
        <property type="term" value="P:protein modification by small protein conjugation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01486">
        <property type="entry name" value="Apg7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.100:FF:000003">
        <property type="entry name" value="Autophagy ubiquitin-activating enzyme ApgG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.70:FF:000001">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme atg7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000243">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme ATG7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.100">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme ATG7 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.70">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme ATG7 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032197">
        <property type="entry name" value="Atg7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042522">
        <property type="entry name" value="Atg7_N_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042523">
        <property type="entry name" value="Atg7_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019034">
        <property type="entry name" value="UPF0390"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF3">
        <property type="entry name" value="UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME ATG7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16420">
        <property type="entry name" value="ATG7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09495">
        <property type="entry name" value="DUF2462"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0072">Autophagy</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Ubiquitin-like modifier-activating enzyme Atg7 N-terminal" evidence="15">
        <location>
            <begin position="4"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="14">
        <location>
            <begin position="347"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="576"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="676"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="775"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="680"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="730"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="775"/>
            <end position="792"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF16420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK4033231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="798" mass="87658" checksum="3B2F282618E946DE" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PBF1</accession>
    <name>A0AAN6PBF1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">UTP--glucose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="3 7">2.7.7.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_49301</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a central role as a glucosyl donor in cellular metabolic pathways.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>alpha-D-glucose 1-phosphate + UTP + H(+) = UDP-alpha-D-glucose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19889"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.7.7.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the UDPGP type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.9" evidence="3 7"/>
    <dbReference type="EMBL" id="MU854486">
        <property type="protein sequence ID" value="KAK4034282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PBF1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003983">
        <property type="term" value="F:UTP:glucose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006011">
        <property type="term" value="P:UDP-alpha-D-glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00897">
        <property type="entry name" value="UGPase_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.10.10:FF:000001">
        <property type="entry name" value="UTP--glucose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000002">
        <property type="entry name" value="UTP--glucose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002618">
        <property type="entry name" value="UDPGP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016267">
        <property type="entry name" value="UDPGP_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43511">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01704">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000806">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="412"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000806-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000806-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4034282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="523" mass="58159" checksum="6F0E917E85ECAF27" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PCE5</accession>
    <name>A0AAN6PCE5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_19312</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854509">
        <property type="protein sequence ID" value="KAK4033801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PCE5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="3">
        <location>
            <begin position="688"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="141"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="285"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="327"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="733"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="150"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="164"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="187"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="338"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="745"/>
            <end position="765"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4033801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="765" mass="83685" checksum="826472747105998B" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PCW4</accession>
    <name>A0AAN6PCW4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">S-adenosylmethionine synthase</fullName>
            <ecNumber evidence="11">2.5.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">C8A01DRAFT_18143</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the formation of S-adenosylmethionine from methionine and ATP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>L-methionine + ATP + H2O = S-adenosyl-L-methionine + phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21080"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.5.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="11">Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the AdoMet synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.6" evidence="11"/>
    <dbReference type="EMBL" id="MU854453">
        <property type="protein sequence ID" value="KAK4035165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PCW4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004478">
        <property type="term" value="F:methionine adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006555">
        <property type="term" value="P:methionine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18079">
        <property type="entry name" value="S-AdoMet_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000001">
        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000003">
        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000004">
        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00086">
        <property type="entry name" value="S_AdoMet_synth1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022631">
        <property type="entry name" value="ADOMET_SYNTHASE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022630">
        <property type="entry name" value="S-AdoMet_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022629">
        <property type="entry name" value="S-AdoMet_synt_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022628">
        <property type="entry name" value="S-AdoMet_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002133">
        <property type="entry name" value="S-AdoMet_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022636">
        <property type="entry name" value="S-AdoMet_synthetase_sfam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01034">
        <property type="entry name" value="metK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11964">
        <property type="entry name" value="S-ADENOSYLMETHIONINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02773">
        <property type="entry name" value="S-AdoMet_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02772">
        <property type="entry name" value="S-AdoMet_synt_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00438">
        <property type="entry name" value="S-AdoMet_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000497">
        <property type="entry name" value="MAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55973">
        <property type="entry name" value="S-adenosylmethionine synthetase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00376">
        <property type="entry name" value="ADOMET_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00377">
        <property type="entry name" value="ADOMET_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 11" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="9 11" id="KW-0630">Potassium</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S-adenosylmethionine synthetase N-terminal" evidence="13">
        <location>
            <begin position="20"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="S-adenosylmethionine synthetase central" evidence="14">
        <location>
            <begin position="132"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="S-adenosylmethionine synthetase C-terminal" evidence="15">
        <location>
            <begin position="254"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK4035165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="398" mass="43377" checksum="DE4808AA5FC8C759" modified="2024-10-02" version="1">MATNGTNGTNGSKHYNEGTFLFTSESVGEGHPDKIADQVSDAILDACLAEDPLSKVACETATKTGMIMVFGEITTKAKLDYQRVVREAVKGIGYDDSSKGFDYKTLNLLVAIEEQSPDIAQGLHLDDRLENLGAGDQGIMFGYATDETPELFPLTLLFAHKLNAAMSAARRDGSLPWLRPDTKTQVTIEYKHDNGAVVPLRVDTVVVSAQHSEDITTEKLRKEILEKIIKTTIPAKYLDDRTIYHIQPSGLFIIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDFSKVDRSAAYVGRWIAKSLVAAGLARRALVQLSYAIGVAEPLSIYVDTYGTSEKTSDELVKIIRDNFDLRPGVIVRELDLAKPIYLQTAKNGHFGTNQSFSWEKPKSLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PD09</accession>
    <name>A0AAN6PD09_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_19356</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854512">
        <property type="protein sequence ID" value="KAK4033752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PD09"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039915">
        <property type="entry name" value="TACC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024312">
        <property type="entry name" value="TACC_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13924">
        <property type="entry name" value="TRANSFORMING ACIDIC COILED-COIL CONTAINING PROTEIN 1/2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13924:SF10">
        <property type="entry name" value="TRANSFORMING ACIDIC COILED-COIL PROTEIN, ISOFORM K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12709">
        <property type="entry name" value="Fungal_TACC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="256"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="470"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="563"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="658"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="698"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="599"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="147"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="480"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4033752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="831" mass="89801" checksum="EEDC22B2B855D4DB" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PDR5</accession>
    <name>A0AAN6PDR5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_39041</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854478">
        <property type="protein sequence ID" value="KAK4034476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PDR5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042849087" evidence="1">
        <location>
            <begin position="18"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4034476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="113" mass="12089" checksum="3DC8E3AEEA01134B" modified="2024-10-02" version="1">MKFTLPALPLLAALALAAPNTAGTTDIGELTPDVLALMQETTAQAMAGLAAAAPDVVVEKRAGLEHRYNHCSKCSSHGSMICTNCSVVRFSYLCFTQAIKCKFPSAVWFLIER</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PDW2</accession>
    <name>A0AAN6PDW2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_48773</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="MU854460">
        <property type="protein sequence ID" value="KAK4034943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PDW2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008138">
        <property type="term" value="F:protein tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14518">
        <property type="entry name" value="DSP_fungal_YVH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016278">
        <property type="entry name" value="DUSP12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45848:SF4">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45848">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000941">
        <property type="entry name" value="DUSP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="7">
        <location>
            <begin position="4"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="8">
        <location>
            <begin position="94"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="89"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="104"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate" evidence="5">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000941-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4034943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="394" mass="43050" checksum="786C8D4ABBF8F135" modified="2024-10-02" version="1">MALNRINSADELFVGGVFGVNRGRLVQEHHITHILSVIKYSLNRDEDAFRDVEHLSIDIDDMDDQDILVHLPRMVRFINGGLHRDATSGRAISDDQAQTADTIAPSTASSRSSTPGAVLVHCAMGKSRSVTAVIAYLLWKHPQRFGKADPTTTAEQAVAQALQWVRETRPVAEPNDGFMRQLEMWWDMGCPADSDDAVEKEPAYQRWLYKREVEDAARIGRAPDWIRFEDEATKLEGGAKAGEADGGDAGTELRCKKCRRVLATGPFIVPHQGRGNAEQPGCPHFFIEALSWMRPILEEGALDGRLICPNSKCSASIGRYAWQGFKCSCGQWVAPAFSLQNSKVDKVVTGRQNGGAAAIADRMAALGIRMPPGAGRSPIVATSGAGVERCKENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PE46</accession>
    <name>A0AAN6PE46_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_48048</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854432">
        <property type="protein sequence ID" value="KAK4038353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PE46"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4038353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="245" mass="25987" checksum="5D128A2E991D4241" modified="2024-10-02" version="1">MNHSRYVPNPVYSVNPYQQQQYGGMPQQPQMQGMMPQPMSMPPSAYGNPQPGMGQSPMQASMSPNGMWTPNFANGPIIEDLCAPPPPMGMPMTSPPMNGLPQRMAMAPMHPGAMPQVQNVYGIRQPTPHPFAHGMHPGQGPPMQGMPSARVMGTYPPYTGQQHGIGIVYPPRQMGHNAMMARPRLETGFANPVPTGPAGNGAGMGQMTSPNMGGSPGGDGMPPLTPVEEALRGFLSPDMGDLGHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PF05</accession>
    <name>A0AAN6PF05_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_18450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854465">
        <property type="protein sequence ID" value="KAK4034802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PF05"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027796">
        <property type="entry name" value="OTT_1508_deam-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14441">
        <property type="entry name" value="OTT_1508_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="463"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="579"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="463"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="490"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="584"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4034802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="679" mass="75004" checksum="1AF56E733C857AD8" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PFI7</accession>
    <name>A0AAN6PFI7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Lovastatin diketide synthase LovF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">C8A01DRAFT_38421</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854455">
        <property type="protein sequence ID" value="KAK4035087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF46">
        <property type="entry name" value="FUMIGERMIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="9">
        <location>
            <begin position="12"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="10">
        <location>
            <begin position="918"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="2424"/>
            <end position="2500"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="7">
        <location>
            <begin position="918"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="7">
        <location>
            <begin position="1056"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="7">
        <location>
            <position position="950"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="7">
        <location>
            <position position="1117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK4035087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="2513" mass="272471" checksum="C14E5C109EF7E87F" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PFS9</accession>
    <name>A0AAN6PFS9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_36130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854389">
        <property type="protein sequence ID" value="KAK4039902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PFS9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19075">
        <property type="entry name" value="AKR_AKR7A1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF4">
        <property type="entry name" value="NAD(P)-LINKED OXIDOREDUCTASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="13"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4039902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="351" mass="38818" checksum="75AA4B94841941A7" modified="2024-10-02" version="1">MSPLVAQSPTPRVILGLMTFGPDESAGARITDAGEFGRVLDRFQARGYSEVDTARVYVGGKQEAFTRDAGWKDRGLTLATKIAYPAQLGANTYDKVLESMDTSLKELGAECVDILYLHAADRATPFAETLRAINDLHKAGKFVRFGISNFTAFEVAEIVMTCQHNGWVRPTVYQGMYNAITRSIEAELVPACRRYGLDLVVYNPIAGGLFSGKIKSADMVPAEGRYSDTSTTGRLYRDRYFRDTTFRALQVVEQAVEKAGLTMIETALRWVMHHSALKIKAGNDGIIVGVSSIEQLDANLTHLEKGPLPEELVKALDEAWAINKADTTVYWHKELEYAYDTREALFGTVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PG59</accession>
    <name>A0AAN6PG59_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_16525</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854399">
        <property type="protein sequence ID" value="KAK4039508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PG59"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="9"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="37"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="79"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4039508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="603" mass="67216" checksum="042E333118BA41EB" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PGL4</accession>
    <name>A0AAN6PGL4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_17695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854437">
        <property type="protein sequence ID" value="KAK4038170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PGL4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="184"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4038170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="406" mass="41549" checksum="013D505CEF7C441C" modified="2024-10-02" version="1">MAMAEAAAQPHDQPGRPGRRRPFSALMKKLANLKATSSSDGGRHSGSKRSGAKKPQNNPYPQSGRIAVGISPRHSHYSVSSGPSRRLTSVSSLEQADSVRLSSDEQPPPTTGSRSMAPTVSTEHGTCRSIIAPSHGEASLAGTSRTANGRRGGDSTFSSPAPSVRSLTTTLTTIQTVAPNPGGNNTHTTTNQHSHNSNSQVIHFNQPFPTTSPASAIPAHVATTTQGPFNPTTYATATANNLLTDNASILTLASSSKRRRRRSFDTDASVRALAPSSLWGGSRESLPLSVLSATMDGAAGGPTTPGLHRGASAGVAGIGANERTSIYSATGILGTAAASERNSFYAKQGFSGDAASVRSGLLGHGRADSVAGSISGGLAVPAGTSPLASPREGVEEEKEEGGREKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PH54</accession>
    <name>A0AAN6PH54_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">sphinganine-1-phosphate aldolase</fullName>
            <ecNumber evidence="14">4.1.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Sphingosine-1-phosphate aldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">C8A01DRAFT_47328</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 16 17">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the group II decarboxylase family. Sphingosine-1-phosphate lyase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.27" evidence="14"/>
    <dbReference type="EMBL" id="MU854409">
        <property type="protein sequence ID" value="KAK4039121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PH54"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008117">
        <property type="term" value="F:sphinganine-1-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030149">
        <property type="term" value="P:sphingolipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.140.2150:FF:000002">
        <property type="entry name" value="Sphinganine-1-phosphate aldolase Bst1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000020">
        <property type="entry name" value="sphingosine-1-phosphate lyase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050477">
        <property type="entry name" value="GrpII_AminoAcid_Decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42735">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42735:SF6">
        <property type="entry name" value="SPHINGOSINE-1-PHOSPHATE LYASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 17" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 16 17" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="18" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="16">
        <location>
            <position position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00042568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAK4039121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="570" mass="62351" checksum="13A37EB3F1564563" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PHW8</accession>
    <name>A0AAN6PHW8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">GTP-binding protein rhoC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_46318</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854379">
        <property type="protein sequence ID" value="KAK4040335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PHW8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032506">
        <property type="term" value="P:cytokinetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04132">
        <property type="entry name" value="Rho4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000678">
        <property type="entry name" value="Rho GTPase Rho4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0636">Prenylation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4040335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="313" mass="33947" checksum="79F8D927CEE18AA8" modified="2024-10-02" version="1">MASYQYRNSTYMHERTDSSASRRPESQRRDTRGTRSSDGTVSTMMSTSTGRESSGTTMTEGPAYSKKIVVVGDGGCGKTCLLISYSQGYFPEKYVPTVFENYITYPTHPPTGKTVELALWDTAGQEEYDRLRPLSYPETDLIFVCFAIDCPNSLENVMDKWYPEVLHFCPYTPLILVGLKSDLRYKKTCIDMLKTQGLTPVTTEQGLAVAKKMGAQYMECSSKEMKGVEEIFERAILTVVANDRKMLEAEAAASSSSALGHSGGGGGGGLGIGRRGSTAAYLGSKGSGGGITFGSDGVQIPVVKKKKRKCALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PIG3</accession>
    <name>A0AAN6PIG3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Aspartic peptidase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">C8A01DRAFT_16429</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854396">
        <property type="protein sequence ID" value="KAK4039599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PIG3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05474">
        <property type="entry name" value="SAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033876">
        <property type="entry name" value="SAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF65">
        <property type="entry name" value="ASPARTIC-TYPE ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 8" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042962680" evidence="11">
        <location>
            <begin position="19"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="477"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="12">
        <location>
            <begin position="64"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="433"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="437"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="273"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="309"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK4039599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="499" mass="51832" checksum="D839DE11D40A7BB9" modified="2024-10-02" version="1">MLPVIFAASLLAPAVAAAAEPGRIITRGDGIIRSPVRPIAGPGTNLRVRQNEVEVLNQRAGTRYGVEIEVGTPPQKLTLILDTGSPTTWINPVCATSNLPSDCAQFAQFDYEKSSSLNVTDYVDVLRYGIGNATVQYVYETVSIGSATIENQLIGIAVESHRIPLGILGVSPPIHGQNEYPYILDTMVDQGLIKSRAFSVDLRGVDNPTGALIFGGIDTGKYIGTLAKLPIIPQAKTPSGADRYYITMTGVGLTLPDGSIVQSEELAVPVFLDTGATLSHLPTQIYQALAASFPDAQYDPTSGFYILPCDYTDMAGSIDFYFAGKTIRVPLNDFIWENGPYCILGVTPEDTEPILGDTFLRAAYVVYDQDNRNLHLAQAANCGTNLVAIGEGEDAVPSSTGRCTALPTPTGKGNSLDVTATRPPANTFTGTLPSAGIDGGPGPAQGGTGPTSVTGAGLVPTGNAGSTGSPNAAGRGVAVGGGAAVAAALGVVNVFAWML</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PIQ5</accession>
    <name>A0AAN6PIQ5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_35131</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854368">
        <property type="protein sequence ID" value="KAK4040858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PIQ5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4040858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="56" mass="6021" checksum="BA862E637FE36B0B" modified="2024-10-02" version="1">MDIRLGDVVVSQPDGATGGVVQYDLVKAKSGGERERKDFLNRPPDVLLGADPLQIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PIR7</accession>
    <name>A0AAN6PIR7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">cAMP-dependent protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">C8A01DRAFT_34240</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.11" evidence="1"/>
    <dbReference type="EMBL" id="MU854352">
        <property type="protein sequence ID" value="KAK4041748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PIR7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004691">
        <property type="term" value="F:cAMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd05580">
        <property type="entry name" value="STKc_PKA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000005">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353:SF37">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="60"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="13">
        <location>
            <begin position="332"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="23"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK4041748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="389" mass="44225" checksum="CBFE222147F9D835" modified="2024-10-02" version="1">MAATVAHSQAIPPGLHPLQAAALRAASNAQQQQQQSQPPQRDFDDEPFDVASRKLSVSDFVKVRTLGTGTFARVCLVRPSHGTEADRSRVYALKILRKTDVIKLKQIDHVRHERQILSDVRGHPFITEYAGAFSDHDFLYILLDYVPGGELFTYLRKFRRFDEGMARFYAAEIVLILEHLHEQLGGIAYRDMKPENLLLDAEGHIKLVDFGFAKRLGNNESGHPVETYTLCGTPEYLAPEVIHNKGHTTAVDWWALGILIYEFLTGYPPFWHQNPIEIYKQIVEKPVVFPQDPPISDAAKDIIRQFCTVDRSRRLGNISGGAAKVKAHPFFAGVNWDAVYQKRHRGPIIPPVRYPGDAQCFDIYPEEDATKDEYTDELAGRYDEYFKDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PIS3</accession>
    <name>A0AAN6PIS3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Dioxygenase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_46011</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the intradiol ring-cleavage dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854371">
        <property type="protein sequence ID" value="KAK4040725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PIS3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018576">
        <property type="term" value="F:catechol 1,2-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009712">
        <property type="term" value="P:catechol-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03461">
        <property type="entry name" value="1_2-HQD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.130.10">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039390">
        <property type="entry name" value="1_2-HQD/HQD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007535">
        <property type="entry name" value="Catechol_dOase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000627">
        <property type="entry name" value="Intradiol_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015889">
        <property type="entry name" value="Intradiol_dOase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050770">
        <property type="entry name" value="Intradiol_RC_Dioxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33711">
        <property type="entry name" value="DIOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33711:SF7">
        <property type="entry name" value="INTRADIOL RING-CLEAVAGE DIOXYGENASES DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00775">
        <property type="entry name" value="Dioxygenase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04444">
        <property type="entry name" value="Dioxygenase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49482">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catechol dioxygenase N-terminal" evidence="8">
        <location>
            <begin position="47"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Intradiol ring-cleavage dioxygenases" evidence="7">
        <location>
            <begin position="128"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4040725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="344" mass="37948" checksum="1D2A4D38678FDB3B" modified="2024-10-02" version="1">MGESSNHAQAQAQAHAQAQAHAPPALLDLTIDNITPNTVRINSQSADARLTYLMARLVTHLHDFARETRLSTGEWMAAIGFLIGCGQICSDVRNEFILLSDVLGLSLLVDNINHPKPPGGTEGSVLGPFHTHDAPVLPNGASMTSDPAGEPMLAVCTVKDTRGRPIAGVTIDIWETDSSGHYDVQHADRDAPSERCVMVSDEHGRFWFRGLKPVSYPIPHDGPVGRLLQLLNRHCWRPAHVHFMFGKDGWDRLVTALYLRGDPYETSDAVFGVKKSLVIDLDKVDKETAKEYGVEEGIWLLKHDFVLTTQEETEKLRDQLATEALQNLGLNLKLVDHLPVPDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PIV9</accession>
    <name>A0AAN6PIV9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein rds1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_45768</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854366">
        <property type="protein sequence ID" value="KAK4040933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PIV9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039254">
        <property type="entry name" value="Rds1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38705">
        <property type="entry name" value="PROTEIN RDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38705:SF1">
        <property type="entry name" value="PROTEIN RDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13668">
        <property type="entry name" value="Ferritin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042917649" description="Protein rds1" evidence="1">
        <location>
            <begin position="22"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4040933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="470" mass="50961" checksum="FE162204B49B12B8" modified="2024-10-02" version="1">MAPTAGLLAACLLALASNVRSVPVVSEPSTTVFSEPTTLPSPYAISHSNVTSHGPYNGPPATTTGALSTNVLGPSIPPAPPPPQIVEYEADGNLHGDQPMPFTPSGGIGTNGSEPIYKVASDFDYQSLALALYHEWIELDSFHWGLATFSDEEFDAYGIDAEDRHLLQHMADQEIGHASVLANMLGPNAPKQCTYNYPVSNVREFIDFNQKLTRWAEAGVYGFLSHLNSGPAASMLLQSITVEARQQLIFRQFGGQFPMPEWHTPGIPQSWAWTLLAPYISSCPYNQTRLVWQNFPALHILNQPNPARINGADVWNETTGGYANTLSTKGIPAQELCVNATNKTLDCPAAISNNRSIPLSYPGREVFFQWDAPGQLVGPNNSYVTTTNVAEPKFAAWLSQLNVTYTPLLNVSLQDKTAYTIQPNVSTWKGDPAVNGTMFIALTDVDLFVTPYNVTAINPHVAALAVYQAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PJ80</accession>
    <name>A0AAN6PJ80_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcriptional activator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_14369</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854348">
        <property type="protein sequence ID" value="KAK4041994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PJ80"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="389"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4041994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="398" mass="42649" checksum="EFE69B338EE1A484" modified="2024-10-02" version="1">MSSEPSETGKAGIIVAPDDAPPMDKLTHAVLDDLLYNIVHDLLVKVHRDEKIARANTAAIKVEKLAKSTSDGATTDPKPDVEIETDAAIYKDGKVTLKGNPLKSTKEILCPRCHLPRLVHPTDGKGAKKPDPGVIYCKKHPYIQKPGYDIYGQTWVAPGPGRGKKKKDQKLDPNDPSSPAPGAEGSAKDRPANVLSYPSATCPKCKRCILVTRLNNHMGSCIGNNGRNASRAAAQKISNGSNAGSQNNDNTPPGSQKGTPRPGSRAGSPRKRDVDEFDEDVEESDQANPKKKKKTKANALTKKVILKAKSPATNIKKEKAKASSNLNVEQKMDDDAKDSTVEVAPKKQTPKPKGVSPAKKIKLGPAKAQLPSPAGKKGKRDRDMESESSETLSSPPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PJU8</accession>
    <name>A0AAN6PJU8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SART-1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_44704</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNU66/SART1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854343">
        <property type="protein sequence ID" value="KAK4042324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PJU8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000481">
        <property type="term" value="P:maturation of 5S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005011">
        <property type="entry name" value="SNU66/SART1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14152">
        <property type="entry name" value="SQUAMOUS CELL CARCINOMA ANTIGEN RECOGNISED BY CYTOTOXIC T LYMPHOCYTES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14152:SF5">
        <property type="entry name" value="U4_U6.U5 TRI-SNRNP-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03343">
        <property type="entry name" value="SART-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="19"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="279"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="373"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="530"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="609"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="301"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="328"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="382"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="402"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="530"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="619"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="640"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4042324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="667" mass="74761" checksum="0A65F6C726C981B9" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PKN9</accession>
    <name>A0AAN6PKN9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Mak10 subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_44254</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAK10 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic ATPase epsilon family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854336">
        <property type="protein sequence ID" value="KAK4042759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PKN9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031417">
        <property type="term" value="C:NatC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12153">
        <property type="entry name" value="F1-ATPase_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000039">
        <property type="entry name" value="Ubiquinol-cytochrome c reductase core subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1620.20">
        <property type="entry name" value="ATP synthase, F1 complex, epsilon subunit superfamily, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006721">
        <property type="entry name" value="ATP_synth_F1_esu_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036742">
        <property type="entry name" value="ATP_synth_F1_esu_sf_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057983">
        <property type="entry name" value="NAA35-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007244">
        <property type="entry name" value="Naa35_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057982">
        <property type="entry name" value="TPR_NAA35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21373">
        <property type="entry name" value="GLUCOSE REPRESSIBLE PROTEIN MAK10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21373:SF0">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 35, NATC AUXILIARY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04627">
        <property type="entry name" value="ATP-synt_Eps"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04112">
        <property type="entry name" value="Mak10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25789">
        <property type="entry name" value="TPR_NAA35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48690">
        <property type="entry name" value="Epsilon subunit of mitochondrial F1F0-ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="6">
        <location>
            <begin position="48"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="8">
        <location>
            <begin position="189"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="NAA35-like N-terminal" evidence="7">
        <location>
            <begin position="561"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="domain" description="NAA35-like TPR repeats" evidence="9">
        <location>
            <begin position="831"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1053"/>
            <end position="1076"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4042759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1262" mass="137989" checksum="FE33447D4D404167" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PL06</accession>
    <name>A0AAN6PL06_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">U3 small nucleolar ribonucleoprotein protein IMP4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_33198</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854337">
        <property type="protein sequence ID" value="KAK4042672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PL06"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034457">
        <property type="term" value="C:Mpp10 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042134">
        <property type="term" value="F:rRNA primary transcript binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10480:FF:000001">
        <property type="entry name" value="IMP4, U3 small nucleolar ribonucleoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10480">
        <property type="entry name" value="Probable brix-domain ribosomal biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044281">
        <property type="entry name" value="IMP4/RPF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734:SF2">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="2">
        <location>
            <begin position="85"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00040513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4042672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="296" mass="33746" checksum="3BAB6E41E984B83B" modified="2024-10-02" version="1">MIRKQARQRRDYLYRRALLLRDAEVAEKRAKLRSALASGKPLDAEIANDKQLRQDYDYDASRDVAGDDSLDIDDEYSELSGVVDPRVLVTTSRDPSSRLMSFSKEIRLLFPTGIRLNRGNLVLPELVRSAQSERLSDVVLLHEHRGTPTAITISHFPHGPTLMASLHNVVLRADIPRSIKGTVSESYPHLIFDNFNSPLGLRIVKILKHLFPPRDATASKTAGNRVITFVNQDDCIEVRHHVYVRTSYDSVELSEVGPRFTMRPFSITMGTLENKDADTEWHLSQYTRTSRKKNYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PL38</accession>
    <name>A0AAN6PL38_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Phosphatase 2C-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_44226</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854336">
        <property type="protein sequence ID" value="KAK4042732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PL38"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF589">
        <property type="entry name" value="[PYRUVATE DEHYDROGENASE [ACETYL-TRANSFERRING]]-PHOSPHATASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="6">
        <location>
            <begin position="174"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="47"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="232"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="309"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="581"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="76"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="235"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="261"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="316"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="591"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4042732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="610" mass="65994" checksum="9902217B896A3E85" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2025-10-08" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PME0</accession>
    <name>A0AAN6PME0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">C8A01DRAFT_13849</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854339">
        <property type="protein sequence ID" value="KAK4042553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="118"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="197"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
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            <end position="241"/>
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    <feature type="transmembrane region" description="Helical" evidence="11">
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            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="332"/>
            <end position="350"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
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            <end position="783"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="877"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="906"/>
            <end position="926"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="987"/>
            <end position="1009"/>
        </location>
    </feature>
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        <location>
            <begin position="70"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="395"/>
            <end position="693"/>
        </location>
    </feature>
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        <location>
            <begin position="762"/>
            <end position="1050"/>
        </location>
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            <begin position="1085"/>
            <end position="1322"/>
        </location>
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        <location>
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        </location>
    </feature>
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        <location>
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            <end position="487"/>
        </location>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK4042553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1327" mass="145271" checksum="F16B609E087F5637" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PMZ5</accession>
    <name>A0AAN6PMZ5_9PEZI</name>
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        <submittedName>
            <fullName evidence="5">Protein ELYS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_32935</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854333">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
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            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4042990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PNA5</accession>
    <name>A0AAN6PNA5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RPAP1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_44057</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RPAP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854333">
        <property type="protein sequence ID" value="KAK4042988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PNA5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039913">
        <property type="entry name" value="RPAP1/Rba50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013929">
        <property type="entry name" value="RPAP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013930">
        <property type="entry name" value="RPAP1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21483">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21483:SF18">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08620">
        <property type="entry name" value="RPAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08621">
        <property type="entry name" value="RPAP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RPAP1 N-terminal" evidence="4">
        <location>
            <begin position="85"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="RPAP1 C-terminal" evidence="3">
        <location>
            <begin position="300"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="14"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="121"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="56"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="208"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4042988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="440" mass="48043" checksum="0991951C9D7BF1BF" modified="2024-10-02" version="1">MDVTLGILDIKEREVGDIAPPTFPSPAPSTTGFPAHKKRVSAFKQQRQGKSATASPAPPSANRPPIPSRQNDAPRRDAKVDERRGIDQENKAVLDSMSPEEIAEAQKELYNGMDPRFIQMLLRRANLDEPTGPSPFDVAPPESSQDTAPPPPAKPRHVTVEDAPEELPEADPNPPPKRNNSKPKKTVTFDEDAPPPVPPPNLFPVTSTARPKTAPTKPTPDGNPSADAPHNTHFPPPPAVPDLDPSDPDFLETMHKKFFPNLPADPSKLAWMAPLPTPHSAADRESPYYPGQDSLPVSALRFDFTGALLPPRVSRQIPVSKGLHHHGEAPEAAGYTIPELARLARSSVAPQRCLAYQTLGRMLYRLGKGEWGVGAGGRGGEEDDLAFALWRCFKEGRVLESMEEEAGLPEGKGHRSSKAYATEALWLFEKGGWKERWRGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PNB2</accession>
    <name>A0AAN6PNB2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_33633</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854343">
        <property type="protein sequence ID" value="KAK4042284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PNB2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4042284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="142" mass="16080" checksum="9C3BAB966076C992" modified="2024-10-02" version="1">MFPAINNWRRGEPTPQEYFTFRNGLWYPVEAHLGSSTAPAGPETPVTPRAFQFAVLSWNIDFMRPEDDARMSAALKHLQSLVADKPHPSVIMLNEMTKSDLALIKRADWVREGYNISDATTHHWESPTYGKPLFSSPLPPKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PNE2</accession>
    <name>A0AAN6PNE2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SNF2 family N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_42925</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854320">
        <property type="protein sequence ID" value="KAK4044253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PNE2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000053">
        <property type="entry name" value="SNF2 family helicase/ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF14">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042983747" evidence="5">
        <location>
            <begin position="28"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="351"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="958"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="58"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="108"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="154"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="296"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="680"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="781"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="182"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="297"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="307"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="795"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="825"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="890"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="932"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="946"/>
            <end position="955"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4044253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1181" mass="130516" checksum="97566ACD25A87C64" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PNM6</accession>
    <name>A0AAN6PNM6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_42797</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854319">
        <property type="protein sequence ID" value="KAK4044358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PNM6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4044358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="309" mass="34477" checksum="7EEC9C490B03CE3B" modified="2024-10-02" version="1">MGRLPPAEKLPLALRKNVRDDWDNNKADLEKQLSEILGTAWTIDLNPLAIWPYHNDGYAKESLGSCIKAYIDGAIYQIKYIAGKYGDDFKNEVNTICSAHIMTLDLEEASPPRFSYGGCDVQDGKLRLLFVESYLGSNIDYCCQEDSLTKALNAAPSDAPMSYVVRAGIRTDYDPKIGAVRKQIADLLGKPEDAVTLNPNFEASFAKLTSDASVGGDDWQTNLADFTFRYFDALAYQMKYLQVGEDELVREGVLEAVSTNEYAFRIVDALKYDSYCECDVEDGVLYLQCTPGNFGTNIDHVAQKLMDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PNN0</accession>
    <name>A0AAN6PNN0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_12210</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854319">
        <property type="protein sequence ID" value="KAK4044379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PNN0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF48">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G02700)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="307"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="374"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="409"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="442"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="40"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="477"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4044379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="520" mass="57618" checksum="7B49F7D0AB2A084E" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PNZ1</accession>
    <name>A0AAN6PNZ1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aldehyde dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_44364</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5 8">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854338">
        <property type="protein sequence ID" value="KAK4042614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PNZ1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006081">
        <property type="term" value="P:aldehyde metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016117">
        <property type="term" value="P:carotenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07135">
        <property type="entry name" value="ALDH_F14-YMR110C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000025">
        <property type="entry name" value="Aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000004">
        <property type="entry name" value="Aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012394">
        <property type="entry name" value="Aldehyde_DH_NAD(P)"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570:SF11">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036492">
        <property type="entry name" value="ALDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0125">Carotenoid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3 5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="9">
        <location>
            <begin position="15"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="active site" evidence="6 7">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR036492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR036492-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4042614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="533" mass="59036" checksum="93A764F8E48035AB" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PQ90</accession>
    <name>A0AAN6PQ90_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ras-like protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_32920</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854333">
        <property type="protein sequence ID" value="KAK4042976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PQ90"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001856">
        <property type="entry name" value="RAS small monomeric GTPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="240"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="261"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4042976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="294" mass="31453" checksum="9E73A643B8C2D6F7" modified="2024-10-02" version="1">MKPAQHTPSASDASQPPVPISITICGDGGCGKSSITLRLVRSQWTSEYDPTIEDSYSVTRRLDGVVYHLGLTDTAGQEEYRGMWASSNLGADAFLLVYDITSRDSLDALNYFNELIDMEAETRLDNAARARRAGLTNLHMASSSSPGSSVPDALRGGSGQTIAPVKIVAGNKCDLQESRRVPAAVGLDWARKRGCGFMETSARLEVNIEETFALIVRRVVEARKLAEMGVTDAELAANSRGMTKPLTPLPPGDDADEKAAGGAGERGPGVRGPNINGDRVGKGDAGFWKKLRCW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PQX7</accession>
    <name>A0AAN6PQX7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">proline--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Prolyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">C8A01DRAFT_31385</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Pro) + L-proline + ATP = L-prolyl-tRNA(Pro) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:14305"/>
            <dbReference type="Rhea" id="RHEA-COMP:9700"/>
            <dbReference type="Rhea" id="RHEA-COMP:9702"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78532"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.15"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.15" evidence="2"/>
    <dbReference type="EMBL" id="MU854318">
        <property type="protein sequence ID" value="KAK4044595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PQX7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002316">
        <property type="entry name" value="Pro-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050062">
        <property type="entry name" value="Pro-tRNA_synthetase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42753">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME PROTEIN L39/PROLYL-TRNA LIGASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42753:SF2">
        <property type="entry name" value="PROLINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01046">
        <property type="entry name" value="TRNASYNTHPRO"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="10">
        <location>
            <begin position="64"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK4044595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="575" mass="63000" checksum="3C1703ECEB542E05" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PRK5</accession>
    <name>A0AAN6PRK5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 15">Protein disulfide-isomerase</fullName>
            <ecNumber evidence="5 15">5.3.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">C8A01DRAFT_12832</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Participates in the folding of proteins containing disulfide bonds, may be involved in glycosylation, prolyl hydroxylation and triglyceride transfer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
            <dbReference type="EC" id="5.3.4.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="5 15"/>
    <dbReference type="EMBL" id="MU854325">
        <property type="protein sequence ID" value="KAK4043651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PRK5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02995">
        <property type="entry name" value="PDI_a_PDI_a'_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02982">
        <property type="entry name" value="PDI_b'_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02981">
        <property type="entry name" value="PDI_b_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000139">
        <property type="entry name" value="Protein disulfide-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000154">
        <property type="entry name" value="Protein disulfide-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000185">
        <property type="entry name" value="Protein disulfide-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000017">
        <property type="entry name" value="Protein disulfide-isomerase A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005788">
        <property type="entry name" value="PDI_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005792">
        <property type="entry name" value="Prot_disulphide_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01130">
        <property type="entry name" value="ER_PDI_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01126">
        <property type="entry name" value="pdi_dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929">
        <property type="entry name" value="PROTEIN DISULFIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929:SF132">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13848">
        <property type="entry name" value="Thioredoxin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 15" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11 13" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042664434" description="Protein disulfide-isomerase" evidence="15">
        <location>
            <begin position="21"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="17">
        <location>
            <begin position="7"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="17">
        <location>
            <begin position="335"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="474"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="480"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="492"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="13">
        <location>
            <begin position="50"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="13">
        <location>
            <begin position="385"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00039846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR605792-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAK4043651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="507" mass="55146" checksum="4E9BB095511E07BA" modified="2024-10-02" version="1">MHKAQKFALGLLAAAAVATASDVVQLKKDTFDDFVKANDLVLAEFFAPWCGHCKALAPEYEEAATSLKEKNIKVVKVDCTEEADLCQQHGVEGYPTLKVFRGLDNVSPYKGQRKAGAITSYMVKQSLPAVSEVTKDTLEEFKKADKVVIVAYVDAADKASSDVFTEAAEKLRDNYPFGVSTDAALAEAEGVKAPAVVLYKDFDEGKSVFSEKFDAEAIEKFAKTAATPLIGEVGPETYSDYMSAGIPLAYIFAETAEERKEISEKLKPIAEAQRGVVNFGTIDAKSFGAHAGNLNLKTDKFPAFAIQEVAKNQKFPFDQDKEITFEAIKAFVDDFVAGKVEPSIKSEPIPETNDGPVAVVVAKNYNDIVLDDTKDVLIEFYAPWCGHCKALAPKYEELGALYQKSEFKDQVVIAKVDATANDVPDEIQGFPTIKLYPAGDKTNAVTYSGSRTVEDLIKFIAENGKYKASVVEEAEEVEAESAATESATESASETKAEEAKETDHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PRW7</accession>
    <name>A0AAN6PRW7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_32410</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854327">
        <property type="protein sequence ID" value="KAK4043480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PRW7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF4">
        <property type="entry name" value="HYPOTHETICAL CONSERVED PROTEIN (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="32"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="329"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="587"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="335"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="591"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="629"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4043480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="702" mass="78719" checksum="C8DD670F86384F97" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PRX7</accession>
    <name>A0AAN6PRX7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Myosin-like coiled-coil protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_12990</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the taxilin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854327">
        <property type="protein sequence ID" value="KAK4043495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PRX7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026183">
        <property type="entry name" value="Taxilin_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16127:SF13">
        <property type="entry name" value="GH01188P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16127">
        <property type="entry name" value="TAXILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09728">
        <property type="entry name" value="Taxilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="132"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="426"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="275"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="447"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="489"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4043495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="511" mass="58955" checksum="B0DA487AF683DC95" modified="2024-10-02" version="1">MASATVAPRPATPVANGSPNQPTPDAAHANGHPAAGHDNRPAPAPPGAVPGKKGKQKKAAEPTEASKLIAQRISQLELDAAGEKDQEAEIEREVRKANRELHTQTSKMSDIQKIEHLTKRCSDLLSDMKRHERESIKNKKRGDQLQKDKDNSRNELNKTVSLKEKLEKLCRELQKENNKLKNENKTLSDTQVRSQNTWDERYSGLLRRMDDYQEEKDNPRKQVVDMEVEELYVYLFCSLTDPQLTVPRFCQRFKSFIDQYELRELHFHSQMRTKELEVQYNLARYEREKKNYEVELARSRQLNAQVQTFSKTETELRQQLNVYVDKFKQVCPVRPRRSGAQTDARAQVEDTLNNSNDLFMTFRKEMEDMSKKTKRLERENENLKRKHDQVNGNILKMAEERNKNLGEMDELKKKLEKLNGIIKQMQQQGRGIPQGLTGTVENGYAEGELDGDESEYEDDEYDEGEDEEVSDEGDEYDDETEDELHHQPQPQPYGPERPPPAPVAATTNGHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SK21</accession>
    <name>A0AAN6SK21_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_42279</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854939">
        <property type="protein sequence ID" value="KAK4031241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SK21"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4031241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="235" mass="25149" checksum="C8D751E207EB6FD6" modified="2024-10-02" version="1">MEETGGPSQKQMSSSIYAGPAVWYFLLFVLRAFHLLGGILFSLSLDSSMSLVLHGVALLVLAAECGAAHRSITASSSDLRQKRRWTAAHLALYAAALLALAGCLLAPREIDLPPSFPPDFPKIPDSSGMRILYVPDIFAAVCSAAAFFTLPALRVRNWNSLPRDEGLFVGDAIPVAVYADSGYEDEEEAEDDDEGGESRPLAAAFRAQQTGRRGNETDDEGILALVEGGYAGSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SK31</accession>
    <name>A0AAN6SK31_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_21486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854914">
        <property type="protein sequence ID" value="KAK4031271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SK31"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4031271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="69" mass="8165" checksum="C6D2A7D7A02526EA" modified="2024-10-02" version="1">MEDEIARLRQALEEERRRREAAESRASEEQRRREEAERIVELLQLEPYLEACYTLSLAIKVVTDCSLTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SLC4</accession>
    <name>A0AAN6SLC4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_40913</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854588">
        <property type="protein sequence ID" value="KAK4032636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SLC4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2140.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053710">
        <property type="entry name" value="Arylamine_NAT_domain_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4032636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="110" mass="12544" checksum="A5BC4295AB067085" modified="2024-10-02" version="1">MAPRERRMLYGPLPGVAPTTAGANPNWWRMQLREAGEDSGWMDVCCFVEVEWMPVDFQIMAAGLGSLGLGWFTSRVICFRVILEDGAPVGYLMAWQDEVRKWYKGREEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SLN6</accession>
    <name>A0AAN6SLN6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_20039</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854561">
        <property type="protein sequence ID" value="KAK4032966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SLN6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
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            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="45"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4032966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="387" mass="43663" checksum="AA8B66862E734D57" modified="2024-10-02" version="1">MSNVSSVPGVDPSLVASVKAPYITYPTLLGLLWAGTTLSLVVLLLRLTFRLKIFGRVKLDDYLVIFAFAFHLASTITWTVLAGNLYSTPDSDTTPDMAHLLGLLDRASTALHAILASFFCTWTSVWLVKLAFMVFFHGLGRQIRFQRILWWCVLVFIVASYIITLGLMDYRCLTSFGIDVITKCRTQEVIDFQYRTTRVQTTLDIVTDTLIVVVSGNIVWRVKMPWRKKLMLSGICCLTVVMIIVAVVRSALGAPARVPDPTWLLLGNSLEMTLAIVVACAASFRSLYTHTKKMQVQESLVLQQRSQQSKMRMLRLTFATDTMLSEEYSLWEQHASHSSQESQETLWITPPAETFQQKEPVSHRQVIEPNVQNWASQNPPRNWVGPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SM84</accession>
    <name>A0AAN6SM84_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_20173</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854574">
        <property type="protein sequence ID" value="KAK4032804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SM84"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4032804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="177" mass="19172" checksum="4AA3A425F1D638EA" modified="2024-10-02" version="1">MPAISRAVNIITRTIQARETPYFTSPPPFPPFRQPDDTDDGDGVPFRLDPDDLHADDDNSLSGGTIAAIVVSVVVFFVILTGLLAYLTYRRRKARKIEIALKEESVSDTAATVSGALDPPPPYDEVHLDTRHPGEQRWDSRSDVSGISEEEDSDAMGSHATVTDGLAPERHSGSGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SM89</accession>
    <name>A0AAN6SM89_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_49840</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854520">
        <property type="protein sequence ID" value="KAK4033596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SM89"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="408"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="433"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="464"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="528"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="47"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="595"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4033596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="774" mass="85425" checksum="3B7C816A2E1E6058" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SMG0</accession>
    <name>A0AAN6SMG0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chitobiosyldiphosphodolichol beta-mannosyltransferase</fullName>
            <ecNumber evidence="3">2.4.1.142</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">C8A01DRAFT_39708</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Participates in the formation of the lipid-linked precursor oligosaccharide for N-glycosylation. Involved in assembling the dolichol-pyrophosphate-GlcNAc(2)-Man(5) intermediate on the cytoplasmic surface of the ER.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.142" evidence="3"/>
    <dbReference type="EMBL" id="MU854508">
        <property type="protein sequence ID" value="KAK4033821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SMG0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004578">
        <property type="term" value="F:chitobiosyldiphosphodolichol beta-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000162">
        <property type="entry name" value="Beta-1,4-mannosyltransferase (Alg1), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026051">
        <property type="entry name" value="ALG1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13036">
        <property type="entry name" value="BETA1,4 MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13036:SF0">
        <property type="entry name" value="CHITOBIOSYLDIPHOSPHODOLICHOL BETA-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK4033821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="463" mass="50052" checksum="D544EC17E1BF496D" modified="2024-10-02" version="1">MITLLISLILLCLCSLIAVSGYFLLSLSKYGGPPAGSPDGAVSVHVLVLGDIGRSPRMTYHALSIAKHGGNVNLIGYLETSPHPDVVNSANITITPLPTPPRRPPSIPFILFAPCKVLYQVYHLTRLLARTLPPAQWILVQNPPTIPTLAIASLICCLRNTRLIIDWHNYGWTILAGTRGPNHPLVALAKLYECRFGRLGDLHLTVTHAMARQLRSPPYSITQPMLAVHDRPASIFQPLTSPSTRKEILARVLPAPETDLIPSIMEGTTRLLVSSTSWTPDEDFSLLLDALVEYATTTTTTTSTPTPLLAIITGKGPQKALYLSKINQLTKEGRLPNVRIATTFLPFADYAALLACADLGVCLHMSSSGVDLPMKVVDMFGAGLPVAAYAGYESFGELVREGENGRGFETAGELAGILGRLLGGGDAGRGELERLRRGAVEEGRRRWDEEWDGKVGMVMGLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SN24</accession>
    <name>A0AAN6SN24_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ESCRT-II complex subunit VPS25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_39105</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854480">
        <property type="protein sequence ID" value="KAK4034436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SN24"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000814">
        <property type="term" value="C:ESCRT II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000141">
        <property type="entry name" value="vacuolar protein-sorting-associated protein 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.570">
        <property type="entry name" value="Winged helix' DNA-binding domain. Chain C. Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008570">
        <property type="entry name" value="ESCRT-II_cplx_Vps25-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014041">
        <property type="entry name" value="ESCRT-II_cplx_Vps25-sub_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13149">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13149:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN-SORTING-ASSOCIATED PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05871">
        <property type="entry name" value="ESCRT-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="71"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4034436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="238" mass="26277" checksum="E23670B2DC7508F9" modified="2024-10-02" version="1">MSTPPPPSTTTTPLPPSSSTFPFPREYSFPPFFTRQTNLTTHHAQLTKWAALVLAYCRHHRLFKLSLSGNPPTSTTTTTTGILPLTSTTTPAAGNKPDSPRDTRELFHNPHLNRSLSLSDIREVIAFLRKDGRAEYIISPTSNTTDGGGANDNEGGDIVWIYWRTPEEWASLVESWVEGTGQKGTVFTVYELVEGEGTRGSDFHGLDQELLLKALNVLVKRGKAQIFGQEDSLGVKFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SN69</accession>
    <name>A0AAN6SN69_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cyanate hydratase</fullName>
            <shortName evidence="3">Cyanase</shortName>
            <ecNumber evidence="3">4.2.1.104</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Cyanate hydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Cyanate lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cyn1</name>
        <name evidence="5" type="ORF">C8A01DRAFT_49646</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 3">Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>cyanate + hydrogencarbonate + 3 H(+) = NH4(+) + 2 CO2</text>
            <dbReference type="Rhea" id="RHEA:11120"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29195"/>
            <dbReference type="EC" id="4.2.1.104"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cyanase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.104" evidence="3"/>
    <dbReference type="EMBL" id="MU854507">
        <property type="protein sequence ID" value="KAK4033839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SN69"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008824">
        <property type="term" value="F:cyanate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00559">
        <property type="entry name" value="Cyanase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1160.10">
        <property type="entry name" value="Cyanate lyase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00535">
        <property type="entry name" value="Cyanate_hydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008076">
        <property type="entry name" value="Cyanase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003712">
        <property type="entry name" value="Cyanate_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036581">
        <property type="entry name" value="Cyanate_lyase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00673">
        <property type="entry name" value="cynS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34186">
        <property type="entry name" value="CYANATE HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34186:SF2">
        <property type="entry name" value="CYANATE HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02560">
        <property type="entry name" value="Cyanate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13560">
        <property type="entry name" value="HTH_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001263">
        <property type="entry name" value="Cyanate_hydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01693">
        <property type="entry name" value="CYANASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01116">
        <property type="entry name" value="Cyanate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55234">
        <property type="entry name" value="Cyanase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyanate lyase C-terminal" evidence="4">
        <location>
            <begin position="106"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4033839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="179" mass="19828" checksum="B34B5DFBDA3A7637" modified="2024-10-02" version="1">MTDQRARRGSIIAIAEQRQNLASLDSSIIDRLPAYSAALFEAKTQKRLTFEAIAEHLGRSEVAVAALFYGQARASPEDVAKLHQLLGLSPESNLASQMTGFPDRGRAGPMPPVEPLIYRLYEIVQNYGYAFKAVMNEKFGDGIMSAICFNSKVEKEVDETGAAWVVITLKGKWLPFTRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SNK9</accession>
    <name>A0AAN6SNK9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Cytochrome P450-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">C8A01DRAFT_39267</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854487">
        <property type="protein sequence ID" value="KAK4034259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SNK9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902181">
        <property type="term" value="P:verruculogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11061">
        <property type="entry name" value="CYP67-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000063">
        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF237">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ATNE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12 13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 12 13" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="468"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK4034259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="539" mass="60418" checksum="774F7FA67538584B" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SNT0</accession>
    <name>A0AAN6SNT0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_38323</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854451">
        <property type="protein sequence ID" value="KAK4035231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SNT0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.510">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043053323" evidence="7">
        <location>
            <begin position="18"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="181"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="337"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="182"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="388"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4035231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="412" mass="42522" checksum="7C0450766A42BA21" modified="2024-10-02" version="1">MRSQLWLLAASGHAAWADWAFGQALDHPRGEAALLMPRETRASTHDGANGWTPRPTDGPSIELARGRLKAKRQTANTCGWFVDFESEPFLCATTERCATNSDNVVGCTSSGATTNPFFTVCLDYQAVQNGACNSLGPQTGCCMTKSIGECITYLWPGPTVKSMYGCYSTRGVFSMQDTPAISSTTRVTSRRSSSTSTTSTSETSTETTETGTGTTAVPGQTETGAPPPASSSGGSNTGAIVGGVVGGVAGIALIAGAIAFFVIRSRKKNNSNVGGGTAYSAVAPGDPAFPGSPMPPTGYAPSSASPQMSQAGGYYNPSSVGTALQHPETPYLASTTPPVPGAYDPRNSYYDPAKPAGYVPYPGPTPPQGGLYPGAYPPQPQPQPVSELDTSSAPAGHQSNPVEMAVDPPTQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SP21</accession>
    <name>A0AAN6SP21_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BSD domain-containing protein 1-B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_49180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854480">
        <property type="protein sequence ID" value="KAK4034422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SP21"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3970.10">
        <property type="entry name" value="BSD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005607">
        <property type="entry name" value="BSD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035925">
        <property type="entry name" value="BSD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051494">
        <property type="entry name" value="BSD_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16019:SF5">
        <property type="entry name" value="BSD DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16019">
        <property type="entry name" value="SYNAPSE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03909">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00751">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140383">
        <property type="entry name" value="BSD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50858">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BSD" evidence="2">
        <location>
            <begin position="257"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4034422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="422" mass="45640" checksum="5FAC2D4155DAC629" modified="2024-10-02" version="1">MDIAYDHIQESNFPEEHSDSESPSGDKKPAPQASLNADLQDAYRAFSSSPWGARIGGFFGTVVKQGESVYREAQQELSAVGQDATRGLTDLRQSIINHTRNLSLNTSAPAAAESSSDQASREAGDNADTTPTAARDPSAEAALADSETVLSRLRGEAAKRLKDLQKAEDAADEALLRFGSNLRDFFRDAITIAPPSGDEADSQGGGGGGGGTVLFESKDAHGKRVIHTSRFDAQLHVIHTSPESFVKDGTGAEFEAWTKEFDVDKKTADISGDLDKYPELRATMEKLVPDQVAYVDFWKRYYFLRHGIETAEARRRDLLKEESEEESDEEDSDDETEAGPSKPAAAPKRPGSTDSSTTIHPPAAKKGLLKPSEPRKSDEKSQAGSDTSYDVVGATSGVPSQAPNSPRDSRKVDDDSDEEDWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SP45</accession>
    <name>A0AAN6SP45_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_18393</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854462">
        <property type="protein sequence ID" value="KAK4034874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SP45"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38166:SF1">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38166">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4034874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="286" mass="31739" checksum="F8764683136033B3" modified="2024-10-02" version="1">MCYRLRLNDTSRVKQHLGRKHAPEFYCERCRAIFPNEETHRRHHDSQSCTPQPHRFAGITHQQQRRLSRKSRSSLSEAERWFDIWDIVFPGQPRPASPYVDANLSEDLSRFKEFAHTRGLAMIAAEVRSGGLDISPAMEPEAVSALEQTISRGFVSMFETWTAEHGLGPFAQQTAPGPTPLGDHTNLDEARSVTQEPPANAILFADNGTVLFDSIPDGEARLTRAHGEQRHEGRGSCPSALWNGLSGGEADAEFDWGLERYSFFHDATGQVNPVTQGGTAGVGMAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SP75</accession>
    <name>A0AAN6SP75_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_39094</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854480">
        <property type="protein sequence ID" value="KAK4034425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SP75"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42090">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42090:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4034425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="159" mass="16761" checksum="2375114131C3F2AB" modified="2024-10-02" version="1">MSLRTTAQTLLAQARTLRPANLTPATSRPATPAANPTGPLNLTSVRQYRPTADLLSYKDDQDRQSLKPRPSEGTKSGSDDEVAEKTDAAFNPAKTSPEAEKDSAARASNGNPLEASGANQEFSRPPQAAEEVADKEDKKTRSGGTGGKGGKKQGKVKPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2025-10-08" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SP82</accession>
    <name>A0AAN6SP82_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_38871</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854470">
        <property type="protein sequence ID" value="KAK4034662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1421"/>
            <end position="1453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4034662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1859" mass="199966" checksum="C688F50877AC8A30" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SPQ6</accession>
    <name>A0AAN6SPQ6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_47893</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854427">
        <property type="protein sequence ID" value="KAK4038494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SPQ6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043046464" evidence="2">
        <location>
            <begin position="23"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4038494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="262" mass="27598" checksum="93D7606089BCDD72" modified="2024-10-02" version="1">MVHSIRSVALATLLILPYTVTASYYQEVEDGPNVLDECVACPRMYTNLYECQKIAQPGRVGDEVRNCVCVPAYDGWYTYLDSCRGCLPGTGTDDFWGNMGRMMTHLYHTCLSSGNITSDGSVLCASDEKTEDCMALRDSSQGETRVSFRWLDDATGKYDSNRTQLLNLAAVKANLTTSTTVEPAASTTIATGTAATGSDTTASASTTTPATGTGSQVPSGTTGQQRTTTTAAPSFAARLSQGSQAGYVLGMLIVAGIVGGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SQQ1</accession>
    <name>A0AAN6SQQ1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_37400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854423">
        <property type="protein sequence ID" value="KAK4038631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SQQ1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="260"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="173"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="291"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4038631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="400" mass="43878" checksum="EF0302D4FAC5F70B" modified="2024-10-02" version="1">METSPTVANFTTDLLDASPPLGLPVAAASPPRFPPFFALPAGFAVPGPFFFSPVDNMAHSEECTSSRCAVWVGPCKSFIMEVEDDERPEDNEVWEVLPPTMPGTKVAAATEAAEVNTMATSTNGAQAGHTGSKKRLIKRHPFLDDDTSDDDQMLDVIPAPTFNDIDIAEKITKALQQLNIDEVKSDIKNLQDDMARLAFKTNELVSKQECNEFIESKLPAENGAIQRIARQATETELKAHGNNNDSRIAKIEAWMDKSSLHATQSEAARNQSNGHTTASPRPFIPSDNQRITALEAENRKLREALEAEKKDRIELQRTVTQLSETVAGFHKTAEADKKERAEEKKERAELYSIFAGVRCTVTELRLRCQTIHTKLKQLAPATSATTATPAIAATLGPNQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SQT8</accession>
    <name>A0AAN6SQT8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Histidine phosphatase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_47758</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854422">
        <property type="protein sequence ID" value="KAK4038678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SQT8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050278">
        <property type="term" value="F:sedoheptulose-bisphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046390">
        <property type="term" value="P:ribose phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1240:FF:000022">
        <property type="entry name" value="Phosphoglycerate mutase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF15">
        <property type="entry name" value="SEDOHEPTULOSE 1,7-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="23"/>
            <end position="24"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4038678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="255" mass="28508" checksum="B8E50C368B5AFB69" modified="2024-10-02" version="1">MSTPRVFIVRHGETEWSLNGRHTGSTDIPLTANGEKRVLATGKALVGNDRLIVPSKLAHIYVSPRRRAQRTLELLNLAYKDQLPWQAHGEPFCEGRKCEASIEVTEDIREWDYGDYEGITTPHIRELRKQQGLDPNWDIWRDGCPGGESPADISERLDRLIKEIREKWHAPVMSKQAAEGANGDVVIVAHGHILRAFAQRWARQALHNGPTFLLEAGGLGTLSYEHHSIDEPAILLGGAFIVDIPDIAQRDLPEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SQW8</accession>
    <name>A0AAN6SQW8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_47491</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854414">
        <property type="protein sequence ID" value="KAK4038975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SQW8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF51">
        <property type="entry name" value="QUINIDINE RESISTANCE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="263"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="325"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4038975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="363" mass="39325" checksum="7F40BED5DD20E41A" modified="2024-10-02" version="1">MYGAAYGVIADIATIDERGSFVGVLLLMTDFATSLGPVIGGGLTQGFGWRAIFWFLVIFTGSHFVVMLLFFPETQRNIVGNGSIRPKGLIYQTVFSLIRKRREAKDTKVVAVGEKQETEEGVPAKRRLRFPNPLACLPVLANKGSLLVILITAINYAVKAALQTSLDAQCVELYGLNYIQAGLVYLPSGVGGGVGSYGAGKFVDWNYRRTVTRLSKEQGAQYDKKSPEFPLERARLRGVYFLSATTVVGIIGYGLTLKYRWHIAVMLIMQLLTGTATAATFTLCGTLLTDLNMNRSATAQATSNLVRCLSAGGAVAILQPMVENVGPAGCFAIYASIIFLGIPLAWVLQRYGVAWRKGQPMAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SR13</accession>
    <name>A0AAN6SR13_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_36622</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854401">
        <property type="protein sequence ID" value="KAK4039412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SR13"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4039412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="73" mass="8992" checksum="2E2C441C8BEAF1D2" modified="2024-10-02" version="1">MCGWEEVVYRCDPYHNCRQLRRTPYSCTVHRRHVYGTCRFSERRDRHRVSQVFVNDDCPGTQQMWDEYIVYEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SR35</accession>
    <name>A0AAN6SR35_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pentatricopeptide repeat-containing protein-mitochondrial domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_16949</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Regulates mitochondrial small subunit maturation by controlling 15S rRNA 5'-end processing. Localizes to the 5' precursor of the 15S rRNA in a position that is subsequently occupied by mS47 in the mature yeast mtSSU. Uses structure and sequence-specific RNA recognition, binding to a single-stranded region of the precursor and specifically recognizing bases -6 to -1. The exchange of Ccm1 for mS47 is coupled to the irreversible removal of precursor rRNA that is accompanied by conformational changes of the mitoribosomal proteins uS5m and mS26. These conformational changes signal completion of 5'-end rRNA processing through protection of the mature 5'-end of the 15S rRNA and stabilization of mS47. The removal of the 5' precursor together with the dissociation of Ccm1 may be catalyzed by the 5'-3' exoribonuclease Pet127. Involved in the specific removal of group I introns in mitochondrial encoded transcripts.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Binds to mitochondrial small subunit 15S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854412">
        <property type="protein sequence ID" value="KAK4039051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SR35"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057027">
        <property type="entry name" value="TPR_mt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447">
        <property type="entry name" value="OS03G0856100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447:SF17">
        <property type="entry name" value="OS12G0638900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23276">
        <property type="entry name" value="TPR_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Pentatricopeptide repeat-containing protein-mitochondrial" evidence="7">
        <location>
            <begin position="389"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="423"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="31"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="81"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="128"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="138"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF23276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4039051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="651" mass="71481" checksum="9BA9893AFB1AAFB8" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SR45</accession>
    <name>A0AAN6SR45_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PrpF protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_16766</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PrpF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854407">
        <property type="protein sequence ID" value="KAK4039215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SR45"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.10">
        <property type="entry name" value="Diaminopimelate Epimerase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007400">
        <property type="entry name" value="PrpF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43709">
        <property type="entry name" value="ACONITATE ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43709:SF2">
        <property type="entry name" value="DUF453 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G00360)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04303">
        <property type="entry name" value="PrpF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54506">
        <property type="entry name" value="Diaminopimelate epimerase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4039215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="675" mass="72130" checksum="F6195D81E6E0AF58" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SR91</accession>
    <name>A0AAN6SR91_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_47142</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854402">
        <property type="protein sequence ID" value="KAK4039350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SR91"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd12087">
        <property type="entry name" value="TM_EGFR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF30">
        <property type="entry name" value="MID2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="368"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="410"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="529"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="128"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="170"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="205"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="301"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="316"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="410"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4039350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="584" mass="61086" checksum="78233F8BB704FA50" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SRA6</accession>
    <name>A0AAN6SRA6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Uridylate kinase</fullName>
            <shortName evidence="9">UK</shortName>
            <ecNumber evidence="9">2.7.4.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP:UMP phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Deoxycytidylate kinase</fullName>
            <shortName evidence="9">CK</shortName>
            <shortName evidence="9">dCMP kinase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Uridine monophosphate kinase</fullName>
            <shortName evidence="9">UMP kinase</shortName>
            <shortName evidence="9">UMPK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">C8A01DRAFT_47221</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and dUMP as phosphate acceptors, but can also use CMP, dCMP and AMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>UMP + ATP = UDP + ADP</text>
            <dbReference type="Rhea" id="RHEA:24400"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Binds 1 Mg(2+) ion per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
        <text evidence="9">Predominantly cytoplasmic.</text>
    </comment>
    <comment type="domain">
        <text evidence="9">Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.14" evidence="9"/>
    <dbReference type="EMBL" id="MU854405">
        <property type="protein sequence ID" value="KAK4039261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SRA6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019205">
        <property type="term" value="F:nucleobase-containing compound kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016776">
        <property type="term" value="F:phosphotransferase activity, phosphate group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009123">
        <property type="term" value="P:nucleoside monophosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006221">
        <property type="term" value="P:pyrimidine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000315">
        <property type="entry name" value="Adenylate kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03172">
        <property type="entry name" value="Adenylate_kinase_UMP_CMP_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006266">
        <property type="entry name" value="UMP_CMP_kinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01359">
        <property type="entry name" value="UMP_CMP_kin_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6 9" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="NMPbind" evidence="9">
        <location>
            <begin position="158"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="9">
        <location>
            <begin position="254"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="34"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="138"/>
            <end position="143"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="186"/>
            <end position="188"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="217"/>
            <end position="220"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK4039261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="321" mass="35576" checksum="9DEF7D5258958F15" modified="2024-10-02" version="1">MAATASGRQAWRQLLRNTPRGPAPKQQQYRSAFSRQISSTTTQASSRRAVPQSQSPSAFLRQQPLAQRSYSSGSQGKNTPPRSNSNQVKFWPFLIVIALGSGGYMLLVNRRKEMPPTTTTPAFSPTDVTVLFVLGGPGAGKGTQCARLVRDYHFTHLSAGDLLRAEQDRPGSQYGQLIRDCIKDGAIVPLEVTVALLENAMRDAITSSGTKKFLIDGFPRKMDQALKFEEVVCPAKLVLFYDCPEAEMEKRLLERGKTSGRADDNADSIRKRFRTFIETSMPVVDHYEKEDRVVKVDSTSTPDEVYAATQEKLKKALGDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SRB8</accession>
    <name>A0AAN6SRB8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RTA1 like protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_16717</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854405">
        <property type="protein sequence ID" value="KAK4039291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SRB8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF1">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="166"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="210"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="246"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4039291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="299" mass="33386" checksum="FABFD08026172461" modified="2024-10-02" version="1">MYLAVREEAADQPANPFKFYHYDPSKAGAIIVALLFLATTALHFWQLFRARCWFMLPLAIGGIFEFIGYAARCKSGTESPDWTLGPYVTQAMLLLVAPALFAATIYMQLGRIILLLHGESRALIKKKWLTKIFVAGDVLSFVLQGGGGGYQSSGSLEALNNGATVIIVGLFVQLLFFGVFVVVAVAFILSIRRVPTAQSQTHLPIWRRHMFALCAGSLLIMVRSVFRVVEYLQGFDGYLLSHEPYLYVFDAVLMFLVMALFNYIHPSEVAGLIAEEDRQVKMGILPDNGYHARLDSEYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SRI9</accession>
    <name>A0AAN6SRI9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Abnormal eversion of vulva protein 20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">C8A01DRAFT_36070</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">GTP-binding protein that functions in embryogenesis, cytokinesis, germline development and microtubulule cytoskeleton dynamics.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854388">
        <property type="protein sequence ID" value="KAK4039937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SRI9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04154">
        <property type="entry name" value="Arl2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000981">
        <property type="entry name" value="ADP-ribosylation factor-like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045873">
        <property type="entry name" value="Arl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044612">
        <property type="entry name" value="ARL2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45697">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="9 15 17" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0519">Myristate</keyword>
    <keyword evidence="8 15 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="21"/>
            <end position="28"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="125"/>
            <end position="128"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00055307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00077919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAK4039937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="183" mass="20870" checksum="115071CFA3061C21" modified="2024-10-02" version="1">MLSILRKARLKDKELRILMLGLDNAGKTTIVKKIMGEDVNTVSPTLGFIIKTIDYDGYKLNIWDVGGQKTLRSYWRNYFEKTDALIWVVDATDRLRIDDCREELHGLLQEEEKRLSGASLLVFANKTDVAGCMTGDELSGALRLDEIRTHRWSILRCSAMTGENLKEGLAWVVEDAKARLFLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SRV2</accession>
    <name>A0AAN6SRV2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nicotianamine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_35687</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nicotianamine synthase (NAS)-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854380">
        <property type="protein sequence ID" value="KAK4040267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SRV2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030410">
        <property type="term" value="F:nicotianamine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030418">
        <property type="term" value="P:nicotianamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004298">
        <property type="entry name" value="Nicotian_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32266">
        <property type="entry name" value="NICOTIANAMINE SYNTHASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32266:SF12">
        <property type="entry name" value="NICOTIANAMINE SYNTHASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03059">
        <property type="entry name" value="NAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51142">
        <property type="entry name" value="NAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4040267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="328" mass="35922" checksum="8466D13C317588B2" modified="2024-10-02" version="1">MDPCPCASHDSLAIVEKADILRDQRADSRAEKVRWLVQSVVETHSELLKLPHFRPGKAINQLLGNLVSVCSEIHDRDVVDKVLSHTSVQAVLPSLRQICAQAESCLELHWAEHILATEGTPDEVLARLKTFPYYENYEELTRLELCAILSATKTTPRRVAFIGSGPLPLTSLCLLQSLKQDALVTSLSAPADSKKDQEPVILNVDYDSAAIAASLTLSLALGETGRGMEFICAEATSPTKDLAEFDVVYLAALVGISQTEKEGIMLQVVDRMRPGALLVVRSAWGLRTCLYPEVDLATEGLRKRLECCIVVHPYGQVVNSVIVARVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SRY8</accession>
    <name>A0AAN6SRY8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_16220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854390">
        <property type="protein sequence ID" value="KAK4039833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SRY8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2670">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042065">
        <property type="entry name" value="E3_ELL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="121"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="144"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="219"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="433"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="501"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="520"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="532"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="620"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="642"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="666"/>
            <end position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4039833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="766" mass="81988" checksum="0EBBC426742230A6" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SU03</accession>
    <name>A0AAN6SU03_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phospho-2-dehydro-3-deoxyheptonate aldolase</fullName>
            <ecNumber evidence="6">2.5.1.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_44751</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 6">
            <text>D-erythrose 4-phosphate + phosphoenolpyruvate + H2O = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14717"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="2.5.1.54"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Cd(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48775"/>
        </cofactor>
        <text evidence="5">Binds 1 divalent cation per subunit. The enzyme is active with manganese, cobalt or cadmium ions.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the class-II DAHP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.54" evidence="6"/>
    <dbReference type="EMBL" id="MU854344">
        <property type="protein sequence ID" value="KAK4042230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SU03"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002480">
        <property type="entry name" value="DAHP_synth_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21337:SF0">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21337">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE 1, 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01474">
        <property type="entry name" value="DAHP_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="6" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
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        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
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        <location>
            <position position="369"/>
        </location>
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        </ligand>
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        <location>
            <position position="411"/>
        </location>
        <ligand>
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        </ligand>
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        </location>
        <ligand>
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        </ligand>
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        </source>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK4042230.1"/>
        </source>
    </evidence>
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            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="471" mass="52610" checksum="678F1ACE0ED5C6C9" modified="2024-10-02" version="1">MTETTTINGQAPPEWTPESWRSKPIKQCPDYPDKAALAKSVASLHRLPPIVHPREIVQLKQHLRDVAQGKAFLLQGGDCAELFDYCEQGAIESKIKLLLQMSLVLLWGANKRVVRIGRMAGQYAKPRSSPMETVDGRQVPSFRGDILNGFHIDERELDPDRLVKAYHHSSATLNYIRAAISSGIADLSKPLDWGLGHVRDPELKAKYEKAVEFLKDMRSFMHTIGAENEKFHTVDLFTSHEGLLLEYEEPLTRLLDDPTSPPSAPKKDYYNTSAHFLWIGDRTRQLDHAHVEYFRGIANPLGVKVGPSTPASDLLALLRTLNPSREPGKITLITRYGADKVGSLLPAHIRAVEDSEYARTVVWQCDPMHGNTQAVSCGIKTRRFTDIFSELQQTLRIHKEQGSYLGGVHLELTGDPVTECLGGSEGLGEDDLSTNYTSFCDPRLNEKQALELAFLIADHYRTERNGNGGSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SU16</accession>
    <name>A0AAN6SU16_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_13325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854331">
        <property type="protein sequence ID" value="KAK4043099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SU16"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="460"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="516"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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            <end position="107"/>
        </location>
    </feature>
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        <location>
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            <end position="187"/>
        </location>
    </feature>
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        <location>
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            <end position="476"/>
        </location>
    </feature>
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            <end position="553"/>
        </location>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
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            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
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            <end position="600"/>
        </location>
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        <location>
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            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4043099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="682" mass="73778" checksum="6219921B4C2CCDF2" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SU72</accession>
    <name>A0AAN6SU72_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_33497</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854341">
        <property type="protein sequence ID" value="KAK4042425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052973">
        <property type="entry name" value="Fungal_sec-metab_reg_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35392:SF3">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35392">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="97"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="291"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4042425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="809" mass="91477" checksum="90E40A64D711105C" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SUK7</accession>
    <name>A0AAN6SUK7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vezatin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">C8A01DRAFT_43438</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
            <location evidence="2">Adherens junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the vezatin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854325">
        <property type="protein sequence ID" value="KAK4043684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SUK7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017022">
        <property type="term" value="F:myosin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026859">
        <property type="entry name" value="Myosin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026858">
        <property type="entry name" value="Vezatin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15989">
        <property type="entry name" value="VEZATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15989:SF5">
        <property type="entry name" value="VEZATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12632">
        <property type="entry name" value="Vezatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0965">Cell junction</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin-binding" evidence="16">
        <location>
            <begin position="182"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="446"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF12632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAK4043684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="641" mass="71722" checksum="6A5BCDA1D4A7CCE7" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SUN2</accession>
    <name>A0AAN6SUN2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cation efflux protein cytoplasmic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_44094</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854334">
        <property type="protein sequence ID" value="KAK4042875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SUN2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098771">
        <property type="term" value="P:inorganic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1350:FF:000003">
        <property type="entry name" value="Cation diffusion facilitator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000005">
        <property type="entry name" value="Putative Cation diffusion facilitator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="entry name" value="Cation efflux protein, cytoplasmic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050291">
        <property type="entry name" value="CDF_Transporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840:SF12">
        <property type="entry name" value="CATION DIFFUSION FACILITATOR 1 (AFU_ORTHOLOGUE AFUA_1G14440)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840">
        <property type="entry name" value="MITOCHONDRIAL METAL TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="255"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="290"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="333"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="359"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="8">
        <location>
            <begin position="191"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="9">
        <location>
            <begin position="399"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="105"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4042875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="476" mass="52406" checksum="22BCC43584E2C92A" modified="2024-10-02" version="1">MDQPDLSNSISLHPHPFKTQSDSASRLARSPSPNRSMSRGGASTAVEATDGGDDAAVARHPPAMAGDVEVESQRAGRFPLVGAGNDPYGLSQRYKTASELAEIKANTSRKRDAAQQPGPATPAEASTTSKLARYMKPFGRKATTARRLEGFYQAQNETIERLLKSVEEHCAEARQEQGEDHLKFKIAVWGSLVANILLTALQLYAAISSGSLSLFTTMADAIFDPLSNVTLILTNRAVRRVDPARFPSGKARLETVGNIVFCFLMTAVSLIIIAFAARELSEHTGELKPFFLPSIISVCVAFGTKLTLFLYTWSIKDKYSQVRILWQDHRNDLLVNGFGILTSVGGSKLVWWLDPAGAIFLSVVISTLWLRTAFTEFLLLVGVVAPVEIQQLITYVCVTHSPAIRQIDTVRAYHSGPRLIAEVDVVMDPDATLMETHDIAEELQMKLEQLPDVERAYVHVDYETTHKPEHAFKKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SUT7</accession>
    <name>A0AAN6SUT7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Wings apart-like protein regulation of heterochromatin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_33010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WAPL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854334">
        <property type="protein sequence ID" value="KAK4042906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SUT7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039874">
        <property type="entry name" value="WAPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022771">
        <property type="entry name" value="WAPL_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22100">
        <property type="entry name" value="WINGS APART-LIKE PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22100:SF13">
        <property type="entry name" value="WINGS APART-LIKE PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07814">
        <property type="entry name" value="WAPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Wings apart-like protein C-terminal" evidence="3">
        <location>
            <begin position="383"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="160"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="173"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="185"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="202"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="274"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4042906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="849" mass="92579" checksum="2249ADEA609B2911" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SUU9</accession>
    <name>A0AAN6SUU9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_31842</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854322">
        <property type="protein sequence ID" value="KAK4043969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SUU9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39476:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39476">
        <property type="entry name" value="NADH:UBIQUINONE OXIDOREDUCTASE 6.6KD SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4043969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="75" mass="8736" checksum="23ABA40C853A238A" modified="2024-10-02" version="1">MAGLPHNKMAMDPALVRLGNMVQNRYKYFRWTKRTTGITFMYVAVIPAIIGYLGYQTDGLWDLRVKRRGDIISER</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SUW6</accession>
    <name>A0AAN6SUW6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_44154</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854334">
        <property type="protein sequence ID" value="KAK4042938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SUW6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="270"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="407"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="134"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="314"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4042938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="481" mass="49437" checksum="B840FFB1CD13B831" modified="2024-10-02" version="1">MTNQGDASGPSLFQARSTRHNHIHNHNHNLNHQHLHLHQHRRLQPLEADTTSPHIRSPPNEKLHGRQVVIVQTVSVVHYIDATGAVTSVDTLTSDSVAPPTLGLPAVVTAALTAIGDVLPSVSLSGLLPDLTDGAPSSTTSAESETLSSSLSASSETLTSTPLSSSSAFSTLTGVSNSSSTHTPSLFGNSTISLFSNSTRTSSSSRSTFASTSTKSSSSLWTSTADANAPTIAAGGAGTNTDAGASAAVPVPVEPTADAPAGLAPETRNVVVGGVVGSLAGIALIAVALLYLLKWRRQRGQGIMLLGDGDSTARGRGFSSGGSASPSSGRAMAERTGPFAIPSALAMLSGKRAIDAPPSEPPTQEKGFYRVSGKKLVSVLESGGDGYTDPHDSIGSASSYYRHSQAFSDSSNPFQLGSPMRPVSGVPIYHDGAQRTPVQEHGPLPPGHRHSVALPIPDPVGRSFASRDGSRGSGSRFTEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SV30</accession>
    <name>A0AAN6SV30_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_43837</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="MU854330">
        <property type="protein sequence ID" value="KAK4043191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SV30"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033550">
        <property type="term" value="F:MAP kinase tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017017">
        <property type="term" value="F:MAP kinase tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008330">
        <property type="term" value="F:protein tyrosine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043409">
        <property type="term" value="P:negative regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14521">
        <property type="entry name" value="DSP_fungal_SDP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159:SF519">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE MPK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="6">
        <location>
            <begin position="320"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="7">
        <location>
            <begin position="431"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="50"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="133"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="358"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="511"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="846"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="94"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="161"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="571"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="581"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="689"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="720"/>
            <end position="738"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4043191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="870" mass="93382" checksum="7CD4BD7CD67181DB" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SVP8</accession>
    <name>A0AAN6SVP8_9PEZI</name>
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        <recommendedName>
            <fullName evidence="6">CNH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_42449</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854316">
        <property type="protein sequence ID" value="KAK4044839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SVP8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032914">
        <property type="entry name" value="Vam6/VPS39/TRAP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894">
        <property type="entry name" value="CNH DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894:SF27">
        <property type="entry name" value="TRANSFORMING GROWTH FACTOR-BETA RECEPTOR-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="CNH" evidence="6">
        <location>
            <begin position="39"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="252"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="515"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="545"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1036"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="257"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="305"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="523"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1046"/>
            <end position="1060"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4044839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1238" mass="135375" checksum="EE6685BC29D82C1B" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SW82</accession>
    <name>A0AAN6SW82_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_42822</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854319">
        <property type="protein sequence ID" value="KAK4044391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SW82"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="3">
        <location>
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            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="111"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="158"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="251"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="323"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="111"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="176"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="205"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="300"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="325"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4044391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="545" mass="59704" checksum="2860E47AFBA5E5F3" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P4B9</accession>
    <name>A0AAN6P4B9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_42065</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854788">
        <property type="protein sequence ID" value="KAK4031488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P4B9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="295"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="304"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="249"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="356"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4031488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="386" mass="42747" checksum="A6E725DA5930A047" modified="2024-10-02" version="1">MEVDPPQNPNPNPNPAPPAQTRDIRSELAEALSVYPALHAFFESYDGPIKGNDIHLVLPKEVGDKQTTKHFLRVMDWVLEVRDSAFNEAHAQMMSIKEEGEKLVAEEFTTELNKILYTKAMLEGNVYRAVLAGVSKIEEHPNNNQNWPWKIGTEFLAALATKYATHDIVADAENQLTKIAQKDEFAVFNDFLTEFTNLADTANWDNASKVRGFRAKLAPRLSNALTMQVVTPERDDFAGWAEEFRKKLNSTTKGSNGSSGNNGKARDPDTMDLDAIKLASINHKEKERRRTLGLCFKCGQAGHLSRDCQDHGNLSSQSARGGRGGRGSGYQQRGGFGGDYQGHDQGFGRWPEYTMQQSSSGRHQGQSQTAFRGTPARGGYSGRARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P4G5</accession>
    <name>A0AAN6P4G5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_21244</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854763">
        <property type="protein sequence ID" value="KAK4031561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4031561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="437" mass="50403" checksum="655FD1A99DB3F9D2" modified="2024-10-02" version="1">MATANSHRGIVDLPTELIRHICSFLCPVCVQGQRPWSCPECINQRPGCHEWFRGQLDMSRLSRTCKRLRNVVQPTVFLCYPDSGRWQVRRLLRLARTLMQRPDLAQHMRFLMFREPCEELEPWDRKFVHDSIIQLGLPAVPDHWNIDGDPEFRLLPLELVLAHTPDLEYLRVPLDYDWNLHLLSQLVKTRPPFLTKLKSLEVSHYFIAGDRFDVNMDAIDTIIRAAPNLDSLCLPSPNCGYGSATPMPSLRRLYFQDDCSISPEALTALLDAAPKLEVLALRWAAMADSYDDCADRRTTDAWDAVERRRDSLRELRLDIRSDTEQGDGERDSLKDFENFLSALFAPSIREVTFWQPDKEEMSSAMLRFAKVVAVGRYPNLKSVVIAPSEMSGWRELDEALNAEWGESKGELEEDFGKGNVRFELKWESPYWSACRLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P4I2</accession>
    <name>A0AAN6P4I2_9PEZI</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_42024</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
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            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854776">
        <property type="protein sequence ID" value="KAK4031524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P4I2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="151"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="58"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="153"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4031524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="580" mass="63419" checksum="C0C4BDAF01AD7F58" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P4L4</accession>
    <name>A0AAN6P4L4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcription factor sdnS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_51348</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854742">
        <property type="protein sequence ID" value="KAK4031636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P4L4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47840:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47840">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="22"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="149"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4031636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="700" mass="77816" checksum="333C5D0764E92796" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P4N0</accession>
    <name>A0AAN6P4N0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MCM2/3/5 family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_21208</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854750">
        <property type="protein sequence ID" value="KAK4031599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P4N0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054125">
        <property type="entry name" value="MCM5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF42">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21933">
        <property type="entry name" value="MCM5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM AAA-lid" evidence="1">
        <location>
            <begin position="2"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="MCM5 C-terminal" evidence="2">
        <location>
            <begin position="103"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4031599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="165" mass="18428" checksum="6D8B688CE7A57401" modified="2024-10-02" version="1" fragment="single">KRRCAPRLSDAAAEKLSSHFVAIRKQVHAAELEANTRSSIPITVRQLEAIVRITESLAKLTLSPVATEEHVDEAIRLFLCSTMDAVNQGSNQGSRELNEEVSRVEAELKRRLPIGWSTSLATLRREMVEGKGFSEAALNRALMILQRRDTIMFRNQGAQVYRNGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P585</accession>
    <name>A0AAN6P585_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Nnf1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">C8A01DRAFT_20941</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
            <location evidence="2">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854678">
        <property type="protein sequence ID" value="KAK4031914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P585"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000444">
        <property type="term" value="C:MIS12/MIND type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007128">
        <property type="entry name" value="PMF1/Nnf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15459">
        <property type="entry name" value="POLYAMINE-MODULATED FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15459:SF3">
        <property type="entry name" value="POLYAMINE-MODULATED FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03980">
        <property type="entry name" value="Nnf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-0137">Centromere</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="26"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="77"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK4031914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="282" mass="30108" checksum="54A3044A35B8ADC0" modified="2024-10-02" version="1">MPTDRQAPPPAAQPHDADTEMADQPPQAPPPTAAPTPAPQPSPEETEQASPSPDGPPTQEGQGKDQEQQQQQTKQPAPIPPPPPPPGPRAARLQALFASTAKHTLDKINKDNFGACFPTISSKAPGTLEFVQRQMVERLGGLWNREFETIMANRQVVARLNELEDLVNDAARRRMESDHPNSPPVAPHTLPAATILHAHLTPHLATHQSQLNAKLQNTQAANAQLWAEIQAQRAEMEALLAGVEKAVRDMDGASGLLGGGVADELAAETRAAEGDVRAVSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P5Q6</accession>
    <name>A0AAN6P5Q6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_21515</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854944">
        <property type="protein sequence ID" value="KAK4031235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P5Q6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4031235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="63" mass="7155" checksum="03038A4D7ACDFA87" modified="2024-10-02" version="1" fragment="single">SIVLVTPEAAISESFGHFVNRQRAIGRLDWIVVDEYYIVLDSGARGRWRSRILGLRRLAKAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P5U5</accession>
    <name>A0AAN6P5U5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_20727</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854640">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4032170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="154" mass="18268" checksum="1FE585DFC0EB5C01" modified="2024-10-02" version="1" fragment="single">LKPVVKSERENGEAYRERGDRDISAIMDIYENARRRCSNARASRDTLAEYRRTGKRVRTFTGLSPLFLLVYLDKAETVIYALSHISRRDTKRTDNRTLALVATKILQRHPTRFVRFLTRLAEEAEREIRSDRLANMYDIWNIARRKDDGWLREH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAN6P640_9PEZI</name>
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        <submittedName>
            <fullName evidence="3">Protein DJ-1</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">C8A01DRAFT_20478</name>
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        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
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            <taxon>Ascomycota</taxon>
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            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
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    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK4032446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="288" mass="31233" checksum="2BFECAAFC3F0034B" modified="2024-10-02" version="1">MASKTSAVADEPIEVLFALQPKFNLMDFAGPLEVLTSCLHDAQDPTSKAFEATIAGGEPKVLSEQGVIIGSQCSWKEAHERLNDFDVLVILGGNSEEILKEKAEPLSLITAYSELQKNDPSRERTLLSICTGSLFLAKQGILSGLSATTHPDYITKLEILCSEIVIHGLGEHTCVEEDARYVVNNLRFELGDEDENPYIRRKSDARRPSNARKGSMSFKGASRRESIARRAAMRLGGLRVITSGGVAAGIDAALYLVSILVSEDAANEVARLMQVTWTKGVVVDGLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAN6P654_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_41235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854622">
        <property type="protein sequence ID" value="KAK4032335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P654"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046670">
        <property type="entry name" value="DUF6540"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20174">
        <property type="entry name" value="DUF6540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4032335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="178" mass="20198" checksum="11BE9223936A9922" modified="2024-10-02" version="1">MDNNNGLGGRNNHDMTQPNAGMNHPDDDRNDPSFKQERYKVYWVEHVLPPPAQRRSHFIFVNSRFVPMTPGRCGNQGKKFQVTGNISTAAMTFRVQLCDHPRTSDPTCWFEHIGWVLRENFEGRITAFNGTTPLFPGQQLRTCREWTFDVRNQLVGTGVMEPLRALDQGGDPNPVAGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P6D6</accession>
    <name>A0AAN6P6D6_9PEZI</name>
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        <recommendedName>
            <fullName evidence="2">Arrestin C-terminal-like domain-containing protein</fullName>
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    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_50637</name>
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    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
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    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854592">
        <property type="protein sequence ID" value="KAK4032598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P6D6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070086">
        <property type="term" value="P:ubiquitin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF174">
        <property type="entry name" value="ARRESTIN-RELATED TRAFFICKING ADAPTER 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="2">
        <location>
            <begin position="501"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="591"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="725"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="803"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="845"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="906"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="821"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="858"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="971"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="996"/>
            <end position="1021"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4032598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1071" mass="117287" checksum="6DE37AA80BA4FF96" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P6K3</accession>
    <name>A0AAN6P6K3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_40845</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854582">
        <property type="protein sequence ID" value="KAK4032703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P6K3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF2">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ALNH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4032703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="153" mass="17394" checksum="6757BCD946303889" modified="2024-10-02" version="1">MLTLSSFPRWESGSNTDTTTTQGPRTWPILGNLHQIPTKRTHLQFARWAEQYGEIYSLKFGLGTCIVVSSPRLITQLVDKKSNLYSWRPASHLIEPDVSNEKGYCSGFPVCAKDFPRTVTVRSEAWRATILRKSDKARVEVFSLYETPKEKGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P725</accession>
    <name>A0AAN6P725_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_41597</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854669">
        <property type="protein sequence ID" value="KAK4031970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P725"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4031970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="58" mass="6257" checksum="036A14AE51CC3DCF" modified="2024-10-02" version="1" fragment="single">MLRELREVGAAGPLLWIDPATGGSTASTLGLKAWLGISRIEFGIRRFELAGALAVRQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P728</accession>
    <name>A0AAN6P728_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_41526</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854659">
        <property type="protein sequence ID" value="KAK4032032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P728"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4032032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="286" mass="32419" checksum="42083B44967718F9" modified="2024-10-02" version="1">MALLHPSQPYNHWEQDELPFTADGVEYDLLGLVSISYDNGPDSWMWQYAGEPDCAVFITPKLIHELRPCHNPDAMTHFRAYLWARRGNRLKYGRGGRFLVPALDVFFAFLKHDGKTYGFAYTCIGGTCIPVDLAEAAAAAMDAQDTQYATAGLHFAPKHEFINPDGGRSTLVRDIWINIGSGFIIYFTHAWDAAARDFVPMDIPLVETFRGWLRRAVKRVRAGDSVERCFSAGMFLTLDEENGDPMHSHVYDGFEDVEAVQYVPDHNGYYRDEELRVVDAATRLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P757</accession>
    <name>A0AAN6P757_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">WSC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_20002</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854559">
        <property type="protein sequence ID" value="KAK4033004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P757"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057231">
        <property type="entry name" value="DUF7909"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051836">
        <property type="entry name" value="Kremen_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24269">
        <property type="entry name" value="KREMEN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24269:SF16">
        <property type="entry name" value="PROTEIN SLG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25486">
        <property type="entry name" value="DUF7909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042927718" evidence="8">
        <location>
            <begin position="20"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="9">
        <location>
            <begin position="233"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="190"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="190"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4033004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="347" mass="37456" checksum="8920DCB93637F55E" modified="2024-10-02" version="1">MIDWRTVSALLAGAAVSSACTIPTEPLGNNIAYPFRAQVQNATRPEVHNLYMNLLEAGGGDRHLFIGPVGVPTYDLTLVDGVINHVPNGVRAVIGGEIDHTTKLFMTGRGDYRAVFQPTYACNPDTDELQIELHFVTWQNQPTGGHICVRHAFENSHEFRYSPPGNTLIDVDRECIKVTLVVLPTTGLPPQSTTLSTSTIPATPSTSTTSTTPTSTPTGTTPSGAFTDLTAQGYRFLGCAPEERWTTDGPFRTLSGATESSDDMTNQRCAAFCTAQGFKYAGTEWRRECWCGNTVAATRQPATTLASLATCDYKCTGDQAQFCGGDAWLSLYERCEAGAVCENVVFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P7E6</accession>
    <name>A0AAN6P7E6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Pectate lyase</fullName>
            <ecNumber evidence="10">4.2.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">C8A01DRAFT_40520</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Pectinolytic enzyme consist of four classes of enzymes: pectin lyase, polygalacturonase, pectin methylesterase and rhamnogalacturonase. Among pectinolytic enzymes, pectin lyase is the most important in depolymerization of pectin, since it cleaves internal glycosidic bonds of highly methylated pectins. Favors pectate, the anion, over pectin, the methyl ester.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Eliminative cleavage of (1-&gt;4)-alpha-D-galacturonan to give oligosaccharides with 4-deoxy-alpha-D-galact-4-enuronosyl groups at their non-reducing ends.</text>
            <dbReference type="EC" id="4.2.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 10">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the polysaccharide lyase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.2" evidence="10"/>
    <dbReference type="EMBL" id="MU854557">
        <property type="protein sequence ID" value="KAK4033025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P7E6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030570">
        <property type="term" value="F:pectate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004898">
        <property type="entry name" value="Pectate_lyase_PlyH/PlyE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33407">
        <property type="entry name" value="PECTATE LYASE F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33407:SF9">
        <property type="entry name" value="PECTATE LYASE F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03211">
        <property type="entry name" value="Pectate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0106">Calcium</keyword>
    <keyword evidence="8 10 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042663660" description="Pectate lyase" evidence="10">
        <location>
            <begin position="17"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK4033025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="226" mass="23685" checksum="7ED1559A2A39B70E" modified="2024-10-02" version="1">MLVSLALLAAAPTALACLGYEGGVPKATENVPLSAPIYVKAGEVYDGGWRKFDRSPSTCNGQGEGGEKDTAFVVERGGTLRNVIIGKTAGEGVYCKGGGCNLEFLWFEDVCEDAISIKEDRAGDVTNIIGGGAYHASDKVIQHNGCGRVNIINFYANDYGKMYRSCGTCEKCAREVYVEGATARNGGEVVGITKANGDKATLVNVCTDAKTPCQNYSGPGKKDGAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P7E7</accession>
    <name>A0AAN6P7E7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_51268</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854707">
        <property type="protein sequence ID" value="KAK4031763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P7E7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF17">
        <property type="entry name" value="ACETYLTRANSFERASE, GNAT FAMILY FAMILY (AFU_ORTHOLOGUE AFUA_8G05690)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="61"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4031763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="221" mass="24471" checksum="7A8C1A19AC8AED53" modified="2024-10-02" version="1">MQLTFRPATPSDIPALGAIAFAAFKPSTLIQHISPTSDEAALAFWTQVAQAGLGSGPNTHLVVVEDNSQCPPVIVSFAKWTFVPEGAPLPGIFFSGGGGGGDEDENEAFWATMNNPEFAKEYFGNQAMQHARIVKERAHWYLELITTSPEFQGRGAGKMLMEWGLERVDETGFEAYLEASPEGKGLFEKFGFRVVDEAVYFEGGYVERYMVRRDESICWER</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P7X9</accession>
    <name>A0AAN6P7X9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_51515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854831">
        <property type="protein sequence ID" value="KAK4031386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P7X9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4031386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="189" mass="20804" checksum="57306ABBA48C4A17" modified="2024-10-02" version="1">MSSPFEDPEPCGARRIAKPKSKLRRFQAQAPAEAPANAPAPVPPQAAPPVPVDPVTAPQFSSSTCDQAEPSCEYDYVLLPGEYLRSLCEDWIEARASFMEASPLCGNVSKRWTRTWKDSTLINLGEELPAGVDEAEMEQDDAASLVRRFFQFNLLRRMYGPDASGKNAILRHLKELAAKEGIDLGQVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P8E9</accession>
    <name>A0AAN6P8E9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_39870</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854516">
        <property type="protein sequence ID" value="KAK4033678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P8E9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF252">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08550)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4033678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="325" mass="35038" checksum="52BD4AA49C352077" modified="2024-10-02" version="1">MGQPLIPLTPEGTSVSGKTIIITGGNAGLGLEAARQFLILGCSRMVLACRSIARGQEAAASLRADPAIQKANPSAIIDVFELDLDDYHSGVRFVRQVTSSLTELDILLNNGGMASMRYETSTSGHERTMQVNCYTHILISLALLPLLRRTAAARGSPTRITFVGSGTQKTQASLKGALPEDVSALEYFDDPANFSRFRRYADSKLAVNAYTRRLATLAPGEVVVNNLCPGLVQTGLDKNLPGPLKFIMGWVRKTAARTVEEGARTLVFAAAVAGEETNGKFMQQNKVDEGAPFLNGPHAERFVDRLWKETVEDLVKVDAALGEFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P8J4</accession>
    <name>A0AAN6P8J4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleoside phosphorylase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_19365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854513">
        <property type="protein sequence ID" value="KAK4033714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P8J4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="1">
        <location>
            <begin position="36"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4033714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="300" mass="33062" checksum="9B1FC1D5D9DAEA63" modified="2024-10-02" version="1" fragment="single">MAKRPRTRTFDIASYVGVHASRNEHYSPQLAHGDYTIAWICALPLELAASRAMLDELHLLLPNLDHDDNVYVLGRIYQHNVVMACLGQYGANNAAIVATNLKRSFPNIRATLMVGIGGGSPSQADLFLGDVIVGTRVMQYDMGKMIAGGLFQETADAKTPALLLNSAVSALRSKHGPDRSSSRMTSLIRSRLPNILRPSHPDHLFQASYEHHLLGALICIGYDLEKLQPRGVRFSDEPRIHYGVIASGNRVMKDGKARDEIAQRLSALCFEMEAAGMMDNLQCLPIRGICDYSDSQSEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P8L4</accession>
    <name>A0AAN6P8L4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_51455</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854795">
        <property type="protein sequence ID" value="KAK4031472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P8L4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4031472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="249" mass="27715" checksum="4A8D19D5D32380D0" modified="2024-10-02" version="1">MATGTKTTRFRYSNGEIATAEVAKAFSWEAPVPVNPFWDDIDYCLARNFLGSFSEHELEELPIDPSNGDTYGAKLQLLLHLLEEKLAQEEAAASPSQSLHDANHARWYDLWQAIQAFQSASGLLEAAEVTARMLVARQPEDSTDVRPRHILAEHLVKVGKYAEAEVTARPVCAWMDAQPRLGRGSPQAINSRRMIARALWGQGQPRRAEAAALLAEIDEIVDGMGGGRFAVYQEEEKRLNVQMKAELKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P904</accession>
    <name>A0AAN6P904_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_50312</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854557">
        <property type="protein sequence ID" value="KAK4033022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P904"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF42">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="41"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="290"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="290"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="304"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="329"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4033022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="347" mass="38395" checksum="1C4A51BBC44EE1F8" modified="2024-10-02" version="1">MRLPGMVRRDDSSSGGAPNYAGRLLWAIWSLTIAAAIFLALRVYCKVTRRRSLWWDDHFLVASWVTVLVSTAMLTEGVKYGIGMHYEDMDPLKMQLGIIISYGAGFATILGAAWSKTSFAITLLRISNGWTTWLVWFIIISVNVVLGVSGTILWIQCWPVRKLWTDMEATCWPKEIVEHYQTFTSIYSGVLDIVLAILPWKIIWNVTINKREKLGALVAMSMGVFSGIIAFLKIISLGDITDGSSTTVNIKIFGTAEPAVAIIAASIPILRAFVRRDAATGSQSIPFVQFSQIPDPGSRSSNTSKKEFDEALVRHTSTRSQPAAGAQDVSCQPGTSELRQGRWGWTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P910</accession>
    <name>A0AAN6P910_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_21142</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854727">
        <property type="protein sequence ID" value="KAK4031682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P910"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4031682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="83" mass="8435" checksum="478B1AB5EDA60450" modified="2024-10-02" version="1" fragment="single">SGTASCGVACFTTRAGVPMATLQGGMSLVTTKPAPMVLSSLMATPGKTTTWPPIQQSLPNGDGLHVLDFGLAATDVGLVRRGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P923</accession>
    <name>A0AAN6P923_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Orc1-like AAA ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_40494</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854555">
        <property type="protein sequence ID" value="KAK4033052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P923"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056808">
        <property type="entry name" value="HTH_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36168">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36168:SF1">
        <property type="entry name" value="ORC1-LIKE AAA ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24913">
        <property type="entry name" value="WHD_AAA_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Orc1-like AAA ATPase" evidence="3">
        <location>
            <begin position="161"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="AAA protein C-terminal winged helix" evidence="4">
        <location>
            <begin position="389"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4033052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="555" mass="62157" checksum="13F3FCDEA387951B" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P978</accession>
    <name>A0AAN6P978_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_49478</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family. Isoflavone reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854497">
        <property type="protein sequence ID" value="KAK4034059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P978"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF7">
        <property type="entry name" value="CIPA-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G01630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="4">
        <location>
            <begin position="24"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4034059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="342" mass="37344" checksum="0B647C3E38C90DE5" modified="2024-10-02" version="1">MSSPYAKDQPQGFSNHIKKVAIVGAGGNIGSHIVEQLVKGGKHVVTAISRPGSTNKLPEAVYVLRVDYSGDDISALVDALRGQHALIITMAVSAPKDTMSKLIRAAAAAGVPYILPNWFGHDAANDALCRDSFLTQMRDSVRSEVHSLGVSSPLFLVCNFWYEFSLGGGPDRFGFDFQNRSLVYFDGGNVVINTSSWPQCGRAVAGLLGLKKLPDDEKDTSPTISQFVDDGGLVYVSSFRLSQRDMFESVKRVTETTDADWTITHESSEQRWRDGTAEVLRGNFGAFTKMLYSRMFFPNGDGDYESRRALHNDVLGLPVEDLDLVTSIAVRMGENGEVAQGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P9D8</accession>
    <name>A0AAN6P9D8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ppx/GppA phosphatase family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_18997</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854492">
        <property type="protein sequence ID" value="KAK4034159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P9D8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000191">
        <property type="entry name" value="Retrograde regulation protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.150">
        <property type="entry name" value="Exopolyphosphatase. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050273">
        <property type="entry name" value="GppA/Ppx_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003695">
        <property type="entry name" value="Ppx_GppA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057512">
        <property type="entry name" value="RTG2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30005">
        <property type="entry name" value="EXOPOLYPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30005:SF0">
        <property type="entry name" value="RETROGRADE REGULATION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02541">
        <property type="entry name" value="Ppx-GppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23566">
        <property type="entry name" value="RTG2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ppx/GppA phosphatase N-terminal" evidence="2">
        <location>
            <begin position="53"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="RTG2 C-terminal" evidence="3">
        <location>
            <begin position="402"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4034159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="602" mass="64683" checksum="AF696939AD254567" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PAL8</accession>
    <name>A0AAN6PAL8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Peroxisomal ATPase PEX1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Peroxin-1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">C8A01DRAFT_38733</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854465">
        <property type="protein sequence ID" value="KAK4034803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PAL8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19526">
        <property type="entry name" value="RecA-like_PEX1_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000149">
        <property type="entry name" value="Nuclear valosin-containing protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.330.10:FF:000011">
        <property type="entry name" value="Peroxisome biogenesis protein peroxin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001529">
        <property type="entry name" value="Peroxisome biosynthesis protein-like protein (PAS1/Peroxin-1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015342">
        <property type="entry name" value="PEX1-N_C-lobe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF12">
        <property type="entry name" value="PEROXISOMAL ATPASE PEX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09262">
        <property type="entry name" value="PEX-1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="ADC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="Cdc48 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="549"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="881"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="223"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="711"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1076"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="225"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="239"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK4034803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1253" mass="134030" checksum="5F74ED9683D65BD1" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PBX0</accession>
    <name>A0AAN6PBX0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_38010</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854441">
        <property type="protein sequence ID" value="KAK4038051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PBX0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF33">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="312"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="350"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="386"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="416"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="447"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="481"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="557"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="81"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="31"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="59"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4038051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="587" mass="62374" checksum="44EE75B2386E01E1" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PC48</accession>
    <name>A0AAN6PC48_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_19415</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854516">
        <property type="protein sequence ID" value="KAK4033666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PC48"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4033666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="103" mass="10590" checksum="CF39805CF8A59114" modified="2024-10-02" version="1" fragment="single">TPTTTTTATATNTVTSYPDSCTYRPTQTFYSSSGCALTCATGFCVIDAPATVSCGCPTVFIETQTVTVCATATPCQQCYTGWGTFLYTEACATATETAAAVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PCE7</accession>
    <name>A0AAN6PCE7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1749-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_47998</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854431">
        <property type="protein sequence ID" value="KAK4038364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PCE7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013744">
        <property type="entry name" value="SidJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31591:SF7">
        <property type="entry name" value="DUF1749-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31591">
        <property type="entry name" value="UPF0613 PROTEIN PB24D3.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08538">
        <property type="entry name" value="DUF1749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4038364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="293" mass="31202" checksum="FF216360978AF2B8" modified="2024-10-02" version="1">MASSASPTPFQVTVHPFPSPTPSACAYERGASSARHALVFLGGLTTGPHSTDLTVLANMLGQSPLDYALWEFRMRSSYSGFGYSNLANDVEDVAALVHYLRGLGKEKIVLMGSSTGCQDCLEYAKHQTPPVDGYILTSPVSDRESAFLFMSPENLAKSGQVALDMIDNGRQDDPMPKESLPFIFTTPVTAYRWHSLAAKGGDEDYFSSDLPHSALAATFGRVDKPLLILPAGEDEMVPPTVDREALLGRWIAACKDGVASGLSGFVPGADHAVSSAEAQGWVAERVGAFLGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PCZ5</accession>
    <name>A0AAN6PCZ5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cutinase transcription factor 1 beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_47791</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854423">
        <property type="protein sequence ID" value="KAK4038657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PCZ5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052761">
        <property type="entry name" value="Fungal_Detox/Toxin_TFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47425">
        <property type="entry name" value="FARB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47425:SF3">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="61"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="139"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="173"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4038657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="755" mass="83541" checksum="0BDD2B4647E79DF2" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PDM5</accession>
    <name>A0AAN6PDM5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_17841</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854442">
        <property type="protein sequence ID" value="KAK4038010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PDM5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052350">
        <property type="entry name" value="Metallo-dep_Lactonases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43569">
        <property type="entry name" value="AMIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43569:SF2">
        <property type="entry name" value="AMIDOHYDROLASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="2">
        <location>
            <begin position="7"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4038010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="340" mass="37907" checksum="5ACE1A5B7B664F16" modified="2024-10-02" version="1">MPPHPIIDSHIHLFPASELPSLSWDPTHPLYSQYSLTEFHAATESQQPNLAGFLFVETDRRNDAARDWTAPLQEIAWMRRLATGTPSSPDQGHTAADAKLCLGFVPWAPLTLGPEELGKYLARAEEEAGAETWAKVKGFRYLLQDKENGTALGEGFIESLKVLGRKGFVFDVGVDQHRRGRVQLEEAVEMIDRAHEGVEEGEKVVFILNHLCKPDLTIVSQTDPSFIAWRTAMFTLSKCRKTYMKLSGCFSELPDKLKERSAEDIFAAILPWLAVVVAAFGPSRIMFGSDWPVCTMGVGEDAWKKWHKVVDMVCDLAGLSEEDQAMLWAGTAKEAYKLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PEF7</accession>
    <name>A0AAN6PEF7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_36951</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854410">
        <property type="protein sequence ID" value="KAK4039117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PEF7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000008">
        <property type="entry name" value="C6 zinc finger domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053181">
        <property type="entry name" value="EcdB-like_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785:SF2">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="136"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="86"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4039117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="709" mass="78521" checksum="FB79D2D84560643C" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PEJ2</accession>
    <name>A0AAN6PEJ2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Mediator of RNA polymerase II transcription subunit 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Mediator complex subunit 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_36863</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the Mediator complex subunit 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854408">
        <property type="protein sequence ID" value="KAK4039177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PEJ2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019680">
        <property type="entry name" value="Mediator_Med1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35041">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35041:SF4">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10744">
        <property type="entry name" value="Med1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0010">Activator</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit Med1" evidence="9">
        <location>
            <begin position="111"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="455"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="570"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="460"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4039177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="684" mass="74848" checksum="AFC60DE83C6F6E66" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PES7</accession>
    <name>A0AAN6PES7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_18206</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854456">
        <property type="protein sequence ID" value="KAK4035076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PES7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4035076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="138" mass="14832" checksum="1C4856E9F4337E06" modified="2024-10-02" version="1">MSSASPQLNSSSCPTGEASIPTSFASIPTNISYVAVPGQNVTERWMVRCCEPYPVQLVDGCWEWCQIDPEQERNVSQQLLEIRYDACFRNYGRPLSESGSMYHFHSGAGAAVSARVSVLRSVVVALAASGVVALVSGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PEY5</accession>
    <name>A0AAN6PEY5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">t-SNARE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_37242</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the syntaxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854418">
        <property type="protein sequence ID" value="KAK4038833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PEY5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15849">
        <property type="entry name" value="SNARE_Sso1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006011">
        <property type="entry name" value="Syntaxin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF380">
        <property type="entry name" value="SYNTAXIN FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00804">
        <property type="entry name" value="Syntaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="299"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="5">
        <location>
            <begin position="225"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="37"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="235"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4038833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="400" mass="43982" checksum="449DB13443EDBC9D" modified="2024-10-02" version="1">MSYGGYNPYGDNGGGRGYGADPFDDRNALQYGAGTHEMASFSPGRSPQAAPFSAGNSPQMGYGSPGPQNQNSILDECTDIQRGIRDIENKLGVLGALQKRSLEDADMSGGSNTKRELDNLTQAVMDQYRQLTDRLRIVKSNPDSRQQRNKSQVNKADQDLRKAIQKFQELEAGSRREMQTQMERQARLVYPDATDSEIADIVKDDNQIFQQAVMGVRAEKANRVLGAVKERHQDMLKIERDLMQLLDLLNDMQELLTKQEEVIVEVGTNTAKAADLVEDANTKLEIAAVSSRGARKKKFICLGICVLIVVIIVVAVVAYIMVNRAANGGGSKKRNLFQRSVMDDLQMNTARAVEVSPRLPRRLASRARGVGAAPNHEVEVAAKKRFVVDWEGAGPTGSDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PF26</accession>
    <name>A0AAN6PF26_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">R3H domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">C8A01DRAFT_17069</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Regulates global gene expression after oxidative stress. Interacts and stabilizes mRNAs and may regulate their transition between different cytoplasmic components after oxidative stress.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Interacts with csx1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854416">
        <property type="protein sequence ID" value="KAK4038908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PF26"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02639">
        <property type="entry name" value="R3H_RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12253">
        <property type="entry name" value="RRM_PIN4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.50:FF:000002">
        <property type="entry name" value="Immunoglobulin mu DNA-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000183">
        <property type="entry name" value="R3H domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034186">
        <property type="entry name" value="PIN4-like_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034069">
        <property type="entry name" value="R3H_Cip2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003:SF17">
        <property type="entry name" value="RNA-BINDING PROTEIN PIN4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00393">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="15">
        <location>
            <begin position="192"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="R3H" evidence="16">
        <location>
            <begin position="348"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="15"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="275"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="448"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="523"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="17"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="295"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="523"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="595"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="619"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00055199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00062407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAK4038908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="19">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="638" mass="69210" checksum="8908D8711FC53533" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PF56</accession>
    <name>A0AAN6PF56_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_16286</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854392">
        <property type="protein sequence ID" value="KAK4039776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PF56"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF92">
        <property type="entry name" value="METHYLTRANSFERASE TYPE 11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="3">
        <location>
            <begin position="736"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="84"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="138"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="343"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="371"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="500"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="99"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="155"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="343"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="500"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4039776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1018" mass="112033" checksum="0C2C0C3DD11DF69A" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PFA5</accession>
    <name>A0AAN6PFA5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_16392</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854395">
        <property type="protein sequence ID" value="KAK4039662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PFA5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033140">
        <property type="entry name" value="Lipase_GDXG_put_SER_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF18">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01174">
        <property type="entry name" value="LIPASE_GDXG_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="4">
        <location>
            <begin position="119"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4039662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="381" mass="41682" checksum="401F7199AAB9D28F" modified="2024-10-02" version="1">MASKDPANTPGELSVWDRVTLVGLFPLNPVLHWRQRLALAFLQAQRASFPTRHLRWLNRRVSTGEAILRHCDKHKIPHRTVTLDARTTSDRAAEASIPAPTLHFLTPPAAPDNESGPTLVYFHGGGFVNPLRGAAHMPFIMRCAGACRAKQVVVLEYVLSPEHPYPAQLVQCVATLRHLVDEMGLRPGDLVLAGDSAGGQLVGALLAHLVKPSPYAAPVKLNGKFRAALFVSPFVRLQEGVGSYETNDGKDYLNRSQVDKFMSAWKGNGEEIWADLCGASESGDVWRQVFARGSQGLVRKVMVTVGTADILLDSCRVFAKEHVQAETVLAGRDRDYKVFDGKDMVLAECDGEVHVQVALDSVVGYEKGSMERAIMSWLAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PGV5</accession>
    <name>A0AAN6PGV5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NTF2-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_17207</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854420">
        <property type="protein sequence ID" value="KAK4038744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PGV5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="486"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="511"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4038744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="552" mass="60646" checksum="113269E5C579611A" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PGZ4</accession>
    <name>A0AAN6PGZ4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Pentafunctional AROM polypeptide</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="21">3-dehydroquinate synthase</fullName>
                <shortName evidence="21">DHQS</shortName>
                <ecNumber evidence="21">4.2.3.4</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="21">3-phosphoshikimate 1-carboxyvinyltransferase</fullName>
                <ecNumber evidence="21">2.5.1.19</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="21">5-enolpyruvylshikimate-3-phosphate synthase</fullName>
                <shortName evidence="21">EPSP synthase</shortName>
                <shortName evidence="21">EPSPS</shortName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="21">Shikimate kinase</fullName>
                <shortName evidence="21">SK</shortName>
                <ecNumber evidence="21">2.7.1.71</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="21">3-dehydroquinate dehydratase</fullName>
                <shortName evidence="21">3-dehydroquinase</shortName>
                <ecNumber evidence="21">4.2.1.10</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="21">Shikimate dehydrogenase</fullName>
                <ecNumber evidence="21">1.1.1.25</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="28" type="ORF">C8A01DRAFT_35425</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="29" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="29">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20 21 22">The AROM polypeptide catalyzes 5 consecutive enzymatic reactions in prechorismate polyaromatic amino acid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21 22">
            <text>3-dehydroquinate = 3-dehydroshikimate + H2O</text>
            <dbReference type="Rhea" id="RHEA:21096"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="EC" id="4.2.1.10"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21256"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="EC" id="2.5.1.19"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:21257"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21 22">
            <text>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate = 3-dehydroquinate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21968"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="EC" id="4.2.3.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19 21 22">
            <text>shikimate + ATP = 3-phosphoshikimate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13121"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.71"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21 22">
            <text>shikimate + NADP(+) = 3-dehydroshikimate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17737"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="21 22">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="21 22">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="21 22">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="21 22">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="21 22">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 21 22">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 21 22">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="21 22">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 21 22">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the EPSP synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="21 22">In the 2nd section; belongs to the EPSP synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="21 22">In the 3rd section; belongs to the shikimate kinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="21 22">In the 4th section; belongs to the type-I 3-dehydroquinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="21 22">In the C-terminal section; belongs to the shikimate dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="22">In the N-terminal section; belongs to the dehydroquinate synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="21">In the N-terminal section; belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="28">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.4" evidence="21"/>
    <dbReference type="EC" id="2.5.1.19" evidence="21"/>
    <dbReference type="EC" id="2.7.1.71" evidence="21"/>
    <dbReference type="EC" id="4.2.1.10" evidence="21"/>
    <dbReference type="EC" id="1.1.1.25" evidence="21"/>
    <dbReference type="EMBL" id="MU854374">
        <property type="protein sequence ID" value="KAK4040562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003855">
        <property type="term" value="F:3-dehydroquinate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003856">
        <property type="term" value="F:3-dehydroquinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003866">
        <property type="term" value="F:3-phosphoshikimate 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004765">
        <property type="term" value="F:shikimate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00502">
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        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
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        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
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        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
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    <feature type="active site" description="Proton acceptor; for 3-dehydroquinate synthase activity" evidence="21">
        <location>
            <position position="275"/>
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            <position position="819"/>
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        <location>
            <position position="1170"/>
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    <feature type="active site" description="Schiff-base intermediate with substrate; for 3-dehydroquinate dehydratase activity" evidence="21">
        <location>
            <position position="1198"/>
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    <feature type="binding site" evidence="21">
        <location>
            <begin position="49"/>
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        <ligand>
            <name>NAD(+)</name>
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    <feature type="binding site" evidence="21">
        <location>
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        <ligand>
            <name>NAD(+)</name>
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    <feature type="binding site" evidence="21">
        <location>
            <begin position="114"/>
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        <ligand>
            <name>NAD(+)</name>
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    <feature type="binding site" evidence="21">
        <location>
            <position position="119"/>
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        <ligand>
            <name>NAD(+)</name>
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    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="130"/>
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        <ligand>
            <name>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate</name>
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    <feature type="binding site" evidence="21">
        <location>
            <begin position="139"/>
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        <ligand>
            <name>NAD(+)</name>
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    <feature type="binding site" evidence="21">
        <location>
            <position position="146"/>
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        <ligand>
            <name>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate</name>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="152"/>
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        <ligand>
            <name>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate</name>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="161"/>
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        <ligand>
            <name>NAD(+)</name>
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    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="162"/>
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        <ligand>
            <name>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate</name>
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        </ligand>
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    <feature type="binding site" evidence="21">
        <location>
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        <ligand>
            <name>NAD(+)</name>
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    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="190"/>
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        <ligand>
            <name>NAD(+)</name>
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    <feature type="binding site" evidence="21">
        <location>
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        <ligand>
            <name>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate</name>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="194"/>
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        <ligand>
            <name>Zn(2+)</name>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="250"/>
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        <ligand>
            <name>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate</name>
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    <feature type="binding site" evidence="21">
        <location>
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        <ligand>
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        </ligand>
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    <feature type="binding site" evidence="21">
        <location>
            <position position="271"/>
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        <ligand>
            <name>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate</name>
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    </feature>
    <feature type="binding site" evidence="21">
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            <position position="271"/>
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        <ligand>
            <name>Zn(2+)</name>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="287"/>
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        <ligand>
            <name>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate</name>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
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            <position position="287"/>
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        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="356"/>
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        <ligand>
            <name>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate</name>
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    <feature type="binding site" evidence="21">
        <location>
            <begin position="866"/>
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        <ligand>
            <name>ATP</name>
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    </feature>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00004811"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004842"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00009948"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
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    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
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    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00044633"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00048567"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00054455"/>
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    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRNR" id="PIRNR000514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF00275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF01761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF08501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF18317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="Pfam" id="PF24621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="KAK4040562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1576" mass="169960" checksum="1EF09FA726A8D6DD" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PHU0</accession>
    <name>A0AAN6PHU0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein mL53</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_47214</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL53 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854405">
        <property type="protein sequence ID" value="KAK4039254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PHU0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000260">
        <property type="entry name" value="Mitochondrial ribosomal protein L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019716">
        <property type="entry name" value="Ribosomal_mL53"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042776">
        <property type="entry name" value="Ribosomal_mL53_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28236">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L44, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28236:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10780">
        <property type="entry name" value="MRP_L53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 7" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4039254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="98" mass="10922" checksum="2184057BD418EB5E" modified="2024-10-02" version="1">MITRFITDVTTRFNPFSARARSARLFLSFLPPTARASGMSITTQLLPRGSTEASSLRIKFKDGKEMQLDCEAMGIKSIVEEVDRHSRMLQKEADLAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PHX5</accession>
    <name>A0AAN6PHX5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_16540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854399">
        <property type="protein sequence ID" value="KAK4039496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PHX5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4039496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="283" mass="31585" checksum="D586DE9F6DADC0FB" modified="2024-10-02" version="1">MSGNNGAKQAEPAYMLPHSHQEIERMKNQHEWIKGSFGGLIKAPINLFKKHQRILDSAAADGTWLCDISTLFPPETELVGFDIAPQLYPPPDRLPPNVNLVPGDLSKALPAEWDQHFDLVHQRFVFPGFSSAIVGQFLGRLMACVKPGGWIQLVEPAADENVSGPDAVGFAVLHRLAAACTQCPDPRDTILSTLKDGGFINVNIQTMDLVVGVFQENRELDARGRKSMRDARKEVANIKSRRSPEALGMSEADWETVLHRFDTDMEKYRTAVRHNIIWAQRPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PHZ4</accession>
    <name>A0AAN6PHZ4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldo/keto reductase family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_16512</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854398">
        <property type="protein sequence ID" value="KAK4039526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PHZ4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045290">
        <property type="term" value="F:D-arabinose 1-dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070485">
        <property type="term" value="P:dehydro-D-arabinono-1,4-lactone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42686">
        <property type="entry name" value="GH17980P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42686:SF1">
        <property type="entry name" value="GH17980P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="24"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4039526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="451" mass="48255" checksum="27033B7526E27548" modified="2024-10-02" version="1">MAGPSNPAAPSTPPRPPLHAVLPPLVLGTATFNTQFVADPHSMPYRDIVARALSLGVNAFDTSPYYGPSETLLGTALDALMNPGPGPGPNPAVPLPRSGFFLVTKAGRVASTEFDYSPAWIRYSILRSLQRLHTPYLDLVYMHDVEFVSPAEVLAAVRELRRLRDEDGVVRYVGICGFPVDTLCSLAEMVYAETGEPLDAVLSYGHFTVQNRRLGVPWVDAEQEEGGGQGSPLARFKKAGVDVVLNASILGMGLLTSRGIPADPQAPDEGGDDAGPLVHWHPSPPELRVACKKLAELSAAAGERLESVAIRWSMAEWARLAAAAGLGVDIATPGVGPRKIGATVCGVTTIGELEETVTEWRGVLASLGQAVGRGDEVYGSARQEKVLSLVRNELWPALRSWLDYVWDSPGPGFVNTRREADRGTIPDDGVVAAYEKAKLGRRTVQSTAEPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PHZ5</accession>
    <name>A0AAN6PHZ5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Calcium permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">C8A01DRAFT_37157</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854416">
        <property type="protein sequence ID" value="KAK4038905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PHZ5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000017">
        <property type="entry name" value="Calcium permease family membrane transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005185">
        <property type="entry name" value="YccF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF10">
        <property type="entry name" value="VNX1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03733">
        <property type="entry name" value="YccF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="255"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="400"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="423"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="495"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="527"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="559"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="595"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="627"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="703"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="927"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="960"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="995"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1034"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1065"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="domain" description="Inner membrane component" evidence="11">
        <location>
            <begin position="258"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="529"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="927"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="150"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="737"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="780"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="871"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="19"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="191"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="894"/>
            <end position="910"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK4038905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1122" mass="121461" checksum="0DCBEACD5DE0A4B7" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PIH7</accession>
    <name>A0AAN6PIH7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 13">Ribulose-phosphate 3-epimerase</fullName>
            <ecNumber evidence="8 13">5.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">C8A01DRAFT_36216</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>D-ribulose 5-phosphate = D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:13677"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="EC" id="5.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="15">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Carbohydrate degradation; pentose phosphate pathway; D-xylulose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 13">Belongs to the ribulose-phosphate 3-epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.1" evidence="8 13"/>
    <dbReference type="EMBL" id="MU854392">
        <property type="protein sequence ID" value="KAK4039766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PIH7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004750">
        <property type="term" value="F:D-ribulose-phosphate 3-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00429">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000130">
        <property type="entry name" value="Ribulose-phosphate 3-epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02227">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026019">
        <property type="entry name" value="Ribul_P_3_epim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000056">
        <property type="entry name" value="Ribul_P_3_epim-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004076">
        <property type="entry name" value="PRK05581.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11749">
        <property type="entry name" value="RIBULOSE-5-PHOSPHATE-3-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00834">
        <property type="entry name" value="Ribul_P_3_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001461">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01085">
        <property type="entry name" value="RIBUL_P_3_EPIMER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01086">
        <property type="entry name" value="RIBUL_P_3_EPIMER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="12 15" id="KW-0170">Cobalt</keyword>
    <keyword evidence="11 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="15" id="KW-0464">Manganese</keyword>
    <keyword evidence="10 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="14">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="174"/>
            <end position="177"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="225"/>
            <end position="226"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00009541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00013188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00013920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR001461"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR001461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-2"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR001461-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAK4039766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="252" mass="26906" checksum="2F6940609E2DFC84" modified="2024-10-02" version="1">MAPKAIIAPSILSADFADLGAACSRTIEQGADWLHVDIMDGHFVPNLTFGPPVVAKIRSHVDRPTEGHGKGTFDCHMMIAEPKKWVKEFKAAGCDLYCFHYEAAVNSSAAESPEAHSDLKTSPRELIRYIHQQGMLAGIAIKPATKAEVLYEVLDSADEAERPDMVLVMTVEPGFGGQKFMASELPKVQALRERYPELNIEVDGGLGPGTIDQAADAGANVIVAGSAVFGAQDPAGVIALLREAVDKRGGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PII3</accession>
    <name>A0AAN6PII3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_45251</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854354">
        <property type="protein sequence ID" value="KAK4041598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PII3"/>
    <dbReference type="Proteomes" id="UP001303115">
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    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="319"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4041598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="540" mass="61063" checksum="E7F750DB2B408C97" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PIN8</accession>
    <name>A0AAN6PIN8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heterokaryon incompatibility protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_16336</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854393">
        <property type="protein sequence ID" value="KAK4039719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PIN8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26639">
        <property type="entry name" value="Het-6_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="46"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4039719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="577" mass="64476" checksum="E6CA769FC893A9E4" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PJD0</accession>
    <name>A0AAN6PJD0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fungal-specific transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_15983</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854384">
        <property type="protein sequence ID" value="KAK4040094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PJD0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF4">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="644"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="21"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="86"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="720"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="101"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4040094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="794" mass="87146" checksum="B5E742E85C8AA5CF" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PKQ4</accession>
    <name>A0AAN6PKQ4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-NAD kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_15837</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854381">
        <property type="protein sequence ID" value="KAK4040255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PKQ4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001727">
        <property type="term" value="F:lipid kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055916">
        <property type="entry name" value="DUF7493"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050187">
        <property type="entry name" value="Lipid_Phosphate_FormReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358:SF31">
        <property type="entry name" value="ACYLGLYCEROL KINASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358">
        <property type="entry name" value="SPHINGOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24321">
        <property type="entry name" value="DUF7493"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAGKc" evidence="2">
        <location>
            <begin position="149"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="351"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4040255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="551" mass="59506" checksum="571FEC7E5FDE774F" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PKS7</accession>
    <name>A0AAN6PKS7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">V-type proton ATPase subunit D</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">V-type proton ATPase subunit d</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10 11">Vacuolar proton pump subunit D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">C8A01DRAFT_33071</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Vacuole membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase D subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854335">
        <property type="protein sequence ID" value="KAK4042819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PKS7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016471">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.3240:FF:000002">
        <property type="entry name" value="Vacuolar atp synthase subunit d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002699">
        <property type="entry name" value="V_ATPase_D"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00309">
        <property type="entry name" value="V_ATPase_subD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11671">
        <property type="entry name" value="V-TYPE ATP SYNTHASE SUBUNIT D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01813">
        <property type="entry name" value="ATP-synt_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0926">Vacuole</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="214"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="253"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00046254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK4042819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="262" mass="29233" checksum="32C2043935406B5D" modified="2024-10-02" version="1">MSGAGDREAVFPTRQSLGIMKAKLKGAETGHNLLKRKSEALTKRFREITRRIDEAKRKMGRVMQIASLSLAEVTYAVGGNIGYQIQESAKSARFRIRAKQENVSGVLLPAFESYLTEGNNDFAMTGLGKGGQQVQRCRETYARAVEALVELASLQTAFVILDEVIKVVNRRVNAIEHVIIPRTENTIKYINSELDELDREEFYRLKKVANKKQRDTAAADAEMKKKKDEIAARGEENVSPEPEEASGPSDLLAAEEDEDVIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PL23</accession>
    <name>A0AAN6PL23_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GTPase-activating protein gyp1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_33229</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854337">
        <property type="protein sequence ID" value="KAK4042702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PL23"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000037">
        <property type="entry name" value="TBC1 domain family member 22A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000001">
        <property type="entry name" value="TBC1 domain family member 22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF26">
        <property type="entry name" value="LD44506P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="277"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4042702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="611" mass="68531" checksum="ADC31DEDB0E810EC" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PL32</accession>
    <name>A0AAN6PL32_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Trehalase</fullName>
            <ecNumber evidence="8">3.2.1.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Alpha-trehalose glucohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">C8A01DRAFT_44337</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>alpha,alpha-trehalose + H2O = alpha-D-glucose + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:32675"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:16551"/>
            <dbReference type="ChEBI" id="CHEBI:17925"/>
            <dbReference type="EC" id="3.2.1.28"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 8">Belongs to the glycosyl hydrolase 37 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.28" evidence="8"/>
    <dbReference type="EMBL" id="MU854337">
        <property type="protein sequence ID" value="KAK4042717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PL32"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004555">
        <property type="term" value="F:alpha,alpha-trehalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005993">
        <property type="term" value="P:trehalose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000026">
        <property type="entry name" value="Trehalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001661">
        <property type="entry name" value="Glyco_hydro_37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018232">
        <property type="entry name" value="Glyco_hydro_37_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011120">
        <property type="entry name" value="Trehalase_Ca-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403:SF6">
        <property type="entry name" value="CYTOSOLIC NEUTRAL TREHALASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01204">
        <property type="entry name" value="Trehalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07492">
        <property type="entry name" value="Trehalase_Ca-bi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00744">
        <property type="entry name" value="GLHYDRLASE37"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00927">
        <property type="entry name" value="TREHALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00928">
        <property type="entry name" value="TREHALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="7 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 8 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Neutral trehalase Ca2+ binding" evidence="10">
        <location>
            <begin position="91"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK4042717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="743" mass="85129" checksum="E2CC74094A777FDA" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PL77</accession>
    <name>A0AAN6PL77_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_44863</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854346">
        <property type="protein sequence ID" value="KAK4042090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PL77"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="649"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="712"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="262"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="432"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="487"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="566"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="580"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="652"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="732"/>
            <end position="742"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4042090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="742" mass="82241" checksum="DE6F917D5127A60C" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PL89</accession>
    <name>A0AAN6PL89_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_44949</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854348">
        <property type="protein sequence ID" value="KAK4041968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PL89"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12245">
        <property type="entry name" value="RRM_scw1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000089">
        <property type="entry name" value="RNA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10501">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN A/U2 SMALL NUCLEAR RIBONUCLEOPROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="382"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="57"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="462"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="472"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4041968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="566" mass="58759" checksum="8D164ED04EE0B283" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PLI7</accession>
    <name>A0AAN6PLI7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_35279</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854371">
        <property type="protein sequence ID" value="KAK4040720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PLI7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4040720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="167" mass="18731" checksum="744E16779D56DA85" modified="2024-10-02" version="1">MNRAHVLLAVDDLRFWLNSLHKAAVHWESTTTILTIDLLDKISGLGVDREEILRERIKVLEKKLAALRDLSNALDWVLSSDRAVHAAPASGDVPDITDLEARVKDEGMPEGELRGIWSRVLDMAVVVSEKASLLRDEVRKVEAVAESLEDLDWEPDEAPLTVMLRFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2025-10-08" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PLN9</accession>
    <name>A0AAN6PLN9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_44710</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854343">
        <property type="protein sequence ID" value="KAK4042330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18966">
        <property type="entry name" value="chromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="3">
        <location>
            <begin position="39"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="107"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="367"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="610"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1208"/>
            <end position="1301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1373"/>
            <end position="1417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="114"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="145"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="178"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="207"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="280"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="302"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="367"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="615"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1211"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1258"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1281"/>
            <end position="1292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1396"/>
            <end position="1406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4042330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1417" mass="157878" checksum="905D956561D5C3E1" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PME6</accession>
    <name>A0AAN6PME6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_45366</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854356">
        <property type="protein sequence ID" value="KAK4041521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PME6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05380">
        <property type="entry name" value="CAP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.33.10:FF:000018">
        <property type="entry name" value="SCP-like extracellular protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018244">
        <property type="entry name" value="Allrgn_V5/Tpx1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01009">
        <property type="entry name" value="CRISP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042946758" evidence="2">
        <location>
            <begin position="18"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="3">
        <location>
            <begin position="142"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4041521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="313" mass="32985" checksum="0864F1CDBECE3270" modified="2024-10-02" version="1">MKSSVFLASCGAILAAASPILQDRKLYVKTDIVVEWVTVTVTEGDTSTVFRRPSPRPTTTTTSTSAPPPPPPPPPPSSTSEAVVEAAADPTPSPDPTPSPAPVVESPEPNVHAVQPSSEPAPAPAPAPSPSSTKPQTAEPTDYASTAVYHHNVHRFNHSANALEWSDEHAGYAKTLAERCVFEHDTKIGGGGYGQNLAMWGSSENPEAFGATASVARAASNGWYNGELNDFPSSDYGKDSPNMSNFEKWGHFSQLVWAETKQVGCHTHFCEPGTMSGMGSWYTVCNYYPAGNMGGAYAKNVLPPQGGATIKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PMG5</accession>
    <name>A0AAN6PMG5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_34804</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854362">
        <property type="protein sequence ID" value="KAK4041185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PMG5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576:SF158">
        <property type="entry name" value="RIBOSOMAL RNA-PROCESSING PROTEIN 12-LIKE CONSERVED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576">
        <property type="entry name" value="UNCHARACTERIZED NODULIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="330"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="409"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="436"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="470"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="516"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="203"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="203"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="237"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4041185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="553" mass="59287" checksum="86FFB0069EE1D709" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PMT0</accession>
    <name>A0AAN6PMT0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_43232</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asaB hydroxylase/desaturase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854323">
        <property type="protein sequence ID" value="KAK4043856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PMT0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044053">
        <property type="entry name" value="AsaB-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041278">
        <property type="entry name" value="CmcJ_NvfI_EfuI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598">
        <property type="entry name" value="BLL6449 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598:SF3">
        <property type="entry name" value="OXIDOREDUCTASE AN1597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4043856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="209" mass="24031" checksum="A4F024A1B179B18D" modified="2024-10-02" version="1">MHNLVSENYRVSIADVSGHEGRFSLPVSGFEFAKCPVAVQNWSDDYVSSEYLPGLVEWLKPRLGCRDVFCYAYNATCQARLQLYFPDSYQDIMQDRVRFINVWRPISPAPVEDCPLALCDFRTVDREDLVPMDIVYPHFVDEAYEVKYNPSHRWFYKKGMTQEDVIVFKLYDSLRSEATVCPHSAFVDPSAPLDTPRRASVEVKAIVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PN01</accession>
    <name>A0AAN6PN01_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_45045</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854350">
        <property type="protein sequence ID" value="KAK4041836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PN01"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4041836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="326" mass="36841" checksum="BC37BC4F19D4FD50" modified="2024-10-02" version="1">MSVLDFEHAESFKQALDRLLSTDTAEVTYSEIVDGLPTIDSFFDFHFEPEHEGHPVLALDHASLCPGVVERTREFRNQFDMLQLTLPSALLSAFQQSHRGTQQYELRLVELLAVSCHQIAVYLFELDDGVHKHRLYQEWRDSGRESGEYLAPAVFCHGSYVDSDQYPNGAKIFGGVVVFDLLGSLLHPATLDGPHTIFPPTPTQYTALIDLLGPAAAPYAAPCPFPVRATADNRWRYDPWDSMTRFNIFRDRYERKPPNGPRPHHCVKSSRDWPELGDEHLVALLQYQASQGQPVDQAGIDAAYERMKQITPSSPLWPSRRDPGLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PNG9</accession>
    <name>A0AAN6PNG9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_12286</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854320">
        <property type="protein sequence ID" value="KAK4044289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PNG9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052400">
        <property type="entry name" value="Zn2-C6_fungal_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN ECM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657:SF13">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="22"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4044289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="490" mass="53105" checksum="4532F6AF24D7FFB3" modified="2024-10-02" version="1">MTAASSPSTRKSIRPHRKSRAGCSLCKRRKVKCGEEKPCRNCISFGLPCDLVSDGERVEYSTAPAARRGRGRPRKIWTGSVQSPNHCSAATGPSHIASPLSRRSPTCSPLPVDVDPARIDLDNAELLLHFVTTTAETFAGGESPGLNRFWTRNAPQIGLSHAFVLHLIFASAAFHLAYLAKEESEQGLIDINAQLPPHSRGRAGYLFLAQQHLTAGASGFSRQLSRPGPDNCGALYLGAVLTSYCTFAAGPTSRDDLLVCTADAGDTQDATAASSSSASWMPFVYGVRLMHQSFSPDVLFAGLMAPFRTGPVAGSLEEPVCVQNGFRRLDWEDALDGLREFIARSGVVPGGETGTGSTTAVCFAALDAIIEIYAATYGRRSSPDGDATYTGPSANQFVFGWLYRVEYEFVACVRRREPYALLVLAHYAVLLNGDTIQRGWFIKGWREHIIARVGEFLANGECSEWMRWPMEQAAPKGERRGWASPGLIPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PP58</accession>
    <name>A0AAN6PP58_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribosome maturation protein SDO1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">C8A01DRAFT_12024</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Associates with the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SDO1/SBDS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854317">
        <property type="protein sequence ID" value="KAK4044643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PP58"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1250.10:FF:000001">
        <property type="entry name" value="SBDS, ribosome maturation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1250.10">
        <property type="entry name" value="Ribosome maturation protein SBDS, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.900">
        <property type="entry name" value="SBDS protein C-terminal domain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036786">
        <property type="entry name" value="Ribosome_mat_SBDS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002140">
        <property type="entry name" value="Sdo1/SBDS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039100">
        <property type="entry name" value="Sdo1/SBDS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046928">
        <property type="entry name" value="SDO1/SBDS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018978">
        <property type="entry name" value="SDO1/SBDS_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037188">
        <property type="entry name" value="Sdo1/SBDS_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019783">
        <property type="entry name" value="SDO1/SBDS_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00291">
        <property type="entry name" value="RNA_SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10927">
        <property type="entry name" value="RIBOSOME MATURATION PROTEIN SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10927:SF1">
        <property type="entry name" value="RIBOSOME MATURATION PROTEIN SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20268">
        <property type="entry name" value="SBDS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09377">
        <property type="entry name" value="SBDS_domain_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01172">
        <property type="entry name" value="SBDS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89895">
        <property type="entry name" value="FYSH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109728">
        <property type="entry name" value="Hypothetical protein AF0491, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS N-terminal" evidence="10">
        <location>
            <begin position="14"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS central" evidence="11">
        <location>
            <begin position="110"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS C-terminal" evidence="12">
        <location>
            <begin position="268"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="141"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="147"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00071414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF09377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF20268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK4044643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="332" mass="35657" checksum="689AC7C84900DDD2" modified="2024-10-02" version="1">MVIQQPSNQIKLTNVSLVRLKKGKKRFEIACYKNKVLEWRSGIETDLDNVLQIPSVFLNVSKGQTAPSAELAKAFGKDTSVDDIILEILRKGELQVGEKERTAQLERVHNEVISIVASKLVDPRTKRVYTSGMIDKALDMLSSQAHQQQQQQDKTSTSSNNPSTTGTPATGEAGESKPRPPPTAAAATAAAAGGKVATWTGVTTTKSAKSQALDAMRALIAHQPIPVARARMRLRITCSTNVLKQAVKAPKAKETAEGGAAAEGEQKAPGTVKDKILSFIEQVENQDVMGSEWEIVGFVEPGAFKGLSDFVGGETKGQGRVEVLDMAVTHDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PPB9</accession>
    <name>A0AAN6PPB9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_42688</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854318">
        <property type="protein sequence ID" value="KAK4044507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PPB9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="308"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="346"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4044507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="442" mass="47807" checksum="0DBA550A6D623820" modified="2024-10-02" version="1">MIRRPYQPSSGLRLCQACELLSGRQWIRPANRSSAALHLGRRSARLSRTPLIQPVAARSFTTSQPCLKVKRSQEPQGPESSPSRFSRTGAAATYQPPGPDSAAVASAVDRVLRVFLGPSGVPSEATTLTALRGIAQIDVRPAPDVGVSRSEDSAAETRRPASQLLGLDDVAAKAGDAARPQRSPSQRSQDVVDKVSDAAYTIVTQPTVVITRTILAEYVQLQARLGRPQSLPQILDLYASKPKPKLVSGAIRYVERNPSKAESAVDPAVAETALGAAIEAKDLEAAIGILENTYAAKAFLRSKLIKKAFLPGFAVAGTPVAIYYAATQLAQMQHALEPKIATGFAFAGAICYVGFTATIGMVAHFTANDQMKRVTWALGTPLRHRWLHEEERAALDKIACSFGFSEEHRYGEEEGEDFLWLREYILSRSMILDAVDLMPGMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PQN9</accession>
    <name>A0AAN6PQN9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">4-nitrophenylphosphatase</fullName>
            <shortName evidence="5">PNPPase</shortName>
            <ecNumber evidence="3 5">3.1.3.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_43847</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2 5">
            <text>4-nitrophenyl phosphate + H2O = 4-nitrophenol + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21664"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57917"/>
            <dbReference type="ChEBI" id="CHEBI:61146"/>
            <dbReference type="EC" id="3.1.3.41"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Divalent metal ions. Mg(2+) is the most effective.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.41" evidence="3 5"/>
    <dbReference type="EMBL" id="MU854330">
        <property type="protein sequence ID" value="KAK4043201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PQN9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004035">
        <property type="term" value="F:alkaline phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008967">
        <property type="term" value="F:phosphoglycolate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000039">
        <property type="entry name" value="Phosphoglycolate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006349">
        <property type="entry name" value="PGP_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01452">
        <property type="entry name" value="PGP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288">
        <property type="entry name" value="4-NITROPHENYLPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288:SF46">
        <property type="entry name" value="HALOACID DEHALOGENASE-LIKE HYDROLASE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13242">
        <property type="entry name" value="Hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000915">
        <property type="entry name" value="PGP-type_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="27"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="29"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00050247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00066659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00069197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR000915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000915-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000915-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000915-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4043201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="310" mass="33597" checksum="9AF496C1D81EB6E1" modified="2024-10-02" version="1">MTKPKYLTGDNAAINEFIDRFDVFLLDCDGVIWSGDHVFEGVPETLEYLRSRGKKVVFVTNNSTKSREEYLKKFTGLGIPSDVEEIFGSAYSSAIYISRILQLPAPKNKVFVIGEAGIEHELRSEKVPFIGGTDPAFRRDITPEDWKGIADGSLLDPDVGVVLAGLDFHINYLKLSHALQYLRRGAVFLATNTDSTFPANHSFFPGAGSIGTPLAYMTGAQPLALGKPSQAMMDAVEGKFRLDRARTCMVGDRLNTDIKFGVEGRLGGTLAVLTGVARQADWEADDAVAVPAFYVDRLSDLGAAAAAVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PR89</accession>
    <name>A0AAN6PR89_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein mL54</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_31286</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the mitochondrion-specific ribosomal protein mL54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854318">
        <property type="protein sequence ID" value="KAK4044503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PR89"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013870">
        <property type="entry name" value="Ribosomal_mL54"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28595">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L54, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28595:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08561">
        <property type="entry name" value="Ribosomal_L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="128"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4044503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="315" mass="34557" checksum="C5A333ECF787DE53" modified="2024-10-02" version="1">MPTPESEAFLAKKPKVPPTFDGVDYDDTKRLKQAQDAIIREQWVQVMMGRLVREELSKCYYREGVNHLEKCGRLRERYLELLANAKVKGYLFEQQNYFSKDGFTTRQITAQPLARTSAAAATRPFTTTLTTRNAAPSPAAAAPATASASASDESSSTPDLTPLTPPAADSSAPSLSSCPAGTVLNGLNYFKGKTDPVALADDAYPAWLWKCLEVQKKADAAADADAGDEFSKSKKQRRLALKRQRLQEARLLASGDLEALVPKIPLQKQTVNLPAAAVGDLGQALEAVDKREELRQAMRKERRAKIKEANYLKAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PTM7</accession>
    <name>A0AAN6PTM7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF6314 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_42791</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FMO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854319">
        <property type="protein sequence ID" value="KAK4044350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PTM7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045632">
        <property type="entry name" value="DUF6314"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19834">
        <property type="entry name" value="DUF6314"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6314" evidence="5">
        <location>
            <begin position="571"/>
            <end position="750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4044350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="750" mass="81808" checksum="04AADCB7FE00FB2A" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PTY5</accession>
    <name>A0AAN6PTY5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Pre-mRNA-processing protein prp40</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_12037</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854318">
        <property type="protein sequence ID" value="KAK4044530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PTY5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.440:FF:000032">
        <property type="entry name" value="Formin binding protein (FNB3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.440:FF:000033">
        <property type="entry name" value="Formin binding protein (FNB3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000078">
        <property type="entry name" value="Formin binding protein (FNB3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.440:FF:000013">
        <property type="entry name" value="pre-mRNA-processing protein 40A isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.440">
        <property type="entry name" value="FF domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002713">
        <property type="entry name" value="FF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036517">
        <property type="entry name" value="FF_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039726">
        <property type="entry name" value="Prp40-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11864">
        <property type="entry name" value="PRE-MRNA-PROCESSING PROTEIN PRP40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11864:SF0">
        <property type="entry name" value="PRP40 PRE-MRNA PROCESSING FACTOR 40 HOMOLOG A (YEAST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01846">
        <property type="entry name" value="FF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25432">
        <property type="entry name" value="FF_PRPF40A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00441">
        <property type="entry name" value="FF"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81698">
        <property type="entry name" value="FF domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51676">
        <property type="entry name" value="FF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="WW" evidence="7">
        <location>
            <begin position="6"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="7">
        <location>
            <begin position="52"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="FF" evidence="8">
        <location>
            <begin position="152"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="FF" evidence="8">
        <location>
            <begin position="221"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="FF" evidence="8">
        <location>
            <begin position="368"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="89"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="544"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="90"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="546"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="600"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="644"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="792"/>
            <end position="812"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4044530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="846" mass="99328" checksum="6D2D512DA98C97A1" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SL05</accession>
    <name>A0AAN6SL05_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Topoisomerase II-associated protein PAT1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_41270</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">P-body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PAT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854626">
        <property type="protein sequence ID" value="KAK4032291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SL05"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033962">
        <property type="term" value="P:P-body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039900">
        <property type="entry name" value="Pat1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019167">
        <property type="entry name" value="PAT1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21551:SF0">
        <property type="entry name" value="PROTEIN ASSOCIATED WITH TOPO II RELATED-1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21551">
        <property type="entry name" value="TOPOISOMERASE II-ASSOCIATED PROTEIN PAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09770">
        <property type="entry name" value="PAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="mRNA decay factor PAT1" evidence="8">
        <location>
            <begin position="1"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="103"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="167"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="531"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="178"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4032291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="856" mass="94610" checksum="583F4D92C0E155A8" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SL09</accession>
    <name>A0AAN6SL09_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_51632</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU855024">
        <property type="protein sequence ID" value="KAK4031182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SL09"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="290"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4031182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="392" mass="43253" checksum="AB5DD7F9D1035CE1" modified="2024-10-02" version="1">MAIALTKVAGGTAAGILTYSFVCLAFGLSLLWLAWVHTEYKSYVGLLSFFVSLHTLASIAQQIYTIVRWRDIKFDQYNYLVAHIDDPQLSSQNTMTGLVRALFYIQYYSYNVESLLLANSIFQVHVFSAWRFHASLIAKAVAALLPIVQVMLLNLAPVRRSKAGYIVLSIGIMTFCFGVGTLVLFAILARYLHSRITLATWSVRYGRSMGSTNKTGNGTGTDPARRAPRRSNIYDKWLVLRFSIGFAALALFQLVVITYQLRSSNANNAASIPPEPDLSASHAKSDFAEFPPAVTACIVIFLVFGTTRTFREYMWHLFVPGAVGWKAAREKQPTAAAAGGSVSVVHSAAGRELETGNAGAILTLDDLPRRGLEGKSDEIVRRGENWFLHKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SLD4</accession>
    <name>A0AAN6SLD4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_20928</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the NRP synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854675">
        <property type="protein sequence ID" value="KAK4031934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19537">
        <property type="entry name" value="C_NRPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF11">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="7"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="1078"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1062"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1063"/>
            <end position="1082"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4031934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1670" mass="180939" checksum="4A9CF4271F34C2E3" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SLD9</accession>
    <name>A0AAN6SLD9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_20913</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854673">
        <property type="protein sequence ID" value="KAK4031949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1452"/>
            <end position="1474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1495"/>
            <end position="1519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1531"/>
            <end position="1560"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="96"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="609"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4031949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1620" mass="179771" checksum="47C8A4F7F1146728" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SLI8</accession>
    <name>A0AAN6SLI8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_41789</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854705">
        <property type="protein sequence ID" value="KAK4031767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SLI8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042996161" description="Secreted protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4031767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="109" mass="12870" checksum="C2E7329CFFC41C43" modified="2024-10-02" version="1">MKALILVKRLRLCHVLVRLPCLLSTFPLHKQFQAAVIQPPVATDLLYQELFLPAVVANHWGERPRTVVNMTSWFMHRDPVAFPDPETFDLERWLDVKRAHFRDKFLLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SLK5</accession>
    <name>A0AAN6SLK5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_51226</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the Nibrin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854695">
        <property type="protein sequence ID" value="KAK4031828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SLK5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030870">
        <property type="term" value="C:Mre11 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10980">
        <property type="entry name" value="Nibrin, BRCT2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040227">
        <property type="entry name" value="Nibrin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032429">
        <property type="entry name" value="Nibrin_BRCT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043014">
        <property type="entry name" value="Nibrin_BRCT2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12162:SF0">
        <property type="entry name" value="NIBRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12162">
        <property type="entry name" value="NIBRIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16508">
        <property type="entry name" value="NIBRIN_BRCT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="7">
        <location>
            <begin position="16"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="356"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="426"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="593"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="631"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="437"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="601"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="638"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="661"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="671"/>
            <end position="704"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4031828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="730" mass="82586" checksum="6EFBCAB81B5E07CF" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SLU4</accession>
    <name>A0AAN6SLU4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Alpha-L-arabinofuranosidase</fullName>
            <ecNumber evidence="11">3.2.1.55</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">C8A01DRAFT_50800</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Alpha-L-arabinofuranosidase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>Hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides.</text>
            <dbReference type="EC" id="3.2.1.55"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the glycosyl hydrolase 62 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.55" evidence="11"/>
    <dbReference type="EMBL" id="MU854614">
        <property type="protein sequence ID" value="KAK4032399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SLU4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046373">
        <property type="term" value="P:L-arabinose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005193">
        <property type="entry name" value="GH62_arabinosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40631">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE AXHA-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40631:SF1">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE AXHA-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03664">
        <property type="entry name" value="Glyco_hydro_62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 11 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 11" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0858">Xylan degradation</keyword>
    <feature type="domain" description="CBM1" evidence="13">
        <location>
            <begin position="278"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="258"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="258"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK4032399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="314" mass="34480" checksum="6E8DEC405770A4C7" modified="2024-10-02" version="1">MKLLNMDLSPVTALTVALLASIKSLKDFTHVPYKGQHLVYGSFFAPKPGPGWSSFNFGLFSDWSQVGKASQNAMRFSTVAPTLFFFAPKNTWTLIADDTHMYLFFAGDNGKIYRSRMPIGNFPSSFGNQYDTIMSGATGDLFEAIQVYKVKGQNQYLMIIESIGARRRYFQSYTATRLDGAWTPQATSEDRPFAGRANTDAGAAWTNDISHGDIIRSNPDQTFEIDPCNLQMLYQGRTGDSNNYDLWHYMPALLTLEGAGGGSPGTPGGNPDPGSPRGSVKHFEQCGGTGYGGPTNCESPFKCTVFNPYYSQCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SNY5</accession>
    <name>A0AAN6SNY5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mannosyltransferase</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">C8A01DRAFT_38134</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the eighth mannose residue in an alpha-1,6 linkage onto Man(7)GlcNAc(2)-PP-dolichol to produce Man(8)GlcNAc(2)-PP-dolichol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate = an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29535"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="Rhea" id="RHEA-COMP:19518"/>
            <dbReference type="Rhea" id="RHEA-COMP:19519"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:132517"/>
            <dbReference type="ChEBI" id="CHEBI:132519"/>
            <dbReference type="EC" id="2.4.1.260"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:29536"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the glycosyltransferase 22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="EMBL" id="MU854445">
        <property type="protein sequence ID" value="KAK4035396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SNY5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052917">
        <property type="term" value="F:dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760:SF1">
        <property type="entry name" value="DOL-P-MAN:MAN(7)GLCNAC(2)-PP-DOL ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="180"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="308"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="338"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="362"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="403"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK4035396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="669" mass="71090" checksum="10F84483ABA5EB3C" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SP44</accession>
    <name>A0AAN6SP44_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Biotrophy-associated secreted protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_49229</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854482">
        <property type="protein sequence ID" value="KAK4034378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SP44"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043006216" description="Biotrophy-associated secreted protein 2" evidence="1">
        <location>
            <begin position="19"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4034378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="99" mass="9594" checksum="91F9F84E731713E7" modified="2024-10-02" version="1">MVRLTIAALLIFALAATAITPNNAGAKNVGAGNGGQFITGGCVNNADCGSDCCADASGVGVCSAEAAQFQNGKNGCGFVDPNAAATIAAAKAQVQKQGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SP70</accession>
    <name>A0AAN6SP70_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_18626</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854472">
        <property type="protein sequence ID" value="KAK4034617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SP70"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF181">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="319"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="356"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="404"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="440"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="465"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="501"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="65"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="262"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4034617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="537" mass="58342" checksum="548C7A1265DE454C" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SPK5</accession>
    <name>A0AAN6SPK5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_18246</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854457">
        <property type="protein sequence ID" value="KAK4035037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SPK5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12087">
        <property type="entry name" value="TM_EGFR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="365"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4035037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="387" mass="41460" checksum="B403A75236A05483" modified="2024-10-02" version="1">MRHRRRSSLHLGLSPKKTNKRDGEASLENDGIEDDNRPGLGKGRGKGKGDPSNFLSDLPISELFPTSSLVQPPPLSETRGLSTTSSLLEPETPQSTSPPPPPVSETVSPSDSATTHIESTQYSTTTTSNALPVQAFSVSNGPSPGQIAGIVVGSLAFLIFAITSAFFLLRRHRRGTNQDWGSASSLFGRIIAKPLTPPGSHQEIEKSPLTRGAHKFGTANTQPKPAAAAARLSNWLSQFRHSHLPPQEPQSPRQVINPTSTISTAHVMDPSDTDSSSILSLPTTFVTRHTNSTFLPTTALHHPRYVAPAAQQQGNVEPPASPLGIGMGRNRDSQFINERRREEYLHPTSASGFLEPLPPIPAAARLSGIGHGGGEEGYVKVQVRRPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SPM6</accession>
    <name>A0AAN6SPM6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_47972</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854430">
        <property type="protein sequence ID" value="KAK4038404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SPM6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140115">
        <property type="term" value="P:export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042908">
        <property type="term" value="P:xenobiotic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF51">
        <property type="entry name" value="QUINIDINE RESISTANCE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="348"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="437"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4038404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="472" mass="50855" checksum="F17172F52A6D037D" modified="2024-10-02" version="1">MANDATPGPATLPTEITERYSSFSRRQQNTIIGLAALGGWFSSISSFIYFPAIPFLTSYLIMSGIFPSIMGDAADRFGRRPVFLVALVVDFGANIGLALQSHFVLLFVFRMLQSAGISGTFSTAYGILGDLFTPAERGGYSGIIAFFLNTPPSLGPVLSGLLLLRWTWRSIFWLLAVSSALCLAVMAPFLPEMARSIVGNGSSPAKSINKALVPLMSPKKTQAAESSPAAPPREESRKFPNPLAALKLLRIPGTAIILLTYGINYTVYCCLQASLSTLFVNIYHVSGLVAGLVYLPFGVAVALSDLATGRLLDFNYKRTAAESGINVKEREATDLNNFPIECARLRTVNLRVALSAVLVVGYGWALQARVSMAAPLVLQFLIGLTIQVVFTALNTLLVDLHPECRSTAQAACNFVRCEMAATCLAGLDAMIQRLGPGWSFLLFGATLGLEFLMLLLVQLRGMKWRCSGPQGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SPQ4</accession>
    <name>A0AAN6SPQ4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MPN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_18289</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M67A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854459">
        <property type="protein sequence ID" value="KAK4034980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SPQ4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08069">
        <property type="entry name" value="MPN_RPN11_CSN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000001">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050242">
        <property type="entry name" value="JAMM_MPN+_peptidase_M67A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056263">
        <property type="entry name" value="RPN11_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10410">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23594">
        <property type="entry name" value="RPN11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102712">
        <property type="entry name" value="JAB1/MPN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="9">
        <location>
            <begin position="33"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="313"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="321"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4034980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="623" mass="68208" checksum="ADB99DFABA872672" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SQ37</accession>
    <name>A0AAN6SQ37_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_48310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854442">
        <property type="protein sequence ID" value="KAK4038016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SQ37"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF37">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4038016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="447" mass="49370" checksum="CBD1B54F066431BF" modified="2024-10-02" version="1">MVSAQSSKTLPSSRWTSLDSWDYNGMQERLQTLLFKLDKSVLLRHAESVTGQRLTMSEPFSAGQYWICFELVAEDGSLVIARVRLPRHPDLPSTVTEKDELYSISCEVSTMQFVSRNPPTVTIPRVYAYEGPGSQLAADAGAIYMLLEGFYGNTLQDVAFDICSLPVATQEHIMAQWATVQAELATLTHSQIGTICSASEQGEPVIGKLSSAAAEGLSNLGPFSSAVDYFTAIAEAALHKPHPSTNGHSNKDWTSLARLGALVLLDIIQTTQLFTSSPDAQFPLNHMDLGTQNILVDDAFNFLAVIDWKFAQTAPWQVNYYPMPFPLIWSGEKIKEALENPEHLAHKNVSRQVAARGVYVEKFREAEDKLRREGRPMVGGSFADVLESAASRVYGCFCRLRGVPEQDEELVWEMVRVAFEFGDGGMEEYLGAMKGRLRETGGLNGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SQ95</accession>
    <name>A0AAN6SQ95_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Proteasome regulatory subunit C-terminal-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_48062</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854433">
        <property type="protein sequence ID" value="KAK4038300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SQ95"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042176">
        <property type="term" value="P:regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050756">
        <property type="entry name" value="CSN3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013586">
        <property type="entry name" value="PSMD3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057985">
        <property type="entry name" value="TPR_PSMD3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758:SF2">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3/COP9 SIGNALOSOME COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08375">
        <property type="entry name" value="Rpn3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25573">
        <property type="entry name" value="TPR_PSMD3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="4">
        <location>
            <begin position="329"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="161"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="557"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="18"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="177"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="557"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="568"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4038300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="583" mass="64719" checksum="F3AC50D95DB75FBD" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SQB2</accession>
    <name>A0AAN6SQB2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Mitochondrial fission 1 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">C8A01DRAFT_48107</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Has a role in mitochondrial fission. Has a role in outer membrane fission but not matrix separation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">The C-terminus is required for mitochondrial localization, while the N-terminus is necessary for mitochondrial fission.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the FIS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854435">
        <property type="protein sequence ID" value="KAK4038226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SQB2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12212">
        <property type="entry name" value="Fis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000179">
        <property type="entry name" value="Mitochondrial fission 1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016543">
        <property type="entry name" value="Fis1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033745">
        <property type="entry name" value="Fis1_cytosol"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028061">
        <property type="entry name" value="Fis1_TPR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028058">
        <property type="entry name" value="Fis1_TPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13247:SF0">
        <property type="entry name" value="MITOCHONDRIAL FISSION 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13247">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 11 TPR REPEAT PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14853">
        <property type="entry name" value="Fis1_TPR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14852">
        <property type="entry name" value="Fis1_TPR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008835">
        <property type="entry name" value="TPR_repeat_11_Fis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 12" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR008835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK4038226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="153" mass="17017" checksum="1267A05122A5251C" modified="2024-10-02" version="1">MTQLPYAIDAETSLNPAELEVLRAQYEREGDMVGVQTKFNYAWGLVKSSTRHEQHLGVMLLSEIFRTSAERRRECLYYLALGNYKLGNYGDARKYNDLLLDKEPGNLQATNLRSLIDDKVAKEGLMGVAIVSGVAVVAGIVGGVLLRNLGRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SQG3</accession>
    <name>A0AAN6SQG3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">chitinase</fullName>
            <ecNumber evidence="1">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_47632</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="1"/>
    <dbReference type="EMBL" id="MU854418">
        <property type="protein sequence ID" value="KAK4038827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SQG3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000159">
        <property type="entry name" value="Class V chitinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF378">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042884429" description="chitinase" evidence="2">
        <location>
            <begin position="21"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="3">
        <location>
            <begin position="29"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4038827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="392" mass="43529" checksum="698F47434E623FF5" modified="2024-10-02" version="1">MAPTRLLWSLFLCFVSFSMAVNLTAKRDLRCIMYFTGQHPVAPPMDQLRHVTHVAVAFMSPGIFNEPGRTDWPLFTTVKDVRAKFPEETKVQVAIGGWGDTIGFSVAALNDETRKTFAENVANMVAATGADGVDVDWEYPGGNGEDYKQVPNSAKAWEISAYPLLLAELRAALGPDKIISAAVPGLKRDMLAFTRETVPRIMRHVDFLNVMTYDLMNRRDTVTKHHTGVDLSLETVDAYVSAGAAPQKLNLGFAFYTKYFKTEHDACALTSPVGCPTLQLEDPETGEDLGRGGGFSWHDSVPEDVASSFARALDHGVYDDQQGGYYYWDAMDDLWWTFDTPDAIKRKFPLIMAKRRLGGVFAWGLGEDAPLFKHFTALSDGLEEHLKGKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SQL2</accession>
    <name>A0AAN6SQL2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pentatricopeptide repeat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_17466</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854429">
        <property type="protein sequence ID" value="KAK4038438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SQL2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447">
        <property type="entry name" value="OS03G0856100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447:SF17">
        <property type="entry name" value="OS12G0638900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="648"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="797"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="648"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="671"/>
            <end position="688"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4038438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="861" mass="96648" checksum="3C9F5A153DA358E0" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SQQ6</accession>
    <name>A0AAN6SQQ6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MHYT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_47780</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854423">
        <property type="protein sequence ID" value="KAK4038646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SQQ6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005330">
        <property type="entry name" value="MHYT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35152">
        <property type="entry name" value="DOMAIN SIGNALLING PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G11310)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35152:SF1">
        <property type="entry name" value="DOMAIN SIGNALLING PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G11310)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03707">
        <property type="entry name" value="MHYT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50924">
        <property type="entry name" value="MHYT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="93"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="162"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="MHYT" evidence="3">
        <location>
            <begin position="21"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="757"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="811"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="828"/>
            <end position="839"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4038646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="897" mass="97169" checksum="0AE2491C741AEEFD" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SQQ8</accession>
    <name>A0AAN6SQQ8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_16875</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854410">
        <property type="protein sequence ID" value="KAK4039112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SQQ8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42044:SF2">
        <property type="entry name" value="DUF676 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42044">
        <property type="entry name" value="DUF676 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4039112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="461" mass="50819" checksum="15C29BE3BA8E12A4" modified="2024-10-02" version="1">MLVDAIQFAQWSTTSAAKWVVAGLGDPNAIVDGAEKIFNKARDDEHRQLLRVVLSWLLISGMLRHANPATLLEFTASIVETTLAALLQNVGQLPIIRHGILSNSVNAPTLELVWGQRAELVSFLVDIIECAKCFVPANGRPAPDPQALRVEYNELDVSKPENRHAIICQLQRLAKSVVAILRTSAHGDGLPEIIMREEDTRLDTDTDRIGTTPNDLIRVASGSSPPRRKQHWLFVNGIGGEYHWLDLACKKLKERFGRNTVGVFNRGDGILWDLVECAGERSHREQGNTTSKDNLIQRTASSMEAQALLGESLGLMLQQAGPDAVVVAHSQGCLLLRLVLEDLANTDDKKIHKQMEDNLCVFTFGNPSIHWKVENRPDVALASYSCRTEHFANNTDFVAKLGVLSDETGGDNGYSNVFVNESWKGHLFGAQYSLDDGDYNGGHESWLLNCRNAHQPIGPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SR72</accession>
    <name>A0AAN6SR72_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_16895</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854411">
        <property type="protein sequence ID" value="KAK4039083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SR72"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF10">
        <property type="entry name" value="ABC TRANSMEMBRANE TYPE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="71"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4039083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="452" mass="48991" checksum="1CC090EE76241ED9" modified="2024-10-02" version="1">MDPDDSSLNPPLPPPPSTGSVSRPSSSSTHIAVDMHSTPEENLYAAAQAMREGIMRGTSRSKSRAKDKGKAAATTTTATTSPPPSASASSIAHPTTAASSSSSSSSSSTSSTTNSQPASNPASEAAAAVPEGGEGGGTPPFTFDKDMARYPASMTSSVRDHVYEGGLRYHAYRAGKYAFPNDEVEQNRDDMKHTMTLMLCRGAYFYAPVEGVLEEGGEVLDLGTGTGIWAMELGDKYPNTTITGIDLSPIQPTFVPENVHFFVDDFEEEWVDPEDKYDFIHLRHTLHSVQDPPALLDRAICHLKPGGYFEAQELAVQPQADDDTLTPETPYALRDYINYMAAGMRILGSNVHAIGDLPEQMRAAGFQDVRKTTHKCPVGVWPRDKRLRFCGLFLRTALMDGLRGLSRRPLTALGWTPLQIEIFLVEVRKAIMEAGVHAYLVLHVVHGRKPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SRP1</accession>
    <name>A0AAN6SRP1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_35388</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854373">
        <property type="protein sequence ID" value="KAK4040624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SRP1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40368">
        <property type="entry name" value="YALI0F14399P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40368:SF1">
        <property type="entry name" value="YALI0F14399P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042979617" evidence="2">
        <location>
            <begin position="25"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4040624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="299" mass="32673" checksum="4264BB6F13A3A499" modified="2024-10-02" version="1">MTFLPLQLRLLVLVAASLVATALAAAGHENSLPSYHYGAPIRVECMNRSSETGEHIENAQHEIQWIPFPVCNETNQPLEFHYGIEGEQNCTIAMVSDPFFHLLEFYIHNDAPLSCRLPARPAPHVQVVGEKLPEQEYIPLVFALAGTLQLSHMHISTHLNVLLHSTPKHHIQPRDSGVLDSGTAYSTSPLTHLEGSATRRLVIGDPLPLSFSVRWFPTPALPKVAGKVEWSGMGGHIYASTVFYSLVSFCAGVVVAAVYFFGSVLPRRLRGRGLGGATPLGYGMNGVGNGWGYQKRAMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SRP5</accession>
    <name>A0AAN6SRP5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_16471</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854397">
        <property type="protein sequence ID" value="KAK4039563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SRP5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042968918" description="Secreted protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4039563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="109" mass="12402" checksum="5D79360B2650B2BF" modified="2024-10-02" version="1">MRLPTLAVLASVVPIVAADYMLVLTSCLNGRCGSQGWWTTVEDTYWVDANEGCRDPDVPSMWSLCMDWGNQRGHFFFEGQPKRCIRKVSEGWAEYGMTSSNWDEVPCTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SS02</accession>
    <name>A0AAN6SS02_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_16181</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854389">
        <property type="protein sequence ID" value="KAK4039863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SS02"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4039863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="186" mass="20813" checksum="44D2399D1CE11249" modified="2024-10-02" version="1">MVTHISIDTLLEPPTASVRPYPHHCQDLALQKYLLLHEQHESLRQHLDELRPSARQTSLCTPVSPSPATSPTTRMRMSFSPGAPRRRQPPPQHTFSLPARNGASSSSSSSSYHDHEETSAAEVVAVEEAKLCDVNEGIKRALTELLNCETVRGDRAFRTWVQCRLMDTERELRSGRRRRSAPGLGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SSA7</accession>
    <name>A0AAN6SSA7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_45950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854370">
        <property type="protein sequence ID" value="KAK4040747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SSA7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4040747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="428" mass="48939" checksum="A5EC914B98ED8D18" modified="2024-10-02" version="1">MDFLPVELVRLVFQYCDAPTVRALRLAAGRYADVGYEYLLDSHFNAVEWRDDISRLRSIAGHDRLRGSIRFLTFNFSKVDEYNARHTTFFQHWLQEPEERSALLQDSWIRYYELEENARKLPPFNARSSAVEEAFKRLPNLKDLEITLTKCPYDIPLLQEVFQVRTCRKRDRVQACKNMNAIVSATRHVRLASLSIDQLPLEIFRLADDRRHWFDCARSFASLSRLSLTLDPPANLLPSARFRAVNGLGHVLHYSVNLTHLTLAFHNYHAPSHKFHLSFQALFCGSDFTYPKLTDLKLEGVSCAEEDLKGFILRHGATLERLRLGGRGLAKPSEWSMGGVHLHEGSFRGLFTGLRKATAGGKMLALKRFHMEGDAEAGDFMASSREVYVFRPVTDDEWVPTVDCLGLERFLVEGGEYPRLGKEVADGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SSK5</accession>
    <name>A0AAN6SSK5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7721 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_34409</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854355">
        <property type="protein sequence ID" value="KAK4041569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SSK5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056138">
        <property type="entry name" value="DUF7721"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39477:SF1">
        <property type="entry name" value="BETA-FLANKING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39477">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24845">
        <property type="entry name" value="DUF7721"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7721" evidence="2">
        <location>
            <begin position="43"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4041569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="214" mass="21797" checksum="BBADD599C8E5E290" modified="2024-10-02" version="1">MDKLLGKAVDKVFGDDDERPQGGNVTHGGAYPAGGGYPHADDDIRGAASVAASEAPEDHDFFAGVLGKLLQDKPQAKIAEEDIDEEDAVQSHRKFFDTLGGASTTNSEPASSSSLGSAAAMQALKLFTSGESSSTPQSQSQNAFVGLAMAQAAKLFDAQASQGNVAAGADKQSVVMKAGEVALKMYLKSRGGGQAGAQAGGMEGLMGLAGKFIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6STF3</accession>
    <name>A0AAN6STF3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_34024</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854349">
        <property type="protein sequence ID" value="KAK4041917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6STF3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042998834" evidence="2">
        <location>
            <begin position="19"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4041917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="75" mass="7637" checksum="F77C8AFDB2DE29BF" modified="2024-10-02" version="1">MRPITTLLLSLLAPTALGLAVPSPKNAGELSAPKRSLPAAAVVDRSPSVEGAGKSGGDDDDAIAYAWYDEDGEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SU04</accession>
    <name>A0AAN6SU04_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_14329</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854347">
        <property type="protein sequence ID" value="KAK4042008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SU04"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="125"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4042008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="239" mass="25171" checksum="77D4081B6951249C" modified="2024-10-02" version="1">MDRPNPDEIDLFDDDDFNESNESNDIQVAEDPAMAAVLGFTSFGGTKPTDDDDNGNDGSRPSKKRRFNPHSDNAVIATDEPPLIKGKPQPPKDEITYSDSDNNDFELDVTARPAEFDSDAPPTPSGTSTPALAAASQSQPTGTRPQNGRGAQSGRGGNRGGGGARGGGAGRGGPHNPLWYVDYYDASSNENPWEGMEKFKGLEAVGTWLSRLWDREKKEKGEGASGVEGGGEGVAATAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SUG2</accession>
    <name>A0AAN6SUG2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_33444</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854340">
        <property type="protein sequence ID" value="KAK4042503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SUG2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4042503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="116" mass="13194" checksum="7E3CB03DA7F08909" modified="2024-10-02" version="1">MSKLFRRRHSAPRPLLDPSAYSSLLDPSISAQDQPGGHSRGRTSPADYHSRPWLAAAEVRPSWNGERPPTRKLVKDMNGSGRPSFSLELSDSDNEKDKGVVRRQLARLRELYRREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SW29</accession>
    <name>A0AAN6SW29_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Polyamine aminopropyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_12278</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854320">
        <property type="protein sequence ID" value="KAK4044213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SW29"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010487">
        <property type="term" value="F:thermospermine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006596">
        <property type="term" value="P:polyamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000288">
        <property type="entry name" value="Spermine/spermidine synthase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF037959">
        <property type="entry name" value="MFS_SpdSyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43317">
        <property type="entry name" value="THERMOSPERMINE SYNTHASE ACAULIS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43317:SF1">
        <property type="entry name" value="THERMOSPERMINE SYNTHASE ACAULIS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01564">
        <property type="entry name" value="Spermine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="125"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4044213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="603" mass="64505" checksum="17D9554F8A2DD1A5" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SW35</accession>
    <name>A0AAN6SW35_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Dihydrodipicolinate synthase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_12258</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DapA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854319">
        <property type="protein sequence ID" value="KAK4044390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SW35"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00408">
        <property type="entry name" value="DHDPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128:SF52">
        <property type="entry name" value="4-HYDROXY-2-OXOGLUTARATE ALDOLASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="2">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4044390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="344" mass="36730" checksum="D5B9B97B9A1A8A98" modified="2024-10-02" version="1">MESPPQPITPTTPTHLPSTQQPPAPLPKGVYVPMPAFFHASDNDAIDIPATQRHTARLLAAGITGLVVHGSNGEAVHLSRRERRAIIEAVADAVRHETDSHVPVPIIAGCSAQSVRETLELCREAKDAGATHALVLPPGYYRGLMDSDGVVGYFERVAEGSALPVVVYNFPAAANGVDLDSDVLLRLAGNPRVVGVKLTCGNTGKLARLVEGAPRVRGCREDFFVGGGSADFILQGLVAGAHGTISGFANLAPRACVRIGELYEQGRLKEARELQHEVAKGDWLAIRYGFVGVKAAMPIFHGPAEASCAVPRLPFKRLEEDGQAVREIREGMARVLEIERKLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SWJ4</accession>
    <name>A0AAN6SWJ4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Prephenate dehydrogenase [NADP(+)]</fullName>
            <shortName evidence="9">PRDH</shortName>
            <ecNumber evidence="9">1.3.1.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">C8A01DRAFT_11986</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 9">
            <text>prephenate + NADP(+) = 3-(4-hydroxyphenyl)pyruvate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:21640"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="ChEBI" id="CHEBI:36242"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.3.1.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8 9">Amino-acid biosynthesis; L-tyrosine biosynthesis; (4-hydroxyphenyl)pyruvate from prephenate (NADP(+) route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the prephenate/arogenate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.13" evidence="9"/>
    <dbReference type="EMBL" id="MU854317">
        <property type="protein sequence ID" value="KAK4044708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SWJ4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008977">
        <property type="term" value="F:prephenate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004665">
        <property type="term" value="F:prephenate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006571">
        <property type="term" value="P:tyrosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3660.10:FF:000002">
        <property type="entry name" value="Prephenate dehydrogenase [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3660.10:FF:000004">
        <property type="entry name" value="Prephenate dehydrogenase [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000339">
        <property type="entry name" value="Prephenate dehydrogenase [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3660.10">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046825">
        <property type="entry name" value="PDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050812">
        <property type="entry name" value="Preph/Arog_dehydrog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003099">
        <property type="entry name" value="Prephen_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012385">
        <property type="entry name" value="Prephenate_DH_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21363">
        <property type="entry name" value="PREPHENATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21363:SF0">
        <property type="entry name" value="PREPHENATE DEHYDROGENASE [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20463">
        <property type="entry name" value="PDH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036510">
        <property type="entry name" value="PDH_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51176">
        <property type="entry name" value="PDH_ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 9" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="4 9" id="KW-0521">NADP</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0827">Tyrosine biosynthesis</keyword>
    <feature type="domain" description="Prephenate/arogenate dehydrogenase" evidence="10">
        <location>
            <begin position="10"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00051295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00060605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR036510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK4044708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="439" mass="49339" checksum="0CC3FE780543D41B" modified="2024-10-02" version="1">MATFPGAEDFVIGLIGMGDMGKMYARRLSSAGWRIMACDREDKYDELVAEFANHKNIQILRNGHLVSRASNYIIYSVEAAAISRVVAQYGPSTRLGAIVGGQTSCKDPEIKAFEEHLPTDVDIVSCHSLHGPNVDPRDQPLVLIKHRASDASFAKVETVLRCLGSKHVYLTAREHDRITADTQAVTHAAFLSMGKAWHANQQFPWEGTRYVGGIENVKINLMLRIYAQKWHVYAGLAILNPEAHKQINQFAKSTTELFYLMLEGRSAELRERVYAAKEKVFGREASPKWGDKPLLPDGVVDRFSLNANAKNNAPPMPNNHLSLLAMVDCWSALGIVPYDHMICSTPLFRLWLGVTEHLFRTPGLLDESLRVGIEDNTFRRDDLQFTIAASGWAECVALRQFETWRERFAVTQKFFEPRFEGAVEMGQAMIKAVLESEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P410</accession>
    <name>A0AAN6P410_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_42322</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU855007">
        <property type="protein sequence ID" value="KAK4031195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P410"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053018">
        <property type="entry name" value="Elsinochrome_Biosynth-Asso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37577">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37577:SF1">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="273"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="403"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="509"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="539"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="618"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="445"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4031195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="664" mass="73973" checksum="86BE0A9F422783F8" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P4A7</accession>
    <name>A0AAN6P4A7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_21280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854782">
        <property type="protein sequence ID" value="KAK4031504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P4A7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="126"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4031504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="321" mass="33616" checksum="58B7A86D2D43893A" modified="2024-10-02" version="1">MNRHALRSALGRATPSTTARALILPVSTTTPTSFFSTTASRPDDANSNSSGNKPRSQSAAVSRLSQLNNNSSFGGGGGGGERRSALDSIPGLSSSSSSSFSRGPIGPRRGGARGGGGIDARSLRVSPDASGPSSSGSGPRLVWTPEEKEVIDRLEKGDMVPFDPKVTLDSLTGYGAAMATDAPIGQVETALRAMRLMTGGMAFNPESGVTADVKDIMKKYRAKKPIFVHSKEEKAWIESAQPRLRLVGPDAGTKKAIIEPAILGKYEATKFAEAGDVAATMANYHARTFTYMASDSQKFMDKVLSLLPAQQGGRPAAQAKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P5S2</accession>
    <name>A0AAN6P5S2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">96ca82bc-67f3-4b3a-ab36-ffe7d8f40fbe</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_41366</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854636">
        <property type="protein sequence ID" value="KAK4032199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P5S2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF42">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="65"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="223"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="47"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4032199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="327" mass="36035" checksum="3B4262B1D8F2473A" modified="2024-10-02" version="1">MGPHGLVPRQSPSAQPVDDGLSHEDLGPRLNTVFWLLTSLATLFLALRIYCKFHRGRNLWWDDHFLIAAWVSLVVSAATTSVCVSLDYGKNSYDMRPEVSTQMQFVAVFAGFFSVLAAAWSKTSFALTLLRLSQGWMKALIWFIIVTMNIIMGTAMLFMWIKCRPFARVWDTSLDGWCIDPAIIVTLYQWSAGWSGSADIVLALLPWGILFGMRHSLNTRERLGVAIAMSMGVLAGVASIVKLVMLPNLRGDPTDTVSVTIWGGAEGAITIIAASIPVLRALIRGDKGRSTARFDTIDERQLNTASLETLSPTRKGGNYVDMYSPVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P6G8</accession>
    <name>A0AAN6P6G8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Chitin-binding type-4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_50609</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the polysaccharide monooxygenase AA13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854588">
        <property type="protein sequence ID" value="KAK4032643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P6G8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004302">
        <property type="entry name" value="Cellulose/chitin-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052282">
        <property type="entry name" value="Starch-active_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36575">
        <property type="entry name" value="BINDING PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G14430)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36575:SF2">
        <property type="entry name" value="CHITIN-BINDING TYPE-4 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03067">
        <property type="entry name" value="LPMO_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0186">Copper</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042965645" description="Chitin-binding type-4 domain-containing protein" evidence="7">
        <location>
            <begin position="21"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-4" evidence="8">
        <location>
            <begin position="49"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4032643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="188" mass="20004" checksum="59C4519C33F391F7" modified="2024-10-02" version="1">MAATLVRLITVAAAAAGVLGHAVVKVPTPRGSGSAYTERCGETYAVYMEKDKAGPIENGVKQAGSALGCNAFLCRGYQYEDNTATDYTAGQVIDFHVDLIAGHHPGYANVSVVDLATNKVIGDPLRSWDDYPNATATTPRSDINFNVTIPSTLGEACSTGGKCAIQWYWYASGNKQTYESCVDFYVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P6P0</accession>
    <name>A0AAN6P6P0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_40809</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854579">
        <property type="protein sequence ID" value="KAK4032746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P6P0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4032746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="364" mass="39414" checksum="AEEC7A9252BA1619" modified="2024-10-02" version="1">MTKKKAARANAAKKKANANAKTNAPKATGTHFTPAPLSGPVPESLAAEASEASNAHLDAFQRRMIKQLRVLAAGALSRRLPESDGRNSGNPAMTADELRRRVKTRILELEETSNQMAALHKKLEPKGRVHIDELKQLVDAIPLKFQSFPEICEALRARELEKGEDAGDKERAKYREAQAEVPDGDIDKNRIMDVDVAPPVTEVSAPAAAGSNPPMNPLFLPPTTTTTPAQLPKSLAAIPGSREMFASLNAGMDALERGLAERRNILAALDLQGNSVASDRSSYHGKVTSTAEELARRVEDSLVTLEEISSRRAASGNKLGHGELNSNNIRKGTQLYVLLAALFSGEMVEQEFGARLRDMDKDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P7L0</accession>
    <name>A0AAN6P7L0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_20992</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854690">
        <property type="protein sequence ID" value="KAK4031853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P7L0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="508"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="108"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4031853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="550" mass="62401" checksum="FB3C347166020774" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P8M0</accession>
    <name>A0AAN6P8M0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_49733</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854512">
        <property type="protein sequence ID" value="KAK4033754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P8M0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015203">
        <property type="term" value="F:polyamine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010509">
        <property type="term" value="P:intracellular polyamine homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000172">
        <property type="entry name" value="MFS multidrug resistance transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF5">
        <property type="entry name" value="QUINIDINE RESISTANCE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="216"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="252"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="281"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="360"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="401"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="451"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="481"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="512"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="539"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="125"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="51"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4033754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="579" mass="62726" checksum="183727ACB648B45A" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P8R6</accession>
    <name>A0AAN6P8R6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">tRNA(m1A58)-methyltransferase subunit TRM6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_20488</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRM6/GCD10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854610">
        <property type="protein sequence ID" value="KAK4032438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P8R6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031515">
        <property type="term" value="C:tRNA (m1A) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017423">
        <property type="entry name" value="TRM6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12945">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12945:SF0">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE NON-CATALYTIC SUBUNIT TRM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04189">
        <property type="entry name" value="Gcd10p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="287"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="298"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="333"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4032438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="612" mass="67324" checksum="52617D335D39101E" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P8Y8</accession>
    <name>A0AAN6P8Y8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_41588</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854668">
        <property type="protein sequence ID" value="KAK4031971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P8Y8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4031971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="85" mass="8935" checksum="E79566F61A022FCD" modified="2024-10-02" version="1">MAIFGSIVAGYMQDRLGRRAVFLLAVIFAAAGIAANFVANNPAQFLSGKIITGFANLGFLIAISSTFSRVSIMDKSAFRVLFAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P9N9</accession>
    <name>A0AAN6P9N9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Heterokaryon incompatibility protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_50045</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854535">
        <property type="protein sequence ID" value="KAK4033365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P9N9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF82">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26639">
        <property type="entry name" value="Het-6_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="539"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="575"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="47"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4033365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="711" mass="81209" checksum="F806D21B0CE528D1" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PAR0</accession>
    <name>A0AAN6PAR0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_38602</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854461">
        <property type="protein sequence ID" value="KAK4034906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PAR0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043021774" evidence="2">
        <location>
            <begin position="17"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="283"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4034906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="328" mass="34124" checksum="E977BA48A0897E47" modified="2024-10-02" version="1">MRAALSLVALAATALAANIPLRGERGLVDRTYGHDKPDKGKSDEDCETITTKVIVTYTTVCPVTETHTKPGHTYTTTFTTTSTVQTVVPTTIVITKTAPPVTKSTEKVVYTTLTELCPVTETKVVDGSTVEITWTSTSTVVTKVQQTETIYTTSVATEYETTDVYTTITCPVTTYTTVIEGSTVKVTQTDTITLTNTDVRTITDIVPVTITEVIPVTVNVPVTAQETVTGYSTVIVEATSTVWTSTPLPPATVIIPTSVTLPPVVVVPPPVSSASPPPAGNGTSSVVISTPTSTPPPVATAGAESLVARGGKGVFALLAGLVGAVVLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PB66</accession>
    <name>A0AAN6PB66_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_19488</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854521">
        <property type="protein sequence ID" value="KAK4033593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PB66"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35041:SF3">
        <property type="entry name" value="FORMYLMETHIONINE DEFORMYLASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35041">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="171"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="553"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4033593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="634" mass="69718" checksum="2B2118B5DED08F95" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PBG5</accession>
    <name>A0AAN6PBG5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nitronate monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_40611</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854563">
        <property type="protein sequence ID" value="KAK4032927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PBG5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332:SF36">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G07940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4032927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="353" mass="36731" checksum="ABC3123456C3BAC7" modified="2024-10-02" version="1">MSPPNPITTPLTTLLNIRHPILLAGMARTSTGRLAAAVSNAGGLGVIGGFMYTPSQLRDIIAELKAHLASPDLPFGIDLALPQLGGSARKTNHDYTGGKLAELIDITVESGARLFVSAVGVPPREVIERLHGAGILVMNMVGHPKHAVKALDLGVDMVCAQGGEGGGHTGDVASSVLIPAVVDVARGYKPKMLGGEQTALVVAAGGISNGRGLASALMQGAAGVWVGTRFVASVEAGCSEAHKEEVVSCGFEGTERTLVLSGRPLRMKTNEYIRKWHAQPDKIQELCSKGVVPIEQDLEQGNDIDLPHLMGQVAGAIQKIQPAGEIVDEMVAEAVDMLKLANVYLSGGKGSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PBW9</accession>
    <name>A0AAN6PBW9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_48289</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854441">
        <property type="protein sequence ID" value="KAK4038058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PBW9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42103:SF2">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42103">
        <property type="entry name" value="ALPHA/BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4038058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="478" mass="51642" checksum="AB3B90EA8C5D45A6" modified="2024-10-02" version="1">MAADQGHLPLAMLPKPSLTFTVPSLHDGLPISCRVYHPHSLAAAPDAPSWQKHAAVVAHPYAPLGGCYDDPVVDMMAGTLLRLGFLVATFNFRCGPFSASWRPPLRAHGSAGRTSWTAKAERADYMAVVGFVSHYVHFLDPFTQHTPASSYKSAVQNDGGLEVDGEVTPPIRIRLPTPTPPEPPSGPAPILLLGGYSYGSMITSQLPSVETIVGLFNAPECGTPAAEIRLRAQHLAEMQNTVLASAREAAIDHLRPHSPRKHVGLRVGGDEESRRSHESRRSLSTEFEETIRHGVAELLARTRKGHQRSHSGRSHTPRDSDGVLLEHVSDHLPPVPGRTTFLPAYLLVSPLQGIVTNLATMSLPPLLSMSGKPWTRFPARGSNEAVPSGPSEPGAVPAEAEAKLVQNATLAVYGDRDGFVPVRKLRDWASRLEAMQDSKFRAHEVSSANHFWAQRNVASTLREAVGTFAASLLDDKTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PC83</accession>
    <name>A0AAN6PC83_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Palmitoyltransferase</fullName>
            <ecNumber evidence="10">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">C8A01DRAFT_17678</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="10"/>
    <dbReference type="EMBL" id="MU854436">
        <property type="protein sequence ID" value="KAK4038208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PC83"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF288">
        <property type="entry name" value="PALMITOYLTRANSFERASE SWF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="275"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="11">
        <location>
            <begin position="156"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK4038208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="429" mass="48501" checksum="3CCE2D6B733518F9" modified="2024-10-02" version="1">MGTLATIALVILAISFMVFVTFFGRLPALRRTPIAWLHRLLWVHLPNGLTTLDQRLTGGRVTTSCARFGNYIMYDRHPTVLIFFFILLAGGEYLYLPTAWPQLSPLQKTTGALAIILPYLFLYLAAFSDPGSITPANHIPEMARYPYDFTLFHPGASCATCRLLKPARSKHCSVCRRCVARCDHHCIFINNCVGAGNQHWFILLLLSTGVLTLYGGVLGVRLMTAQIRLRFPAWALLPWRANGGRGMGFTEWLVIWSWGMQDGGRGSGGGVAMGAVTLLALMLSPLVWGLLGYHLWLVYCGTTTNESMKWSDWQVEMGDGFAFKRRLEVGRVKDVRVEPAWTRWPVEPEQVMVRTDDGKLPVGENLPGVGEWEAVWRLKDVENLYDLGFWDNLVDVFVPGFMFRDPHVPVAEDRLRRKKKRRARKIYLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PCR7</accession>
    <name>A0AAN6PCR7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallo-dependent phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_17454</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854428">
        <property type="protein sequence ID" value="KAK4038478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PCR7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07383">
        <property type="entry name" value="MPP_Dcr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32440:SF0">
        <property type="entry name" value="PHOSPHATASE DCR2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32440">
        <property type="entry name" value="PHOSPHATASE DCR2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="1">
        <location>
            <begin position="201"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4038478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="551" mass="60833" checksum="2708243F76A32E0B" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PCT7</accession>
    <name>A0AAN6PCT7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nonselective cation channel</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_19131</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854499">
        <property type="protein sequence ID" value="KAK4034011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PCT7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056337">
        <property type="entry name" value="LHD_YVC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052971">
        <property type="entry name" value="TRP_calcium_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056336">
        <property type="entry name" value="YVC1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859">
        <property type="entry name" value="NONSELECTIVE CATION CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859:SF1">
        <property type="entry name" value="NONSELECTIVE CATION CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23190">
        <property type="entry name" value="LHD_TRPY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23317">
        <property type="entry name" value="YVC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="322"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="381"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="451"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="507"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="564"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="594"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="domain" description="YVC1 N-terminal linker helical" evidence="3">
        <location>
            <begin position="110"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Calcium channel YVC1-like C-terminal transmembrane" evidence="4">
        <location>
            <begin position="328"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="694"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="790"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="791"/>
            <end position="812"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4034011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="832" mass="91657" checksum="7066B25F5064A174" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PD22</accession>
    <name>A0AAN6PD22_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EKC/KEOPS complex subunit BUD32</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">Atypical Serine/threonine protein kinase BUD32</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">EKC/KEOPS complex subunit bud32</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">C8A01DRAFT_49077</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. BUD32 has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit KAE1. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="MU854475">
        <property type="protein sequence ID" value="KAK4034538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PD22"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="1"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK4034538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="270" mass="29863" checksum="49F5D9DB06C3694C" modified="2024-10-02" version="1">MWGVPTSRGFDLPGKLSGEILRIKQGLPPRTGHYEIEGDEIRPLGRCLEYPDMIGDDSEDVSELIAKLPPIDVDPEKHFLKQAKYRRKIENLIRCQGGSVPGKPLSPHVIQLLGRSPDGKLVFEKFSRSASTLGRFSSLATHKSWILQLIDGLDALHSVGIVHRDLRADNLVFSPDGQRLVIIDLESRWGVRAAPEIAANGGLHDSGWSTKSDIYDIGNVVKSMIYANQPITFFVERPVPAPLQAVVDALRSMAEKIRQWDLGTLSKGDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PD30</accession>
    <name>A0AAN6PD30_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Suppressor of anucleate metulae protein B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_18046</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854450">
        <property type="protein sequence ID" value="KAK4035270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PD30"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050869">
        <property type="entry name" value="H3K4_H4K5_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197:SF251">
        <property type="entry name" value="EG:BACR7C10.4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SET" evidence="5">
        <location>
            <begin position="5"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="MYND-type" evidence="6">
        <location>
            <begin position="56"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4035270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="560" mass="61841" checksum="D037B5DFFBEB2BE3" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PDC6</accession>
    <name>A0AAN6PDC6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Inorganic phosphate transporter Pho88</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_17062</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854416">
        <property type="protein sequence ID" value="KAK4038889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PDC6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012098">
        <property type="entry name" value="SND3_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28112">
        <property type="entry name" value="SRP-INDEPENDENT TARGETING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28112:SF1">
        <property type="entry name" value="SRP-INDEPENDENT TARGETING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10032">
        <property type="entry name" value="Pho88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008756">
        <property type="entry name" value="P_tr_PHO88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4038889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="192" mass="20906" checksum="CC607CBCB0E0DBEC" modified="2024-10-02" version="1">MAGLSPQITNLVIILGMMQVAKRIPFEDPNVLNICRGVYIASNLIILSIYIYIKLAIDKKKDMTTLKYVEPAPMGSSEEGKLVTTTVHAYDVGQLKNLMRSQGMGVLMMGVMHIYFKYTNPLLIQSIIPLKGALEANLTKIHVWGQPASGDLKRPFKQAAGFMSGLQSGPAQADKKAVEAAERAGRGGAKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PDE6</accession>
    <name>A0AAN6PDE6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Inositol oxygenase</fullName>
            <ecNumber evidence="4 14">1.13.99.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 14">Myo-inositol oxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">C8A01DRAFT_37181</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 14">
            <text>myo-inositol + O2 = D-glucuronate + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23696"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:58720"/>
            <dbReference type="EC" id="1.13.99.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13 14">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="13 14">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Polyol metabolism; myo-inositol degradation into D-glucuronate; D-glucuronate from myo-inositol: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the myo-inositol oxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.99.1" evidence="4 14"/>
    <dbReference type="EMBL" id="MU854417">
        <property type="protein sequence ID" value="KAK4038853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PDE6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050113">
        <property type="term" value="F:inositol oxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019310">
        <property type="term" value="P:inositol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007828">
        <property type="entry name" value="Inositol_oxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12588:SF0">
        <property type="entry name" value="INOSITOL OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12588">
        <property type="entry name" value="MYOINOSITOL OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05153">
        <property type="entry name" value="MIOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="7 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="12">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="113"/>
            <end position="115"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="170"/>
            <end position="171"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="247"/>
            <end position="248"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR607828-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR607828-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK4038853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="313" mass="36052" checksum="6AF46A3AB310380A" modified="2024-10-02" version="1">MAAAVDARPVHRDGAALEAISDAVDTVNVLRAMAATDGPAFDATSHFDAEKDKSKFRQYDDACDRVKNFYAEQHAKQTVAHNLAARQHFYSPARQRAEMSIWEAMEKLNTLIDDSDPDTELSQIQHLLQSAEAIRRDGKPRWMQLTGLIHDLGKLMLFFDCCQGQWDVVGDTFPVGCRFDERCIYPETFKANPDSRHEFYSTQHGIYQPGCSMNQLLMSWGHDEFLYLVLKDQSTLPREALAMVRFHSFYPWHKEGAYREFMADGDEALLNAVRAFNPYDLYSKSDDVPKVEELKPYYLELIDEFFPKKVIKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PE57</accession>
    <name>A0AAN6PE57_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Isoprenoid synthase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_18874</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854485">
        <property type="protein sequence ID" value="KAK4034307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PE57"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046165">
        <property type="term" value="P:alcohol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001:SF72">
        <property type="entry name" value="THIJ_PFPI FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_3G01210)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19086">
        <property type="entry name" value="Terpene_syn_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="671"/>
            <end position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4034307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="709" mass="78871" checksum="F467DC05D175668C" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PEE4</accession>
    <name>A0AAN6PEE4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_16610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854401">
        <property type="protein sequence ID" value="KAK4039422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PEE4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF4">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4039422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="376" mass="42251" checksum="7E2CC5C2C733DBCF" modified="2024-10-02" version="1">MATPQPPTPTPYILRLPGEIRNQIYSNLILSPVTVPIYQVKKDTDAETTTLASTLIPLLQTCRQIHLEASSLFYSHAQFALPPNASQAPHQIQTNVLFRGFLDRIVPRNAALIRHLVVPFPVDPEALVHAHLKRGGDAVYGDEEGTYGNYRSLVPALAARCPGLETVEFDVRWNNTWVRLLSPHTATVRAMLGRVDGELRAAFPRLKKVGVCLSGPARTWNAAGQFYQRAEEGMAQGEWEWVREALGEGMGWEVTFAEDDLEGTQREGWRSRSGWAASWYPPEPRHAFMVLYGAPNWAIQSEMHDQWTRLDVAKAYVRLGAAWVRSPTKAAQDREEAIEWRRWRRTMLAHAAPVGSSRKGNLKKGVGRFLGSRQRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PEM5</accession>
    <name>A0AAN6PEM5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acyl transferase/acyl hydrolase/lysophospholipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_47864</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854426">
        <property type="protein sequence ID" value="KAK4038535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PEM5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047499">
        <property type="term" value="F:calcium-independent phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019369">
        <property type="term" value="P:arachidonate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046486">
        <property type="term" value="P:glycerolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185:SF1">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3 4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PNPLA" evidence="6">
        <location>
            <begin position="8"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="4">
        <location>
            <begin position="12"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="4">
        <location>
            <begin position="65"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="35"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4038535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="793" mass="86943" checksum="272D3AC87CAC2C3C" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PER2</accession>
    <name>A0AAN6PER2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_36407</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854396">
        <property type="protein sequence ID" value="KAK4039624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PER2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05227">
        <property type="entry name" value="AR_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF579">
        <property type="entry name" value="3-BETA HYDROXYSTEROID DEHYDROGENASE_ISOMERASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_3G02250)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="8"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4039624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="348" mass="37838" checksum="8949BCAEF06B650B" modified="2024-10-02" version="1">MVQPPQYVLVTGATGFIGAHVVDQLLSRGIRVRGATRSLAKGDAMIKARPQHAGKLDFVQIKDFDEMNASERLNIFEEAVKGVDGIIHTASPLTYTTTNNETELLLPAINGVRAILTAAAAPPTPIHRVVLTSSFAAVMDTTRRSPPYFTYTASDWNPLTYADSAAPTTSAVIAYRGSKKFAELAAWDFVQDKKPGFDIATLCPPMTFGPVVHPVASAAKLNESNAMLWKVASGERPLPVARVPFWVDVRDVAKAHVEALVRPEAGGKRFLLAAPERFSYGIAAGIVEEEFPAWAKGRVVREEQVVDDSHGVDGETAARELGLEYRGFRQTVRELVAQVREMEEAGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PF17</accession>
    <name>A0AAN6PF17_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Vegetative incompatibility protein HET-E-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_18085</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854451">
        <property type="protein sequence ID" value="KAK4035226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PF17"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="22"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="411"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4035226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="667" mass="74730" checksum="52791CB9AAB41FFC" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PFV9</accession>
    <name>A0AAN6PFV9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_38274</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854450">
        <property type="protein sequence ID" value="KAK4035252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PFV9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4035252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="190" mass="21402" checksum="82E2C4DCDAD0328F" modified="2024-10-02" version="1">MSHSTRVWQPKALAETIDESFSKPLPYIDRKPGLGVRVATSSTHTLHQTPPMIWLDRNIADYATPAERALAEGRVQEVTIQNCMPALESTHKIECEPDVVRPSALYLLHPVHMALTALHPDVSIHCMSEPYDQNKIRPDVVYKKKGKIFAILEFKVPGSMAEEEFFSASMPWASSRTKIMEHKAKAPEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PFX1</accession>
    <name>A0AAN6PFX1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_15903</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854382">
        <property type="protein sequence ID" value="KAK4040181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PFX1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF31">
        <property type="entry name" value="DUF636 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_2G12650)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="12"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4040181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="436" mass="46898" checksum="04D9033650AA20BF" modified="2024-10-02" version="1">MSSTTNTDTITLKAQCLCRAHSFTTSVPVSALPLKGSSCHCTSCRHVTGALRASDAVWPGPSGDILSAAAAAENGTGTVPLKRYPHSPRVNVLFCGRCGSGLFFEEGWEQGAAAGLGSRPGEAKYLVFTGALSVDVGGEAWRGGLPPLVRGDHIFVGDTVDGGAVGWLRGVNGDGEPARVWLGRRDKSEEVPPGVAWPAVGSLPAYGVDLKAAEGNKGDVPIRCHCRGIDLVLRAGEAQREFEEMQRKGEELPWFVDPVTHKGMGSLDACDSCRIAAGSEVYNWTFALLRHISFAGADPQGFPEDTAHLRAATSAKEGEARDPRFGTIAFYASSPDVQRYFCGRCSATLFYAVDERPDIVDVAVGLLDSPDGARAESAISWSFGGEMSWRRDMIGTWRERMLYAVEKEAEEWRVERGYPKGWRRVAKEQAQKAGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PGD0</accession>
    <name>A0AAN6PGD0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_38009</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854441">
        <property type="protein sequence ID" value="KAK4038050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PGD0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503">
        <property type="entry name" value="MCG48959-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503:SF2">
        <property type="entry name" value="NEGATIVE REGULATOR OF SPORULATION MDS3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="740"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="926"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1029"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="191"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="224"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="750"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="937"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="970"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="1039"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="1057"/>
            <end position="1074"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4038050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1074" mass="113102" checksum="E695CAC5071A102F" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PGF1</accession>
    <name>A0AAN6PGF1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pyranose dehydrogenase 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_46483</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854383">
        <property type="protein sequence ID" value="KAK4040167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PGF1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF115">
        <property type="entry name" value="DEHYDROGENASE XPTC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043050060" evidence="3">
        <location>
            <begin position="26"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="4">
        <location>
            <begin position="303"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4040167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="608" mass="64150" checksum="A9A78E43A6969BE2" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PGN6</accession>
    <name>A0AAN6PGN6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_48137</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854436">
        <property type="protein sequence ID" value="KAK4038200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PGN6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07262">
        <property type="entry name" value="VOC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35006">
        <property type="entry name" value="GLYOXALASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G14830)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35006:SF2">
        <property type="entry name" value="GLYOXALASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G14830)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="227"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="93"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4038200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="367" mass="39624" checksum="ABCECF7A6F925DC8" modified="2024-10-02" version="1">MNPEAFRARIHKFSCKPPGHDAARQRENQRRHRARVKGRVAELEAALLSTHNRLDEALQRIDALTAERPEPDSCAQSESSTLAPESDISPAYTTTQEQDITVTTPTPSHAAIRESQSTSSTTLAEEHANIEDPDDWPLLPAPGAGESTIPCGEAYSIIKDRSAPDFDLSAVNEWLRPGFRRATVPGTGCRCGQGLTEQSAAGFNDLLPFTSSTTLTTTCFTMAQYNPLGHISIGVRDYAVSNAFYTAVLAPLGLKLVYDSEAPSPSTTTTKKAGVRTLGYGRDKEHELLNIFEFSDDAAPPGPGFHLAFNAPTKTAVVEFHAQAMGAGGSDNGLPGVRKHYGAHYFAAFVVDPDGWRLEVVCKDPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PH50</accession>
    <name>A0AAN6PH50_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Beta-ketoacyl-ACP reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_35156</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854369">
        <property type="protein sequence ID" value="KAK4040781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PH50"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G02870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639:SF1">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4040781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="268" mass="28442" checksum="9F1A59DDA01A76BD" modified="2024-10-02" version="1">MVLAVPTASLEGKVALVTGAGRGIGRGVALELARRGASVVVNYVSSAGPAQEVVKEIESYNNGARAIAIQADVSKVPEINRLFEEAKRALGRLDIVMSNSGTESWDKTEEVTEEKYDHVFNLNARAQFFVGQAAFKHLEQDGRLILMTSIAAGLLGVRNHALYNSSKMAVIGMVKAFATDFGVRGITVNGVAPGGIKSDMFTQNAWHYIPGGTPNMPADKIEQLMADHCPLGRCAVPEDVARVVAFLASEDGGWVNGQILTISGGSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PH67</accession>
    <name>A0AAN6PH67_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">lytic cellulose monooxygenase (C4-dehydrogenating)</fullName>
            <ecNumber evidence="15">1.14.99.56</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">C8A01DRAFT_16047</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the polysaccharide monooxygenase AA9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="15"/>
    <dbReference type="EMBL" id="MU854386">
        <property type="protein sequence ID" value="KAK4040003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PH67"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF17">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042860144" description="lytic cellulose monooxygenase (C4-dehydrogenating)" evidence="16">
        <location>
            <begin position="20"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="17">
        <location>
            <begin position="20"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAK4040003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="245" mass="26432" checksum="6E1384386818EA7E" modified="2024-10-02" version="1">MLLNIATLILALAAHRASAHATMFGVSVNGKDAGDFKQFIRSPATNDPVRDLKSPNIVCNTQGGKAAPSFVKAAAGDKLSFRWFHYNPADPADYVLDPSHKGAILTYIAPYTTGNGAGPIWSKLAEEGFEGGKWATIKMIDNKGEVGFTLPKALAAGKYLIRQELLALHMADFAGNDPAHPGRGAESYPSCVQVEVSDKGAGDAIPDQDFDFNTGYKYEDKGLHFNIYIPFDKYTPPGPRPWTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PHI8</accession>
    <name>A0AAN6PHI8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7708 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_35048</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854366">
        <property type="protein sequence ID" value="KAK4040991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PHI8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056125">
        <property type="entry name" value="DUF7708"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24809">
        <property type="entry name" value="DUF7708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7708" evidence="1">
        <location>
            <begin position="129"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4040991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="783" mass="87583" checksum="85CDA2743CA4EE6A" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PHJ2</accession>
    <name>A0AAN6PHJ2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_15081</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854363">
        <property type="protein sequence ID" value="KAK4041109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PHJ2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4041109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="175" mass="19689" checksum="72C2A27F2493E2A4" modified="2024-10-02" version="1">MLWRSLTTNLLQLALDENSRYTVEYVIQLITQKFGRWLNPLEGPAKKHLHADLRNLAERVIKLDWEMHRSSTLYDFHFKDQATGKEHGFLYKKTKPPVMQPHSVSSDVRYQEGYPVDLVVVPLLIARGDPLMPPGDWGSGHIVNPLEVAIDMFPEEEADMPEPGAGGDAAGPSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PHV2</accession>
    <name>A0AAN6PHV2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribonuclease P/MRP protein subunit POP5</fullName>
            <ecNumber evidence="4">3.1.26.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">C8A01DRAFT_45598</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of RNase MRP, which cleaves pre-rRNA sequences.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.</text>
            <dbReference type="EC" id="3.1.26.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic/archaeal RNase P protein component 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.5" evidence="4"/>
    <dbReference type="EMBL" id="MU854362">
        <property type="protein sequence ID" value="KAK4041156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PHV2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030681">
        <property type="term" value="C:multimeric ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033204">
        <property type="term" value="F:ribonuclease P RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3250:FF:000004">
        <property type="entry name" value="Ribonuclease P/MRP protein subunit POP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3250">
        <property type="entry name" value="Ribonuclease P, Pop5 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002759">
        <property type="entry name" value="Pop5/Rpp14/Rnp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038085">
        <property type="entry name" value="Rnp2-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15441">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15441:SF2">
        <property type="entry name" value="RIBONUCLEASE P_MRP PROTEIN SUBUNIT POP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01900">
        <property type="entry name" value="RNase_P_Rpp14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160350">
        <property type="entry name" value="Rnp2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="164"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00055200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK4041156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="196" mass="21065" checksum="92BF51588CC746CC" modified="2024-10-02" version="1">MVRLKDRYLLVNIIYTDVPPGQAKGGAVPDLLLYNQPTTSELRPQLLLKGIRSEVAALFGDCGAGAIDRSLQVKYLSPATSTFILRISRAHYRLVWAALAFMSRVPVRDGRPCVFRVVRVSGTVRKVEEEAVRRARLLVLAAKDEMAGNRGSSAADALGALLRSDSSSQARSVAVPGGQVDSEPEAESQGLSSDDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PHV9</accession>
    <name>A0AAN6PHV9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_34686</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854360">
        <property type="protein sequence ID" value="KAK4041274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PHV9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="575"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4041274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="660" mass="73433" checksum="AEDFD48A8277BD5A" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PI07</accession>
    <name>A0AAN6PI07_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_34947</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854365">
        <property type="protein sequence ID" value="KAK4041007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PI07"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="462"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="280"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4041007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="492" mass="54087" checksum="457D9E54C5D6A7DA" modified="2024-10-02" version="1">MCQPPTNDVVREMLGLVVPEDVTVKKVQLAPSVRPPRTYEVLLSDGRTLHLVLPPISMWRPLRAEQGMLTSEAITVRWLSDTLAREDSATAEQNAPSSSSKPDLATSLLPLLPTLLRHGQETHLANSSFAVYDPVSGAPLSLFSPEPSLSTQREIDRQLGALFRNLAAITSPTGRFGPLAAVVDTKTPQPAAGPSQGKAPKLPKVLIEGGLSVTGGAGTWSVAFHSMLEGVLRDGEDMAVLISYPTIRRHFRRLGYLLDEVTTGRLVVVEGAGRGNVLVEGTEVGEQQQQEQQQRRDGEEQEEDVEDPEGGEEAVKDEERAGKEADSAEKGESKTTTIHQKDDTQPQQTPKLTGLRDWSSAVFGDPLLATIFSDPHQQPPSAAFLEGFNDEKLDPDPRHTHLPYPLNRAIIEGVDTAWIRLLFYQAYHAVARIVSEFYRPRQDSSARELEARRKLNEVLAKLAEVPDDSKKKHQRPSGEMSPAKRLRGAEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PIB0</accession>
    <name>A0AAN6PIB0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_14777</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="MU854356">
        <property type="protein sequence ID" value="KAK4041478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PIB0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF39">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="4">
        <location>
            <begin position="187"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4041478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="304" mass="34524" checksum="B630E12B4FC6F8EC" modified="2024-10-02" version="1">MPALAPNTSDVVDAMSDADLAAHIAQLRKEKGGNSRVIEVSEGHFTKRYEEQDVENAKCAMMKAEALGVAVPSVKQVVRRGEVFEIVQARIHDHDLMTIWSDLGLLSTVRLAFQMRGMLRRMETATSPTAGSLGTGLCRSFWIENDIYGIPRHASPATISSIVNFWHNLVSFRQESKKTPEEHRESCLLPRTPEKGFVFVHHDLAPRNIMLENITGKLWLVDWDYAGFYPAYFEHAAMHNFIPPPEWSWFSRWRWRLFAWIATGLYSGARAMLVEVRRKTHRFPASRRFNVKAGASPSVKAADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PIC9</accession>
    <name>A0AAN6PIC9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RAVE subunit 2/Rogdi</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_45358</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854356">
        <property type="protein sequence ID" value="KAK4041508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PIC9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043291">
        <property type="term" value="C:RAVE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028241">
        <property type="entry name" value="RAVE2/Rogdi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13618">
        <property type="entry name" value="LEUCINE ZIPPER CONTAINING TRANSCRIPTION FACTOR LZF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13618:SF1">
        <property type="entry name" value="PROTEIN ROGDI HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10259">
        <property type="entry name" value="Rogdi_lz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="306"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4041508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="377" mass="40673" checksum="7DEC9AC9AC024731" modified="2024-10-02" version="1">MSVEIWPHVAPDQLKAAIETAEKRELDWLIDELRETLTNLKHGLEDCYALLAPIDPGSTLVLSTPRNEVVKGHVTRVGTRIVKGTIHLRLRTLPQQTLTINPDHPIHLTSLTTLHSLLTHSIDLLALTLSYSYPSATPTAPLPTDLPPPHFLSAQLRLLAQSLAEASTHLKGTPQTAPDPSWTTLSASPSHFTPPLPQPHTNSSHPSLSFHLSIQDSSLVLWLRALEPADAPLNFGTKLALAIGTTRRLEHDESEKVFGYCCNGNVNDAEHTHSTPPAALPQEHTTTATSHTPPGNQPVPLSGTRKPNNSHSNNSSSTTKHPAVDVFVREKVRVESADPSLLSLSAKLTALGHTLALARRNLAAVMGEEVGGEGGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PIG8</accession>
    <name>A0AAN6PIG8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Amidoligase enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_46854</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854393">
        <property type="protein sequence ID" value="KAK4039751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PIG8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022025">
        <property type="entry name" value="Amidoligase_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36847">
        <property type="entry name" value="AMIDOLIGASE ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36847:SF1">
        <property type="entry name" value="AMIDOLIGASE ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12224">
        <property type="entry name" value="Amidoligase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4039751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="516" mass="57532" checksum="F42DF34FA4F7F6F4" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PJ26</accession>
    <name>A0AAN6PJ26_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CST complex subunit Ten1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_45129</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854351">
        <property type="protein sequence ID" value="KAK4041801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PJ26"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990879">
        <property type="term" value="C:CST complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043047">
        <property type="term" value="F:single-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016233">
        <property type="term" value="P:telomere capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024222">
        <property type="entry name" value="Ten1_fungal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12658">
        <property type="entry name" value="Ten1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4041801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="140" mass="14940" checksum="DDC9F31BCFA1F1EE" modified="2024-10-02" version="1">MSYGPRPSQLCLLSALPKKQVGDKVRFLGCVTSYSPVSGVLALEHRLPEETRSVVALVDVNVVLESLGSEQTRVGEWVNVIGYVTDAAPLADGKESSRGSPTVHTQAILLWSAGPFDIRKYEASVMALARANSAGCRVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PJD3</accession>
    <name>A0AAN6PJD3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_15886</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854382">
        <property type="protein sequence ID" value="KAK4040216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PJD3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF20">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="9"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="522"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="690"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="527"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="582"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4040216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="716" mass="78367" checksum="60A7C5A0B2FD80BB" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PJH3</accession>
    <name>A0AAN6PJH3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="15">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">C8A01DRAFT_44915</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits. Binds 90S pre-ribosomal particles and dissociates from pre-60S ribosomal particles after processing of 27SB pre-rRNA. Required for the normal formation of 18S rRNA through the processing of pre-rRNAs at sites A0, A1 and A2, and the normal formation of 25S and 5.8S rRNAs through the processing of pre-rRNAs at sites C1 and C2.</text>
    </comment>
    <comment type="function">
        <text evidence="15">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of pre-60S ribosomal complexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="15">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="15"/>
    <dbReference type="EMBL" id="MU854347">
        <property type="protein sequence ID" value="KAK4042026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP001303115">
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    </dbReference>
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        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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    </dbReference>
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        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="DEADc_DDX55"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="CTT_SPB4"/>
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        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
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        <property type="entry name" value="Helicase_ATP-bd"/>
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        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23681">
        <property type="entry name" value="CTT_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="17">
        <location>
            <begin position="45"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="18">
        <location>
            <begin position="283"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="545"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="582"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="599"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="632"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037566"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00038002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00038757"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAK4042026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="641" mass="71001" checksum="E1EFBF2283E06403" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PJT1</accession>
    <name>A0AAN6PJT1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribonuclease H-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_35583</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854377">
        <property type="protein sequence ID" value="KAK4040441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PJT1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02846">
        <property type="entry name" value="PAZ_argonaute_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Piwi_ago-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014811">
        <property type="entry name" value="ArgoL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
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        <property type="entry name" value="Piwi_ago-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
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        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ArgoL1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DUF1785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="447"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4040441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="797" mass="88715" checksum="27FF12BF600ED295" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PJY6</accession>
    <name>A0AAN6PJY6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ubiquitin-conjugating enzyme/RWD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_14037</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854342">
        <property type="protein sequence ID" value="KAK4042378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PJY6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23797">
        <property type="entry name" value="UBCc_UBE2H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000061">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="6">
        <location>
            <begin position="3"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="152"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="158"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4042378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="190" mass="21553" checksum="B94BAAAE0CC065B7" modified="2024-10-02" version="1">MASPRRRIETDVSRPCRLMSDYEVTLVNDNSMQEFFVKFKGPSETPFEGGVWKVHVELPEQYPYKSPSIGFVNRIFHPNIDELSGSVCLDVINQTWSPMYDMINIFEVFLPQLLRYPNPSDPLNGEAAALLLRDPKNYEVKVKDYVQRYATKNAADEAGAESEDDDDLSSVGSYNDDDEEAQPAGQMDDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PK32</accession>
    <name>A0AAN6PK32_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_14174</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854345">
        <property type="protein sequence ID" value="KAK4042147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PK32"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4042147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="448" mass="49886" checksum="63DC974E788F386C" modified="2024-10-02" version="1">MARLNLTDLPPELLTEICSFLCCHCLELQSTVFSPVTAQSDPDHGQAQPRRADLLSLARVCRVLRGVAELFLYHSFHTSRTSDLYFFVRTLLDRPDLRLRVLDVDVGPSLVHAGDPLLARGRPEDAAELVESAEHAALISLLLQLVPNVESSHLHLPLFKAFPDLGRLESTHSPMLSLKRLAFTDLKRGFILDGTSPILRLAPNLEILRCHNCDDVSKVFLATLGRKMPSNPRPLQALAKLTLRNTSLTAASLLHLLEAVGPRLSKVDIRRSIGRQSRGYYQSLGEPKIEFNEVVTALQPWSHSLQELSFSMHEIDMILPRSPDHFAGVHLLREFRELRSLRTPADCLDFHGHLGRREDALAATLPPSIRELRLLGYSSIVPGLQGLARAFGAGQFAELQRIEVDHPAFEAGQLQLEAAREVREVAASFWPAGVDFVIHPKLGDFDSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PK67</accession>
    <name>A0AAN6PK67_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">YAP1-binding protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_46626</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854387">
        <property type="protein sequence ID" value="KAK4039970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PK67"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013877">
        <property type="entry name" value="YAP-bd/ALF4/Glomulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040347">
        <property type="entry name" value="YBP1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28020">
        <property type="entry name" value="YAP1-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28020:SF1">
        <property type="entry name" value="YAP1-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08568">
        <property type="entry name" value="Kinetochor_Ybp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4039970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="645" mass="71370" checksum="B7EABEAD0EA4AE2E" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PKT6</accession>
    <name>A0AAN6PKT6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">C8A01DRAFT_34070</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854350">
        <property type="protein sequence ID" value="KAK4041820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PKT6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00747">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="9" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043008315" description="CFEM domain-containing protein" evidence="12">
        <location>
            <begin position="27"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="33"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="235"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="13">
        <location>
            <begin position="61"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="168"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK4041820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="261" mass="25598" checksum="E13C2A89AF74DAF8" modified="2024-10-02" version="1">MQMKIPAHLAAIAFVLFVGLVSFVETSPSLAALVAAVVALWAALPSVSPLALATTFFALVGPVSPVAAAPTPGAAALAVAAVVDGLPSCAKPVMNSMVFRAASFGCDMADGTPDVACLCRSRPFKRLAKGGVHAECPDEADLGASREWAIARCTAALSAAGQGVSRVPAAGTNGTASPAPSSPSPSLPAGTSLATPADAAVRQPAAVAAAAAPTATVIAAAVFDIDDDEDETSGAVVVVRPAGTAALLLAAVVLAPAFQHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PL41</accession>
    <name>A0AAN6PL41_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">NADP-dependent malic enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_13342</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the malic enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854332">
        <property type="protein sequence ID" value="KAK4043038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PL41"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004471">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05312">
        <property type="entry name" value="NAD_bind_1_malic_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10380:FF:000007">
        <property type="entry name" value="Malic enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000182">
        <property type="entry name" value="NAD-dependent malic enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10380">
        <property type="entry name" value="Malic enzyme, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012301">
        <property type="entry name" value="Malic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037062">
        <property type="entry name" value="Malic_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001891">
        <property type="entry name" value="Malic_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010052">
        <property type="entry name" value="PRK13529.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406">
        <property type="entry name" value="MALIC ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406:SF32">
        <property type="entry name" value="NADP-DEPENDENT MALIC ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00390">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00072">
        <property type="entry name" value="MALOXRDTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01274">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00919">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Malic enzyme N-terminal" evidence="8">
        <location>
            <begin position="291"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Malic enzyme NAD-binding" evidence="7">
        <location>
            <begin position="481"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="54"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="133"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="54"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="135"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4043038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="782" mass="86468" checksum="77066AFB1E20D759" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PL47</accession>
    <name>A0AAN6PL47_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Complex proteins associated with Set1p component shg1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_13530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854334">
        <property type="protein sequence ID" value="KAK4042926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PL47"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055264">
        <property type="entry name" value="BOD1/SHG1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28034:SF1">
        <property type="entry name" value="NUCLEOMORPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28034">
        <property type="entry name" value="SET1 COMPLEX COMPONENT SHG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05205">
        <property type="entry name" value="COMPASS-Shg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BOD1/SHG1" evidence="2">
        <location>
            <begin position="45"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4042926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="221" mass="24817" checksum="EE2F0279114CA204" modified="2024-10-02" version="1" fragment="single">MSAAVESAASAAPGEPDAVALPVPKKFKASDLPLPSATRTAIEGLAHSFKKKGGYDAIRKQVWEKFEASDYEAQVTKAILEVAEREVERNPTQLLTLERGKAAALIDGALDRGGVYQKAEEVIGALIDSRAIEAHIRQLRRAEIGDVAAEEERMRGSKTDEEYAAETAARRAERERVREELRAVEEKKRQLEREIKAREEAKRREAERAAREERRKKEREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PLC0</accession>
    <name>A0AAN6PLC0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 13">Mitogen-activated protein kinase</fullName>
            <ecNumber evidence="2 13">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">C8A01DRAFT_34953</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="13">Activated by threonine and tyrosine phosphorylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="2 13"/>
    <dbReference type="EMBL" id="MU854365">
        <property type="protein sequence ID" value="KAK4041011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PLC0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0075018">
        <property type="term" value="P:positive regulation of appressorium formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07849">
        <property type="entry name" value="STKc_ERK1_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000040">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000073">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 13 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="21"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK4041011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="353" mass="40969" checksum="D6DC040BADCCEDF8" modified="2024-10-02" version="1">MSNAQNRGGARKISFNVSEQYDIQDVVGEGAYGVVCSAVHKPSGQKVAIKKITPFDHSMFCLRTLREMKLLRYFNHENIISILDIQKPRSYETFNEVYLIQELMETDMHRVIRTQELSDDHCQYFIYQTLRALKAMHSANVLHRDLKPSNLLLNANCDLKVCDFGLARSAASQEDNSGFMTEYVATRWYRAPEIMLTFKEYTKAIDVWSVGCILAEMLSGKPLFPGKDYHHQLTLILDVLGTPTMEDYYGIKSRRAREYIRSLPFKKKVPFRTLFPNTSDLALDLLEKLLAFNPVKRITVEEALKHPYLEPYHDPDDEPTAPPIPEEFFDFDKHKDNLSKEQLKQLIYQEIMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PLI3</accession>
    <name>A0AAN6PLI3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nitrogen permease regulator 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_44776</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NPR2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854344">
        <property type="protein sequence ID" value="KAK4042255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PLI3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990130">
        <property type="term" value="C:GATOR1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009348">
        <property type="entry name" value="NPR2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12991:SF10">
        <property type="entry name" value="GATOR COMPLEX PROTEIN NPRL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12991">
        <property type="entry name" value="NITROGEN PERMEASE REGULATOR 2/TUMOR SUPPRESSOR CANDIDATE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06218">
        <property type="entry name" value="NPR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="291"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="291"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4042255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="473" mass="51980" checksum="3211ADD930290633" modified="2024-10-02" version="1">MIQGIFYARFFPQEGTKIVSQSPPGCIVPVPGAMTTKPPLFDFNVLQEYIIPRQAFCNRYITVAGPEGKYFVLGFPVSIPSSRYERNEFIFNFGLVVENDVDQVPYERVVRRLAVTFAEMEKQSGFLSQDADAASGRRPIGSLLEIIKEDLNNYGECMTPVDDANTINMKLFPHHPTPPEVKGWHVPVAKMKFADVVDPTWDLTLQRVVTHIDGVSDVRRIAFLADVSLELTQLALRHLLYYDTILLLDMFFFGACYAPRPGIHDFIANVGGMVDECANYVCVGAATSASSNSSSGQQQPSQAAAGSVGAAGGGAEREGSSTGQGGDDNPTENSHDDSTTTTTTHGHRVSNYMLIKLMTTFCVGKTVAEWLKGHMDGGFDVLRFVDVRRLVQFGVIKGCLYRVHKYVVSKQYLAALATGQARPVAGGDPLQRYTDGCRTFDQIITEQNLTDAEIMDKLKSFPAPAGDLTVLYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PLL4</accession>
    <name>A0AAN6PLL4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_32628</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854329">
        <property type="protein sequence ID" value="KAK4043308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PLL4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042990991" evidence="1">
        <location>
            <begin position="18"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4043308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="102" mass="10696" checksum="695E83876E1AC20B" modified="2024-10-02" version="1">MKLNVAVLSFLVGHATAAIGSLCKANGITGTCQSNSWCDNNDGQRPVRGACPNDPSNVMCCIYPLCNNGICMSTSDSFCGQLDGGFVSNRCPGPTSYKCCVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PLU6</accession>
    <name>A0AAN6PLU6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_34543</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854357">
        <property type="protein sequence ID" value="KAK4041459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PLU6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF90">
        <property type="entry name" value="CENTROMERE DNA-BINDING PROTEIN COMPLEX CBF3 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="4">
        <location>
            <begin position="127"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="535"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="603"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="614"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4041459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="714" mass="77905" checksum="39B1DEF9980AB874" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PLY8</accession>
    <name>A0AAN6PLY8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6594 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_15236</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854366">
        <property type="protein sequence ID" value="KAK4040930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PLY8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046529">
        <property type="entry name" value="DUF6594"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34502:SF5">
        <property type="entry name" value="DUF6594 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34502">
        <property type="entry name" value="DUF6594 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20237">
        <property type="entry name" value="DUF6594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="193"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6594" evidence="3">
        <location>
            <begin position="2"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="15"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4040930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="276" mass="31320" checksum="7F5EC95B604FDFC5" modified="2024-10-02" version="1">MAAFRRFGALSAEDLLYRQAELVELERNLREYQEEDKKSGHEDRERYGFNWDTLRRSADDDAADGNDGSQWETVLEIREKLKEYHEAVLRHRRMLEVPQPLASQVKALDHWMQRPSMGNVYLTGSDSKIWREPNLEDMITLAPKLPEDNFVTEFTIKLIQWYNKLLGRHIHKEETHEFLQNTIRYRDNETFRILKTLSTLVASLLPIAGIAVLYTIQSMPGRLGAVAGFTAVFSFLLSTITSASTKDVFSATATFAAVLVVFVGTTESSAGGTVGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PMA9</accession>
    <name>A0AAN6PMA9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA sliding clamp PCNA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">C8A01DRAFT_43437</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Involved in DNA repair.</text>
    </comment>
    <comment type="function">
        <text evidence="12">This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processivity during elongation of the leading strand.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the PCNA family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pyridoxine kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854325">
        <property type="protein sequence ID" value="KAK4043683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PMA9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043626">
        <property type="term" value="C:PCNA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030337">
        <property type="term" value="F:DNA polymerase processivity factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008478">
        <property type="term" value="F:pyridoxal kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006273">
        <property type="term" value="P:lagging strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009443">
        <property type="term" value="P:pyridoxal 5'-phosphate salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006275">
        <property type="term" value="P:regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00577">
        <property type="entry name" value="PCNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01173">
        <property type="entry name" value="pyridoxal_pyridoxamine_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.150.10:FF:000006">
        <property type="entry name" value="Proliferating cell nuclear antigen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.150.10:FF:000008">
        <property type="entry name" value="Proliferating cell nuclear antigen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.150.10">
        <property type="entry name" value="DNA Polymerase III, subunit A, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00317">
        <property type="entry name" value="DNApol_clamp_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046938">
        <property type="entry name" value="DNA_clamp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013749">
        <property type="entry name" value="PM/HMP-P_kinase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000730">
        <property type="entry name" value="Pr_cel_nuc_antig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022649">
        <property type="entry name" value="Pr_cel_nuc_antig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022659">
        <property type="entry name" value="Pr_cel_nuc_antig_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022648">
        <property type="entry name" value="Pr_cel_nuc_antig_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004625">
        <property type="entry name" value="PyrdxlKinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00590">
        <property type="entry name" value="pcna"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00687">
        <property type="entry name" value="pyridox_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11352">
        <property type="entry name" value="PROLIFERATING CELL NUCLEAR ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11352:SF0">
        <property type="entry name" value="PROLIFERATING CELL NUCLEAR ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02747">
        <property type="entry name" value="PCNA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00705">
        <property type="entry name" value="PCNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08543">
        <property type="entry name" value="Phos_pyr_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00339">
        <property type="entry name" value="PCNACYCLIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55979">
        <property type="entry name" value="DNA clamp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01251">
        <property type="entry name" value="PCNA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00293">
        <property type="entry name" value="PCNA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Proliferating cell nuclear antigen PCNA N-terminal" evidence="14">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Proliferating cell nuclear antigen PCNA C-terminal" evidence="15">
        <location>
            <begin position="127"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridoxamine kinase/Phosphomethylpyrimidine kinase" evidence="16">
        <location>
            <begin position="352"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00054163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF08543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAK4043683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="602" mass="66099" checksum="B765DDE717E7F2C6" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PMB5</accession>
    <name>A0AAN6PMB5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cysteine synthase 2</fullName>
            <ecNumber evidence="4">2.5.1.47</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Cysteine synthase-like protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">O-acetylserine (thiol)-lyase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">O-acetylserine sulfhydrylase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">C8A01DRAFT_32227</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate</text>
            <dbReference type="Rhea" id="RHEA:14829"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:58340"/>
            <dbReference type="EC" id="2.5.1.47"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.47" evidence="4"/>
    <dbReference type="EMBL" id="MU854325">
        <property type="protein sequence ID" value="KAK4043698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PMB5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01561">
        <property type="entry name" value="CBS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000096">
        <property type="entry name" value="Related to cysteine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050214">
        <property type="entry name" value="Cys_Synth/Cystath_Beta-Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314">
        <property type="entry name" value="CYSTATHIONINE BETA-SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="17">
        <location>
            <begin position="83"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00072090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00078263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00078545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00079149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAK4043698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="442" mass="47500" checksum="4C02483294C25C40" modified="2024-10-02" version="1">MSLSDHPRVYGTAALTVAFIAGIFVTLGFKDLYPELEARYERRKKRSRRGSLFFGPVSLEDREESSLSVTNYDRGNGIADGIEGTIGNTPLIQIRSLSEATGCIILAKAEFLNGAGGSPKDRVALNMIQVAEEQGLLSPGRGDTIYEGTVGSTGISLAVLARARGYKAHICMPDDMAVEKSDLLHHLGATIERVPVAPITDPGHFVNLARSRAREHTAAADTPSRGFFADQFESLANYSAHMKTTGPEIYAQTGGGQLDAFVAGAGTGGTIAGVAKHLKEERGLSALRVVLADPQGSGLYNKIRHGVMYSATEREGTRRRRQVDTMVEGIGINRVTENFEAGRGLVDDAVKVTDEQACRMARWLVERDGIFVGSSSAVNCVAAVVTALKMPPGSRVVTILCDSGTRHLSKFWKHIAAMGLEDETQEQDGDLLAVLGLQDLQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PMD2</accession>
    <name>A0AAN6PMD2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_33218</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854337">
        <property type="protein sequence ID" value="KAK4042690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42105">
        <property type="entry name" value="DIM2-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42105:SF1">
        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="492"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="802"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="923"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1024"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1061"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1272"/>
            <end position="1305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1374"/>
            <end position="1541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1559"/>
            <end position="1629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1654"/>
            <end position="1859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="155"/>
            <end position="168"/>
        </location>
    </feature>
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        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
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        <location>
            <begin position="261"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="325"/>
            <end position="343"/>
        </location>
    </feature>
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        <location>
            <begin position="352"/>
            <end position="363"/>
        </location>
    </feature>
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        <location>
            <begin position="408"/>
            <end position="421"/>
        </location>
    </feature>
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        <location>
            <begin position="431"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="557"/>
            <end position="570"/>
        </location>
    </feature>
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        <location>
            <begin position="573"/>
            <end position="587"/>
        </location>
    </feature>
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        <location>
            <begin position="588"/>
            <end position="597"/>
        </location>
    </feature>
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        <location>
            <begin position="637"/>
            <end position="647"/>
        </location>
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        <location>
            <begin position="648"/>
            <end position="662"/>
        </location>
    </feature>
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        <location>
            <begin position="699"/>
            <end position="710"/>
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        <location>
            <begin position="741"/>
            <end position="750"/>
        </location>
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            <begin position="802"/>
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            <begin position="993"/>
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        <location>
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            <end position="1407"/>
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        <location>
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        <location>
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            <end position="1470"/>
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    </feature>
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        <location>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1511"/>
            <end position="1524"/>
        </location>
    </feature>
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        <location>
            <begin position="1582"/>
            <end position="1596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1599"/>
            <end position="1609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1654"/>
            <end position="1668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1684"/>
            <end position="1701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1711"/>
            <end position="1737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1773"/>
            <end position="1805"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4042690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1859" mass="200707" checksum="CBBEF148C8D3B462" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PMR6</accession>
    <name>A0AAN6PMR6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Deoxyuridine 5'-triphosphate nucleotidohydrolase</fullName>
            <shortName evidence="10">dUTPase</shortName>
            <ecNumber evidence="10">3.6.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">dUTP pyrophosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">C8A01DRAFT_12825</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in nucleotide metabolism via production of dUMP, the immediate precursor of thymidine nucleotides, and decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.</text>
    </comment>
    <comment type="function">
        <text evidence="2">This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>dUTP + H2O = dUMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10248"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61555"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="3.6.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 10">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the dUTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.23" evidence="10"/>
    <dbReference type="EMBL" id="MU854325">
        <property type="protein sequence ID" value="KAK4043682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PMR6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004170">
        <property type="term" value="F:dUTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006226">
        <property type="term" value="P:dUMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046081">
        <property type="term" value="P:dUTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07557">
        <property type="entry name" value="trimeric_dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.40.10:FF:000004">
        <property type="entry name" value="Deoxyuridine triphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008181">
        <property type="entry name" value="dUTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029054">
        <property type="entry name" value="dUTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033704">
        <property type="entry name" value="dUTPase_trimeric"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00576">
        <property type="entry name" value="dut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001862">
        <property type="entry name" value="PRK00601.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241">
        <property type="entry name" value="DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241:SF0">
        <property type="entry name" value="DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00692">
        <property type="entry name" value="dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="dUTPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="dUTPase-like" evidence="12">
        <location>
            <begin position="61"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="26"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK4043682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="191" mass="20181" checksum="9AA7AEACCC8C73D4" modified="2024-10-02" version="1">MTAETTSTPNEPIAPTSPPAKRIKTDTSANTASETMASNGTATQQQELQPPPLLIKKLSDKARIPTRGSAFAAGYDLCAARLTTIPARGKALVDTDISMSLPAGTYGRIAPRSGLAAKHFIDTGAGVIDADYRGHVKVLLFNHADADFEVQEGDRIAQLIVERIYTPEVVEVQELEESVRGAGGFGSTGTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PMY1</accession>
    <name>A0AAN6PMY1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Fungal-specific transcription factor-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_44181</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854335">
        <property type="protein sequence ID" value="KAK4042823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PMY1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="5">
        <location>
            <begin position="359"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="769"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="770"/>
            <end position="781"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4042823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="795" mass="87987" checksum="13DE5E5A3B97BB1B" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PND8</accession>
    <name>A0AAN6PND8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DUF676 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">C8A01DRAFT_12348</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the putative lipase ROG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854320">
        <property type="protein sequence ID" value="KAK4044244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PND8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007751">
        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052374">
        <property type="entry name" value="SERAC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182:SF2">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="653"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1074"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1116"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="domain" description="DUF676" evidence="12">
        <location>
            <begin position="170"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="30"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="448"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="927"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1171"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="476"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="520"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="927"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="952"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1171"/>
            <end position="1185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF05057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK4044244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1232" mass="138149" checksum="F76D6B90699767AA" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PPU7</accession>
    <name>A0AAN6PPU7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NCT transcriptional regulatory complex subunit B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Negative cofactor 2 B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_12726</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Part of the NCT transcriptional regulatory complex that acts as a key regulator of ergosterol biosynthesis and the azole exporter cdr1B. The NCT complex binds the promoters of genes linked to azole susceptibility, and especially represses the expression of cdr1B transporter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Forms the NCT transcriptional regulatory complex with nctA and mot1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854324">
        <property type="protein sequence ID" value="KAK4043798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PPU7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017054">
        <property type="term" value="C:negative cofactor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22905">
        <property type="entry name" value="HFD_Dr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000019">
        <property type="entry name" value="Negative cofactor 2 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042225">
        <property type="entry name" value="Ncb2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46138">
        <property type="entry name" value="PROTEIN DR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46138:SF1">
        <property type="entry name" value="PROTEIN DR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="7">
        <location>
            <begin position="13"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00053814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00065193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00072420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00079659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4043798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="138" mass="15066" checksum="9526D6C3922BDE59" modified="2024-10-02" version="1">MSDHEFGGNDDLSLPKATVQKIVGEILSGSSGIAFSKEARDVLIECCVEFITLISSEANEISEKEAKKTIACDHIIKALDQLGFPDYVPAVLEAAAEHKEVQKGREKKANKLEQSGLSLEELERLQQEQFAAAAARHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PQG0</accession>
    <name>A0AAN6PQG0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">4a-hydroxytetrahydrobiopterin dehydratase</fullName>
            <ecNumber evidence="3">4.2.1.96</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">4-alpha-hydroxy-tetrahydropterin dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_32520</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin = (6R)-L-erythro-6,7-dihydrobiopterin + H2O</text>
            <dbReference type="Rhea" id="RHEA:11920"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15642"/>
            <dbReference type="ChEBI" id="CHEBI:43120"/>
            <dbReference type="EC" id="4.2.1.96"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pterin-4-alpha-carbinolamine dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.96" evidence="3"/>
    <dbReference type="EMBL" id="MU854328">
        <property type="protein sequence ID" value="KAK4043394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PQG0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008124">
        <property type="term" value="F:4-alpha-hydroxytetrahydrobiopterin dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006729">
        <property type="term" value="P:tetrahydrobiopterin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00488">
        <property type="entry name" value="PCD_DCoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.20">
        <property type="entry name" value="Transcriptional coactivator/pterin dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036428">
        <property type="entry name" value="PCD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001533">
        <property type="entry name" value="Pterin_deHydtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12599">
        <property type="entry name" value="PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12599:SF0">
        <property type="entry name" value="PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01329">
        <property type="entry name" value="Pterin_4a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55248">
        <property type="entry name" value="PCD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="120"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="127"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4043394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="170" mass="18626" checksum="DF3E3D871C74CE1D" modified="2024-10-02" version="1">MSSSQQPRFAADSDPDALETFLLPLVTANGGRWTLTMEGEALEREFKFKTFAKTWDFMTAVSLQCKLKNHHPEWSNVFNTTFIRWTTHHPRGLSSKDIELATLCDKLAADFGEVAVAAVEQKKPQEQGEQPQPQQQQQQQGGEGACSLSGLANRAVGSAGDCCVPKGATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PQV9</accession>
    <name>A0AAN6PQV9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_42742</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854318">
        <property type="protein sequence ID" value="KAK4044565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PQV9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="244"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4044565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="311" mass="34057" checksum="D3C3A50E239EA040" modified="2024-10-02" version="1">MLLPSALPCDSSQTPPLTRLQAALFASPPASPPQVSPQTAIGNIFSTCRSLQTLLTNPATSSSVAQEPITPPTSSHAQLPTPPLAHAPPPLKLRLRSRKMETTTATGDHGPARKRIVKRTASVAQQAPRGPNKRRRAVDDEMGRYNEDESDMEQHHEQLLDNPFDSQDRANDAQPESAPHTPKRSRIAPEVIPLGLERGDYHSLHSSFSSSFSSNDNLPTAASESGTQQQQGSDVVVEADGEAWSTEEDRILVELVLEKLKLTKSDWQDCARSLGKDRGSVGRRWKSLMINGDVGLKRGSHRRGRIHGTWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PR72</accession>
    <name>A0AAN6PR72_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribonuclease H-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_11997</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854317">
        <property type="protein sequence ID" value="KAK4044745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PR72"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43040">
        <property type="entry name" value="RIBONUCLEASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43040:SF1">
        <property type="entry name" value="RIBONUCLEASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3'-5' exonuclease" evidence="1">
        <location>
            <begin position="10"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4044745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="252" mass="27957" checksum="E6F04C776110ECC5" modified="2024-10-02" version="1">MATPASSGLIDTATAMSALVDVLDGQPTSPPSLYMDVEGVNLSRHGTISILQVHVLPLRQTYLVDVHTLGDTAFLAASLTTGRTFKDILESTTVPKVFFDVRNDSDALYGNFQIRLAGIQDLQLMELATRSFPRRFVSGLAKCIEQAGLLSVVERRTWAATKERGRKLFAPELGGSYRVFNERPLPEEVRLYCVQDVHFLPRLWAHYAAKLTRTWEDKVREASRDRVALSQSPGFNGKGRHMAVAPAGWTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PRZ7</accession>
    <name>A0AAN6PRZ7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Branched-chain-amino-acid aminotransferase</fullName>
            <ecNumber evidence="11">2.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">C8A01DRAFT_31532</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-isoleucine + 2-oxoglutarate = (S)-3-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:18321"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-valine + 2-oxoglutarate = 3-methyl-2-oxobutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24813"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.42" evidence="11"/>
    <dbReference type="EMBL" id="MU854320">
        <property type="protein sequence ID" value="KAK4044219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PRZ7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004084">
        <property type="term" value="F:branched-chain-amino-acid transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01557">
        <property type="entry name" value="BCAT_beta_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.10.10:FF:000004">
        <property type="entry name" value="Branched-chain-amino-acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.10:FF:000005">
        <property type="entry name" value="Branched-chain-amino-acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018300">
        <property type="entry name" value="Aminotrans_IV_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005786">
        <property type="entry name" value="B_amino_transII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033939">
        <property type="entry name" value="BCAT_family"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01123">
        <property type="entry name" value="ilvE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009897">
        <property type="entry name" value="PRK13357.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825:SF44">
        <property type="entry name" value="BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825">
        <property type="entry name" value="SUBGROUP IIII AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006468">
        <property type="entry name" value="BCAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00770">
        <property type="entry name" value="AA_TRANSFER_CLASS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 11 12" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7 11" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR006468-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK4044219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="415" mass="46329" checksum="C4668725DC8E1FA4" modified="2024-10-02" version="1">MMRRLLPRCAPRAAAFAFVAPRRSPLGLFQAARQYSITPEVASETKLLDIDPAQLVLNRTSAPKPLKKAEELVFGRNFTDHMLTIEWNQATGWQKPHIVPYQNLSLDPASCVFHYAFECFEGMKAYKDSAGQIRLFRPDRNMERFNKSAARIALPNFNSTAMIDLIAQFTKLESRFIPEERGYSLYLRPTLIGTQKTLGVGPPGSALLFVIASPVGPYYPTGFKAVSLEATDYAVRAWPGGVGDKKLGANYAPCIVPQREAMSRGFQQNLWLFGEEEYATEVGTMNFFVAIKNKQTGQKELLTAPLDGTILEGVTRDCVLSLARERLAPEGWNIVERKYTMRELDEAASEGRLIEAFGAGTAAIVSPVRAISWRGKLVSCGLKEHEESGEIATKMKNWIEARQYGDDAHEWSYVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SKJ2</accession>
    <name>A0AAN6SKJ2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_41788</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854705">
        <property type="protein sequence ID" value="KAK4031766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SKJ2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4031766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="248" mass="27777" checksum="66F4A9528D9E060D" modified="2024-10-02" version="1">MCAPSDPPAPAQSDAGPDEEQLTVRPAPPPAAFAEPPVEPEPVKLVYKDRGDEEDASPRYDPDSPRRYRLLVPIRLPFALRPDEVAPPPYYPPPGTHCDGLALHRDAHLAVLRPVLAGALRALLGPDVLVHRMVDAAVVEEHHESAYVSDRAVNFDLEAGWFRDQYGDEGRVIDAYWDFGDSVCVVQFFEFRLSWRVGADDVDPPIVTLRARDGPDTDGQAVFDVTEAPEWLRSWYNRHIRESGNWDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SKJ6</accession>
    <name>A0AAN6SKJ6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_41767</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854702">
        <property type="protein sequence ID" value="KAK4031781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SKJ6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4031781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="260" mass="28397" checksum="C94B8565D67DAEF0" modified="2024-10-02" version="1">MPTKGHHRSRSSIDRVIDLLADLEETQITVLLDDLNHTTSSNVPVTDAIALFEHHASKPKRRSCRSPSPMRTLQAELERRHSKRLSKRISSAPEPRPFSRIAASQPPAPREPAAAPPAPVTQHFDRPHSPDCPALSLSPPASVERPRSSAGSPPVFQPRSYKRISRPMFLSPTATAELHLLLLAFFNETPVSPATTATPSPTTPLFGFSHSPFTDFEVEPSTPGLDLLEPSPTRAPSFSAGRSLKAMPSIGSIFEVFRSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAN6SLF5_9PEZI</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_40814</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854580">
        <property type="protein sequence ID" value="KAK4032726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SLF5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="43"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="104"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="206"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="732"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="521"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="152"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="170"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="269"/>
            <end position="305"/>
        </location>
    </feature>
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        <location>
            <begin position="307"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="332"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="403"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="737"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="792"/>
            <end position="808"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4032726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="994" mass="113764" checksum="CCFF09D80FA7633E" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SLG9</accession>
    <name>A0AAN6SLG9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_21305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854795">
        <property type="protein sequence ID" value="KAK4031470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SLG9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042891046" evidence="1">
        <location>
            <begin position="17"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4031470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="72" mass="7770" checksum="CE9B7C49DDF43B65" modified="2024-10-02" version="1">MKGIHVVAFLFAAAFAAPLNQSRGSCGNSKRETGVVARVLLSALDTLKDKREVTEVDVDEISQALYSSWCTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SMG9</accession>
    <name>A0AAN6SMG9_9PEZI</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_40855</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854582">
        <property type="protein sequence ID" value="KAK4032713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
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    <feature type="chain" id="PRO_5043052338" evidence="2">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4032713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="184" mass="18529" checksum="864CB7D233D47C81" modified="2024-10-02" version="1">MKTAVIAAALAFAIGASATVKIEHGTDGSFKAISVPTVPDTLATPLKKLARSAGCSSCRDRCLKAVISASNATPEFCTSFLAATYTAPADFAPIQTQCAGAASRVSSACSCFVKPTPSPSTTSTSSTETSSTSSATPIIPSCSPPGGHCTLDTFIQDCCSPDGSGSGMGCYFATGDPQNGVCFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SMJ3</accession>
    <name>A0AAN6SMJ3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">U-box domain-protein 33</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_19874</name>
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    <organism evidence="3 4">
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        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854549">
        <property type="protein sequence ID" value="KAK4033149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SMJ3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="227"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="654"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="658"/>
            <end position="670"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4033149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="702" mass="77960" checksum="3EF6850A18524088" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SNW6</accession>
    <name>A0AAN6SNW6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Dihydrodipicolinate synthase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_49050</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DapA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854473">
        <property type="protein sequence ID" value="KAK4034589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SNW6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00408">
        <property type="entry name" value="DHDPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128:SF47">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="2">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4034589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="323" mass="33889" checksum="63E4E8BD424E2C16" modified="2024-10-02" version="1">MSPRVSVPPSGVWCPAVTLFDPSTDTLDLAAQARYFSYLGTQTGLAGLVILGTNAETFLLTREERKELLVLARTTLGPEFPLMAGVGGHSTAQVREFVADAAEAGVQWVLVLPPGYFGKVGGLGEVVGGFYEEVVKQCEAIGLGVVVYNFPGVCGGVDLDSETIAGLVRKHESVVGVKLTCGSVAKITRLAAEFPPERFAVFGGQSDFLIGGLAVGSAGCIAAFANVFPKTIVEVYNLYKAGKTQEALALHRKAALAEQALKSGGIAATKYAASVFTAPLAGVEDAENKMMPRRPYLPPGEEAKRKIKEALAEVAGIETGIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SNY0</accession>
    <name>A0AAN6SNY0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_39431</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854495">
        <property type="protein sequence ID" value="KAK4034095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SNY0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4034095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="127" mass="12855" checksum="F7D354007BED8F9E" modified="2024-10-02" version="1">MAPTTAPKAQQGHDASRNGNTEPPSHEPPAPSPSSSSVGDNLAQALRDLARGEQTASTLEANLTSLESKLDEILASFGVSAEDLDALDEQEEKKKKTRKDGKDGEGKGAAAAAASEASEGKKGGGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SP57</accession>
    <name>A0AAN6SP57_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Synaptobrevin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">C8A01DRAFT_48807</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the USE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854461">
        <property type="protein sequence ID" value="KAK4034919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SP57"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019150">
        <property type="entry name" value="Vesicle_transport_protein_Use1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13050">
        <property type="entry name" value="USE1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13050:SF7">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN USE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="135"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="52"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="164"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="175"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="185"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="229"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK4034919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="356" mass="38736" checksum="3976EBA5E1B199C8" modified="2024-10-02" version="1">MARLIPGVTATPIPRRADPLTDLTLLLGRLQRTILHADAEREARLREGEFEREKARANINYARSLLTKLEQEALAVKIHARRQEAQADLVRKREVLDQLSERLSDLAEFAAAGNNGDGVDEDTSDGEDILADIIATPSESMDSIRSPDMPPDESNEPSDQIPGPLEPPSHPPSQPESQNNTTPQPTHPPTTTAPPPTTTTSQALRPRHPDPTPSSTQPPPRATTTATSLFSTHPSQKQNPPSTTTAISATEEAILDHQRAAQDALSESILKLASELKASSHAFSASLDEDKAVVDRAGQGMSKTGQNMEGVARKMGMLQRVTEGEGWWGRLRLYVIVYGLMVVLVVVVFLGPKLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SP73</accession>
    <name>A0AAN6SP73_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_18721</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854478">
        <property type="protein sequence ID" value="KAK4034483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SP73"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4034483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="163" mass="18059" checksum="E818BEDF16E72A4E" modified="2024-10-02" version="1">MDVGESKTRPTPTKSSAGRRSKPSLPAITATDAADAPSPCSSIDQDDGTDDTEEPAPHTQHVRRRQNRVGKRHRDKLSAGFERLEVTLGLGDAESRGDGLGGGDQDGLPDAEEQSRRRKRRRPINKAKILDLTCERVQVLLQEWETVKAEREALRKARVLEGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SPF5</accession>
    <name>A0AAN6SPF5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_18549</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854469">
        <property type="protein sequence ID" value="KAK4034680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SPF5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050791">
        <property type="entry name" value="Aldo-Keto_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625">
        <property type="entry name" value="AFLATOXIN B1 ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625:SF7">
        <property type="entry name" value="REDUCTASE (YAKC), PUTATIVE (AFU_ORTHOLOGUE AFUA_8G01560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="16"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4034680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="335" mass="37030" checksum="5CAB8000C1BF069B" modified="2024-10-02" version="1">MVKTLPFGDIEIPVPGFGAMGFNHGLGTNLTLEQAEPVLLKALELGCTFWDTAVIYGAGVNEKLLGDFIRKHNCRDKIFLASKCGIVLPSKALDMSTPQMTVTNKPSHIREYIEGTIERLGSAPDLYYLHRIDPNTSLEESIPVLDELRRRGKTKYIGLSECSAATLRKAHSIAKIDAVQAEYSAFETLHETDGLIDAARELGVAYVAYGPLGHGWLVDDFAYNSPDDFAPNDGRRSIPKFQGENFYKNRAIVGEMQKLAAKKGCTTTQVALAWVAAQGFLAIPGTTKAHRLEENWASREVELTEAEMAEMRRIVEEAKPQGNRYSETLQKMVGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SPH4</accession>
    <name>A0AAN6SPH4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cytidine deaminase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_38254</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidine and deoxycytidylate deaminase family. ADAT3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854449">
        <property type="protein sequence ID" value="KAK4035294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SPH4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052717">
        <property type="term" value="F:tRNA-specific adenosine-34 deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01285">
        <property type="entry name" value="nucleoside_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079">
        <property type="entry name" value="CYTOSINE DEAMINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079:SF156">
        <property type="entry name" value="INACTIVE TRNA-SPECIFIC ADENOSINE DEAMINASE-LIKE PROTEIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="3">
        <location>
            <begin position="198"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4035294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="414" mass="46336" checksum="FEFE337FE33EA19A" modified="2024-10-02" version="1">MDEEDRSIKRSLAAQDPIVRELVQDDVEHGVLIPLKTTLELRDDYQTGHVLITRTPTKTANPAILLLRSLLPDEIIKGVPHLRRCAKPSDLPAHLKAQFMNESPQSRQIHTGKSNWIYIIVGPENMLNRDEVIRALSSLEGMEEDVFLRRIPVPMVSPTSQVQAAMWSQHFWPALYRKNNPLGPHPSMIARQTDEIADDAAIWMTLAHKVAKESQDAGYGEPMGACIIQRDEGKTTLVALAGDFRWCQQGKVGCTGNPMAHAAMRAISIVAQKLVRAENRKTQTSQAPILEFEAFQDSPTLADEKAVFELEHPNPDGYLCHGLEMYLTHEPCVMCSMAILHSRMGKVVFRHRMPLTGGLCAEDRGRDHPALKGADGGRGLGLFWRRELNWSMVAWEWESSGCLKPLRVDTAIHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SPI2</accession>
    <name>A0AAN6SPI2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Dihydroxy-acid/6-phosphogluconate dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_18332</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IlvD/Edd family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854460">
        <property type="protein sequence ID" value="KAK4034962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SPI2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.80">
        <property type="entry name" value="IlvD/EDD C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042096">
        <property type="entry name" value="Dihydro-acid_dehy_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020558">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056740">
        <property type="entry name" value="ILV_EDD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000581">
        <property type="entry name" value="ILV_EDD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037237">
        <property type="entry name" value="IlvD/EDD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052352">
        <property type="entry name" value="Sugar_Degrad_Dehydratases"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004784">
        <property type="entry name" value="PRK06131.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43183:SF1">
        <property type="entry name" value="HYPOTHETICAL DIHYDROXY-ACID DEHYDRATASE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43183">
        <property type="entry name" value="HYPOTHETICAL DIHYDROXYACID DEHYDRATASE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24877">
        <property type="entry name" value="ILV_EDD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00920">
        <property type="entry name" value="ILVD_EDD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143975">
        <property type="entry name" value="IlvD/EDD N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00886">
        <property type="entry name" value="ILVD_EDD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase N-terminal" evidence="7">
        <location>
            <begin position="66"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase C-terminal" evidence="8">
        <location>
            <begin position="398"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF24877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4034962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="621" mass="65564" checksum="6FED705D79C20522" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SQ47</accession>
    <name>A0AAN6SQ47_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_37921</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854438">
        <property type="protein sequence ID" value="KAK4038150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SQ47"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.63.20:FF:000001">
        <property type="entry name" value="40S ribosomal protein S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.63.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004977">
        <property type="entry name" value="Ribosomal_eS25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12850">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03297">
        <property type="entry name" value="Ribosomal_S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4038150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="97" mass="10736" checksum="F2AF3EBB7F18B16C" modified="2024-10-02" version="1">MAPAAAGAKKQKKKWSKGKVKDKAQHAVILDKATSDKLYKDVQTYRIVTIATLVDRLKINGSLARRCLKDLEEKGQIKQVVGHSKMKIYTRAVGAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SQ60</accession>
    <name>A0AAN6SQ60_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_17708</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854437">
        <property type="protein sequence ID" value="KAK4038195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SQ60"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006598">
        <property type="entry name" value="CAP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051091">
        <property type="entry name" value="O-Glucosyltr/Glycosyltrsf_90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203:SF61">
        <property type="entry name" value="CAPSULE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203">
        <property type="entry name" value="KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05686">
        <property type="entry name" value="Glyco_transf_90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00672">
        <property type="entry name" value="CAP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase CAP10" evidence="2">
        <location>
            <begin position="537"/>
            <end position="828"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4038195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="837" mass="90162" checksum="A73F714F299D5DC2" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SQH5</accession>
    <name>A0AAN6SQH5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glutathione S-transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_36640</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854402">
        <property type="protein sequence ID" value="KAK4039349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SQH5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00299">
        <property type="entry name" value="GST_C_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00570">
        <property type="entry name" value="GST_N_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050983">
        <property type="entry name" value="GST_Omega/HSP26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968:SF13">
        <property type="entry name" value="GLUTATHIONE TRANSFERASE OMEGA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13410">
        <property type="entry name" value="GST_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="27"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="3">
        <location>
            <begin position="127"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4039349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="291" mass="32983" checksum="AB6E70E852F38C8F" modified="2024-10-02" version="1">MSTIDTTLLPHPTGAAATLAAAHATPHPLQLYGGWFCPFVQRAWIVLAEKRVPHQYVEINPYKKEPHFLALNPRGLVPTLAVEVGGGEKKRRALYESTVICEYLDESYSDEGQYGARLLPAGSGEGEVYERARCRLWINHVVTRVVPGFYRLLQHTPEKGYPIEEARTEFLKGVREFAREMVDSGSGKSGPWFLGERFSLVDVMLAPWAKRLFLIDHYKPGGVGIPKKGERGEDEEVWARWDEWFGAIVERESVKATWSEEEKYIEAYKRYAEDTTQSEVGQATRQGRSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SQU9</accession>
    <name>A0AAN6SQU9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mating-type switching protein swi10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_47256</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854406">
        <property type="protein sequence ID" value="KAK4039232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SQU9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4039232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="368" mass="41346" checksum="50F550AF3F791CC2" modified="2024-10-02" version="1">MEQRKEGLLATSPGRGPRLRRKLQKCIPRQQTNIVSWVGSSNPAATPETRDPTDNKPTSRTPPRPSPPLRDNRRTLREGRFYQHDPTLETLELLKPQTYVVPEFSHLIPNPQPQAPSSGSESTNPPTPRMRRRAKTPIFSAGQLEDMPRPTNTLGRTSSVDLIAEQYRAVLESQRCSVYSDDSEEPALSPRDSDTDEPPVTLRRRRSSGYLQNEAPLGEYSTTRMVELPNPSPTSDDGTLVSFQDEGTVYFKPLSFSPEPPEESPGSRIPLSRQTSAEDNVSLQICLDLLTRELSSAIAGRPCPSPKDTSALQIWAMIEAYERLRDQMAELSHSNEQARSMEMMFDMWLRALYSIHDTMAAGAREEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SSD8</accession>
    <name>A0AAN6SSD8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WKF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_35704</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854380">
        <property type="protein sequence ID" value="KAK4040283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SSD8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019327">
        <property type="entry name" value="WKF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22306">
        <property type="entry name" value="CHROMOSOME 7 OPEN READING FRAME 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22306:SF2">
        <property type="entry name" value="CHROMOSOME 7 OPEN READING FRAME 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10180">
        <property type="entry name" value="WKF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WKF" evidence="2">
        <location>
            <begin position="140"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="390"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4040283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="429" mass="46123" checksum="88A99E607535B9BC" modified="2024-10-02" version="1">MSAHVPAWKRLGLKLKGPASGEAIPSPAGPNARAKPAAQVPSAHQARVNGSPASSLKRKLPSSASTPNAASATPNKKPRRGDQSAADQGTPPSLRKSVSFADDTKASAKDKPEKKKAKKKKTTKASDAPKTDFSLEPSLNYIRQWHTARASWKFNKNHQTLLIKYLFDGDKVPSADIPIFYQYIRDLKGFVRTRLRETAAEIKQKDMDAGAGAFPAALKDKETKQKQYEETISRFLQDLHQHQQQRREPNGSASSKNANGKRTLDEVEYVLRIATPEVKQRLLKRIRAELVVDELSDSEESTATATSSTSSSSASTAAAAVDGTITTTATGRSDGSQQPAKRRRLRNVRTDIGDDDSSSSESESEESESEGSSSDSDESEDEMDVDVAPDAAAAAESSSSSSSSSEAESGSEDDDDDESGEESSSSDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SSQ3</accession>
    <name>A0AAN6SSQ3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF967 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_34225</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854352">
        <property type="protein sequence ID" value="KAK4041734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SSQ3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072380">
        <property type="term" value="C:TRC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006620">
        <property type="term" value="P:post-translational protein targeting to endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.150:FF:000005">
        <property type="entry name" value="UPF0303 protein Ping_1243"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.150">
        <property type="entry name" value="Haem-degrading domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005624">
        <property type="entry name" value="PduO/GlcC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038084">
        <property type="entry name" value="PduO/GlcC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010371">
        <property type="entry name" value="YBR137W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28255">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28255:SF1">
        <property type="entry name" value="UPF0303 PROTEIN YBR137W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03928">
        <property type="entry name" value="HbpS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143744">
        <property type="entry name" value="GlcG-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4041734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="195" mass="20386" checksum="E8F1E401A5505EEA" modified="2024-10-02" version="1">MALAAPTTDPAVLLAQETSDAYTFRSFTAETAWALGTALRGRLLSLPAGQRKPALISIALAGGTPLHVVFQSATEPGTVPDNENWVRRKRNTVLRWGVSSWAMRMKTKAGLGGGGVGVTADEIEAAFVKKYSLASSNGGAVADEYAIHGGGFPVRVRGVDGVVAVVVVSGLKQEDDHAVVAETVKELVAAQCEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SST8</accession>
    <name>A0AAN6SST8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_15346</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854369">
        <property type="protein sequence ID" value="KAK4040806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SST8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052742">
        <property type="entry name" value="Mito_N-acetyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015416">
        <property type="entry name" value="Znf_H2C2_histone_UAS-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43138">
        <property type="entry name" value="ACETYLTRANSFERASE, GNAT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43138:SF2">
        <property type="entry name" value="PROTEIN SPT10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09337">
        <property type="entry name" value="zf-H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="79"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="509"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="577"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="374"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="514"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="532"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="586"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="613"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="645"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="696"/>
            <end position="705"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4040806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="740" mass="81401" checksum="2E306519CF17FE91" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6ST36</accession>
    <name>A0AAN6ST36_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_34397</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854355">
        <property type="protein sequence ID" value="KAK4041557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6ST36"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4041557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="258" mass="29227" checksum="95464EBEB099A96F" modified="2024-10-02" version="1">MARTYRILHRPWRAKAPLYWGMVPELAGVIALLVLFGLQQPDSFRTRFWQIGFDNKLNSNPKMILYAYANYQPLPTVPFVWSRTLTNFNVAISVVSLFILLAKMIATIMKVFYPIFGTIIGLGLTALYTVSVYGQAGPDYADPRYPSPTPWHLRLGCKLAEAYNMGKTCQMVQATLGMTVYMLALYLFQSGFAIWAMLPNKEIDMYDSDDEDEYGSAAAKNKGVAVQMQPTPPNEQVPFTPRTQAFHALERKLPLRYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6STA0</accession>
    <name>A0AAN6STA0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_14578</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854352">
        <property type="protein sequence ID" value="KAK4041752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6STA0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="222"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4041752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="452" mass="47903" checksum="04918B35BCB5AEC4" modified="2024-10-02" version="1">MPTPTHAPPPPLSHSQEEASNSYSSHFPLSPLPASLLLDRELARKEVLAGRGNPITTGCSELDDYVLLGGFERGSVVGVSAEGEEVGVLIGLQTVARLLATQSAARAVVVTTLPAAVLLPKLRGAIVGQLALAGLEGGMQDLESRVGGCLERVSIARVFDVEGLWEVLREVEEVVTAEDGPPKERATGRGEQRTEVLDSEDEGGLSSPEPPTPSPPQPDAPQNPTHNPTATQPPTTPPDMILITHTSTLLNALFTGRDKEAAHNTMLLLTSHLHALTRSPSHGSPLIMLLNSTTSPPIPHRGTDDGTAPATDGGYRPPPKQLDPTLRSIFNTPPPGPPPPAPQAMLNFASGARRNKPSFGLVFSQMLDLHLLCTRVPRTRADSSVLAASPGAADGVSYVWAVEVLLDEMGVYDERAGDGGCEWGVVVRRRCREQRWGVVDVDGEGRVVNAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6STG0</accession>
    <name>A0AAN6STG0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Lytic polysaccharide monooxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_14616</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854353">
        <property type="protein sequence ID" value="KAK4041675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6STG0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36182:SF2">
        <property type="entry name" value="LYTIC POLYSACCHARIDE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36182">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042884967" description="Lytic polysaccharide monooxygenase" evidence="2">
        <location>
            <begin position="19"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="235"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4041675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="262" mass="26956" checksum="FA8A84F5A9CE17EA" modified="2024-10-02" version="1">MIFTQAFVVAALVSLSEAHMKLRLPTPFEGLEKVNAPILADGTNYPCHTDKGPFKGTPTKMEKGSKQQLGFTGTAVHGGGSCQISITYDEVPNASSSFKVIHSIQGGCPARNQKGNIEPANEFAVSPDTYDFTIPDDIPSGKATLAWTWFNKIGNREFYMSCAPVEISGSGGSESALASLPDMMIANIPQAGTCKTADSTDIQFPNPGKSVENNGGNMAPPTGECKAGGSGSGSASGSATPAAGAGAAATPAVRGRRAVLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6STH8</accession>
    <name>A0AAN6STH8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peroxisomal ATPase PEX6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Peroxin-6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">C8A01DRAFT_13873</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Interacts with PEX1; forming the PEX1-PEX6 AAA ATPase complex, which is composed of a heterohexamer formed by a trimer of PEX1-PEX6 dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Peroxisome membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
            <orientation evidence="7">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854339">
        <property type="protein sequence ID" value="KAK4042559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19527">
        <property type="entry name" value="RecA-like_PEX6_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000109">
        <property type="entry name" value="Peroxisomal biogenesis factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000039">
        <property type="entry name" value="peroxisome biogenesis factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056995">
        <property type="entry name" value="PEX6_4th_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047533">
        <property type="entry name" value="RecA-like_PEX6_r2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF9">
        <property type="entry name" value="PEROXISOMAL ATPASE PEX6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23315">
        <property type="entry name" value="PEX6_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23120">
        <property type="entry name" value="PEX6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="1027"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="256"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="294"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1372"/>
            <end position="1436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="301"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="1377"/>
            <end position="1388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="1423"/>
            <end position="1436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00062700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK4042559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1436" mass="153623" checksum="CA7862D9229A9532" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SUE6</accession>
    <name>A0AAN6SUE6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Store-operated calcium entry-associated regulatory factor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Transmembrane protein 66</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">C8A01DRAFT_32433</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SARAF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854327">
        <property type="protein sequence ID" value="KAK4043504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SUE6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006816">
        <property type="term" value="P:calcium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001256">
        <property type="term" value="P:regulation of store-operated calcium entry"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009567">
        <property type="entry name" value="SARAF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15929">
        <property type="entry name" value="STORE-OPERATED CALCIUM ENTRY-ASSOCIATED REGULATORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15929:SF0">
        <property type="entry name" value="STORE-OPERATED CALCIUM ENTRY-ASSOCIATED REGULATORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06682">
        <property type="entry name" value="SARAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 16" id="KW-0732">Signal</keyword>
    <keyword evidence="6 15 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042943487" description="Store-operated calcium entry-associated regulatory factor" evidence="16">
        <location>
            <begin position="28"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="189"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="228"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="238"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="266"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="276"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="300"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="311"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00031116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAK4043504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="323" mass="32913" checksum="D22E8C5B1F912692" modified="2024-10-02" version="1">MRFDPGTTVSLLLSLLTFSALPSGALAARPKNAVLLSEVQSLTLRSPLKTTARRVSAIPQLKCVSPLPLCRLTPTIQTMRCTNAGASYTSQDIAWSCTATLPSTLRLDSTEVICEGYSSPDDAYVLKGSCGVEYTLALTDEGREKYPHLVGSKTKEGGLDWAGFFFWVLFIAVVGVIVYAALIEARDGVDNNNNTNNNRRRPGGGGGGGGGWGPGGGGGGGGGGRWNDPPPPYPDPKPSSSSASGSWSPGFWTGLATGSAAGYAAGNRGQRNNGQNNGGSGGWGSGSGSGSGSGWGGGRSSSPGNSGSGTPHESTGYGSTSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SUJ9</accession>
    <name>A0AAN6SUJ9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_33269</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854338">
        <property type="protein sequence ID" value="KAK4042608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="367"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="147"/>
        </location>
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            <begin position="1"/>
            <end position="20"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <begin position="135"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4042608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="420" mass="47290" checksum="1F1318EC9969ABBD" modified="2024-10-02" version="1">MPETAADQQPGTGDDATTGTLPADERAPGPRLSLPQRAPIEPFTKQELTVRLSRDLRGAEFSEVIRQENQCIRSRVKVVSHSLTRGEDANVNVITTPAEPAPAGSSAAFPYPADYREVIQRRSDNPSVDEEGTVGRDNTNTNNADGGNDTTWRVFEIARHLGISPAKLFKVLRQPEPPRRRRNVKADRSMLGYHLQVVRQQEWSYQRKDTSNVNISVSKAVGKIVQVTVRPVYVVVGIFPRGHSHHPLETAVFVPRPERLFWRLRWAVFRLRGWQGTFLSLRHVKAVRLYQCDRSSGNHRRVELDDNGLADLQLFLDTYNRHWYGVPSEITLAWAAWIHQALNNNSHNVEDGTYALELVLDWSVARITFVVLLPVLLSLAVGVWLNARDWTDLATIQTAWGTASYVVTAGGCEFFYEGPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SVH2</accession>
    <name>A0AAN6SVH2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Helicase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_12685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854324">
        <property type="protein sequence ID" value="KAK4043760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SVH2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42345:SF2">
        <property type="entry name" value="HELICASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42345">
        <property type="entry name" value="TPR_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="569"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="789"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="965"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="970"/>
            <end position="982"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4043760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1066" mass="116872" checksum="9D6E73100BF83891" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SVP5</accession>
    <name>A0AAN6SVP5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_31619</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854320">
        <property type="protein sequence ID" value="KAK4044302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SVP5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF68">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01120)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="399"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="436"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="463"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="60"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4044302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="500" mass="53700" checksum="6517A3E171BC4FA2" modified="2024-10-02" version="1">MSSSTSSTIPGLNSGHDGALAEPKVESSSSEGDGGDVIDWEGDQDPECPYNWPRRKIVTNSTILSILTFLIPLSSSIIAPGVPELMVEFHNTSQILAAFVVSVFVIGLAVGPLLLSPLSEIYGRLIIYHVAMVGFVAFTIACALAPSLESLIVFRLLQGALGSCFVTNAGASIADMVPSHRRGTYLAAVSAGTLLGPIIGPVIAGFLNDARGWRWIFWLVTIVGGAAGLAMLALGRETYHPLILQRKVDRLRKLTGNPKLRHRLDDGLTPAARLRRGIVRPVRLFWTPIGIVCALYMTVVYGYLYLMFSSVTTVFQDQYNIRGKLSGLVFLGLGIGNLIGMVLTSVTTDRAIKNRIANGAAGPEAVPPEVRLTLTPYGSVLLPAGLFIYGWTAQYKVHWIIPIIGMAVMGVGNMIIFLSISLYLIDCYGIYSASALAANTVVRSIGGGVLPLAGLRMFSALGIGWGTSLLGFIAVAMIPIPVLILRYGERLRRRQDMTNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SVT1</accession>
    <name>A0AAN6SVT1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_12483</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854321">
        <property type="protein sequence ID" value="KAK4044090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SVT1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="377"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="204"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="431"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="252"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="334"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="464"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="487"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="499"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4044090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="522" mass="55535" checksum="62149AD532CEF909" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SVV4</accession>
    <name>A0AAN6SVV4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Derlin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_12523</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Endoplasmic reticulum membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the derlin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854322">
        <property type="protein sequence ID" value="KAK4044046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SVV4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007599">
        <property type="entry name" value="DER1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11009">
        <property type="entry name" value="DER1-LIKE PROTEIN, DERLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04511">
        <property type="entry name" value="DER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4044046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="245" mass="28396" checksum="007FC80E0AC6D7A0" modified="2024-10-02" version="1">MDQIMGGEGGFPLETWFWEMPICTRWWTTATVLTSGLVQCQLVTPFQLFYSYRTVFHKSEYWRLLTTFLYFGPISIDLLFHVYFLQRYARLLEESSGRSPAYFSWLLVYAMTSLLLLSPFVSMPFLGHPLSSTLVYIWSRRNPDTLMSFLGLLVFRAPYLPWVLMGVSYVLHGSVPKDEFMGVVIGHVWYFFNDVYPPLHGGSRPLDPPMWWRRLFEGRPRDDTANGINNEIAVAGAEVPPPEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SVX4</accession>
    <name>A0AAN6SVX4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">C8A01DRAFT_31330</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the proteasome complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the peptidase T1B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854318">
        <property type="protein sequence ID" value="KAK4044542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SVX4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03761">
        <property type="entry name" value="proteasome_beta_type_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000013">
        <property type="entry name" value="Proteasome subunit beta type-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF3">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="6 11" id="KW-0647">Proteasome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0888">Threonine protease</keyword>
    <keyword evidence="7" id="KW-0865">Zymogen</keyword>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600243-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK4044542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="285" mass="31329" checksum="5963067106CF510D" modified="2024-10-02" version="1">MDTLVARYSRPAYQQNEAFSEQEQQDLVDGVPSLSLKFAMPPVAHPSAWLRAATDDRSNPSCPIKIAHGTTTLAFRFQGGIIVATDSRATAGNWIASQTVKKVIEINSDLLGTMAGGAADCQYWLAWLGMQCRLHELRHKRRISVAAASKILANLVYQYKGMGLSMGTMCAGVTKEEGPALYYIDSDGTRLAGDLFCVGSGQTFAYGVLDSEYRWDLSTEEALELGSRSILAATHRDAYSGGFINLYHVKESGWEKHGFTDTNPVFWKTKLEKGEFSNVTSDFTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SW49</accession>
    <name>A0AAN6SW49_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tudor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_12329</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854320">
        <property type="protein sequence ID" value="KAK4044273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SW49"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd20446">
        <property type="entry name" value="Tudor_SpSPF30-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041297">
        <property type="entry name" value="Crb2_Tudor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46297:SF2">
        <property type="entry name" value="TUDOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46297">
        <property type="entry name" value="ZINC FINGER CCCH-TYPE WITH G PATCH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18115">
        <property type="entry name" value="Tudor_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tudor" evidence="4">
        <location>
            <begin position="97"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="47"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="155"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="250"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="164"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="255"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4044273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="298" mass="32553" checksum="D368F39187D12420" modified="2024-10-02" version="1">MSAQLETERKEYESQLELVSTSLRDDPDNAELQGLRSELEQMIQLLDDSLAELKPKNDAPKRAPSPPPAEQKWSRENHPAFKKAAPAEEKEKEPEVIAYQVNDNVMAKWLSGDKGFYPARITAVTGSSTAPIYTVRFKSYDTVETLRAKDIRPVAQKRKADGTAVSSNSTAVGGSASTAAASPSSLTPTSANNGIVMSAAADMYPQAQAANKAAAESNDDKPRPKFKKIKATKELEKGKNKWQEFAAKGKLGKAGKKESMFRTPEGIHGRVGFTGSGQSMRKDPTRSRHVYQPNEELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SWH9</accession>
    <name>A0AAN6SWH9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">G-protein coupled receptors family 2 profile 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_31026</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854316">
        <property type="protein sequence ID" value="KAK4044840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SWH9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF22">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05462">
        <property type="entry name" value="Dicty_CAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="353"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="395"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="7">
        <location>
            <begin position="13"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="245"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="301"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="437"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="479"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="308"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="457"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="505"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4044840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="533" mass="57950" checksum="0C5BE542E13A33D6" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P432</accession>
    <name>A0AAN6P432_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_42206</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854866">
        <property type="protein sequence ID" value="KAK4031329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P432"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052974">
        <property type="entry name" value="GH79_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031728">
        <property type="entry name" value="GlcAase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183">
        <property type="entry name" value="BETA-GLUCURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183:SF3">
        <property type="entry name" value="BETA-GLUCURONIDASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16862">
        <property type="entry name" value="Glyco_hydro_79C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043038209" evidence="1">
        <location>
            <begin position="21"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-glucuronidase C-terminal" evidence="2">
        <location>
            <begin position="377"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4031329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="486" mass="51326" checksum="9AB4CFC71CD03089" modified="2024-10-02" version="1">MARISQFAVLCAAIAQGVDAAVTFAVPSKTGTGGLSYAPLDSAPVGISFEFFAFPSYFTNVTATNQCLSNWKDLTGVWPPIRIGGTTQDRASFDASTSAYVVYSVASPADAPMTLTFGPKFMTLAGTYPGRVVVGLNRGKNNIANTIAAAKVAVSEVKNLLAIELGNEPEYYPKDGQPIASGTWNPSVDATSQVNWNIQVGKALGKTNIIQTGNWNQPPPEWGAAQLIAKENATSKPYVRHYAHHNYPGGDIQKLQTHSQTASNVRSMFAADVAAVKQQTGKEYVLGETNSVAGGGAAGVSPTFGAALWTMDYVLRAATTNISRTYFHHGTVGNCQYCFWGRYSMGAPYYGATAAVALMAGARTIAALDTGANNYAGYATFDGEGKPMRVLLYNSDYYTGSGSRGSQGFTLTGLGGLNGGSVKAKRLTAKSSLARVDRGDDISFGGQYWTNGTCVVGGKEMFETVNVENGQATFDVKAAEALLVYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P512</accession>
    <name>A0AAN6P512_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetylglucosamine-6-phosphate deacetylase</fullName>
            <ecNumber evidence="2">3.5.1.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_20975</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>N-acetyl-D-glucosamine 6-phosphate + H2O = D-glucosamine 6-phosphate + acetate</text>
            <dbReference type="Rhea" id="RHEA:22936"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="EC" id="3.5.1.25"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. NagA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.25" evidence="2"/>
    <dbReference type="EMBL" id="MU854686">
        <property type="protein sequence ID" value="KAK4031876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P512"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008448">
        <property type="term" value="F:N-acetylglucosamine-6-phosphate deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006046">
        <property type="term" value="P:N-acetylglucosamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00854">
        <property type="entry name" value="NagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000065">
        <property type="entry name" value="N-acetylglucosamine-6-phosphate deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003764">
        <property type="entry name" value="GlcNAc_6-P_deAcase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11113">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-6-PHOSPHATE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11113:SF14">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-6-PHOSPHATE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="9">
        <location>
            <begin position="67"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="136"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="196"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4031876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="463" mass="49402" checksum="7A30411AB34F573E" modified="2024-10-02" version="1">MPSAVRSASPRHNGITKLTNCRLVRGDDLVWDDVWVSSATGKIIRSQSAFYDELIMPDEVIDLGGRIVSPGFIECQLNGAYGFNFSTATDDMAQYGKQLRDLNKKLAQTGVTSYIPTVTSQTSDLYKKVLPYLGPSGSSRRPHDGAESLGAHVEGPFLNPTKNGVHNPSVLRVASSFADLEEMYGAANLTPPSFQGSKPPTSGSSSSPEIPIKMITAAPELGAMTDLIPALTARGILVSIGHSEATYEEASAAVSAGATMITHLFNAMRPLHHRNPGIFGVLGATEQPHHSHSQPDQAEQKKKRPYFGLIADGIHLHPATIKIAWHAHPAGLILVTDAMHMVGLPDGRYPWTNGEGEHYIVKKGSVLELEGTGVIAGSSTTLTTCLTNFLAATDATIPQALRAVTATPAAMLGVAGIKGCLDAGADADLVVLSEHETDGEVGRRRELVVDEVWKFGVRVFERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P5B7</accession>
    <name>A0AAN6P5B7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_41535</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854659">
        <property type="protein sequence ID" value="KAK4032041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P5B7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007300">
        <property type="entry name" value="CidB/LrgB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30249:SF0">
        <property type="entry name" value="PLASTIDAL GLYCOLATE_GLYCERATE TRANSLOCATOR 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30249">
        <property type="entry name" value="PUTATIVE SEROTONIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="237"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="293"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="361"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="390"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="168"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="208"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4032041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="454" mass="48576" checksum="FD3C9F34068AB58E" modified="2024-10-02" version="1" fragment="single">MARRSYQDTSARDELEPKVSIPGFTDGLIALVIALVAQLLIAAIQLGLDQEQSDFPAPIVAMAAVFLVFSVCGCIIPGLEDFYKKRLRRATELLNRHMSVGFTIPVVMLCHGPPSDTHSIGMIIICFVLTGMFNTVLAYFLALPIQCLMVRYDKHFWVDRDADAEKGAEQRATKAPKPAKSFCEGSPSGSSLTIGLDTSAESSETDEPTQPATNSRPNTPRTPLRAHLRTWAIQNPILLLSWLLTLTVGLPLRYRTSNDVALATLLLASTWLTTLALQTTIKSTPLFPPWARTLLSGLANPVLCTALTLTGYVFADAALSARPVPAMLATLQTHTPLSTLILHQTTTPENKMKMNMAAGDLAITLLNSGLVAWGLKLYAHRRHLFSRAGLTVCTVSSMLALANLLCGPLFAARGLGVTPASGALAFAARSVTIALGDPVMGMLGGDGGLNAAMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P6G7</accession>
    <name>A0AAN6P6G7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_41865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854726">
        <property type="protein sequence ID" value="KAK4031687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P6G7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="168"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4031687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="531" mass="59618" checksum="74E99502B3E77A6C" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P6P5</accession>
    <name>A0AAN6P6P5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Non-histone chromosomal protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_50576</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">DNA-binding protein that induces severe bending of DNA. Required for DNA-binding by the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. Also augments the fidelity of transcription by RNA polymerase III independently of any role in the FACT complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NHP6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854584">
        <property type="protein sequence ID" value="KAK4032679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P6P5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01390">
        <property type="entry name" value="HMG-box_NHP6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000016">
        <property type="entry name" value="FACT complex subunit SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050342">
        <property type="entry name" value="HMGB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN DSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112:SF22">
        <property type="entry name" value="MITOCHONDRIAL TRANSCRIPTION FACTOR A, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00886">
        <property type="entry name" value="HIGHMOBLTY12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="8">
        <location>
            <begin position="25"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="6">
        <location>
            <begin position="25"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="69"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00057588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00067275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4032679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="104" mass="11633" checksum="3FD9CEDEE4FF2F4E" modified="2024-10-02" version="1">MPKAAKGRAGKAERKPKTKKDPNAPKRGLSAYMFFANEQRENVRDENPGVSFGQVGKILGERWKALSEKQRAPYEAKAAADKKRYEDEKQAYNAQADGDEDESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P733</accession>
    <name>A0AAN6P733_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_20052</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854562">
        <property type="protein sequence ID" value="KAK4032956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P733"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4032956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="287" mass="29403" checksum="7B4B1C3C55DA66D0" modified="2024-10-02" version="1">MATPSRNSGVYVMSSTTTLVTITTSLGGSTPSTLAASSESTDGRYLNSSAAINSASLTRTPLWANSTSIKTSLNTTASPLRLLNHSTTASAVFSLSNTTRPLWLNTSQTLTSPTPTSTTTTPSLGCDENAIPFTLQVSQPGGQFDKWFLRVSGIGLLFTSAADQAGPFGLGSSGALCAMGVVDQEGAPYVAVVETQASSDGTARGAGGSVWLMARGTLEVRGEDYTPLRCEGSDRGLRCGEAHGGGEMRDWLGCGMQLDLASEDGGAGPGRGLNCTVVELGIVFVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P7C4</accession>
    <name>A0AAN6P7C4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_50313</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854557">
        <property type="protein sequence ID" value="KAK4033024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P7C4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4033024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="345" mass="38167" checksum="72E9532475AC2922" modified="2024-10-02" version="1">MAGPQLDAILDKQHRNVLNGAVRNVLGTELALETCAQIADGLPLARVAYDQYGRRREQGHPVSGHTSLCPGAEEIARDFLSGFAIDRLNFDDQLLQAYQSAPPGHHSFHCRLIELVAVAVHKMAVLLFGQGHRVHDKEPKNATSSIDIVSSWQSRLNREALIPPPGPTLFEHVSYGARDQYPDGVADAVGYWAENIILGGVVLFDRSEAWDDERTPEPNVYLHSDRDGVTFRVWQALDEQQQALVDFLLSSSPVGTCPCPLAASDKNLTRINPEGATEKKVYRDIWEREPPNRRGGFGARGLGGCIMRPLDYPKEALSKLESCLKYYAAFQTPVREKGGVLENFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P867</accession>
    <name>A0AAN6P867_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Anucleate primary sterigmata protein B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_40025</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854525">
        <property type="protein sequence ID" value="KAK4033519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032982">
        <property type="term" value="C:myosin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012943">
        <property type="entry name" value="Cnn_1N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024545">
        <property type="entry name" value="Mto1-like_Mto2p-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615">
        <property type="entry name" value="MYOSIN HEAVY CHAIN, NON-MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615:SF40">
        <property type="entry name" value="MYOSIN HEAVY CHAIN, NON-MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07989">
        <property type="entry name" value="Cnn_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12808">
        <property type="entry name" value="Mto2_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Centrosomin N-terminal motif 1" evidence="5">
        <location>
            <begin position="446"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="Mto1-like Mto2p-binding" evidence="6">
        <location>
            <begin position="1568"/>
            <end position="1619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="97"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="357"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="417"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="516"/>
            <end position="547"/>
        </location>
    </feature>
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            <end position="746"/>
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            <begin position="1300"/>
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            <begin position="119"/>
            <end position="130"/>
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        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
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        <location>
            <begin position="182"/>
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            <end position="232"/>
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            <begin position="233"/>
            <end position="244"/>
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            <begin position="245"/>
            <end position="254"/>
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        <location>
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        </location>
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            <begin position="670"/>
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        <location>
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            <end position="1623"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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        <source>
            <dbReference type="Pfam" id="PF07989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF12808"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK4033519.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1623" mass="178889" checksum="408EDB64BB7E9F57" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P949</accession>
    <name>A0AAN6P949_9PEZI</name>
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        <submittedName>
            <fullName evidence="6">Phophatidylserine decarboxylase-domain-containing protein</fullName>
        </submittedName>
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        <name evidence="6" type="ORF">C8A01DRAFT_50289</name>
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        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
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    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_7G01730)"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="zf-C2H2_3"/>
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    </dbReference>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="737" mass="81538" checksum="CEBE4C536BA04733" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P968</accession>
    <name>A0AAN6P968_9PEZI</name>
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        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_39473</name>
    </gene>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAK4034044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4034044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="404" mass="45533" checksum="585A4E93296BB323" modified="2024-10-02" version="1">METQLTDAGDGERYAYMFKCGDRRFLFIRPFGAGMESVAQLVKDVDSGENLIRKVPARRLVHFLLSDENRRLKKPNEIRMLNAIKKTFKAPEPGLPFYISKCYGHEYIRSKYPDEKGRQMYHSASYWKLCNGDSVRSRWLFDCLYPPPASLIARMIRQVLSTLHYLYTAGDQPLYHDDLHLGNVWIHWPSDTALPDFYLGDFGEACFVDSKFQNHSFAEQIRIAHPVNDLHKFYLNIENLLTTYGMFPGYAAAYGQTGLNALGRLVKAMKGVVTDWETAANTLEPPDLKPLIQWAKDVEEMFGEGGGVDETQSEAYTGFVTEERKVALQFQHEKPLIVSGSKQEALRPMVMDGPGKALLPIHGPWQLVTVDGLPAEGEGVTHHRPNDGRFHPGEPNLAGILGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P9H4</accession>
    <name>A0AAN6P9H4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_50915</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854630">
        <property type="protein sequence ID" value="KAK4032256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P9H4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013744">
        <property type="entry name" value="SidJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31591">
        <property type="entry name" value="UPF0613 PROTEIN PB24D3.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31591:SF1">
        <property type="entry name" value="UPF0613 PROTEIN PB24D3.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08538">
        <property type="entry name" value="DUF1749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4032256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="354" mass="39247" checksum="71F8E375B6965A57" modified="2024-10-02" version="1">MGSKFWPKRGSPGILHHFTESLVAFEFTPNTKSQPHSILFLGGLGDGLATTSYVADVVAGLQSTEWSLFSLTLTSSYQSWGFGHLDRDTDEIAQCIRYIKDYKTAQFGSPGKLVLMGHSTGSQCVLHYLSRPNPHTSTPRFDRGLEHAERPAIDGGIMQAPVSDREAIQLIMRDGFLGRTPSEMRETYDQLVALAREAVGDKDQECDSMLPIPLTAQFGYPRNTPVSCRRFLSLVSPDSPGAPAEDDTFSSDLGDEQLAKTFGMIGQRGLLRHKLMVLMSGADQAVPEWVNKEGLLARWRRATDGDRTTQIWDQERSGLIPGASHALSNDDQAEPRAFLVRRMLSYLADLEKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PAA0</accession>
    <name>A0AAN6PAA0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_39851</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854515">
        <property type="protein sequence ID" value="KAK4033695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PAA0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4033695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="252" mass="27984" checksum="82F92424593001F3" modified="2024-10-02" version="1">MNNEIIASITQWEDEFSSCVAGRALYCELPTEDDAFLSMPLEWLFPTLPPADYKATFTMDNPEPKLLPPGGLGALQPFGFVVIDGPPDKVVSLDRRNGSHMHIIDLDYDPAVLKHQDNETYTARFVYTDDSADSNCDDIHLGGAEGTIVKLPSDCGFTGYGVIHAIEPATDRGTAVSHDLRARAPPNATVHELSFSYDFLRVKRTDESDPVYVRIDYGTQNEYWHAFVDEPADTSPATRRKRNAESIAETRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PAG8</accession>
    <name>A0AAN6PAG8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_18523</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854468">
        <property type="protein sequence ID" value="KAK4034728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PAG8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF288">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="1"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4034728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="257" mass="29018" checksum="F27F1E2DBA359CF2" modified="2024-10-02" version="1" fragment="single">NVISGGSTGLIELLPCGNVRKVTYPESKARRQSLRDIEHEFRVYQRLPRQHDRLLQMIKYSLEDGLVLQYLSAGNLRRHLRQATANITVSQRLQWACDAAEALHLLHTHGIIHCDVKPENFLLDGIYRLKIIDFSGSSYDGKVGSAIEGTRLFLPRSWDDESTVQTDLFALGSTMYEIMTGKQPYKELADDKVEARYAQEIFPSVQSIHCGQIIMDCWRGQIKTVEEAMVSIGAEMETANIPAYSCVPCSPTVCRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PAP4</accession>
    <name>A0AAN6PAP4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_41017</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854598">
        <property type="protein sequence ID" value="KAK4032537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PAP4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="489"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="296"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="489"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4032537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="523" mass="56195" checksum="2EE104681CC985A1" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PC12</accession>
    <name>A0AAN6PC12_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyl hydrolase catalytic core-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_18012</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854449">
        <property type="protein sequence ID" value="KAK4035299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PC12"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071966">
        <property type="term" value="P:fungal-type cell wall polysaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053183">
        <property type="entry name" value="ASL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024655">
        <property type="entry name" value="Asl1_glyco_hydro_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154">
        <property type="entry name" value="ALKALI-SENSITIVE LINKAGE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154:SF13">
        <property type="entry name" value="ASL1-LIKE GLYCOSYL HYDROLASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11790">
        <property type="entry name" value="Glyco_hydro_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042993599" evidence="2">
        <location>
            <begin position="21"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="Asl1-like glycosyl hydrolase catalytic" evidence="3">
        <location>
            <begin position="181"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="72"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="140"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4035299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="409" mass="43368" checksum="5A8AFD683F61F47E" modified="2024-10-02" version="1">MYTKALAALAAAALVGDAIASPHKHGLQHPHQKRDLVTELVTVTDWVTVTVTEGETTASPKAFYSHSHKSKAQSSSESTTTLTPPAPVVPTTIVTQVTSTSAAPEQNSPPAVEAVPSPSTTSEVVVVNTPPPTPTPPAPSSTAQPASSPAVEDGSGTSGNNNSVDTGNNASADTGASAKRGLAYNNPQLLKSFLSSGTKVSWTYNWGQYDDSGTDLEFCPMLWGLKLDFASTWPANAQKAIDAGSKCLFSFNEPDLGSQANLSPQVAAEKHIELMNPFSGKARIGSPAITNGGGPNMGIQWMQQFFDSCGGKCAVDFVNIHVYGVDTNTFLTHLRNVYAAFNKPVWISEFAFDGSDDQINSQLETVIDQIETNATYSFVERYSYFMVQDGTMLKGNSLSTYGNTFAYGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PDC5</accession>
    <name>A0AAN6PDC5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetylglucosamine-induced protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_49300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854486">
        <property type="protein sequence ID" value="KAK4034281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PDC5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022036">
        <property type="entry name" value="DUF3605"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35020">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-INDUCED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35020:SF4">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-INDUCED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12239">
        <property type="entry name" value="DUF3605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4034281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="220" mass="25788" checksum="1855B993240FEC87" modified="2024-10-02" version="1">MGSTQNLPYWQVNIPEHLRTAECPDFLRSLSDKDRGIISTPDSEYEMDSWPVVREKVAQNRLELFQRVPSDLRRYLGFVWKLKQDYGSVMNFILSQRLQWTLPITPRGRPFELDDDIKVLRNDWPYGIDKRIVHLVVWTKFALEEDAATGDLTDTARAEIDAYVRKAFSKMPPDHVIWFKNWASLKSVKSVEHFHVMLFDPAMEFVNEITNGDVPLCERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PDU0</accession>
    <name>A0AAN6PDU0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cyclin-dependent kinase 1</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Cell division protein kinase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">C8A01DRAFT_48141</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Cyclin-dependent kinase that acts as a master regulator of the mitotic and meiotic cell cycles.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="17">Forms a stable but non-covalent complex with a regulatory subunit (SUC1) and with a cyclin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="MU854436">
        <property type="protein sequence ID" value="KAK4038203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PDU0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010389">
        <property type="term" value="P:regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07835">
        <property type="entry name" value="STKc_CDK1_CdkB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000144">
        <property type="entry name" value="Cyclin-dependent kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000027">
        <property type="entry name" value="Putative Cyclin-dependent kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF254">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 18 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5 21" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="7 18 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 19" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="20">
        <location>
            <begin position="4"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00039266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00041293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00054329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00064036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAK4038203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="324" mass="36533" checksum="7CD56D102790B7BD" modified="2024-10-02" version="1">MENYQKLEKVGEGTYGVVYKARDLNNGGRIVALKKIRLEAEDEGVPSTAIREISLLKEMRDPTIVRLFNIVHADGHKLYLVFEFLDLDLKKYMEALPVSEGGRGKALPEGTGAQLHGLGLGEEMVKKFMSQLCSGVRYCHSHRILHRDLKPQNLLIDREGNLKLADFGLARAFGVPLRTYTHEVVTLWYRAPEILLGGRQYSTGVDMWSVGCIFAEMCTRKPLFPGDSEIDEIFKIFRLLGTPTEDIWPGVTSYPDFKASFPKWARDHTAALCSNLDEAGLDLLEMMLVYDPAGRISAKQACNHPYFENLESHPRAQYHGGSYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PEC8</accession>
    <name>A0AAN6PEC8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ACT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_48570</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854452">
        <property type="protein sequence ID" value="KAK4035183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PEC8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008864">
        <property type="term" value="F:formyltetrahydrofolate deformylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046394">
        <property type="term" value="P:carboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04875">
        <property type="entry name" value="ACT_F4HF-DF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08648">
        <property type="entry name" value="FMT_core_Formyl-FH4-Hydrolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.170">
        <property type="entry name" value="Formyl transferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01927">
        <property type="entry name" value="PurU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041729">
        <property type="entry name" value="Formyl-FH4-Hydrolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004810">
        <property type="entry name" value="PurU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044074">
        <property type="entry name" value="PurU_ACT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004684">
        <property type="entry name" value="PRK06027.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00655">
        <property type="entry name" value="PurU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42706">
        <property type="entry name" value="FORMYLTETRAHYDROFOLATE DEFORMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42706:SF1">
        <property type="entry name" value="FORMYLTETRAHYDROFOLATE DEFORMYLASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036480">
        <property type="entry name" value="FormyFH4_hydr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01575">
        <property type="entry name" value="FFH4HYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="Formyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="3">
        <location>
            <begin position="6"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4035183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="282" mass="31309" checksum="C714638102623E72" modified="2024-10-02" version="1">MANDHILTLSCPDKPGIVHAVTGIFAREGHNILDLQQFSDPTSEKFFMRVHFGPTPTESTEHLRATFDALADEYKMAYEIRPVAQKPRVLIMVSKIGHCLNDLLFRAKTGQLPIEIPVIVSNHPDFAPLAASYGIEFHHLPVTRDTKAAQEGQILDLVKQNNIELVVLARYMQVLSPTLCEAMSGRIINIHHSFLPSFKGAKPYHQAYERGVKIIGATAHFVTADLDEGPIIEQRVARVDHSINPKALVDEGSNIESQVLAAAVKWYAEGRVFLNGTKTVVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PEJ6</accession>
    <name>A0AAN6PEJ6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_16486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854398">
        <property type="protein sequence ID" value="KAK4039519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PEJ6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF102">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE-DEPENDENT METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4039519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="333" mass="37444" checksum="822FCF1709847BF8" modified="2024-10-02" version="1">MAVVKTVLSPTRRCQSLNTIGHAIPYFFAKICGYRSASSASVSSSMYKFVQEHGRTFHKYKEGKYFLPNDEREQNRLDLQHTISKFLLKGKLGLAPVENPGYVLDLGTGTGIWAIEFAEGNPKSEVLGTDLSPIQPDYLPPNCRFEIDDVDDDWAYSHKFDYIHGRYLLPFVNKNWGLLFKSVYDNLNPGGWVEFQETIIYFQSVDGSIEGTALQRWNALLLQGIQKMGRSATEALRCKNYLAEAGFVRLGEKKFAVPMNAWAKGGDQKAIGAMQMANNLEGIDGITMTVFTRALGWKPADVEQLVVDVKRDLKDRNIHAYITVIVAWGQKPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PFG2</accession>
    <name>A0AAN6PFG2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 17">Homoaconitase, mitochondrial</fullName>
            <ecNumber evidence="5 17">4.2.1.36</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16 17">Homoaconitate hydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">C8A01DRAFT_46591</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 17">Catalyzes the reversible hydration of cis-homoaconitate to (2R,3S)-homoisocitrate, a step in the alpha-aminoadipate pathway for lysine biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 17">
            <text>(2R,3S)-homoisocitrate = cis-homoaconitate + H2O</text>
            <dbReference type="Rhea" id="RHEA:15485"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15404"/>
            <dbReference type="ChEBI" id="CHEBI:58174"/>
            <dbReference type="EC" id="4.2.1.36"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="17">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-alpha-aminoadipate from 2-oxoglutarate: step 3/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 17">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.36" evidence="5 17"/>
    <dbReference type="EMBL" id="MU854386">
        <property type="protein sequence ID" value="KAK4040014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PFG2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004409">
        <property type="term" value="F:homoaconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01674">
        <property type="entry name" value="Homoaconitase_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000013">
        <property type="entry name" value="Homoaconitase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004418">
        <property type="entry name" value="Homoaconitase_mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039386">
        <property type="entry name" value="Homoaconitase_swivel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050067">
        <property type="entry name" value="IPM_dehydratase_rel_enz"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00139">
        <property type="entry name" value="h_aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822:SF2">
        <property type="entry name" value="HOMOACONITASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822">
        <property type="entry name" value="HOMOACONITASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 17" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 17" id="KW-0408">Iron</keyword>
    <keyword evidence="11 17" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="14 17" id="KW-0456">Lyase</keyword>
    <keyword evidence="13 17" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="8 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 17" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="18">
        <location>
            <begin position="83"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="19">
        <location>
            <begin position="595"/>
            <end position="716"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00032706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU362038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAK4040014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="792" mass="84659" checksum="DFCB1F64A5F03368" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PFP8</accession>
    <name>A0AAN6PFP8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_16044</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sel-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854385">
        <property type="protein sequence ID" value="KAK4040061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PFP8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050767">
        <property type="entry name" value="Sel1_AlgK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102">
        <property type="entry name" value="SEL-1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102:SF147">
        <property type="entry name" value="SEL1L ADAPTOR SUBUNIT OF ERAD E3 UBIQUITIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043014927" evidence="4">
        <location>
            <begin position="22"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="752"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="780"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="789"/>
            <end position="811"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4040061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="831" mass="91878" checksum="1247DC9842A4003E" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PGB9</accession>
    <name>A0AAN6PGB9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Prion-inhibition and propagation-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_46520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854384">
        <property type="protein sequence ID" value="KAK4040122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PGB9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1020">
        <property type="entry name" value="Prion-inhibition and propagation, HeLo domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029498">
        <property type="entry name" value="HeLo_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038305">
        <property type="entry name" value="HeLo_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37542">
        <property type="entry name" value="HELO DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37542:SF3">
        <property type="entry name" value="PRION-INHIBITION AND PROPAGATION HELO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14479">
        <property type="entry name" value="HeLo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0034">Amyloid</keyword>
    <keyword evidence="2" id="KW-0640">Prion</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prion-inhibition and propagation HeLo" evidence="1">
        <location>
            <begin position="6"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4040122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="282" mass="31201" checksum="39537E1668B10308" modified="2024-10-02" version="1">MAESFGVVSGAVGIATAFKACIDCFEYIKLGRRFGRDFQTSQLALNCTRLRLSRWGEAVHIYDDPYLGRPNATLDELQNAKSTLFQILCLFEDSAAISRKYQLDPKHEGGDELAEFSAGELEPVSASLNNKMRALAIRRQKGASILKTTKWALFDGSEFKRLIENITLLTGNLETMFPAPQQQANLVSYEIQELEDEQQLKLLAGVAQGVDGCLQRAANEALTGHRYQNIQIRGKALNGDAFDQNWRHGAIGAFHTYDGVVVEQGAKAINGNQYGGTSFWDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PGD6</accession>
    <name>A0AAN6PGD6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Adenylate kinase</fullName>
            <ecNumber evidence="6">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP-AMP transphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">ATP:AMP phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Adenylate kinase cytosolic and mitochondrial</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Adenylate monophosphate kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ADK1</name>
        <name evidence="9" type="ORF">C8A01DRAFT_35514</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
            <location evidence="6">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Mitochondrion intermembrane space</location>
        </subcellularLocation>
        <text evidence="6">Predominantly mitochondrial.</text>
    </comment>
    <comment type="domain">
        <text evidence="6">Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the adenylate kinase family. AK2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="6"/>
    <dbReference type="EMBL" id="MU854376">
        <property type="protein sequence ID" value="KAK4040473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PGD6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006172">
        <property type="term" value="P:ADP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046033">
        <property type="term" value="P:AMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046034">
        <property type="term" value="P:ATP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000106">
        <property type="entry name" value="Adenylate kinase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03168">
        <property type="entry name" value="Adenylate_kinase_AK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006259">
        <property type="entry name" value="Adenyl_kin_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007862">
        <property type="entry name" value="Adenylate_kinase_lid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028587">
        <property type="entry name" value="AK2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01351">
        <property type="entry name" value="adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001380">
        <property type="entry name" value="PRK00279.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001381">
        <property type="entry name" value="PRK00279.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011100">
        <property type="entry name" value="PRK14527.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05191">
        <property type="entry name" value="ADK_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Adenylate kinase active site lid" evidence="8">
        <location>
            <begin position="168"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="NMPbind" evidence="6">
        <location>
            <begin position="70"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="6">
        <location>
            <begin position="167"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="50"/>
            <end position="55"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="97"/>
            <end position="99"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="126"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="177"/>
            <end position="178"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4040473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="275" mass="29898" checksum="C3D6A50497DBE2D7" modified="2024-10-02" version="1">MGYLDDEVKRLQGIIANIEGRVQALEGRQLGGGQKKTAEEVRMILIGPPGAGKGTQAPKIKEKFNCCHLATGDMLRSQVAKKTTLGREAKKIMDAGGLVSDDIVIGMIKEELDNNKECKGGFILDGFPRTVPQAEGLDKMLRERNQSLQHAVELKIDDELLVSRITGRLVHPASGRSYHTTFNPPKVNMTDDITGEPLIQRSDDNAEALKKRLATYHKQTAPVVDYYRKTGIWQAIDAAQAPGQVWKSLLAIFDGDKAKAKAAGGGILSKLAPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PGI7</accession>
    <name>A0AAN6PGI7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SET domain-containing protein 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_17396</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854426">
        <property type="protein sequence ID" value="KAK4038549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PGI7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053185">
        <property type="entry name" value="SET_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332:SF6">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="2">
        <location>
            <begin position="204"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4038549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="511" mass="56457" checksum="D6D6F479E1F4B1F6" modified="2024-10-02" version="1">MRPAWFTAASLTTTLPLRPPHLACQALEVYQHSATCPFYSYPFMRAENPTERLKELAVLLSGATGENDGAHQPAKEVHSLDNEPGHTPPSEQRTPPPSRHRKTKEQTPQTRQQERCLSPWSKSPTCRRLHVSTGSNANTNINTNNNAPSDSEFCAFTHASFNNNQGITVITTPDRLRLLSTLPPVTTDNGAAAAAAGGGGDPQPELETIKPYKPIQIPGKGIGLVATKPIRTGTRIMSATPAILVDDRAWKGIRAQEMGVLVAEGVAGLPDKERERVMGLSVKSGWQGGREYGVVAGNAFRVVIDLVGMLGGGEGLEFHGVFTEVSRLNHDCAPNLGYYFDSKTLSLKVYAVRDIFPGEELTISYVDVVQPHSTRQKSLSSAWSFTCTCPRCTLEPHLLGESDSRVKQMQELRRELDDYSGAAMPQTAELLVTLYELEGLQVRIYEAYYRAALEWNGVEDAARAVKYARLCLDKGLLLRGEDRPFVESMREMVRDAKGHWSWRFRVKERGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PHH3</accession>
    <name>A0AAN6PHH3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">26S proteasome regulatory subunit 7 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">C8A01DRAFT_47244</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854405">
        <property type="protein sequence ID" value="KAK4039286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PHH3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000005">
        <property type="entry name" value="26S protease regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000037">
        <property type="entry name" value="26S protease regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000027">
        <property type="entry name" value="26S protease regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048723">
        <property type="entry name" value="OB_PRS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21236">
        <property type="entry name" value="OB_PRS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="12">
        <location>
            <begin position="230"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00067449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK4039286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="455" mass="50607" checksum="99BF1C0E141545F9" modified="2024-10-02" version="1">MVRQPNTLPLDLVAARDPSATGSSWEKYKKNFADDEIEEKKITPLTDEDIQVLKTYGAAPYGASIKKLEQQIKEKQQSVDEKIGVKESDTGLAPPHLWDVAADRQRMSEEQPLQVARCTKIIPDEKDESKSKYVINVKQIAKFVVQLGERVSPTDIEEGMRVGVDRNKYQILLPLPPKIDASVTMMTVEEKPDVTYGDVGGCKEQVEKLREVVEMPLLSPERFGNLGIDPPKGALLYGPPGTGKTLCARAVANRTDATFIRVIGSELVQKYVGEGARMVRELFEMARTKKACIIFFDEIDAIGGARFDDGAGGDNEVQRTMLELITQLDGFDARGNIKVMFATNRPSTLDPALMRPGRIDRKIEFALPDLEGRANILRIHAKSMSVERDIRWELISRLCPNATGAELRSVCTEAGMFAIRARRKVATEKDFLSAVDKVIKGNLKFNSTAAYAQYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PHM8</accession>
    <name>A0AAN6PHM8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Pep3/Vps18/deep orange family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">C8A01DRAFT_34895</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endomembrane system</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854364">
        <property type="protein sequence ID" value="KAK4041051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PHM8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048284">
        <property type="term" value="P:organelle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006904">
        <property type="term" value="P:vesicle docking involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16462">
        <property type="entry name" value="RING-H2_Pep3p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007810">
        <property type="entry name" value="Pep3/Vps18_beta-prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058919">
        <property type="entry name" value="Pep3/Vps18_RING_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323:SF26">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 18 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05131">
        <property type="entry name" value="Pep3_Vps18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26148">
        <property type="entry name" value="VPS18_RING_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101908">
        <property type="entry name" value="Putative isomerase YbhE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Pep3/Vps18 beta-propeller" evidence="9">
        <location>
            <begin position="24"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="639"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="domain" description="Pep3/Vps18 RING C-terminal" evidence="10">
        <location>
            <begin position="874"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="829"/>
            <end position="856"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF26148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK4041051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="982" mass="109019" checksum="B7A98DC2576D2855" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PHT5</accession>
    <name>A0AAN6PHT5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pyridoxal phosphate-dependent transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_45573</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854361">
        <property type="protein sequence ID" value="KAK4041223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PHT5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004015">
        <property type="term" value="F:adenosylmethionine-8-amino-7-oxononanoate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004141">
        <property type="term" value="F:dethiobiotin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03109">
        <property type="entry name" value="DTBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000080">
        <property type="entry name" value="Bifunctional dethiobiotin synthetase/adenosylmethionine-8-amino-7-oxononanoate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00336">
        <property type="entry name" value="BioD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004472">
        <property type="entry name" value="DTB_synth_BioD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42684">
        <property type="entry name" value="ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42684:SF3">
        <property type="entry name" value="ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13500">
        <property type="entry name" value="AAA_26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4041223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="819" mass="89325" checksum="0FA375B8ED6D4E23" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PI60</accession>
    <name>A0AAN6PI60_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NUDIX hydrolase domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_34829</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854363">
        <property type="protein sequence ID" value="KAK4041097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PI60"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047631">
        <property type="term" value="F:ADP-ribose diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006753">
        <property type="term" value="P:nucleoside phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019693">
        <property type="term" value="P:ribose phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18888">
        <property type="entry name" value="NUDIX_ADPRase_Nudt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000016">
        <property type="entry name" value="ADP-sugar pyrophosphatase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839:SF26">
        <property type="entry name" value="ADP-RIBOSE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839">
        <property type="entry name" value="UDP/ADP-SUGAR PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="58"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4041097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="217" mass="23929" checksum="CC7FEA71F90429B7" modified="2024-10-02" version="1">MTTPPKKTQEPLITSITDLPTASAKWITLQKISYLDQTGAPRTWEVASRKTRARSAGVDAVAMGNVLLHPTRPAATVLVIQYRPPLDAYTVEWPAGLIDEGETAEEAAVREFREEIGWECEVVGVSPVQAADPGLSSANMKLVMVEVRLGEGEEEGVLPVQRLEDGEHIQRVVVPLGELYQRLVEYSQKERMVVAAKLFHFAAGMEFARTKGKEYGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PIA7</accession>
    <name>A0AAN6PIA7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_34789</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854362">
        <property type="protein sequence ID" value="KAK4041172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PIA7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042929785" evidence="2">
        <location>
            <begin position="25"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="357"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="177"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4041172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="735" mass="72835" checksum="4D3627AAC1541AF1" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PIK7</accession>
    <name>A0AAN6PIK7_9PEZI</name>
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        <recommendedName>
            <fullName evidence="8">DUF1682 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="6" type="ORF">C8A01DRAFT_16368</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Sordariomycetidae</taxon>
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    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854394">
        <property type="protein sequence ID" value="KAK4039674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PIK7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032469">
        <property type="term" value="P:endoplasmic reticulum calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012879">
        <property type="entry name" value="CCDC47"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12883">
        <property type="entry name" value="ADIPOCYTE-SPECIFIC PROTEIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12883:SF0">
        <property type="entry name" value="PAT COMPLEX SUBUNIT CCDC47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07946">
        <property type="entry name" value="CCDC47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="11"/>
            <end position="53"/>
        </location>
    </feature>
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            <begin position="389"/>
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        <location>
            <begin position="21"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK4039674.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="449" mass="50252" checksum="E01CB544B4142962" modified="2024-10-02" version="1">MASVLNNLFGGKPAASPDSTQAAGDSDFADFSQAADPSPAPVTPESSTSNPFGAAQTVQPYTKWYNVHERHSLSEFKVEGLILSAITVVLLLHLFGARLNRNKAKKWIRAHSAALTSEFSSVGFSGVPVIAADKKGDELLQALADENARQGDNLLKEKSLFEFATYATGRANVAFLDVKLTLLKRFNPFTVLFESVLAFFVDNAAETQDILDAVVYPFDGKEALIVPGIPGAAELRSKDGKSAFDGFVWALVHKERMKQVREDRYDVSLTVTKDHSKLPNWLTVMTESAEITDALLTPELIKAAEMAGDLLEYLIISDQPIEKPKTLNETTPRKRIFLKYRLPSNNDYANLVPLFRYFLRLTDRLVQGARFRPEVLRKVKAAREATAKQIQKADEESKAEERAQERERAKKAKRDLELNALDAKAQKKYLEREREKEMKKSMRKQTTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PIT7</accession>
    <name>A0AAN6PIT7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_34156</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854351">
        <property type="protein sequence ID" value="KAK4041778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PIT7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042885387" evidence="3">
        <location>
            <begin position="21"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="451"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="741"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
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        <location>
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        <location>
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            <end position="69"/>
        </location>
    </feature>
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            <end position="488"/>
        </location>
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        </location>
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        <location>
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            <end position="609"/>
        </location>
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    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="645"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="678"/>
            <end position="716"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4041778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="788" mass="82231" checksum="1B6203DF60ADF5E9" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PJQ1</accession>
    <name>A0AAN6PJQ1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Short-chain dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_34741</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854361">
        <property type="protein sequence ID" value="KAK4041220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PJQ1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43669">
        <property type="entry name" value="5-KETO-D-GLUCONATE 5-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43669:SF3">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G03445)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4041220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="225" mass="24121" checksum="4A82DD4D2D8A6362" modified="2024-10-02" version="1">MASSKTLLVVGSGPGIGRAVTTLFASTRYTNIVLIARRAESLAQEQAAVEAASPLATVKTYGVDITDAAAVSKALDDADAAFGKPECVFYNAARVLPSAFFEHDVQEIEYDFEINVSALYLLAQRYIPHLVALARSANNKPALLVTSSALPLHPIPQLFALSLVKAAQRNLVQSLNLTYAPSGVHVGVINVAGAVSPDEPERNPTNIAAKTWEWFEEGREFEVVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PJT3</accession>
    <name>A0AAN6PJT3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14 15">ATP synthase F(0) complex subunit e, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">C8A01DRAFT_14110</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 15">Subunit e, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro. Part of the complex F(0) domain.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the ATP synthase complex composed at least of ATP5F1A/subunit alpha, ATP5F1B/subunit beta, ATP5MC1/subunit c (homooctomer), MT-ATP6/subunit a, MT-ATP8/subunit 8, ATP5ME/subunit e, ATP5MF/subunit f, ATP5MG/subunit g, ATP5MK/subunit k, ATP5MJ/subunit j, ATP5F1C/subunit gamma, ATP5F1D/subunit delta, ATP5F1E/subunit epsilon, ATP5PF/subunit F6, ATP5PB/subunit b, ATP5PD/subunit d, ATP5PO/subunit OSCP. ATP synthase complex consists of a soluble F(1) head domain (subunits alpha(3) and beta(3)) - the catalytic core - and a membrane F(0) domain - the membrane proton channel (subunits c, a, 8, e, f, g, k and j). These two domains are linked by a central stalk (subunits gamma, delta, and epsilon) rotating inside the F1 region and a stationary peripheral stalk (subunits F6, b, d, and OSCP).</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) and CF(0) have multiple subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the ATPase e subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854344">
        <property type="protein sequence ID" value="KAK4042191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PJT3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008386">
        <property type="entry name" value="ATP_synth_F0_esu_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12427">
        <property type="entry name" value="ATP SYNTHASE E CHAIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12427:SF1">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT E, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05680">
        <property type="entry name" value="ATP-synt_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="11 15" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4 15" id="KW-0138">CF(0)</keyword>
    <keyword evidence="5 15" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8 15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 15" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 15" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="61"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00057306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00064647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00074682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU367005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAK4042191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="94" mass="10376" checksum="20B4DDEA1E11C3D4" modified="2024-10-02" version="1">MSSKSGVNVLRYSALGLGVFYGFYHQRTISSSQKAAAAQREYEHKQELINKAKEAYAKTKQPATSTPAASEVTQDLTSPNFDLEAFVEGLMKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PK26</accession>
    <name>A0AAN6PK26_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">C8A01DRAFT_14858</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="MU854358">
        <property type="protein sequence ID" value="KAK4041400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PK26"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14135">
        <property type="entry name" value="STKc_PRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000078">
        <property type="entry name" value="Serine/threonine-protein kinase PRP4 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044092">
        <property type="entry name" value="STKc_PRP4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF103">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE PRP4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="480"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="350"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="437"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="67"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="178"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="240"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="259"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="294"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="313"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="369"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="509"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK4041400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="810" mass="89792" checksum="F9B595143A47FA2B" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PK70</accession>
    <name>A0AAN6PK70_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_14659</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854354">
        <property type="protein sequence ID" value="KAK4041593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PK70"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4041593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="143" mass="14896" checksum="F6EFB5DF29D1BFDF" modified="2024-10-02" version="1" fragment="single">SAEIGPRLPFGQETSLSTWPEIGFEHADMPSDLSGGRQAHCLAVHGTGDITVDPQYLTFGPDALGLDFSGQVLGVGLPPLFPEGVPDSCYHGETGFYGTELGYPVNVSATYPAQSPCYPTGDSIPGAPVFSVAFPPVSHASDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PK99</accession>
    <name>A0AAN6PK99_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Granulins domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_13952</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854341">
        <property type="protein sequence ID" value="KAK4042446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PK99"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043033389" description="Granulins domain-containing protein" evidence="2">
        <location>
            <begin position="26"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4042446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="157" mass="16486" checksum="8596392333C1E94C" modified="2024-10-02" version="1">MHHHQWVLAVASCLAVFGSSSSALAAAVPAPGGGGAGGGEQQKPLGRLPPMSGGVTRQYMSCEETYGNLWTTCGGGRQNSRSCYSPALGQSCCLVDNNYCDKGTWCAPVVGYCCLDSEDLETCARNAGFELPDIETLRDLASAGARESMSSRTWPEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PKB3</accession>
    <name>A0AAN6PKB3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein uS13m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_34271</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the universal ribosomal protein uS13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854353">
        <property type="protein sequence ID" value="KAK4041668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PKB3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.910.10:FF:000004">
        <property type="entry name" value="Small subunit ribosomal protein S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.910.10">
        <property type="entry name" value="30s ribosomal protein s13, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027437">
        <property type="entry name" value="Rbsml_uS13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001892">
        <property type="entry name" value="Ribosomal_uS13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_uS13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018269">
        <property type="entry name" value="Ribosomal_uS13_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S13/40S RIBOSOMAL PROTEIN S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US13M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00416">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002134">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="S13-like H2TH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00646">
        <property type="entry name" value="RIBOSOMAL_S13_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RIBOSOMAL_S13_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4041668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="119" mass="13485" checksum="B739F5B0C05FFD59" modified="2024-10-02" version="1">MVAIFGVNFNEQKLVKKALESFYALGPQTSARILAKYYIHPRAKVGTLAPKTVTALTAELSTMTIESDARRALQDNIKRLRDMGTYRGRRHAMGLPVRGQRTRNQIETAKKLNRVERRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PKH7</accession>
    <name>A0AAN6PKH7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_44293</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854337">
        <property type="protein sequence ID" value="KAK4042669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PKH7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="13"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="72"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="275"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="499"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="286"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="310"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="337"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="366"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="386"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4042669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="586" mass="62154" checksum="58BB4330A25FB36D" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PKK2</accession>
    <name>A0AAN6PKK2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_35782</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854382">
        <property type="protein sequence ID" value="KAK4040180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PKK2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08760">
        <property type="entry name" value="Cyt_b561_FRRS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018825">
        <property type="entry name" value="DUF2427"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018827">
        <property type="entry name" value="YTP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31685">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_6G12730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31685:SF2">
        <property type="entry name" value="PROTEIN YTP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10348">
        <property type="entry name" value="DUF2427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10355">
        <property type="entry name" value="Ytp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="139"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="168"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="261"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2427" evidence="3">
        <location>
            <begin position="12"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Protein YTP1-like C-terminal" evidence="4">
        <location>
            <begin position="141"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4040180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="459" mass="50999" checksum="4F38D334369506F5" modified="2024-10-02" version="1">MALGHGGHHTDKIPEGQTISLEPIDTTLWIHIFVQMLAFGILFPIGMVLGIVKSRWHVPLQIFSTALALLGYALGHLHRGRQFNPKNVHAMAATPLFFLMVAQVVFGVYLKLHLEKGIHGRIRPFFRIAHSINGKAFPVYAWVQMIFGGITALGFCQGDHLGQCLAHFIMGGAFIAYGVLLTILLLVGQLWLRRTGRSQEFFDSAVIAAWGCVNTFTEHRWGTAWVRNDWQHTTMGIIWWSAGLVGVWLSRDRHGAPKRNFIPGFVILITGWGMSAHPQELMISAMTHQMFGYTLMAAGLTRIIEVSFILRDKPGISEDGTEANSFQFIPVFLLYAAGFLFMGATEEQMQLLAGSGIDHVAYVMILYSLASLLFLFTMAVIHVYDRANPIAKKPLANGRAVRGDDAQLRDANEFELDGLVSDDEDEERAARRKLLRDDGLEEDGPSSPSTVGRNSDRVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PKR0</accession>
    <name>A0AAN6PKR0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Alpha-L-arabinofuranosidase</fullName>
            <ecNumber evidence="11">3.2.1.55</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">C8A01DRAFT_45106</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Alpha-L-arabinofuranosidase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides.</text>
            <dbReference type="EC" id="3.2.1.55"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the glycosyl hydrolase 62 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.55" evidence="11"/>
    <dbReference type="EMBL" id="MU854351">
        <property type="protein sequence ID" value="KAK4041775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PKR0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046373">
        <property type="term" value="P:L-arabinose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08987">
        <property type="entry name" value="GH62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005193">
        <property type="entry name" value="GH62_arabinosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40631">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE AXHA-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40631:SF1">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE AXHA-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03664">
        <property type="entry name" value="Glyco_hydro_62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 11 12" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043044157" description="Alpha-L-arabinofuranosidase" evidence="12">
        <location>
            <begin position="19"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK4041775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="321" mass="35059" checksum="725277AE53BB0A25" modified="2024-10-02" version="1">MKLSQITTLLASAAGVTAFCDLPSRYRWTSTGPLADPQHGWVSLKDFTVVPYNGQHLVYGTQFSTGGGWGSMNFGLISNWNDLGRASQNKMDGAAVAPTLFYFAPKRVWVLAHQWGPQPFSYRTSNDPTNANSWSAPQTLFTGSISDSRTNVIDQTLIGDDTTMYLFFAGDNGKIYRATMPLGNFPGSFGSNYQTIMTDTLANLFESVQVYKLQGQTKYLMIVEAIGANGARYFRSFTATNLGGQWTTQAATEGNPFAGKANAGAGWTNDISHGDLIRVTNDQTMTVDPCNLQMLYQGRTPGPDGDYGLLPYRPAVLTLQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PKR9</accession>
    <name>A0AAN6PKR9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_14512</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854351">
        <property type="protein sequence ID" value="KAK4041790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PKR9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4041790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="260" mass="28819" checksum="9103427F35F97B31" modified="2024-10-02" version="1">MPRSVHFILPGRERRASERPATCIVSNGVLNVCGRAAAEGRDCPEPVCADHLCQYRRSNGHSCKRTPLRLAHGDVYTTGGWFPDTEQSVNCARHERYNCVALINGAARCPGMKTHGRDYCSAHAATPCKWKSRDGSLDITDHDGYRCPKRRSPSTVFCRGHRCVWKSDKHIQCHGISYPNTVGGVCTDHICMKGNCGNGALNGADRCSEHVCAFQPPGQQPADFPVCGSEPVEGQPFCETHDQLVRWCAQMMEGQNRWLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PKZ0</accession>
    <name>A0AAN6PKZ0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_13808</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854338">
        <property type="protein sequence ID" value="KAK4042642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PKZ0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16536">
        <property type="entry name" value="RING-HC_RNF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039739">
        <property type="entry name" value="MAG2/RNF10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12983:SF9">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12983">
        <property type="entry name" value="RING FINGER 10 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="188"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="550"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="625"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="479"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="29"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="562"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="629"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4042642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="662" mass="72878" checksum="7DD5B5C53508C2F0" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PL84</accession>
    <name>A0AAN6PL84_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_44055</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854333">
        <property type="protein sequence ID" value="KAK4042986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PL84"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF12">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G06440)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="365"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="396"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="440"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="475"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="506"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="540"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="136"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="64"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="616"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="573"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="37"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="80"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="616"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4042986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="635" mass="68996" checksum="FFD779C1C105FD17" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PLE1</accession>
    <name>A0AAN6PLE1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CBS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_13507</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'-AMP-activated protein kinase gamma subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854334">
        <property type="protein sequence ID" value="KAK4042932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PLE1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031588">
        <property type="term" value="C:nucleotide-activated protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04618">
        <property type="entry name" value="CBS_euAMPK_gamma-like_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04641">
        <property type="entry name" value="CBS_euAMPK_gamma-like_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050511">
        <property type="entry name" value="AMPK_gamma/SDS23_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780">
        <property type="entry name" value="AMP-ACTIVATED PROTEIN KINASE, GAMMA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780:SF35">
        <property type="entry name" value="LD22662P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0129">CBS domain</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CBS" evidence="6">
        <location>
            <begin position="178"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="6">
        <location>
            <begin position="254"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="6">
        <location>
            <begin position="328"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="8"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4042932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="391" mass="43532" checksum="0A21FA07BD3F8693" modified="2024-10-02" version="1">MDDPRVPPEAAHPSSRSAPPAYAPTTTAAGGETGSGQLPLRPGHELPFVAPSSYLRPNPSRTMSERTPSALDKEQMQGLRGIREFLKVRTSYDVLPLSFRLVVLDNELLIRKSLNILIQNGIVSAPLWDSSNSTFAGLLTSTDYINVIQYYCQFPDEIDQVDKFRLSSLRDIERAIGVLPLETVSVHPMRPLYEACRRMLKTRARRIPLVDVDDETGREMVVSVITQYRILKFIAVNNEKHTILLKKSVRELGLGTYSNLATADMNSSVLDVIHLMVKHNISAVPIIDKGNKVLNVFEAVDVIPCIKGGAYDELASSVGEALSKRADDFPGIYTCNEDDRLDAIFETIRKSRVHRLIVVDDNNQLRGIISLSDILKHVLLFGEEEDNIRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PLH8</accession>
    <name>A0AAN6PLH8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-(apurinic or apyrimidinic site) endonuclease 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">C8A01DRAFT_15459</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="11">Probably binds two magnesium or manganese ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA repair enzymes AP/ExoA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854371">
        <property type="protein sequence ID" value="KAK4040705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:base-excision repair"/>
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        <property type="entry name" value="Ape2-like_AP-endo"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DNA-(apurinic or apyrimidinic site) lyase"/>
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    </dbReference>
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        <property type="entry name" value="AP_endonuc_1"/>
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    <dbReference type="InterPro" id="IPR020847">
        <property type="entry name" value="AP_endonuclease_F1_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020848">
        <property type="entry name" value="AP_endonuclease_F1_CS"/>
    </dbReference>
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        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
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        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
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        <property type="entry name" value="Znf_GRF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748">
        <property type="entry name" value="AP ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748:SF4">
        <property type="entry name" value="DNA-(APURINIC OR APYRIMIDINIC SITE) ENDONUCLEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AP_NUCLEASE_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AP_NUCLEASE_F1_3"/>
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    </dbReference>
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        <property type="entry name" value="AP_NUCLEASE_F1_4"/>
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    </dbReference>
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        <property type="entry name" value="ZF_GRF"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GRF-type" evidence="15">
        <location>
            <begin position="591"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="386"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="386"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="397"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="426"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="483"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="504"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="541"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="10">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="313"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
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    <feature type="binding site" evidence="11">
        <location>
            <position position="197"/>
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        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
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    <feature type="binding site" evidence="11">
        <location>
            <position position="312"/>
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        <ligand>
            <name>Mg(2+)</name>
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            <position position="313"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
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    <feature type="site" description="Transition state stabilizer" evidence="12">
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            <position position="197"/>
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    <feature type="site" description="Important for catalytic activity" evidence="12">
        <location>
            <position position="287"/>
        </location>
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    <feature type="site" description="Interaction with DNA substrate" evidence="12">
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            <position position="313"/>
        </location>
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            <dbReference type="ARBA" id="ARBA00001936"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00007092"/>
        </source>
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        <source>
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            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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            <dbReference type="ARBA" id="ARBA00022842"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
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        <source>
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        </source>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01343"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51999"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK4040705.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="647" mass="71171" checksum="9155DCE1A1C9CD0B" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PLK7</accession>
    <name>A0AAN6PLK7_9PEZI</name>
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        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_14080</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854343">
        <property type="protein sequence ID" value="KAK4042285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cell periphery"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
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        <property type="entry name" value="AXIAL BUDDING PATTERN PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="253"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
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            <end position="250"/>
        </location>
    </feature>
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        <location>
            <begin position="333"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="203"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="217"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4042285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="357" mass="36406" checksum="7F01ED512FDA9430" modified="2024-10-02" version="1">MEAYTGRAGAALGPLTTTWSGMPASCTVHALICPTCSTAFQGQKCSRDDVNGEQIITDNSACWPPATPGAGTPPRPLAGWGYYSPGLACPSGYSTACTAQHGGRSEWDVEFNLVAGETAIGCCPEGFHCTNLKGNTCMAFADTGSPTVVAAGTCSGSVMLSAQATFPDLVTLTGTLDVLTRRMTLLAPMFQLNHQATDLPAGPSTTAIVASETSPASPSGATGGPTHTTSSPSTSTSAPASADSQGGGLSTGAAAGVGVGATLGAVLLVAAVAAWAWRRKRRQRAAVAGPEAVGMVPENATWETWKPPPSNYSPSAPTELHAGYHGAEMYTSYPPAELPESLRTAHPSHMSDSPTYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PLL2</accession>
    <name>A0AAN6PLL2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ser thr protein phosphatase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_45678</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854363">
        <property type="protein sequence ID" value="KAK4041146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PLL2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37844">
        <property type="entry name" value="SER/THR PROTEIN PHOSPHATASE SUPERFAMILY (AFU_ORTHOLOGUE AFUA_1G14840)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37844:SF2">
        <property type="entry name" value="SER_THR PROTEIN PHOSPHATASE SUPERFAMILY (AFU_ORTHOLOGUE AFUA_1G14840)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="1">
        <location>
            <begin position="18"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4041146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="451" mass="50197" checksum="D160024F21329A9C" modified="2024-10-02" version="1">MEALFNKVRQRLGPRPRVQILSDLHLEVGQQYSTFTFPATAPFLLLAGDIGRLIDYTAYCGFLESQVARYKQVFLVLGNHEFYGLDYESGLAEARRLAQEPSLRNGLMLLNCARWDDPDSDLIILGCTLWSAIPQDAYGVVEAKVNDFKKINQWTAKQHNTIHLKELSWIRENVRLITAAPGKKRLLIATHHAPCIEGTSRPEHVSNPWTPAFATDLVDQHGWEVTMLHQRLNDAAIALHRVLDHENINIGIFGGYAVTAIGGVRESKDVECLASVSKDQIIQILNGKEGFAVIPQSRTDYVTFLWSNNPGRQNAVLVEMFCERFPGAQFSMAGVPCNTVAIQGLTLGQGTSRFLDPFYIFKGKLRAAATPSKFTDSADLRMLVSRHEAIIRPRVGELSIEYLGHAVKRYIELGILFERLGIDVEAAKEAVKDVDQLPPPAPGDVQQGLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PMF6</accession>
    <name>A0AAN6PMF6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_43417</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854325">
        <property type="protein sequence ID" value="KAK4043661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PMF6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="97"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="133"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="389"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="150"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="221"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="268"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="309"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="396"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4043661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="412" mass="44156" checksum="609DBDB5C34E0CCB" modified="2024-10-02" version="1">MTDIMSYQYPPPPNGADMDMPQSGYLPGYSSSGMDPDSSIPSRERSELRRSISTPVVGPSQGHPQQPTTPQQPGAPGLDAAAERRRNKLGYHRTSVACGHCRRRKIRCVPSQNDVQGRCINCIRLKKECSFYPVDQQPPVDTRQKSGSRSSVGPKPPSASSSPAMQPGIPSDIHGQQPYPHLAMPSIQNMAPPMKPSGSDTHPSDSKMPSSTRGYEYGQHGMSNWMSADTSPSSSKPSDMNATWRSYPGDSPVTPAFSPYTPHAPPSATWSASVGSESSSRDDIAWSSYPAPPPRSLSFGAESMAGHQQYPSISQISSHSGRGYDRKSSSVSADMYPPPIATTIPGIETVPGTTLDQNVSLSAGAVPPSSYASWQQSYSYSKPEGYGGWYGEAGDQHSSGHGHPSSNVYYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PMV6</accession>
    <name>A0AAN6PMV6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alkyl transferase</fullName>
            <ecNumber evidence="3">2.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_14293</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the UPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="3"/>
    <dbReference type="EMBL" id="MU854347">
        <property type="protein sequence ID" value="KAK4042044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PMV6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904423">
        <property type="term" value="C:dehydrodolichyl diphosphate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045547">
        <property type="term" value="F:ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016094">
        <property type="term" value="P:polyprenol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00475">
        <property type="entry name" value="Cis_IPPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="entry name" value="Decaprenyl diphosphate synthase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01139">
        <property type="entry name" value="ISPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001441">
        <property type="entry name" value="UPP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018520">
        <property type="entry name" value="UPP_synth-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00055">
        <property type="entry name" value="uppS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291:SF43">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE COMPLEX SUBUNIT DHDDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01255">
        <property type="entry name" value="Prenyltransf"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="Undecaprenyl diphosphate synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01066">
        <property type="entry name" value="UPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="214"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="218"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU363018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4042044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="358" mass="40664" checksum="B8837C09E9AE16B0" modified="2024-10-02" version="1">MSDLYLSRIRSWFMSSPPAEWALNRLRSTLIGALSQGPIPRHVAFEMDGNRRFARSHKIETIEGHHLGFEALARVLEVCYKCGVKVVTVYAFSLENFHRPKYEVDGLMQLAKLKLEQLAQHGELLDRYGASVRVLGRLDLIPPDVLEVVERAAAATQHNTDCVLNICFPYGSREEMTTAIRTTVEEYSTTPRPHSTPFSQNRITQKILSKQAGKPDLLEPISESPSPTPSSIQSDDQDDVVSTATTLHSDSTAIKSGGDEETAVAIYPNAETITPETIDRHLYTAGCPPLDIFVRTSGVERLSDYLLWQCHQDTHIFFLKCFWPEFDLWSFLPVLVEWQWRQKQKARDERPPRRVKQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PN08</accession>
    <name>A0AAN6PN08_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_31921</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854322">
        <property type="protein sequence ID" value="KAK4044049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PN08"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05374">
        <property type="entry name" value="17beta-HSD-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051911">
        <property type="entry name" value="SDR_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976:SF16">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="318"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="328"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="338"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4044049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="381" mass="41800" checksum="6AEDEE5604CA1A16" modified="2024-10-02" version="1">MDTRSVHDGSSVAGSDAPRMKLQLPASCDPPQPGAPVKPLVWIVFGGTGHMGRSLVKSALGHGDLVTTVGRVIETAPDAIATLNSDTCLGQLCDVRDGASVARVIERTLDRFGRIDCIANCSGYGVIGACEDQDEHELRNQFETNFMGTLHIVQASLPYFRQQNGGRYLIFSSTSGALGVPGLGPYCATKYAVEGLIEAMLYEVDSFNIKATLVEPGLVRRDEPDSKMNPLPTWGHFLIKPASDAYSHATSPALHAKRMVQWLGDRQPTSAVKCAELVWQLGHCSYPPLRLLLGSYAIESIRDRLRSVTEELEDWKHLNYPVPPDASGGERGEKTDREEGDERGEGEERDEMEEREGDEDREREDDLMEGITPDAKDTENT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PNM8</accession>
    <name>A0AAN6PNM8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GPI inositol-deacylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_43694</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854328">
        <property type="protein sequence ID" value="KAK4043380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF16">
        <property type="entry name" value="GPI INOSITOL-DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="5">
        <location>
            <begin position="277"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase winged helix" evidence="4">
        <location>
            <begin position="515"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="2">
        <location>
            <begin position="1125"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="904"/>
            <end position="931"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4043380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1478" mass="164830" checksum="ED107D8D9E915D21" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PNS9</accession>
    <name>A0AAN6PNS9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HAD-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_44532</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854340">
        <property type="protein sequence ID" value="KAK4042524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PNS9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046474">
        <property type="term" value="P:glycerophospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050324">
        <property type="entry name" value="CDP-alcohol_PTase-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006353">
        <property type="entry name" value="HAD-SF_hydro_IIA_CECR5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01456">
        <property type="entry name" value="CECR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269:SF57">
        <property type="entry name" value="SUPERFAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13242">
        <property type="entry name" value="Hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4042524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="468" mass="50906" checksum="83A983D065A025A2" modified="2024-10-02" version="1">MGFGLHGISSEAACIWSAYALLFLGILLFFLRAPAKFRSRPIAQSTRGLDASPSAGTADVGRPGSLSFFPGLHQSPASDSDVSVGSSGLEPPPFAFAFDIDGVLLHVAKPIPGATAVLRFLNDYNIPFILLTNGGGKHETERVRDLGERLGVPLSTDNFVQSHTPFQELLEGPDSLRDKTVLVTGSDYEKCRAIFKEYGFQNVITPADIYAASPTIFPFQPASTFTTPTAPLPKPLYTSPTLSSSTLPSHLKVDAIFILNDPRDWALDTQIITDLLLSHAGHVGTYSPLNNSPTLPNNGWQRDGQPRLYFSNADLLWSAGYHLPRLGQGAFQAALAGLWRRITGGSAELERTSIGKPYGETYRFAERVLAGHRGEVLRVMGNDKKVGALRRVYMVGDNPESDIAGANGYVSAEGTEWVSVLVRTGVWSEERGRKLEGEFEPRVVVDDVMGAVKWAFRREGWVGGEELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PNU4</accession>
    <name>A0AAN6PNU4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glutamate carboxypeptidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_42668</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M28 family. M28B subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854318">
        <property type="protein sequence ID" value="KAK4044484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PNU4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08022">
        <property type="entry name" value="M28_PSMA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02121">
        <property type="entry name" value="PA_GCPII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.30:FF:000008">
        <property type="entry name" value="Glutamate carboxypeptidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000101">
        <property type="entry name" value="N-acetylated alpha-linked acidic dipeptidase like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.40">
        <property type="entry name" value="Transferrin receptor-like, dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039373">
        <property type="entry name" value="Peptidase_M28B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007365">
        <property type="entry name" value="TFR-like_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036757">
        <property type="entry name" value="TFR-like_dimer_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404">
        <property type="entry name" value="N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404:SF46">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04253">
        <property type="entry name" value="TFR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47672">
        <property type="entry name" value="Transferrin receptor-like dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="5">
        <location>
            <begin position="197"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="7">
        <location>
            <begin position="391"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="domain" description="Transferrin receptor-like dimerisation" evidence="6">
        <location>
            <begin position="689"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="255"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="683"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="279"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4044484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="814" mass="90844" checksum="8A64179E92F110EA" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PP79</accession>
    <name>A0AAN6PP79_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Abscisic acid G-protein coupled receptor-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_42598</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854317">
        <property type="protein sequence ID" value="KAK4044694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PP79"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025969">
        <property type="entry name" value="ABA_GPCR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022535">
        <property type="entry name" value="Golgi_pH-regulator_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015672">
        <property type="entry name" value="GPHR/GTG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15948">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 89-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15948:SF0">
        <property type="entry name" value="GOLGI PH REGULATOR A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12430">
        <property type="entry name" value="ABA_GPCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12537">
        <property type="entry name" value="GPHR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="289"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="505"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="541"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="Golgi pH regulator conserved" evidence="8">
        <location>
            <begin position="281"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="Abscisic acid G-protein coupled receptor-like" evidence="7">
        <location>
            <begin position="433"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4044694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="634" mass="66255" checksum="876DC7B4F6EA4CF4" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PPA7</accession>
    <name>A0AAN6PPA7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator TACO1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_11916</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TACO1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854317">
        <property type="protein sequence ID" value="KAK4044718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PPA7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.200:FF:000002">
        <property type="entry name" value="Probable transcriptional regulatory protein CLM62_37755"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00693">
        <property type="entry name" value="Transcrip_reg_TACO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017856">
        <property type="entry name" value="Integrase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048300">
        <property type="entry name" value="TACO1_YebC-like_2nd/3rd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049083">
        <property type="entry name" value="TACO1_YebC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002876">
        <property type="entry name" value="Transcrip_reg_TACO1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026564">
        <property type="entry name" value="Transcrip_reg_TACO1-like_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029072">
        <property type="entry name" value="YebC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12532">
        <property type="entry name" value="TRANSLATIONAL ACTIVATOR OF CYTOCHROME C OXIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12532:SF0">
        <property type="entry name" value="TRANSLATIONAL ACTIVATOR OF CYTOCHROME C OXIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20772">
        <property type="entry name" value="TACO1_YebC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01709">
        <property type="entry name" value="Transcrip_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75625">
        <property type="entry name" value="YebC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TACO1/YebC-like N-terminal" evidence="4">
        <location>
            <begin position="39"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="TACO1/YebC-like second and third" evidence="3">
        <location>
            <begin position="118"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4044718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="295" mass="32118" checksum="E5E3C41A88FA995C" modified="2024-10-02" version="1">MASLFRPLAPLTRPATPSSICAQCRRAFVSSPVLQSGHNKWSKIRHDKAANDAKKNMARTIFAKNITLYSKLYGPDPNHNPQLATAIHAAKKASVPKDKIEGAIARGQGRSSAGTALDSLTFEAVMPPSIALIVDVETESKLRALQELNQMVKKAKGSSSSSRFFFSRLGRVVFEKGESGLDVDQIMDEAIEAGAEDLENDAEGNIVVWTQPSGTMQVCKAVGSKFGLKILSSDIIWAANEDTKTKLDASEELVNFTELLEALREYPEVQAVYSNVSKGAMSDEEWAKIEDNLDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PPC8</accession>
    <name>A0AAN6PPC8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_12721</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854324">
        <property type="protein sequence ID" value="KAK4043770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PPC8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4043770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="239" mass="26938" checksum="046F9349001654BB" modified="2024-10-02" version="1">MFQRTLRRLKPPQLPDGFSTNFETGTFRLPHTTGQHAAHPTTMSQDFNPSKKVLKFASDHRIAFPTAINLVPGQRVKDFHIRMHLCPHHTFSFYHLKYLAEFEHPLITKILHFYTQEKQTKPLWCYVQGSSTADGSKVVVRCASERMVRAALFRALNAAGYDSIGKSLDGSKPDLRGTIRIAIPWPKAALKVEFDPLVEYLTGLVADAVPRLDGSSPLPWRQARGPRGSWNGSTTKVFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PPJ6</accession>
    <name>A0AAN6PPJ6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Plectin/S10 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_44654</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein eS10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854343">
        <property type="protein sequence ID" value="KAK4042265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PPJ6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000025">
        <property type="entry name" value="40S ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005326">
        <property type="entry name" value="Plectin_eS10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037447">
        <property type="entry name" value="Ribosomal_eS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12146">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12146:SF0">
        <property type="entry name" value="RIBOSOMAL PROTEIN S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03501">
        <property type="entry name" value="S10_plectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Plectin/eS10 N-terminal" evidence="7">
        <location>
            <begin position="3"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="90"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="103"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4042265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="167" mass="18732" checksum="FE31D19087494F64" modified="2024-10-02" version="1">MLIPKADRKAIHEYLFREGVMVAAKNYETTHETGIRNLFVIKACQSLTSRGYVKTQFSWQYYYYTLTPEGLDYLREWLHLPAEIVPATHIKQQRSHAPPRGMLGEERGERRFGGGRGRGGDRGDREGGYRRRDAGEGKEGGAPSDFAPQFRGGFGRGRGGRGDAPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PQ17</accession>
    <name>A0AAN6PQ17_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Endopeptidase Clp</fullName>
            <ecNumber evidence="22">3.4.21.92</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">C8A01DRAFT_42502</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>(2R)-2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:24809"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:49072"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:24810"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>(2R,3R)-2,3-dihydroxy-3-methylpentanoate = (S)-3-methyl-2-oxopentanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:27694"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:49258"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:27695"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18 22">
            <text>Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec, and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs).</text>
            <dbReference type="EC" id="3.4.21.92"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="19">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="17">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="16">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 3/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IlvD/Edd family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase S14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.92" evidence="22"/>
    <dbReference type="EMBL" id="MU854316">
        <property type="protein sequence ID" value="KAK4044897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PQ17"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:ATP-dependent peptidase activity"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:serine-type endopeptidase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07017">
        <property type="entry name" value="S14_ClpP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATP-dependent Clp protease proteolytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.80:FF:000001">
        <property type="entry name" value="Dihydroxy-acid dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="IlvD/EDD C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ClpP"/>
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        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
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        <property type="entry name" value="ClpP_His_AS"/>
    </dbReference>
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        <property type="entry name" value="ClpP_Ser_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050165">
        <property type="entry name" value="DHAD_IlvD/Edd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042096">
        <property type="entry name" value="Dihydro-acid_dehy_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004404">
        <property type="entry name" value="DihydroxyA_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020558">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056740">
        <property type="entry name" value="ILV_EDD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000581">
        <property type="entry name" value="ILV_EDD_N"/>
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    <dbReference type="InterPro" id="IPR037237">
        <property type="entry name" value="IlvD/EDD_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00110">
        <property type="entry name" value="ilvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001368">
        <property type="entry name" value="PRK00277.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002068">
        <property type="entry name" value="PRK00911.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21000">
        <property type="entry name" value="DIHYDROXY-ACID DEHYDRATASE DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21000:SF5">
        <property type="entry name" value="DIHYDROXY-ACID DEHYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24877">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ILVD_EDD_N"/>
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    </dbReference>
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        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143975">
        <property type="entry name" value="IlvD/EDD N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00382">
        <property type="entry name" value="CLP_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00381">
        <property type="entry name" value="CLP_PROTEASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00886">
        <property type="entry name" value="ILVD_EDD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00887">
        <property type="entry name" value="ILVD_EDD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="14" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="13" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase N-terminal" evidence="23">
        <location>
            <begin position="250"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase C-terminal" evidence="24">
        <location>
            <begin position="581"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="active site" evidence="21">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="active site" evidence="22">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00029436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00029437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00034021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00052865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF00920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF24877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="KAK4044897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="775" mass="83201" checksum="E31575F6791CFB15" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PQJ0</accession>
    <name>A0AAN6PQJ0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_31745</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
    <dbReference type="EMBL" id="MU854321">
        <property type="protein sequence ID" value="KAK4044143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PQJ0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000060">
        <property type="entry name" value="Ubiquitin conjugating enzyme (UbcB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="7">
        <location>
            <begin position="3"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="168"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="181"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4044143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="198" mass="20813" checksum="A5D5CB119175E51C" modified="2024-10-02" version="1">MASQNKRIAKELAECTSSPPPGITVTLPNDSDLHKWHVTLDGPENSVYAGGRFGLVVSLPADYPFRAPTVTFATRIYHPNVTNDQLGNICLGPLKAENWKPSTRLAGVLEAVRALLAEPQPDDPLEARIADEFRAERQEFDKNARSYVQRYAKGPVKFDVAAVGAAAAGEGGEDKKGAGGAATAAGASRSGGNTASGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PR02</accession>
    <name>A0AAN6PR02_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Conidiation-specific protein 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_43433</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854325">
        <property type="protein sequence ID" value="KAK4043679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PR02"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4043679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="95" mass="10134" checksum="C3BEE0280B609BC3" modified="2024-10-02" version="1">MADNIPSGTEFRAGRADSTSSSTSTGTSNSNSTSSGGGAPAQPHRRPSHPLFEGLQAQKRSSDPASVARRQSMNEQRPTTGFIGQMWNNWVRGNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PRC7</accession>
    <name>A0AAN6PRC7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tetratricopeptide repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_31021</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854316">
        <property type="protein sequence ID" value="KAK4044835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PRC7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4044835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="99" mass="11367" checksum="0830E16C0D1B00DC" modified="2024-10-02" version="1">MVIERRQDRSNLSHSHSLAGVLLETGRYEEAEREETAVRDWLDGRLGRESPQALGARRVVAEAVWRQGRREEGERLMREVEGIVEGTGEDSPYAVYRDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PRR6</accession>
    <name>A0AAN6PRR6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CobW/HypB/UreG, nucleotide-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_42392</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854316">
        <property type="protein sequence ID" value="KAK4044773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PRR6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03112">
        <property type="entry name" value="CobW-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051316">
        <property type="entry name" value="Zinc-reg_GTPase_activator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13748:SF62">
        <property type="entry name" value="COBW DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13748">
        <property type="entry name" value="COBW-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CobW/HypB/UreG nucleotide-binding" evidence="1">
        <location>
            <begin position="15"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4044773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="387" mass="41627" checksum="63EE11AC988777B0" modified="2024-10-02" version="1">MTQPDPPTTRNKPIPITIVTGFLGAGKTTLILNLLPQLRALNPSYKLALLKNEFGDLAIDSQLASSSAIAGVTELLNGCICCNLVGQLGPALAELRATATPDRVVVETSGSAFPATLALEVNRLARETSGEYVLDGVVSVIDVENWKGYEDTSYTARLQARYTDLVVFNKWEGCGERRFDEVLDRLGDLEVDVAWVKSDKGWVDAGVVFGVDGGLARGMVEEGGDVTAAGEGCKHGDGCGHEHEHGKEHHQSEVEVLSVELKGEEGAAVDVEKLMGFLKSTPKDEVYRIKAVLTAAGAVKNSDEDVAVLASPQSTNRYILNWAFGRWTFTPMGDGVAEHASSNDAILRMTVILARYESTKWKKRLEAGGRLELDGADKGQLTVAKVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PSE5</accession>
    <name>A0AAN6PSE5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rab-GTPase-TBC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_31912</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854322">
        <property type="protein sequence ID" value="KAK4044041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PSE5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000038">
        <property type="entry name" value="TBC1 domain family member 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000031">
        <property type="entry name" value="TBC1 domain family member 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF337">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="3">
        <location>
            <begin position="36"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="587"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="702"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="587"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="607"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="621"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="647"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="671"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="702"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="720"/>
            <end position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4044041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="782" mass="85746" checksum="D5570EA2557C453B" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PT32</accession>
    <name>A0AAN6PT32_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Calmodulin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_31003</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the calmodulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854316">
        <property type="protein sequence ID" value="KAK4044819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PT32"/>
    <dbReference type="SMR" id="A0AAN6PT32"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000058">
        <property type="entry name" value="Calmodulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000257">
        <property type="entry name" value="Calmodulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000027">
        <property type="entry name" value="Calmodulin (CaM)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM01184">
        <property type="entry name" value="efhand_Ca_insen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="8"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="44"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="81"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="117"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4044819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="149" mass="16997" checksum="391C14BA2C533A89" modified="2024-10-02" version="1">MADSLTEEQVSEFKEAFSLFDKDGDGQITTKELGTVMRSLGQNPSESELQDMINEVDADNNGTIDFPEFLTMMARKMKDTDSEEEIREAFKVFDRDNNGFISAAELRHVMTSIGEKLTDDEVDEMIREADQDGDGRIDYNEFVQLMMQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PTD4</accession>
    <name>A0AAN6PTD4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WH2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_31290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854318">
        <property type="protein sequence ID" value="KAK4044506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PTD4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003124">
        <property type="entry name" value="WH2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02205">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51082">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WH2" evidence="2">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="205"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="328"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4044506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="427" mass="41780" checksum="6C25D7D642BE4532" modified="2024-10-02" version="1">MPPPPPPPPPPPPGFGGPPPPPPPPPPAAATPARGALLADIHKGRALKKTVTNDRSAPLVAKASSGGPGPSPLGAPPIPGLPKTPGGLAPPVPGLRARSNSDQSDRAQPAASGMDGPPQLAGLFAGGMPKLRKTGGGVDTGANRGASYLSDSEAPPRTAPRPPAAAAPPIPGRPFLPGTNSAPSLPKKGPPPPIGKKPPPPPPAGSRKPSSTVSPAAPPPPPPAAAPRPPPAPARSQPLPPPPPASTSNISQSIAAQAAIRAASSVAPPPGAAPPPPPPPPPSNGPPRLAPPSSPPPALAPPRPPAAAPAPPPPPPPSAAPAPPPPALSHSASSASGRASMLSMLDPSNFTLAPNGGGAKTPSPGRGPSPSPGLSAASGGGERYVVQDSRWRFHGEENFPKPRNFVGGPRKYRAGRGSSVPLDLSAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SKY0</accession>
    <name>A0AAN6SKY0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA helicase Pif1-like 2B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_21567</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU855023">
        <property type="protein sequence ID" value="KAK4031183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SKY0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049163">
        <property type="entry name" value="Pif1-like_2B_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21530">
        <property type="entry name" value="Pif1_2B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like 2B" evidence="1">
        <location>
            <begin position="29"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4031183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="68" mass="7747" checksum="99AB8D8F772A81B4" modified="2024-10-02" version="1" fragment="single">GEATRYLSINKVKNTLVDRDINVIVLSPDFLFSLNFPSIMLAILELKVNALIIILRNIDLEEGLYNRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SL14</accession>
    <name>A0AAN6SL14_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ThrRS/AlaRS common domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_41243</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854623">
        <property type="protein sequence ID" value="KAK4032321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SL14"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006419">
        <property type="term" value="P:alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.980.10:FF:000008">
        <property type="entry name" value="Similar to alanyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051335">
        <property type="entry name" value="Alanyl-tRNA_Editing_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43462">
        <property type="entry name" value="ALANYL-TRNA EDITING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43462:SF2">
        <property type="entry name" value="THREONYL AND ALANYL TRNA SYNTHETASE SECOND ADDITIONAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alanyl-transfer RNA synthetases family profile" evidence="5">
        <location>
            <begin position="1"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="57"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4032321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="290" mass="30951" checksum="43AB3FDBC1AEF9A5" modified="2024-10-02" version="1">MTAPTQLIYQQDGERLLHSAKILSIVPVTDLTAPDQALIKDASEIEHAVITDSTVFHVQGGGQPSDTGTMTPSSSSSSSSSSSSNVVAATAVSTFEVKSVRQPAQGSEVLHFGRFISADGTTSTPARFDAGEQVQQHVDAEKRNLHSRLHTAGHVLSLAIHALCREGVLPPLTESKASHYPDSAAVVFNGTIEGKHKEAIQAKADEFVRSARPVKIHWWPMEELLAKCHGTSEGFALPAGETMGRVVEMEGLGSYPCGGTHVRDCSQVGKIEVKKISRSKGTSKVSYRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SM29</accession>
    <name>A0AAN6SM29_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_20764</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854645">
        <property type="protein sequence ID" value="KAK4032130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SM29"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051711">
        <property type="entry name" value="Stress_Response_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540">
        <property type="entry name" value="THIAMINE REPRESSIBLE GENES REGULATORY PROTEIN THI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540:SF2">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="19"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="220"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="278"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="243"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="278"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="388"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4032130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="411" mass="42350" checksum="A7BB58B66BC75F62" modified="2024-10-02" version="1">MADQLDSDSAPQRKRIAVACGRCRKRKIRCSGDPGQGQPCSNCKNAGVEQCQFLRVSSREAPIRHEPGDFGYSVGDARVYASRTPVGSGLPYPQDLPTLGSSDVLGSYRGGSAYPYTPASKAYYPAMHAYGAPYSEDFEFGLGVGSPPVMNPESVGMMPSHWSSGARAKPPSFSSMYMDSEGAYSSYGSASLLHRPSHSVSSDSPNFSFSGVAASLPLSSTPGPDRLLPNPAGRSSALPYPGSAKPSTPASTSAASTLADVATAASYAGGFETSGLSFSSTSSSGLSSHPSSSSRSNSDSYSGPESIFSEQERSLQSQGSAFDMGGYTASPRRGSGTGGSGSSHAYVPGESAHEAAAHHHSSHHGLPAAYMSDAPSSPIAHRPSQCLASGTGSTGHATHTDDRQVAVASRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SMJ0</accession>
    <name>A0AAN6SMJ0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome b561 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">C8A01DRAFT_49577</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854503">
        <property type="protein sequence ID" value="KAK4033911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SMJ0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd08760">
        <property type="entry name" value="Cyt_b561_FRRS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797:SF1">
        <property type="entry name" value="CYTOCHROME B561 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05805)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00665">
        <property type="entry name" value="B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042819465" description="Cytochrome b561 domain-containing protein" evidence="9">
        <location>
            <begin position="22"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="10">
        <location>
            <begin position="88"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="51"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK4033911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="277" mass="28700" checksum="4247EB453D159596" modified="2024-10-02" version="1">MNAILARAALALLGKPAPLLAPPLGGTLAGAVQAQQFGGFNGNGDPSGSASGSGSGSGPSGSSGSPGSGFSSFGANANLAAAARTRATHGILAAVTMVVLFPLGAIMVRVLPAGRIALWTHGLIQMAAVCALVAAAALGVEIVMEVNEGAGDRINLLDDNRVMSHFIIGLVVMTLLLVQPFLAAIHHVEFKETGKRHAASYAHLFNGRVCITLGIANGGLGLWLAGAPDKYKIAYVVAAVATWTLWMLTAVWTERQLWKKSGKTWRRRKLREGDVAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SN19</accession>
    <name>A0AAN6SN19_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pre-rRNA-processing protein TSR2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_39090</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TSR2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854480">
        <property type="protein sequence ID" value="KAK4034421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SN19"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019398">
        <property type="entry name" value="Pre-rRNA_process_TSR2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21250">
        <property type="entry name" value="PRE-RRNA-PROCESSING PROTEIN TSR2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10273">
        <property type="entry name" value="WGG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="68"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="163"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="171"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4034421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="227" mass="25234" checksum="BE52066963E04DE3" modified="2024-10-02" version="1">MASTASPSPATCQSTFEQGVALSLHLWEALSLAVQNNWGGPDSADKRDWFAGAVVDLFPDVSRLTPAQLQQKTTAQQTQPQQQAQSQPQSAQNGTTTEEPDQEDVEAVLLQVMLDEFEVNVDDESAFEVAEQVVRLRGECLRGKLDGVDALRRRWEGKKGNKVVFKKAEDQDGDETDWDTDDDEEEEEGESGEDVEMGEAPPAPPRREKEEPEVDEEGFTKVSRKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SNM6</accession>
    <name>A0AAN6SNM6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA excision repair protein ERCC-8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_39631</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854504">
        <property type="protein sequence ID" value="KAK4033898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SNM6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031464">
        <property type="term" value="C:Cul4A-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000109">
        <property type="term" value="C:nucleotide-excision repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006283">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042238">
        <property type="entry name" value="Rad28/ERCC8/Ckn1/ATCSA-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46202">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46202:SF1">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="67"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="136"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="228"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="296"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4033898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="499" mass="52114" checksum="343AD2ADCEEBE23E" modified="2024-10-02" version="1">MNPLLFERSSGSLGPNEFARIQTASLLGSFAAALRFRFDGGERAVSDTAGRRSDDLGSGDEASRASLWAHQAGVSALALERFDGRIMVSGGSDATIKLWDLEQCPNPSQSHIYRPVSVVPRAGSDSSSPRPSSASAAGHRFGITHLSFYPFDSAAFLSCSHDQTLKLWSTERASVFGSFALGARAYTHAISPIASHLLVACGTQHPAVRLVDLRSSAAVQSLVSPGQLGGSAGATLAVAWSPAHEHVLAAGSVDGAVRIWDVRKSNGLVALLDQEDIIGLADGEMSLPGRTPRLAAKAHAGPVNGLAWTDDGAYLISAGHDRRIRVWDAATGANTLANFGPSIRNSQLSTLTMFASPIGLTPPGSELLFFPNETEILVMDLHEGSIVTRLRGMGPAVASVGTQRGGERTIRNCVTSLVWRGAGGGGSSSGVAMGGSNAAGGVFSGHLDGQIRVWLPQLEGADGEAEDNSAEDAYGAKSKKRKALDDAFRSLMGKQVTFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SNN2</accession>
    <name>A0AAN6SNN2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_39609</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854503">
        <property type="protein sequence ID" value="KAK4033913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SNN2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4033913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="384" mass="42336" checksum="FEAC18A8C886D51A" modified="2024-10-02" version="1">MDALANATGNASWFPRGLEDNDGWRVDAATIVLLAIIGDPRPDEFARAVTASSLVMLPRLVPAMQLLNAARPAQLPQTTAVVSQISGPSEDDVDRRETVGYFVNALRQLDKVPRRAFRLLRVRHNQQVRLSRDIEVVEHYKMIRVPPSHLVHGVLLLGLVLVVGLLVAAALWKDGPALISIALMGFASSLIGYASSWTTRDAYYETRAGAKSAAPITIVIKTFGFGLTVVRCDETIQNELYLGILDRCSYRSRGARCGALVAAGSVALMVSVIMLGNATWKSQLSVTVSYVFLNAVFWAVSLLPRHAFWDMSRYQVDDITPADAVNAHQGTDTGPDSVEGRVSLARTLWWKRWLAEAQQAVDEGNRPWPAVKRQHEMMQEECCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SP14</accession>
    <name>A0AAN6SP14_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">A-kinase anchor protein 7-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_49361</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854490">
        <property type="protein sequence ID" value="KAK4034200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SP14"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1140.10">
        <property type="entry name" value="Cyclic phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019510">
        <property type="entry name" value="AKAP7-like_phosphoesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009210">
        <property type="entry name" value="ASCC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13360">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13360:SF1">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10469">
        <property type="entry name" value="AKAP7_NLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="A-kinase anchor protein 7-like phosphoesterase" evidence="3">
        <location>
            <begin position="73"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="201"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="349"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="421"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="273"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="293"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4034200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="712" mass="76103" checksum="60C162C2D063880A" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SP20</accession>
    <name>A0AAN6SP20_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_49284</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854485">
        <property type="protein sequence ID" value="KAK4034303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SP20"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052718">
        <property type="entry name" value="NmrA-type_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47129:SF1">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47129">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="1">
        <location>
            <begin position="2"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4034303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="325" mass="35505" checksum="4ED5E0BD6F46D473" modified="2024-10-02" version="1">MTIGIFPASGGLGTSTYTHLLKLVPNDQVILINRNPENVPQQYIDAGVRVRKASYESTFSELEYAFSGIDVLFLISYPSHVHDYRIKVQLPAVDAAKKAGVTHIFYSSLGFAGDHQSTSLAEVMQAHLDTERHLARLAAAPASSFTYTSIREGLYAESTPIYTAFFDPRSVAESSSNNGEILIPHDGSGPGVAWVKRDELGEASGRLIASYYHDHSKGGKEQGGFQFVNRTVLLTGPRVWSLAETVAVLGEIAGREVRIRAVPVDEYVRLPQVLAKFGSEEMARMWATAWDAIRAGETAVVAPELAAILGREPEAFEVAVRRHFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SP89</accession>
    <name>A0AAN6SP89_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Beta-fructofuranosidase, cell wall isozyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_49082</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854475">
        <property type="protein sequence ID" value="KAK4034543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SP89"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004575">
        <property type="term" value="F:sucrose alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005987">
        <property type="term" value="P:sucrose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18621">
        <property type="entry name" value="GH32_XdINV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.560">
        <property type="entry name" value="Exo-inulinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001362">
        <property type="entry name" value="Glyco_hydro_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013189">
        <property type="entry name" value="Glyco_hydro_32_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013148">
        <property type="entry name" value="Glyco_hydro_32_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42800">
        <property type="entry name" value="EXOINULINASE INUD (AFU_ORTHOLOGUE AFUA_5G00480)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42800:SF3">
        <property type="entry name" value="GLYCOSYL HYDROLASE FAMILY 32 N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08244">
        <property type="entry name" value="Glyco_hydro_32C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00251">
        <property type="entry name" value="Glyco_hydro_32N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00640">
        <property type="entry name" value="Glyco_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 32 N-terminal" evidence="5">
        <location>
            <begin position="11"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 32 N-terminal" evidence="5">
        <location>
            <begin position="145"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 32 C-terminal" evidence="6">
        <location>
            <begin position="315"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4034543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="461" mass="50125" checksum="62154B378F655C7E" modified="2024-10-02" version="1">MGWLNDPCAPGTEWGSISWVCAHSSDFVSWTAFDTPSLTPTATQDPCGVFTGCLSPETLEPGSLTVFYTSVSHLPIHHSLPYKGGAEVLHIATSLDSGRTWSRFEGDPVLPEPPAHLGVTGWRDPFVAPWPSLSVELGQPADTLYGTNWEVANFISLPGPEPSDVHDFLILNVEGRLQNSSSKDQTQFRVDHAQMWMCGRIRREDGQAVTMDYQYGSRIDHGAYYAGNSFWDPKIQKQAIIGWLIGPGPGDSIASVGLKRENDGPAAATSGEGMTAYTATTLCARPDERLAKLRSGPRILPLEDFERGATLSLPHGSVAWEKDLAFDMGASVGRVGLVIEHRPPDTEKRSRTAIFYDRQAEVLTIVRGKSTSVPGVNISDEVAPHPLFVFHHLAVGIFFDASALEVFANNRAALSTRVYPDTGRCFGITPCVERTGGEPDDRGFGALHVLEPFLPVVETVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SPD7</accession>
    <name>A0AAN6SPD7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Bromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_17735</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854438">
        <property type="protein sequence ID" value="KAK4038164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SPD7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04369">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15398">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15398:SF4">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN 8 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="5">
        <location>
            <begin position="818"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="111"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="192"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="919"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="994"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="162"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="234"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="261"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="327"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="359"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="411"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="435"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="471"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="518"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="554"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="726"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="739"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="770"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="939"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="1020"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1030"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4038164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1052" mass="110681" checksum="229A27121E6A932B" modified="2024-10-02" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SPS9</accession>
    <name>A0AAN6SPS9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_48522</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854450">
        <property type="protein sequence ID" value="KAK4035262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SPS9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4035262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="121" mass="13088" checksum="E9F7A1FF926CCF2B" modified="2024-10-02" version="1">MEQAPRTTQKAPKKAHPHHPHHVVPKHESGYTDEAAEECHDLIDRAEEDAHLHEPGSMYSTTDTPEHVHRMKGKGGLEGSGSTGSTGGGSVTQKVQETGKNVSETVGQKVGQMKEKMGMNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SPW4</accession>
    <name>A0AAN6SPW4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_47753</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854422">
        <property type="protein sequence ID" value="KAK4038674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SPW4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12254">
        <property type="entry name" value="RRM_hnRNPH_ESRPs_RBM12_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4038674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="725" mass="80386" checksum="01C5DB19D3C35FBB" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SQ04</accession>
    <name>A0AAN6SQ04_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_17845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854442">
        <property type="protein sequence ID" value="KAK4038030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SQ04"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="131"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4038030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="261" mass="28565" checksum="F25D2AAFC6EF9E37" modified="2024-10-02" version="1">MSLTRGGSTLANMRTVLVKVSPAPTTLSERRAVLGVLKKYAVVDVFKKLHDPSHFISTVAQEQMALSLVAKSPLQFDYAARQGRSNRTTTAPKTFLVKITEKPDYSHKTRIREALIYGRWPSPGPEPEPQPEFGQQQQQQQQQQYGDRDPAALFREDSLPRAALRAACPRDMAWAGLTDWESAGQLDGDGGAGLSHKGDYAQARLMKRGRNDSWFESLAEVYLARHEREESREGGLGKDAGVEEGGAAATVGGVIGGGRRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SQE9</accession>
    <name>A0AAN6SQE9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_37270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854419">
        <property type="protein sequence ID" value="KAK4038782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SQE9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF59">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="84"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4038782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="321" mass="35168" checksum="401E1E11C110BAD7" modified="2024-10-02" version="1">MVAPYSLDAAIDSFFESNPTTATRRQCDDFALAHGTPVTPVQIQGMFSYTVLVGTDKIFQFRISSSSIDMDLLNLVTTTHREFVPRCKYHGTVGASQPLSIYEMDKLPGMSYILARDPDSVACQQRTVHELATFFAQSWNNAQPPSSATPNPFLAEFTQALTTLSTSLPAHFTPRLTALLHRLPAAFSALPLALTHGDLCEMNLLVDPATGRLTGVLDWAEARVLPFGLALYGLENALGWMDGGGWHYFEQAPALREGFWQVFRERAAGVGDEEGVMEGIEVARMVGVFYRYGFVFEGREVVRAVGEGEMGYLDAFCGGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SQI8</accession>
    <name>A0AAN6SQI8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">mitogen-activated protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">C8A01DRAFT_37677</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="1"/>
    <dbReference type="EMBL" id="MU854431">
        <property type="protein sequence ID" value="KAK4038363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SQI8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050538">
        <property type="entry name" value="MAP_kinase_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016">
        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016:SF56">
        <property type="entry name" value="MAPKK KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="112"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK4038363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="371" mass="41411" checksum="ABE648728C397413" modified="2024-10-02" version="1">MCYDRSGGQSSQFFGADAVPFWPDYPRKVVVQDGLNTNLGMGGARQNLVQFRLRWHCSNGGLARMLEQRENARLEENPRFAKTLFDADTAAPSRMEMRAHIAGPPRPLTRWCAVGPALGSGEFGTVHKARDLDSGQLMAVKRVRSPLGPAGQLERSMVKREVEILSGIRHEHIVDYISSQVVMDQGHPMTDIFMGLKDGNLHGLLLRTADTGHLQLVAEVVFHQMLHALDYLAGKGIIHRDVKPENIMYVMDAGEYVFQLGDFGLSCWENQLFHPGQRQTSKADVWSLLVTVLWTLDVGGFRKLERTNEPYEEVQATILAAVRLPDCVAMREMAVVEPASRASAAQMLKEHFSRREAPKLTTLAKRVPGQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SR82</accession>
    <name>A0AAN6SR82_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">VID27 cytoplasmic protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_36873</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854408">
        <property type="protein sequence ID" value="KAK4039186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SR82"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040458">
        <property type="entry name" value="Vid27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013863">
        <property type="entry name" value="VID27_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040979">
        <property type="entry name" value="Vid27_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040768">
        <property type="entry name" value="Vid27_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31913">
        <property type="entry name" value="VACUOLAR IMPORT AND DEGRADATION PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31913:SF0">
        <property type="entry name" value="VACUOLAR IMPORT AND DEGRADATION PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08553">
        <property type="entry name" value="VID27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17748">
        <property type="entry name" value="VID27_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17747">
        <property type="entry name" value="VID27_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vid27 N-terminal" evidence="4">
        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Vid27 PH-like" evidence="3">
        <location>
            <begin position="250"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar import/degradation Vid27 C-terminal" evidence="2">
        <location>
            <begin position="430"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4039186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="813" mass="91779" checksum="EBF91A68E051E314" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SS84</accession>
    <name>A0AAN6SS84_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-reducing end alpha-L-arabinofuranosidase</fullName>
            <ecNumber evidence="4">3.2.1.55</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_34728</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Alpha-L-arabinofuranosidase involved in the degradation of arabinoxylan, a major component of plant hemicellulose. Acts only on small linear 1,5-alpha-linked L-arabinofuranosyl oligosaccharides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides.</text>
            <dbReference type="EC" id="3.2.1.55"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; L-arabinan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 51 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.55" evidence="4"/>
    <dbReference type="EMBL" id="MU854361">
        <property type="protein sequence ID" value="KAK4041209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SS84"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046373">
        <property type="term" value="P:L-arabinose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010720">
        <property type="entry name" value="Alpha-L-AF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055235">
        <property type="entry name" value="ASD1_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43576:SF3">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43576">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06964">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22848">
        <property type="entry name" value="ASD1_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00813">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-L-arabinofuranosidase C-terminal" evidence="9">
        <location>
            <begin position="310"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4041209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="508" mass="56814" checksum="B58D965048841FEB" modified="2024-10-02" version="1">MATFTRIQEGESPSITIHPSYKIAEIDNNIYGGFTEHMGRCIYGGIYDPGNPLSDENGFRKDVIEAFKELNVPVVRYPGGNFVATYNWLDGVGPKESRPSRPELAWIGVETNEFGTDEFMKWCEAVGTEPYLCLNMGTGTLADALGWLEYCNSDRNTYYANMRRKNGREKPYNVKYWALGNECWGPWQVEQLTKEDYAKKAYQWAKALKLLDPTITLILCGETGYSSWDHYVLKECVRWDVHGLGDENNTKSLIDMHSIHVYTADKEHLANATAPRSAERAIQMASALIDLARIENKVPASIPKQKICFDEWNVWDPIRAPGEQGAEEKYTLSDALAVAVWLNAFIRQAKDMGMANIAQSVNVISPLMTSKDGLVKQTIWWPLLLFSKYMRGHTIALNVAAPEYTGRTQPAWIRAAIETPYLDCSATLGADGFVNLAVANLNEEQDYEVALDGLKADKVEVFVVSGDNVGVTNTAGEQKVGIKESAWDGKGKYTFGRHSLTLLRWKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SS98</accession>
    <name>A0AAN6SS98_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_35586</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854377">
        <property type="protein sequence ID" value="KAK4040445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SS98"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4040445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="312" mass="35964" checksum="C8BFE22591B97D99" modified="2024-10-02" version="1">MSEALAHAIHINLSLSNEAQPSPPWGALPAEQYLIRNWNWFSPQPGPDQMRALVRAFLALDDIPKDWDVQRVPTDDEVRTILQPWRPARWRDAVWLRTHYGDGSDAKFAEWRDMDEDYDPNYDEETVLWTVLDDVGVFSFGDEWWCVFDVLPELAGPLRRHARGAPYVDKDKMQELGRDVERPLSSLAGGEHERLEDAAAILEAEYGEHGERLQAEAVSTFLLVADAGAWETDCLRLLYLDGKGNVVRHSAVEVSEAWETRNYWMGHKFRESLWWPHKHHLMTGERFEPGSELADKYRARGELGRLLYGLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SSN4</accession>
    <name>A0AAN6SSN4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="8">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_34855</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the tannase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="8"/>
    <dbReference type="EMBL" id="MU854363">
        <property type="protein sequence ID" value="KAK4041122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SSN4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030600">
        <property type="term" value="F:feruloyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011118">
        <property type="entry name" value="Tannase/feruloyl_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938:SF13">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07519">
        <property type="entry name" value="Tannase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042667915" description="Carboxylic ester hydrolase" evidence="8">
        <location>
            <begin position="22"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4041122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="421" mass="45555" checksum="10C52E194BFD5E30" modified="2024-10-02" version="1">MSVSLFVVCSATTFSPPSVYGAEILSIEASLVTNYSASVPDVYRYTQPSTQLQNATFCNVTVLYTHPGQNDKVIVEAWLPVDNWNGRFQAVGGGGWVPGRFFLSYDAMNGALADGYATITTDAGLGASLDATPWALLSPGNVDLLLLQNLASVSLNDEAIIGKSLIKSFYGKVPEYSYWNGCSQGGRQGLMLAQRYPTAYDGIATGAPAIHWTKLFSYLQWPQRRPHGNCPDLLFVAGDPDLDFTNLTHAEFDRLAHLSGQMYNSVISTDDPDLSAFCEAGGKLVTFHGLADSIIPPKGTEQYYNAVASVVPDIDGFYRHYEVPGLGHCFGGRGGQPTNLFAQLRAWVEHGTAPGESLGQITDLEGKTQHRILCPYPQRARLDSKCGNSTLAACWSCVDHGGVVDVLEAIYEHRGVPKAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6ST04</accession>
    <name>A0AAN6ST04_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Diphthine methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_15192</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854365">
        <property type="protein sequence ID" value="KAK4041016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6ST04"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061685">
        <property type="term" value="F:diphthine methylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052415">
        <property type="entry name" value="Diphthine_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46042">
        <property type="entry name" value="DIPHTHINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46042:SF1">
        <property type="entry name" value="DIPHTHINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="44"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="61"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4041016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="411" mass="45783" checksum="FA8AD662C26152F2" modified="2024-10-02" version="1">MAEEGKLVRSLRSQVLDLPPSCVEFCPAFPSYFVVGTYSLQLESAEPKNADRDEEAEEDGQPSQPKQPQSRNGSIIVFRLMDGNITHVQTVPQPSALLDLRFNPHDGRRDICAVVSSTATVALFRLSPDEDEPLKHLKTMDIAAMSQGEIEPTPGEEIIFTSFGWHPSRADMMAITTSTGHVYILHLPTFDGNWELNSEPVITHTLEAWCVVIAPTPAAPMRPGELSKLSFRVYSGGDDSMLRSRTCTWSEGSLAESLPALEARGHDAGVTAILPLFVQEDGHELVVTGSYDEHIRLFLTPPFGRPKNLAESVLAGGVWRLNLIDLDTTPNQRYSWRARILASCMHAGTRVVELLETVDGEHRFDVLWRFEEHESMNYGSDFQPGQKQGRLSVVSTSFYDKLLCLWEIEMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6ST62</accession>
    <name>A0AAN6ST62_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">26S proteasome complex subunit SEM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_14655</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the DSS1/SEM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854354">
        <property type="protein sequence ID" value="KAK4041647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6ST62"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13768">
        <property type="entry name" value="DSS1_Sem1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007834">
        <property type="entry name" value="DSS1_SEM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16771">
        <property type="entry name" value="26 PROTEASOME COMPLEX SUBUNIT DSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16771:SF0">
        <property type="entry name" value="26S PROTEASOME COMPLEX SUBUNIT SEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05160">
        <property type="entry name" value="DSS1_SEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01385">
        <property type="entry name" value="DSS1_SEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU369057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4041647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="98" mass="10981" checksum="E8FE7AA9B62960FB" modified="2024-10-02" version="1">MASSQTTTKKDDKPAAESKPEQQQQPGAEQKTAALEEDDEFEDFPVDDWEQEDTEAAASGSGATQHLWEESWDDDDTSDDFSAQLKEELKKVEASKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SU45</accession>
    <name>A0AAN6SU45_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Transaldolase</fullName>
            <ecNumber evidence="3 9">2.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_14200</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the rate-limiting step of the non-oxidative phase in the pentose phosphate pathway. Catalyzes the reversible conversion of sedheptulose-7-phosphate and D-glyceraldehyde 3-phosphate into erythrose-4-phosphate and beta-D-fructose 6-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:17053"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Carbohydrate degradation; pentose phosphate pathway; D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transaldolase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.2" evidence="3 9"/>
    <dbReference type="EMBL" id="MU854345">
        <property type="protein sequence ID" value="KAK4042143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SU45"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004801">
        <property type="term" value="F:transaldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009052">
        <property type="term" value="P:pentose-phosphate shunt, non-oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00957">
        <property type="entry name" value="Transaldolase_TalAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000088">
        <property type="entry name" value="Transaldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001585">
        <property type="entry name" value="TAL/FSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004730">
        <property type="entry name" value="Transaldolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018225">
        <property type="entry name" value="Transaldolase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00874">
        <property type="entry name" value="talAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683">
        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683:SF18">
        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00923">
        <property type="entry name" value="TAL_FSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01054">
        <property type="entry name" value="TRANSALDOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00958">
        <property type="entry name" value="TRANSALDOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0704">Schiff base</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4042143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="319" mass="34447" checksum="938A4BF2585A941C" modified="2024-10-02" version="1">MANSLEQLKATGTVVVSDSAIGKYKPQDATTNPSLILAATKKAEYAALLDAAVARAKSEGGSIDQQVDSALDNLLVEFGTKILEIIPGKVSTEVDAAFSFSTKASVDKALHIIDLYKKAGVSKDRVLIKIASTWEGIKAAEILQRDHGINCNLTLMFSLPQAIAAAEAGAFLISPFVGRILDWFKAATKKDYAKEEDPGVASVKAIFNYYKKYGYKTIVMGASFRNTGEITELAGCDYLTISPNLLEELVNSDAAVPKKLDAAGASSLDIEKKTYINEEANFRFDFNEDQMAVEKLREGISKFAADAVTLKSIIKAKLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SUD5</accession>
    <name>A0AAN6SUD5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phosphoserine transaminase</fullName>
            <ecNumber evidence="4">2.6.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">C8A01DRAFT_44108</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>4-(phosphooxy)-L-threonine + 2-oxoglutarate = (R)-3-hydroxy-2-oxo-4-phosphooxybutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:16573"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58452"/>
            <dbReference type="ChEBI" id="CHEBI:58538"/>
            <dbReference type="EC" id="2.6.1.52"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-phospho-L-serine + 2-oxoglutarate = 3-phosphooxypyruvate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:14329"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:18110"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57524"/>
            <dbReference type="EC" id="2.6.1.52"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.52" evidence="4"/>
    <dbReference type="EMBL" id="MU854334">
        <property type="protein sequence ID" value="KAK4042892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SUD5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004648">
        <property type="term" value="F:O-phospho-L-serine:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000082">
        <property type="entry name" value="Phosphoserine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000006">
        <property type="entry name" value="Phosphoserine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00160">
        <property type="entry name" value="SerC_aminotrans_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022278">
        <property type="entry name" value="Pser_aminoTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003764">
        <property type="entry name" value="PRK05355.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43247">
        <property type="entry name" value="PHOSPHOSERINE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43247:SF1">
        <property type="entry name" value="PHOSPHOSERINE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000525">
        <property type="entry name" value="SerC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5 13" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0718">Serine biosynthesis</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="12">
        <location>
            <begin position="120"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK4042892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="427" mass="45766" checksum="5C23643604037608" modified="2024-10-02" version="1">MPTRADITYFGAGPAALPTDVLETAAQALLDFQGTGLGIAEHSHRSELATNIINEAKADLASYLDIPAAEYEVIFMQAGGTGEFAASVYNLVGAWVARQHAAVLKELGSAADEGAVTAALRARVETGLKLDYIVTGGWSLKAYQEAVRLLGPEYVNLAADARAINDGKFGKIPDQSTWKLSNDAALVYYCDNETVDGVEFPEFPAVLAPRPDGTGPVVVADMSSNILSRRVPVSNYSLLFFGAQKNLGCTGVTVAVAKKTLLPPVTTQPAPALMRKLGLPIPPIMLQYETIAKNNSLYNTLSIFDVYIAGQVLKKLLKTYPDKVDGQQAVAEKKASIIYGALEAHPDVYRIVPDKAVRSRMNICFRVTKNGNVDDTEKAFLKEATSQGLTGLKGHRSVGGIRASNYNSIPLEGAEKLARFIEAFAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SUD8</accession>
    <name>A0AAN6SUD8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_44499</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854340">
        <property type="protein sequence ID" value="KAK4042486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SUD8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="148"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4042486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="264" mass="28900" checksum="B7D19E2F3A09B5AB" modified="2024-10-02" version="1">MLCGIRSTSNHHHHSLLRSFRSHRSLRHPKNSQESLSSEEEEMHHHHRHLPSDASSLARPSLDSTSSRRTDMSIDWDPLRLHPSVAAGPSPPLRDAFSESTSRWYQPHELRQARSSQALRQASSPSSHQPASNNTVIYDGFDFGFNNNPTPTTIHTTSPSSRGMMARPPSPTPSDASSVCSLSLSGSSSDDSLPLEEEEMGLCLGLAPAPAPRPRAHPRPCLDGGAGSGNDAEYFIRRGGWKRRGIVFVNSEAPLAGEDETFEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SUH0</accession>
    <name>A0AAN6SUH0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">C8A01DRAFT_13833</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854339">
        <property type="protein sequence ID" value="KAK4042576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SUH0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043335">
        <property type="term" value="P:protein unfolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19499">
        <property type="entry name" value="RecA-like_ClpB_Hsp104-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000120">
        <property type="entry name" value="ATP-dependent chaperone ClpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000025">
        <property type="entry name" value="ATP-dependent Clp protease subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000010">
        <property type="entry name" value="Chaperone clpB 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050130">
        <property type="entry name" value="ClpA_ClpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638:SF176">
        <property type="entry name" value="HEAT SHOCK PROTEIN 78, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="9">
        <location>
            <begin position="118"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="9">
        <location>
            <begin position="516"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="domain" description="Clp ATPase C-terminal" evidence="10">
        <location>
            <begin position="694"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="331"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK4042576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="797" mass="87672" checksum="C36552BE5C1EEE7A" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SV56</accession>
    <name>A0AAN6SV56_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Roadblock/LAMTOR2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_32080</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GAMAD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854324">
        <property type="protein sequence ID" value="KAK4043762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SV56"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.30">
        <property type="entry name" value="Dynein light chain 2a, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004942">
        <property type="entry name" value="Roadblock/LAMTOR2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10779">
        <property type="entry name" value="DYNEIN LIGHT CHAIN ROADBLOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03259">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00960">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103196">
        <property type="entry name" value="Roadblock/LC7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Roadblock/LAMTOR2" evidence="3">
        <location>
            <begin position="13"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="49"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4043762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="138" mass="14469" checksum="75FBD330F3B4975F" modified="2024-10-02" version="1">MSDTALGTGPDALDETLGRLSKKAGVRAAIALDRASGAILKTSGQVGSIRTTKTSGSSVPAVGPFANNEGNANSTNHDQGAEELASMVWNFVSTAGSLVQELDTEDEVKLLRLRTKKQEFVIVPDAKYLLIVVHDTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SVA9</accession>
    <name>A0AAN6SVA9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_13008</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854327">
        <property type="protein sequence ID" value="KAK4043446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SVA9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06587">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058997">
        <property type="entry name" value="YycE-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058998">
        <property type="entry name" value="YycE-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22659">
        <property type="entry name" value="YycE-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22658">
        <property type="entry name" value="YycE-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="4"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4043446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="720" mass="79072" checksum="3F63916305D3DF6F" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SVE3</accession>
    <name>A0AAN6SVE3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Phosphoenolpyruvate/pyruvate domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_42690</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854318">
        <property type="protein sequence ID" value="KAK4044509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SVE3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06466">
        <property type="entry name" value="p23_CS_SGT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1130.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007051">
        <property type="entry name" value="CHORD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039790">
        <property type="entry name" value="CHRD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46983:SF3">
        <property type="entry name" value="CHPADIPLOID STATE MAINTENANCE PROTEIN CHPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46983">
        <property type="entry name" value="CYSTEINE AND HISTIDINE-RICH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04968">
        <property type="entry name" value="CHORD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51401">
        <property type="entry name" value="CHORD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CHORD" evidence="6">
        <location>
            <begin position="244"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="CHORD" evidence="6">
        <location>
            <begin position="364"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="CS" evidence="5">
        <location>
            <begin position="449"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="319"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="348"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4044509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="559" mass="60638" checksum="98C5F7AA7E32282F" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SVG0</accession>
    <name>A0AAN6SVG0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Actin-related protein 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Actin-like protein 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">C8A01DRAFT_32266</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin family. ARP3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854326">
        <property type="protein sequence ID" value="KAK4043538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SVG0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044396">
        <property type="term" value="P:actin cortical patch organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10221">
        <property type="entry name" value="ASKHA_NBD_Arp3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000029">
        <property type="entry name" value="Actin-related protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000006">
        <property type="entry name" value="Actin-related protein 3 (ARP3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="40"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK4043538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="438" mass="47590" checksum="99D2DD946E48A3C9" modified="2024-10-02" version="1">MANQTPAVVMDNGTGFSKLGFAGNDSPSFVFPTAIATKGGAAGGGSGSGRPAVANKPSFLTGGAGPTGHLSGKRGTEDLDFFIGDEAISAASGPGYGLHYPIRHGQIENWDHMERFWSNSIFKYLRVEPEDHYFLLTEPPLNPPENRENTAEIFFESFNCAGLYIAVQAVLALAASWTSSKVTDRSLTGTVIDSGDGVTHVIPVAEGYVIGSSIKSIPIAGRDITYFVQSLLRDRGEPDSSLKTAQEIKEAHCYVCPDIVNEFGKYDRDRSRFMKHVVAQPGGREVTVDVGYERFLAPEIFFNPEIYSSDFLTPLPVVVDGVIQSSPIDVRRGLYKNIVLSGGSTLYKDFGRRLQRDIKQLVDARIRQSEVRSGGAKSGGLEVQVITHKRQRHGPWFGGSLLGQTPEFRSYCHTKAEYQEYGPGIVRRFALLGGPGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SVI1</accession>
    <name>A0AAN6SVI1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_42538</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854317">
        <property type="protein sequence ID" value="KAK4044629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SVI1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="449"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="637"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="743"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="487"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="521"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="788"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="823"/>
            <end position="834"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4044629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="889" mass="95357" checksum="6DF05CABE6FE06E7" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SVM4</accession>
    <name>A0AAN6SVM4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">LSM complex subunit LSM5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LSM5</name>
        <name evidence="12" type="ORF">C8A01DRAFT_30944</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">LSm subunits form a heteromer with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854316">
        <property type="protein sequence ID" value="KAK4044764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SVM4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01732">
        <property type="entry name" value="LSm5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000003">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033871">
        <property type="entry name" value="LSm5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20971">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20971:SF0">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 10" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="11">
        <location>
            <begin position="6"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK4044764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="85" mass="9190" checksum="77E0E798B4A72578" modified="2024-10-02" version="1">MASQLLPLELIDKCVGSRIWVVMKGDKEFAGTLVGFDDYVNMVLEDVTEFDYSGNHTKLNKILLNGNNICMLIPGGEGPTGIAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SW61</accession>
    <name>A0AAN6SW61_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N(6)-L-threonylcarbamoyladenine synthase</fullName>
            <ecNumber evidence="1">2.3.1.234</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">N6-L-threonylcarbamoyladenine synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">C8A01DRAFT_11788</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>L-threonylcarbamoyladenylate + adenosine(37) in tRNA = N(6)-L-threonylcarbamoyladenosine(37) in tRNA + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="9">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the KAE1 / TsaD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="1"/>
    <dbReference type="EMBL" id="MU854316">
        <property type="protein sequence ID" value="KAK4044827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SW61"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061711">
        <property type="term" value="F:tRNA N(6)-L-threonylcarbamoyladenine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd24132">
        <property type="entry name" value="ASKHA_NBD_OSGEP_like_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000038">
        <property type="entry name" value="Probable tRNA N6-adenosine threonylcarbamoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01446">
        <property type="entry name" value="Kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017861">
        <property type="entry name" value="KAE1/TsaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034680">
        <property type="entry name" value="Kae1_archaea_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017860">
        <property type="entry name" value="Peptidase_M22_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03722">
        <property type="entry name" value="arch_KAE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00329">
        <property type="entry name" value="gcp_kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF14">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
        <property type="entry name" value="OSIALOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01016">
        <property type="entry name" value="GLYCOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Gcp-like" evidence="10">
        <location>
            <begin position="44"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="147"/>
            <end position="151"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK4044827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="360" mass="38649" checksum="905C3EC9FBA87C8F" modified="2024-10-02" version="1">MGIDITKKKRRIALGCEGSANKLGIGVILHEGDLTTPTSTVLSNVRHTFVSPPGTGFLPKDTAHHHRSFFVRTAKQALSDANITLAEIDCISYTRGPGMGAPLTSVAIAARTLALLWDKPLVGVNHCVGHIEMGRAITGADHPVVLYVSGGNTQVIAYAEQRYRIFGETLDIAVGNCLDRFARALAISNDPAPGYNIEQLAKHGGRVLLDLPYAVKGMDCSFSGILTRAEELAAQMKAGGGKGPDGEPFTGADLCFSLQETVFAMLVEITERAMAHVGSNQVLIVGGVGCNERLQEMMGLMAADRGGSVYATDERFCIDNGIMIAHAGLLAYETGFRTPIEESTCTQRFRTDEVLVKWRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SWG1</accession>
    <name>A0AAN6SWG1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_31099</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854317">
        <property type="protein sequence ID" value="KAK4044603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SWG1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4044603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="132" mass="14203" checksum="4FDF713479B3127B" modified="2024-10-02" version="1">MSNSSPKDTTKDTTSTSTSKYDCPKTSSKIDSAYKTWDRIAEKIATTPSPSKVTMSNSSSKDTTSSSSVSTFSSASTLTNNTDSDKSTSTSTSKYPTWDKVAEKIASRSSESKYSFDSKKDKSGYSAADYKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SWN4</accession>
    <name>A0AAN6SWN4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Enhancer of polycomb-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_42443</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Involved in gene silencing by neighboring heterochromatin, blockage of the silencing spreading along the chromosome, and required for cell cycle progression through G2/M.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the enhancer of polycomb family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854316">
        <property type="protein sequence ID" value="KAK4044828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SWN4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024943">
        <property type="entry name" value="Enhancer_polycomb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019542">
        <property type="entry name" value="Enhancer_polycomb-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14898">
        <property type="entry name" value="ENHANCER OF POLYCOMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10513">
        <property type="entry name" value="EPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Enhancer of polycomb-like N-terminal" evidence="9">
        <location>
            <begin position="7"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="311"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="378"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="531"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="536"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="555"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4044828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="571" mass="65594" checksum="04BD7D6FEDB4944B" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P440</accession>
    <name>A0AAN6P440_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heterokaryon incompatibility protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_21511</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854939">
        <property type="protein sequence ID" value="KAK4031240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P440"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF16">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="210"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4031240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="770" mass="85333" checksum="6784A16DC7495118" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P4N9</accession>
    <name>A0AAN6P4N9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_41855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854724">
        <property type="protein sequence ID" value="KAK4031698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P4N9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4031698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="56" mass="5803" checksum="4761ABD4782C42A8" modified="2024-10-02" version="1">MAPKRGGSRRSYNPITGVYNAFVVSENAPIVRSVAAFGVAVTFLATGFAGAILCPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P7I9</accession>
    <name>A0AAN6P7I9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_21018</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854695">
        <property type="protein sequence ID" value="KAK4031823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P7I9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
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        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="41"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="83"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4031823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="190" mass="21185" checksum="0D1D7A36645021EF" modified="2024-10-02" version="1" fragment="single">HQFSILQQSLSCPTRKTLASASYNQIIRLWDTATGAHRQTLKGHDGAVNIVAFSPDSKTLASASYDRAIRLWDTAIGEHRQTLEGHDSTVSAVAFSQEGKTLASASADRTIRLWDTATGVHWQTLEVQSPLTRLSFFENGEYLETDRGMLSVTINPDASGSFWRPETSQRFSFRQGPLDHKRWKECSLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P855</accession>
    <name>A0AAN6P855_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_19546</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854524">
        <property type="protein sequence ID" value="KAK4033529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021840">
        <property type="entry name" value="DUF3433"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544:SF1">
        <property type="entry name" value="PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SPRAY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11915">
        <property type="entry name" value="DUF3433"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="195"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="562"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="677"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="717"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="779"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1202"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1202"/>
            <end position="1227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4033529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1288" mass="140451" checksum="2B2DEF6F88F6D76E" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P8A5</accession>
    <name>A0AAN6P8A5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_40963</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854592">
        <property type="protein sequence ID" value="KAK4032600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P8A5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159">
        <property type="entry name" value="CENTROSOMAL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159:SF31">
        <property type="entry name" value="CENTROSOME-ASSOCIATED PROTEIN CEP250 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90257">
        <property type="entry name" value="Myosin rod fragments"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="169"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="320"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="523"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="700"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="35"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="90"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="201"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="226"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="844"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4032600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="844" mass="92952" checksum="E2D3FD7999293137" modified="2024-10-02" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P8X8</accession>
    <name>A0AAN6P8X8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Amino-acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_19205</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854503">
        <property type="protein sequence ID" value="KAK4033919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P8X8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000039">
        <property type="entry name" value="Neutral amino acid transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF20">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="270"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="317"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="400"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="430"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="472"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="84"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4033919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="520" mass="56590" checksum="B84F3E071D2CC0FC" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P8Z5</accession>
    <name>A0AAN6P8Z5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_49563</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854502">
        <property type="protein sequence ID" value="KAK4033939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
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        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF164">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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        </location>
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            <end position="483"/>
        </location>
    </feature>
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            <end position="514"/>
        </location>
    </feature>
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            <begin position="526"/>
            <end position="545"/>
        </location>
    </feature>
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        <location>
            <begin position="80"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
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            <end position="25"/>
        </location>
    </feature>
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            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4033939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="568" mass="60915" checksum="D6CC1E456814B779" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P958</accession>
    <name>A0AAN6P958_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_19903</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854551">
        <property type="protein sequence ID" value="KAK4033112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P958"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37848">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37848:SF1">
        <property type="entry name" value="SUN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4033112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="400" mass="44823" checksum="CC5F277028E055EA" modified="2024-10-02" version="1">MGKPTSPLPGLSGSSSDADAVSLHTQPGDRAYDDDVPELQADDMPPLYSDIEPDTAANAPLLPTLHNPSYVLDVVANDGTHLQQVDANTGAEFFINACLDKNPKTLERQIQLSASKPPRPSVRVLGTHSQTVQEKGKSEKKTITDFDVSVELTPYLFSDAARGKSWTQLRTVENTEKTRRGTVLRKRAPGVKQDIEITSPKPTLAEWCHRYCASHAGVKSFVLRRQVVGFDEEKMKQKLETLVRGTNYRGKVTITFPVRDDYTIVYSDCKANRWRLTPWIVWLCYLSFLWLLTWPFLFFSTKWFEVAVAEWPFSVKEDDGTKRYVSMSEDHIYNLWGRAISRAVLDKRQGTLDQEDLIASQNAPEEPFGAALEGAPGFLRAGINAITAVNRQLGWGGDSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P981</accession>
    <name>A0AAN6P981_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_50259</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854552">
        <property type="protein sequence ID" value="KAK4033095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P981"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4033095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="397" mass="45004" checksum="997B2FE088F8B9B1" modified="2024-10-02" version="1">MSYYPSPPLPDGRRRVLVFSYDQRRWLPAGTVKVDISGDGTILSTSADPKDDRVEVPFYPPRACFPSSVATARRSELTEVDRLNCDEDLVTYSPSPGETRKVVMRSYFKASAGPGWWHETNCIMRIPRHPNIVPFDALVIDTVGGVDRAVGFTTLTARITEEPLSLNTGCVFKLKYLEQLIDAVDHLNLGSGIVHGAVTAFNLLIDPATDSIQLYNFKEAAKLGWEGDEDYFFFEYDKRRNDVKFVVLTVYDIITRQLRLNEDYREPRRLDAATFLRKRKWEKHRSVKLDKPVDDYRRLVSAWAKRRAVTDARVDHFTKASQPLSWPSLRVDPDMLDESFGFKKPGKLRRELVELGKDFLKWERPPGSAMPPPKGKRSLSTGEVVDDDASDGASAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P9Z0</accession>
    <name>A0AAN6P9Z0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Isoprenoid synthase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_40564</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854560">
        <property type="protein sequence ID" value="KAK4032978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P9Z0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046165">
        <property type="term" value="P:alcohol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001:SF69">
        <property type="entry name" value="ALL TRANS-POLYPRENYL-DIPHOSPHATE SYNTHASE PDSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4032978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="453" mass="48595" checksum="E7AFA0C4D41AB2C2" modified="2024-10-02" version="1">MQLGTGASVARGARGATRLARLRRPTCAECLRAAALDVRIPQSRVLFHSGRPNPSAWAAAVSVAGNMVSNAVSRATKGGDLPTIDPLRIVAKEMKFLTGNIRKLLGSGHPSLDRAAKYYTQAEGKHVRPLIVLLMSRATSLCPKAPQRQQATVQASAAIDTSISPLSILSDFNPSAGAETEPVLADADILPSQRRLAEITELIHTASLLHDDVIDHSVARRGAPSANLEFGNKMAVLAGDFLLGRASVALARLRHAEVIELLATVIANLVEGEFMQLKNTARDETNPRWSEDTLTYYLQKTYLKTASLISKSCRAAALLGGADAQTVDAAYSYGRNLGLAFQLVDDMLDYTRSEKELGKPAGADLELGLATAPLLFAWKTMPELGGLVGRKFANDGDVARARDLVMQSDGIQQTRALAEDYAEKAIASLSLFPDSEAKDGLVEMAVKTLQRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PA26</accession>
    <name>A0AAN6PA26_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Coatomer subunit beta'</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">C8A01DRAFT_19504</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cytoplasmic vesicle</location>
            <location evidence="1 13">COPI-coated vesicle membrane</location>
            <topology evidence="1 13">Peripheral membrane protein</topology>
            <orientation evidence="1 13">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Golgi apparatus membrane</location>
            <topology evidence="13">Peripheral membrane protein</topology>
            <orientation evidence="13">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="13">The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the WD repeat COPB2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854522">
        <property type="protein sequence ID" value="KAK4033562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PA26"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22947">
        <property type="entry name" value="Coatomer_WDAD_beta-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000016">
        <property type="entry name" value="Coatomer alpha subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.470:FF:000001">
        <property type="entry name" value="Coatomer subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006692">
        <property type="entry name" value="Beta-prop_COPA/B_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050844">
        <property type="entry name" value="Coatomer_complex_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016453">
        <property type="entry name" value="COPB2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056176">
        <property type="entry name" value="TPR_COPA_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876">
        <property type="entry name" value="COATOMER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876:SF2">
        <property type="entry name" value="COATOMER SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04053">
        <property type="entry name" value="B-prop_COPA_B_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23953">
        <property type="entry name" value="TPR_COPA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005567">
        <property type="entry name" value="Coatomer_beta'_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 13" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7 13" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 13" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <keyword evidence="5 14" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="9"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="93"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="136"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="180"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="224"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B second beta-propeller" evidence="16">
        <location>
            <begin position="318"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B TPR" evidence="17">
        <location>
            <begin position="593"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="809"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="819"/>
            <end position="846"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR005567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF23953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAK4033562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="846" mass="94060" checksum="DB5D734138B75573" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PA79</accession>
    <name>A0AAN6PA79_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_49067</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854474">
        <property type="protein sequence ID" value="KAK4034570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PA79"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4034570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="248" mass="28489" checksum="AAA474A6C347E62E" modified="2024-10-02" version="1">MSTPTTSMPPSGAPSQDEDDSIETPTIRFTSAKVLLDCIDDFPSDYLTVTHVSPPSFTRIERERDRRHRKYRFRRYDCAAHVLTMTLNTDLHETLHGELYYAFRDLRFMPHDRGLREEWAGGDVMEGNSTGGPQSVFERRGDGRWPTLVVLGGDTEPLTEMRRDMAFWFSRSGHRVKVVVLAKFERRRRVVVVERWEEEDGRIEIVGGGLVLGFRSLFLRDPGPEEGDFVVSMPDLEEYAERVFGQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PA99</accession>
    <name>A0AAN6PA99_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_38930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854472">
        <property type="protein sequence ID" value="KAK4034623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PA99"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF2">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4034623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="287" mass="32861" checksum="10B49540936D46A6" modified="2024-10-02" version="1">MASGATNDTQLAAPAAAAFEFLHLARELRNMIYLEMMKHPPSIGDPRVHWPNYGVECQMGLATSREAITALIPFLQSCSLINNELSSLIYSQNFRLIADPSHSRFPAAQWLSTIPAHRLVRLELYIDGRRPLTDADKAVRLLPVRAPGLRDLTIRMDFLDDHEDEWSWMDPMGEEVEEWAFGVEEPTKQADSEKRFFGGRLIAVLKRMRELNLRVLRMRPVEDERWVKAVCREVGIEVEVQSSYEMDGEPDKVLYKPGGLLEEVEGFNLEDVNLDEDVEYESGWEIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PAY0</accession>
    <name>A0AAN6PAY0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cortical protein marker for cell polarity-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_19121</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854499">
        <property type="protein sequence ID" value="KAK4033997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PAY0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902929">
        <property type="term" value="C:plasma membrane of growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024982">
        <property type="entry name" value="Rax2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048266">
        <property type="entry name" value="Rax2-like_second"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048265">
        <property type="entry name" value="Rax2-like_third"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31778">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN RAX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31778:SF2">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN RAX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12768">
        <property type="entry name" value="Rax2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20842">
        <property type="entry name" value="Rax2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20843">
        <property type="entry name" value="Rax2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043046791" evidence="2">
        <location>
            <begin position="36"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1173"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="domain" description="Rax2-like second" evidence="4">
        <location>
            <begin position="237"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="Rax2-like third" evidence="5">
        <location>
            <begin position="398"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="Rax2-like C-terminal" evidence="3">
        <location>
            <begin position="915"/>
            <end position="1166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF20843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4033997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1242" mass="129529" checksum="E7DD5D82C8373E8C" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PBB7</accession>
    <name>A0AAN6PBB7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Only prolin and serin are matching in the corresponding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_19818</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854545">
        <property type="protein sequence ID" value="KAK4033216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PBB7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="311"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4033216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="548" mass="60101" checksum="DBBF07486CBE3BCC" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PBG3</accession>
    <name>A0AAN6PBG3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">CHD5-like protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">GET1</name>
        <name evidence="12" type="ORF">C8A01DRAFT_38233</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the WRB/GET1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854449">
        <property type="protein sequence ID" value="KAK4035275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PBG3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043529">
        <property type="term" value="C:GET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071816">
        <property type="term" value="P:tail-anchored membrane protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.660:FF:000006">
        <property type="entry name" value="Protein GET1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.660">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03113">
        <property type="entry name" value="Get1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028945">
        <property type="entry name" value="Get1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027538">
        <property type="entry name" value="Get1_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029012">
        <property type="entry name" value="Helix_hairpin_bin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42650:SF1">
        <property type="entry name" value="GUIDED ENTRY OF TAIL-ANCHORED PROTEINS FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42650">
        <property type="entry name" value="TAIL-ANCHORED PROTEIN INSERTION RECEPTOR WRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04420">
        <property type="entry name" value="CHD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="topological domain" description="Lumenal" evidence="9">
        <location>
            <begin position="1"/>
            <end position="4"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="158"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="9">
        <location>
            <begin position="173"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="189"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK4035275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="213" mass="24219" checksum="6B8EDA1A29F8A3F0" modified="2024-10-02" version="1">MPSLLVVIFVVELAVQLVNTIGATTINNLIWRLYLSIPTPLAKQFTDQRQKQKEYLAVRHDLNATSSQDEFAKWAKLQRQHDKLLEELKLKKSALEAARTRFDRYLTAVRLVSTRGAQWLLPMWYGKVPMFWLPYGWFPYYVEWFASFPRAPLGSVSIAVWQGACTSILTLVMNTVVGVLGLVAAGRESRRQRQKQKQPVPAGAGNGESKKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PBH8</accession>
    <name>A0AAN6PBH8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_18233</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854457">
        <property type="protein sequence ID" value="KAK4035029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PBH8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.110">
        <property type="entry name" value="acylaminoacyl peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050261">
        <property type="entry name" value="FrsA_esterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22946:SF13">
        <property type="entry name" value="ALPHA_BETA HYDROLASE PSOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22946">
        <property type="entry name" value="DIENELACTONE HYDROLASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="2">
        <location>
            <begin position="220"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4035029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="432" mass="47220" checksum="B61636E93499A60A" modified="2024-10-02" version="1">MHQFFPGIFFNFETVRILGMAPAGGAELAECLDAVGQIKDNDPESWHRAWAEQARKAEAVANEARASGDREAAKRALLRAHNYARASYYMLPGAGPLSPDPRYLTLCEKSVALFQDATKFFPPGTVHRLQIPFEGRKLPGYLYLPPSWRRLPGKQKAPILVANSGADGLSEEIYFMAPAAALELGYAAVTYEGPGQGLTLHRDGVVFRPDWEVVASAVLDHLETLSATKPELGIDTDRVAVWGTSLGGYFALRAAAGDTRFKACVAIDPVHDFWDFATTQVPKAFLAAWERGWIGDGAVDAVINLGTRLAFQMKWNIATTGTFFGQRRPSQILRAMKNYTLRLPGGVSLLDQIRCPVLVTGAEASLYLDVSSHTSAVYDGLSNLKEGDEKQLWVGTTPGEGGLQAKVGALALSNQRVFRFLDQHFGVVREHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PBP6</accession>
    <name>A0AAN6PBP6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_38093</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854444">
        <property type="protein sequence ID" value="KAK4035410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PBP6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF115">
        <property type="entry name" value="DEHYDROGENASE XPTC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042961049" description="Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein" evidence="4">
        <location>
            <begin position="22"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="5">
        <location>
            <begin position="316"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="595"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="638"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="123"/>
            <end position="126"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4035410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="690" mass="73597" checksum="1BA3F288C5A1436C" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PBZ3</accession>
    <name>A0AAN6PBZ3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Yippee/Mis18/Cereblon domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_18051</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854450">
        <property type="protein sequence ID" value="KAK4035269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PBZ3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="396"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="253"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="345"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4035269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="479" mass="52492" checksum="C6C1E5D7469D98E2" modified="2024-10-02" version="1">MKTVFCECKKCDAPIGRFANLWTQIGKSYFSPVVEPEDDLAVQCQGAVRVGERGTLVDECHLQDIACSSCGALLGLRCIQTPVNHVLDENQILLRLASVELLDSDGRDIEFSIKRVLTVNEPSKSNKAKFPDPSQGGFTSTFPGAAELQQLQIDLHSQREDIKRIDSNGFRIVSALDKRADRIQGDVTKLRGTVPGLQRDVGALQQELGSIKAEVGKAKASAQDLTALAGLEDGLASVTSTVREVGEQLAALNDQFQKEIGELRSELGQQQQEMEDLRSEVGGSVSVADHAQDLVNLRAEMAQLRRQMDETRAHESTRAHTAFPPRELEVLTSNIAKIGNRASQVETLQMELEILKGRVERAEASRQVADDRRVIRTIDPGLSGYSDMYPAMRKRAASPSLEPISKRPASSLGYPDPPDRRYATPPAWSTLPTATNREDLPESEGTAHTPNTAKRGRNLPRGRPPSMSSGISTRLRKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PCG6</accession>
    <name>A0AAN6PCG6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cerato-platanin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_48031</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854432">
        <property type="protein sequence ID" value="KAK4038328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PCG6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010829">
        <property type="entry name" value="Cerato-platanin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38850">
        <property type="entry name" value="CERATO-PLATANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38850:SF2">
        <property type="entry name" value="CERATO-PLATANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07249">
        <property type="entry name" value="Cerato-platanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042910072" description="Cerato-platanin" evidence="3">
        <location>
            <begin position="19"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4038328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="263" mass="28038" checksum="A06471168C94110B" modified="2024-10-02" version="1">MRSLHFFSLLAAATTARAAGGTVWATPHESYSSSVGVLGCKVDTNRIAYWPASVDCDNICVSLSYEGRTVHLLRIDQSQGAHDVSYDAWNYLVTGYSATERPTTGGAIAMEYQDADASACASLIHTDGNKLPLSAANSMNYLASCLSRDTWVGKNHLLYNILDPICSWGNDEVCTLDWPTANQATCPTQLGTPSVLTSTPVYNIQYVTGNKVSASNGQVVSSGGAAISPPLDLSQKSGGRIARGDTVVVMAMSLFTYWFLCGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PCP1</accession>
    <name>A0AAN6PCP1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_48180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854437">
        <property type="protein sequence ID" value="KAK4038187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PCP1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4038187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="417" mass="46714" checksum="330337FAA94621C4" modified="2024-10-02" version="1">MQPTTLNLTRETLLLQTYLTNRRLVSRFLLSGAFTDAVLSHLCTTLHAAPEMLLHVTLACASRFASRGFVPAALGGDLEGRHADAKAVKVLRGVEVQAREGRMGIREVVLVLTLGLGLVTFDLSDSGLWAHEVCRFTLGLVERGYYSSRGAIKGGIWVHQAGRVFEVDDALLPPLSMDVYNCLVRRQIPICRLEMGHDEGKRVDKYLGLCGPLLAMLFDICRLSHQLRPSGDPSQTLDAKARDEILGELDGIEDTVLEWDPQVPELFALAASPDEVRGVQGQARIYKIMTLLIIHRLRYAFGTQDDNAYELSQTILAEIEKVYARPSTPGGYVKNSTGQFDYRLSLPFFIAAIELEDPSERIRALDRLQSVVCRKIYPRVVEQLGQALKFVWEARDWQYCTHWFDLLSTGIVPFILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PCR2</accession>
    <name>A0AAN6PCR2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_17353</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854425">
        <property type="protein sequence ID" value="KAK4038559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PCR2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39608">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G08640)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39608:SF2">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4038559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="187" mass="20753" checksum="B3F583606476A8AF" modified="2024-10-02" version="1">MDTTGRGGFFSGRIARTLLGLNNLVILASSIIITGILAYFLNWGYRSVHLVYNMVIAVLTLFLYIFAVVLPVLKSYHGYMLPLNLALTYLWLTSLIFSSQDYSGNRCRSYYSTAASRCGLKHTIQAFHIIGFSFLLFNTILEALMWATHRRDRQAGTGDPEKDRPLTTTTGTTTGGADGERVAEVPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PCR8</accession>
    <name>A0AAN6PCR8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_39150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854482">
        <property type="protein sequence ID" value="KAK4034373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PCR8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018830">
        <property type="entry name" value="DUF2434"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10361">
        <property type="entry name" value="DUF2434"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="213"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="262"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="307"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="340"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="439"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="502"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="512"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4034373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="555" mass="62344" checksum="8A65CDFC6993931D" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PCV4</accession>
    <name>A0AAN6PCV4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_18123</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854453">
        <property type="protein sequence ID" value="KAK4035150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PCV4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4035150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="313" mass="35667" checksum="CE9E32A06197EC0D" modified="2024-10-02" version="1">MIDDHELRPLTRPVLSSKNESRPVLGPTNFDLVEELELRASSVEKIFDRQNKMSRRLLDSIGAYNNFQSLTPQQADRLISRLKDTCTLLDRIADCAATIRRGFELEPTPPFPGFGEVHLQRVIHRAHQRLIASLGPLDLALFELLSFPVMMEYFCMRLGLTAGDVHEHIKHLVAFKEVMLQNGTMAVYYSAFPDSHHHIFQKLAAEEEVKSRRWTAGERSVAPDWSPPGVLASLSDVASNTFSKKVRKIPKEHLDEMEKAEHNGPMESRPAKIWFIRRWLDTNDESLAHRPLIPEEPLAELFAWAVTQDPTCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PD12</accession>
    <name>A0AAN6PD12_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SPT2 chromatin protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_48508</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SPT2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854450">
        <property type="protein sequence ID" value="KAK4035240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PD12"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013256">
        <property type="entry name" value="Chromatin_SPT2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08243">
        <property type="entry name" value="SPT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00784">
        <property type="entry name" value="SPT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="19"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="373"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="160"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="247"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="278"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="301"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="333"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4035240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="392" mass="42874" checksum="2F6BA2F6483246B5" modified="2024-10-02" version="1">MAVSADAPRLLILDLLASITGEKPSPSSNLVPRPSAPLSKRKAEDEPRPAGVKLARINSFPDKSAGSNDNSPKPSPRPAHRPLDRSCANQASNPRPASDNKRALNERPSAADPKAGSAGTRPANGSKPLPSRPLANRPSPTDSGPPKKRSYAEIMARAKANSEQRESLGKIQHKTVERTLTMKERKEMKVEDARKAKMAARKSATGRPGATSAHLRDVARVSGARNNLPSASAKKTPPVEEKKVKKAALATTGYTGTARPRPGASTTAKPGAPSRPGSEARSRDRPRYGGPLSSSRRGRDEEDDLDDFIVDDEEEEEEQPGYGHARQYRYDSYEEESDMEAGISDIEDEEQLADRQARREDLEQEALEKRLKREKEERRRKFLDATKSKAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PDD3</accession>
    <name>A0AAN6PDD3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">AP-2 complex subunit MU</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_37207</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <location evidence="6">Coated pit</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the adaptor complexes medium subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854417">
        <property type="protein sequence ID" value="KAK4038882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PDD3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09251">
        <property type="entry name" value="AP-2_Mu2_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14836">
        <property type="entry name" value="AP2_Mu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000002">
        <property type="entry name" value="AP-2 complex subunit mu, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050431">
        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043532">
        <property type="entry name" value="AP2_Mu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001392">
        <property type="entry name" value="Clathrin_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043512">
        <property type="entry name" value="Mu2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005992">
        <property type="entry name" value="Clathrin_mu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00314">
        <property type="entry name" value="CLATHRINADPT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0168">Coated pit</keyword>
    <keyword evidence="2" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="8">
        <location>
            <begin position="168"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR005992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4038882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="437" mass="49156" checksum="600D227EBA4CFDFF" modified="2024-10-02" version="1">MLSGILVFNQKGENLIFRAFRNDCRPRLADVFRIQVISNAQVRSPILTLGSTTFSHVKHENIYLVAITKSNANAALVFEFLYRLIQLGRGYFGKFDEEAVKNNFVLVYELLDEIIDFGYPQNTETDTLKMYITTEGVKSERAAEDSAKITMQATGALSWRKADVKYRKNEAFVDVIEDVNLLMSATGAVLRADVTGQIIMRAYLSGTPECKFGLNDRLLLDNDGLLSLPSGNRMGSKATKAAAGSVTLEDCQFHQCVKLGKFDTDRIISFVPPDGEFELMRYRATENVNLPFKVHAIVNEVGKTKVEYSIGVRANFGSKLFATNVVVRIPTPLNTARITERCTQGKAKYEPSENNIVWKIGRFTGQSEFVLSAEAELTSMTNQKAWSRPPLSLNFSLLMFTSSGLLVRYLKVFEKSNYSSVKWVRYMTRAGSYEIRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PDK5</accession>
    <name>A0AAN6PDK5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Microbial-type PARG catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_47463</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854413">
        <property type="protein sequence ID" value="KAK4039009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PDK5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019261">
        <property type="entry name" value="PARG_cat_microbial"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35596">
        <property type="entry name" value="DUF2263 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35596:SF1">
        <property type="entry name" value="MICROBIAL-TYPE PARG CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10021">
        <property type="entry name" value="PARG_cat_microb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Microbial-type PARG catalytic" evidence="2">
        <location>
            <begin position="62"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4039009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="324" mass="35838" checksum="6A4DBA8AADC4EE25" modified="2024-10-02" version="1">MPPRPPTPGPRGPLPRRQPHREPPKQPGPPPSGQKGSSSTSQALRQAAVETRKIHGKTSYKYTLKEVTRLDSQYCPNFPQPATIRVVNDDTTNAGLSLAAAAHPAGMDWPQHDWNPLIVNFANEHVPGGGWLGGALAQEETIFYRSSLSFSLFPEQYPLADGAVYSPYVLVVRDDIASGHRLMDFRKPRALPVLGAVTVAAIRGPAIRTVDVPGRGSRARQKQVFARDSERNVTKGKMRLTLRMAAYNRHRRLVLGALGCGCWLEVLREDEFLGNWWDDVWFAVYDLKKTGNFEVFKRVLDGKTVCVSGDVKGVWGEVVEGSSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PE78</accession>
    <name>A0AAN6PE78_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Myosin-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Class I unconventional myosin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Type I myosin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">C8A01DRAFT_36699</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Type-I myosin implicated in the organization of the actin cytoskeleton. Required for proper actin cytoskeleton polarization. At the cell cortex, assembles in patch-like structures together with proteins from the actin-polymerizing machinery and promotes actin assembly. Functions as actin nucleation-promoting factor (NPF) for the Arp2/3 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Actin patch</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 18">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854403">
        <property type="protein sequence ID" value="KAK4039332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PE78"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01378">
        <property type="entry name" value="MYSc_Myo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11858">
        <property type="entry name" value="SH3_Myosin-I_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.4820:FF:000004">
        <property type="entry name" value="Myosin IE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.530:FF:000007">
        <property type="entry name" value="Myosin IE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035535">
        <property type="entry name" value="Fungal_myosin-I_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010926">
        <property type="entry name" value="Myosin_TH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036072">
        <property type="entry name" value="MYSc_Myo1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF837">
        <property type="entry name" value="MYOSIN-3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06017">
        <property type="entry name" value="Myosin_TH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51757">
        <property type="entry name" value="TH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 18" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="9 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8 23" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 18" id="KW-0505">Motor protein</keyword>
    <keyword evidence="10 18" id="KW-0518">Myosin</keyword>
    <keyword evidence="7 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 17" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="Myosin motor" evidence="21">
        <location>
            <begin position="39"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="domain" description="TH1" evidence="22">
        <location>
            <begin position="772"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="20">
        <location>
            <begin position="1064"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="18">
        <location>
            <begin position="587"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="946"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1121"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="954"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="994"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="1040"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="19">
        <location>
            <begin position="1052"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="19">
        <location>
            <begin position="1126"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="1138"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="1156"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="132"/>
            <end position="139"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00032645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KAK4039332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1215" mass="134896" checksum="AEF42CE925EAB15B" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PF58</accession>
    <name>A0AAN6PF58_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_17730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854438">
        <property type="protein sequence ID" value="KAK4038131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PF58"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4038131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="81" mass="8818" checksum="1A1D6BC10A268316" modified="2024-10-02" version="1">MPHRQSVNPVTAVHLICRALALLFELAVLTILIYMNAAEGYYTNGIRYAGVGPLPLPFLRLPKLINVMSPPPGCLCNPAQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PFJ0</accession>
    <name>A0AAN6PFJ0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Structural maintenance of chromosomes protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">C8A01DRAFT_37021</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMC family. SMC2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854412">
        <property type="protein sequence ID" value="KAK4039045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PFJ0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031981">
        <property type="term" value="C:nuclear lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03273">
        <property type="entry name" value="ABC_SMC2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1060.20:FF:000005">
        <property type="entry name" value="Structural maintenance of chromosomes 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000278">
        <property type="entry name" value="Structural maintenance of chromosomes 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000385">
        <property type="entry name" value="Structural maintenance of chromosomes 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027120">
        <property type="entry name" value="Smc2_ABC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43977">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="13">
        <location>
            <begin position="521"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="243"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="676"/>
            <end position="904"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR005719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK4039045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1179" mass="132628" checksum="7832008AF7092417" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PFQ6</accession>
    <name>A0AAN6PFQ6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MADS-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_35949</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MEF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854385">
        <property type="protein sequence ID" value="KAK4040076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PFQ6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00265">
        <property type="entry name" value="MADS_MEF2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1810.10">
        <property type="entry name" value="Transcription factor, MADS-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033896">
        <property type="entry name" value="MEF2-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002100">
        <property type="entry name" value="TF_MADSbox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036879">
        <property type="entry name" value="TF_MADSbox_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11945">
        <property type="entry name" value="MADS BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11945:SF534">
        <property type="entry name" value="MYOCYTE-SPECIFIC ENHANCER FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00319">
        <property type="entry name" value="SRF-TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00404">
        <property type="entry name" value="MADSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00432">
        <property type="entry name" value="MADS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55455">
        <property type="entry name" value="SRF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00350">
        <property type="entry name" value="MADS_BOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50066">
        <property type="entry name" value="MADS_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MADS-box" evidence="8">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="74"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="596"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="108"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="144"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="170"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="264"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="332"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="390"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="474"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="526"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="596"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="612"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4040076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="631" mass="68584" checksum="827B3E1D0D57CF0D" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PFR7</accession>
    <name>A0AAN6PFR7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_46782</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854391">
        <property type="protein sequence ID" value="KAK4039822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PFR7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="146"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4039822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="195" mass="21684" checksum="6013A65FBD8D1869" modified="2024-10-02" version="1">MADRHAPPPRASAAGVSKARNGMPSSASVRRNLFQSQLTRRPTALSPAPEDLHLDDDAQKEHHHNDQFQTQTEASFPQDDIVVRDHNGEIELGDPPTPTIDDPEDMEALEARHEDEMERERLAEAVKQHQIDRHSVLAQPEGKDPSSSCSSSMCSGRHISPELLEAVKTSLRAKVAALEEDNWLYEPGALPQRHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PG31</accession>
    <name>A0AAN6PG31_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Chromate transporter-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_16024</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854385">
        <property type="protein sequence ID" value="KAK4040067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PG31"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015109">
        <property type="term" value="F:chromate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003370">
        <property type="entry name" value="Chromate_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33567">
        <property type="entry name" value="CHROMATE ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33567:SF3">
        <property type="entry name" value="CHROMATE ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02417">
        <property type="entry name" value="Chromate_transp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="95"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="166"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="324"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="358"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="433"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="469"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="506"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="220"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="256"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4040067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="544" mass="59294" checksum="721020604359B577" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PGA6</accession>
    <name>A0AAN6PGA6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytochrome c</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">C8A01DRAFT_47723</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="12">Binds 1 heme group per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the cytochrome c family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854421">
        <property type="protein sequence ID" value="KAK4038701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PGA6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.760.10:FF:000001">
        <property type="entry name" value="Cytochrome c iso-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="entry name" value="Cytochrome c-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002327">
        <property type="entry name" value="Cyt_c_1A/1B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11961">
        <property type="entry name" value="CYTOCHROME C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00034">
        <property type="entry name" value="Cytochrom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00604">
        <property type="entry name" value="CYTCHRMECIAB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="Cytochrome c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 10 12" id="KW-0349">Heme</keyword>
    <keyword evidence="9 10 12" id="KW-0408">Iron</keyword>
    <keyword evidence="7 10 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cytochrome c" evidence="13">
        <location>
            <begin position="6"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK4038701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="108" mass="11910" checksum="CC3151811665D96C" modified="2024-10-02" version="1">MGFSAGDKKKGANLFKTRCAQCHTLEEGGGNKIGPALHGLFGRKTGAVDGYSYTDANKQKGITWNEDTLFEYLENPKKYIPGTKMAFGGLKKDKDRNDLITFLKESTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PGG9</accession>
    <name>A0AAN6PGG9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HSP20-like chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_48230</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the p23/wos2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854439">
        <property type="protein sequence ID" value="KAK4038110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PGG9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06465">
        <property type="entry name" value="p23_hB-ind1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.790:FF:000043">
        <property type="entry name" value="Hsp90 binding co-chaperone (Sba1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045250">
        <property type="entry name" value="p23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22932:SF1">
        <property type="entry name" value="CO-CHAPERONE PROTEIN DAF-41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22932">
        <property type="entry name" value="TELOMERASE-BINDING PROTEIN P23 HSP90 CO-CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="3">
        <location>
            <begin position="5"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="132"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="195"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4038110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="211" mass="23068" checksum="56EAFBA16A259E35" modified="2024-10-02" version="1">MAETKVTPEVLWAQRSSNVDPEKNFVYLTISVPDVPTANLKLDLKPTGLSFEGRSDTLKKTYHVELEFYAEIDQAESKINHTARDVEMKLRKKELGEAYWPRLLKDAKKAHFLKTDFDKWVDEDEQNEAAEDDFANFGGGGPGMGGLPGMGGGDFGGIDFSKLGGGAGMPTGDDDDEEDSDDDMPPLEGEEEGEKAEKAEDATDAKEVVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PH24</accession>
    <name>A0AAN6PH24_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">HTAFII28-like protein conserved region-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_47566</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854417">
        <property type="protein sequence ID" value="KAK4038849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PH24"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08048">
        <property type="entry name" value="HFD_TAF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045127">
        <property type="entry name" value="TAF11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006809">
        <property type="entry name" value="TAFII28_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13218:SF8">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13218">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04719">
        <property type="entry name" value="TAFII28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TAFII28-like protein" evidence="7">
        <location>
            <begin position="182"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="86"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="254"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="43"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="149"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="167"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="285"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4038849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="343" mass="36529" checksum="E602F9C5F1F16141" modified="2024-10-02" version="1">MASPSHSPPYSQTPLPGINTMSSNKKRTADGPAAPALKRRKASTISTASGAASAHPLRQTSFPPDDSSALFGARSPSVDVDTMSLVSGSQVSAAAPVKKKRGRKSKAEKAREQTPSVAGGRAPTAASGVSDGGGGRGNKSVAGGGGGGDEGEGDDEGPTEVAATADVRTKEQKEEEHRMRGMLISALSDDQFYRFENWRAANLSKASVRRLVNATISQSVAENVVIGMRAVAKVFIGDIIESARRVQGEWIERLDEKQTDLPTPPATVAPTPTADGEADTQTRNSEVDDRRGPLRPEHLREAVRRYRKGFEGGGVGMQWVYHQQQQGGVERFPTRTGGRRIFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PH37</accession>
    <name>A0AAN6PH37_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_45882</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854368">
        <property type="protein sequence ID" value="KAK4040863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PH37"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056693">
        <property type="entry name" value="DUF7791"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF5">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25053">
        <property type="entry name" value="DUF7791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="3">
        <location>
            <begin position="219"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="3">
        <location>
            <begin position="335"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7791" evidence="4">
        <location>
            <begin position="551"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="908"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="917"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="938"/>
            <end position="950"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4040863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="950" mass="108140" checksum="EFEC78AD8EF21B34" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PH82</accession>
    <name>A0AAN6PH82_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Protein-S-isoprenylcysteine O-methyltransferase</fullName>
            <ecNumber evidence="4 11">2.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">C8A01DRAFT_45851</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + S-adenosyl-L-methionine = [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:21672"/>
            <dbReference type="Rhea" id="RHEA-COMP:12125"/>
            <dbReference type="Rhea" id="RHEA-COMP:12126"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90510"/>
            <dbReference type="ChEBI" id="CHEBI:90511"/>
            <dbReference type="EC" id="2.1.1.100"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Endoplasmic reticulum membrane</location>
            <topology evidence="11">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM170 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.100" evidence="4 11"/>
    <dbReference type="EMBL" id="MU854367">
        <property type="protein sequence ID" value="KAK4040923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PH82"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004671">
        <property type="term" value="F:protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007269">
        <property type="entry name" value="ICMT_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025770">
        <property type="entry name" value="PPMT_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019334">
        <property type="entry name" value="TMEM170A/B/YPR153W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714">
        <property type="entry name" value="PROTEIN-S ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714:SF9">
        <property type="entry name" value="PROTEIN-S-ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04140">
        <property type="entry name" value="ICMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10190">
        <property type="entry name" value="Tmemb_170"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51564">
        <property type="entry name" value="SAM_ICMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="77"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="267"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK4040923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="391" mass="43138" checksum="B5E67FBA356D66EC" modified="2024-10-02" version="1">MEIPSRVRRDTPAAYTVPPFPSLFWPPQDSSIILYELDDMWKFTLFWTLILYGLFHLGAVGVAVLMQGGKRTSSWKYLWLVPLVYALIAGAEALIAGTLVGLMCVSRRCRSFSATGPGPPLSKQRTFRGFESRAPPTAASKNEPIQLANSPKSLAGIATRAFGLGIALTAGATATLTLLLCTTSPLWRLPFFLTALALFHFLEFWTTAAYNTRAAEISSFLLTANWPGYAVAHSVAALECLLTHLLWPTTNNNTRWTTTPLGLGLEGLSPAVTAAGLVLVVLGQAVRSMAMIHAGQSFNHQVQYQRRADHVLVTDGVYAVLRHPSYFGFFWWALGTQLVMGNVVSLVGYAVVLWKFFSGRIKHEEAYLVSFFGEGYVDYRRRVPTRIPFVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PHP8</accession>
    <name>A0AAN6PHP8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD binding domain-protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_36816</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854407">
        <property type="protein sequence ID" value="KAK4039194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PHP8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38663">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38663:SF1">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="299"/>
        </location>
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            <begin position="286"/>
            <end position="296"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4039194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="585" mass="64803" checksum="A74E7F2285B032E8" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PID2</accession>
    <name>A0AAN6PID2_9PEZI</name>
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        </submittedName>
    </protein>
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        <name evidence="10" type="ORF">C8A01DRAFT_36329</name>
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        <name type="scientific">Parachaetomium inaequale</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
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        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FHA_dom"/>
    </dbReference>
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        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
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        <location>
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            <end position="189"/>
        </location>
    </feature>
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        <location>
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            <end position="414"/>
        </location>
    </feature>
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        </location>
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        </source>
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        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="677" mass="72912" checksum="108747B611B0AE52" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PIG4</accession>
    <name>A0AAN6PIG4_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">C8A01DRAFT_34646</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854359">
        <property type="protein sequence ID" value="KAK4041342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <location>
            <begin position="1"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4041342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PIK0</accession>
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        <recommendedName>
            <fullName evidence="8">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_36844</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
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        </lineage>
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    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
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                <person name="Cros-Aarteil S."/>
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                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
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                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <dbReference type="EMBL" id="MU854407">
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HD"/>
    </dbReference>
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        <property type="entry name" value="Homeodomain-like_sf"/>
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        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 2" id="KW-0371">Homeobox</keyword>
    <keyword evidence="1 2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="4">
        <location>
            <begin position="618"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="5">
        <location>
            <begin position="699"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="1">
        <location>
            <begin position="620"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="464"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="900"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="964"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1005"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="464"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="520"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="588"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="910"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1021"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1035"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1054"/>
            <end position="1065"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4039220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1065" mass="119920" checksum="8928D8F6C6CB791C" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PIK6</accession>
    <name>A0AAN6PIK6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">xylan 1,4-beta-xylosidase</fullName>
            <ecNumber evidence="11">3.2.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">C8A01DRAFT_46036</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>Hydrolysis of (1-&gt;4)-beta-D-xylans, to remove successive D-xylose residues from the non-reducing termini.</text>
            <dbReference type="EC" id="3.2.1.37"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Glycan degradation; xylan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.37" evidence="11"/>
    <dbReference type="EMBL" id="MU854372">
        <property type="protein sequence ID" value="KAK4040665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PIK6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009044">
        <property type="term" value="F:xylan 1,4-beta-xylosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031222">
        <property type="term" value="P:arabinan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044993">
        <property type="entry name" value="BXL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42721:SF3">
        <property type="entry name" value="BETA-D-XYLOSIDASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42721">
        <property type="entry name" value="SUGAR HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042847854" description="xylan 1,4-beta-xylosidase" evidence="12">
        <location>
            <begin position="21"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type III-like" evidence="13">
        <location>
            <begin position="668"/>
            <end position="738"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00026107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK4040665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="759" mass="81608" checksum="8965DC038C775DEA" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PIQ1</accession>
    <name>A0AAN6PIQ1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_34580</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854358">
        <property type="protein sequence ID" value="KAK4041382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PIQ1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052355">
        <property type="entry name" value="CENP-V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28620:SF1">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28620">
        <property type="entry name" value="CENTROMERE PROTEIN V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="4">
        <location>
            <begin position="11"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="CENP-V/GFA" evidence="4">
        <location>
            <begin position="146"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4041382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="291" mass="32459" checksum="E5227B42E832FD90" modified="2024-10-02" version="1">MSDAEQPAKTYRGNCHCGAFVYEAEAPEITSASDCSCSICYKRGYLWLVPKKPLTVVKDEGKLVHYSFASKRMDHQFCGNCGTTVMATSDMFPAGVGINVRTIQRLDLWGLEVKTFNGDTFDPQYVAPQFSGDEPAPAGFEDGKTYHGSCHCGAVTTALRVKGSLEDGTYPDRIMECNCSFCRQGGFVWIYPSANQLAVQGSDNLFYYTLGNHIWRKSFCKTCGVHIGSEANPDVTDEQIAALPEAYQKHRLAHLETRPFNTRLLNEFDVKRLQPVRADGWGLQKPEYVYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PIV1</accession>
    <name>A0AAN6PIV1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_14491</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854351">
        <property type="protein sequence ID" value="KAK4041799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PIV1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4041799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="92" mass="10286" checksum="A815F56216683C76" modified="2024-10-02" version="1">MSYPHGGGGGGGESVEFCPTRTDLHWSQAQYDRVEFADFNQVQVAQYGEVKFFQQPPDSEDENLNGEGESFFFHFGCRFFGVVHGAVKRGET</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PIX3</accession>
    <name>A0AAN6PIX3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_45911</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the ubiquitin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854369">
        <property type="protein sequence ID" value="KAK4040800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PIX3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031386">
        <property type="term" value="F:protein tag activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01803">
        <property type="entry name" value="Ubl_ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000008">
        <property type="entry name" value="Ubiquitin-40S ribosomal protein S27a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002906">
        <property type="entry name" value="Ribosomal_eS31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038582">
        <property type="entry name" value="Ribosomal_eS31_euk-type_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01599">
        <property type="entry name" value="Ribosomal_S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01402">
        <property type="entry name" value="Ribosomal_S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="9">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4040800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="154" mass="17666" checksum="80686792B8AF9F32" modified="2024-10-02" version="1">MQIFVKTLTGKTITLEVESSDTIDNVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGGKKRKKKVYTTPKKIKHKRKKTKLAVLKYYKVDSDGKIERLRRECPNETCGAGVFMAAMQDRQYCGRCHLTYVFEKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PJ00</accession>
    <name>A0AAN6PJ00_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_35988</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family. Isoflavone reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854386">
        <property type="protein sequence ID" value="KAK4040021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PJ00"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF4">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="4">
        <location>
            <begin position="3"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4040021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="317" mass="35140" checksum="083254165A3000A3" modified="2024-10-02" version="1">MVKIAIAGGSGNVGQEIIDVLVATKKHEILLLSRKDAPPGETAPSVTWVKTNYEDPEQLDETLRGVDTVLSFITAHLDPGSVAQKGLIDAAVRAGVRRFAPSEWAMAKFDHMPWNDGKTEIREYLKQLNKDKKVLEYSLFVPGLFTNYLTRPYKSTKHVHPMETPIDFDQRRLLMVEGRDDARITLTTVTDIVNVVARAIDYEGEWPVVGGIRGDTLAIGEIVKLGERVRGGTFKVERLQADDLNSGVVKSSWIPRPDHPSFTPEQIEALAERLTAGILLGISVGAASVSDEWNQLLPDYKFTKAEDFLAEAWHGKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PJX1</accession>
    <name>A0AAN6PJX1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_34628</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854359">
        <property type="protein sequence ID" value="KAK4041325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PJX1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4041325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="257" mass="27066" checksum="768142C5557A7EF9" modified="2024-10-02" version="1">MVVLPGGSPVGKRVQDRQDTTPPELTVSQTIAGSSTLQIAAAALDAGSPIPSAGDAGPTRRQPQIRSASGVPEVIVVDIEPPGAGNAAGPPTHNGVYPEPPRDPGYTMSATPIAMGGPSDPYTLDGSLRVGVVRHPYAHGYTMTPEPALRAPASMPPMQHGEFETYPAGQQQHSGMQRAPRVIPAYPAGPGLFPPPTSHQRHGANGAVDTGARPRAWGEFDDDDEVSVLNKETARKRRRNQPTKSLSALFTWGSKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="4">SET domain-containing protein 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_45379</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854357">
        <property type="protein sequence ID" value="KAK4041415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PK35"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053185">
        <property type="entry name" value="SET_domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332:SF6">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042885213" evidence="2">
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            <end position="436"/>
        </location>
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        <location>
            <begin position="128"/>
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        </location>
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        <location>
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        </location>
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            <begin position="425"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4041415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="436" mass="48698" checksum="027EFE6B063ADCBF" modified="2024-10-02" version="1">MYTLPLIAGLSITGFATALTEQARNIESCSWSPLVYEDQFTCAAPLTKQRPPTLLKVETPELWNEFDERYEPPRTYQLPAPWKGPERCSTEFCLFSSPVAGEGMSLITTSRSAYIVATSKIPMSTGLEPTALYEAEIPGKGVGLIANRTIRKGEIIMQRAPALLIQSTPHLDLEPELRLEVYQAAVYRLPEVTRDRFLRQIGNNIYDKVEKNSFRIFVDGDRKHSAHLGIFPEVSKFNHDCRPNVHYRLANLTHTTVAVRDIPAGEELTISYIYGRTPRSERQSQLSEWGFTCTCSQCTLPDLESRASDIRLRQIKELEAEIERLMSRGGGGGGGMRPEMGGKLVELYLAERLDAYLAPTYTRAALIYSMFGHEEKAREYAREAAGALERETGPQATDIESMRRLAGDPKGHWSWGVMATSGKGGGERNKTEAKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PK51</accession>
    <name>A0AAN6PK51_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Erythromycin esterase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_46668</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854388">
        <property type="protein sequence ID" value="KAK4039940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PK51"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="488"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="549"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="638"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="244"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="557"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4039940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="676" mass="71942" checksum="DDA447A30910C00F" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PKC1</accession>
    <name>A0AAN6PKC1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_15517</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854373">
        <property type="protein sequence ID" value="KAK4040619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PKC1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4040619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="335" mass="36565" checksum="A1090E522334DD14" modified="2024-10-02" version="1">MSTLESQAAWAASAALIGLAVIPLSTFWGFNLCGKRSGQPSQRVKFARISLQMALPVFTLAVLLAVVSPAIIATLPTSTGRLRSSDSRVATAAVYTALTSSFTITAAGILTTVAVYLSGICVLYLVLAKQKWWKIVRLDALCGAALLLVLDIAWFAKTVSDSLNGNDDGISLAWLIVLVDITVCLLAAVVVGVAIYVAPKLKRRTDLAVGNLSSLLLSASFLWLFRCAFVLSVDLKSIIPDWTAIELSAQKILYPILDFWVSATVLGLVTFILRNPVLCDPSAIPDHPPEQQPQVYVQYVPVGFYSQPRHGQQPQMYQQYHQYYPPQPRLYQQPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PKN6</accession>
    <name>A0AAN6PKN6_9PEZI</name>
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        <recommendedName>
            <fullName evidence="4 8">Stress response protein NST1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_15848</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">May act as a negative regulator of salt tolerance.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the NST1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854381">
        <property type="protein sequence ID" value="KAK4040225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PKN6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd22249">
        <property type="entry name" value="UDM1_RNF168_RNF169-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051195">
        <property type="entry name" value="Fungal_stress_NST1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025279">
        <property type="entry name" value="NST1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31780:SF10">
        <property type="entry name" value="LD36051P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31780">
        <property type="entry name" value="STRESS RESPONSE PROTEIN NST1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13945">
        <property type="entry name" value="NST1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
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            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
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            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="560"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="942"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
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            <begin position="1208"/>
            <end position="1258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="119"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="151"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
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        <location>
            <begin position="330"/>
            <end position="373"/>
        </location>
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            <end position="478"/>
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            <end position="515"/>
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    </feature>
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        </location>
    </feature>
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        </location>
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        <location>
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        </location>
    </feature>
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            <end position="867"/>
        </location>
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        <location>
            <begin position="979"/>
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        </location>
    </feature>
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        <location>
            <begin position="1014"/>
            <end position="1028"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU049441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4040225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1258" mass="137952" checksum="DD6D724292087674" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PKT4</accession>
    <name>A0AAN6PKT4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_33122</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854336">
        <property type="protein sequence ID" value="KAK4042731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PKT4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4042731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="504" mass="56316" checksum="478AC1617952C42A" modified="2024-10-02" version="1">MGDTADGQDGDPADSASKLGFEVVDIVPDGDVVLDVTFETSKETLRAARKAAKPRPGQKEAAPVFKPRTRVGYRVELAVLKQNSKYFDNLLSDTRFAEARAIEASFEKLSLKNVKPSEADAAELPVVRIHEDDEATRSAGQDSAFEDLLRILHRKQSTSKAVTMHYLAVLAVLADRFDCIAIVSRYLNALKYKWPATQTRLARDDGPALSRATEETLRQKILVSWLLDQPPKLHAATRELIMYGSRRWSAFLDEDDDDHNAAAWWDLPDDLERELHNRRESILATIASIPRHFLSLYTSRTRQCKLGYDSSASCDSYQLGEMLKFLSSRNLLFLSDFSSPYSPYSPHSSTHSHSHPPPMQDADLDFATTDIGQILATLKQCPSYQIDKNHTNCGLRTRVLPALEHVQAMLAAGAVSISRQAWVKDREGASWFLQNGDGGEGKKATKKVFRFTRGLATDQRLRVEGAMVAERMARGLFTAGEWDWTAEDEEGGRGVEFGRWPAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PL07</accession>
    <name>A0AAN6PL07_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_44033</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854333">
        <property type="protein sequence ID" value="KAK4042963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PL07"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4042963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="136" mass="15849" checksum="C89F8E9D78385238" modified="2024-10-02" version="1">MDVRALVNNNNIHASPCAQRFYQLQLRQQAYDTVYRGPVFRGLRHSTPLTRDQKLEIRTLRNHAKWDYMTIAQATGKTFHQVQDALTGPLTPKRNRCGCKPLLKTPEKNALVQFLHSDPMNRKLPWADLRYYIPGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PL79</accession>
    <name>A0AAN6PL79_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Serine esterase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_44198</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the putative lipase ROG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854335">
        <property type="protein sequence ID" value="KAK4042842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PL79"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007751">
        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044294">
        <property type="entry name" value="Lipase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482:SF62">
        <property type="entry name" value="LIPASE ROG1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482">
        <property type="entry name" value="LIPASE ROG1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF676" evidence="4">
        <location>
            <begin position="264"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="DUF676" evidence="4">
        <location>
            <begin position="364"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="DUF676" evidence="4">
        <location>
            <begin position="455"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="172"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="237"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="302"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="645"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="699"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="759"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="824"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="984"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="305"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="321"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="353"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="706"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="759"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="840"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="878"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="985"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1010"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1037"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1048"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1090"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="1128"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="1156"/>
            <end position="1175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4042842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1182" mass="127023" checksum="A566F0E8DCC2E9BF" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PLD3</accession>
    <name>A0AAN6PLD3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_32678</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854330">
        <property type="protein sequence ID" value="KAK4043188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PLD3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="160"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="599"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="703"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="712"/>
            <end position="728"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4043188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="742" mass="79790" checksum="677CBAB6DB0E02B2" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PM09</accession>
    <name>A0AAN6PM09_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_13167</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854329">
        <property type="protein sequence ID" value="KAK4043292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PM09"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="458"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="150"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="215"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4043292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="479" mass="51168" checksum="0A71A4BAC50B7966" modified="2024-10-02" version="1">MDPSGATGGPSQAQQAQPRPRKRARTARVSEAGNAAPVAQAAAQGWGPATVANGHHHSQTVRAPVDTVPTHHAPTFPSQQLDRSHQVAEPDGLMNRYGTGPQHSQYPEQQPTLAPAPQPDTSGLTSLSALAGDHQHHQHAQHGQQHHQAQHQQLQHQQQRGAGNKPDRIVFQPQYGAPHPTSNPSPTAVANPASASAGYNIPPWTVPDPNPAPQQQPSAPSSSSMPPQSPALGSSAGLAPPPEGIYRSFDDLLSAVQRTAKEQGYSIVKLRASNYRDGKPTRYDLVCDRGGVKYSSTAKKRNPSTRKVDCPWRAKAVCEVNLGHQWRFAVQEARHNHEARVPAAVPGQENTPVAQSLRSLTNKVDRMAHDVAQGFNRLENAFSARLDNIEKRLENLETARSTMLGGNGVPQMGGPSMPPANMGGSSLGNGSLANGGMQPLVDGRLGGVESRLSHMEPRSLDGLPMMDDDTRGLSMMVNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PMC3</accession>
    <name>A0AAN6PMC3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_32548</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854328">
        <property type="protein sequence ID" value="KAK4043422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PMC3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34286">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34286:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4043422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="92" mass="10368" checksum="F06DC8A387532D62" modified="2024-10-02" version="1">MGGGGKIPYPKHVWSPAGGWYAQPANWKANTAVFGVVIFGITALVWKLSADREYRHKMPEQGRFYPSRNWSKQIIAHDQAQEKAALEKPQES</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PME1</accession>
    <name>A0AAN6PME1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Prolyl 4-hydroxylase 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_32046</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854324">
        <property type="protein sequence ID" value="KAK4043728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PME1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004656">
        <property type="term" value="F:procollagen-proline 4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.620:FF:000021">
        <property type="entry name" value="WGS project CABT00000000 data, contig 2.8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF236">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="7">
        <location>
            <begin position="126"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4043728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="243" mass="26929" checksum="674F7341AF55328C" modified="2024-10-02" version="1">MAKDKRSKAHPPAASSSATAATPSWPPFKPPLPVVDLTLEPLIEDKVVVLRSFFPRSLCRDYVSFLRGLPLITTPGKPKRGDAVRVNDRYQIDDATFANRLWTETGLKEAVAGEDVAHLWGGQVVGLNPNIRIYRYSPGQFFDAHYDDFNYVSLKTEAGAALPARTTWTLLLYLTSSADGCIGGETVFHPYDNNFSAKDEIAVSLETGMLLLHKHGDDCLLHEGREVTAGEKWVIRTDLCVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PMK1</accession>
    <name>A0AAN6PMK1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acyl CoA binding protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_32307</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854326">
        <property type="protein sequence ID" value="KAK4043577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PMK1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000582">
        <property type="entry name" value="Acyl-CoA-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035984">
        <property type="entry name" value="Acyl-CoA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310">
        <property type="entry name" value="ACYL-COA-BINDING PROTEIN, ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310:SF133">
        <property type="entry name" value="COA BINDING PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12300)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00887">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47027">
        <property type="entry name" value="Acyl-CoA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51228">
        <property type="entry name" value="ACB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="257"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="ACB" evidence="4">
        <location>
            <begin position="5"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="49"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="133"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="55"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="145"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4043577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="313" mass="35116" checksum="2E827DD77F5505F5" modified="2024-10-02" version="1">MSDSIDRVFVHALNTVKKIPKTGAARPPPTDRMRLYGLYKQAMEGDVDGVMERPSSSSATTGAGGTSTTSSEELVREQDKWDAWNSQKGLSRTEAKRRYVEALIETMHRYANTPNALELVAELEFVWNQVKSNSPSAAGSASEQSGGGVVAEQRSGGGGGIIASPVARRFQTPMSGSEGPMKVLSPMSEEDESERRLAELADQAEDDPGEYARRHDKRSKRMERAIVRLSAEIAALREQIATGRDWRVRKERGVFAWVGWVFWAVTKHITVDIALLLLLLLWMRKRKDRRFEDNVRAIFRLAREYVRKILPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PMQ3</accession>
    <name>A0AAN6PMQ3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">amidophosphoribosyltransferase</fullName>
            <ecNumber evidence="3">2.4.2.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_44338</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.14" evidence="3"/>
    <dbReference type="EMBL" id="MU854337">
        <property type="protein sequence ID" value="KAK4042718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PMQ3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004044">
        <property type="term" value="F:amidophosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00715">
        <property type="entry name" value="GPATase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01931">
        <property type="entry name" value="PurF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005854">
        <property type="entry name" value="PurF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035584">
        <property type="entry name" value="PurF_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01134">
        <property type="entry name" value="purF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11907">
        <property type="entry name" value="AMIDOPHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13522">
        <property type="entry name" value="GATase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="9">
        <location>
            <begin position="2"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="492"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="545"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="510"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="545"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="573"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4042718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="595" mass="63605" checksum="B3E7A8468BFB1A8C" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PMV5</accession>
    <name>A0AAN6PMV5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="19">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">C8A01DRAFT_31856</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13 19">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38567"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:38568"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66132"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:66133"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 18">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">trans-Golgi network membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="19">Membrane</location>
            <topology evidence="19">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="19"/>
    <dbReference type="EMBL" id="MU854322">
        <property type="protein sequence ID" value="KAK4043983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006892">
        <property type="term" value="P:post-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02073">
        <property type="entry name" value="P-type_ATPase_APLT_Dnf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000026">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000047">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000010">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
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        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
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        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF150">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 17 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 18 19" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 17 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 19" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="493"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="546"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1058"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1098"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1141"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1178"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1206"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1245"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="22">
        <location>
            <begin position="229"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="21">
        <location>
            <begin position="323"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="23">
        <location>
            <begin position="1027"/>
            <end position="1278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="20">
        <location>
            <begin position="69"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="81"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="16">
        <location>
            <position position="610"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="610"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="610"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="611"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="612"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="612"/>
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        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="703"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
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        <location>
            <position position="744"/>
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        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="767"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
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        <location>
            <position position="800"/>
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        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="881"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="882"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
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        <location>
            <position position="883"/>
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        <ligand>
            <name>ATP</name>
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        </ligand>
    </feature>
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        <location>
            <position position="974"/>
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        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
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        <location>
            <position position="980"/>
        </location>
        <ligand>
            <name>ATP</name>
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        </ligand>
    </feature>
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        <location>
            <position position="1001"/>
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        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
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        <location>
            <position position="1004"/>
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        <ligand>
            <name>ATP</name>
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        <ligand>
            <name>ATP</name>
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        <ligand>
            <name>Mg(2+)</name>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008109"/>
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    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00034036"/>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00051303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-2"/>
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    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-3"/>
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    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU362033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KAK4043983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1355" mass="150731" checksum="96501BA7B47392AB" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PNQ4</accession>
    <name>A0AAN6PNQ4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphatidylinositol-specific phospholipase C X domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_14138</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854344">
        <property type="protein sequence ID" value="KAK4042196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PNQ4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08586">
        <property type="entry name" value="PI-PLCc_BcPLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF113">
        <property type="entry name" value="SI:DKEY-266F7.9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphatidylinositol-specific phospholipase C X" evidence="1">
        <location>
            <begin position="165"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4042196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="502" mass="54685" checksum="87ADF903A92D6865" modified="2024-10-02" version="1">MGFVFSRPAAAAALPTAHPTLTIRNLTITPLELKQVEHLDSRRHSHEPDAPLPLAAAAKHEEEQPPSAKHDIAGVILQPFSECHTPVYMPDSARHEQLRLTFEDPSTGHLYSAEIPGPSRRSIVLQAHPKDGEAETKEFTAIYLPQHAYLALFSSANLSSWMSTLDPSLPLSALSIPGTHNSPTCHVALPSVRCQAVPILDQLNNGVRFLDVRVSCPVYTPPSNPEKPPAPAPELALVHSAFPISLTGPKYLSALLTTLHHFLATHPSETLLLSLKREGTGRGTDADLSHILHTHYIRPHREKWYTNPTIPTLAQARGRIILVRRFRLDNNSSSSAPIPPLDAAEMGIDGSIWPDNVADGTCGSGTIRIQDYYGVNSGVEIQQKVRFAQEGLERAAQGVHACTAGEVPRGGPEMPPPLFINFLSASNFFNASCWPDRIAVKINPSMIEYLCMGHGAPVKGPGELDIGDAATGIVVTDWVGHHGDWDLVRCIVGWNARLQLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PNR9</accession>
    <name>A0AAN6PNR9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">D-arabinono-1,4-lactone oxidase</fullName>
            <shortName evidence="9">ALO</shortName>
            <ecNumber evidence="4 9">1.1.3.37</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">L-galactono-gamma-lactone oxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">C8A01DRAFT_13902</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-arabinono-1,4-lactone + O2 = dehydro-D-arabinono-1,4-lactone + H2O2 + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23756"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:16292"/>
            <dbReference type="ChEBI" id="CHEBI:58277"/>
            <dbReference type="EC" id="1.1.3.37"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Cofactor biosynthesis; D-erythroascorbate biosynthesis; dehydro-D-arabinono-1,4-lactone from D-arabinose: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.3.37" evidence="4 9"/>
    <dbReference type="EMBL" id="MU854340">
        <property type="protein sequence ID" value="KAK4042509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PNR9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003885">
        <property type="term" value="F:D-arabinono-1,4-lactone oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007173">
        <property type="entry name" value="ALO_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010031">
        <property type="entry name" value="FAD_lactone_oxidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006093">
        <property type="entry name" value="Oxy_OxRdtase_FAD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030654">
        <property type="entry name" value="Sugar_lactone_oxidase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01678">
        <property type="entry name" value="FAD_lactone_ox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43762:SF1">
        <property type="entry name" value="D-ARABINONO-1,4-LACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43762">
        <property type="entry name" value="L-GULONOLACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04030">
        <property type="entry name" value="ALO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000136">
        <property type="entry name" value="LGO_GLO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00862">
        <property type="entry name" value="OX2_COVAL_FAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0274">FAD</keyword>
    <keyword evidence="5 9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="10">
        <location>
            <begin position="44"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK4042509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="552" mass="61605" checksum="E968B52B3E5C65DB" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PNS3</accession>
    <name>A0AAN6PNS3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RGS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_44747</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854344">
        <property type="protein sequence ID" value="KAK4042226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PNS3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052246">
        <property type="entry name" value="Cell_Polariz_PKAAnc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13155:SF1">
        <property type="entry name" value="A-KINASE ANCHOR PROTEIN 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13155">
        <property type="entry name" value="A-KINASE ANCHOR PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="252"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="337"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="3">
        <location>
            <begin position="156"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4042226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="363" mass="41144" checksum="4A1D02C18FE76239" modified="2024-10-02" version="1">MDDHAAASPSPQPDYTRNRLPTLFEVLSRRTLPPVDLFSFYIYMRDQQRSVDYLDFWLDVAQHMSLCRHYVRELRRSVLVGTPDPDRSSKRSSGILEGLGELSHAVAGPSMYATEKEKDQDAQMSAFLREDRDHHDSPGSSDARQNRPSTNISTPREFNTDSNSPPHTVARQDIRASAEKILYTFLLPGAEREITLPGSITQDVTTAIEELGRDDPEVFDVAKDYVFQAMERDAFPGFLRMKALGNLIPPTLIMRLILGLVSMFGGFWAAFILIFLNEARMVRLWLILPFTIGVYCLASYQYSLDPVLALIGFSEYTPFNFSRVREPYVRKLLARRAIMVLTVTVLVDAALCVLFILVPGKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PNT3</accession>
    <name>A0AAN6PNT3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_31775</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854321">
        <property type="protein sequence ID" value="KAK4044172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PNT3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4044172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="203" mass="22176" checksum="AFF1B4970BB557F0" modified="2024-10-02" version="1">MLICVIFTQGQGRPNITRRRRVDARVVEALRSLGVSIRKRDVQIELTNLVDEATALAQRVARAPGRDVERSEFVLELQQHNRLGRLLSLDQFEQFFYDDRARQPVEDPAAHCHLAPAVDAFEAAAWFWSTPEAFLEDDQTRTAQPPRQLLTTFAAFAAGPAAGPTSVAAANDPAYVSLAAGVDAMDLDDDVAGAVGSEMEVDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PP23</accession>
    <name>A0AAN6PP23_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GMC oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_31624</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854320">
        <property type="protein sequence ID" value="KAK4044307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PP23"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF138">
        <property type="entry name" value="DEHYDROGENASE PKFF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043029463" evidence="4">
        <location>
            <begin position="25"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="5">
        <location>
            <begin position="38"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase C-terminal" evidence="6">
        <location>
            <begin position="461"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="590"/>
            <end position="591"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4044307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="611" mass="65782" checksum="EC41010B04C1C1A9" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PPF1</accession>
    <name>A0AAN6PPF1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_30982</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854316">
        <property type="protein sequence ID" value="KAK4044799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PPF1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050085">
        <property type="term" value="F:mannitol 2-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019594">
        <property type="term" value="P:mannitol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000090">
        <property type="entry name" value="NADP-dependent mannitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF13">
        <property type="entry name" value="L-XYLULOSE REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4044799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="293" mass="31102" checksum="BC9747E57FB5725C" modified="2024-10-02" version="1">MADMQDGKFAHDATVAPEASRVLPLFSLKGKTAIVSGASAGIGLGVAESLAEAGANVAIWYNTRKDEAEQAAAEIEKEYGVKCQAYQVNVTSYDAVAAAIDSIARAFNGRLDVFVANSGVAWTKGPMLDGPIDMYSNVVKTNVDGTYFCARAAGLHFRRQKREGTDLNGNPLEPRFTTGSFIATASMSGHIVNVPQLQASYNASKAAVVHLCRSLAVEWAGFARANSVSPGYIRTSISEFCDADTKRAWKDKIPVGREGEVSELKGAYLYLASDASSYTTGTDINVDGGYCAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PQF2</accession>
    <name>A0AAN6PQF2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Ergosterol biosynthetic protein 28</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">C8A01DRAFT_12445</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERG28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854321">
        <property type="protein sequence ID" value="KAK4044083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PQF2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005352">
        <property type="entry name" value="Erg28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15451:SF19">
        <property type="entry name" value="ERGOSTEROL BIOSYNTHETIC PROTEIN 28 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15451">
        <property type="entry name" value="ERGOSTEROL BIOSYNTHETIC PROTEIN 28-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03694">
        <property type="entry name" value="Erg28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="8" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="11" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="122"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="151"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK4044083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="173" mass="19498" checksum="95D0E239ADA62131" modified="2024-10-02" version="1">MDKLQAFLPSAEKGYLPYYLFVVSVVAMGNALQNYATLHYTRRIYNGRFVANHGLPPATKGYNPEDSTRIVKPASSTGKDAEKARDQVSPLAARLFGAYTFMAGIIRFYACYQLENPAMYQLAIWTHVIAAIHFTTEMLAFKTIRFSGPQVFPFVAGYGGAIWMLMQYNHYVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SKW5</accession>
    <name>A0AAN6SKW5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6536 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_21375</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854828">
        <property type="protein sequence ID" value="KAK4031394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SKW5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046623">
        <property type="entry name" value="DUF6536"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35395">
        <property type="entry name" value="DUF6536 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35395:SF1">
        <property type="entry name" value="DUF6536 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20163">
        <property type="entry name" value="DUF6536"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="363"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="414"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="484"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="531"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6536" evidence="2">
        <location>
            <begin position="21"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4031394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="643" mass="66774" checksum="1F2561D938CB8DE8" modified="2024-10-02" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SLV9</accession>
    <name>A0AAN6SLV9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_20779</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854648">
        <property type="protein sequence ID" value="KAK4032113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SLV9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF147">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G01950)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="7">
        <location>
            <begin position="27"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4032113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="437" mass="48134" checksum="4E200FC3AABEE7F6" modified="2024-10-02" version="1">MADGEGAPSASASANAAGQDSGNKLVIVIVGAGLGGLLAAIGLALDGHRITILEQAASFGEVGAGMRIPPNCFKILRRWGVNTTYLKKTHSNGNRFVRYDNGALLADMPHGVPELDFGGSYLMVHRADYHTVLLERALELGVVIRAGNRVEDYDWDVPAAILQGGETVRGDLVVVADGAQSSARAEFQGHELPPTDTGDIVYRILIPAHELLSDPEMRDLISQPWVTSWCGPEAHVIGYPVRGGEVYNVVFCCSKTSMQDRPFQPGENKLVISDNSELLRRFAGWESRVQKLIALSGKDFLKWRLYDLDLVDNWVHRSGKAVLLGDAVHPMLPYMSSGAAMACEDAAVLRKMLSGTTRQSLAGRLHKYHALRQPRASKVQKAGRVLQEAYHLPDGEGQRERDIWITKDDEKNPIYWGHKERRDWLFGHDAEDIQVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SMA9</accession>
    <name>A0AAN6SMA9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PI31 proteasome regulator N-terminal-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_20107</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome inhibitor PI31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854567">
        <property type="protein sequence ID" value="KAK4032879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SMA9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004866">
        <property type="term" value="F:endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1000.30:FF:000006">
        <property type="entry name" value="Chromosome 8, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1000.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045128">
        <property type="entry name" value="PI31-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021625">
        <property type="entry name" value="PI31_Prot_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13266">
        <property type="entry name" value="PROTEASOME INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13266:SF1">
        <property type="entry name" value="PROTEASOME INHIBITOR PI31 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11566">
        <property type="entry name" value="PI31_Prot_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PI31 proteasome regulator N-terminal" evidence="4">
        <location>
            <begin position="28"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="190"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF11566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4032879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="216" mass="23801" checksum="C7D6BFF085149C96" modified="2024-10-02" version="1" fragment="single">MVLTDPLGPAAVLRAMADALPTHDKGDTTSDLSSSLDCVALFVHACMVNLGFRLLGFNEDQRIEAECARLAPRLPSQWNNSLSSHGFIYAHTQSSMQFVLHIDRLGSKIEVRGLGTGAERIARFDITARDYISSSALPLRITLTADGTEDRSDLAQKLKTLFISEERIKDLSSLLKISLIQRLLPSLQKEGYTESESAPRRTSPPPQQQPHEPAHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SMX5</accession>
    <name>A0AAN6SMX5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pectin lyase fold/virulence factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_39227</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the polysaccharide lyase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854485">
        <property type="protein sequence ID" value="KAK4034301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SMX5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030570">
        <property type="term" value="F:pectate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002022">
        <property type="entry name" value="Pec_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045032">
        <property type="entry name" value="PEL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31683">
        <property type="entry name" value="PECTATE LYASE 18-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31683:SF18">
        <property type="entry name" value="PECTATE LYASE 21-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00544">
        <property type="entry name" value="Pectate_lyase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00656">
        <property type="entry name" value="Amb_all"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 4 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042939299" evidence="5">
        <location>
            <begin position="22"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="Pectate lyase" evidence="6">
        <location>
            <begin position="45"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4034301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="323" mass="35484" checksum="674BDE014405DE42" modified="2024-10-02" version="1">MHLTGTFGSALLLAAFAPVDAQTCANCDVEAHGFASLNGGTTGGKGGRIVTAKKLDDLIRYAASTEPLIIRVDGMIKAKPFGFEVPVKSHKTIIGVGAESGIEEGGLNINSQKNVIIRNLKIHGTYDKMNWAGKEGDYDAIQVDNSTNIWIDGNHLSEMGDGLIDLRRDTDYVTVSKNRIEKHNKAFGIGWTPNVITKVTINDNFFHSTNVRNPSGDGIKYGHLYNNYYRNITGYGNYARGNSELLIETSYFEQVFDPIVAGPHGRIKTNWVKFKKCDGEIHLDVRGDTVFQASDFYNYTLADPYDIPVDIPYKAGPKADIGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SN49</accession>
    <name>A0AAN6SN49_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="15">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">C8A01DRAFT_49097</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Membrane</location>
            <topology evidence="15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="15"/>
    <dbReference type="EMBL" id="MU854476">
        <property type="protein sequence ID" value="KAK4034511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SN49"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02081">
        <property type="entry name" value="P-type_ATPase_Ca_PMCA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000002">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000039">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000028">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000193">
        <property type="entry name" value="Plasma membrane calcium-transporting ATPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006408">
        <property type="entry name" value="P-type_ATPase_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01517">
        <property type="entry name" value="ATPase-IIB_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093:SF369">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 15" id="KW-0106">Calcium</keyword>
    <keyword evidence="3 15" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="12 15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="341"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="382"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="850"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="877"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="995"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1026"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="19">
        <location>
            <begin position="99"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="17">
        <location>
            <begin position="205"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase C-terminal" evidence="18">
        <location>
            <begin position="877"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="78"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1077"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1168"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="81"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="1084"/>
            <end position="1097"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048694"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU361146"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00689"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00690"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK4034511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1198" mass="128812" checksum="6D9D4CC8EA12C93F" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SNT5</accession>
    <name>A0AAN6SNT5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carnosine N-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_48513</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854450">
        <property type="protein sequence ID" value="KAK4035246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CARME"/>
    </dbReference>
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        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12303:SF13">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12303">
        <property type="entry name" value="CARNOSINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07942">
        <property type="entry name" value="CARME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01296">
        <property type="entry name" value="N2227"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042987089" evidence="1">
        <location>
            <begin position="22"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4035246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="465" mass="52237" checksum="A921E80F01AFBCD2" modified="2024-10-02" version="1">MRSITWTVATLCWLWAGRALGDEASSATRGEPASQPGLVWVDASDPQYLVYEVRQVELALPENEHPLKRANAERHLKEKERLLQRLDRKHGTWNEHHAQHRLLEALRGFSAYAETQQAELNRLKGLYSHVPKKQKTLLEREVKYSQKFTDIAQLIEKNQQLCNGIVQNAMEFYGIGQHELDQHIRSMKSAGRGAERVSVSQALKHFVRDWAASGVNERDAAFPCILKVLKDLFPNPGQEGVKVLLPGAGLGRLGHEVAELPGFQVTNNEWSTYQNIAYRFLTSRSPNPNTSTIHPFIDSWSHHRSTADMLRAITFPDIPLDPSSVLLVEGDFTTVFRDEAAASYDVIVTHFFIDTARNLMSYFDTIARLLKPGGYWVNFGPLLYGTAPFVQLTLEEIVTVVEGMGFEFLEVAAPGSEGGSHSQGCGGKEAIPGKRVYGVEAEYGFDERALTRNAYEAVFWVARRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SPP9</accession>
    <name>A0AAN6SPP9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_48739</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854459">
        <property type="protein sequence ID" value="KAK4034965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SPP9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046536">
        <property type="entry name" value="DUF6601"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34414">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34414:SF1">
        <property type="entry name" value="SUBTILISIN-LIKE SERINE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20246">
        <property type="entry name" value="DUF6601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="293"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4034965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="353" mass="40316" checksum="05F063FF0974F33A" modified="2024-10-02" version="1">MSAVITAEIHDTVTSYRVDDDLHAPHSTPPLDLIEQELEPKRLHRRMRFLWLAGRPVPPRPLHHQLLLGREIFVSERVDLHLVWGGGRIFVKPLPRYLMNPDFWSGHLTCRCHAPAAKHMQAEHELSETGPLCSPQESGDMEPLCDRRRLRRCAMGFLLSYVALVAHESDFRIAAEKGLIPSQVQWPCWRKFVREVLHKSQENMWSEVADRFIYGELRLNRLNLIEVVLRGPFSRGYLAQWTSFGSFYRYSSALIIAGTAYILLILSAMQVGLGTTRLGEDETFQAASYGFTVFSILGPLGAVLGFLIIFAASLLYNMLRTKRFEARRARRLGRSWGSKRNMQEEGTTKAGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SPS6</accession>
    <name>A0AAN6SPS6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosomal protein L10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_18150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854454">
        <property type="protein sequence ID" value="KAK4035128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SPS6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_uL10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047865">
        <property type="entry name" value="Ribosomal_uL10_bac_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11560">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="Ribosomal protein L10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="330"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4035128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="355" mass="37691" checksum="70D0C81DD0CFE8CF" modified="2024-10-02" version="1">MPPRLRCAVPRGLGSAVSSSRTANRSAVLLLPSAPAAVAAPRQYATAAAKVSSFRLPADYVPPTKPPTARPSDTRKSQLLRTYTSLLRSTPLILIFQHNNLTAVEWAAVRRELRIALGNVSSEGTDSADVASRAQLQVIRTRIFDVALKIVEFHDPSKVAPTTTSALSGEKIQVVYDHDLSKAAYKAVQAATKGDAPLPESSAYGQISPLLVGPLAILTLPAVSPAHLAAALSVLSPSPPAFPAPSKKKNPGYHDLVAQSGFQKLMLVGGRIEDKVFDLEGVKWVGGIDGGLDALRAQLVYMLQSAGLGLTSALEGASKSLWLTMESRRSVLEEEQNGGKEGEKKEEGETKEESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SPU1</accession>
    <name>A0AAN6SPU1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_38435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854455">
        <property type="protein sequence ID" value="KAK4035100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SPU1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4035100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="256" mass="27703" checksum="17DD1E4AB6E76D48" modified="2024-10-02" version="1">MAWNPAPGFAFPPPPPPPPAGHTAPYQHPYPHHQPHHPYQQQPYQLPPQQPYQQPYQPPPIHPQPATSPYTQISYPYIPTAKRQMTLLSPDRSHPLLTVIYPSSWSTTPQLTVHRGGGPDGPEIGGALFHSFTTGKVDAYLSGVGDYRFRKKFVSLTGLGGAGGQGGRMEWGVENKTLVLSSGDGGGYVARFVLRDGADAGKATSRVEGTLVVMRGGLTDAQFGEVVVTMVAEMERKRRDNEDFKIAGAVIDVGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SPY1</accession>
    <name>A0AAN6SPY1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Eukaryotic translation initiation factor 2 subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_37789</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-2-beta/eIF-5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854434">
        <property type="protein sequence ID" value="KAK4038272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SPY1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005850">
        <property type="term" value="C:eukaryotic translation initiation factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.170:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045196">
        <property type="entry name" value="IF2/IF5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012314">
        <property type="entry name" value="Pept_M12B_GON-ADAMTSs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002735">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016189">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016190">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_Zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001:SF3">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01873">
        <property type="entry name" value="eIF-5_eIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00653">
        <property type="entry name" value="eIF2B_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100966">
        <property type="entry name" value="Translation initiation factor 2 beta, aIF2beta, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75689">
        <property type="entry name" value="Zinc-binding domain of translation initiation factor 2 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51046">
        <property type="entry name" value="GON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GON" evidence="6">
        <location>
            <begin position="230"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="34"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4038272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="339" mass="36933" checksum="F71254F87E00FCDD" modified="2024-10-02" version="1">MSTEEPIQRRPSRKSVAFTEEKLVVDADGSVTMIATDNDDTKDTAMSHTPRTPPLSAALGAFTDASSAPADGAADGAAPAADLNPDGLDLSLMKKKKKKVKKDDEEGADGAAAAAGEEAIDLSMKKKKKKKAPKEEDEFAKKLEALNLEGGEGAEAPADENVQDGDMDKGTGIWAHDESRTINYDPLLSRFFALLAQKNPDHASSGTRSYKIPPPQCLREGNKKTIFANLPEICKRMKRADEHVTAYLFAELGTSGSVDGSRRLVIKGRFQQKQIENVLRTYIIEYVTCKTCRSPNTELSKGENRLYFITCNSCGSRRSVQAIKTGFSAQVGKRRKMKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SQ12</accession>
    <name>A0AAN6SQ12_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">fructose-2,6-bisphosphate 2-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.46</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_38227</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the phosphoglycerate mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.46" evidence="2"/>
    <dbReference type="EMBL" id="MU854448">
        <property type="protein sequence ID" value="KAK4035325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SQ12"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003873">
        <property type="term" value="F:6-phosphofructo-2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004331">
        <property type="term" value="F:fructose-2,6-bisphosphate 2-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006003">
        <property type="term" value="P:fructose 2,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1240:FF:000005">
        <property type="entry name" value="GpmB, Fructose-2,6-bisphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000644">
        <property type="entry name" value="GpmB, Fructose-2,6-bisphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003094">
        <property type="entry name" value="6Pfruct_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013079">
        <property type="entry name" value="6Phosfructo_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606:SF44">
        <property type="entry name" value="6-PHOSPHOFRUCTO 2-KINASE_FRUCTOSE 2,6-BISPHOSPHATASE LONG FORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01591">
        <property type="entry name" value="6PF2K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000709">
        <property type="entry name" value="6PFK_2-Ptase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00991">
        <property type="entry name" value="6PFRUCTKNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphofructo-2-kinase" evidence="6">
        <location>
            <begin position="13"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4035325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="443" mass="50915" checksum="4D8E356D5CCF3E9F" modified="2024-10-02" version="1">MAPKINGLGVMPEDTRICVVMVGLPARGKSYIAQRAQRYLKWLSVPAATFNVGNYRRANAPHPSANFFDTSNPEGERQRRAAADAAVADMLKWFKSGGVVAILDATNSTKERRKWVLERITKEGIEVLFVESKCDDEELIMANIRDVKTTSPDYVGQDPEEAALDFRERIRNYEKVYKSIDDDKDEDHLTYLKIMNVGKKVFINRIQDYLQSRVVYFLMNLHIRPRSVWLSRHGESMFNLDGRIGGDAALSPRGEEYALRLPDLVRESVGSDRPLTVWTSTLKRTIDTARHLPKHYNQLQWKALDELDAGVCDGMTYQEIHDQYPEDFQARDEDKYNYRYRGGESYRDVVIRLEPIIMELERSEDILIISHQAVIRCIYAYFMQKTQEESPWVPVPLHTLMKLTPRAYTTELQKYSANIKAVSTWRGKGSTAKHEDPTPEGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SQS0</accession>
    <name>A0AAN6SQS0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_46964</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854396">
        <property type="protein sequence ID" value="KAK4039634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SQS0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF37">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4039634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="452" mass="52109" checksum="4262B7A20E08239F" modified="2024-10-02" version="1">MDFDENLELLAEHRYLQWLDLLQTRQVQIPEWATSFHPQRLSCSIVLPTLYGSYNFGIPVAFSNGEEWFVRFPLRGKTSAEHLDEKVASEVAALKLLRAHTDIPVPEVKAWGLARENKLGVGPFIIEEFIHGERLEPILSNPDDKDSCLLDGKLDDGKVNTIYKQLARFQLQLFNLNFEHIGSLVGGSSRLQPPLTMAANMMACLSGANVLAPLRQELSTTEDYFEHVWNQYWQQFATQRRSCAKDPVADGKANYIFHQVLKTLIKRHVWPEYSKGPFKLHCDDIGPANMLVNNVQELKIVEVVDVEWSYIAPVQLATVPWWILQERPDSWPFDITRRDMFPKYSDKFRRILEEEEALMPAVQGPRLSELVKRSEEDGSMWLHMLVVTTPDWVELAAEVRGRGEVQSLVARKLEENERYWSVVRETRKMVEEVKDGKRTHQDVIDHVEAAYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SQV9</accession>
    <name>A0AAN6SQV9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="4 14">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">C8A01DRAFT_47520</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="4 14"/>
    <dbReference type="EMBL" id="MU854415">
        <property type="protein sequence ID" value="KAK4038945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SQV9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23284">
        <property type="entry name" value="beta-trefoil_MIR_PMT2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000012">
        <property type="entry name" value="Protein O-mannosyl-transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="ArnT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="PMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050:SF46">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="212"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="266"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="586"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="628"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="654"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="685"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="320"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="386"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="450"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAK4038945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="727" mass="82309" checksum="A4243BD2386F40E5" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SR90</accession>
    <name>A0AAN6SR90_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_15963</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854384">
        <property type="protein sequence ID" value="KAK4040129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SR90"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4040129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="575" mass="65311" checksum="B7D9627DB8EC1EC5" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SRD7</accession>
    <name>A0AAN6SRD7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_47051</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854399">
        <property type="protein sequence ID" value="KAK4039485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SRD7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000196">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000012">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF153">
        <property type="entry name" value="AFLATOXIN EFFLUX PUMP, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="153"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="329"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="362"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="389"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="453"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="63"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="555"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="565"/>
            <end position="574"/>
        </location>
    </feature>
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        </source>
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        </source>
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        </source>
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            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="574" mass="60307" checksum="45EFFAE087E2E8D1" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SRT5</accession>
    <name>A0AAN6SRT5_9PEZI</name>
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        <recommendedName>
            <fullName evidence="10">GATA-type domain-containing protein</fullName>
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        <name evidence="11" type="ORF">C8A01DRAFT_45962</name>
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    <organism evidence="11 12">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
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                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="12">CBS 284.82</strain>
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        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2025-10-08" version="5" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
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                <person name="Brannstrom I.O."/>
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                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
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                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
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                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
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                <person name="Ament-Velasquez S.L."/>
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                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
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                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
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    </reference>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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            <begin position="1278"/>
            <end position="1293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1295"/>
            <end position="1307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1344"/>
            <end position="1356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1395"/>
            <end position="1404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1412"/>
            <end position="1433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1441"/>
            <end position="1450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1465"/>
            <end position="1499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1507"/>
            <end position="1517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1524"/>
            <end position="1534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1670"/>
            <end position="1686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1696"/>
            <end position="1712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1720"/>
            <end position="1789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1839"/>
            <end position="1859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1871"/>
            <end position="1885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1957"/>
            <end position="1995"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4040252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="2017" mass="221142" checksum="74CBACEC2B8A5A4B" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SSC1</accession>
    <name>A0AAN6SSC1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_35467</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854375">
        <property type="protein sequence ID" value="KAK4040520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SSC1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd24142">
        <property type="entry name" value="ACL4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="71"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="356"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="365"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4040520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="396" mass="43817" checksum="B3A083ECE16A2BC2" modified="2024-10-02" version="1">MAPTKPKKKSHKDKGRDRARAKGAAAQSPNVNPRELLAQATSFLEEGDPETAARIALAAYEHIGEGGRQAGAALSLLGQIHVELGEVDTARAFFAAAVKTDEDGSLPEDIGGGPEKFLWLAQLSDEGGQDSVSWFERGAAALRSQIQALTESLESRPLTRDTQEAVIAEKRKRLAETLCAVVEVYMTDLSWEEDAEQRCEALVTEATMLAPESAETWQTVANVRISQTRTEEAQEALKRSLGLWSDLAPEDPAVPPFPSRVSLVRLLIEVDMEKQAMDVTELLIAEDDRSVEALYLGGYAKYISGEKLKNQGQPSDAEAWKSFWRSSRKWLTQCLKVFKQEEYEDERLGEHAQDLLNSINSELGEAAEDGDDGDAWEDTDDEEWEGLDDDEDMEMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SSC3</accession>
    <name>A0AAN6SSC3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_34617</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854359">
        <property type="protein sequence ID" value="KAK4041314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SSC3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044281">
        <property type="term" value="P:small molecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000439">
        <property type="entry name" value="Non-ribosomal peptide synthetase OfaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF422">
        <property type="entry name" value="BCDNA.GH02901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="583"/>
            <end position="661"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4041314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="956" mass="105368" checksum="1374190871B61334" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6ST15</accession>
    <name>A0AAN6ST15_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Nucleoporin Nup120/160-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_33842</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854346">
        <property type="protein sequence ID" value="KAK4042079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6ST15"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059141">
        <property type="entry name" value="Beta-prop_Nup120_160"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056548">
        <property type="entry name" value="HEAT_Nup120"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021717">
        <property type="entry name" value="Nucleoporin_Nup160"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048884">
        <property type="entry name" value="Nup120_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21286">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21286:SF0">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11715">
        <property type="entry name" value="Beta-prop_Nup120_160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23300">
        <property type="entry name" value="HEAT_Nup120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21486">
        <property type="entry name" value="NUP120_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup120/160 beta-propeller" evidence="5">
        <location>
            <begin position="74"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin Nup120 helical" evidence="6">
        <location>
            <begin position="612"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin nup120-like HEAT repeat" evidence="7">
        <location>
            <begin position="837"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="768"/>
            <end position="787"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF11715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF21486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF23300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4042079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1244" mass="138671" checksum="5FE667E7A53B730D" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6ST18</accession>
    <name>A0AAN6ST18_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_45809</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854366">
        <property type="protein sequence ID" value="KAK4040988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6ST18"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4040988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="168" mass="18122" checksum="74D081A877DBA007" modified="2024-10-02" version="1">MANQTKQYFLAPSWDYPPNGPIALGNIIISPSRPSTAYTLGIWTKFVEFLGLSLGFETTHKAHDMFRFERVHTEEFFPDEAYLSAALRDQRVQRTLAAGRRAKMMGRAVGNKGVYVIVGVKTVSGAHVKSVDSRGYGALAGVAVDAALVGAPVPAAVGLVGGVKWEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6ST40</accession>
    <name>A0AAN6ST40_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">D-lactate dehydrogenase (cytochrome)</fullName>
            <ecNumber evidence="6">1.1.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">C8A01DRAFT_14700</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(R)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13521"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding oxidoreductase/transferase type 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.4" evidence="6"/>
    <dbReference type="EMBL" id="MU854355">
        <property type="protein sequence ID" value="KAK4041572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6ST40"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004458">
        <property type="term" value="F:D-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008720">
        <property type="term" value="F:D-lactate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903457">
        <property type="term" value="P:lactate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000014">
        <property type="entry name" value="D-lactate dehydrogenase (Cytochrome), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.45.10:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2740:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="entry name" value="Vanillyl-alcohol Oxidase, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-bd_oxidored_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748:SF116">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE (CYTOCHROME) (AFU_ORTHOLOGUE AFUA_7G02560)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="10">
        <location>
            <begin position="179"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00051436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK4041572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="611" mass="66932" checksum="BA0CFF67933B7392" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6ST95</accession>
    <name>A0AAN6ST95_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein PNG1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_14582</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transglutaminase-like superfamily. PNGase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854352">
        <property type="protein sequence ID" value="KAK4041737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6ST95"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000224">
        <property type="term" value="F:peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.620.30:FF:000004">
        <property type="entry name" value="Peptidase (PNG1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.620.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050883">
        <property type="entry name" value="PNGase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143">
        <property type="entry name" value="PEPTIDE N-GLYCANASE PNGASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143:SF19">
        <property type="entry name" value="PEPTIDE-N(4)-(N-ACETYL-BETA-GLUCOSAMINYL)ASPARAGINE AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Transglutaminase-like" evidence="5">
        <location>
            <begin position="690"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="216"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="852"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="229"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4041737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="941" mass="103940" checksum="8E4E31A72C325EBB" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6STF5</accession>
    <name>A0AAN6STF5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nucleolar protein 16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_45201</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the biogenesis of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the pre-66S ribosomal particle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NOP16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854353">
        <property type="protein sequence ID" value="KAK4041660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6STF5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019002">
        <property type="entry name" value="Ribosome_biogenesis_Nop16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13243">
        <property type="entry name" value="HSPC111 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13243:SF1">
        <property type="entry name" value="NUCLEOLAR PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09420">
        <property type="entry name" value="Nop16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="114"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="135"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4041660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="230" mass="25970" checksum="07E1BCE67C436732" modified="2024-10-02" version="1">MGRELQKRKRRSSRAKVTMPNRRKKALNPLGNDIIAKNWNKKETLSQNYTRFGLVAKLGKTTGGTAPSNKSNLNTATDPLAAQSANQGLLQVREVKVERDAAGRITRVLRDTNPLRDPLNALDSDSEGDDGSGEQLRREQAQQKRYEEWSGFQEDASRPEVLRALEREAGRPTEKTVRHASEREVEWLRRLVERYGEDVAAMARDGKLNPMQQTAADIRRRLKKAGLVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6STF8</accession>
    <name>A0AAN6STF8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_14426</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854349">
        <property type="protein sequence ID" value="KAK4041932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6STF8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4041932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="212" mass="23209" checksum="6750701FA87C238E" modified="2024-10-02" version="1">MVPKGVQLSQAITPISIKPDKIFIALDESGNMTITGDIRNTTAWHPHSPSFEWWNFTTTVTTSQGLSSLTVEVIDGGSSSTIYSNGGNGFPLETDIIPQAQLSCGIVFMGRGYVLSLTVRDDFRLQNLKLTVPIPVQQTGSIVPRFEPYLLNMEKTGALEDAGYSLYTASLDVRPGNMYTTIMSYGLSGRGGLRDVDMLFVLWKGLGRCPYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6STJ5</accession>
    <name>A0AAN6STJ5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Transmembrane amino acid transporter protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">C8A01DRAFT_45337</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854356">
        <property type="protein sequence ID" value="KAK4041483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6STJ5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061459">
        <property type="term" value="F:L-arginine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005313">
        <property type="term" value="F:L-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005290">
        <property type="term" value="F:L-histidine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015189">
        <property type="term" value="F:L-lysine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015194">
        <property type="term" value="F:L-serine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005302">
        <property type="term" value="F:L-tyrosine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF678">
        <property type="entry name" value="VACUOLAR AMINO ACID TRANSPORTER 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="106"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="159"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="258"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="296"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="390"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="414"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="533"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="11">
        <location>
            <begin position="35"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="342"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK4041483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="557" mass="59069" checksum="BFFD284AA02621D9" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SUQ7</accession>
    <name>A0AAN6SUQ7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Translation protein SH3-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_44267</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854336">
        <property type="protein sequence ID" value="KAK4042773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SUQ7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06089">
        <property type="entry name" value="KOW_RPL26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000009">
        <property type="entry name" value="60S ribosomal protein L26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005756">
        <property type="entry name" value="Ribosomal_uL24_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041988">
        <property type="entry name" value="Ribosomal_uL24_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01080">
        <property type="entry name" value="rplX_A_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11143">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L26 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16906">
        <property type="entry name" value="Ribosomal_L26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="KOW" evidence="5">
        <location>
            <begin position="52"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4042773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="138" mass="15521" checksum="8AF569E06AB46C72" modified="2024-10-02" version="1">MAKVSANVSSSRRKSRKAHFSAPSSIRRNIMSAPLSKELREKYNVRSMPIRKDDEVTIVRGLNKDKEGKVTSVYRLKYVIHIERVTRDKASGQSVPLGIHPSNVVITKLKIDKDREDILARIKAGREQVAKAKGKKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SUV6</accession>
    <name>A0AAN6SUV6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Exonuclease 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">C8A01DRAFT_13417</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854333">
        <property type="protein sequence ID" value="KAK4042966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035312">
        <property type="term" value="F:5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09908">
        <property type="entry name" value="H3TH_EXO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09857">
        <property type="entry name" value="PIN_EXO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000011">
        <property type="entry name" value="exonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000002">
        <property type="entry name" value="Exonuclease 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037315">
        <property type="entry name" value="EXO1_H3TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044752">
        <property type="entry name" value="PIN-like_EXO1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029190">
        <property type="entry name" value="Rrp14/SURF6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029188">
        <property type="entry name" value="Rrp14_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019974">
        <property type="entry name" value="XPG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF65">
        <property type="entry name" value="DNA DAMAGE-INDUCIBLE PROTEIN DIN7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RRP14"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00841">
        <property type="entry name" value="XPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="8" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="16">
        <location>
            <begin position="4"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="15">
        <location>
            <begin position="137"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="570"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="628"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="666"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="715"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="809"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1077"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1171"/>
            <end position="1319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="633"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="673"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="818"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="857"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
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            <end position="909"/>
        </location>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="910"/>
            <end position="920"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
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            <end position="964"/>
        </location>
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            <end position="1130"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
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        </location>
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    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="1241"/>
            <end position="1252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
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            <end position="1288"/>
        </location>
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    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="1289"/>
            <end position="1306"/>
        </location>
    </feature>
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        <location>
            <begin position="1309"/>
            <end position="1319"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010563"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK4042966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="19">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1319" mass="147039" checksum="56315D1129B490BB" modified="2024-10-02" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SV86</accession>
    <name>A0AAN6SV86_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_31952</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854323">
        <property type="protein sequence ID" value="KAK4043852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4043852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="235" mass="24983" checksum="84FBDE0E46D04B50" modified="2024-10-02" version="1">MPTQPHHPVKPSPMRNLSEYAVADTPGTAGPEFVGAGDYLQARFAPISPLAVAGGAHTDPHGTGHQTHQGGSAPDPKERGMPTALERGVRGGSGPVNDAERWGTRYVNPGEVPRGTKQNENVEAEAQMEMYPEGKVADAVERKRGMQTQTQTHRARRGSVNVSAAAVRGRSPPGGLHGRGRGEVTLEAGEADLERKKQQQAAARKQVMDARKRGEDVDGRGTTGPSGRQPRAEID</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SVG9</accession>
    <name>A0AAN6SVG9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATP synthase subunit 5, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">C8A01DRAFT_43514</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase delta chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854326">
        <property type="protein sequence ID" value="KAK4043568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SVG9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.30">
        <property type="entry name" value="MOB kinase activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.20">
        <property type="entry name" value="N-terminal domain of the delta subunit of the F1F0-ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01416">
        <property type="entry name" value="ATP_synth_delta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026015">
        <property type="entry name" value="ATP_synth_OSCP/delta_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020781">
        <property type="entry name" value="ATPase_OSCP/d_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000711">
        <property type="entry name" value="ATPase_OSCP/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005301">
        <property type="entry name" value="MOB_kinase_act_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036703">
        <property type="entry name" value="MOB_kinase_act_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01145">
        <property type="entry name" value="ATP_synt_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22599">
        <property type="entry name" value="MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03637">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00213">
        <property type="entry name" value="OSCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00125">
        <property type="entry name" value="ATPASEDELTA"/>
    </dbReference>
    <dbReference type="SMART" id="SM01388">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101152">
        <property type="entry name" value="Mob1/phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47928">
        <property type="entry name" value="N-terminal domain of the delta subunit of the F1F0-ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00389">
        <property type="entry name" value="ATPASE_DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR605301-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK4043568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="444" mass="48692" checksum="72AF7AF90389C264" modified="2024-10-02" version="1">MSSFLTTVNNRTKNQFRPRVPGKGGATSYQLRQYAEATLGGGSLRKVVKLPEGEDENEWLAVNMVDFYNQINLLYGAITEFCSPQSCPEMKATDEFEYLWQDSENYKRPTKMPAPAYIEQLMSWVQGNIDNEAVLPSRIGVPFPKSFPALVRQIFKRMYRVYAHIYCHHYPVIRELGLEPHLNTSFKQYVLFIDEHNLASGKDYWGPLGDLVDSMLRITMFPRQALLRSARAAAPQRAFLGQIRTFAAPASSEKVNPPVALFGLDGTYATALYTAAVKTSSLEPTAKGLAALGSLIQKDAKLVTILEAPTLSAADKSAIVAELQKNTGASGETVKNFLATLAENNRLGLLPGVCNKFSELMSAARGEVEMVVTSAQPLDNKTLTRLEAAVSKSSYVGAGKKLKVKNTVNPDIVGGLVVEVGDRTIDLSVSSKLAKMNKLLTDTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SVW4</accession>
    <name>A0AAN6SVW4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_31673</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854321">
        <property type="protein sequence ID" value="KAK4044076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SVW4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="299"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="378"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="406"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="464"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4044076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="579" mass="62144" checksum="54A7331126175FA6" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P408</accession>
    <name>A0AAN6P408_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_21437</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854878">
        <property type="protein sequence ID" value="KAK4031323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P408"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="27"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4031323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="303" mass="33614" checksum="BEE61325E2C5E9E5" modified="2024-10-02" version="1">MAWTEQGNSIFAFAVVLSVFSTAAVALRFVCRGRLLHVLGLSDWFLLFTLMFALANTCVIGIQAAVGLGLPLPEIPLGEKESFFKLVYAGTLVVHLSLILTKISVLLLFLDIFVIGWPRKTTYVVVVLVTLFGIWLVVSNILTCIPIDSFWKQDVSDLRCLGSQKWHADAAVNLVLDIAIFCLPLPAVWPVSLPRRQKLWLYIVFALGFFVCLASALRLAFLVSRPGPPSIGLVYWMALEVHLSIVIACIPTLHPLAVRLWPRHFGRSDDNKTDNGGELSRLSTRISFGMRPLRLPESPDDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P4H5</accession>
    <name>A0AAN6P4H5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">mitogen-activated protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_51364</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="1"/>
    <dbReference type="EMBL" id="MU854748">
        <property type="protein sequence ID" value="KAK4031609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P4H5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050538">
        <property type="entry name" value="MAP_kinase_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016">
        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016:SF56">
        <property type="entry name" value="MAPKK KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="178"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4031609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="399" mass="44495" checksum="95908092EB2FC47C" modified="2024-10-02" version="1">MEFISCFSLASHFHISHQPSFFAVDTSSNMRLTLTVLNIGHVRSRLGDSAALATLGRMGNIHVRGTEIAKVQCSFEIDRETNVVMFYDRSASQSSQVFDENAVPFEHGRLRRVVVEKGMNTIIGMDGVGRDLLAEREGSRLEENPHLARSVIGSDTVAPTGMETRIHALGPRQPRIRWKPRESLGVGRFGEVYDGLDLDHGTRMAVKVITQPINPGGPPPWALLKREVEILSSIKHKNIVDYIASQGWEEQKPEIFMSLKDGTLRSLVLGSGSIRAYDHAGRMCHDMLQALDYLAAQGIIHRDLKPEKILYKGQDRGYEFQLADFDLSSHQYQIAVAPNAGSPFYMAPESLFVTVVWMLDVGGLRRLEETSTNYEEIKDAVLSAANLPVCSRFRKMGTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P4I1</accession>
    <name>A0AAN6P4I1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_41944</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854748">
        <property type="protein sequence ID" value="KAK4031608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P4I1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4031608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="410" mass="45776" checksum="EAF724BBE9C91177" modified="2024-10-02" version="1">MPTDIQGEGLHIAHDALAALAENPELLDRARARFSETPRYYPSYRSLLGSPTQPPSPDRRSEAQKRRERKRIEIKFEQEASMVFRQFDDQTCEELERLYCQPGYQRPPGVEGFDGHAHLNVKTRWTEQGIWREGYDLQWPVQRLWKHEELPSGCEASEERERDAPRPYHQFVYHVSKERERIQDELNPKTQPPGHGNFGRFGPPPAADSAARAQEGPVAVPPDINTTAYERVKSLWIKRNIWNVKWGVLPGMAWKHERPFDEMLEEALAAETPTKAPTAPQAISTAEMLENAISPPNSAAGGVRSPGGFGEDAKKRLAELDKALFDTLRGVSNNGVGTLKMPDTLDTGSVALGPVHSSKVSKRGKVGRPAPQRRRAVALESGSLAGPPRRSKRLQALRDSKSAATARGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P509</accession>
    <name>A0AAN6P509_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">PHD/FYVE-zinc-finger like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_21046</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854701">
        <property type="protein sequence ID" value="KAK4031794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17919">
        <property type="entry name" value="DEXHc_Snf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056616">
        <property type="entry name" value="Chromo_MIT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041684">
        <property type="entry name" value="Znf-PHD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623:SF17">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23615">
        <property type="entry name" value="Chromo_MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15446">
        <property type="entry name" value="zf-PHD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="838"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="1143"/>
            <end position="1294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="116"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="207"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="506"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1393"/>
            <end position="1416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1428"/>
            <end position="1591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1635"/>
            <end position="1654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="124"/>
            <end position="134"/>
        </location>
    </feature>
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        <location>
            <begin position="219"/>
            <end position="232"/>
        </location>
    </feature>
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        <location>
            <begin position="259"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="305"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="511"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1393"/>
            <end position="1403"/>
        </location>
    </feature>
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        <location>
            <begin position="1459"/>
            <end position="1470"/>
        </location>
    </feature>
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        <location>
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            <end position="1580"/>
        </location>
    </feature>
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        <location>
            <begin position="1635"/>
            <end position="1648"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1725"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4031794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1725" mass="194027" checksum="A6F9313EF850EC85" modified="2024-10-02" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P5K6</accession>
    <name>A0AAN6P5K6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DnaJ homologue subfamily C member 28 conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_50978</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854639">
        <property type="protein sequence ID" value="KAK4032178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P5K6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018961">
        <property type="entry name" value="DnaJ_homolog_subfam-C_membr-28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39394:SF1">
        <property type="entry name" value="DNAJ HOMOLOGUE SUBFAMILY C MEMBER 28 CONSERVED DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF09350">
        <property type="entry name" value="DJC28_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="271"/>
            <end position="340"/>
        </location>
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        <location>
            <begin position="22"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="434"/>
        </location>
    </feature>
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        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4032178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="557" mass="60786" checksum="8221DE1A852817DC" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P678</accession>
    <name>A0AAN6P678_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Arylacetamide deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_20394</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
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            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854599">
        <property type="protein sequence ID" value="KAK4032524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P678"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="3">
        <location>
            <begin position="586"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="60"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="197"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="258"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="429"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="678"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="482"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="494"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4032524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="910" mass="100105" checksum="9961FB9DB888C880" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P6R0</accession>
    <name>A0AAN6P6R0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">rhamnogalacturonan endolyase</fullName>
            <ecNumber evidence="4">4.2.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">C8A01DRAFT_41721</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endotype eliminative cleavage of L-alpha-rhamnopyranosyl-(1-&gt;4)-alpha-D-galactopyranosyluronic acid bonds of rhamnogalacturonan I domains in ramified hairy regions of pectin leaving L-rhamnopyranose at the reducing end and 4-deoxy-4,5-unsaturated D-galactopyranosyluronic acid at the non-reducing end.</text>
            <dbReference type="EC" id="4.2.2.23"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the polysaccharide lyase 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.23" evidence="4"/>
    <dbReference type="EMBL" id="MU854693">
        <property type="protein sequence ID" value="KAK4031837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P6R0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102210">
        <property type="term" value="F:rhamnogalacturonan endolyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10316">
        <property type="entry name" value="RGL4_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10320">
        <property type="entry name" value="RGL4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1120">
        <property type="entry name" value="Carboxypeptidase-like, regulatory domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051850">
        <property type="entry name" value="Polysacch_Lyase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029413">
        <property type="entry name" value="RG-lyase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029411">
        <property type="entry name" value="RG-lyase_III"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32018:SF1">
        <property type="entry name" value="RHAMNOGALACTURONAN ENDOLYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32018">
        <property type="entry name" value="RHAMNOGALACTURONATE LYASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14683">
        <property type="entry name" value="CBM-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14686">
        <property type="entry name" value="fn3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="Starch-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042863099" description="rhamnogalacturonan endolyase" evidence="10">
        <location>
            <begin position="20"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonan lyase" evidence="12">
        <location>
            <begin position="340"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonan lyase" evidence="11">
        <location>
            <begin position="410"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK4031837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="576" mass="63593" checksum="76BD2971D9EFDB65" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P6R6</accession>
    <name>A0AAN6P6R6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Carbohydrate esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_20250</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854582">
        <property type="protein sequence ID" value="KAK4032709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P6R6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000675">
        <property type="entry name" value="Cutinase/axe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33630:SF13">
        <property type="entry name" value="ACETYLXYLAN ESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33630">
        <property type="entry name" value="CUTINASE RV1984C-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01083">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01110">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042860736" evidence="7">
        <location>
            <begin position="22"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="8">
        <location>
            <begin position="275"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="248"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="256"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4032709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="311" mass="31105" checksum="A819B94783EBB904" modified="2024-10-02" version="1">MWPTPKIAFLLLSAHSLLVSGSPVDAEAVDAAVLAKRQCPQIHVFGARETTVSPGYGTAGQVVNLILGAYSGATSEAIVYPACGGQASCGGVQYGDSARQGTNAVASAVNSFNQRCPNAQMVLVGYSQGGQIMDNAVCGGPDTGAGITSTASPISAAALGQIKAVIEMGSPRYVAGLSYNVGTCTAQGFAPRPPGYVCGSNSASKIQSYCDAADPYCCTGSDQATHQGYGTKYGQAALNFVKSKLNSSSGGGGGQVTTPSTPTPTGGNTGSGGGSCSSLWGQCGGQGWAGPTCCSQGTCKAANQWYSQCLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P6U3</accession>
    <name>A0AAN6P6U3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_50561</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854582">
        <property type="protein sequence ID" value="KAK4032710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P6U3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="23"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="2">
        <location>
            <begin position="220"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4032710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="312" mass="35816" checksum="470CC486B505F7A7" modified="2024-10-02" version="1">MRLLNAATHALEEFVDDDHVPPYTILSHTWGAEEVTFKDLSSALTSPPVDWRAYKNKQGWPEIVNSAQHARNCGWRYIWIDTCCIDKSDVTDLSEAINSMFRWYECAEVCYAYLANVPPDHPTLVHPWTWSFRSSRWFRRGWTLQELLAPSFLEFLDRDWNPIGSRTNGPMKLSWRRASSVATKLSWAANRETTLVGDRTYSLLGLLGVNMPLIYGEGERAFTRLQHELIRSSSDESIFAWGSPMSECSRNIAHGVDSPILAPSPRDYEHTRGIVTWMFDKRRKGFAMTNAGLSLNAELLRMDPRHADRHPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P7D8</accession>
    <name>A0AAN6P7D8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DUF202 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_50223</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854550">
        <property type="protein sequence ID" value="KAK4033123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P7D8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052053">
        <property type="entry name" value="IM_YidH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34187:SF2">
        <property type="entry name" value="DUF202 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34187">
        <property type="entry name" value="FGR18P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="DUF202" evidence="8">
        <location>
            <begin position="170"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="118"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4033123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="287" mass="31632" checksum="949B7E48841F1B9C" modified="2024-10-02" version="1">MSTKAGEPALSRSATLQLTRRQSSKDRIRDILEGARERAESLDPNSANVSPRLQPLLDRSRRASDPCGSAPPPELGGSSNGHGIVTAQPERQRGLNYHSTVETSPAARRRSALRRKSSGQQPGQPSPQTVRPGEEDGRRERPRQQEESGWKRTLQYFKSIELENKGSVARDHLALERTFLAWLRTSLAFASIGIAITQLFRLNTSLAEDTKQAETLRQLGKPLGTTFLAVSILILLLGYNRYLQGQYWVIKGKFPASRGTIMVVALIAFSVTLASLVVILAVQNNPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P7I4</accession>
    <name>A0AAN6P7I4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_21591</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU855084">
        <property type="protein sequence ID" value="KAK4031161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P7I4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4031161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="61" mass="6732" checksum="3856908F072C57EA" modified="2024-10-02" version="1" fragment="single">NRLRCSLSTSIVGLLYISQSSSIASAKRLSYETSTFLPLSKRPYSISLTKASSDILLNRVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P7I7</accession>
    <name>A0AAN6P7I7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein S8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_50177</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854546">
        <property type="protein sequence ID" value="KAK4033196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P7I7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.30:FF:000001">
        <property type="entry name" value="40S ribosomal protein S15a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S15a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000630">
        <property type="entry name" value="Ribosomal_uS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035987">
        <property type="entry name" value="Ribosomal_uS8_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003115">
        <property type="entry name" value="PRK04034.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11758">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S15A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00410">
        <property type="entry name" value="Ribosomal_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56047">
        <property type="entry name" value="Ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4033196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="130" mass="14819" checksum="23E1D68F3E2D4AEE" modified="2024-10-02" version="1">MVRTSVLHDALNSINNAEKAGKRQVMIRPSSKVIVKFLQVMQRHGYIGEFEEVDNHRSGKIVVQLNGRLNKCGVISPRYNVRLAELEKWVVKLLPARQFGFVMLTTSAGIMDHEEARRKHVAGKIIGFFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P7Y4</accession>
    <name>A0AAN6P7Y4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_50788</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854612">
        <property type="protein sequence ID" value="KAK4032420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P7Y4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF30">
        <property type="entry name" value="PHOSPHORYLASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="21"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4032420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="347" mass="39009" checksum="BAD09B5A1F6F62AB" modified="2024-10-02" version="1">MVSPRAAQPARLLRSCPSLFHQFLPLTNPPSQSRCFFCTPRQCQVPSTSMSSTAAPLSTTTSPQPLARGTQLTSPSGRCYTIDETIYQRSRGRLLCCLYRASHEKKQYLLKDMLPGDYEYILDLQRLVDGSAHVRTLVDTIPDCHMFVYPFLDTNLHQVQTTAIAPALKKIILRDALAGLADLHDKGIYHTDIKPANIMMDSFSKSDGAIGFTNVQITDLEDAVHTPADIFSFGITAIYVWMDRMVFFLDEANAAEDPSDMILKLHVSHFVNDLDDFGGFAEYHGGEQDPFVQRVIGLLGTLKKRAPFSRWHPVDPQFQDLVSKMTCLDPLRLITAREALQHPWFSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P824</accession>
    <name>A0AAN6P824_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_40108</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854530">
        <property type="protein sequence ID" value="KAK4033444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P824"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4033444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="250" mass="27888" checksum="6A67509FDAFB5268" modified="2024-10-02" version="1">MAAQGRGRGGGNWGNNQGNNQGNNQGNNQQGRYNNRHNNNNNNNNNNNNNNNNHNQNNQGGNQGQGKYNNRRNSNWGNNQGNNQGNDQGSNQRQGKYNNKRSGSWDNNQQPPWADYVLAVLREDTFDSRELRSVFSAASLMLGLIWDKRRKSGVSDQAIARELQIPLDDCLQLQELSRRLIDASLAPDADGDIAMSDAPPDDAPPPPYEKNDTNPGFPRHNQDAVAKDRREIVEEVLRVIALGCRDLKGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P876</accession>
    <name>A0AAN6P876_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_19530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854523">
        <property type="protein sequence ID" value="KAK4033558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P876"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4033558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="73" mass="8454" checksum="C7E6E5A318852EF0" modified="2024-10-02" version="1">MFTIISRSRPTCLHARRGKNYISTERLAKEKLGTVAKESIFMKTITNNFTPYYAPLIPLLNRLRKAVFPKDKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P8C1</accession>
    <name>A0AAN6P8C1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_49897</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854523">
        <property type="protein sequence ID" value="KAK4033550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P8C1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39608">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G08640)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39608:SF2">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4033550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="141" mass="15890" checksum="21500DFDFC13B4EA" modified="2024-10-02" version="1">MVHGDTRARTGLTTFLLASSALIWVSAVIVMGILAYLVSRSWGGDHIIFELVIAVLTTAFFPLAFFLVVSPGFILLFNLIFSYLWIVAVSFTASDWSRSQSNLLLTVEAFSFIAFFFLLFNVLYDWHYGFYRPGARTRAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P8D2</accession>
    <name>A0AAN6P8D2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_39881</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854517">
        <property type="protein sequence ID" value="KAK4033648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P8D2"/>
    <dbReference type="Proteomes" id="UP001303115">
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
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        <location>
            <begin position="18"/>
            <end position="401"/>
        </location>
    </feature>
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        <location>
            <begin position="167"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="369"/>
        </location>
    </feature>
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        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4033648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="401" mass="41913" checksum="EBFF687F85D0A756" modified="2024-10-02" version="1">MLALLAGANVLLSNAAAQSTCYDTWGREDTNQQPCSAPGTDASATTWCCNKGDSCLSNGLCLSPGSNNLMTQQGCTDKDWGGSCNKLCPASNDQKLTAIPLIPCPTSFDSATNAIKFCCGPDPSACCANTSAWITLPAGTIIPSQDTTTSSSSSTSESNTNSSSLKIGLGIGLGIGIPILLVLLAVAYLLAGQPLHSRHRRRQQQRGKRKQGGGGGGGTNTEKTSDTSHTYPPPRWFGQRRKSFGHVDTNTNVRPSTDDDDGGHGGGPRWPGVGEGAHAWPPRVVVAGHGGPGAASTNNVARAMAQWARSPFGFGGMEPPPPSPKEMDGSSSCGGRRGRVRRETPSRLGAAELPSPDMNSGEWEGRGRGWKAGRRVHVAAEEVELPTPDTPERDVERGLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P8D3</accession>
    <name>A0AAN6P8D3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">RNA-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">C8A01DRAFT_51342</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854740">
        <property type="protein sequence ID" value="KAK4031641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
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        <property type="entry name" value="RBD_domain_sf"/>
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        <property type="entry name" value="RRM_dom"/>
    </dbReference>
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        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13948:SF3">
        <property type="entry name" value="FI21118P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13948">
        <property type="entry name" value="RNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00641">
        <property type="entry name" value="Zn_ribbon_RanBP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="203"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="13">
        <location>
            <begin position="308"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="382"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="G-patch" evidence="12">
        <location>
            <begin position="854"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="391"/>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
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            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
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            <end position="625"/>
        </location>
    </feature>
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        <location>
            <begin position="808"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="14"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
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            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="103"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="396"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="812"/>
            <end position="830"/>
        </location>
    </feature>
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        <location>
            <begin position="831"/>
            <end position="853"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK4031641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="935" mass="103519" checksum="0ADBF0CCA6CD2B7C" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P8H1</accession>
    <name>A0AAN6P8H1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_39907</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854518">
        <property type="protein sequence ID" value="KAK4033640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P8H1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4033640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="68" mass="7201" checksum="BDD41B9E10E27556" modified="2024-10-02" version="1">MDTSTSTQTSIMSSTQQSPSSKIVPPAPAPVKAPSTDAFLKDFTLVAEAAKRAQMAVLMRDFESVGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P8P4</accession>
    <name>A0AAN6P8P4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_41738</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854696">
        <property type="protein sequence ID" value="KAK4031821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P8P4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4031821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="381" mass="41877" checksum="6FF2E5B2FCC70145" modified="2024-10-02" version="1" fragment="single">MSRARSHSKRRQDANHDHDTNSLPVTKRPRIHRAAKKDQGAPDTVQADPLPAIVVASQAAPELEPRSGAAHEKAVDSDGEYEPGDDDEESDDEAEQSPETRNKSVLNGKVALDNRVSDEAEVKDEEASRAGPEKADAAKTAKSFASNIERFNYLFSQVVKSLVEWCQAQPVEEFLEGSSDGHALCRSAFIVLLKSNPTILSETLRSSIPTPVKEVLGRGDFSIGDLQTLPEVPARYKEVGCYLAVSAKDLAGGKVQDSARFVDLVRGVLSEVGAYLGSTARKRGMRERIREHRREIKRALQGRSKKPKGSFYHFAGRPGVETTFFLLARMDPAEESSKVKSLLLEGILQAYLGLVQEATYDAWWHNSLVVPFIDSIRASAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P8T1</accession>
    <name>A0AAN6P8T1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">50S ribosomal protein L30e-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_39679</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854506">
        <property type="protein sequence ID" value="KAK4033871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P8T1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004037">
        <property type="entry name" value="Ribosomal_eL8-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01082">
        <property type="entry name" value="RIBOSOMAL_L7AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="3">
        <location>
            <begin position="106"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="202"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4033871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="283" mass="31260" checksum="8A35B035CF7D3AE1" modified="2024-10-02" version="1">MASEDRVDVVDDKKLKKEKKSKDKAEKKDKKRSDSDGVRKEKKDKKKDKKTQDKLARALDAHLQADAAASFEDDENKADVDPEDLIKPAEELVPFALPLADDKTHKKIYKLIKKGAKLKSIHRGVKECEKAIKKCPPKTAASGEVPAPGLVIIAGDISPMDVIMHFPVLCEEHGVPYLYVRSRADLGVAACTKRATSVVMLKPEGKKNTGGAGGDKGKKKDADAEMEDADDDKKVSAEEYLEAWKDLIKTADKQWKIQVQPWVKGTHPLQIADREKARLAASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P8Z1</accession>
    <name>A0AAN6P8Z1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Minichromosome loss protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_39649</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854505">
        <property type="protein sequence ID" value="KAK4033880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P8Z1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057646">
        <property type="entry name" value="WD40_WDHD1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022100">
        <property type="entry name" value="WDHD1/CFT4_beta-prop_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048591">
        <property type="entry name" value="WDHD1/CFT4_hel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19932">
        <property type="entry name" value="WD REPEAT AND HMG-BOX DNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19932:SF10">
        <property type="entry name" value="WD REPEAT AND HMG-BOX DNA-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20946">
        <property type="entry name" value="Ctf4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12341">
        <property type="entry name" value="Mcl1_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24817">
        <property type="entry name" value="WD40_WDHD1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="WDHD1 first WD40" evidence="9">
        <location>
            <begin position="12"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="230"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="WDHD1/CFT4 second beta-propeller" evidence="7">
        <location>
            <begin position="415"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="domain" description="WDHD1/CFT4 helical bundle" evidence="8">
        <location>
            <begin position="762"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="331"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="702"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="712"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="739"/>
            <end position="753"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4033880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="871" mass="96930" checksum="D045CFC9A263E9A8" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P973</accession>
    <name>A0AAN6P973_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">C8A01DRAFT_49472</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854497">
        <property type="protein sequence ID" value="KAK4034053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P973"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000008">
        <property type="entry name" value="26S protease regulatory subunit 10B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000027">
        <property type="entry name" value="26S protease regulatory subunit 10B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000034">
        <property type="entry name" value="26S protease regulatory subunit 10B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="10">
        <location>
            <begin position="579"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="432"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK4034053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="802" mass="88932" checksum="8AE1EC6CFDF0C089" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P9C9</accession>
    <name>A0AAN6P9C9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7492 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_41700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854688">
        <property type="protein sequence ID" value="KAK4031862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P9C9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055915">
        <property type="entry name" value="DUF7492"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24320">
        <property type="entry name" value="DUF7492"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7492" evidence="1">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4031862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="174" mass="18812" checksum="9FB57EC9E31B7F68" modified="2024-10-02" version="1">MRNYNDGQCYESIPNTGDIEGIVGFRKQFTKTETVLCQADLQIPNDAPVGKTLTIIWVWDWPTMNVQGVAVPPASYNTTSGESFVTTPELYTGVLDFKIVEPCDASLGDVKGPTCESQKSKANAQFDANQAPTARGIATQMAEPFLVQVTQAGFNVPSATADNAHQDPHCQPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P9E2</accession>
    <name>A0AAN6P9E2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">T-complex protein 11-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_19025</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TCP11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854494">
        <property type="protein sequence ID" value="KAK4034120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P9E2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010737">
        <property type="term" value="P:protein kinase A signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008862">
        <property type="entry name" value="Tcp11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12832:SF11">
        <property type="entry name" value="LD23868P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12832">
        <property type="entry name" value="TESTIS-SPECIFIC PROTEIN PBS13 T-COMPLEX 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05794">
        <property type="entry name" value="Tcp11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="610"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="77"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4034120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="686" mass="76857" checksum="041CC89F306BE6BE" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P9M3</accession>
    <name>A0AAN6P9M3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2,6-dihydroxypyridine 3-monooxygenase substrate binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_39225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854485">
        <property type="protein sequence ID" value="KAK4034299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P9M3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053212">
        <property type="entry name" value="DHP_3-monooxygenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054707">
        <property type="entry name" value="DhpH_subs-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47469">
        <property type="entry name" value="MONOOXYGENASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47469:SF2">
        <property type="entry name" value="OS06G0597600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22607">
        <property type="entry name" value="FAD_binding-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2,6-dihydroxypyridine 3-monooxygenase substrate binding" evidence="1">
        <location>
            <begin position="187"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4034299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="425" mass="46886" checksum="C046B6128C68181B" modified="2024-10-02" version="1">MHFVIVGGSLGGLATGIALKALGHDTTILERNTAPLLHDQGAGIIAGSHALDFLERYNRSRRQEVAVRSDRRQYLNREGNVVHEGGSEQYMSSWDLTYHLMRANYDGVANPYCDVPPPDRSHGKAVYLHDHTVTAVVDAGDNSIRVSWQSTSDPSRTGILDADRAVGADGPSSFVRSLFTPGLERKYAGYCALRGTVVEHEASSEARATLANRFTFYHGPGVQILAYLIPGVHGTVEPGQRLINFVYYANFPEGSPELDGILTDRHGRRRRITVPPGLTDPKAWEHQQAIARERLPPQFAELVCKAQRPFVQAVTDVLSPANEFLGGKVVLVGDALASFRPHTVASTSQAAFDAMLYADYVAGRVGRDEWKRLTMGYARFVYKRGVDMGERSQHQLLPLEEYVRDRDEASVPIRGEMFPESATAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PA56</accession>
    <name>A0AAN6PA56_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter F family member 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_38955</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854474">
        <property type="protein sequence ID" value="KAK4034563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PA56"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000011">
        <property type="entry name" value="Putative ABC transporter ATP-binding component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF135">
        <property type="entry name" value="ATPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G16440)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="33"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="490"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="116"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="410"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4034563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="706" mass="76832" checksum="DEA5297F46D4E704" modified="2024-10-02" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PAG5</accession>
    <name>A0AAN6PAG5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">diphosphoinositol-polyphosphate diphosphatase</fullName>
            <ecNumber evidence="2">3.6.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">C8A01DRAFT_38808</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + H2O = 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:79699"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:74946"/>
            <dbReference type="ChEBI" id="CHEBI:77983"/>
            <dbReference type="EC" id="3.6.1.52"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:79700"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + H2O = 1D-myo-inositol hexakisphosphate + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22384"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="ChEBI" id="CHEBI:58628"/>
            <dbReference type="EC" id="3.6.1.52"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:22385"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein-tyrosine phosphatase family. Atypical dual-specificity phosphatase Siw14-like subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.52" evidence="2"/>
    <dbReference type="EMBL" id="MU854468">
        <property type="protein sequence ID" value="KAK4034705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PAG5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052840">
        <property type="term" value="F:inositol diphosphate tetrakisphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000035">
        <property type="entry name" value="Tyrosine phosphatase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004861">
        <property type="entry name" value="Siw14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126:SF48">
        <property type="entry name" value="INOSITOL PHOSPHATASE SIW14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03162">
        <property type="entry name" value="Y_phosphatase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="278"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="10">
        <location>
            <begin position="120"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="47"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK4034705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="317" mass="35741" checksum="B92BAC51E86412F5" modified="2024-10-02" version="1">MANKVMSKRSGRPYGEDDTEKQAEDHQEKRMGRHEDARSEGRDRQKSTSTATTHSSQSSLEPSPVIRPADGQPEIDTLELGPPARSDSELRDAFHPTQQQVAYSIHELEKSLPTESRPANFGVVVPGVYRSSFPQSEDYGFIEGLKLKTIVTLVQKEFPQGYDAFLHRNDIKHAIFDMKGTKKEDIPTATMKSILRVVLDRRNHPLLIHCNHGKHRTGCVIGIIRKLSGWNLSNIITEYKAYAEPKTRECDISYITGFELANISNLFREASPPFRTTGFLRAVFFALVMLVVWLVSGPEMARDRIAGGSKREMLTED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PB30</accession>
    <name>A0AAN6PB30_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_19065</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854496">
        <property type="protein sequence ID" value="KAK4034072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PB30"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4034072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="66" mass="7766" checksum="48EE4B9414D535E6" modified="2024-10-02" version="1" fragment="single">IVEPERKQARGRIWISGQRFTCHWTELWAGDSDAEVLINDRHERRMEAFNRVLSRHSGDGKSGMRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PB61</accession>
    <name>A0AAN6PB61_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Puromycin N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_48571</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854452">
        <property type="protein sequence ID" value="KAK4035184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PB61"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF2">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="91"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4035184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="224" mass="24692" checksum="2CDD049F5C4811CF" modified="2024-10-02" version="1">MPLLLRPAKEDDSTKIGAIGRDAFSGTLSRSIFPPHLHSKSETGDPGLDEAQWRAARNLRRMREGKPTYVVVDVPEDGSGDERVVGFAQWELPSQETPSTAGAAVEIEPDPLPASLDQEKLLEMYRLIEDETKKALGPEGYSNMWYLMSVAIDPTQQRRGIGRMLVQHGLDQAAKAGKDAFLISTPEGRGLYYALGFRDVTEPITLGPTPHSLMIWKNPETGVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PBT1</accession>
    <name>A0AAN6PBT1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ferri-bacillibactin esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_18113</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the esterase D family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854452">
        <property type="protein sequence ID" value="KAK4035179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PBT1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052558">
        <property type="entry name" value="Siderophore_Hydrolase_D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40841">
        <property type="entry name" value="SIDEROPHORE TRIACETYLFUSARININE C ESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40841:SF2">
        <property type="entry name" value="SIDEROPHORE-DEGRADING ESTERASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4035179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="310" mass="34515" checksum="C8FA144238C82184" modified="2024-10-02" version="1">MATTLVSNWAFTPFPPFPPTLFPNLAVWNATSTLSNMTYQIQISWPFEWETREVLGRSALTMYVLDGNAMGMTAAEGFKRRKPVSFGQPDSIVVSIGYPLTNSVYDMVNRFIDYKPPPGNQDSPSGADPFLDFIDDALRPWVHNTVFPHVDFTRDALFGHSFGGLLVTYALISRPDMFDTYLAASPALEVQHSSVLEDVIARFGTGDPASSAYYTSTGCNATPTLPALMITYGSVEEFPARRRTENETAFQERKNYFRPLGMTEHCHDLFDRVKASGKVRDVVLKEYVGQDHAGVAASAITDGIDYFVDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PCB4</accession>
    <name>A0AAN6PCB4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6604 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_48910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854466">
        <property type="protein sequence ID" value="KAK4034762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PCB4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046539">
        <property type="entry name" value="DUF6604"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016864">
        <property type="entry name" value="UCP028035"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38795">
        <property type="entry name" value="DUF6604 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38795:SF1">
        <property type="entry name" value="DUF6604 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20253">
        <property type="entry name" value="DUF6604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028035">
        <property type="entry name" value="UCP028035"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6604" evidence="2">
        <location>
            <begin position="9"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="739"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="750"/>
            <end position="759"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4034762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="968" mass="108325" checksum="63FBD1D0BAFBEE4D" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PDP9</accession>
    <name>A0AAN6PDP9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Bacteriocin-protection protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_49158</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854479">
        <property type="protein sequence ID" value="KAK4034446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PDP9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13376">
        <property type="entry name" value="OmdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4034446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="211" mass="23465" checksum="9A92779957E735DC" modified="2024-10-02" version="1">MTARTRLAAKALQAATPTPVPAAAATQPIRLFADVAAWETWLESNHADPTGLWLKISKKGSSVASVTYEEALDTALCFGWIDGQKKGHDADHFIQRFTPRRKRSMWSKRNVAKVAVLIEAGRMRQAGQAEIDAAKADGRWEKAYSSPSVMEVPDDFQAALDRNKKAKTFFEGLGKTKRYAFLWRIATTKREETRQKKIGQFVGLLAEGKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PE08</accession>
    <name>A0AAN6PE08_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_16746</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854406">
        <property type="protein sequence ID" value="KAK4039227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PE08"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12339">
        <property type="entry name" value="RRM2_SRSF1_4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003:SF51">
        <property type="entry name" value="SERINE-ARGININE PROTEIN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="7"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="110"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="75"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="181"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="84"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="220"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="254"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="267"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4039227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="325" mass="37020" checksum="8223D715A19D17C0" modified="2024-10-02" version="1">MTEVSSTRLYLGNLPRNATKADVEAHFATHGTGEITEIKLMNGFGFIEYKDAMDARDVVPDGSDFMGERLTVQFARGSRHREQGPGGGGGGGGGYNHDRNSAPRPRRTPHRMQITGLPNDTSWQDLKDFARQSGLDVVYSETNRNGSNEGFVEFETAADLRTAVEKLDGREFKNARVTCVANTQPDIPRGDRARSRSPRRPYPPPMDDYDRRGPPRGYSPRRDGYREGAYRERTPPPHRDYYDDRRGGYRSPPRRGPPMDDYPPPRGRYDDPYRGAPRDYPPADPYMNGRAAYHDRRGPPPPDFPPRDPYAREPYPPPRDYERRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PE77</accession>
    <name>A0AAN6PE77_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Polyketide synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_48664</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854455">
        <property type="protein sequence ID" value="KAK4035108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000019">
        <property type="entry name" value="Polyketide synthase type I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF20">
        <property type="entry name" value="HYBRID PKS-NRPS SYNTHETASE APDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22621">
        <property type="entry name" value="CurL-like_PKS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="8">
        <location>
            <begin position="8"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="9">
        <location>
            <begin position="961"/>
            <end position="1266"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="2177"/>
            <end position="2252"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="6">
        <location>
            <begin position="961"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="6">
        <location>
            <begin position="1109"/>
            <end position="1266"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="6">
        <location>
            <position position="993"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="6">
        <location>
            <position position="1168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4035108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2285" mass="249449" checksum="9026476CB50ED077" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PEB6</accession>
    <name>A0AAN6PEB6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosome biogenesis regulatory protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_38736</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in ribosomal large subunit assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the RRS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854465">
        <property type="protein sequence ID" value="KAK4034806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PEB6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007023">
        <property type="entry name" value="Ribosom_reg"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04939">
        <property type="entry name" value="RRS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="156"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="179"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4034806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="198" mass="22145" checksum="A06B8AF3EBEC79A9" modified="2024-10-02" version="1">MSTAAQKPPKLPVTVDKPTPYTFDLGLLLANDPNPVSLPTDPSTTLESHLTAVARDGTQVLINQLLTTCAITSTPAGVLLSLPAPQTPLPREKPIPTPRPETKWSAFAKRRGIKPKTREQRRNLQYNDGTGEFERKWGYKGANKAGQDDAIIEVSAKKEAERKEGTSVRGDKRREIREKVKRNERRMRKNQRNAEGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PET9</accession>
    <name>A0AAN6PET9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_18554</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854469">
        <property type="protein sequence ID" value="KAK4034682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PET9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043030992" evidence="1">
        <location>
            <begin position="20"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4034682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="148" mass="15634" checksum="728EAC8E252787B0" modified="2024-10-02" version="1">MKYFTILAPALGLLASASAIPLEERDDVQTVHLTFHGGPAEYSMAIPADGTVHPTNNGIAVNIIDAPDYNAFYQCQFHTQGDATLASSISPTGVNQIMVGPPAPITGVSCQGMCVPTYGDCYRNGQYVGPCCAGYCAANKCRPWVSPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PF42</accession>
    <name>A0AAN6PF42_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TLC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_36234</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854392">
        <property type="protein sequence ID" value="KAK4039783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PF42"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050846">
        <property type="entry name" value="TLCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13439">
        <property type="entry name" value="CT120 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13439:SF0">
        <property type="entry name" value="TOPOISOMERASE I DAMAGE AFFECTED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="7">
        <location>
            <begin position="69"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4039783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="367" mass="40674" checksum="4701CDCF3EC6BD5A" modified="2024-10-02" version="1">MRDPFPIPPIPALSRAVEPLAARLGMPTLPLHIHEVVGAALLYTFIQVVVSPVLSARFFPQHYPRHNRSKKANWDTHVVSLAQSLLINALALWVMYADDERSAMDQEQRVWGYTGGCGLIQALAAGYFVWDLGITLLNLDIFGLGLLAHAVSALAVYTFGFRPYLNYYSPTFILYELSTPFLNIHWFFDKLNMTGSKPQLYNGIALLATFFLCRLVWGTWQSAVVYADMWRGVSRPPSPEYLAAKAFADPLTAADPDANVMFFVAPDAAAAVPLWLTGVYLASNVVLNALNWYWFVKMVGAVRKRFVPPKPGAKERVAAVAAGVVPKAEKVTAVEDKEGVAVRQRRAHSIVEDVVPDSEELREGTIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PF66</accession>
    <name>A0AAN6PF66_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_36242</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854392">
        <property type="protein sequence ID" value="KAK4039791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PF66"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="249"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="508"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="171"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="525"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4039791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="548" mass="65487" checksum="0FFBA78ABA532C0D" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PFM9</accession>
    <name>A0AAN6PFM9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Large ribosomal subunit protein bL21m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_48584</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854453">
        <property type="protein sequence ID" value="KAK4035147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PFM9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028909">
        <property type="entry name" value="bL21-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036164">
        <property type="entry name" value="bL21-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21349">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21349:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL21M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00829">
        <property type="entry name" value="Ribosomal_L21p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141091">
        <property type="entry name" value="L21p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="51"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00044129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4035147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="225" mass="24673" checksum="869CF41470C50406" modified="2024-10-02" version="1">MSRALLRSVLELRAPVTRLAPSVRPATTATTAPTETATVRFFNQTAQHIEPAQPDPSIVPNAAQQAPSPLSPQQQYPSQRTPPTQPPPAPTGPLSASVRTLLPALAAQPGHYITIHIHGRGYLVTAGDSIRLPFKMPGVVPGNVLRLNRASVLGSRDFTLRGAPFVDERLFECRAVVTGAEAEPMRTMVKKKRRTRRSQRVNSKHKYTMLRISELRVKPEAVEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PFQ1</accession>
    <name>A0AAN6PFQ1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_16710</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854405">
        <property type="protein sequence ID" value="KAK4039268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PFQ1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF121">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4039268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="315" mass="33666" checksum="FEB266D2DA7B58F4" modified="2024-10-02" version="1">MSTMRKLPALRFLPLSLPGTRILSRPASSPLRTITTTPAPPRRENRERVAIVTGAARGIGRSIALRLAQDGYHITASDLPALQPQLDSLVSEITSSGTTKAHAHPADVTSPADIASLIHSSAATLGPLDTMVANAGIAQVKPLLDLTPEDFRRVFDVNVAGVHHCFQAAAKQMIAQDLSHQTPGEEIRGRLIAAASIVAFKPFALLGHYSASKWAVRGLSQVYAMELARHKITANAYAPGIVDTKMWELIDEGLGEKAGGRGKGEMMRQYSEELIALGRTSVPRDVAGLVSFLGSRDADYVTGQTFIVDGGIIFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PFV0</accession>
    <name>A0AAN6PFV0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cuticle-degrading protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">C8A01DRAFT_35861</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854383">
        <property type="protein sequence ID" value="KAK4040173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PFV0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04077">
        <property type="entry name" value="Peptidases_S8_PCSK9_ProteinaseK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000014">
        <property type="entry name" value="Proteinase K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="entry name" value="Peptidase S8 propeptide/proteinase inhibitor I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034193">
        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010259">
        <property type="entry name" value="S8pro/Inhibitor_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF58">
        <property type="entry name" value="ALKALINE PROTEASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05922">
        <property type="entry name" value="Inhibitor_I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6 7" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042974015" evidence="8">
        <location>
            <begin position="16"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="Inhibitor I9" evidence="10">
        <location>
            <begin position="31"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="9">
        <location>
            <begin position="138"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK4040173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="389" mass="39868" checksum="3654E5ADBC1B8613" modified="2024-10-02" version="1">MQLLTWATLLPLALAAPVIQPRGVQLIPGDYIVKLKDGASESTLQDAIRHVKTGGAKHVYRAGRFKGFAAKLSPQVLDAVSKLSEVEYIEQDAVITTQESITQTDNVPWGLARISHRAAGATSYVYDESAGEGTCSYIIDTGIYVAHSQFQGRATWLANFIDSSNTDGAGHGTHVAGTVGGVTYGVAKKTQLFAVKVLDANGSGTVSSVLAGIDFVASDAKNRTAAGGCPKGSVANMSLGGGKSESINSAAAAAVRAGVFFAVAAGNSDDDAKYYSPASEPTVCTVGATDVADVRAYFSNYGTGVDVFAPGVDVLSSWIGGVDKTNTISGTSMASPHVAGLGAYLLGLLGPKTPAELCQHLKDTATLGTITDLPSGTINALAFNGNADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PFX7</accession>
    <name>A0AAN6PFX7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerases I, II, and III subunit RPABC1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_48115</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854435">
        <property type="protein sequence ID" value="KAK4038234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PFX7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1340.10:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit RPABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.940.20:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit RPABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1340.10">
        <property type="entry name" value="RNA polymerase, Rpb5, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.940.20">
        <property type="entry name" value="RPB5-like RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00025">
        <property type="entry name" value="RNApol_Rpo5_RPB5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014381">
        <property type="entry name" value="Arch_Rpo5/euc_Rpb5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005571">
        <property type="entry name" value="RNA_pol_Rpb5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036710">
        <property type="entry name" value="RNA_pol_Rpb5_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000783">
        <property type="entry name" value="RNA_pol_subH/Rpb5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020608">
        <property type="entry name" value="RNA_pol_subH/Rpb5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035913">
        <property type="entry name" value="RPB5-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007129">
        <property type="entry name" value="PRK09570.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10535">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10535:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01191">
        <property type="entry name" value="RNA_pol_Rpb5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03871">
        <property type="entry name" value="RNA_pol_Rpb5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000747">
        <property type="entry name" value="RPB5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53036">
        <property type="entry name" value="Eukaryotic RPB5 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55287">
        <property type="entry name" value="RPB5-like RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01110">
        <property type="entry name" value="RNA_POL_H_23KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase Rpb5 N-terminal" evidence="8">
        <location>
            <begin position="12"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase subunit H/Rpb5 C-terminal" evidence="7">
        <location>
            <begin position="161"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4038234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="234" mass="26803" checksum="60DDB1D6BBA5D435" modified="2024-10-02" version="1">MEEESNASMHTKEVTRLWRSWRTIHEMVQDRGYELAEDEVKISLDRFRSEYTNDDGSPNRAKMQFSARPSESMIKKFTPPPTPSNPDPAPECGTIWIEFCPEKSSIGISVMKKFVEHCSNNNFKAGILVTAVALSAQARKVMTVTSQFTLIECFLEEDLLVNITHHELVPKHVLLSREEKTALLKRYRLKETQLPRILSKDPIARYLGLKKGQVVKIIRTSETAGRYASYRLCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PGL7</accession>
    <name>A0AAN6PGL7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_36268</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854393">
        <property type="protein sequence ID" value="KAK4039733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PGL7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="188"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="217"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4039733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="331" mass="34807" checksum="0BF1EA355DF40C1A" modified="2024-10-02" version="1">MDPSAHGGSPSHPLPSSHDSNNNNDHSQLRVRFAEGEPQASYKIYQPTPRRERPPPAASSAAQPAVYWDNKGGNDREIHRESDANLAGYTFYREGTPTPPDHEAPEKRLGHGKGLAAPVTDTSTAGGGTIRSDGDWSLADSNDVSPARKKRVLWAIIAAVVLIVVALGVGLGVGLSQGKAAAADPVQAPSSSLPASALNLSPAPTDPPTTTPGGTGAYADTTTGSAAAPRPTYNSDCPALNNTIYHVPGSTRSFKRLCGVDYSGSGATDLAHAYTESMADCMNSCALFDQCTACSWGYLQGDEGEKHRCYMKKDLKQAHTAASDWCFAILQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PGP8</accession>
    <name>A0AAN6PGP8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_15487</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854372">
        <property type="protein sequence ID" value="KAK4040674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PGP8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4040674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="295" mass="33347" checksum="258EA9373120A9EA" modified="2024-10-02" version="1">MGAPKQDNPPLLPPAHPPATTTTNATTPADAPPPYEPPAYELRPETAAPDPDELLDPSVLVIHGRFIYPVNPSGEADSEPAYQLSRAIHMQGTATEKMAFQRLDLRVRTIAAADGDVPSVSRRAKDVYELEHRKARPHLGFPFEAWLEPQTRKALGKVKIEKSPAFRSGFRAVKVVSEAEERYWERQGKKAKKGEYYFVVKEGSERDWEWSDVGGRVVASQVRERVAVEGGAEEVFKLKVLVPLSRRERDTLVALWCLWMWHIHVEEGIPKRTWGDRKRIMQMPRLYPGLEPGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PGX1</accession>
    <name>A0AAN6PGX1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_37707</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854432">
        <property type="protein sequence ID" value="KAK4038320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PGX1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4038320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="282" mass="31237" checksum="8FB1814EF0235E63" modified="2024-10-02" version="1">MADGSSTAREFCGGDDAEDLLDSLARALNAAGIPCVLWGKFLWQTHGVPTLWNALDLVVPDAKLAAASEVISKSKDLGFTLLACPDTTTCFHSEPNQTWEIPSFHLHIEGTEGRKDLEPRHRIPAAVTLFPQSETLWFLPQLDASLANPRANPLPRYLALASDTTALPTFVLDEIDMGRGVFKSDKTAVLVPRAHILTEALMRIMARDHGKDVGLFAGSAVGYMSFYVEKRGKLNIDLLPEPFGKLFRAYTSNDEKERMHMKEVLFRLMRAVGVPVEPEEYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PH68</accession>
    <name>A0AAN6PH68_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial carrier domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">C8A01DRAFT_47341</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854409">
        <property type="protein sequence ID" value="KAK4039136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PH68"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000107">
        <property type="entry name" value="Mitochondrial dicarboxylate carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050391">
        <property type="entry name" value="Mito_Metabolite_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45618">
        <property type="entry name" value="MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="39"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="127"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="227"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK4039136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="322" mass="34794" checksum="E9CFD9E693CD6941" modified="2024-10-02" version="1">MQAAKSEGRPAAAPSAAMAKGDNDKAVASSLARPRPVHYPFWFGGSASSMAACVRLQTRTGDMPKSMSGTFVHILKHNGPRGLYNGLSASLLRQITYSTTRFGIYEELKSRFTSSKTDPDTGKPKPPSLPLLIAMASTSGFIGGIAGNAADVLNVRMQHDAALPPSQRRNYAHAVDGLARMVREEGFASLFRGVWPNSARAAAMTASQLASYDVFKRTLLRATPMQDNLATHFSASFLAGVVAATVTSPIDVIKTRVMSATGGDHGVVALLREVYAKEGMRWMFKGWVPSFLRLGPQTICTFLFLESHRNVYRKINGIEEPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PHJ9</accession>
    <name>A0AAN6PHJ9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_46451</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854382">
        <property type="protein sequence ID" value="KAK4040213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PHJ9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF50">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="3">
        <location>
            <begin position="324"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="19"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="217"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="446"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="77"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="103"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="237"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="449"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="466"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="482"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4040213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="700" mass="74196" checksum="91B692C9324C84A9" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PI71</accession>
    <name>A0AAN6PI71_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_36414</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854396">
        <property type="protein sequence ID" value="KAK4039631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PI71"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4039631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="170" mass="18458" checksum="6B6381BC242EF4F9" modified="2024-10-02" version="1">MPSNNDSTASSSSSPPPYKAPTANADGHIAIEMDAPGGVRPNTAYRALPPNRYEPTTGMRDGHCCQCYFQLSPGTVTLGLVIFFVWFIFWIMDATGKAQVWDNIRAFRGGVWAQASGSIGASGVGFLFETRRLPDASQVSVEGHGISGLQHCLAWMVTSRLTRFTMQILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PIA8</accession>
    <name>A0AAN6PIA8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_15529</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854373">
        <property type="protein sequence ID" value="KAK4040618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PIA8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="198"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4040618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="264" mass="27088" checksum="EF7C36CAD0212AF4" modified="2024-10-02" version="1">MKPLYLLGTLAYGLRVEARRAPAAGVAARQWGEGGGGFGGWPGRGGGGSGVGGAVCEWTDHCLGDSCETENDCDGDLICRAGSCANAGAAQPTLTVGAPTPILRTTTITVTATPTTPSNPTCEWTGHCAGDPCQTENDCDGEMTCRAGKCGDASAPVATSTRRIRTSTRRVVTSTRRVVTSTRRVVTSTRPVVTSIRRTTTSTRRATIPPVPTRSTVQPQPTTTQNPPTPGCSDSPLACIGVSCQTDADCGGSLIICNDGVCGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PIB9</accession>
    <name>A0AAN6PIB9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Peptide hydrolase</fullName>
            <ecNumber evidence="14">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">C8A01DRAFT_36476</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Extracellular aminopeptidase that allows assimilation of proteinaceous substrates.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the peptidase M28 family. M28E subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="14"/>
    <dbReference type="EMBL" id="MU854398">
        <property type="protein sequence ID" value="KAK4039524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PIB9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF56">
        <property type="entry name" value="AMINOPEPTIDASE YDR415C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="METALLOPEPTIDASE M28 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 14" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0732">Signal</keyword>
    <keyword evidence="8 14" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042665214" description="Peptide hydrolase" evidence="14">
        <location>
            <begin position="20"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="15">
        <location>
            <begin position="171"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00043843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00043962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK4039524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="372" mass="39514" checksum="38070DEE55AC8B7C" modified="2024-10-02" version="1">MRVPAVLALLATGAWPVAAAPAIESLGTDAGLRLIKTSPADPGRWVTEEQKIRDYKSKGIGFVDVTDITDAQVLAALSAPDTQEKPFSAQAVSYPSNVGHQAEANPLVMKASTTNPKTWLKTLTDFYNRYYQSSYGTQAGTWLFNTTKSIAAANSAITVTQFTHSFNQPSIITRIPGTTSDLVIVSAHYDSTGGSSTARGPGADDNGSGVVVLLEALRVLANAGFKPKNTLEFHFYSGEEGGLLGSQAVFSSYKSSGKKVLAVINQDMAGYSPSGKISIYTDYVDSALTAYTRVVATAYTGATTSDTCGYGCSDHASARSNGFPAAYVCDERMDASSPYIHSSGDAYSTIMWDAVLRHTKFTVAFLVEASYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PIC6</accession>
    <name>A0AAN6PIC6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">alpha-amylase</fullName>
            <ecNumber evidence="4">3.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">C8A01DRAFT_34720</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1-&gt;4)-alpha-linked D-glucose units.</text>
            <dbReference type="EC" id="3.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.1" evidence="4"/>
    <dbReference type="EMBL" id="MU854361">
        <property type="protein sequence ID" value="KAK4041202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PIC6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11319">
        <property type="entry name" value="AmyAc_euk_AmyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000120">
        <property type="entry name" value="Alpha-amylase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013777">
        <property type="entry name" value="A-amylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015340">
        <property type="entry name" value="A_amylase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF208">
        <property type="entry name" value="ALPHA-AMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09260">
        <property type="entry name" value="A_amylase_dom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001024">
        <property type="entry name" value="Alph-amyl_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042987084" description="alpha-amylase" evidence="16">
        <location>
            <begin position="23"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="17">
        <location>
            <begin position="35"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="12">
        <location>
            <position position="230"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="12">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="368"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="13">
        <location>
            <position position="321"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="52"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="174"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="264"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="462"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAK4041202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="534" mass="58314" checksum="8CC9F8CD4D8106A4" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PJ31</accession>
    <name>A0AAN6PJ31_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_16039</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854385">
        <property type="protein sequence ID" value="KAK4040066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PJ31"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF79">
        <property type="entry name" value="C6 FINGER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="55"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="690"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="778"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="711"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="793"/>
            <end position="803"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4040066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="869" mass="96785" checksum="BE616813F09A6AC4" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PJD8</accession>
    <name>A0AAN6PJD8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein Asterix</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_45173</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854352">
        <property type="protein sequence ID" value="KAK4041742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PJD8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045048">
        <property type="term" value="P:protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005351">
        <property type="entry name" value="ASTER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28038">
        <property type="entry name" value="ADL329WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28038:SF1">
        <property type="entry name" value="ADL329WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03669">
        <property type="entry name" value="ASTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4041742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="116" mass="12435" checksum="EFD93C31CED32DE8" modified="2024-10-02" version="1">MEFSKEKDMRQPDLIIPYQEPAAKGDNVELQSTVSSTLPMAAVFLRNKYVGWAAVVFSLQSWLGESEETKKSSSTPGYFNVGMSVVSLLVTYLPIFLPQPGANVGSPTGAPAPAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PJR5</accession>
    <name>A0AAN6PJR5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_14102</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854343">
        <property type="protein sequence ID" value="KAK4042273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PJR5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042862887" evidence="2">
        <location>
            <begin position="23"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4042273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="240" mass="26271" checksum="171C73BC1E21AAEC" modified="2024-10-02" version="1">MGLTRSLLLPIGLVLFLLAVDAAITMGLVSSMVSFLHHRGRGPFAVAPPDGSPFLLAGLPANLVVNQGHTTNAAAGTALILVGFGGSIALWLERRARKKWDRSSACFYIWAVVVLLSWLLTLVALVYTFVETAKTAGQAVDLAVARANPPPAHYPDGRWTPENWYAAVRGLPLASADQRRVIGGYLTIMRGWRWNLVPMFILGFVLLGLVVLEVLRTRRRDFQRVSMVEVLAEPFKRASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PJU3</accession>
    <name>A0AAN6PJU3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Glyceraldehyde-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="12">1.2.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">C8A01DRAFT_46175</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = (2R)-3-phospho-glyceroyl phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10300"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="1.2.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 12">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.12" evidence="12"/>
    <dbReference type="EMBL" id="MU854376">
        <property type="protein sequence ID" value="KAK4040456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PJU3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004365">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18126">
        <property type="entry name" value="GAPDH_I_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05214">
        <property type="entry name" value="GAPDH_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000001">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000020">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020830">
        <property type="entry name" value="GlycerAld_3-P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006424">
        <property type="entry name" value="Glyceraldehyde-3-P_DH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01534">
        <property type="entry name" value="GAPDH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836">
        <property type="entry name" value="GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836:SF76">
        <property type="entry name" value="GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00044">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000149">
        <property type="entry name" value="GAP_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00078">
        <property type="entry name" value="G3PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00071">
        <property type="entry name" value="GAPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 9 12" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding" evidence="13">
        <location>
            <begin position="3"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="12"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="150"/>
            <end position="152"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="210"/>
            <end position="211"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Activates thiol group during catalysis" evidence="10">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK4040456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="337" mass="36005" checksum="83DD1BA40FF7250B" modified="2024-10-02" version="1">MAVKVGINGFGRIGRIVFRNAVEHDDVEVVAVNDPFIDPKYAEYMLKYDSTHGTFNGTIAVEGSDLVVNGKKVKFYTERDPAAIPWKDTGAEYIVESTGVFTTTEKAGAHLKGGAKRVIISAPSADAPMYVMGVNEKTYDGKAQVISNASCTTNCLAPLAKVVNDKFGLVEGLMTTVHAYTATQKTVDGPSAKDWRGGRAAAQNIIPSSTGAAKAVGKVIPELNGKLTGMSLRVPTSNVSVVDLTCRLEKGASYDEIKAALKEAAEGPLKGILAYTEDEIVSSDLKGHNASSIFDAKAGISLNKNFVKLVSWYDNEWGYSRRVLDLLAYVAKVDAGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PKJ5</accession>
    <name>A0AAN6PKJ5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_13708</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854337">
        <property type="protein sequence ID" value="KAK4042693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PKJ5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF31">
        <property type="entry name" value="LAEA-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G01930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="334"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4042693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="355" mass="40520" checksum="42814896B7E2663C" modified="2024-10-02" version="1">MADQQSPENVIQPDERWDNASVDDDEGAEVASSGSSLTSITSSVLHGRVEDGRVYAVYGKEEYGMPMDDVELDRIDMCHAKYFALLEKKRFIAPIAENPQKILDLGCGTGIWSIDVADMYPSADVLGVDIAATQPEWVPPNCRFELDDIEQEWAWRENSFDFVFARDLILAIRDWPRLVDQIYTHLKPGGWAEFHCVTGLLRCDDNTLPEDSPMRKFADALYESTKIFGTPIDDPTRWKGWFEDRGYDDVTEVVYKMPCNPWPKDQRLKLIGAFEMENLLYGLSGMVTRLFVKALKWSPEQVQVFLVDVRREIKNRNLHVYWPYYVVYARKPGGSSSTEKARSSVPKTVPEPSAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PKR3</accession>
    <name>A0AAN6PKR3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_46339</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854380">
        <property type="protein sequence ID" value="KAK4040270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PKR3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042889143" evidence="1">
        <location>
            <begin position="18"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4040270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="177" mass="19518" checksum="418B53233BB3740C" modified="2024-10-02" version="1">MRALLTLLCLFTALTSATITFTLQRANNPTTDQSDAYTRIQAAVSKAVARYNRLATRPNKSLTIQYVPSVQTADGSFNGNIRFGSNRAYMNERTALHEISHTLGIGQTRAFDDRCKANNWPSATRLLQSWDGQSAKINCGGGHIWPYGLNYDNEMSETNAERHCKLIDAMLADGLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PLA8</accession>
    <name>A0AAN6PLA8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">C8A01DRAFT_44976</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 12">Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854348">
        <property type="protein sequence ID" value="KAK4041998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PLA8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006386">
        <property type="term" value="P:termination of RNA polymerase III transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10509">
        <property type="entry name" value="Zn-ribbon_RPC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000005">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012164">
        <property type="entry name" value="Rpa12/Rpb9/Rpc10/TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001529">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034014">
        <property type="entry name" value="Zn_ribbon_RPC11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239:SF12">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02150">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005586">
        <property type="entry name" value="RNApol_RpoM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00661">
        <property type="entry name" value="RPOL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8 12" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3 9 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS-type" evidence="13">
        <location>
            <begin position="67"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="10">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="6"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
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        </ligand>
    </feature>
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        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
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        </ligand>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
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        <source>
            <dbReference type="RuleBase" id="RU003474"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK4041998.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="111" mass="12693" checksum="B9FD7976EFEABDC3" modified="2024-10-02" version="1">MPILFCPYCANLLILSRMDTGGNRLECRTCPYQHAIDMPIFSRKNFPRKEKEDVFGGPGAWDNAQKGRVQCPTANCNGDEAAFFQVQIRSADEPMTTFYKCMTCGNRWREN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PLC2</accession>
    <name>A0AAN6PLC2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_15000</name>
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        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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            <end position="838"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="398"/>
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            <end position="444"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="895" mass="97304" checksum="B2D32C6015BBE3AF" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">C8A01DRAFT_45312</name>
    </gene>
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        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
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            <taxon>Sordariomycetidae</taxon>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPP4R2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854355">
        <property type="protein sequence ID" value="KAK4041566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:protein phosphatase 4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="F:protein phosphatase regulator activity"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="PPP4R2"/>
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        <property type="entry name" value="PPP4R2-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN PHOSPHATASE 4 REGULATORY SUBUNIT 2-RELATED"/>
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        <property type="entry name" value="PPP4R2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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        <location>
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            <end position="104"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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            <end position="580"/>
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            <end position="367"/>
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    </feature>
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    <feature type="compositionally biased region" description="Low complexity" evidence="2">
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            <begin position="561"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009207"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4041566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="580" mass="59404" checksum="A3006D8322DA255A" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PMI3</accession>
    <name>A0AAN6PMI3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycosyl hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_34422</name>
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    <organism evidence="3 4">
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        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
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                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854355">
        <property type="protein sequence ID" value="KAK4041581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PMI3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053169">
        <property type="entry name" value="MUG_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47791:SF2">
        <property type="entry name" value="ENDO MANNANASE, GH76 FAMILY (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47791">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 191 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042830962" description="Glycosyl hydrolase" evidence="2">
        <location>
            <begin position="18"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="495"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="532"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="557"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4041581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="609" mass="65883" checksum="67B65DCDFAD919A3" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PMK5</accession>
    <name>A0AAN6PMK5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_43305</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854324">
        <property type="protein sequence ID" value="KAK4043736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PMK5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001666">
        <property type="entry name" value="MDS1 and EVI1 complex locus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF58">
        <property type="entry name" value="ZINC FINGER PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="373"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="401"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="423"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="28"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="68"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="109"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="129"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="175"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="192"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="268"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="445"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4043736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="467" mass="47432" checksum="282217D70761CDCD" modified="2024-10-02" version="1">MTTIPSDGSLGARPASPVAGAAPPLPSLNPSSIPAPLSSSTDSTKTSTAPSPSVLTPPGAVSDGYPTSGPHAGHSHSSQPGGQSLYYAGHMTGSWPTPGLSQPSAYTYGHSSSGASGPGSLAQPPYHRAPASYGSAPSPSHQHFPGRASSSAPNGESIPAPQSYQDQQSFSSPVGVGGPGSGRGGGLGSPLNPQGGNQQSGLAQPMLSNPAQTTAHQGPGQSTPGGGPVTTQDGGSYRPPVTAAHYYPQTSAPQQPSFPSYASPVTQPSPTSALSASSSGSIPRAAIPAMAPPLQYPAGRGHPVPSMGSYASYNPVPGPVLSNMHHPGAPLTMVTGMSGLPNYSHHPGMPPHHPHSLYLHHPGGPAPQSERPFKCDICQQAFNRNHDLKRHQRIHLAVKPFGCGDCEKRFSRKDALKRHRLVKGCGGTSPLEGPKTATGGNEGASDDRGVAVGGDRDGSPRSIKKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PML4</accession>
    <name>A0AAN6PML4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2-dehydropantoate 2-reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_12706</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854324">
        <property type="protein sequence ID" value="KAK4043751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PML4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000017">
        <property type="entry name" value="2-dehydropantoate 2-reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000424">
        <property type="entry name" value="Meiotically up-regulated gene 72 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051402">
        <property type="entry name" value="KPR-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708">
        <property type="entry name" value="PROBABLE 2-DEHYDROPANTOATE 2-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708:SF25">
        <property type="entry name" value="PROTEIN PAM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketopantoate reductase N-terminal" evidence="2">
        <location>
            <begin position="10"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Ketopantoate reductase C-terminal" evidence="3">
        <location>
            <begin position="200"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="475"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="622"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="367"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="396"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="486"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="676"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="738"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="749"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="759"/>
            <end position="776"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4043751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="785" mass="84587" checksum="1743CD5A2D2AC610" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PMN4</accession>
    <name>A0AAN6PMN4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_32100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854324">
        <property type="protein sequence ID" value="KAK4043781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PMN4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="556"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="607"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="358"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="573"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="609"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4043781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="776" mass="84210" checksum="FC7E31C6DF0D8A0D" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PMN5</accession>
    <name>A0AAN6PMN5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FAD dependent oxidoreductase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_45198</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854353">
        <property type="protein sequence ID" value="KAK4041656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PMN5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF150">
        <property type="entry name" value="OXIDOREDUCTASE TDA3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="3">
        <location>
            <begin position="9"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4041656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="443" mass="47642" checksum="1CEE70BD084ABBAB" modified="2024-10-02" version="1">MNAQRKRNIVIVGGGIIGSSTAYYISRHPRFNPALHTVTLLEATSIAAGASGKAGGLLALWAYPTCLVPLSYALHRDLAAKHNGAERWGYRRLGCGSLAATVSKNGIETRAPKPPSPPADNGTNGELPIQSTVPDEKTKDWEKLPKQDGNAAGLLQDSPLPPDLDWIDGRLIQHYEEMGSPGATETAQVHPFYFTNAMADLAREKGVDIRLRAKVTKINDTKTAGVHSVAYEDRDTGKTHTIGDVTDVIVAAGPWTGKLVPRTKVEGLRAHSVVFEADVSPYAVFTDIQLPTDYIPEHRASQGQKRRHKGNVDPEIYARPFGEVYACGEPDKTIPLPATADEVSTDESQCDDLIAYIGTISPALASAPVKARQACYLPQHIRFGEQRGPLIGPTSVPGLWVAAGHTCWGIQNGPGTGYLMAGMIFGDGVEEEVGSLDPRKFKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PMR4</accession>
    <name>A0AAN6PMR4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">glycerol-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="4">1.1.5.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">C8A01DRAFT_43556</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.5.3" evidence="4"/>
    <dbReference type="EMBL" id="MU854326">
        <property type="protein sequence ID" value="KAK4043617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PMR4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004368">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.870:FF:000001">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.870">
        <property type="entry name" value="Alpha-glycerophosphate oxidase, cap domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031656">
        <property type="entry name" value="DAO_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038299">
        <property type="entry name" value="DAO_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000447">
        <property type="entry name" value="G3P_DH_FAD-dep"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985:SF15">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16901">
        <property type="entry name" value="DAO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01001">
        <property type="entry name" value="FADG3PDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00978">
        <property type="entry name" value="FAD_G3PDH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="13">
        <location>
            <begin position="83"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-glycerophosphate oxidase C-terminal" evidence="14">
        <location>
            <begin position="497"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF16901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK4043617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="681" mass="75423" checksum="32172052C7690629" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PN56</accession>
    <name>A0AAN6PN56_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Nicotinamide-nucleotide adenylyltransferase</fullName>
            <ecNumber evidence="17">2.7.7.1</ecNumber>
            <ecNumber evidence="17">2.7.7.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">C8A01DRAFT_32734</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Can also use GTP and ITP as nucleotide donors. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, can use NAD(+), NADH, NaAD, nicotinic acid adenine dinucleotide phosphate (NHD), nicotinamide guanine dinucleotide (NGD) as substrates. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+). Protects against axonal degeneration following injury. May be involved in the maintenance of axonal integrity. Also functions as a stress-response chaperone protein that prevents toxic aggregation of proteins; this function may be independent of its NAD(+) synthesis activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 17">
            <text>beta-nicotinamide D-ribonucleotide + ATP + H(+) = diphosphate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:21360"/>
            <dbReference type="ChEBI" id="CHEBI:14649"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="EC" id="2.7.7.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 17">
            <text>nicotinate beta-D-ribonucleotide + ATP + H(+) = deamido-NAD(+) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22860"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="EC" id="2.7.7.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from nicotinamide D-ribonucleotide: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; NAD(+) biosynthesis; deamido-NAD(+) from nicotinate D-ribonucleotide: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 17">Belongs to the eukaryotic NMN adenylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.1" evidence="17"/>
    <dbReference type="EC" id="2.7.7.18" evidence="17"/>
    <dbReference type="EMBL" id="MU854331">
        <property type="protein sequence ID" value="KAK4043095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PN56"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000309">
        <property type="term" value="F:nicotinamide-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004515">
        <property type="term" value="F:nicotinate-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09286">
        <property type="entry name" value="NMNAT_Eukarya"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000221">
        <property type="entry name" value="Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051182">
        <property type="entry name" value="Euk_NMN_adenylyltrnsfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005248">
        <property type="entry name" value="NadD/NMNAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045094">
        <property type="entry name" value="NMNAT_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00482">
        <property type="entry name" value="nicotinate (nicotinamide) nucleotide adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12039">
        <property type="entry name" value="NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12039:SF0">
        <property type="entry name" value="NICOTINAMIDE-NUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12 17" id="KW-0520">NAD</keyword>
    <keyword evidence="10 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 17" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7 17" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="19">
        <location>
            <begin position="51"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="271"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00093425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU362021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAK4043095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="297" mass="32758" checksum="1DADC3622262DE5C" modified="2024-10-02" version="1">MTAETIDSGTQTPSALMEQPTLDGAQAPYTFPTQKLKRRTTQPGKTPLVLVACGSFSPITFLHLRMFEMAGDFVRFNTDFEVCAGYLSPVSDAYKKVGLAPGSHRVNMCARAVAQSSWLMVDPFETVNCNEKGEPQYVPTAKVLRHFDHEINTVLGGIEGTDGKMRKARIALLAGADLVMSMGEPGLWAPRDLDTILSSYGAFIIERSGTDIDEALASLRQYENNIWVISQVIQNDISSTKVRLFLKKDLSVRYLIPDPVVEYIDEHQLFSEPNPNKSRSRTPDVVPGPSNTKSTKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PNF6</accession>
    <name>A0AAN6PNF6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">NADH-ubiquinone oxidoreductase 51 kDa subunit, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">C8A01DRAFT_44601</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29091"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.1.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="14">Complex I is composed of about 40 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the complex I 51 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854342">
        <property type="protein sequence ID" value="KAK4042344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PNF6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1440.230:FF:000001">
        <property type="entry name" value="Mitochondrial NADH dehydrogenase flavoprotein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.600:FF:000001">
        <property type="entry name" value="NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11540:FF:000001">
        <property type="entry name" value="NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="entry name" value="Flavin prenyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11540">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 51kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.230">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050837">
        <property type="entry name" value="ComplexI_51kDa_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001949">
        <property type="entry name" value="NADH-UbQ_OxRdtase_51kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011537">
        <property type="entry name" value="NADH-UbQ_OxRdtase_suF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011538">
        <property type="entry name" value="Nuo51_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037225">
        <property type="entry name" value="Nuo51_FMN-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019575">
        <property type="entry name" value="Nuop51_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037207">
        <property type="entry name" value="Nuop51_4Fe4S-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054765">
        <property type="entry name" value="SLBB_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01959">
        <property type="entry name" value="nuoF_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010120">
        <property type="entry name" value="PRK13596.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11780:SF10">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11780">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE FLAVOPROTEIN 1 NDUFV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01512">
        <property type="entry name" value="Complex1_51K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10589">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22461">
        <property type="entry name" value="SLBB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00928">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="Homo-oligomeric flavin-containing Cys decarboxylases, HFCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142019">
        <property type="entry name" value="Nqo1 FMN-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142984">
        <property type="entry name" value="Nqo1 middle domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140490">
        <property type="entry name" value="Nqo1C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140860">
        <property type="entry name" value="Pseudo ankyrin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00645">
        <property type="entry name" value="COMPLEX1_51K_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0288">FMN</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0520">NAD</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <feature type="domain" description="NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding" evidence="17">
        <location>
            <begin position="1060"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="551"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="588"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="625"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00063883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00072764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAK4042344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1177" mass="130962" checksum="AB5D637B424DA282" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PNP7</accession>
    <name>A0AAN6PNP7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_43719</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854328">
        <property type="protein sequence ID" value="KAK4043410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PNP7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="709"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="782"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="709"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="788"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="798"/>
            <end position="829"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4043410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="829" mass="90166" checksum="06B23C10CB5CED0E" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PP70</accession>
    <name>A0AAN6PP70_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Saccharopine dehydrogenase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_42517</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the saccharopine dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854317">
        <property type="protein sequence ID" value="KAK4044606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PP70"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009247">
        <property type="term" value="P:glycolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000592">
        <property type="entry name" value="Similar to saccharopine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051276">
        <property type="entry name" value="Saccharopine_DH-like_oxidrdct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12286">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12286:SF5">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="290"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="Saccharopine dehydrogenase NADP binding" evidence="3">
        <location>
            <begin position="11"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4044606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="417" mass="44793" checksum="971BABC5D6A7FF4C" modified="2024-10-02" version="1">MPSKHDRQYDVVVFGATGYTGKYTAQYITTHLPTDLKWAVAGRSQSKLEDVVAECKAVNADRAQPGIEICNLTDADLAALAKKTFILITTVGPYGKLGEHAFKACAENGTHYLDVTGEVPFVAKMLKKYQAAAQASGALMFPQIGIESAPPDLVTWSLASFIRSEFSSPTADVTVSIHNLKSAPSGGTLTTALTILENFTLSDLRAAYAPYSLSPLPRPATNPSKPSLLTRLTGLVSIPSLGLLTTSPAGGTDAAIVQRTWGLLGSVPSRTAQFYGPHFSFREYMRPRNWLTGIAVHCGLMVLGLVMVTPWLRRVVARWVYQPGEGPEAGVASGDEIEYRGIGRRDGGGGERVVCRAGFRGSVYYLTGILLAEAASTLLEEDVELPGGLYTAACLGQPLIDRLERGGFHIETKRLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PPA8</accession>
    <name>A0AAN6PPA8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Magnesium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_43309</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854324">
        <property type="protein sequence ID" value="KAK4043740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PPA8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3730.20:FF:000012">
        <property type="entry name" value="DUF803 domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF86">
        <property type="entry name" value="ADR321CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="287"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="317"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="357"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="335"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="385"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="425"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="525"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="551"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4043740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="592" mass="63949" checksum="133368463E50DEEF" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PQ24</accession>
    <name>A0AAN6PQ24_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Glucose inhibited division protein A-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">C8A01DRAFT_43830</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the MSS1-MTO1 complex that catalyzes the 5-carboxymethylaminomethyluridine (cmnm(5)U) modification at the 34th wobble position (U34) of mitochondrial tRNAs.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MnmG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854330">
        <property type="protein sequence ID" value="KAK4043184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PQ24"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070899">
        <property type="term" value="P:mitochondrial tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04496">
        <property type="entry name" value="SSB_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000145">
        <property type="entry name" value="tRNA uridine 5-carboxymethylaminomethyl modification enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.570:FF:000001">
        <property type="entry name" value="tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000002">
        <property type="entry name" value="tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.570">
        <property type="entry name" value="GidA associated domain, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00129">
        <property type="entry name" value="MnmG_GidA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049312">
        <property type="entry name" value="GIDA_C_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004416">
        <property type="entry name" value="MnmG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002218">
        <property type="entry name" value="MnmG-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020595">
        <property type="entry name" value="MnmG-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026904">
        <property type="entry name" value="MnmG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047001">
        <property type="entry name" value="MnmG_C_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044920">
        <property type="entry name" value="MnmG_C_subdom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040131">
        <property type="entry name" value="MnmG_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000424">
        <property type="entry name" value="Primosome_PriB/ssb"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00136">
        <property type="entry name" value="mnmG_gidA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806">
        <property type="entry name" value="GLUCOSE INHIBITED DIVISION PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806:SF0">
        <property type="entry name" value="PROTEIN MTO1 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01134">
        <property type="entry name" value="GIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21680">
        <property type="entry name" value="GIDA_C_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13932">
        <property type="entry name" value="SAM_GIDA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00436">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01228">
        <property type="entry name" value="GIDA_assoc_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01280">
        <property type="entry name" value="GIDA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01281">
        <property type="entry name" value="GIDA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50935">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain" evidence="10">
        <location>
            <begin position="714"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="654"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="654"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00054993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK4043184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="842" mass="91640" checksum="F5FCC372D21A6783" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PRP5</accession>
    <name>A0AAN6PRP5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Alanine--tRNA ligase</fullName>
            <ecNumber evidence="15">6.1.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Alanyl-tRNA synthetase</fullName>
            <shortName evidence="15">AlaRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">ALA1</name>
        <name evidence="17" type="ORF">C8A01DRAFT_12851</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14 15">Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 15">
            <text>tRNA(Ala) + L-alanine + ATP = L-alanyl-tRNA(Ala) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:12540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:9923"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78497"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="15">Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.7" evidence="15"/>
    <dbReference type="EMBL" id="MU854325">
        <property type="protein sequence ID" value="KAK4043696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PRP5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070143">
        <property type="term" value="P:mitochondrial alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00673">
        <property type="entry name" value="AlaRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.130:FF:000004">
        <property type="entry name" value="Alanine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.310.40:FF:000003">
        <property type="entry name" value="Alanine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000011">
        <property type="entry name" value="Alanine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.980.10:FF:000004">
        <property type="entry name" value="Alanine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00036_B">
        <property type="entry name" value="Ala_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002318">
        <property type="entry name" value="Ala-tRNA-lgiase_IIc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018162">
        <property type="entry name" value="Ala-tRNA-ligase_IIc_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050058">
        <property type="entry name" value="Ala-tRNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059090">
        <property type="entry name" value="ALA1_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023033">
        <property type="entry name" value="Ala_tRNA_ligase_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00344">
        <property type="entry name" value="alaS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11777:SF9">
        <property type="entry name" value="ALANINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11777">
        <property type="entry name" value="ALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26023">
        <property type="entry name" value="ALA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00980">
        <property type="entry name" value="TRNASYNTHALA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101353">
        <property type="entry name" value="Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 15" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 15 17" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 15" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 15" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="7 15" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alanyl-transfer RNA synthetases family profile" evidence="16">
        <location>
            <begin position="113"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="706"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="710"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="825"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="829"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00055137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAK4043696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1066" mass="119186" checksum="82931E44A789C024" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PRS0</accession>
    <name>A0AAN6PRS0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proteophosphoglycan ppg4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_32044</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854324">
        <property type="protein sequence ID" value="KAK4043726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PRS0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="418"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="766"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="826"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="898"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="959"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="442"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="472"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="514"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="613"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="770"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="847"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="959"/>
            <end position="975"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4043726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1113" mass="119270" checksum="1C6F2EF48ED136C5" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PS84</accession>
    <name>A0AAN6PS84_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Enolase</fullName>
            <ecNumber evidence="4">4.2.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">2-phospho-D-glycerate hydro-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">2-phosphoglycerate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">C8A01DRAFT_43403</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(2R)-2-phosphoglycerate = phosphoenolpyruvate + H2O</text>
            <dbReference type="Rhea" id="RHEA:10164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.2.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the enolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.11" evidence="4"/>
    <dbReference type="EMBL" id="MU854325">
        <property type="protein sequence ID" value="KAK4043645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000015">
        <property type="term" value="C:phosphopyruvate hydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004634">
        <property type="term" value="F:phosphopyruvate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03313">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13981">
        <property type="entry name" value="STKc_Bub1_BubR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.430:FF:000003">
        <property type="entry name" value="Checkpoint serine/threonine-protein kinase BUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.10:FF:000001">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.120:FF:000002">
        <property type="entry name" value="Enolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="entry name" value="Enolase-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="entry name" value="Enolase-like, N-terminal domain"/>
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    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00318">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000941">
        <property type="entry name" value="Enolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020810">
        <property type="entry name" value="Enolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020809">
        <property type="entry name" value="Enolase_CS"/>
    </dbReference>
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        <property type="entry name" value="Enolase_N"/>
    </dbReference>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013212">
        <property type="entry name" value="Mad3/Bub1_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01060">
        <property type="entry name" value="eno"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902:SF1">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00113">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03952">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08311">
        <property type="entry name" value="Mad3_BUB1_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00148">
        <property type="entry name" value="ENOLASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00002">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00178">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00001">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01192">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01193">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00777">
        <property type="entry name" value="Mad3_BUB1_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="Enolase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="Enolase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51489">
        <property type="entry name" value="BUB1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00164">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BUB1 N-terminal" evidence="14">
        <location>
            <begin position="497"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="1244"/>
            <end position="1601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="670"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="917"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1266"/>
            <end position="1289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="670"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="937"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="952"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="1097"/>
            <end position="1113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK4043645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1601" mass="176830" checksum="081AF1C9BCAF94A5" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PST2</accession>
    <name>A0AAN6PST2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SMP-30/Gluconolactonase/LRE-like region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_12608</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854323">
        <property type="protein sequence ID" value="KAK4043915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PST2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052998">
        <property type="entry name" value="Hetero-Diels-Alderase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42060:SF1">
        <property type="entry name" value="NHL REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42060">
        <property type="entry name" value="NHL REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042830177" description="SMP-30/Gluconolactonase/LRE-like region domain-containing protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4043915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="362" mass="37637" checksum="B442A0710942BD95" modified="2024-10-02" version="1">MVLRPGHILSAAVATLAAATAVSAAACCSGAKLPLPVKTVYQFDTETWIENLAVRPNGNLLLVVDENVTSPEHPVSLYQLANPASTQPELSLVYAFPLGTVLGITELQPEVYAVLAENFTGSFEAVPGTSKMFTFNFNDMDGGQPAMKEVATLPNTISGPDGIAALPGHPDTVLVADMYASLVWAVDITMGTTTVFAQTPEMAEVHNATKMGINGLRVSDSYLYFTNSDLKSVFRLPLDACGSGVGPAAEMVANLTAVSPVFIDDFTIGRDGTLWVTSSGPQNVVVAVRPDGKGGFLEPVVAAGAIDSTAVQGDVGAAFGRGPLDRDVLYVVTNGGLWGAGLGLNQTATEPGKVAAVDTRCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PSW9</accession>
    <name>A0AAN6PSW9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Carbonic anhydrase</fullName>
            <ecNumber evidence="2 10">4.2.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 10">Carbonate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">C8A01DRAFT_31580</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Reversible hydration of carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>hydrogencarbonate + H(+) = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the beta-class carbonic anhydrase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="2 10"/>
    <dbReference type="EMBL" id="MU854320">
        <property type="protein sequence ID" value="KAK4044266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PSW9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015976">
        <property type="term" value="P:carbon utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071244">
        <property type="term" value="P:cellular response to carbon dioxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00883">
        <property type="entry name" value="beta_CA_cladeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1050.10:FF:000001">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1050.10">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001765">
        <property type="entry name" value="Carbonic_anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015892">
        <property type="entry name" value="Carbonic_anhydrase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036874">
        <property type="entry name" value="Carbonic_anhydrase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11002">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11002:SF76">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00484">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00947">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53056">
        <property type="entry name" value="beta-carbonic anhydrase, cab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00705">
        <property type="entry name" value="PROK_CO2_ANHYDRASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 10" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601765-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK4044266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="234" mass="24674" checksum="F00D3732D4CCE0B6" modified="2024-10-02" version="1">MAQEDSFLYALSSNNAWAGYKAHQNPSFFPKLASGQSPQILWLGCSDSRCPETTILGLQPGDVFVHRNIANIISPTDINTSAVIEYAVVHLKVKHVVLCGHTACGGAIAALADGRVGGVLDTWLTPLRAVRLAHAEELAGIKDDAARAVRIAELNVEAGVRVLMANGVIQDAVRERGLEVHGCLFEIGCGRIKDLGFGTKGGSRGVVAAGGGEEVRGRHAQLVFRGGNASMAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PTV7</accession>
    <name>A0AAN6PTV7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_30955</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854316">
        <property type="protein sequence ID" value="KAK4044776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PTV7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="83"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="164"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4044776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="312" mass="32341" checksum="CFEE8BAF2E1FE141" modified="2024-10-02" version="1">MDFLKGAKSPSSESLLPVDAREKTATGTQSTDNRQRPASASKMAYARRTILVLFVCMLVLLGIASAGPRMPCHKGTTGQQTTAESSESSSFSARLKSASPSSLHDLLHRYFPGRFRDGVFESEHKAMEGVHSANPALATSILQLTKRDDTNSTATSASQPPPASETQTSDPPSETPSTTIIPPTSSSSIVEPSSTSSVPPSTTSSSRSSTPTPAPSSSLPETTLTTTTKPLSTTSSPPRTSKETTETYTSTSPNGAVVVVTRTNFVPADGAETPAPTSTGRPATLQNAAVRRHSGVSALAGVVGLAVLLLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SL96</accession>
    <name>A0AAN6SL96_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_42056</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854785">
        <property type="protein sequence ID" value="KAK4031498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SL96"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4031498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="174" mass="19615" checksum="EFDFD8B5486032B1" modified="2024-10-02" version="1">MQPQLSCRIGGKRLVSLMPTLLQQIWRSPGGSRAWTLQEALLSPRTAIGQRPPAQHRRPEKGAWLASRVGDGCLRTPIDITSQRLERYGSKLTLYSYRRMTDQADGLNAFSGILSFLRRMYTGGFHNGLPLEDFQWGFVYHHLLQLASGQDGLATRRTVVSLIVPEQRLAVLQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SMX8</accession>
    <name>A0AAN6SMX8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2293 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_40387</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854548">
        <property type="protein sequence ID" value="KAK4033163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SMX8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018744">
        <property type="entry name" value="DUF2293"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38113">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38113:SF2">
        <property type="entry name" value="DUF2293 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10056">
        <property type="entry name" value="DUF2293"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2293" evidence="2">
        <location>
            <begin position="95"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4033163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="327" mass="36732" checksum="37B354D91C6E9EBD" modified="2024-10-02" version="1">MNTDEPEVRPHDALPKGYSFVPKGNVYITKNCRKKTHEAEKTLYVVVDKTGKPMGLRCPTYIHNAVMSEDKATASQRAQAVQKRDTAIEENFEEAIVKLFPEIPKTSIPQIFGHALKKHSRRVGRAGTVELQARVKLAVRAHIRHVHTDYDLLLKQGASRSVARDKVWEKLNEVARRWGGRPLKSATAVPVEGRRGKKSKTVAPAGKKTRTNAAAKKAVVHTAQRTTRRMSREALELSLPTFLPAPQANPGHAVLRVHTRRMTSELVEAENEEMVMVEELDADVNGFLEDVDARDAVFTRGEETSDYDSDGSEWSNWSDVRPKKWVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SNM2</accession>
    <name>A0AAN6SNM2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribonuclease P protein subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_18244</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic/archaeal RNase P protein component 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854457">
        <property type="protein sequence ID" value="KAK4035051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SNM2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030677">
        <property type="term" value="C:ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033204">
        <property type="term" value="F:ribonuclease P RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.210:FF:000005">
        <property type="entry name" value="Ribonuclease P protein subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.210">
        <property type="entry name" value="Ribonuclease P/MRP, subunit p29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00754">
        <property type="entry name" value="RNase_P_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016848">
        <property type="entry name" value="RNase_P/MRP_Rpp29-subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036980">
        <property type="entry name" value="RNase_P/MRP_Rpp29_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023538">
        <property type="entry name" value="RNP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023534">
        <property type="entry name" value="Rof/RNase_P-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002730">
        <property type="entry name" value="Rpp29/RNP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13348:SF0">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13348">
        <property type="entry name" value="RIBONUCLEASE P SUBUNIT P29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01868">
        <property type="entry name" value="RNase_P-MRP_p29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF027081">
        <property type="entry name" value="RNase_P/MRP_p29_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00538">
        <property type="entry name" value="POP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101744">
        <property type="entry name" value="Rof/RNase P subunit-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="34"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR027081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4035051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="234" mass="26329" checksum="11D62ABF1F44AE92" modified="2024-10-02" version="1">MDPKPKKDQPIAAILLARAHDPDEATRIFTEKVQQRPLFLAPSSPPPSDARAARRRAQEKKKQQRKKALKPRPLSSTQRRRLGLYDVPRAGQRHALFEPLHQLWLGYVREILGSEAYTGGEGAAAKLASADFHGAGVEVVRSGCVSRVGIKGIVVKDSKFAFEIVTRRDRVKLVPKEGTVFRFEVPVPDLRPKEGGGQAQEMSRMVFEIHGEQFQFRSADRASRKFRSHFSKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SNR7</accession>
    <name>A0AAN6SNR7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_39611</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854503">
        <property type="protein sequence ID" value="KAK4033915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SNR7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019180">
        <property type="entry name" value="Oxidoreductase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039251">
        <property type="entry name" value="OXLD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21193">
        <property type="entry name" value="OXIDOREDUCTASE-LIKE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21193:SF3">
        <property type="entry name" value="OXIDOREDUCTASE-LIKE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09791">
        <property type="entry name" value="Oxidored-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidoreductase-like" evidence="2">
        <location>
            <begin position="232"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="145"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4033915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="386" mass="40984" checksum="5A2DC1F4110F39D5" modified="2024-10-02" version="1">MRRTFLSARPARAVYRALGSQQPRRTFATPPIKADSPPSPIEPSKEQAHPVGPFYEAILRTPAPLPEKKPEEPPVTSQASPAQPPKPTPEQQQQPSKPADEAKPAAPAAEDKPSPQPAAEDKKPARRPRKPRQPAAETTAPKTKSVPSSSSSSASLDSFPPSPGPTLLPQSPPPPPNQTSNPSPEEEAQAQEENPPSNALQARARIVFGASLAGPAERAERLARLRSDSRLVAGVLVPPKPDEPDNCCMSGCVNCVWDRYRDEMEAWAEGNAEAERRLAAAGVGAAVGVTEECMEGVGHDVDLGVHDADVDRGAVGVDDDGGGSVGNWEASSAPAGVNRDGGGRVAAAKAFWDEELYKNVPVGIREFMKQEKRLKEKHLREGTVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SNZ4</accession>
    <name>A0AAN6SNZ4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_39398</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854493">
        <property type="protein sequence ID" value="KAK4034140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SNZ4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.750:FF:000013">
        <property type="entry name" value="Similar to TBC domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000034">
        <property type="entry name" value="TBC (Tre-2/Bub2/Cdc16) domain family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053949">
        <property type="entry name" value="SBE2/SBE22_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF15">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 12 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22874">
        <property type="entry name" value="SBE2_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="474"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="166"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4034140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="753" mass="82442" checksum="0445A64B62E80D99" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SP07</accession>
    <name>A0AAN6SP07_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_49254</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854483">
        <property type="protein sequence ID" value="KAK4034362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SP07"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4034362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="265" mass="29889" checksum="51A8F3A10A76A09A" modified="2024-10-02" version="1">MAILNQVSRRKRATALKDSRAGTSDEIEGEGALQSLAQPQQYKGTPNIASYHNRTAIVKFLPFMLASLDTRLQRNQRREKHKVLQVLRIEDRHLIERWAAELCAALDHLKLTDFDCVARIGDASYSNAPPWARLYPDPLTGKGRWGLYGPKTEQFAIGSLLYCMTRGHEPYGHPEEDNPELDVVRLFKEGVFPRVNAEGDVLDCIIDRCWAGWYESIKDLAEAAAQLLAAVDMSAATTFSTEYCAQKRNKCCRLIQKGLLEMYGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SPW7</accession>
    <name>A0AAN6SPW7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_18059</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854450">
        <property type="protein sequence ID" value="KAK4035248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SPW7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043024851" evidence="2">
        <location>
            <begin position="22"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="218"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="366"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4035248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="428" mass="43339" checksum="A420001B03791AAC" modified="2024-10-02" version="1">MAPVGYPSLLLVLLQACRVMSLPQGVTDPVQPSCFPTTTTVYGIPTAITDFGSFISSMNSQYSTSGVPFSGTRVPFFTSVVQVAPGRLYTGYGYYDSEALKSAGYSIITSVVTTTTCPTSSATPTLPPSPTGSLCSPHGDHWHCEPYPSSTQSSAVGECEPHGDHWHCPPGAPEPTTPPPVETSTSSPPPTGECEPHGDHWHCPPGAPEPATPPPASPSSTVSSTTTPPSTDCEPHGDHWHCPDGVPEPTTSPVFSPTGSLGEGDSGSQCEPHGDHWHCPDGVSEPTTLPPASTPTDTPGGGESGQCEPHGDHWHCPDGVPEPTTPPGASLTGSPGGGSGDSSGECEPHGDHWHCPDGVPEPTTPPGGAAPSRTLVTTTMTTTGPGRASGGPSSSAVATAGVGRVSVAASGWVHVGLVLGGLGAVVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SQL1</accession>
    <name>A0AAN6SQL1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetylgalactosaminide beta-1,3-galactosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.122</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">C8A01DRAFT_47779</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.122" evidence="4"/>
    <dbReference type="EMBL" id="MU854423">
        <property type="protein sequence ID" value="KAK4038645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SQL1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016263">
        <property type="term" value="F:glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026050">
        <property type="entry name" value="C1GALT1/C1GALT1_chp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003378">
        <property type="entry name" value="Fringe-like_glycosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033:SF43">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033">
        <property type="entry name" value="BETA1,3-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02434">
        <property type="entry name" value="Fringe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="Fringe-like glycosyltransferase" evidence="14">
        <location>
            <begin position="202"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="452"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="467"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK4038645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="520" mass="59447" checksum="5E4DD0AADA63516A" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SQP3</accession>
    <name>A0AAN6SQP3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial genome maintenance protein MGM101</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">C8A01DRAFT_36967</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
            <location evidence="1">Mitochondrion nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MGM101 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854411">
        <property type="protein sequence ID" value="KAK4039067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SQP3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000262">
        <property type="term" value="C:mitochondrial chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000725">
        <property type="term" value="P:recombinational repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009446">
        <property type="entry name" value="Mgm101"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31404">
        <property type="entry name" value="MITOCHONDRIAL GENOME MAINTENANCE PROTEIN MGM101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31404:SF0">
        <property type="entry name" value="MITOCHONDRIAL GENOME MAINTENANCE PROTEIN MGM101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06420">
        <property type="entry name" value="Mgm101p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1135">Mitochondrion nucleoid</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="30"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="39"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="69"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK4039067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="321" mass="34561" checksum="61AB69C22BDD9348" modified="2024-10-02" version="1">MRSRALQAIRPMRVASPSILPIQYLRSPARRSPILKQLARAASSSSYTPRPRTTTSSSINPSRARAAPAPRPSTPAAPPTAPATPVLDPQAAIPPSATVADVDPQLAAQIPTPETNSTAAAPSPAFTAALSGGSNGAGPGPAIDWSSSFHGLSTTPFSPETAAVLMQPLNALDIEIKPDGIIYLPEIKYRRILNRAFGPGGWGLAPRGELVVGEKVVTREYALVVHGRFIAQARGECQYFSEETIPTAGEGCKSNALLRCCKDLGIASELWDPRFIREFKKAHCQELWVEHVVNKKRRQIWTRKDGEPAYPYQVAKGTSRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SR79</accession>
    <name>A0AAN6SR79_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_16688</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854403">
        <property type="protein sequence ID" value="KAK4039320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SR79"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4039320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="165" mass="18583" checksum="75DECBD2E8C919DD" modified="2024-10-02" version="1">MLHWDLTEYLWSLENLAENLWPAWTWSSCCFGASALAKACQLYFWPSREHEAASGTVLTALTAYHAGFSLAYLSALYLASRCSRHAQVLQGKVREQLRQRASWGLHPKGAADGTVCEDDVRAWGGFNFALVGWVANQRHLRTIPLKSKHPPWIWVSGLIANWVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SR93</accession>
    <name>A0AAN6SR93_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">1,3-beta-glucanosyltransferase</fullName>
            <ecNumber evidence="9">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">C8A01DRAFT_36905</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cell membrane</location>
            <topology evidence="1 9">Lipid-anchor</topology>
            <topology evidence="1 9">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 72 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="9"/>
    <dbReference type="EMBL" id="MU854409">
        <property type="protein sequence ID" value="KAK4039143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SR93"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042124">
        <property type="term" value="F:1,3-beta-glucanosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071970">
        <property type="term" value="P:fungal-type cell wall (1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000032">
        <property type="entry name" value="1,3-beta-glucanosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004886">
        <property type="entry name" value="Glucanosyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468:SF4">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03198">
        <property type="entry name" value="Glyco_hydro_72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 9" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8 9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042667617" description="1,3-beta-glucanosyltransferase" evidence="9">
        <location>
            <begin position="18"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="461"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="423"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="433"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK4039143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="486" mass="51724" checksum="B00F7580542E8695" modified="2024-10-02" version="1">MLLHSALLALGATLAAAVQPLEVQGEYFINPKTGNRFQIVGVAYQPGGSAGYDKAAGRDPLSDPDICMRDAALLQVMGVNTIRVYNVNPDVNHDKCASIFNAAGMYMVLDVNSPLVGDSLTSDKPWESYYAAYLNRTFAVVEAFKDYPNTLAFFSGNEVLNNEETGAAVPPYVRAVTRDIKNYIKKHVSRTIPVGYSAADVRSILFDTYNYFQCSIEGEDDDISRGDIFALNSYSWCAESSFEAAGYNQLVSGFKGNAVPIFFSEYGCNTPSPRVFTEVGTIYGDKMTGVFSGGVVYEYTQEPNNYGLVQMNKDGSAKLMADFVSLQGQYGKLDFAKIQDQKPASSSTAKAPVCDSKLITTDGFSNNFTLPVLPPGAQEIIDNGVKPAPKGQLIKITDWKVKYTVKNPDGSAITNLAVKPLADDEINSPGSNTDSGTETSNDGSTGSETSSSPASTTSHNAAAGAGAGVLPAMAIGAFAVVAGIAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SRJ2</accession>
    <name>A0AAN6SRJ2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Arabinoxylan hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_47064</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854399">
        <property type="protein sequence ID" value="KAK4039501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SRJ2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09001">
        <property type="entry name" value="GH43_FsAxh1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041542">
        <property type="entry name" value="GH43_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051795">
        <property type="entry name" value="Glycosyl_Hydrlase_43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812">
        <property type="entry name" value="BETA-XYLOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812:SF15">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G00930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17851">
        <property type="entry name" value="GH43_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042990274" evidence="5">
        <location>
            <begin position="23"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-xylosidase C-terminal Concanavalin A-like" evidence="6">
        <location>
            <begin position="341"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4039501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="549" mass="60579" checksum="9160B300104113CA" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SRM4</accession>
    <name>A0AAN6SRM4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_35914</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854385">
        <property type="protein sequence ID" value="KAK4040042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SRM4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042957172" evidence="2">
        <location>
            <begin position="23"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="337"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="376"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4040042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="473" mass="43198" checksum="342F69BFCD3AD09C" modified="2024-10-02" version="1">MHLSARTFVAVLLAAAARDVAATPQRDNNGDAGPGNGGGNGGGNRGGNGGGNNIRIQTVATAAPAATGIPPEVLAAQQSSAAAAASAAAAANNAAAASGLRQPPGLQADESPASLLPLPGLANGDAVAPPAVVDASAVVTLAPTEVASQPAVVVTQSPAGGLRQPPGLNQDAGASLVPLPTPPAVDTSVAGSATSSAAQVIGSFTQIVGGTTSAAAAETSAAAAVSEAATSAVAETSTGAGAVIGSFTPIAGGTTAAAVAASSSTAAAAVIGSFSPIVAASPSAAGPSSFVTPAQGFVFTNSTAAGEGAAAAQPTGGLVPLPSGGVGTGAGNGSLQPLPGLTNGTTGGSPSLRPLPGSPDAEATGGSLQPLPNNPAATGTAVPTSAGGAAAASSRLTTLTTVTNGVTSTLVTAVAAEQTGVISGGNGTENAGAAAGGAAGGAGTATAGVGGSKGVRSVWLAVVVGGLVGVLMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SRT7</accession>
    <name>A0AAN6SRT7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_36083</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854388">
        <property type="protein sequence ID" value="KAK4039950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SRT7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="569"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="271"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4039950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="598" mass="64471" checksum="F3139413D6DF35DB" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6STV7</accession>
    <name>A0AAN6STV7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Serine--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="2">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Seryl-tRNA synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Seryl-tRNA(Ser) synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">C8A01DRAFT_44120</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the attachment of serine to tRNA(Ser) in a two-step reaction: serine is first activated by ATP to form Ser-AMP and then transferred to the acceptor end of tRNA(Ser).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.11" evidence="2"/>
    <dbReference type="EMBL" id="MU854334">
        <property type="protein sequence ID" value="KAK4042904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6STV7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00770">
        <property type="entry name" value="SerRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.40:FF:000003">
        <property type="entry name" value="Serine--tRNA ligase cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000026">
        <property type="entry name" value="Seryl-tRNA synthetase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.40">
        <property type="entry name" value="Serine-tRNA synthetase, tRNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015866">
        <property type="entry name" value="Ser-tRNA-synth_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042103">
        <property type="entry name" value="SerRS_1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033729">
        <property type="entry name" value="SerRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00414">
        <property type="entry name" value="serS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11778">
        <property type="entry name" value="SERYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02403">
        <property type="entry name" value="Seryl_tRNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001529">
        <property type="entry name" value="Ser-tRNA-synth_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00981">
        <property type="entry name" value="TRNASYNTHSER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="tRNA-binding arm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="15">
        <location>
            <begin position="145"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="66"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="269"/>
            <end position="271"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="285"/>
            <end position="288"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="353"/>
            <end position="356"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="389"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for serine binding" evidence="12">
        <location>
            <position position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00058708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00074532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001529-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001529-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK4042904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="449" mass="51423" checksum="5735427454950DFA" modified="2024-10-02" version="1">MLDVNDFIVERGGNPDKIRESQRKRFAPVEAVDEVIAMWEDHRKTAYSATQLNAKINEVQKQIGPKKKAKEDVTDLLKQKADIEKEKKELLASAAEKEKALKIKVKAIGNLVHESVPVSNNEDNNTVERTWAPEGVTFEKRNVLSHHEVLDKLDGYDPERGVKVVGHRGYFLRRWGVFLNQAIINYGLEFLHDREYVPLQTPQLMLRDQMAKTAQLSQFDEELYKVTGDQADKYLIATSEQPISAYHSDEWLQPKQLPLKYAGYSTCFRKEAGAHGKDVWGIFRVHEFTKVEQFCVTDPEKSWEMFENMISTSEDFYKSLGIPHRVVAIVSGALTAKKLDLEAWFPHQGEFKELVSCSNCTDYQSRDLEIRFGIKKQTDVKKTYVHCLNSTLTATTRTICAILENFQTEDGVNIPEPLRKYLPGAPEFIPFAKKAAEKKEAEKKEIPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SU38</accession>
    <name>A0AAN6SU38_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_33538</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854342">
        <property type="protein sequence ID" value="KAK4042335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SU38"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000104">
        <property type="entry name" value="ATP-binding cassette sub-family F member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000882">
        <property type="entry name" value="Translation initiation regulator (Gcn20)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF117">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="197"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="529"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="132"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="280"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4042335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="749" mass="82423" checksum="2566C6FF7AB8D49A" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SUD9</accession>
    <name>A0AAN6SUD9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">uracil phosphoribosyltransferase</fullName>
            <ecNumber evidence="4">2.4.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">C8A01DRAFT_13482</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uracil: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UPRTase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.9" evidence="4"/>
    <dbReference type="EMBL" id="MU854334">
        <property type="protein sequence ID" value="KAK4042907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SUD9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004845">
        <property type="term" value="F:uracil phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008655">
        <property type="term" value="P:pyrimidine-containing compound salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000023">
        <property type="entry name" value="Probable uracil phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001097">
        <property type="entry name" value="PRK00129.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14681">
        <property type="entry name" value="UPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="6 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="10">
        <location>
            <begin position="41"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK4042907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="244" mass="27157" checksum="7214643E92CB2FC3" modified="2024-10-02" version="1">MSDDVKPAPTQCVGPLYRSESQKPTAVVSTGVEFETVTILPQTPQLIALLSIIRNKDTQRGDFIFYSNRIIRLLVEEGLNHLPTVEHTVTTPVGRPYDGLSFQGKICGVSIMRAGEAMEQGLRECCRSVRIGKILIQRDEESSQPKLFYDKLPEDIADRWVLLLDPMLATGGSAIMAVDVLKSRGVPEERILFLNVLASPKGIQNFATKFPKLRLVTAFVDQGLDEKNYIIPGLGDFGDRYYTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SUJ0</accession>
    <name>A0AAN6SUJ0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_32879</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854332">
        <property type="protein sequence ID" value="KAK4043087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SUJ0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4043087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="77" mass="8852" checksum="1DA78C7E907FC16D" modified="2024-10-02" version="1">MAATTFFVTSSPVNYGRSGYNKGNSDDDDEETKFRNYGRSGYNKGNSDDNDEETKFRNYGRSGYNKDDKDDEEDKQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SUS2</accession>
    <name>A0AAN6SUS2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cell division control protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_32955</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the CDC6/cdc18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854333">
        <property type="protein sequence ID" value="KAK4043010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SUS2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000547">
        <property type="entry name" value="Cell division control protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016314">
        <property type="entry name" value="Cdc6/18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054425">
        <property type="entry name" value="Cdc6_ORC1-like_ATPase_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050311">
        <property type="entry name" value="ORC1/CDC6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763:SF26">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22606">
        <property type="entry name" value="Cdc6-ORC-like_ATPase_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001767">
        <property type="entry name" value="Cdc6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="7">
        <location>
            <begin position="174"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="35"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="67"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR001767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4043010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="629" mass="69032" checksum="6D310E861AB221CF" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2025-10-08" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SVU3</accession>
    <name>A0AAN6SVU3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_31721</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854321">
        <property type="protein sequence ID" value="KAK4044120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050668">
        <property type="entry name" value="Cytochrome_b5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359">
        <property type="entry name" value="CYTOCHROME B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="5">
        <location>
            <begin position="971"/>
            <end position="1049"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4044120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1281" mass="145050" checksum="868ECC1D2B9A7390" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SVV2</accession>
    <name>A0AAN6SVV2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Fungal-specific transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_12540</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854322">
        <property type="protein sequence ID" value="KAK4043973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SVV2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051711">
        <property type="entry name" value="Stress_Response_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540:SF1">
        <property type="entry name" value="ACTIVATOR OF STRESS GENES 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540">
        <property type="entry name" value="THIAMINE REPRESSIBLE GENES REGULATORY PROTEIN THI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="720"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="891"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="972"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="8"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="767"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
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            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="983"/>
            <end position="1025"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4043973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1053" mass="117811" checksum="29C46FA819200267" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P3U5</accession>
    <name>A0AAN6P3U5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_21507</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854934">
        <property type="protein sequence ID" value="KAK4031249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4031249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="161" mass="17844" checksum="4119DF393A9F4BFA" modified="2024-10-02" version="1">MGSTTLIRGFKVSVATFDAFLAANNVYETYGTPPFYGRHPDKDPISKLLFAKISQYDSDADKNKFRVLIPAIEGAGRSKTAYVAYAWAAVRAHREIKMDEDLPAGVPKGFEELRQEILGYGKDVGDGDKIADEGKLGIYMVVTYDIRGDYGDELDRSEGLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="2">Ankyrin repeat-containing domain protein</fullName>
        </submittedName>
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        <name type="scientific">Parachaetomium inaequale</name>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854851">
        <property type="protein sequence ID" value="KAK4031351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P423"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051616">
        <property type="entry name" value="Cul2-RING_E3_ligase_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46224">
        <property type="entry name" value="ANKYRIN REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46224:SF64">
        <property type="entry name" value="IQ MOTIF AND ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="47"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="253"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="286"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="319"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="352"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4031351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="374" mass="40563" checksum="42B3C37EBBD41D04" modified="2024-10-02" version="1">MQVGRREKYYTPLHFAAAGGYLQDLELMLASVPSEEAASIPLALNSKDRTPLWFAAANGHIDAVKLLLRLGAKAHINHLTRQPQYPTTLWAMVNAKPPNSLEGITALLISGADPNIQQPTTGQTLLHHAALTNNTPLLTLLQHNANPHLPGNTSALPLHHPAYYGYLPCVTALLQPFPHHPPLDINTPNNAGSTLLLLAARFGYDFLLPLLLAHKADPHHRDISGLTFLFGHEAVVQLLLDKGAAVDAKEDSTGRKPLSYAARYGREAVVQLLLDKGADVDAKDDSSETPLSWVATTGHETIVRQLLDKDADVDAKDDSGWTPLFYAAARGHEAVVRQLLDNDADVEAKDGSGRTPLFYAAVRGHEAVVRLLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P463</accession>
    <name>A0AAN6P463_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_42257</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854915">
        <property type="protein sequence ID" value="KAK4031270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P463"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4031270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="280" mass="29600" checksum="3700F8350971348B" modified="2024-10-02" version="1">MATVSLDNQIFYDPAMATGPKPASRGLSVRKAGPSPSPPPQDAHNLQHGGAERSQVDVILISDDELDNGLDLDGQSDTSFESLDWLRPAPTGNGVDAASDDSNEPEHPKLSAYFRRCRGGESSQAKVDNEDSEGDEPEPADAGTPLQPPSSQGLIDFWRDVGGQRSPAVPPPVVESRARTPTPLDDESTGELEPADTEPPLQPQSPSGAAPGHGADLRQRSGNCRLSQHRDHSDDNDQASDLEHCAPDDRGESVASSPTLLDDESTGEPEPADAELSLPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P5S8</accession>
    <name>A0AAN6P5S8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_50888</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854627">
        <property type="protein sequence ID" value="KAK4032281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P5S8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF12">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4032281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="449" mass="51530" checksum="5E67493F65A48BEF" modified="2024-10-02" version="1">MAPHPPALEYALRCSNWNTRGWTFQERHLSRRCIYFSSDFVYFQCGESTRCETGGDLLPWLDITPTTGYSSRAEALRKVEMNPLLYLPTCASPDPLSFQENPNPVDHYVYKRHRFDVYQEIVEAYSRRQLSFVADALNAFAGVGRVLERAFDCSILSGLPTCYLDHALIWAHEGSWTRRVLPDSSHNNRDGLSTKVFPSWSWAGWTGSMQYLLLTKGENTYRRENHEYARSEIECFQIFHSGELHEIFKDKARMNAVLTRNLGSYSQKPILKTYPIYLGYEERKTQGIQGPDFGPDALQFWTEAVRDDAFTLTQLGHGHLIADREHGNVVGEQGVIKMLDGAKTHCGLMLSFHSKDTRTWHKPTRGRLEWILVSSFGDAHDRRSGLKTVDTEVRLFDERKLPYKGPGSGLVNVMLIEWDDEVAERLTVAQVHRQAWEAAGPERKHIRLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P615</accession>
    <name>A0AAN6P615_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_21321</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854805">
        <property type="protein sequence ID" value="KAK4031447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P615"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4031447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="52" mass="5747" checksum="B6D0F1A1F47EA569" modified="2024-10-02" version="1" fragment="single">KQGKDDFIEELQSIVERVSIRFGNDLLNSSRPLVSSKGSSTIHFAKLPRCAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P628</accession>
    <name>A0AAN6P628_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_50759</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854609">
        <property type="protein sequence ID" value="KAK4032448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P628"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="104"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4032448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="266" mass="28477" checksum="F39A7196B059232A" modified="2024-10-02" version="1">MPPTARTPREAAPAPAPAPAAIAADLPSLSKKTPSPSPALNLPRQQPPTETATIPSYYGSLTSGPDPGAVAGITLGSVAAFILLLWLVYTCINLGNPNSGSNDTSTVVTEGTGSVYTRRNRGQRSRSRRASRRGTGHKETVEIRRGSIHARGGPVIVEAVGPGVSTSDVDRVIIEERRRSVSRHRASMPPPPPRRVAVSSSGSGEDDDDEDEVVVIEEHSLPPSRRHRSRVRSVERRSSGFREVDPERFAGGDASFVEVRRSGSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P6T2</accession>
    <name>A0AAN6P6T2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heterokaryon incompatibility protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_20262</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854583">
        <property type="protein sequence ID" value="KAK4032695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P6T2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF10">
        <property type="entry name" value="TOL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="247"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4032695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="525" mass="58088" checksum="94E344BD993F434A" modified="2024-10-02" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P6W6</accession>
    <name>A0AAN6P6W6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_40758</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854575">
        <property type="protein sequence ID" value="KAK4032784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P6W6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="36"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="288"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="303"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4032784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="422" mass="45016" checksum="59F1F9D88FF27EB7" modified="2024-10-02" version="1">MAGPSPNPALDGESRVGEIIAILTVASILSTLAVALRCYSRAVILRSFGLDDAVIVPAQILTLGSAVAIGLESKYGLGRHIWVMPDEDYIPYMKSFYSSIVVYNVAVCMTKISILLQYKRIFNNTVLRKIILVGLVFLTCWGITLCFLLPMVCMPVAAFWDPNVKGFCLNNGTIWYVMAGVNVVTDFAVISMPIPLISSLQLPAKQKAMLLIVFTLGVFPCAVSIYRIKTLSAAAKSTDSTWDNIEAATFSFLELSVGVIAVCLPTLRPILVHSMPRLFGSLLRSATGGTGPTGGRVSRTPFGGAGSGAGTGRGGVGSSGLYHGSTLRESDSTEGLRLDDEEAVLPRSRMENDIEFVELDKSGGVHGLGKRYSVSVVAGWEPGSISQLGGGGLDKNGIQTTTVVTQKVTFASMMEEDRRKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P787</accession>
    <name>A0AAN6P787_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_19964</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854556">
        <property type="protein sequence ID" value="KAK4033046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P787"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050466">
        <property type="entry name" value="Carboxylest/Gibb_receptor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23024:SF339">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23024">
        <property type="entry name" value="ARYLACETAMIDE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="1">
        <location>
            <begin position="55"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4033046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="324" mass="35205" checksum="8F7B202A3528639C" modified="2024-10-02" version="1">MDYLEKGKIVEAELQARFDRVNVTYKTVNNTPIETAIFIPKTFSSRTEPATAPVLVHFHGGGLVTGSNPDFLFLVDWVRELAHSTNAIFISPAYRLAPETPAVDILDDIADFWTWLHADLPATIRSLHPHLTPDLSRLAAVGESAGGYLALQSAFLFNRTAKLRAIIAQYPALHTDLAAFNPRPAKPDPALDAVVAEYVKGVVPGTVRTSTAWPGLAETNIAALTNGLMRRLFGADAEGRLTLGYALRKAEEVLPPVWVVQGDEDELVAKGAADELVERVRAERPGAVVKYTVRPGGHGFDGENTLADGWVAEGVEFVKGYWLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P7Z3</accession>
    <name>A0AAN6P7Z3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="8">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_41117</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="8"/>
    <dbReference type="EMBL" id="MU854610">
        <property type="protein sequence ID" value="KAK4032435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P7Z3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000213">
        <property type="entry name" value="Carboxylic ester hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042664398" description="Carboxylic ester hydrolase" evidence="8">
        <location>
            <begin position="19"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="9">
        <location>
            <begin position="33"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4032435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="576" mass="61554" checksum="3EFCF7D9B4F6F7A9" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P847</accession>
    <name>A0AAN6P847_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_40125</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854531">
        <property type="protein sequence ID" value="KAK4033430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P847"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031942">
        <property type="term" value="C:i-AAA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051787">
        <property type="term" value="F:misfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24145">
        <property type="entry name" value="Mgr3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040201">
        <property type="entry name" value="Mrg3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28142">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE I-AAA PROTEASE SUPERCOMPLEX SUBUNIT MGR3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28142:SF1">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE I-AAA PROTEASE SUPERCOMPLEX SUBUNIT MGR3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13176">
        <property type="entry name" value="TPR_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="448"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4033430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="500" mass="55615" checksum="C9A1FCC5C1A75BE1" modified="2024-10-02" version="1">MPIPRAAILRPAGALRLSQRCTSPLVLRSQPSRCRQKTPLALVILPANGQCRLKSTAPPKEDPEGSAKQAGQTPKPGPYFMRMIWQAIKSDTSRTWYVIRNTSFSQVMRQSPGEAFGAIVAVTGAVAILIYCVYAYYTYFNSRQFTRYPEPVARALRKALYFSNHDPDPQRALKYYKQALELCDQEGLDHFSDDVMGIKIQVAAWLEKIESYQNAIGVLENLLGDCKRWVEVMEKSAAEGTLPKLEPPAPPKEGEPAVPEVPQESFWAKRTRILAKAVSISVKLANLYSDEHVLEREPAHERLVWAVETTLREVQRRAKDGLKEGEGAWMSPDEIGGSLEALAHSYQDKSQYHLAVPLFFQALRLCQDPCHIALLMNNIATSFAEHPLIPPGDAPVHAMMAESKTWVSAAEQRASYLAAAQRWAQNAIDHAAEPQGEKRTPECDQACAVALSNLGSVLAMLGKNREAREKYEQAIALSQKFGFEDYAAEADARLQRLPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P882</accession>
    <name>A0AAN6P882_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_20316</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854590">
        <property type="protein sequence ID" value="KAK4032617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P882"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4032617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="113" mass="12522" checksum="BF2FEB90CB78F1D8" modified="2024-10-02" version="1">MSRVHFRVFMSQAKAPLVDPHSFFFPFDSETMECVKDIPVFKQGRAVPIVDLPVSPGVFKAGNSDGANYDSERVLVKFQALFNLQSTLAFLDGGRVTGKECGDGRSNAKEQRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P8B3</accession>
    <name>A0AAN6P8B3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RTA1 like protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_39939</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854520">
        <property type="protein sequence ID" value="KAK4033604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P8B3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF35">
        <property type="entry name" value="RTA1 DOMAIN PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="300"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4033604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="343" mass="37213" checksum="1D2D464B9D2C0154" modified="2024-10-02" version="1">MAEDQAYEGGFKLYRYDPSLAGNIVFVVLFALATIGHVVFLVRKRTWYFIPFVIACLFETVGYIGRAIAAQEAPDFSLNVYIIQTLLILLGPALLAASIYMILGRLIRMLGAEEYALIRTNWMTKVFVTGDVLSFLAQGAGGGLLAQAKTHDDQKRGEAIILGGLGIQVAFFGFFIVTTVVFHRRMAAQPTARSYSVTGPWRALITALYASSALVMVRSVFRMVEFGMGNDSILMSSEGYLLGLDGALMFIVVVIFLWSHPSRALAGYKESLASSTESGRNTAESFQMLAVHPEGAPPLGTLAPGKYDSDSTAVGGQQGYAYDAPPARRGHGGDHRYSSSYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P8Q0</accession>
    <name>A0AAN6P8Q0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_49682</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854509">
        <property type="protein sequence ID" value="KAK4033799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P8Q0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38850">
        <property type="entry name" value="CERATO-PLATANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38850:SF2">
        <property type="entry name" value="CERATO-PLATANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043021619" evidence="1">
        <location>
            <begin position="19"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4033799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="194" mass="20830" checksum="485E7384F033EAD4" modified="2024-10-02" version="1">MFTLFALLFTLLAALVAGESHGITPHDMYSSSVGVLGCKINTNRVAYWPMSLLRIDQSGGTYDISYDAYNYLVSGQSATEHQITGGAVTMEVTNIPADNCVQHLKAGGLPLSASNSMNYVASCLGQPSSWVARNYRLFNIQDPVCHWGYDEQCTVDLAVSNQPSCPHALGATNGRLPDTVFNIEYGTGMVVAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P8T7</accession>
    <name>A0AAN6P8T7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_50752</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the folylpolyglutamate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854607">
        <property type="protein sequence ID" value="KAK4032468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P8T7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001645">
        <property type="entry name" value="Folylpolyglutamate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136:SF5">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="MurD-like peptide ligases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4032468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="275" mass="31393" checksum="34D332F2F53B0889" modified="2024-10-02" version="1">MPGYLQLLALTSVYTFKKEAINIAIYEVHTGRRKDVTNIFERPVYKSGIMKYRQPAYSVIQKEYIAKEVLEAEATEFDCPLDFVDIYIHLPEYPRLHLPAQKQNVSLAIRLANAYLGIYNDELSPDDIILGTSRDSHDWALDIFDSEVRLSHTFRELRRVLIFGHESVHNTRDLIATIIRSYEEHNSRFDLVILSPYKRYGISIHQSSSDSCNTLLGPLQPLISIANLTSVIKMAIEKWDQEVVYTLVTGSTYLVGEALGYLQTGLDGTSHDYSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P8X3</accession>
    <name>A0AAN6P8X3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1748-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_40624</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854564">
        <property type="protein sequence ID" value="KAK4032915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P8X3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013726">
        <property type="entry name" value="Mitofissin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28075">
        <property type="entry name" value="CHROMOSOME 16, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28075:SF1">
        <property type="entry name" value="DUF1748-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08520">
        <property type="entry name" value="Mitofissin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4032915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="87" mass="9717" checksum="73F325332A627F2A" modified="2024-10-02" version="1">MVLLDLLTLGLWSKLGRLTHYAFDAVLFSAFLAGMKRSTGLTFKTEKVAGDNKEVTKWVDKYLGVGEWVMDQSVAIAGSSGWFERTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PAV8</accession>
    <name>A0AAN6PAV8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_48769</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854460">
        <property type="protein sequence ID" value="KAK4034938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PAV8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="428"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="447"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="475"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4034938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="525" mass="58043" checksum="6C79A8A4179F1E48" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PAY5</accession>
    <name>A0AAN6PAY5_9PEZI</name>
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        <recommendedName>
            <fullName evidence="4">Threonine/serine exporter-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_18293</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ThrE exporter (TC 2.A.79) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAK4034983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PAY5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="ThrE-like_N"/>
    </dbReference>
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        <property type="entry name" value="ThrE/Ser_Exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31082">
        <property type="entry name" value="PHEROMONE-REGULATED MEMBRANE PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31082:SF4">
        <property type="entry name" value="PHEROMONE-REGULATED MEMBRANE PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ThrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="506"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
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            <end position="549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
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            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="583"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="622"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
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            <end position="689"/>
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            <end position="737"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
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            <end position="833"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
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            <end position="909"/>
        </location>
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            <end position="642"/>
        </location>
    </feature>
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        <location>
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            <end position="251"/>
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        <location>
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            <end position="334"/>
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        <location>
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    </feature>
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            <end position="62"/>
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        <location>
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            <end position="98"/>
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        </location>
    </feature>
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            <end position="322"/>
        </location>
    </feature>
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            <end position="795"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4034983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="921" mass="99973" checksum="96D50310BAFFF8AF" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PBL8</accession>
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        <submittedName>
            <fullName evidence="10">Fungal-specific transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="10" type="ORF">C8A01DRAFT_48403</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
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            <taxon>Sordariomycetidae</taxon>
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            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAK4035358.1"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF12">
        <property type="entry name" value="RFEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="237"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="190"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="375"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="466"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="17"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="208"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="466"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4035358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1016" mass="110048" checksum="BA2B47FBF11007C2" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PCD4</accession>
    <name>A0AAN6PCD4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_38737</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854465">
        <property type="protein sequence ID" value="KAK4034807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PCD4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050729">
        <property type="entry name" value="Rho-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176:SF125">
        <property type="entry name" value="GTPASE ACTIVATOR (BEM2), PUTATIVE (AFU_ORTHOLOGUE AFUA_7G04450)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176">
        <property type="entry name" value="RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="3">
        <location>
            <begin position="390"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="583"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="128"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="157"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="186"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="231"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="295"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="591"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="611"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="637"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="655"/>
            <end position="666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4034807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="681" mass="76104" checksum="B77F9B1C21162B6B" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PCH6</accession>
    <name>A0AAN6PCH6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methionine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_17555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854432">
        <property type="protein sequence ID" value="KAK4038343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PCH6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003871">
        <property type="term" value="F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="CIMS_C_terminal_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002629">
        <property type="entry name" value="Met_Synth_C/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005085">
        <property type="entry name" value="PRK06520.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43844">
        <property type="entry name" value="METHIONINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43844:SF1">
        <property type="entry name" value="METHIONINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01717">
        <property type="entry name" value="Meth_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="UROD/MetE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cobalamin-independent methionine synthase MetE C-terminal/archaeal" evidence="1">
        <location>
            <begin position="13"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4038343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="384" mass="42606" checksum="18A7D1C8E5A58C17" modified="2024-10-02" version="1">MPLPAGVYRADHVGSFLRPAPILRARETLDTATPIAAADLRALENEHITGVVQKQIASGLQAVTDGEFRRAWFHIDFLQHLAGVERHGSLSSTNVTSHGVTPPKLVVVGKLGHPEGIQVEDYKFVEGVREQDAAALAKKVTTKVCIPSPTMVHFRGGREAISTEAYPTLEPFFEDLVKAYQAEIADLYAAGCRFVQLDDTNLAYLCDEGMRSEAAKRHGEDPQKLTKQYAALINAAVSQRPKDMVIGIHLCRGNFRSQWFAEGGYEPVAEVLFRELDVDVYFLEYDDARSGDFSPLRFLPENKTVVLGVMSSKKAELDDKEDIVKRLNEAAKFCPRGLDQLCLSHQCGFSSTMEGNDLTEEQQWAKVKLEVEIAKQVWGEDLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PCP0</accession>
    <name>A0AAN6PCP0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heterokaryon incompatibility protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_19495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854521">
        <property type="protein sequence ID" value="KAK4033587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PCP0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF16">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="90"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4033587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="311" mass="34694" checksum="11A39C9F033AA8CC" modified="2024-10-02" version="1">MDEDDITLRVFVPPGVESPHPSIRTGTPVSYYSGSAECLELARRWLGECAQNHKDCKVPSDTLMPTRVIDIGGDGRDPVLVETEGRPGQYATLSYCWGKKPQLRTTKETLSAFLEAIPVGELQKTALDALEICRHLGIPYLWIDALCIVQDDEDDWLRESARMCDIYSSSALTIAAARSLSARQGVFGYQQYGSREYSQISLFRGTEVYARKVPVGEHVGKPLAVNIASQETGRVAEASWILRPQELPLARRAWTVPGPGIYTCRELSRFGACTLDGHDSHMSAGFMWLCFRHRIHLLYLPAHTSLNLDRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PCX9</accession>
    <name>A0AAN6PCX9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="9">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_18183</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Esterase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the carbohydrate esterase 1 (CE1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="9"/>
    <dbReference type="EMBL" id="MU854455">
        <property type="protein sequence ID" value="KAK4035107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PCX9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010126">
        <property type="entry name" value="Esterase_phb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050955">
        <property type="entry name" value="Plant_Biomass_Hydrol_Est"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01840">
        <property type="entry name" value="esterase_phb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43037:SF3">
        <property type="entry name" value="FERULOYL ESTERASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43037">
        <property type="entry name" value="UNNAMED PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10503">
        <property type="entry name" value="Esterase_PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 9 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0964">Secreted</keyword>
    <keyword evidence="2 9" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4035107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="292" mass="31447" checksum="E0406FD45324DAD6" modified="2024-10-02" version="1">MALSSVQSAAVGEQDRQLIKRASLTQVQNFGNNPSGIKMFIYVPAKLQAKPPVVLVLHACAWTAGAFFGTTKYGQLADQHGYVLIYGQTPTDGACWDVSSKQTLTHDGGGDSTGLANMVRYALNKYNGDASRVFVTGESSGAMMTQVMAAVYPDLFAAASEFSGEPAGCFYTGTVRGWNGQCAGGQVHHTAAEWASQVHAMYPGYTGQYPKMQVFHGDVDTTLNINSFNESVKEWSGVFGYSGTPVKTLDNNPGQRLTKYVYGDRLQGIWGHGFGHVVPTNETEALSWFGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PCZ4</accession>
    <name>A0AAN6PCZ4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_18729</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the secreted LysM effector family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854478">
        <property type="protein sequence ID" value="KAK4034493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PCZ4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052210">
        <property type="entry name" value="LysM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997">
        <property type="entry name" value="AM15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997:SF1">
        <property type="entry name" value="PEPTIDOGLYCAN-BINDING LYSIN DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="LysM" evidence="5">
        <location>
            <begin position="10"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="5">
        <location>
            <begin position="96"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="62"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="64"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4034493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="147" mass="15267" checksum="7DD3463951006D9B" modified="2024-10-02" version="1">MTGSPADCNKWSLVTDGLSCTDLATQAGISLAQFLAWNPAVSSDCSTNYWLGEAYCVGVAGGSTPTTKPTTTAKPTSTKPTPPRPTMSGSPANCNKWSLVTNGLTYTALASQAGITLKQFLAWNPAVSSDCVTNYWLGEAYCVGVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PD39</accession>
    <name>A0AAN6PD39_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_17233</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854421">
        <property type="protein sequence ID" value="KAK4038696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PD39"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2790">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="351"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4038696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="403" mass="43017" checksum="F9F8AA40745ABDE7" modified="2024-10-02" version="1">MAWDSKAARRRQSSAASGTRNIAIHARQQAKRAAQPQSQHVADPFLQDFLNPSFDAASYLNATLPPLQTSSQASRSQGSSQGAVPLAELSIQTQTVLSQLNAHTTRLTNTLTELTNDILRSGGRLAYEVELLRGETLGLSETLSEGLEDDIAKFVPGGIREIVTEPRAAADGHGGASSHQRRMSILAATPAATTTTAETPAAAPTSQAETPTAPNEPPYIAQLRTLTLVRSRLDSVIKTFGDAMEFVFPPSEVSVSSSFLSVSAPDAGGGGNHSTEEKGQQVLQTLRDEISRLLNNAQDPIKGIEDAARRIEELKELATVWKGTAEEKGRARFIESLAKMVEDRHRELLREAEQQSGRRGGGAKSQMEAGAGKVAEADAGQAEAKGYGAYGLISQLQKLRNGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PDB1</accession>
    <name>A0AAN6PDB1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Elongation factor 1-beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_47606</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the EF-1-beta/EF-1-delta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854418">
        <property type="protein sequence ID" value="KAK4038801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PDB1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005853">
        <property type="term" value="C:eukaryotic translation elongation factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00292">
        <property type="entry name" value="EF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10308">
        <property type="entry name" value="GST_C_eEF1b_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.60:FF:000001">
        <property type="entry name" value="Elongation factor 1-beta 1 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.130:FF:000001">
        <property type="entry name" value="Putative Elongation factor 1-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036219">
        <property type="entry name" value="eEF-1beta-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018940">
        <property type="entry name" value="EF-1_beta_acid_region_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049720">
        <property type="entry name" value="EF1B_bsu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014038">
        <property type="entry name" value="EF1B_bsu/dsu_GNE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribsomal_bS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001326">
        <property type="entry name" value="Transl_elong_EF1B_B/D_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11595">
        <property type="entry name" value="EF-HAND AND COILED-COIL DOMAIN-CONTAINING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11595:SF21">
        <property type="entry name" value="ELONGATION FACTOR 1-BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10587">
        <property type="entry name" value="EF-1_beta_acid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00736">
        <property type="entry name" value="EF1_GNE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01182">
        <property type="entry name" value="EF-1_beta_acid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00888">
        <property type="entry name" value="EF1_GNE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54984">
        <property type="entry name" value="eEF-1beta-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00824">
        <property type="entry name" value="EF1BD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00825">
        <property type="entry name" value="EF1BD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Elongation factor 1 beta central acidic region eukaryote" evidence="8">
        <location>
            <begin position="109"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Translation elongation factor EF1B beta/delta subunit guanine nucleotide exchange" evidence="7">
        <location>
            <begin position="145"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4038801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="231" mass="25323" checksum="500AC9C0D0DD878E" modified="2024-10-02" version="1">MGFTDLLTDAGLAVLNNWLLTRSYVAGYSASQADAVVFKALSAAPDAAKYPNAARWYKHIASYEDEFPTLPGDASKPYTVYGPEVAEVTLNPAKAPAAAEEEEDEDVDLFGSDDEEEDAEAVRIREERLAEYRKKKEGKVKPAAKSVVTMDVKPWDDETDLVALEAAVRGIEKDGLVWGASKLVPVGFGIKKLQINLVVEDDKISTDELGEEICEFEDYVQSVDVVAMQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PE02</accession>
    <name>A0AAN6PE02_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_37892</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854437">
        <property type="protein sequence ID" value="KAK4038190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PE02"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14810">
        <property type="entry name" value="bZIP_u1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37616:SF2">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37616">
        <property type="entry name" value="BZIP TRANSCRIPTION FACTOR 60-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="292"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="160"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="184"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4038190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="430" mass="47853" checksum="113342B51C64A5EB" modified="2024-10-02" version="1">MAGSQQGGGFDPLEFMDFSQYDNNSNNNLYQTGSSSISLKSEGSDATSSLFPTNQGFTAPSHQYNLYKQQTGLVPGALTTTLSMNEPHGYFQEYLDLEQHDMLSGLGEAEDVAFDFSAPLTSGMETSGLDLGFQTPSPDAGLYLNSTINPSAIGGQEPDALTSPLPSTPALSSTPGRVWPGMHQQQAALRAQQQQKQKQQLLQRQQQQLQRQRVQQAKQAQKARSPQTSSSIADQNVQHILNSMRAEPVQYTPIKSVPQVNFTKKQKCEAEMDEDEKFLASEEGKKLSSQERRQLRNKVSARAFRGRRKEYIGWLEGQLTDRINDAGLLRAQNHALIEENARLSSLTKMLLSSDQFRDMLSDLSSDPQKLAGFRAAGEPQAQQQARQQAQQEAQMQARLQADKDANPHVAEQQHLQYQEHFRLHMMSGHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PE85</accession>
    <name>A0AAN6PE85_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NUDIX hydrolase domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_36648</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854402">
        <property type="protein sequence ID" value="KAK4039354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PE85"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047631">
        <property type="term" value="F:ADP-ribose diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006753">
        <property type="term" value="P:nucleoside phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019693">
        <property type="term" value="P:ribose phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18888">
        <property type="entry name" value="NUDIX_ADPRase_Nudt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839:SF1">
        <property type="entry name" value="ADP-SUGAR PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839">
        <property type="entry name" value="UDP/ADP-SUGAR PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="51"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4039354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="186" mass="20681" checksum="71E5F2E4759F13D3" modified="2024-10-02" version="1">MSAGEAKVISTEPLLASEAVWTKLVKKTYRDPNGVTRTWESAERSTRPKGSDIDGVGIVAILEKETGPEIVLQKQYRPPLDKIVIELPAGLIDEGETAEQAAVRELKEETGYVAEVLDTSPVMFQRLPENQDLKPDLEENEFIEVFLVKLADLWEACIRLEAEGYAIDARIANLAEGIEIAKKFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PEA8</accession>
    <name>A0AAN6PEA8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 8">Arabinogalactan endo-beta-1,4-galactanase</fullName>
            <ecNumber evidence="3 8">3.2.1.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_18135</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>The enzyme specifically hydrolyzes (1-&gt;4)-beta-D-galactosidic linkages in type I arabinogalactans.</text>
            <dbReference type="EC" id="3.2.1.89"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyl hydrolase 53 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.89" evidence="3 8"/>
    <dbReference type="EMBL" id="MU854453">
        <property type="protein sequence ID" value="KAK4035153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PEA8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031218">
        <property type="term" value="F:arabinogalactan endo-1,4-beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015926">
        <property type="term" value="F:glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030247">
        <property type="term" value="F:polysaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016998">
        <property type="term" value="P:cell wall macromolecule catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000077">
        <property type="entry name" value="Arabinogalactan endo-beta-1,4-galactanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011683">
        <property type="entry name" value="Glyco_hydro_53"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34983">
        <property type="entry name" value="ARABINOGALACTAN ENDO-BETA-1,4-GALACTANASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34983:SF1">
        <property type="entry name" value="ARABINOGALACTAN ENDO-BETA-1,4-GALACTANASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07745">
        <property type="entry name" value="Glyco_hydro_53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042665314" description="Arabinogalactan endo-beta-1,4-galactanase" evidence="8">
        <location>
            <begin position="19"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00068680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4035153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="350" mass="38411" checksum="6F81AF5E54DD0409" modified="2024-10-02" version="1">MMLTHLAAVLFGLSAADAALTYKGVDWSSVAIEERAGVSYKNANGNAQPLEKILADNGVNTVRQRVWVNPADGNYNLDYNIALAKRAKAVGLGVYIDFHYSDTWADPSHQTAPSGWPTDIENLSWKLYNYTLDAANRFQDAGVQPTIMSIGNEITSGLLWPTGKTDNFGSIARLLHSAAWGIKDSRLSSKPKIMVHLDNGWNWETQNWWYTNALKQGTFALADFDMMGVSFYPFYSASASLDALKTSLANMARTWNKDVAVVETNWPTSCPSPKYAFPSDVKNIPFSAAGQTTYVTNVANVVSSVTRGVGLFYWEPAWIHNANLGSSCADNTMFSQSGQALSSLSVFRKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PED9</accession>
    <name>A0AAN6PED9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Isoleucine--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="3">6.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Isoleucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">C8A01DRAFT_48018</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>tRNA(Ile) + L-isoleucine + ATP = L-isoleucyl-tRNA(Ile) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:9666"/>
            <dbReference type="Rhea" id="RHEA-COMP:9695"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78528"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.5" evidence="3"/>
    <dbReference type="EMBL" id="MU854431">
        <property type="protein sequence ID" value="KAK4038385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001401">
        <property type="term" value="C:SAM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004822">
        <property type="term" value="F:isoleucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006428">
        <property type="term" value="P:isoleucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07960">
        <property type="entry name" value="Anticodon_Ia_Ile_BEm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03078">
        <property type="entry name" value="GST_N_Metaxin1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000111">
        <property type="entry name" value="Mitochondrial isoleucyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.830">
        <property type="entry name" value="Ile-tRNA synthetase CP2 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033708">
        <property type="entry name" value="Anticodon_Ile_BEm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002301">
        <property type="entry name" value="Ile-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050081">
        <property type="entry name" value="Ile-tRNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019564">
        <property type="entry name" value="Sam37/metaxin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00392">
        <property type="entry name" value="ileS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42765:SF1">
        <property type="entry name" value="ISOLEUCINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42765">
        <property type="entry name" value="SOLEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10568">
        <property type="entry name" value="Tom37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00984">
        <property type="entry name" value="TRNASYNTHILE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mitochondrial outer membrane transport complex Sam37/metaxin N-terminal" evidence="15">
        <location>
            <begin position="21"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="13">
        <location>
            <begin position="418"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="14">
        <location>
            <begin position="1094"/>
            <end position="1183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00068280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF10568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK4038385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1342" mass="146803" checksum="F634C101932F45F0" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PEU8</accession>
    <name>A0AAN6PEU8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SIT4 phosphatase-associated protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_18542</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SAPS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854469">
        <property type="protein sequence ID" value="KAK4034697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PEU8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019903">
        <property type="term" value="F:protein phosphatase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007587">
        <property type="entry name" value="SAPS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12634:SF8">
        <property type="entry name" value="FIERY MOUNTAIN, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12634">
        <property type="entry name" value="SIT4 YEAST -ASSOCIATING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04499">
        <property type="entry name" value="SAPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="69"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="421"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="470"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="545"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="920"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="994"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1192"/>
            <end position="1224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="92"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="515"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="545"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="588"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="616"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="638"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="662"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="927"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="951"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="962"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1003"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1040"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1092"/>
            <end position="1110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4034697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1279" mass="137888" checksum="E1507F0BDFC727BA" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PF00</accession>
    <name>A0AAN6PF00_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">H/ACA ribonucleoprotein complex subunit CBF5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Centromere-binding factor 5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">H/ACA ribonucleoprotein complex subunit cbf5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">H/ACA snoRNP protein CBF5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Small nucleolar RNP protein CBF5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">C8A01DRAFT_47077</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs and play a central role in ribosomal RNA processing. The H/ACA snoRNP complex also mediates pseudouridylation of other types of RNAs. Catalyzes pseudouridylation at position 93 in U2 snRNA. Also catalyzes pseudouridylation of mRNAs; H/ACA-type snoRNAs probably guide pseudouridylation of mRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a uridine in mRNA = a pseudouridine in mRNA</text>
            <dbReference type="Rhea" id="RHEA:56644"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:14659"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>uridine in 5S rRNA = pseudouridine in 5S rRNA</text>
            <dbReference type="Rhea" id="RHEA:47036"/>
            <dbReference type="Rhea" id="RHEA-COMP:11730"/>
            <dbReference type="Rhea" id="RHEA-COMP:11731"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>uridine in snRNA = pseudouridine in snRNA</text>
            <dbReference type="Rhea" id="RHEA:51124"/>
            <dbReference type="Rhea" id="RHEA-COMP:12891"/>
            <dbReference type="Rhea" id="RHEA-COMP:12892"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the pseudouridine synthase TruB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854400">
        <property type="protein sequence ID" value="KAK4039432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PF00"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000495">
        <property type="term" value="P:box H/ACA sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031118">
        <property type="term" value="P:rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02572">
        <property type="entry name" value="PseudoU_synth_hDyskerin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21148">
        <property type="entry name" value="PUA_Cbf5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2350.10:FF:000001">
        <property type="entry name" value="H/ACA ribonucleoprotein complex subunit CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="entry name" value="PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012960">
        <property type="entry name" value="Dyskerin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002501">
        <property type="entry name" value="PsdUridine_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004802">
        <property type="entry name" value="tRNA_PsdUridine_synth_B_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032819">
        <property type="entry name" value="TruB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004521">
        <property type="entry name" value="Uncharacterised_CHP00451"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00425">
        <property type="entry name" value="CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003280">
        <property type="entry name" value="PRK04270.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00451">
        <property type="entry name" value="unchar_dom_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23127">
        <property type="entry name" value="CENTROMERE/MICROTUBULE BINDING PROTEIN CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23127:SF0">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT DKC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08068">
        <property type="entry name" value="DKCLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16198">
        <property type="entry name" value="TruB_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01509">
        <property type="entry name" value="TruB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01136">
        <property type="entry name" value="DKCLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
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    <feature type="chain" id="PRO_5042889601" description="H/ACA ribonucleoprotein complex subunit CBF5" evidence="14">
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            <begin position="23"/>
            <end position="1004"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Dyskerin-like" evidence="16">
        <location>
            <begin position="550"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="domain" description="PUA" evidence="15">
        <location>
            <begin position="801"/>
            <end position="875"/>
        </location>
    </feature>
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        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
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        <location>
            <begin position="937"/>
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        </location>
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        </location>
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        <source>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM01136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK4039432.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1004" mass="109571" checksum="5778ACC976BD4922" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PFK4</accession>
    <name>A0AAN6PFK4_9PEZI</name>
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        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="ORF">C8A01DRAFT_47274</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN ZNTC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042913874" evidence="3">
        <location>
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            <end position="497"/>
        </location>
    </feature>
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            <end position="205"/>
        </location>
    </feature>
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        </location>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="497" mass="51881" checksum="8CF7B309476F462E" modified="2024-10-02" version="1">MVLNRHALALTAAMATARAAAPSPPEKRQAAITVVSTCHMHCTRLYCMVGATEYVLADAAVTPATTTAPSDAASTSVTAVTDCHLHDTQYKVSTTATATADLPLMYAGCHSHDSDTYCLSPSGNDVQIQLASEEDEGDASEPVEENCHFHANVEHCVGGSGESGTCSCERTDREYNVPLRIGLLFTILVTSVCPPFCVFAPIVLAKFLSSRANTALLIIKQFGPGVLMSTSLVHLFTHAELMFGSECLGELQYEATTAAILMAGLFLSFLIEYLGYRFVERQARKAAAAQGMQGGMVPVQNLKSLEMVSVYVMEAGVIFYSLIIGLTLVVASDSFLLTLFIGLVLGSRIAALGTGSNSSFSVLGHSHASPSIDISSSGKTTGDEDNMPGTRPEDAPAEGKVLFHVPMAKKMCLAGAFALVTPVSMAIGIGVLDVLHGNDPQTIVAVGVLDAFSAGILLWAAGWVYGGGLADASAVATCLGLGGLVAGMVMSVLGKWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAN6PFP9_9PEZI</name>
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        <recommendedName>
            <fullName evidence="2">AAA+ ATPase domain-containing protein</fullName>
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        <name evidence="3" type="ORF">C8A01DRAFT_35852</name>
    </gene>
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        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854383">
        <property type="protein sequence ID" value="KAK4040164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PFP9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19481">
        <property type="entry name" value="RecA-like_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056599">
        <property type="entry name" value="AAA_lid_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054289">
        <property type="entry name" value="DUF7025"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411:SF2">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411">
        <property type="entry name" value="FAMILY ATPASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23232">
        <property type="entry name" value="AAA_lid_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22942">
        <property type="entry name" value="DUF7025"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="2">
        <location>
            <begin position="625"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4040164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="862" mass="97804" checksum="6D632A1526EA6A53" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PG90</accession>
    <name>A0AAN6PG90_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">DnaJ-related protein SCJ1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">C8A01DRAFT_46371</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854380">
        <property type="protein sequence ID" value="KAK4040301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PG90"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.230.10:FF:000001">
        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044713">
        <property type="entry name" value="DNJA1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43888">
        <property type="entry name" value="DNAJ-LIKE-2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042820944" evidence="8">
        <location>
            <begin position="21"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="9">
        <location>
            <begin position="23"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="10">
        <location>
            <begin position="147"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="6">
        <location>
            <begin position="147"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="400"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK4040301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="423" mass="47523" checksum="5654B28BD7103528" modified="2024-10-02" version="1">MRLLKTILLSLLTLAQIALCAEDYYKVLGLDKQASERQIKSAYRQLSKKYHPDKNPNDPTAHDKFVLVAEAYEALSDAESRQIYDQYGHEGLKQRKQQGGSGGGHDPFDLFSRFFGGGGHYGNQPGQRRGHNVEVKVPISLRDFYNGRTTEFQWNKQEICEACEGTGAADRVVHTCQTCGGRGVRTVRQQLAPGMVTQVQMQCDACGGRGKSIKHRCSACGGERVVRKPTLVSLTVQRGMADGSRVAYENEADASPDYVAGDLIVTLFEKEPGLEGEDNPDKVDGVFFRRKGDDLFWREILSLREALMGDWTRNITHLDGHVVRLGRKRGQVVQPGHVETVAGEGMPKWDEDGDSVYHKTEFGNLFVEYTVVLPDQMDSGMEKELWALFQKWRAKKGVDLHKDSGRPEKPVIHDEHEHEHEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PHB8</accession>
    <name>A0AAN6PHB8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_15418</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854370">
        <property type="protein sequence ID" value="KAK4040757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PHB8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000481">
        <property type="entry name" value="Alcohol dehydrogenase, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052711">
        <property type="entry name" value="Zinc_ADH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033:SF3">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G13270)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="12"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4040757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="366" mass="38821" checksum="52A63428974706E9" modified="2024-10-02" version="1">MPYSLTVKKTEGKPGQVYYPLQLNTIPLPSPGPGQLLIKLSAAALNHRDLFIRQHLYPGISFTAPLLADGYGTVSALGPSCSTFSQSLLNTPVLLLPTRGWTAAPDGPENLARDFCIIGAAQGTPVGTAQEYVVVDEGDVVPAPEHLTPCEGAALPLVGVTGWRALVTKSGGNAEPGRNLLVTGIGGGVALQVLLFAVARGCNVWVTSGDEGKIERAVGMGARGGVNYKEQGWEKKLAGMLPEERPYLDAVIDGAGGEVVGKTVRLLKPGGVISCYGMTVGPKMDWVIQATLKHVELRGTTMGSKKEFEEMVAFVREHKIRPVVSRVVKGLDNIEGIDSLFEDMKAGRQFGKLVIQIDGEDSAPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PHH8</accession>
    <name>A0AAN6PHH8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Fungal-specific transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_45800</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854366">
        <property type="protein sequence ID" value="KAK4040976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PHH8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF50">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="66"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="92"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="170"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="892"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="50"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="268"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="895"/>
            <end position="916"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4040976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="982" mass="109400" checksum="2EB0D50D68A7D23E" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PHR5</accession>
    <name>A0AAN6PHR5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_15218</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the shaker potassium channel beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854366">
        <property type="protein sequence ID" value="KAK4040967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PHR5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19143">
        <property type="entry name" value="AKR_AKR6C1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005399">
        <property type="entry name" value="K_chnl_volt-dep_bsu_KCNAB-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43150">
        <property type="entry name" value="HYPERKINETIC, ISOFORM M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43150:SF2">
        <property type="entry name" value="HYPERKINETIC, ISOFORM M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01577">
        <property type="entry name" value="KCNABCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="4">
        <location>
            <begin position="32"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4040967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="352" mass="39022" checksum="948E02A476869211" modified="2024-10-02" version="1">MAAPTVPTAYDPKGMKFRYLGNTGLQVSVFSLGGWLTYGGTQKGSIVKEILQTAWDHGIQTFDTAETYANGASEVEMGAALKELGWPRDEYVLTTKVFFGTGRKEPNTRGLSRKHVVEGLKASLARLQTPYVDVVFAHRPDPATPMLEIVEAFTQTIRNLNLAYYWGTSEWSAAQITEAIGLAEKHHLIAPVVEQPQYNAFHRERFEVEYAPLFRQHGYGTTIWSPLASGLLTGKYNDGIPQDSRFATNKAFFESTIKELQSEQGQAKLEKVRKLTKIAERLGATATHLALAWAAKNPNVSTVILGATKIEQVLDNLKALDVIDKLTPEIMEEIEGVLDNKPKGVATWGRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PI27</accession>
    <name>A0AAN6PI27_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">High-affinity nicotinic acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_14869</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854358">
        <property type="protein sequence ID" value="KAK4041364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PI27"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000018">
        <property type="entry name" value="MFS transporter permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF27">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G15730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="293"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="327"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="360"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="390"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="425"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="457"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4041364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="523" mass="57106" checksum="CD6100185CBA469B" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PIC7</accession>
    <name>A0AAN6PIC7_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">C8A01DRAFT_16482</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854398">
        <property type="protein sequence ID" value="KAK4039539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PIC7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4039539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="96" mass="10311" checksum="87CCD531333A880E" modified="2024-10-02" version="1">MPFGFSFSSSTSAVVVASGSVNGHSAAEGWAYKREAYSNSNGSGVRTIKQKLGEAPVMQTRMYDAHGRPLFIEGSDRPRGPDDSVMRIKDVAEGRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PIP1</accession>
    <name>A0AAN6PIP1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">SMP-LTD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">C8A01DRAFT_35253</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854371">
        <property type="protein sequence ID" value="KAK4040695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PIP1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032865">
        <property type="term" value="C:ERMES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990456">
        <property type="term" value="P:mitochondrion-endoplasmic reticulum membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015914">
        <property type="term" value="P:phospholipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21675">
        <property type="entry name" value="SMP_TEX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058801">
        <property type="entry name" value="PDZD8_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13466:SF19">
        <property type="entry name" value="NUCLEUS-VACUOLE JUNCTION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13466">
        <property type="entry name" value="TEX2 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26547">
        <property type="entry name" value="PDZD8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15413">
        <property type="entry name" value="PH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SMP-LTD" evidence="10">
        <location>
            <begin position="281"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="37"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="573"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="767"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="615"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="649"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="662"/>
            <end position="674"/>
        </location>
    </feature>
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        <location>
            <begin position="676"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="722"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="793"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="826"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="874"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="898"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="922"/>
            <end position="932"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK4040695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="974" mass="105237" checksum="C48286AAC84BEE1C" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PJ30</accession>
    <name>A0AAN6PJ30_9PEZI</name>
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        <submittedName>
            <fullName evidence="7">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_45226</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
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            <taxon>Ascomycota</taxon>
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            <taxon>Sordariomycetidae</taxon>
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            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAK4041687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000594">
        <property type="entry name" value="Small nucleolar ribonucleoprotein complex subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
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    </dbReference>
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        <property type="entry name" value="Rrp9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19865">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19865:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="239"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="281"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="323"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="384"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="459"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="199"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="432"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="501"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="582"/>
            <end position="602"/>
        </location>
    </feature>
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        <location>
            <begin position="31"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="206"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="501"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4041687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="602" mass="66196" checksum="01251B5A4BEA200D" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PJ48</accession>
    <name>A0AAN6PJ48_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_14677</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854354">
        <property type="protein sequence ID" value="KAK4041607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PJ48"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4041607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="119" mass="12484" checksum="0712A401A5BBDC27" modified="2024-10-02" version="1">MSTSTAPQTHPENKPPGPGDTIADLAASLLSSPKHTHSHHHTTTTTTNNNNNHDGSGNSGQEKSASAARAMSHTGAWKPALDGRQSWSAQEYKHDLLKRQYMAAGPGEEAGKGGGFSEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAN6PJG5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_33758</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854345">
        <property type="protein sequence ID" value="KAK4042123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PJG5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
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        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050432">
        <property type="entry name" value="FAD-linked_Oxidoreductases_BP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878:SF91">
        <property type="entry name" value="FAD BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G12070)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878">
        <property type="entry name" value="GULONOLACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043032670" description="FAD-binding PCMH-type domain-containing protein" evidence="4">
        <location>
            <begin position="20"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="5">
        <location>
            <begin position="126"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4042123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="599" mass="64593" checksum="189FE734E2ED5575" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PJH2</accession>
    <name>A0AAN6PJH2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_34832</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854363">
        <property type="protein sequence ID" value="KAK4041100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PJH2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4041100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="73" mass="8247" checksum="EF35FD7F99E4419A" modified="2024-10-02" version="1">MPLSTTLEPIFPEFRAPTYFANDKPVLDSNGKPATQPVFPVSTLAWANTRDAEGLSETYWKSAEDPEWFGKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PK88</accession>
    <name>A0AAN6PK88_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Oxidoreductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_35965</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854386">
        <property type="protein sequence ID" value="KAK4040000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PK88"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF283">
        <property type="entry name" value="RETINOL DEHYDROGENASE 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4040000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="326" mass="35369" checksum="657FD19BD39CF568" modified="2024-10-02" version="1">MSAQYNFHTTGSELVRDLATAIKDKVILTTGVSPGGLGAEFVTALAAANPSLLILAGRNTTKVQQTADAIAQAHPGVKTRLLRLDLTSLSAVREAAAEVNAWDDVPAIDVLVNNAGIMAVEHAVTEDGFESQFAVNHLAHFLFTNLIMGKVLAAAKPRVVNVSSDGHRMSGIRFGDLDFRGGENYNKWHAYGQSKTANMLMALSLAEKLGKKGLRAYSLHPGVIGTNLGNHLDWSVDIPGMHAEDQVLGNKEGWEEFKFKTTDQGIATHVFAAFHPSLEDHNGAYLQDSHIADPWTETVKPWATSSIEAERLWKLSEKLVGQEFAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PL35</accession>
    <name>A0AAN6PL35_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Flavin-dependent halogenase/O-methyltransferase bifunctional protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">C8A01DRAFT_33899</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the flavin-dependent halogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854347">
        <property type="protein sequence ID" value="KAK4042015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PL35"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012967">
        <property type="entry name" value="COMT_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050816">
        <property type="entry name" value="Flavin-dep_Halogenase_NPB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43747:SF5">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43747">
        <property type="entry name" value="FAD-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08100">
        <property type="entry name" value="Dimerisation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FAD-binding" evidence="9">
        <location>
            <begin position="7"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="O-methyltransferase dimerisation" evidence="10">
        <location>
            <begin position="666"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="8">
        <location>
            <begin position="840"/>
            <end position="983"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK4042015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1005" mass="108301" checksum="361AC3F43E78B7B8" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PL58</accession>
    <name>A0AAN6PL58_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Saponin hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_13576</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854335">
        <property type="protein sequence ID" value="KAK4042812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PL58"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042904087" evidence="2">
        <location>
            <begin position="18"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="396"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4042812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="625" mass="66663" checksum="04EC5E08042E7233" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2025-10-08" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PLC9</accession>
    <name>A0AAN6PLC9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_13394</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854332">
        <property type="protein sequence ID" value="KAK4043061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:mitotic actomyosin contractile ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:mitotic division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="CAP/Cytokinesis_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035553">
        <property type="entry name" value="Cyk3_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056409">
        <property type="entry name" value="Ig_CYK3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46333">
        <property type="entry name" value="CYTOKINESIS PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46333:SF2">
        <property type="entry name" value="CYTOKINESIS PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24584">
        <property type="entry name" value="Ig_CYK3_C"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="11"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="74"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="121"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="297"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="564"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="692"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1164"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="76"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="123"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="272"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="318"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="360"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="476"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="528"/>
            <end position="547"/>
        </location>
    </feature>
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        <location>
            <begin position="564"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="692"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1164"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1192"/>
            <end position="1211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4043061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1315" mass="143614" checksum="A3DBC3ABE00B9186" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PM14</accession>
    <name>A0AAN6PM14_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sexual differentiation process protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_33467</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854340">
        <property type="protein sequence ID" value="KAK4042525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PM14"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00727">
        <property type="entry name" value="ISP4_OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="284"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="356"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="433"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="486"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="512"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="544"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
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            <end position="618"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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            <begin position="639"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="668"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="691"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="713"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="741"/>
            <end position="765"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4042525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="806" mass="91641" checksum="AEBFA10F2223DA1C" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PM31</accession>
    <name>A0AAN6PM31_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_14674</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854354">
        <property type="protein sequence ID" value="KAK4041594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PM31"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027796">
        <property type="entry name" value="OTT_1508_deam-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42037">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42037:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14441">
        <property type="entry name" value="OTT_1508_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="443"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="463"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="504"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="521"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4041594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="534" mass="59865" checksum="314C4E31BD1FC65D" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PM56</accession>
    <name>A0AAN6PM56_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_13067</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854328">
        <property type="protein sequence ID" value="KAK4043367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PM56"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="122"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="258"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="336"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="505"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4043367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="558" mass="64848" checksum="481A8DBB2FCCA188" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PMA8</accession>
    <name>A0AAN6PMA8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Acetyl-CoA carboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">C8A01DRAFT_34827</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>N(6)-biotinyl-L-lysyl-[protein] + hydrogencarbonate + ATP = N(6)-carboxybiotinyl-L-lysyl-[protein] + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13501"/>
            <dbReference type="Rhea" id="RHEA-COMP:10505"/>
            <dbReference type="Rhea" id="RHEA-COMP:10506"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83144"/>
            <dbReference type="ChEBI" id="CHEBI:83145"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.14"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>hydrogencarbonate + acetyl-CoA + ATP = malonyl-CoA + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11308"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.4.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854363">
        <property type="protein sequence ID" value="KAK4041095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004075">
        <property type="term" value="F:biotin carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06850">
        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.460.10:FF:000001">
        <property type="entry name" value="Acetyl-CoA carboxylase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000005">
        <property type="entry name" value="Acetyl-CoA carboxylase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000005">
        <property type="entry name" value="Acetyl-CoA carboxylase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000003">
        <property type="entry name" value="acetyl-CoA carboxylase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000005">
        <property type="entry name" value="acetyl-CoA carboxylase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000010">
        <property type="entry name" value="acetyl-CoA carboxylase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.460.10">
        <property type="entry name" value="Biotin dependent carboxylase carboxyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1770.10">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049076">
        <property type="entry name" value="ACCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049074">
        <property type="entry name" value="ACCA_BT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013537">
        <property type="entry name" value="AcCoA_COase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45728:SF3">
        <property type="entry name" value="ACETYL-COA CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45728">
        <property type="entry name" value="ACETYL-COA CARBOXYLASE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08326">
        <property type="entry name" value="ACC_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21385">
        <property type="entry name" value="ACCA_BT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
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</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PMB1</accession>
    <name>A0AAN6PMB1_9PEZI</name>
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        <recommendedName>
            <fullName evidence="2">UBA domain-containing protein</fullName>
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        <name type="scientific">Parachaetomium inaequale</name>
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            <taxon>Sordariomycetidae</taxon>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">CBS 284.82</strain>
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        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
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                <person name="Cros-Aarteil S."/>
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                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
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        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="37"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="73"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="571"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="701"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="78"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="621"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="731"/>
            <end position="743"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4043803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="788" mass="87814" checksum="0DB6263220E44DD8" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PMR7</accession>
    <name>A0AAN6PMR7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">lytic cellulose monooxygenase (C4-dehydrogenating)</fullName>
            <ecNumber evidence="15">1.14.99.56</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">C8A01DRAFT_13489</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the polysaccharide monooxygenase AA9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="15"/>
    <dbReference type="EMBL" id="MU854334">
        <property type="protein sequence ID" value="KAK4042870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PMR7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF13">
        <property type="entry name" value="ENDOGLUCANASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042815429" description="lytic cellulose monooxygenase (C4-dehydrogenating)" evidence="17">
        <location>
            <begin position="16"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="18">
        <location>
            <begin position="274"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="235"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="255"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAK4042870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="310" mass="31715" checksum="3945A739297CC2EB" modified="2024-10-02" version="1">MKPFTLVALATAVSGHAIFQRVSVNGQDQGQLKGVRAPYSNTPIQNVNSADMACNANLQLLDSTVIKVPAGARVGAWWQHEIGGPSGPNDADNPIAASHKGPIMVYLAKVDNAASASTSGQKWFKIAERGVSNGVWAVDEMIANNGWHYFDMPSCVAPGQYLMRVELLALHSASTAGGAQFYMECAQIEVTGSGTNTGSSGTVSFPGAYPANHPGIVVSIYDSTGQPTMNGRTYQIPGPAPITCSGGSNNGGGSSPTTTAGGSQSTNGGGSTGGSVPLYGQCGGNGYTGPTGCAQGTCKAQNEWYSQCTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PNJ7</accession>
    <name>A0AAN6PNJ7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcription factor TFIID-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_31559</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854320">
        <property type="protein sequence ID" value="KAK4044246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PNJ7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04516">
        <property type="entry name" value="TBP_eukaryotes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000001">
        <property type="entry name" value="TATA-box-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000002">
        <property type="entry name" value="TATA-box-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00408">
        <property type="entry name" value="TATA_bind_prot_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000814">
        <property type="entry name" value="TBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030491">
        <property type="entry name" value="TBP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033710">
        <property type="entry name" value="TBP_eukaryotic"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10126">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00352">
        <property type="entry name" value="TBP"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="TIFACTORIID"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55945">
        <property type="entry name" value="TATA-box binding protein-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00351">
        <property type="entry name" value="TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4044246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="256" mass="27532" checksum="7D9089FDF0CAF32F" modified="2024-10-02" version="1">MEAIQTHPSNAAQAKAFTAPGSLSFPGGANEFANPAAQANGMATIGVPQQGVQATNGTGVTPATPAATPGAGPTGPSGITPTLQNIVATVNLDCRLDLKTIALHARNAEYNPKRFAAVIMRIREPKTTALIFASGKMVVTGAKSEDDSKLASRKYARIIQKLGFNAKFTDFKIQNIVGSCDIKFPIRLEGLASKHHNFSSYEPELFPGLIYRMIKPKIVLLIFVSGKIVLTGAKVREEIYQAFEMIYPVLQDFRKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PP63</accession>
    <name>A0AAN6PP63_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_32379</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854327">
        <property type="protein sequence ID" value="KAK4043453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PP63"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4043453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="360" mass="39568" checksum="74125666AF6C1142" modified="2024-10-02" version="1">MPTKTREYYLTTSSSRDFTWSFFKPASPQHSRSKPDPPPPNRAPDARRAKRLSVTEEQGQALMAPADVKARAQARSKPTKAKRPKPKKTGPKNAGPWSDWYVSDDRNYFWRARKAQNETWDYQLTPGYQEPAPTQDITPATSGGELGRPLSPIPESPPGCPSPSPSLPRDPTSPKSSWPTIITTSTGYPTEDLSASSSRTLVTLPREAEDSYQPGTALVPFVVTTNSSRTKTNDTKRSSNSKRPVGPVMRLLQEGRSRKNRARTEVTQSTANNTAAMTGTSGGKPQQGGNYANNGNFGTGGVTVIKNRTASSFARKLHAKVKSEKELKVDPKKRVRMWLKGVEVDLAPMPLDAQGFPIYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PPT4</accession>
    <name>A0AAN6PPT4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dynamin family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_33471</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854341">
        <property type="protein sequence ID" value="KAK4042400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PPT4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF215">
        <property type="entry name" value="DYNAMIN GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="5">
        <location>
            <begin position="33"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="4">
        <location>
            <begin position="654"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="136"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4042400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="742" mass="83749" checksum="7CFC1A5563E36B34" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PPX9</accession>
    <name>A0AAN6PPX9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_31927</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854322">
        <property type="protein sequence ID" value="KAK4044055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PPX9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4044055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="259" mass="27987" checksum="54CFDBC2473ED59C" modified="2024-10-02" version="1">MSFACTEAFGKRELGGETYPILRFRVDDPENDTTALGLIIQSAERHSMSISSASPPTPKSSQPSAPQLPTPPSSEQPRGKRQASSSPSGKPLGSRRKPASPEPQTMDERAEHAGSDAAPDDPSELQPKRDGTAPFKEQLPGCVNPGDLYRSPYSADDFQPRLPLIDITTALSRREATMDPDSLVFSETADSLDDIFFRPSTPSARPPAQDEAKLTFGAVGVDPDRGPEYPWEVPDGELDGDERDDDGEFAGLLNFMAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PQ12</accession>
    <name>A0AAN6PQ12_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribosomal RNA-processing protein 43</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">C8A01DRAFT_33446</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854340">
        <property type="protein sequence ID" value="KAK4042505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PQ12"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034473">
        <property type="term" value="P:U1 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034476">
        <property type="term" value="P:U5 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050590">
        <property type="entry name" value="Exosome_comp_Rrp42_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097:SF9">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0271">Exosome</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="12" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="11">
        <location>
            <begin position="47"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="173"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="173"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="191"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK4042505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="362" mass="39637" checksum="1E5BAF0E13A48E96" modified="2024-10-02" version="1">MTAPTIKLPAPLFAKLSPHPFLLRNLTSAADPSLPPARTNGRGTQDTRPLHIKASSLSHAHGSSLVRLGDTTVLCGVRGELLPVERIPQFRPVEGTREDVESGGDDGVIAGRGEMRDYDLLVPNIELATGSAPQFLPGVPPTALAQTLSTRVYSLLHSTGLVGVRDLRVWCNPKKDGEGKEGGEDVKMEGAEEEEEEQDGVLEEDRVVAYWVLYIDLLFVSFDGNPFDAAWAAVVAALRNTRLPVARWDPEREMVVCSRTERRKLDVRGLPVACTAAVFEEKELGEVGTGVVEGRHWLLLDPDRLEETLCREAITMVVDCSDGETRIKSIEKQGGTSIGRELVRGFAGIAEKRWQEVKKAMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PQ14</accession>
    <name>A0AAN6PQ14_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">cAMP-dependent protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">C8A01DRAFT_32660</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.11" evidence="1"/>
    <dbReference type="EMBL" id="MU854330">
        <property type="protein sequence ID" value="KAK4043169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PQ14"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004691">
        <property type="term" value="F:cAMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05580">
        <property type="entry name" value="STKc_PKA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000005">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000005">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353:SF153">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="183"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="13">
        <location>
            <begin position="439"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="80"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="119"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK4043169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="494" mass="55184" checksum="F348C7A2B0C5CBBF" modified="2024-10-02" version="1">MHALGGFLRRKRTRDGNPGHSSPSNPTSPVTSTAGSFDQGAVPRGSRSSAASSQSTHRSSGTAAQLNKPAEAAAQQQQQPMNTLSAQPPSTAVPVQHTPSPGTDPQKGPQISNLINPPQQEGGYQHHQGGQYTNNGGATSNQPQQQQQPQHQNQNQTQQQTQVAAQQLSEARVTKGKYSLADFELLRTLGTGSFGRVHLVQSRHNHRFYAIKVLKKAQVVKMKQVEHTNDERKMLGEVKHPFLITLWGTFQDPRNLYMVMDFVEGGELFSLLRRSGRFPNPVAKFYAAEVTLALEYLHSRNIIYRDLKPENLLLDRHGHLKITDFGFAKRVPDKTWTLCGTPDYLAPEVVSNKGYNKSVDWWSLGILIYEMLCGYTPFWDSGSPMKIYENILRGKVKYPAYVNPDAQNLLERLITADLTKRLGNLYGGSQDVKNHPWFAEVTWDRLARKDIDAPYSPPVRAGAGDASQFDRYPEETEQYGAGGHDEYGHMFQDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PR32</accession>
    <name>A0AAN6PR32_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">U3-containing 90S pre-ribosomal complex subunit-domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_12688</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854324">
        <property type="protein sequence ID" value="KAK4043724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PR32"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032704">
        <property type="entry name" value="Cms1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24030">
        <property type="entry name" value="PROTEIN CMSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24030:SF0">
        <property type="entry name" value="PROTEIN CMSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14617">
        <property type="entry name" value="CMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4043724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="250" mass="28421" checksum="0AB193159C34FDCD" modified="2024-10-02" version="1">MSTEERANKRKLQDDDRPRKKQKKQKKVREDEGDLDVEAGLNRAFARMDGQLVADHIAQKTLRFGTDLSPVELADLYISANSIRDSTSWEKPRSLENLPDFLEQFAGESEKLDQAPKKAGSPHTLIVAGAGLRAADLVRAVRKFQTKKNSVAKLFAKHFKLEEQVSFLQKSRTGIAVGTPQRLIDLIENDALSLDNLKRIIVDASHIDQKKRGIVDMRETMLPLAKLLCREALKERYEDETVKHIDLIFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PTV0</accession>
    <name>A0AAN6PTV0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Urease</fullName>
            <ecNumber evidence="2">3.5.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Urea amidohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">C8A01DRAFT_42654</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>urea + 2 H2O + H(+) = hydrogencarbonate + 2 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:20557"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Ni cation</name>
            <dbReference type="ChEBI" id="CHEBI:25516"/>
        </cofactor>
        <text evidence="10">Binds 2 nickel ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nitrogen metabolism; urea degradation; CO(2) and NH(3) from urea (urease route): step 1/1.</text>
    </comment>
    <comment type="PTM">
        <text evidence="9">Carbamylation allows a single lysine to coordinate two nickel ions.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.5" evidence="2"/>
    <dbReference type="EMBL" id="MU854318">
        <property type="protein sequence ID" value="KAK4044470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035550">
        <property type="term" value="C:urease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009039">
        <property type="term" value="F:urease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043419">
        <property type="term" value="P:urea catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00375">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00407">
        <property type="entry name" value="Urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00390">
        <property type="entry name" value="Urease_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.280.10:FF:000001">
        <property type="entry name" value="Urease subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.150.10">
        <property type="entry name" value="Urease, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.280.10">
        <property type="entry name" value="Urease, gamma-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01953">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011612">
        <property type="entry name" value="Urease_alpha_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050112">
        <property type="entry name" value="Urease_alpha_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017950">
        <property type="entry name" value="Urease_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005848">
        <property type="entry name" value="Urease_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017951">
        <property type="entry name" value="Urease_asu_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002019">
        <property type="entry name" value="Urease_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036461">
        <property type="entry name" value="Urease_betasu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002026">
        <property type="entry name" value="Urease_gamma/gamma-beta_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036463">
        <property type="entry name" value="Urease_gamma_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029754">
        <property type="entry name" value="Urease_Ni-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009671">
        <property type="entry name" value="PRK13192.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009686">
        <property type="entry name" value="PRK13207.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01792">
        <property type="entry name" value="urease_alph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00192">
        <property type="entry name" value="urease_beta"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01120">
        <property type="entry name" value="UREASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 10" id="KW-0533">Nickel</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Urease" evidence="15">
        <location>
            <begin position="975"/>
            <end position="1411"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="90"/>
            <end position="191"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="56"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="105"/>
            <end position="117"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="132"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11 12">
        <location>
            <position position="1166"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="980"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
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        <location>
            <position position="982"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
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        <location>
            <position position="1063"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>2</label>
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        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
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        <ligand>
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        <ligand>
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            <position position="1206"/>
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        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
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            <position position="1063"/>
        </location>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51368"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK4044470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1411" mass="153953" checksum="05C7DA61C0FA87F8" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SLA9</accession>
    <name>A0AAN6SLA9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_42244</name>
    </gene>
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        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Chaetomiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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            <end position="80"/>
        </location>
    </feature>
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        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="100"/>
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        </location>
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    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="KAK4031290.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="167" mass="18709" checksum="BEFCC01225C20847" modified="2024-10-02" version="1">MPFTLFPNLPTELRLQIWLLYFESPRIHILHDTKDADANPDRVLLTCTTIDAQTSIPLPPRIRTDISREAQSVALSLKQPRERIRTLTTPVAYKRIHDPTWRDPSAHARGEHAQPEPVDVDWGQRPDSRLQPEVNLPLHGAGATAVGEQGAEPRGGAAVADAWRRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SLE4</accession>
    <name>A0AAN6SLE4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heterokaryon incompatibility protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">C8A01DRAFT_51128</name>
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        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854670">
        <property type="protein sequence ID" value="KAK4031964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SLE4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF11">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="19"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4031964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="332" mass="37658" checksum="D661908C58E786DF" modified="2024-10-02" version="1">MDQAVRLAITETSQCEGHYTTLSHRWGIGPIYTLTSATLPTLLAGVRISELPQTFREAIEITRRLGVRYLWIDSMCIIQDSADDWQKESAQMVHVYSHSHLNIAATASDNAQQGLFRRRQRSWVMQERFLAPRVVHFVASQLFWECHQRTASEILDPDYLAQTDILLSSVHPSQFPFEMWDRMDKLVAIGGLAQHIARMVGHADTYLAGLWKSRLPRQLLWSVAGCEQAGRAPSYRPPVYRAPSWSWASVEARVTVFEYEDRYKKTHDLLIVKDVSVTPLGGGDVFGQLVGGSIKNKMRAGIRCIYPQTCLKTALLWLTAWLSCTVKCMTAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SLF4</accession>
    <name>A0AAN6SLF4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WSC-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_21343</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854816">
        <property type="protein sequence ID" value="KAK4031425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SLF4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051836">
        <property type="entry name" value="Kremen_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24269">
        <property type="entry name" value="KREMEN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24269:SF16">
        <property type="entry name" value="PROTEIN SLG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="WSC" evidence="7">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4031425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="89" mass="9478" checksum="8504D86EF90BEBE4" modified="2024-10-02" version="1" fragment="single">TSLGCWSDNHNRALQGRSTSSNSMTTEMCASFCSEFAIFGTEFGSQCFCGNVLWSGAQFEDPRVGCTSPCQGNGGETCGGTWALSIYTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SLY5</accession>
    <name>A0AAN6SLY5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TauD/TfdA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_50713</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854600">
        <property type="protein sequence ID" value="KAK4032519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SLY5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000005">
        <property type="entry name" value="TfdA family taurine dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF10">
        <property type="entry name" value="TAUD_TFDA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="7">
        <location>
            <begin position="34"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4032519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="359" mass="39892" checksum="570559E591AA500B" modified="2024-10-02" version="1">MAPSAIDIDIPVATKGPAREPLKLSGALDAYESFDVTPVIGREFPTAKLDEWLAGPNSDELLRDLAITISQRGVVFFRAQDGLTNELQKQLILRLGELTGRPATSGLHIHPILNSERDLGGNDLEISTISSVQNKKFYSKTVADTLSVKNQSSAQWHSDIAFEPVPADYTSLRLVELPTTGGDTLWASGYEIYDRISEPYQKFLESLTATFEQPGFQRVAEKSGFKIYDKPRGAPENVGGELKAVHPVVRTNPVTGWKSIFPVGGHVKHINGLTDEESSKLLSWFLDLVYKNHDLQVRLKWKNPNDIAIWDNRSVFHTATFDYQDGNYGERFGNRAVGLGERPYLDPNSTSRRAALHDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SN39</accession>
    <name>A0AAN6SN39_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heterokaryon incompatibility protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_18719</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854478">
        <property type="protein sequence ID" value="KAK4034481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SN39"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF73">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G01020)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26639">
        <property type="entry name" value="Het-6_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="57"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4034481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="666" mass="74109" checksum="BB497760FF8B9E59" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SNG5</accession>
    <name>A0AAN6SNG5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Orotidine 5'-phosphate decarboxylase</fullName>
            <ecNumber evidence="3">4.1.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">OMP decarboxylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Uridine 5'-monophosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">C8A01DRAFT_19024</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OMP decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.23" evidence="3"/>
    <dbReference type="EMBL" id="MU854494">
        <property type="protein sequence ID" value="KAK4034109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SNG5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004590">
        <property type="term" value="F:orotidine-5'-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04725">
        <property type="entry name" value="OMP_decarboxylase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014732">
        <property type="entry name" value="OMPdecase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018089">
        <property type="entry name" value="OMPdecase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001754">
        <property type="entry name" value="OMPdeCOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32119">
        <property type="entry name" value="OROTIDINE 5'-PHOSPHATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32119:SF2">
        <property type="entry name" value="OROTIDINE 5'-PHOSPHATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00215">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00934">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00156">
        <property type="entry name" value="OMPDECASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orotidine 5'-phosphate decarboxylase" evidence="13">
        <location>
            <begin position="37"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="164"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="170"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="182"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="219"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="active site" description="For OMPdecase activity" evidence="10">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <feature type="active site" description="For OMPdecase activity" evidence="10">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <feature type="active site" description="For OMPdecase activity" evidence="10">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR614732-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR614732-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK4034109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="385" mass="42523" checksum="AEF38E6428AB19DF" modified="2024-10-02" version="1">MADRHPTLAQPFAERAKTATHPLSRYLYRLMDLKASNLCLSADVTTARDLLTLADKVGPSIVVLKTHYDLIAGWDYNPQTGTGAKLAALARKHGFLIFEDRKFVDIGKTVQMQYTAGTARIVEWAHITNANIDAGKDMVRAMAEAAAKWKERIHYEVKTSVTVGTPVSDQFDDAEEQEQEEQAQRDRDEKGEPRRLDAKEQQHRRDSSKDVDGRKGSIVSITTVTQSFEPADSPRLSKTNEHGGDAVFPGIEEAPVDRGLLLLAQMSTKGCLMTRDYTQACVEAAREHRGFVMGYVAQEALNVAPDDNFIHMTPGCKLPPPGEEENGQVEGDGLGQQYNTPSRLIGVCGTDIVIVGRGIISADDPPSEAERYRRKAWKAYLARLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SNN3</accession>
    <name>A0AAN6SNN3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_39739</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854509">
        <property type="protein sequence ID" value="KAK4033810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SNN3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140115">
        <property type="term" value="P:export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042908">
        <property type="term" value="P:xenobiotic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF60">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="315"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="395"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="427"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="460"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="487"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="86"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4033810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="523" mass="57273" checksum="2C19EF559F0DA356" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SNY3</accession>
    <name>A0AAN6SNY3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_49283</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854485">
        <property type="protein sequence ID" value="KAK4034302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SNY3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="333"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="370"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="412"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4034302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="536" mass="59664" checksum="424212AC0F10B7C2" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SP99</accession>
    <name>A0AAN6SP99_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Fungal-specific transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_39024</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854477">
        <property type="protein sequence ID" value="KAK4034500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SP99"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF3">
        <property type="entry name" value="C6 FINGER DOMAIN TRANSCRIPTION FACTOR DBAA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="27"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4034500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="594" mass="65923" checksum="AF19D47963461602" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SPD2</accession>
    <name>A0AAN6SPD2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">ADP/ATP translocase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">ADP,ATP carrier protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">C8A01DRAFT_48206</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell. Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane.</text>
    </comment>
    <comment type="function">
        <text evidence="20">Catalyzes the exchange of ADP and ATP across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ADP(in) + ATP(out) = ADP(out) + ATP(in)</text>
            <dbReference type="Rhea" id="RHEA:34999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:35000"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="4 20">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="20">Membrane</location>
            <topology evidence="20">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CENP-X/MHF2 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 19">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854438">
        <property type="protein sequence ID" value="KAK4038149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SPD2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005471">
        <property type="term" value="F:ATP:ADP antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140021">
        <property type="term" value="P:mitochondrial ADP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990544">
        <property type="term" value="P:mitochondrial ATP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22921">
        <property type="entry name" value="HFD_CENP-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000001">
        <property type="entry name" value="ADP,ATP carrier protein, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.130.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002113">
        <property type="entry name" value="ADT_euk_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018552">
        <property type="entry name" value="CENP-X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635">
        <property type="entry name" value="ADP,ATP CARRIER PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635:SF14">
        <property type="entry name" value="ADP_ATP TRANSLOCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09415">
        <property type="entry name" value="CENP-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00927">
        <property type="entry name" value="ADPTRNSLCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0050">Antiport</keyword>
    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="14 18 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 18 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 19" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="18">
        <location>
            <begin position="28"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="18">
        <location>
            <begin position="133"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="18">
        <location>
            <begin position="233"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="330"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="347"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="21">
        <location>
            <begin position="364"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00024143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00045250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU368008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAK4038149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="474" mass="51978" checksum="095577E94AF79440" modified="2024-10-02" version="1">MTSKEDIKILGMPTLPRDPAPQLVPTRNTMLTEATVGGVSAAVSKTAAAPIERIKLLVQNQDEMIKAGRLDRRYNGIVDCFRRTTADEGIMALWRGNTANVIRYFPTQALNFAFRDKFKKMFGYKKDRDGYAKWMAGNLASGGAAGATSLLFVYSLDYARTRLANDAKSAKGGGARQFNGLIDVYRKTMATDGIAGLYRGFGPSVAGIVVYRGLYFGMYDSIKPVVLVGSLANNFLASFALGWAVTTGAGIASYPLDTVRRRMMMTSGEAVKYKSSFDAFQQIVAKEGVKSLFKGAGANILRGVAGAGVLSIYDQLQVLMFGKAFKGRGAGRGRGSGMPRGGKRSSKPQEGRKERPGREVVDLGGDDDEDDYTMGEDDLDMDMDRDDRDDREDEDEDKEDEDREKIPGELLTRVLHAFFEREGTRITRDANAAVGRYVDVFVREAIARAAVEREGGFLEVEDLEKIAPQLLMDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SQ00</accession>
    <name>A0AAN6SQ00_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AP complex subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_37720</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854432">
        <property type="protein sequence ID" value="KAK4038332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SQ00"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030117">
        <property type="term" value="C:membrane coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000058">
        <property type="entry name" value="AP complex subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016342">
        <property type="entry name" value="AP_complex_bsu_1_2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002291">
        <property type="entry name" value="AP_complex_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="8">
        <location>
            <begin position="17"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="647"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="716"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="662"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4038332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="756" mass="81809" checksum="458FC770BDEA39A5" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SQ52</accession>
    <name>A0AAN6SQ52_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cyclin-dependent kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_37592</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WHI5/NRM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854428">
        <property type="protein sequence ID" value="KAK4038467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SQ52"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013734">
        <property type="entry name" value="TF_Nrm1/Whi5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08528">
        <property type="entry name" value="Whi5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0678">Repressor</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="194"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="267"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="68"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="152"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="173"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="333"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="347"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="375"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4038467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="447" mass="47660" checksum="4640B9F3D960A58A" modified="2024-10-02" version="1">MNTPTTTTSPVRRRVLGALDPNACSPGKVRRQLEGGKLFSTQPQQSPVKEKAAAAVAFGAPPTPRRMSVAAATSPRRVSSSSPSPSGTPEKETWSKKRGSASPTFIPAPAHATVLGVGARVEEEGEGGEPAAKRACLESAREEEGQTRRAESPPSSTSTTRTTGTTRHRSASPDTPSVFDNSAVDNSQVTILTEPDVTGPAPAPVAAAAPPLPAPRARPTLTREQAREKAEILRLRLGLASYKVRTGQTDVPLDRLEATLAAGARRARGSSFHGHTQQAEAGACQGPTSVSASFPPPGATSTTAGAGRVGNNRRPLPRAPLRRGSSSASVSFEEARSAITRDERRHQNPHYHHHQQQPQQQRHHQNQHQHQHQRRQSEVLDTRGEARRYMYAAENGVPPRPRTATDVADLSSSLRRRASSSFVGYGEEEDLESRGGAASGLLSLARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SQI9</accession>
    <name>A0AAN6SQI9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Bladder cancer-related protein BC10-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_37154</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854416">
        <property type="protein sequence ID" value="KAK4038902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SQI9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009598">
        <property type="entry name" value="BCALP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13259">
        <property type="entry name" value="BLADDER CANCER 10 KD PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13259:SF1">
        <property type="entry name" value="BLADDER CANCER-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06726">
        <property type="entry name" value="BC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01396">
        <property type="entry name" value="BC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4038902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="158" mass="17927" checksum="E0AE9A2238A12B07" modified="2024-10-02" version="1">MFCLRSWLPLLFIPTNASPAFIFLFFLCTYFLNRPCFYCSFLLLILFLTSCNWSDRCFLDLGSNWFQSRPAGSYIYLPIPGWKAAATTNLSAAEDANATASAVVAEMLNTTAGALATAASERITRVRVEWTGLGLEWLRSLLGRREWRIDCLDLYIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SQJ3</accession>
    <name>A0AAN6SQJ3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="17">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">C8A01DRAFT_48012</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-5/BimC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854431">
        <property type="protein sequence ID" value="KAK4038378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SQJ3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008574">
        <property type="term" value="F:plus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000073">
        <property type="term" value="P:initial mitotic spindle pole body separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01364">
        <property type="entry name" value="KISc_BimC_Eg5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000051">
        <property type="entry name" value="Kinesin-like protein bimC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047149">
        <property type="entry name" value="KIF11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047241">
        <property type="entry name" value="KIF11-like_kin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47970:SF12">
        <property type="entry name" value="KINESIN FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47970">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58113">
        <property type="entry name" value="Apolipoprotein A-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="8 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="9 13" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="16">
        <location>
            <begin position="27"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="981"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1058"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1099"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="373"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="424"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="984"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1070"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="1113"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="113"/>
            <end position="120"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAK4038378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1122" mass="124545" checksum="CFD9906362E62514" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SQN8</accession>
    <name>A0AAN6SQN8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_16950</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854412">
        <property type="protein sequence ID" value="KAK4039052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SQN8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF40">
        <property type="entry name" value="TETRACYCLINE-EFFLUX TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="290"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="388"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="433"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="491"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="515"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="549"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="578"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="95"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="459"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="612"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="19"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="459"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="614"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="633"/>
            <end position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4039052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="642" mass="68349" checksum="452057E3A4F22743" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SQR5</accession>
    <name>A0AAN6SQR5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_16435</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854396">
        <property type="protein sequence ID" value="KAK4039619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SQR5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03752">
        <property type="entry name" value="proteasome_alpha_type_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000009">
        <property type="entry name" value="Proteasome subunit alpha type-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003075">
        <property type="entry name" value="PRK03996.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 5 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="7">
        <location>
            <begin position="5"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4039619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="251" mass="27954" checksum="F997915F2E1A000B" modified="2024-10-02" version="1">MSRRYDSRTTIFSPDGRLYQVEYALEAISHAGTAIGILAKDGIVLAAERKVTSKLLEQDTSAEKLYILNDNMICAVAGMTADANILINYARQAAQRYLLTYNEDIPCEQLVRRLCDLKQGYTQHGGLRPFGVSFIYAGWDPQRQFQLYLSNPSGNYGGWKATSSGANHASAQSLLKQDYKEDCTLKEACGMAVKVLSKTMDSTKLSSEKIEFATVGETKDGKIYHKLWSAEEITALLKEHDLAKDETTEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SQY9</accession>
    <name>A0AAN6SQY9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Choline dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_17121</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854418">
        <property type="protein sequence ID" value="KAK4038828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SQY9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF115">
        <property type="entry name" value="DEHYDROGENASE XPTC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042915282" description="Choline dehydrogenase" evidence="3">
        <location>
            <begin position="21"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="4">
        <location>
            <begin position="45"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase C-terminal" evidence="5">
        <location>
            <begin position="485"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="129"/>
            <end position="132"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4038828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="638" mass="67921" checksum="6AE5CD76FB1FF867" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SRF4</accession>
    <name>A0AAN6SRF4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_36606</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854401">
        <property type="protein sequence ID" value="KAK4039396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SRF4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05120">
        <property type="entry name" value="APH_ChoK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF48">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="64"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4039396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="252" mass="28972" checksum="AD6035149CC1D569" modified="2024-10-02" version="1">MASRPTLPYFAPADRLPGPLPTVAEILASKESSVSAAHFAVKYGEPRDGVHLQEGENMLFVQQPSRVPVPTVYAIFHDEGTNKNFIVQEYIPGKLLERVWGGLTSAEKTGIASQLRRHLDELRSIPSPGYYGGIWRQPNLDGYFQDPELDPLPHRDESISKPQETEEQWVDAMWRCVGAKHPNERQNFLSLLRRQYHTIFRGHRPVFTHNDFSPVNIMARDDTKALVIIDWEKSGWYPSFWEYCNAIMLLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SRS1</accession>
    <name>A0AAN6SRS1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thioredoxin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_16409</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854395">
        <property type="protein sequence ID" value="KAK4039638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SRS1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46115">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4039638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="129" mass="13634" checksum="E42F7D2AE8DD9BEA" modified="2024-10-02" version="1">MSDAVNHIASHGDFDSLLATTRYVIVDFYADWCQPCKVIAPHFLKMASTYSIPGFLAFAKVNVDNVGSVAQKYGVAAMPTFMFFKEGKQVAVNGNVTIQGANLPTLTQAAEKMGKLAKEKAAAAAAGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SS04</accession>
    <name>A0AAN6SS04_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pre-mRNA-splicing factor cwf17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_35848</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854383">
        <property type="protein sequence ID" value="KAK4040160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SS04"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052234">
        <property type="entry name" value="U5_snRNP_Component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44006">
        <property type="entry name" value="U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 40 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44006:SF1">
        <property type="entry name" value="U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 40 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="57"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="100"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="142"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="191"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="226"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="318"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4040160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="353" mass="38032" checksum="23D0690545EC66D6" modified="2024-10-02" version="1">MSEKRPAADDPSEGQLVVKRQNVGTSRALTRQAASGSSALIQAGPRTSALQAPLMELSGHTGEIFATKFDPTGNLIASGSMDRTIMLWRIYGDCENYGVLSGHRGAILDLQWSRDGDILFSASADTHLASWDLTSGERIRRYVGHDEIVNAMDVSRRGEELLVSGSDDGTIGIWDPRTKNAADYIETEFPITAVAMSEAGNEIYSGGIDNDIKVWDIRKKGLVHSMLGHTDTVTSLRVSPDGQQLLSYAMDSTARTWDIRPFAPAERHIRTFDGAPLGLEKNLIRGSWDSDGKKIGVGAGDGTVVVWGSDSGKLLYKLPGHKGTVNCAEFAPGDAPIILSASSDRTMLLGELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SS62</accession>
    <name>A0AAN6SS62_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">chitinase</fullName>
            <ecNumber evidence="4">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">C8A01DRAFT_46532</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="4"/>
    <dbReference type="EMBL" id="MU854385">
        <property type="protein sequence ID" value="KAK4040043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SS62"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06548">
        <property type="entry name" value="GH18_chitinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.10:FF:000005">
        <property type="entry name" value="Endochitinase B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000095">
        <property type="entry name" value="Endochitinase B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF384">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042952389" description="chitinase" evidence="14">
        <location>
            <begin position="21"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="15">
        <location>
            <begin position="140"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="51"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="79"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK4040043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="526" mass="56453" checksum="C62BB30314803137" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SSB2</accession>
    <name>A0AAN6SSB2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BAG domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_45533</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854360">
        <property type="protein sequence ID" value="KAK4041284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SSB2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.120">
        <property type="entry name" value="BAG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036533">
        <property type="entry name" value="BAG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003103">
        <property type="entry name" value="BAG_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02179">
        <property type="entry name" value="BAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00264">
        <property type="entry name" value="BAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63491">
        <property type="entry name" value="BAG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51035">
        <property type="entry name" value="BAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="102"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="BAG" evidence="3">
        <location>
            <begin position="297"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="162"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="248"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4041284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="358" mass="39648" checksum="32C5E20B5349202D" modified="2024-10-02" version="1">MPRYGFSNRWAVSPFSSQDGVPDVTSEDYSYITSADLEDHGIDIPRPYAAPSHIDDPYSHSAPSPTFGRQRPEDDVLLIRHQSVTYEEHFPAYSIGDGKLLVSDLRERVKMILDLSDRQARRVKLYYKGRRLKKADSPVREYGAKNNSEILLVPGESGRGSGSETSEEVVVVEADGRDRYETHGNSPRMDSPRMDSPRMDSPRVDSPRVGRSGRWDDRSPRGSGSQVGLGVPVDDNRRRGTSRVRTQSPGSAASAASAPAAAPVGMPGGPIEKLNGIAADFNNNWLPKCLEYIARTPRDSKQRNDEHRKLTESILQQTILKLDAIETSTEEGARARRKALVVEVQNVLSRLDTAKNLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SSD2</accession>
    <name>A0AAN6SSD2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_35194</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854369">
        <property type="protein sequence ID" value="KAK4040822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SSD2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4040822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="397" mass="44544" checksum="F3893053CD190AE0" modified="2024-10-02" version="1">MSSTHSARSSRSSSPEPPDPMIAVAARLKELAHESQAARIAYPADKTEHHRLFCRAVHNVLSTELALFTFAQIVDGLPTLDVAWDRRIPDISVDDHPIEAHAELCPGVMKRTREIRQQLDLSILTFDPVLISAYSKAVLGSQAFQVRLIELVAVTVHQLGALLFNLDVCMHRGGRPDIDRVTQFEEPPLMPGWVEYPRRSPCIADIVGYWAEDRIFGGVAVFDRPAEARGPQQPPNVYFNSPRRVVTFRYTQLLDEQQQSMVDFFLSENSSEENCPLPVLTDKRNRVRVDFDKAIMHRMIHRDAWECMPPSEEALRLHNKRPQNEFDYPEHRDLLEAVNRQLGIPPPKRHGGAQNGGEIQSIGAQGSVPQDKSRGFTPGDRESQGSGDPTVGDGKDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SSH3</accession>
    <name>A0AAN6SSH3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxymethylenebutenolidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_15497</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854372">
        <property type="protein sequence ID" value="KAK4040685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SSH3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030638">
        <property type="term" value="P:polyketide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009959">
        <property type="entry name" value="Cyclase_SnoaL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38436:SF3">
        <property type="entry name" value="CARBOXYMETHYLENEBUTENOLIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38436">
        <property type="entry name" value="POLYKETIDE CYCLASE SNOAL-LIKE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4040685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="416" mass="45412" checksum="D87493CA8F28FBA5" modified="2024-10-02" version="1">MDINAPTAQRPSAPCVQVTPEISIQPPLSRRGNGPGLVLVVSAALDLSRHDKTLDPPPLQKWAEEGYAVAQILVSGESNVADHLRTATAELEKLPECSGDKMGLVAMLDESTPDHQPLLDAIRAHQKIVTSVFYGSCPDGELGVPVLAHLPSNTKAPRAGGGEGARGLTAHTYPAAARFFAIPAHADYRASAAAVAHTRSLAFLKPLMGGPYFDLEAIWEEHTRYEFADRSVGETMATMVDEPYVNHVPTLTGGIGRAKLTAFYRDHFIFSNPADAALELVSRTVGIDRVVDEFLFNCTHDRVIDWLIPGIPPTFKPLSIPFTGIVNIRGDRLYHEHIAWDQGTVLRQLGLLPEYLPFPHALPGGREPAERKQFEYRVPVAGGETARKLLDESAAPSNEMFAFAVREVARKDQVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SSY2</accession>
    <name>A0AAN6SSY2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">laccase</fullName>
            <ecNumber evidence="4">1.10.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">C8A01DRAFT_15121</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4 hydroquinone + O2 = 4 benzosemiquinone + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11276"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17594"/>
            <dbReference type="ChEBI" id="CHEBI:17977"/>
            <dbReference type="EC" id="1.10.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.10.3.2" evidence="4"/>
    <dbReference type="EMBL" id="MU854363">
        <property type="protein sequence ID" value="KAK4041135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SSY2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052716">
        <property type="term" value="F:hydroquinone:oxygen oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046274">
        <property type="term" value="P:lignin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13880">
        <property type="entry name" value="CuRO_2_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13901">
        <property type="entry name" value="CuRO_3_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000045">
        <property type="entry name" value="Laccase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000046">
        <property type="entry name" value="Multicopper oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF87">
        <property type="entry name" value="LACCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0186">Copper</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0439">Lignin degradation</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042865466" description="laccase" evidence="10">
        <location>
            <begin position="25"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="13">
        <location>
            <begin position="84"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="11">
        <location>
            <begin position="192"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="12">
        <location>
            <begin position="414"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK4041135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="590" mass="65251" checksum="DE6AD021895449F7" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6STT5</accession>
    <name>A0AAN6STT5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PD-(D/E)XK nuclease-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_33671</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854343">
        <property type="protein sequence ID" value="KAK4042322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6STT5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046797">
        <property type="entry name" value="PDDEXK_12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20516">
        <property type="entry name" value="PDDEXK_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PD-(D/E)XK nuclease-like" evidence="2">
        <location>
            <begin position="197"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4042322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="452" mass="49499" checksum="2295BD270F82FDEC" modified="2024-10-02" version="1">MATPPPSSSFQTRRSPSPSKKRKIDQDGDQDDGGSQDAGATPRSGPPSQRPALSIRPASFHPPSSTGLGHSSAPSLASDRQSSRRSASPVKTITGLQRLDKPVLYRSLDGGKLYRDVLAVTTYRTGIYPAEIRPQIESLFDDLAPPDSVYRKPEEGTRRPDRGRLAQDAGKEEDKEGEEEEGPFFDYLPLSSLFADRPEAASPLARFALAEFYKIRAIERVARECLDLRRSEAAWNAHVHGPLLELALSRRRGSVVYENATSARILPCFRPSLVTGEVSEGKMNRLIELSTRARSTALASAQLNVNQTDYTPLTRSPSAVSIETKVAGASLEEGRLQLGIWTAAWHKRMEMLGVGGGMHGPQLPTLPLILVHDHQWSLYFAVDRLERIEVCGALLIGMTDSFPNIYQLLTVLGLLGTWVDTTFCSWTTGAFGPHPDVIADADVRSDELVTQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6STV5</accession>
    <name>A0AAN6STV5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex</fullName>
            <ecNumber evidence="10">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">C8A01DRAFT_14264</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + 2-methylpropanoyl-CoA = N(6)-[(R)-S(8)-2-methylpropanoyldihydrolipoyl]-L-lysyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:18865"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:10497"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57338"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83142"/>
            <dbReference type="EC" id="2.3.1.168"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:18866"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="10"/>
    <dbReference type="EMBL" id="MU854346">
        <property type="protein sequence ID" value="KAK4042095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6STV5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043754">
        <property type="term" value="F:dihydrolipoamide branched chain acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031405">
        <property type="term" value="F:lipoic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045333">
        <property type="term" value="P:cellular respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000013">
        <property type="entry name" value="Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000007">
        <property type="entry name" value="Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.320.10:FF:000002">
        <property type="entry name" value="Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="entry name" value="E3-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050743">
        <property type="entry name" value="2-oxoacid_DH_E2_comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43178">
        <property type="entry name" value="DIHYDROLIPOAMIDE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43178:SF5">
        <property type="entry name" value="LIPOAMIDE ACYLTRANSFERASE COMPONENT OF BRANCHED-CHAIN ALPHA-KETO ACID DEHYDROGENASE COMPLEX, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 14" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 10" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="12">
        <location>
            <begin position="14"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="13">
        <location>
            <begin position="154"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="96"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="193"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK4042095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="473" mass="51098" checksum="83417D3CB7F78853" modified="2024-10-02" version="1">MARAFHAARPLLAVKPVLLADIGEGIVECEIIQWFVEPGARVEEFSPLCEVQSDKASVEITSRFAGVVKKLRYDAGEMAKVGKPFVDIDIQGDAKEEDVGTMVPPETPRTEAEPKPTQAPVRPPAEETAAAQVAVLTEHETEHTPKVKGKHAALATPAVRHLSKELKVDISEIDGTGRDGRVLKEDIYKFVERRNAAPTQPPSTQPTPGTHPTGAFTPPEVPTAGPQQETPIALTRTQEMMFKTMTRSLSIPHFLYADEVDFTSLVELRGRLNKVLSKSGLSDSQVGKLSYLPFIIKAVSMSLYKYPTLNARVDVDSSSKPTLVLRSQHNIGVAMDTPSGLLVPVIKNVGGLNILGIAAELARLQALAVAGKLSPHDMAGGTITVSNIGNIGGTYLSPVVVEREVAILGIGRMRTVPAFSSVPGEEDRVVRRQVCNFSWSADHRVVDGATMARAAEVVRAIVEEPDVMVMHLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SUA0</accession>
    <name>A0AAN6SUA0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_32480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854328">
        <property type="protein sequence ID" value="KAK4043354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SUA0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="467"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="291"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4043354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="489" mass="52830" checksum="746A5B8E30F357D7" modified="2024-10-02" version="1">MPWAGIEVEQLGDATEEGESPTSRSPSEEGGLEGDVDEVVDEMQEDDDDGDAEQPSLKRRRIENPQLDIGNQSGRGHQVQENVAQQHHVNGNGNGQGYMQEQVPAVPGDDKVPFFKSPLADLDDKGENDCFFDSCVTRAGGNQYLMKHFRDKHGLIRGDQGRQEGGKRKAPKYLTLCPTNWPFTYNSSSSCHACGDISGLFAVLGQREHESPAICSFCWTYLPTRRDLVTHIDEGPCKSNEMFAGKLTLVRHMYAGTLRIPGADEISRAAAEQRQAHADAERAARSEKWQLEQQMQQQAQEHLRQLQAQQSQQQQQQQSQPQPRTPIHPEYHHPPPQQAPPPATQPPFSIHRFTPTAPPPILPPTPSPAPENPVPHTSAPPPPGTPHTGAGAGTVVSAAGVGAVGGVDYAVPAATAEAMARSIERLSGIVGDLTAANALLLQEVRVRDRRIEELGRERERLVGEVGRLGGKVGGSVGGGDGGVREGGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SUF7</accession>
    <name>A0AAN6SUF7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-galactosidase</fullName>
            <ecNumber evidence="3">3.2.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">C8A01DRAFT_44500</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyl hydrolase 35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="3"/>
    <dbReference type="EMBL" id="MU854340">
        <property type="protein sequence ID" value="KAK4042488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SUF7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000040">
        <property type="entry name" value="Beta-galactosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.20.10">
        <property type="entry name" value="Beta-galactosidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018954">
        <property type="entry name" value="Betagal_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037110">
        <property type="entry name" value="Betagal_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025972">
        <property type="entry name" value="BetaGal_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036833">
        <property type="entry name" value="BetaGal_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025300">
        <property type="entry name" value="BetaGal_jelly_roll_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031330">
        <property type="entry name" value="Gly_Hdrlase_35_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001944">
        <property type="entry name" value="Glycoside_Hdrlase_35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23421">
        <property type="entry name" value="BETA-GALACTOSIDASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13364">
        <property type="entry name" value="BetaGal_ABD2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10435">
        <property type="entry name" value="BetaGal_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13363">
        <property type="entry name" value="BetaGal_dom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01301">
        <property type="entry name" value="Glyco_hydro_35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00742">
        <property type="entry name" value="GLHYDRLASE35"/>
    </dbReference>
    <dbReference type="SMART" id="SM01029">
        <property type="entry name" value="BetaGal_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117100">
        <property type="entry name" value="Beta-galactosidase LacA, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042862648" description="beta-galactosidase" evidence="10">
        <location>
            <begin position="22"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-galactosidase" evidence="11">
        <location>
            <begin position="410"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="24"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK4042488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1030" mass="112901" checksum="B731B513791B44C4" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SUF8</accession>
    <name>A0AAN6SUF8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA topoisomerase I</fullName>
            <ecNumber evidence="7">5.6.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">DNA topoisomerase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">C8A01DRAFT_13861</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6 7">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6 7">Belongs to the type IB topoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="7"/>
    <dbReference type="EMBL" id="MU854339">
        <property type="protein sequence ID" value="KAK4042546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SUF8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00659">
        <property type="entry name" value="Topo_IB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03488">
        <property type="entry name" value="Topoisomer_IB_N_htopoI_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.41:FF:000001">
        <property type="entry name" value="DNA topoisomerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.10:FF:000003">
        <property type="entry name" value="DNA topoisomerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.11.10:FF:000001">
        <property type="entry name" value="DNA topoisomerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.15.10:FF:000002">
        <property type="entry name" value="DNA topoisomerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.11.10">
        <property type="entry name" value="DNA Topoisomerase I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.15.10">
        <property type="entry name" value="Topoisomerase I, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.41">
        <property type="entry name" value="Yeast DNA topoisomerase - domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013034">
        <property type="entry name" value="DNA_topo_DNA_db_N_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013030">
        <property type="entry name" value="DNA_topo_DNA_db_N_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001631">
        <property type="entry name" value="TopoI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025834">
        <property type="entry name" value="TopoI_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014711">
        <property type="entry name" value="TopoI_cat_a-hlx-sub_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014727">
        <property type="entry name" value="TopoI_cat_a/b-sub_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013500">
        <property type="entry name" value="TopoI_cat_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008336">
        <property type="entry name" value="TopoI_DNA-bd_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036202">
        <property type="entry name" value="TopoI_DNA-bd_euk_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013499">
        <property type="entry name" value="TopoI_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048045">
        <property type="entry name" value="Topoisomer_I_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051062">
        <property type="entry name" value="Topoisomerase_IB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10290:SF3">
        <property type="entry name" value="DNA TOPOISOMERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10290">
        <property type="entry name" value="DNA TOPOISOMERASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14370">
        <property type="entry name" value="Topo_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01028">
        <property type="entry name" value="Topoisom_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02919">
        <property type="entry name" value="Topoisom_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00416">
        <property type="entry name" value="EUTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00435">
        <property type="entry name" value="TOPEUc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56741">
        <property type="entry name" value="Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52038">
        <property type="entry name" value="TOPO_IB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="DNA topoisomerase I eukaryotic-type" evidence="10">
        <location>
            <begin position="426"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="771"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="224"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="active site" description="O-(3'-phospho-DNA)-tyrosine intermediate" evidence="6">
        <location>
            <position position="872"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK4042546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="916" mass="103331" checksum="2279A17BD529EF47" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SUL2</accession>
    <name>A0AAN6SUL2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Vacuolar calcium ion transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">C8A01DRAFT_32805</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Has a role in promoting intracellular calcium ion sequestration via the exchange of calcium ions for hydrogen ions across the vacuolar membrane. Involved also in manganese ion homeostasis via its uptake into the vacuole.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Vacuole membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854331">
        <property type="protein sequence ID" value="KAK4043162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SUL2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000011">
        <property type="entry name" value="Vacuolar calcium ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004798">
        <property type="entry name" value="CAX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00846">
        <property type="entry name" value="caca2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00378">
        <property type="entry name" value="cax"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF22">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0050">Antiport</keyword>
    <keyword evidence="6 10" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 10" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="8 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <keyword evidence="10" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="239"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="363"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="392"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="429"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="453"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="12">
        <location>
            <begin position="133"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="12">
        <location>
            <begin position="330"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK4043162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="481" mass="51556" checksum="F51800985D1C1A34" modified="2024-10-02" version="1">MENGLDSSHLTRPTVNLKTRDQIRRETGKFPSPPNGNGGSSAHFSSLDEMDGERRPLLGHQTASNLHAEPGFWRHLLVNNQSSPGTDSPNPFVRWPARVWNVTKITLFSSWINLLLVFVPLGIVAGEREWGAPWVFTLNFLAIIPLAAVLSFATEEIAGRLGETLGGLVNATFGNAVELIVSIVALRAGEIEVVQASMLGSILSNLLLVLGMCFFLGGVYNMRGPDGHGTEQSFSTATAQTTCSLMTLASASMILPAALYGVLSKADEDNKQASILVLSRGTAIILLFLYVLYLYFALRTHKKLFEPEAQANGSGEEEHEPLLGPWSAGLVLVVVTLIISVCADYMVDSIDALVATGKISKTFIGLILIPIVGNAAEHVTACVVAVKDKMDLAMGVAIGSSIQIALLVTPALVMLGWAIGQPMTLHFETFETIAFALSVLVVTYTVQDGKSNYLEGAMLLGLYMIIALAFWASPTDALGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SV57</accession>
    <name>A0AAN6SV57_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pre-mRNA-splicing factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_13151</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in mRNA splicing where it associates with cdc5 and the other cwf proteins as part of the spliceosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Belongs to the 40S cdc5-associated complex (or cwf complex), a spliceosome sub-complex reminiscent of a late-stage spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWF11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854329">
        <property type="protein sequence ID" value="KAK4043281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd17935">
        <property type="entry name" value="EEXXQc_AQR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000507">
        <property type="entry name" value="Pre-mRNA-splicing factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048966">
        <property type="entry name" value="Aquarius_b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048967">
        <property type="entry name" value="Aquarius_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032174">
        <property type="entry name" value="Aquarius_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026300">
        <property type="entry name" value="CWF11_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF5">
        <property type="entry name" value="RNA HELICASE AQUARIUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16399">
        <property type="entry name" value="Aquarius_N_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21143">
        <property type="entry name" value="Aquarius_N_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21144">
        <property type="entry name" value="Aquarius_N_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038901">
        <property type="entry name" value="AQR_cwf11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="2" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA helicase aquarius N-terminal" evidence="6">
        <location>
            <begin position="34"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="RNA helicase aquarius beta-barrel" evidence="7">
        <location>
            <begin position="504"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="domain" description="RNA helicase aquarius insertion" evidence="8">
        <location>
            <begin position="715"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="4">
        <location>
            <begin position="819"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="5">
        <location>
            <begin position="1126"/>
            <end position="1318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1429"/>
            <end position="1458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR038901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF21143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF21144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4043281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1458" mass="163002" checksum="48F7D69696543AFE" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SVE5</accession>
    <name>A0AAN6SVE5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ornithine decarboxylase</fullName>
            <ecNumber evidence="10">4.1.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">C8A01DRAFT_43618</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-ornithine + H(+) = putrescine + CO2</text>
            <dbReference type="Rhea" id="RHEA:22964"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:326268"/>
            <dbReference type="EC" id="4.1.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="9">Amine and polyamine biosynthesis; putrescine biosynthesis via L-ornithine pathway; putrescine from L-ornithine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Homodimer. Only the dimer is catalytically active, as the active sites are constructed of residues from both monomers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Orn/Lys/Arg decarboxylase class-II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.17" evidence="10"/>
    <dbReference type="EMBL" id="MU854327">
        <property type="protein sequence ID" value="KAK4043493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SVE5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004586">
        <property type="term" value="F:ornithine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033387">
        <property type="term" value="P:putrescine biosynthetic process from arginine, via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00622">
        <property type="entry name" value="PLPDE_III_ODC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.37.10:FF:000010">
        <property type="entry name" value="Ornithine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.10:FF:000005">
        <property type="entry name" value="Ornithine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="entry name" value="Lyase, Ornithine Decarboxylase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022657">
        <property type="entry name" value="De-COase2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022653">
        <property type="entry name" value="De-COase2_pyr-phos_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002433">
        <property type="entry name" value="Orn_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11482">
        <property type="entry name" value="ARGININE/DIAMINOPIMELATE/ORNITHINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11482:SF6">
        <property type="entry name" value="ORNITHINE DECARBOXYLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01182">
        <property type="entry name" value="ORNDCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="Alanine racemase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00878">
        <property type="entry name" value="ODR_DC_2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00879">
        <property type="entry name" value="ODR_DC_2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="6 15" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn/DAP/Arg decarboxylase 2 N-terminal" evidence="16">
        <location>
            <begin position="86"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="15">
        <location>
            <position position="399"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="15">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00039485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR600183-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAK4043493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="462" mass="50971" checksum="FB7E3EAEE3921926" modified="2024-10-02" version="1">MVMPTLVTDRFTSLDYTDFTNNHVFLKSCNNGFFDYNQHGHHDHHDGRKLNSAKQLIGDALRERVENIDHEFCEPGEEDTFFVADLGEVYRQHLRWKLNLPRVKPFYAVKCNPDPKLLGLLSALGTGFDCASKAEIEQVLGLGVDPSRIIYAQPCKTNSYVRYVANQGVRQMTFDNADELRKIARLYPGAELFLRILTDDSSSLCRLSLKFGASLDSTDSLLALARELGLNVVGVSFHVGSGASDPGAFLKAVQDAHVVFQQAASHGFSLKTLDVGGGFCSDNTFEQMAGVLRGALDDYFPAHSGINLIAEPGRYYASAAFTLACNVIARRTIEDMSAASYMVYVNDGLYGNFSSIMFDHQHPVAKVLRSGGRTMYNMPAGEATDGADGIEYSIWGPTCDGIDRITESIRFPQLLDVGDWLYFEDMGAYTKCSATTFNGFTNSHDTIYVCSEPGARALLDLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SVK5</accession>
    <name>A0AAN6SVK5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_43314</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854324">
        <property type="protein sequence ID" value="KAK4043746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SVK5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4043746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="373" mass="42454" checksum="98CBC9E0CB227F3E" modified="2024-10-02" version="1">MALCVALPVDPAPDEYQEGRPLDLQVCKSYSPNLPSRVTATISKVLSMTMSVVLDVTLQTRHGPPVHRVLKLYDRRFGSCLREVDGDRVAPHTQENEAAFEAFVRRGMMPGFLRHRHERNDPEESVLPVGAREFLDEPNRTEGLAKYEAALWQDCSEHFECETKAYHRLAKLQGTVVPRLYAHVSLLSTTKLATIMPPEVAPYFEVRGILLERIDGYCLDNLTLGPLPKNLRTWQHIIQLAADAAYEINKHGIIMEDCAPRNVVVDGKSQTPRIVDLAQCMFRDEMVSEWYKSGWHEDEDWDPELEYWEQVSTTCNPGAIAAVIANRIHRKTGAKLEFRYPDWNGIIAEIRRRKEDAAAVERKTRHKASTAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SVT9</accession>
    <name>A0AAN6SVT9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_31874</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854322">
        <property type="protein sequence ID" value="KAK4044001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SVT9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043046214" evidence="1">
        <location>
            <begin position="17"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4044001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="161" mass="15063" checksum="298086D75E1C6A14" modified="2024-10-02" version="1">MRYAAIIAAFAALASAQTTTTTTTTATTTSSSSLDTSSLSSISSALSSISSALSSISSAASSQVSSITSNAGSVAASLSSQLSTATDSALRSSITSQLGGLTSSASSASSASSASSASSAVSSANTAAESKTSSTENAGPVQTAAVGMGALLGGAAVLVNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SWF3</accession>
    <name>A0AAN6SWF3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribonuclease H-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_42513</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CAF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854317">
        <property type="protein sequence ID" value="KAK4044601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SWF3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990431">
        <property type="term" value="P:priRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990432">
        <property type="term" value="P:siRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051181">
        <property type="entry name" value="CAF1_poly(A)_ribonucleases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006941">
        <property type="entry name" value="RNase_CAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15092">
        <property type="entry name" value="POLY A -SPECIFIC RIBONUCLEASE/TARGET OF EGR1, MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15092:SF22">
        <property type="entry name" value="POLY(A)-SPECIFIC RIBONUCLEASE PNLDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04857">
        <property type="entry name" value="CAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="429"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="429"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4044601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="516" mass="57610" checksum="57416512D6F4613F" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P439</accession>
    <name>A0AAN6P439_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fungal N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_21382</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854832">
        <property type="protein sequence ID" value="KAK4031384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P439"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="255"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4031384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="343" mass="37710" checksum="3FAB553A9DACB8B2" modified="2024-10-02" version="1">MDPLSITAGCIGIIGAIAKTSTTIRGFVRDVRDARGELGATARHLAELDMTINLIKDDHNQSAEDSDRHIPESITAQTTTVIKSCHDILAELDALIDKHNPRRHQTPLRWVLKGKDEVSALNRQLEAHTRTLTMALEISTLSDTAALGVVSGQIKDNTTQLRKDTEQILSEMHRLRSRFGLQQLDDPPSQGRIDIIERYLDSLTNYAETVVGSFDGDGHGSLPRTSVAMDSSDDEDNKSLRTADRGQGTGHVRTPSHQSSPTPTPSQEAEVELNSGGESHATAPDSRPSDPSRPHVLDSAKMRFRQSAARHFGETVRARFPSLLLRRRVPAMDAGPFLQVRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P496</accession>
    <name>A0AAN6P496_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldehyde/histidinol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_42092</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854801">
        <property type="protein sequence ID" value="KAK4031458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P496"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43111">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43111:SF1">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="447"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="2">
        <location>
            <begin position="17"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4031458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="483" mass="52912" checksum="6B1A658A4CD89504" modified="2024-10-02" version="1">MSKRFSNISSAAIDGRALNPIFRKTQLKQLHDALSDKASEIQDAIRNDTGHTPAEVQIEYWLAMRQLTQAYTAIDTDRAFHDEYAVSRGQSASQAREAAGIVVIHPTRHAFFACLMSALVPALAAGNCVIVQAEQSLLRTPRLVLDVIARALDHDIFETTTAPVNESDLGHPHIRVLQNGSDGAHLSHHLVSDPEARVVAVVERDADLDVAAQELVRARFALRGRSPYPPDVVLVNEWVKREFLEAVVRHTVRFVAEDGKKTPPLTAPGQSLSELVRTEKGVNVLSWSSAGAVVEVEDRKSLLLRRKVQESCLLVHAVTSIDDAIDFSTSNTRLGAAYVFTKPSAAKYICQFLDTPMSFVNHVPTSLLFLPMAPLNTSVDPQTYSPYNEAAFCRPKGQFVAPAAQENVLAQLLQQASPQQLNTIGQQALTKLPVVKRVRRGIEHIGFFNHGVLTGGVLLLSTVLGVTGVCSYYAFGFVRGRVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P5H0</accession>
    <name>A0AAN6P5H0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Sugar transporter-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">C8A01DRAFT_41417</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854644">
        <property type="protein sequence ID" value="KAK4032133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P5H0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000023">
        <property type="term" value="P:maltose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000149">
        <property type="entry name" value="MFS transporter, SP family, general alpha glucoside:H+ symporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF5">
        <property type="entry name" value="ALPHA-GLUCOSIDES PERMEASE MPH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0462">Maltose metabolism</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="51"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="312"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="350"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="374"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="402"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="448"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="477"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="54"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK4032133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="556" mass="62195" checksum="E43CFCB764A5AABF" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P5L7</accession>
    <name>A0AAN6P5L7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Very low-density lipoprotein receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_20693</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854635">
        <property type="protein sequence ID" value="KAK4032209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P5L7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043051551" evidence="7">
        <location>
            <begin position="19"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="132"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4032209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="278" mass="29258" checksum="424BDA118662006C" modified="2024-10-02" version="1">MRLLQTLAGLLLSPHALAAIEFVNPPLPGAKKDFVKNPVYEVGSVVEIVWTPAPDGVPVTLALLQEDIGTKITSDWERIAEKTVDTTRFKWIVATKYDLAVSPVFYILLFEDEKTGPSANCHYFNITQPEASTRSSTSTTSSTSTTSSMSTTSSTSTTSSTNTTNTSSGPAASSNSDPGTTSSSSSGLSTAAAIGIGVAIPCALIIGAVAAWFLFRRRKQQPGLPPAAPIYEVGSSPHSGMSEQWGGGSTPMAAVKYAPVELDESKKVAELPTANYNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P6L5</accession>
    <name>A0AAN6P6L5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DDHD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_20345</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854593">
        <property type="protein sequence ID" value="KAK4032590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P6L5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004177">
        <property type="entry name" value="DDHD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058055">
        <property type="entry name" value="PA-PLA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055555">
        <property type="entry name" value="PA-PLA1_DUF7131"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057826">
        <property type="entry name" value="WWE_C20G8.02"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23509:SF10">
        <property type="entry name" value="LD21067P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23509">
        <property type="entry name" value="PA-PL1 PHOSPHOLIPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02862">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23465">
        <property type="entry name" value="DUF7131"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23463">
        <property type="entry name" value="WWE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01127">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51043">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDHD" evidence="2">
        <location>
            <begin position="652"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="820"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="823"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="868"/>
            <end position="878"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4032590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1014" mass="112470" checksum="F26D524905725DF4" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P6S4</accession>
    <name>A0AAN6P6S4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_50577</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854584">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P6S4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="PH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057081">
        <property type="entry name" value="PH_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23076">
        <property type="entry name" value="PH_FT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23074">
        <property type="entry name" value="PH_FT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="1">
        <location>
            <begin position="235"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="355"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4032680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="484" mass="56050" checksum="16EF11A8BB420D76" modified="2024-10-02" version="1">MEQPGPANVPVETHLLLGCCREADQADVVARGLDQLRAALSESFHGHLIALAEEIRDSSRLLRGLADRSQMHITRVPFMTNYLNVVLPCLSRTLKDITAYYEDKTLSREIRWRKMYNKMTEEAGGLPLPQRFVLYNHFLSLLKQLLTRSPSFDLNTLETLRTRIITLREQRGIPPPTTQAGALVRQNLMSLAVVQDRNSHWAEQIFSLPLPSRTALKHLRSSKSYGPFYPWGHLTIPQDSTVLFRRPFDNDTISIVVFLSSVDQCPYFLMRTVQNNTPWYSMFGAHELCIEREGSALQLKRWSRSEQCSKLWVALYFLTWEEMALFYCTFVALKARNLLTVQIHPNEFQLGREKRLFQAQIVDDGFKHSLIVYEDMQTRGLRLHAAVWEGELRQCPVWTAFVTHQSQSPTWLSRRSRHRVWLKDIQLYVFCNTYRQENMRQNKSGAFEIYFDREEAAKRFKELFSARSAALETSENAPVAGPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P760</accession>
    <name>A0AAN6P760_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_20813</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854654">
        <property type="protein sequence ID" value="KAK4032077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P760"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021709">
        <property type="entry name" value="DUF3292"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38694">
        <property type="entry name" value="CONSERVED EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38694:SF1">
        <property type="entry name" value="PEROXIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11696">
        <property type="entry name" value="DUF3292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4032077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="203" mass="21747" checksum="6C900CE63BB9BF97" modified="2024-10-02" version="1" fragment="single">IAHDPSTAAQTGGSDIDAAKDAKHGRKGSKILGFFKGTTRGVVKTAVGTDTVRAKAGSQPARNRLGVIPAARDTAPVSGPVEFEARWEGQKGRVYISTSGATVPVVAFGKGERMGTVRIAGEERQDLQAVWSVPVADVVEMRKIGGYGWKAKLVVGWSMEREVKDGLVIRTVDGGEYKITAVPLRDELFNRLVAMGGQKWEAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P7D2</accession>
    <name>A0AAN6P7D2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Oligosaccharyltransferase 48 kDa subunit beta-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_50970</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854638">
        <property type="protein sequence ID" value="KAK4032182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06071">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01201">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1540.10">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056252">
        <property type="entry name" value="Alfy-like_Arm-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000409">
        <property type="entry name" value="BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051944">
        <property type="entry name" value="BEACH_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055459">
        <property type="entry name" value="OST48_MD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055457">
        <property type="entry name" value="OST48_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023362">
        <property type="entry name" value="PH-BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46108">
        <property type="entry name" value="BLUE CHEESE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46108:SF4">
        <property type="entry name" value="BLUE CHEESE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23295">
        <property type="entry name" value="Arm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02138">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13385">
        <property type="entry name" value="Laminin_G_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23358">
        <property type="entry name" value="OST48_MD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03345">
        <property type="entry name" value="OST48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14844">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01026">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81837">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50197">
        <property type="entry name" value="BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51783">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="2832"/>
            <end position="2855"/>
        </location>
    </feature>
    <feature type="domain" description="BEACH-type PH" evidence="7">
        <location>
            <begin position="1673"/>
            <end position="1806"/>
        </location>
    </feature>
    <feature type="domain" description="BEACH" evidence="6">
        <location>
            <begin position="1845"/>
            <end position="2126"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="2260"/>
            <end position="2301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="758"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="973"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1563"/>
            <end position="1663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="987"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1566"/>
            <end position="1587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1593"/>
            <end position="1609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1642"/>
            <end position="1661"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4032182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="2869" mass="321026" checksum="D200904351FE106F" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P7P1</accession>
    <name>A0AAN6P7P1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_50912</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854629">
        <property type="protein sequence ID" value="KAK4032270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P7P1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4032270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="359" mass="40444" checksum="A763C79CEBA027F9" modified="2024-10-02" version="1">MAHLPRLALTLPPTGAARGVLHPGRRPRAAFRALPAPLPTDIVLYLHREHLPPATAVALSLTCKALFGLVFPTAAPGFSRDPLERQALQLLLERDLGQHWWYCHGCSLLHRIRSQGPTGGVHDSSSRRVIIWNPRRPHHNSHFLDGSSFVLDYESVRLVMNRHFLGSPNGLPLESFDVEASSTVFNPWQGRLLPWRERWSARILQDELFLSATSTLSSAGWADETFRAALDHEWRQVCGHVRTSSALPYHTVTALRHPSREYAGFFAPCRDFVEACGQCLTDYATTVERRRGDAKQPTESWFITVTSYYQLGSGRSPTDAKWEAFGHRTTVSSYFTKRDFVAHPPGAVKAVWDSYKPWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P7S4</accession>
    <name>A0AAN6P7S4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF6594 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_20585</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854622">
        <property type="protein sequence ID" value="KAK4032330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P7S4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046529">
        <property type="entry name" value="DUF6594"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34502:SF6">
        <property type="entry name" value="DUF6594 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34502">
        <property type="entry name" value="DUF6594 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20237">
        <property type="entry name" value="DUF6594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="515"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="553"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6594" evidence="4">
        <location>
            <begin position="257"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="323"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="92"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="431"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="46"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="92"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="440"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4032330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="577" mass="62916" checksum="294CC246DAE03425" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P7X0</accession>
    <name>A0AAN6P7X0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NACHT-NTPase and P-loop NTPases N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_21391</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854840">
        <property type="protein sequence ID" value="KAK4031371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P7X0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031352">
        <property type="entry name" value="SesA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17107">
        <property type="entry name" value="SesA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NACHT-NTPase and P-loop NTPases N-terminal" evidence="2">
        <location>
            <begin position="78"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4031371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="256" mass="28246" checksum="328DE700D3963BBF" modified="2024-10-02" version="1">MVQIAAGANRCRGAIFYPKKVTNVNPFTVLDDEDSNHTHIQSHNRCLSAGSLKKRIPFVCSCSLPPLILAYQSLSTDMLPLVEQTLREAKAPAKKVKSTDDSNMLGTRLDNCEEKADDLLEIFQKIARKSTQEYVPSVYRSIAVKLGKYRAETLMGGMVEDLLALVAHHVFQAVMQKQVEPLEKARHELANVSPSLSESDLDEQAGTASQHGDGNRQFNNFGTGTQKNVDGSYFEAKGDQNFGMVPPKESMGKKET</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P800</accession>
    <name>A0AAN6P800_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein bem46</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_40087</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854529">
        <property type="protein sequence ID" value="KAK4033454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P800"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF64">
        <property type="entry name" value="SUPERFAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01760)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4033454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="417" mass="45898" checksum="AD506CE88A62659C" modified="2024-10-02" version="1">MIAHRRMPRPCVQRSPVQLRCLLHTGRGSTRLPSAHFWASVKHDRTLGATHAQAVFAGRSCRDIHIPTILLPPVVFTGLLVGLWIWKCLMMVVFQNKIIYMPGLPPTSRRERIADWASMCGGIQWTEERTVAADGTKLALAVTTVPLPKGRQSAAAAPDEPAAAHVYVLYFQGNASSIPPRLPDLSWVLRAVSDSKTHAPMAPMQLTFVCLSYRGYWTSRGRPSEPGLRLDAEAGVRWIAERHERVFGNAGTSGRTTDPILLVWGQSIGSGVATNLAATGRAPSSMPIRGLLLETPFVSIRAMLETLYPQKWLPYKYLWPFLRNHLDSWGNLGLIAQASKEKGGAAPMVYILEAERDEIVPKEQSERLYQRCVGLGLPAEKGTVPVAYHQEAIARGDGKKLAAQAILKLIQRARDGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P834</accession>
    <name>A0AAN6P834_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cupredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_49921</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854526">
        <property type="protein sequence ID" value="KAK4033499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P834"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13854">
        <property type="entry name" value="CuRO_1_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13880">
        <property type="entry name" value="CuRO_2_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13901">
        <property type="entry name" value="CuRO_3_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000021">
        <property type="entry name" value="Extracellular dihydrogeodin oxidase/laccase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000038">
        <property type="entry name" value="Extracellular dihydrogeodin oxidase/laccase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF145">
        <property type="entry name" value="LCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Plastocyanin-like" evidence="9">
        <location>
            <begin position="87"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="7">
        <location>
            <begin position="214"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="8">
        <location>
            <begin position="446"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4033499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="595" mass="65749" checksum="8BF783E881C41982" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P8A9</accession>
    <name>A0AAN6P8A9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ankyrin repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_49845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854520">
        <property type="protein sequence ID" value="KAK4033601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P8A9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42024">
        <property type="entry name" value="AMINO ACID PERMEASE_ SLC12A DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42024:SF1">
        <property type="entry name" value="AMINO ACID PERMEASE_ SLC12A DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4033601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="616" mass="67902" checksum="D6ACE871F5F411B4" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P8N8</accession>
    <name>A0AAN6P8N8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amino-acid permease BAT1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_39816</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854513">
        <property type="protein sequence ID" value="KAK4033730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P8N8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF26">
        <property type="entry name" value="OS04G0435100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="277"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="385"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="413"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="452"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="479"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="525"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="529"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4033730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="548" mass="58734" checksum="7664DE7825B248BF" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P929</accession>
    <name>A0AAN6P929_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_21120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854721">
        <property type="protein sequence ID" value="KAK4031712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P929"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19481">
        <property type="entry name" value="RecA-like_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054289">
        <property type="entry name" value="DUF7025"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411:SF2">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411">
        <property type="entry name" value="FAMILY ATPASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22942">
        <property type="entry name" value="DUF7025"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="2">
        <location>
            <begin position="497"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4031712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="711" mass="79642" checksum="8D1F6C5EBBCB1D69" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P938</accession>
    <name>A0AAN6P938_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_20326</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854591">
        <property type="protein sequence ID" value="KAK4032603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P938"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4032603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="450" mass="49232" checksum="A6FA74B1650CC3BD" modified="2024-10-02" version="1">MLPPSPPSTLYSPPHPSQTTLPEITRSTCLSYAQTRFPHATIREAPHQGRCSYTLFLLFNNNKNNTILQFRPPRHALDLSITAAAHLIFGETLVPQTHFLGVINPRVTAAANEPSSSPPCDDTAEEVGGTTMIMLIYTHTLVRGVPLSTFLTLRLQEAKGTPPSPPLEGVVRSLAQQYFIPSLRHSLPPSSARLPVLKRAVGWGMRRQAERLLRGLPVRFRGVVGEVVAAMGEIEGWLPWGLTHGDFLGGGNVLVGFDGDEGGGGEGQEGKGEERLTGLVDWAEGEWLPFGVGLYGLEEVLGRTVTDGKGTRFEYYPDAERLRAAFWEEMVAAVPELACGSREREVVEKARLLGLLLWYGIAFDDGALNRVVQPGRDDEELQKLDLFLLGVCHDIKTSPIPSEQSGNLDEWQTVAGPAASHTQAQRWSEQGLSYAEALKRKFVPGSCRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P9F4</accession>
    <name>A0AAN6P9F4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_40298</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854542">
        <property type="protein sequence ID" value="KAK4033262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P9F4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="179"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4033262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="369" mass="39277" checksum="829EA1AA65F9F270" modified="2024-10-02" version="1">MQVFELRDIIRNSTSPADAALIDWDPYATTSSFYGPGALLCWLLVTVSYITKWVVAGSLLPEGLPGSMWLTSDFVAMVAYPLVAAGDAVIRAALLSPAARPHLMATMVAVRSNMNATTITPEVATDMDTLRACVGLSAPLRVCEVFLVPACIFLVVVLWDEPERGKLRLRSPLLWADMAFAATVLALLVATIVVAAVGTPGAIGDYLACVIASQIAAYFIIIATPGMPICGAWWYLANVVQVGHTSMFLGVWNLISLVCSIGPLVLVVLIPDFALDFFSLCVPDSGVSMGELDQAAAVCVGVFTLGITAYDVSGDIPMVAGFVRRSKIRLGLLREEREDEMPLTGDSGDTGDTGDLESQTEQHPGPHVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P9T1</accession>
    <name>A0AAN6P9T1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_18845</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854484">
        <property type="protein sequence ID" value="KAK4034330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P9T1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01370">
        <property type="entry name" value="KISc_KIP3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000053">
        <property type="entry name" value="Kinesin family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF13">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF19 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5 6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="9">
        <location>
            <begin position="7"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="610"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="875"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="903"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1049"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="353"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="688"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="722"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="755"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="799"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="837"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="878"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="953"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="1051"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="94"/>
            <end position="101"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4034330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1071" mass="115601" checksum="FCCFAE9C2AB76304" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P9Y2</accession>
    <name>A0AAN6P9Y2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_49156</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854479">
        <property type="protein sequence ID" value="KAK4034443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P9Y2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF6">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G16690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="397"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="429"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="41"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4034443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="488" mass="53982" checksum="76618D3AC31EAF91" modified="2024-10-02" version="1">MDSAEKTAVQQREAVGGATITMDPQRRVQVEKSLMRKLDARCSFFIILYIMNYLDRNNIAAARLKGLQADLNLSYNEYATCLSILYVGYILMQVPSNMVINLVSRPSIYIGASMLLWGLVSTLSGIVTNFAGMVVIRFFLGFVEAAFLPGALLILSKWYTRRELTTRNALLFCGNLISNAFSALVGAGVLSNMQGILGHAAWRWLFFIEGAATMFFAVCAIFILPDLPHNTRGFTEEECYVAQLRMTEDVGVADSDEPGQTPFTGLIMALKDPKVYLMMLTLTAYVVGLSFNAFFPTLTGTLGFDYVPTLLMSAPPWVFACLVSLLNAWHSDRTQDKFWHITGPILLGLIGFIISMSTLNVAARYLALFLQASSYAGFIVFYSWISSSFPRPPAKRAVAIAMINAFSQLGNVAGSYVWDLKADGYRKSYGIVTAMFGVTIAGCFVFKMVLVRMNAKLDQEDEGVAGQEKEVLEGADPERMNKGFRYLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PB23</accession>
    <name>A0AAN6PB23_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_48650</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854455">
        <property type="protein sequence ID" value="KAK4035086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PB23"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="1"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="254"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4035086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="345" mass="37969" checksum="900B3B0D99D1C5C6" modified="2024-10-02" version="1">MRFYSRTLTARPYFADDWLVVASLLSQFVMAGSIIAGVQLADVGYHVEYVQETNPAAITRFFQFLVFWSAWYLVTFPFPKLAICLMYRRLFPQRSVQIIMAVTAAILIGTAIGAFFADIFACRPFDTHWAHLEVQHAHCFDKEPLFVWSNFPNIVTDVVMLILPLPIVWKLHTPFRLKVALTGTFLVGSMGLVASILRFQSFANNNSFIDLTHTAVELLVWTLLEPGIYLISACLLMSRPLLDKFARKIGSGGHTQAGAYGSSGSRKLGRSVGRSVEDGDVNGSTIALGSKSAPGGGFRQLPDDGYDYPYPSSNIVVTTHIDQSWADGASIPMSNLATPGRQAGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PB38</accession>
    <name>A0AAN6PB38_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Obg-like ATPase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_38457</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854456">
        <property type="protein sequence ID" value="KAK4035065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PB38"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04867">
        <property type="entry name" value="TGS_YchF_OLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01900">
        <property type="entry name" value="YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.300:FF:000001">
        <property type="entry name" value="Ribosome-binding ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000001">
        <property type="entry name" value="Ribosome-binding ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.300">
        <property type="entry name" value="TGS-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00944">
        <property type="entry name" value="YchF_OLA1_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004396">
        <property type="entry name" value="ATPase_YchF/OLA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023192">
        <property type="entry name" value="TGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013029">
        <property type="entry name" value="YchF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041706">
        <property type="entry name" value="YchF_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00092">
        <property type="entry name" value="redox-regulated ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305">
        <property type="entry name" value="OBG GTPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305:SF11">
        <property type="entry name" value="OBG-LIKE ATPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06071">
        <property type="entry name" value="YchF-GTPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006641">
        <property type="entry name" value="CHP00092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="4">
        <location>
            <begin position="21"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="5">
        <location>
            <begin position="306"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="30"/>
            <end position="35"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4035065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="394" mass="43838" checksum="D7F7B48E60549609" modified="2024-10-02" version="1">MPPKKGAVEEKILLGRPGNNLKSGIVGLANVGKSTLFQAITKCNLGNPANFPYATIDPEEARVIVPDDRYDWLCEKYSPKSRVPANLTVYDIAGLTRGASTGAGLGNAFLSHIRAVDAIFQVVRCFDDAEIIHVEGDVNPTRDLDIISEELRLKDIEFVEKALENQKKKTRQGGQSLQMKQWKAEEATIEKILAWLKDGKDVRKGTWTPKEVEVINPLFLLSAKPAVYLVNLSERDYIRKKNKHLPKIVEWIKEHAEGDPIIPISVSFEERLTRFETEAEAAEECKKVGAESALPKIIIQMRKALNLGSFFTVGPDEVRQWTIRNGTKAPQAAGVIHTDFEKTFIQVIVYNYNVLKELGDESEVKAKGKVMTKGKDYVVEDGDILLIKAGAAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PBK8</accession>
    <name>A0AAN6PBK8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mitochondrial ribosomal protein MRP51</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_38108</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854444">
        <property type="protein sequence ID" value="KAK4035424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PBK8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070124">
        <property type="term" value="P:mitochondrial translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016712">
        <property type="entry name" value="Rbsml_bS1m-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28058">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN MRP51, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28058:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS1M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11709">
        <property type="entry name" value="Mit_ribos_Mrp51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="432"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4035424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="464" mass="50944" checksum="64218ACF50A5D95C" modified="2024-10-02" version="1">MAARSVSPGGALLRASRMFALPSPIPPPPNDSSAGTNFNSDTATLAFPTHQVITTLSSSRKQGDWGLKRPLPLKSTTKSSNPMLRVKAIDTIEQITDYSSATDHGITLRKFQELGMPLSARRPASGDMKDTTSTMNLPQKSVFEESFDMTDIHPDKRAEAMDSRWKFTGPWLAGMTQGEFNKWLAKHVRPKRPEFRQFLKKKIASELHAAAAKEALDKGLEQPALMDASAVTEDQLIDYLRKLRHDNQALYDMVGQFLDLAPLAPPTVSQTGLPKEKVSTLTFNEMKNPYAERGPPITHPSAGLSYLRTSMYMENHPIYGPQKHHTPVVARVLRPRRQAQAAAARLGVAGFVVNTPLGDTGFNSRSGHAVFDKIDPTVEGGAKVWVQAQRASVDSSGRVVLTVNDTTREAQLVAQELLGEAVCLGVQPAENEMNKRESASDIRQRYRAADSPAMSSAQDYGLRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PBU7</accession>
    <name>A0AAN6PBU7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein Red</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_40424</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854550">
        <property type="protein sequence ID" value="KAK4033137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PBU7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039896">
        <property type="entry name" value="Red-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012916">
        <property type="entry name" value="RED_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12765">
        <property type="entry name" value="RED PROTEIN IK FACTOR CYTOKINE IK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07808">
        <property type="entry name" value="RED_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RED-like N-terminal" evidence="4">
        <location>
            <begin position="84"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="161"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="241"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="325"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="422"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="161"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
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            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="212"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="254"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="354"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="392"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="429"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="498"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4033137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="529" mass="58713" checksum="C530C7947D7ECCF9" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PC19</accession>
    <name>A0AAN6PC19_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Armadillo-type protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_37966</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">RNA-binding nucleolar protein required for pre-rRNA processing. Involved in production of 18S rRNA and assembly of small ribosomal subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854439">
        <property type="protein sequence ID" value="KAK4038126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PC19"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010608">
        <property type="term" value="P:post-transcriptional regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07920">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000237">
        <property type="entry name" value="Pumilio homolog 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033712">
        <property type="entry name" value="Pumilio_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537:SF13">
        <property type="entry name" value="PUMILIO HOMOLOGY DOMAIN FAMILY MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537">
        <property type="entry name" value="RNA BINDING PROTEIN PUMILIO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PUM-HD" evidence="6">
        <location>
            <begin position="567"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="593"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="629"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="665"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="702"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="738"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="774"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="810"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="846"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="113"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="293"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="430"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="66"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="253"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="448"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="477"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4038126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1017" mass="110938" checksum="9D7C861887D9CF47" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PCP6</accession>
    <name>A0AAN6PCP6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_38452</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854456">
        <property type="protein sequence ID" value="KAK4035060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PCP6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016274">
        <property type="term" value="F:protein-arginine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.160.11:FF:000001">
        <property type="entry name" value="Blast:Protein arginine N-methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000050">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055135">
        <property type="entry name" value="PRMT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006:SF53">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22528">
        <property type="entry name" value="PRMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
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    </dbReference>
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    <keyword evidence="1 4 7" id="KW-0489">Methyltransferase</keyword>
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    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="5">
        <location>
            <begin position="64"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Protein arginine N-methyltransferase" evidence="6">
        <location>
            <begin position="166"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF22528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4035060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="345" mass="39547" checksum="84E73259CE98FA26" modified="2024-10-02" version="1">MAGEKMDIEVAEKQLKSLDHSEQHYFNSYNHHGIHEEMLKDEVRTRSYMNAIVQNKHIFKDKIVLDVGCGTGILSMFAAKAGAKHVIGVDMSTIIFKAREIVKVNGLSDKITLIQGKMEEIEMPFPKVDIIISEWMGYFLLYESMLDTVLYARDRYLNKDGLIFPDKATIFVAGIEDGDYKEEKIGFWDNVYGFDYSPLKETALSEPLVDTVEMKAVVTDPTPVLTLDLYKVTTADLAFSCPFDLTARRDDFIHALVAWFDIEFTACHKPIRFSTGPHTKYTHWKQTVFYLQDVLTVEQGEKVECALHNRPNDKNKRDLDIKVEYRLETQDPNRQAGGACLYKMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PCX4</accession>
    <name>A0AAN6PCX4_9PEZI</name>
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        <submittedName>
            <fullName evidence="2">Prokaryotic phospholipase A2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_48567</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854452">
        <property type="protein sequence ID" value="KAK4035180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PCX4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050482">
        <property type="term" value="P:arachidonate secretion"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.90.10">
        <property type="entry name" value="Phospholipase A2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036444">
        <property type="entry name" value="PLipase_A2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015141">
        <property type="entry name" value="PLipase_A2_prok/fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40787:SF3">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40787">
        <property type="entry name" value="SECRETED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09056">
        <property type="entry name" value="Phospholip_A2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48619">
        <property type="entry name" value="Phospholipase A2, PLA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042976364" evidence="1">
        <location>
            <begin position="17"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4035180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="183" mass="20449" checksum="3F9D5C80866CCC0F" modified="2024-10-02" version="1">MKFLTSILCLASSALALPAPSETDASLIQRQTASEITDQYLYSITLPTFTARRNARDPATLIWDSDGCSSSPDNPFGFPFVPACHRHDFGYRNYKAQNRFTDAGKLKVDNNFKKDLYYQCSSVSAKGVCEALADVYYAAVRAFGGSTQEKRDDDLVREYEEKVAIYKKLVAEAQASGELWRVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PCY7</accession>
    <name>A0AAN6PCY7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_37434</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854424">
        <property type="protein sequence ID" value="KAK4038598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PCY7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042946205" evidence="2">
        <location>
            <begin position="25"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="117"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4038598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="130" mass="13491" checksum="6A290E61859A3041" modified="2024-10-02" version="1">MRNHILLPALQFAAAAFFAKAALAAPTADNTDTNTNTQTYCVDGNHRVVATSNCDDVAVGGGKLMTVQGPPGLEIGDLHVPAGSQARNVAREQQQGDDDDDMVSGGFGEVEQRDEATSTTSSRGSRPTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PD42</accession>
    <name>A0AAN6PD42_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_18651</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854474">
        <property type="protein sequence ID" value="KAK4034568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PD42"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4034568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="156" mass="17136" checksum="C8A75DB97F16F3CB" modified="2024-10-02" version="1">MGQPSQAGAAQLSSQHERLLVELLPVKDASQFHEWLNGEYVRGSWDEFLRDFLLANPGGPDPDKASTAQKARDALNSRGAMCMMHNPFKQSWSAEDHHVRFIAAVVSDNMVGGLRFEKDWKKSSLAIAGAVFEVLVYLKATAVPGAPDANPPRYEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PEN6</accession>
    <name>A0AAN6PEN6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secretory lipase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_18269</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854458">
        <property type="protein sequence ID" value="KAK4035001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PEN6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005152">
        <property type="entry name" value="Lipase_secreted"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853:SF5">
        <property type="entry name" value="LIP-DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03583">
        <property type="entry name" value="LIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042887469" evidence="2">
        <location>
            <begin position="21"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4035001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="446" mass="48819" checksum="C8D0239FD90FE7FC" modified="2024-10-02" version="1">MALFALLLLLWGNLLPFSAAVPLQTLQQLIHQADADAATPPSSYTPLPPSLDPWYRPPLTYDWTQTSPGRVLKIRQSPLLNLTVGNALLAYQLLYRSTDSAYNPAWDVTTLFIPRWQARCSASTPNLCAHALLSYQLPYDTCNVDASPSFGLHFGEPYGEIADALGLGWFVAVPDYEGPLASYAAGVQAGHATLDGVRAVMQVAGLFGLRVGVAKVGLWGYSGGALAAEWAAELAVQYAPKMRIAGVALGGLTPNVTGVTEFLNGREGAGLIPQGLLGIATQHPDAYRWIVSRLRPALREVFLSVRRMTAAQAIAAFRYQDIYGYFVGGYADLHTRVMQMMYNVDGFMGYHGVPRMPVFIYNAINDELSDIRDVDELVDRFCGVGANILYHRNTVGTHTQELINGRQRAFAWLRSVLDGSYDQLYSSMGCTIQNVTYNLAPWVGWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PF44</accession>
    <name>A0AAN6PF44_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Alpha-galactosidase</fullName>
            <ecNumber evidence="3 7">3.2.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Melibiase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_38686</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="3 7"/>
    <dbReference type="EMBL" id="MU854463">
        <property type="protein sequence ID" value="KAK4034862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PF44"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14792">
        <property type="entry name" value="GH27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002241">
        <property type="entry name" value="Glyco_hydro_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041233">
        <property type="entry name" value="Melibiase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452:SF61">
        <property type="entry name" value="ALPHA-GALACTOSIDASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452">
        <property type="entry name" value="ALPHA-GALACTOSIDASE/ALPHA-N-ACETYLGALACTOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16499">
        <property type="entry name" value="Melibiase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17801">
        <property type="entry name" value="Melibiase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00740">
        <property type="entry name" value="GLHYDRLASE27"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042922904" description="Alpha-galactosidase" evidence="8">
        <location>
            <begin position="21"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha galactosidase C-terminal" evidence="9">
        <location>
            <begin position="333"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4034862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="437" mass="48665" checksum="269CFE3885F7B7A7" modified="2024-10-02" version="1">MAATTTSILLGLLYATGATALDNGVGKLPALGFNTWNMYQCDYTADMLLQQAQALVDHGLVKAGYNTFMLDDCYSLKERDKKGRIVEDPEKFPKGMKHFTKSLSKLGFRAGIYSDAGYRTCGGYPGSFGNEAKDLETFADWGFSYLKYDNCFIPFDNVTQENVYGRYARMADAIDARAKKTKSQPVQLALCEWGWQQPWIWAGRLGQSWRTGGDIRPWWSALSAIINHASFIATETRFFARNDLDILEVGNTNQGTPPGNLTYDEAKSHFTAWALLKSPLLISSDMATASKETIEILENKDILKINQDPNVGEALAPFRWGFNEDFTFDPAHPAEYWTGNSSYGVVFMVLNTQDTPQHMSFNLTESWAIRAGRVYSVYDLWTHTNNGTASRSISLNLPAHGVAALLLNDAGPEPAGTEPYCAGWWQCSFPNGTYYSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PFA9</accession>
    <name>A0AAN6PFA9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_16944</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854412">
        <property type="protein sequence ID" value="KAK4039043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PFA9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF10">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="89"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="115"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="697"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="133"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="166"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="209"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4039043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="717" mass="80267" checksum="385E7EA1301A9530" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PG49</accession>
    <name>A0AAN6PG49_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">Long-chain-alcohol oxidase</fullName>
            <ecNumber evidence="5 12">1.1.3.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">C8A01DRAFT_46498</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Long-chain fatty alcohol oxidase involved in the omega-oxidation pathway of lipid degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>a long-chain primary fatty alcohol + O2 = a long-chain fatty aldehyde + H2O2</text>
            <dbReference type="Rhea" id="RHEA:22756"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17176"/>
            <dbReference type="ChEBI" id="CHEBI:77396"/>
            <dbReference type="EC" id="1.1.3.20"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.3.20" evidence="5 12"/>
    <dbReference type="EMBL" id="MU854384">
        <property type="protein sequence ID" value="KAK4040097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PG49"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046577">
        <property type="term" value="F:long-chain-alcohol oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012400">
        <property type="entry name" value="Long_Oxdase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46056">
        <property type="entry name" value="LONG-CHAIN-ALCOHOL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46056:SF12">
        <property type="entry name" value="LONG-CHAIN-ALCOHOL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028937">
        <property type="entry name" value="Lg_Ch_AO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="14">
        <location>
            <begin position="284"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase C-terminal" evidence="15">
        <location>
            <begin position="590"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR028937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR028937-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK4040097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="747" mass="81175" checksum="5180F3181306E2C0" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PG58</accession>
    <name>A0AAN6PG58_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">ATP-dependent bile acid permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">C8A01DRAFT_35984</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854386">
        <property type="protein sequence ID" value="KAK4040017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18596">
        <property type="entry name" value="ABC_6TM_VMR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18604">
        <property type="entry name" value="ABC_6TM_VMR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000825">
        <property type="entry name" value="ABC bile acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
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        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
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        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
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    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="ABC_TRANSPORTER_2"/>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="337"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="504"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="533"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="611"/>
            <end position="638"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1039"/>
            <end position="1063"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1121"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1196"/>
            <end position="1217"/>
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    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1223"/>
            <end position="1243"/>
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    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="340"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="711"/>
            <end position="960"/>
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    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="1043"/>
            <end position="1361"/>
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    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="1402"/>
            <end position="1682"/>
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    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="69"/>
            <end position="97"/>
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    <feature type="region of interest" description="Disordered" evidence="10">
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    </feature>
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            <begin position="1705"/>
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        <location>
            <begin position="970"/>
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        <location>
            <begin position="995"/>
            <end position="1017"/>
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            <begin position="1537"/>
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            <begin position="1706"/>
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        <source>
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        <source>
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    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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        <source>
            <dbReference type="PROSITE" id="PS50893"/>
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        <source>
            <dbReference type="PROSITE" id="PS50929"/>
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        <source>
            <dbReference type="EMBL" id="KAK4040017.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1732" mass="191153" checksum="BC0FFAECF855AD75" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PG94</accession>
    <name>A0AAN6PG94_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Glycoside hydrolase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_37642</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="entry name" value="Glyco_hydro_2_N"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="2 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042907719" evidence="4">
        <location>
            <begin position="17"/>
            <end position="856"/>
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    </feature>
    <feature type="domain" description="Glycosyl hydrolases family 2 sugar binding" evidence="7">
        <location>
            <begin position="117"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich" evidence="5">
        <location>
            <begin position="224"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2 catalytic" evidence="6">
        <location>
            <begin position="346"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4982" evidence="8">
        <location>
            <begin position="677"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2" evidence="9">
        <location>
            <begin position="749"/>
            <end position="852"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF18565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4038399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="856" mass="92857" checksum="2F6E037941EE442A" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PGY9</accession>
    <name>A0AAN6PGY9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Armadillo-type protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">C8A01DRAFT_45979</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. Involved in pre-tRNA splicing, probably by affecting the interaction of pre-tRNA with splicing endonuclease.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854371">
        <property type="protein sequence ID" value="KAK4040691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PGY9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000244">
        <property type="entry name" value="Nonsense-mediated mRNA decay protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013713">
        <property type="entry name" value="XPO2_central"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF18">
        <property type="entry name" value="D-IMPORTIN 7_RANBP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08506">
        <property type="entry name" value="Cse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="10">
        <location>
            <begin position="24"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="914"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="917"/>
            <end position="940"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK4040691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1054" mass="120501" checksum="0FF391458C6DB1F6" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PHU5</accession>
    <name>A0AAN6PHU5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peroxisomal membrane protein PEX16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_46260</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peroxin-16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854378">
        <property type="protein sequence ID" value="KAK4040363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PHU5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013919">
        <property type="entry name" value="Pex16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13299">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13299:SF0">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08610">
        <property type="entry name" value="Pex16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="2" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="152"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="160"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="203"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU365003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4040363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="373" mass="41994" checksum="994D1021E3F404D1" modified="2024-10-02" version="1">MYDEFITKNAHQVSQIESTLRSLTYIIPGRFRDAEIASESIHSGVQLLSLYHDTLLRRAHKLTKLPVPPSLSQPPSSHGRYTRFWTLRSALYRRVAYVLQIVHYVELLCEMAAKRRGERVRWRVVVLLEAVKAVCRLLLMRITRSRPLVTPVLPEREPVPDEPADEEEGGGGEEFGGLGEDDEDRRNGGAYANGSAQNHRESSSQLGPNGEWTMSRTGMSLPCLPAPGDTSGYLLSRVLTADDIKPAAKLLNRLQGQAQAAEILHILAPLIFAVALARSRDKRKAWAPWLLGVGAELAARQLRDRGLRTTPLEREEWARRGWAMGWWAMRGAFYENVTKGVVAGVRRRMPGLLAGILEDYEYLWENYHFSTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PI58</accession>
    <name>A0AAN6PI58_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_47464</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854413">
        <property type="protein sequence ID" value="KAK4039010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PI58"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF6">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4039010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="552" mass="62969" checksum="E81C01D2834CE6CF" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PIC0</accession>
    <name>A0AAN6PIC0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7730 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_34446</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854356">
        <property type="protein sequence ID" value="KAK4041493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PIC0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056632">
        <property type="entry name" value="DUF7730"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24864">
        <property type="entry name" value="DUF7730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7730" evidence="2">
        <location>
            <begin position="198"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4041493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="462" mass="51728" checksum="3C1A0E6AE0726A5E" modified="2024-10-02" version="1">MSTENRGSVSHGLRRLFHKVRGRNSADGTGDNNAIQNELPPLPFLPAQRPRPLTPSASEQSPVTLGTLARLPAELRCRILMAAFGGRTLHLDLRLAHPRRPDDLAAPVSGHHEYEHDLGAAPLSEYYGPDEASPKTWRWYSSVCHRMEPPGSRWEHRSVRLGYPVYRYPHTDGCLRGEAMCCALWPPESAAGIQGKCRVGVMGWLLACRQAYAEAIDLLYATNTFFVESDALLDNLVCPGPATGSTNHLLLPERMAQITSLELRWEVLIFGQPSASWGERFAVAQNTEANRAKLAAHLRHLCSTFPNLRSLVLSFSDPLYNVRGVQPAYALAEIDRVLLRPIADAVARLPLSAQRKRVVVELPSNVFSELNGIKHKGLPGLELEEEQKERVVDDGRGLWLRYPLSARPSRQPRQGSPDAESESGSSDYDFYYIKQGVESLFLYWDYDGNPRSYRYEKCSMPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PIE7</accession>
    <name>A0AAN6PIE7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glutathionylspermidine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_45472</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854359">
        <property type="protein sequence ID" value="KAK4041312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PIE7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005494">
        <property type="entry name" value="GSPS_pre-ATP-grasp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03738">
        <property type="entry name" value="GSP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043052094" evidence="6">
        <location>
            <begin position="19"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="Glutathionylspermidine synthase pre-ATP-grasp-like" evidence="7">
        <location>
            <begin position="27"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4041312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="427" mass="48404" checksum="8FE410AB339B6C33" modified="2024-10-02" version="1">MSQWAMLALVIIEATVGGMTPAPGDPSDPYWPDDRYYSFTSEEIALLEKAGQDVFAMCCEATDFLVENRELITSQLAIPAFALQQIKKSWDREPPWGSVYGRFDVCFGGLNHPDPRLRVPKLYEFNADTPVLLVESASIQWLWLEQTGHGNDQLNSITERLIEAHRVKVHFAYTRGEPTGEHAMNTTLLMDTCQQAGWPTKTLFMEQIGLSSRDRRFYDQEGEHIDVIFKLYPWRYMVESKFGEAYFKDMERIGQRNKVGEYIGGTVWIEPPYKMLWSNKALFAILWQLFKNDPRSQWLLPTYFDTEAPASLTSFARKPIFAGQGADVVLQADGRVIQDTTTGDYGKEGYVVQELALLPEFKAVGNVSYYPVLSLWVVDGKVSGMGVREDKTPITTNGSMFIPHSISDGPINYERQSVPNIDEIEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PJ20</accession>
    <name>A0AAN6PJ20_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Tryptophan synthase beta subunit-like PLP-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_36588</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1-aminocyclopropane-1-carboxylate + H2O = 2-oxobutanoate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16933"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16763"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:58360"/>
            <dbReference type="EC" id="3.5.99.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ACC deaminase/D-cysteine desulfhydrase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854400">
        <property type="protein sequence ID" value="KAK4039460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PJ20"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008660">
        <property type="term" value="F:1-aminocyclopropane-1-carboxylate deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019148">
        <property type="term" value="F:D-cysteine desulfhydrase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009310">
        <property type="term" value="P:amine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06449">
        <property type="entry name" value="ACCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027278">
        <property type="entry name" value="ACCD_DCysDesulf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005965">
        <property type="entry name" value="ACP_carboxylate_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01274">
        <property type="entry name" value="ACC_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43780">
        <property type="entry name" value="1-AMINOCYCLOPROPANE-1-CARBOXYLATE DEAMINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43780:SF2">
        <property type="entry name" value="1-AMINOCYCLOPROPANE-1-CARBOXYLATE DEAMINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006278">
        <property type="entry name" value="ACCD_DCysDesulf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="8">
        <location>
            <begin position="20"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR006278-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR006278-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4039460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="352" mass="38044" checksum="BDBFA59D9433255C" modified="2024-10-02" version="1">MTSVKLPEPFASIPREILTFGPSPIHHLPRISQALGGKVNVYAKREDCNSGLAYGGNKTRKLEYLLPDALAQGCDTLVSIGGVQSNHTRQVAAAAAKLGLQVALVQEHWVDGWTDAGYDKVGNIQLSRLMGADVRLEDPSSLTFGIEHKPTLARLQEELVAKGARPYYIPAGASDHPLGGLGFARWAFEVEAQEREMGVFFDTVIVCAVTGSTMAGMVAGFKMIEKKLGGRKRRVVGIDASAKVRQTFEQVLRIARQTAVKIGLEEGDVAEEDIVLDERYHAGTYGLPDEQTIEAIKFGARTEAFITDPVYEGKSLAGMMDMIRKVEIADGSNVLYAHLGGQLALNAYSALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PJ39</accession>
    <name>A0AAN6PJ39_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_34044</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854349">
        <property type="protein sequence ID" value="KAK4041934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PJ39"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4041934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="410" mass="44662" checksum="27C9BFEAA2BB1557" modified="2024-10-02" version="1">MDDNGLEPLKMAVAANDDILDSVTKRLSEAAESDSASLREEAIQMMELLNQAHFLHQETKRTLMLARQHEAKMKAMAEERERAVQSLTSTIDVIQKVPDSLAKQASANAGLDAKLDAIAANGVTKDDLGGLKQEMQHIREQIQEMSARRNRVRQPLETAAASKPAAAADAVTALEVAAAFESAAASEPATAFEAAAALEVAAAREAVAASNATAAPETDVHNPDPASLDGPLAAVGDKDTGEREAKRIRTEEPDTQPVCPPQPVQPKLSDDEQRRLAQLTEICSADEKHWKPVEILQSLQALCDEYPVAAKAILACMDHQRGQQWYCVRSVVMEFHKSAYITPTTTEQGDGTCCYCSKNCLQITAQKPGNHSGWWRTGSREGPGLFGFYSQERRQKKRGRQGLFGQVPYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PJ81</accession>
    <name>A0AAN6PJ81_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_35986</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854386">
        <property type="protein sequence ID" value="KAK4040019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PJ81"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4040019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="61" mass="6459" checksum="94E5BD3354A4FB5C" modified="2024-10-02" version="1">MGGTDTHDIPMPDIPVYVYVVSGLLVGSLVGTQLLGMWLTGFRKPVPVRGAFDPLTGKVMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PJA3</accession>
    <name>A0AAN6PJA3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_46486</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854383">
        <property type="protein sequence ID" value="KAK4040171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PJA3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF12">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4040171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="553" mass="60057" checksum="502617FF6792CCF7" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PJE1</accession>
    <name>A0AAN6PJE1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_34899</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854364">
        <property type="protein sequence ID" value="KAK4041055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PJE1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4041055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="468" mass="52086" checksum="96917921ACC6C2B5" modified="2024-10-02" version="1">MDKLPAEIIHLIISHLEPPLAGYATVSSRWQDAIESHTLRSIGASSDDASFGQFQAVFATPRRRALLRKLVFHVQLPPPSEKRIRKLQSRREAAANNLAYTRALVALFSYLHTWEHEEGAARLALEVSVSSPMDNYDGDDKGHRGVPIWFIRDQLRQVSVDTDVLRESGGLATVRVVSGLTNYHHIGLGCGRRVDPAVMPLVTKALPNAREMNWAFSALPRRFPDLRRAERMSLANALFATAAADIRLLTTLQISWEDRAPCNEASDPGSLVDGASSRDDLSIALRRISQLPSLRSLKLTGSHTIGAQLFEDQNVSPDHGAPTWPSLTNLEIWASVTTPDGRWYFTGDPSSAEFIDQQQDDSDESVAAFDSADADTSDFAPDFAWEREDGMVPWRVFRTTPDCAIFVPFMVSMLRAVARMPVLRHLTFCMQLESRIGVYLDYFGPGEPRKGPVVGLEPAFHKAHLEQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PJT0</accession>
    <name>A0AAN6PJT0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glucoamylase</fullName>
            <ecNumber evidence="9">3.2.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">1,4-alpha-D-glucan glucohydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Glucan 1,4-alpha-glucosidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">C8A01DRAFT_33643</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Hydrolysis of terminal (1-&gt;4)-linked alpha-D-glucose residues successively from non-reducing ends of the chains with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.3" evidence="9"/>
    <dbReference type="EMBL" id="MU854343">
        <property type="protein sequence ID" value="KAK4042294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PJT0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004339">
        <property type="term" value="F:glucan 1,4-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001070">
        <property type="term" value="F:starch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000018">
        <property type="entry name" value="Glucoamylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002044">
        <property type="entry name" value="CBM20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011613">
        <property type="entry name" value="GH15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000165">
        <property type="entry name" value="Glucoamylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046966">
        <property type="entry name" value="Glucoamylase_active_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008291">
        <property type="entry name" value="Glucoamylase_SBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31616:SF12">
        <property type="entry name" value="GLUCOAMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31616">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00686">
        <property type="entry name" value="CBM_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00723">
        <property type="entry name" value="Glyco_hydro_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001031">
        <property type="entry name" value="Glu-a-glcsd_SBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00736">
        <property type="entry name" value="GLHYDRLASE15"/>
    </dbReference>
    <dbReference type="SMART" id="SM01065">
        <property type="entry name" value="CBM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="Starch-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51166">
        <property type="entry name" value="CBM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00820">
        <property type="entry name" value="GLUCOAMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042956515" description="Glucoamylase" evidence="12">
        <location>
            <begin position="21"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="domain" description="CBM20" evidence="13">
        <location>
            <begin position="504"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR001031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001031-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001031-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK4042294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="623" mass="66394" checksum="AA1D93DF4434DCB3" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PJT7</accession>
    <name>A0AAN6PJT7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA 3'-terminal phosphate cyclase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_44960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854348">
        <property type="protein sequence ID" value="KAK4041982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PJT7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003963">
        <property type="term" value="F:RNA-3'-phosphate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.20">
        <property type="entry name" value="RNA 3'-terminal phosphate cyclase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.20">
        <property type="entry name" value="RNA 3'-terminal phosphate cyclase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023797">
        <property type="entry name" value="RNA3'_phos_cyclase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037136">
        <property type="entry name" value="RNA3'_phos_cyclase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000228">
        <property type="entry name" value="RNA3'_term_phos_cyc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036553">
        <property type="entry name" value="RPTC_insert"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096">
        <property type="entry name" value="RNA 3' TERMINAL PHOSPHATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096:SF0">
        <property type="entry name" value="RNA 3'-TERMINAL PHOSPHATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01137">
        <property type="entry name" value="RTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="EPT/RTPC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA 3'-terminal phosphate cyclase" evidence="1">
        <location>
            <begin position="15"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4041982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="418" mass="45148" checksum="43EF5BCB6C921E01" modified="2024-10-02" version="1">MKEKTPIIELDGRTGEGGGQLVRIACALAAVVSQPIRITNVRGNREGPRGGGLKSQHVTAIDFLAKATAADVSGLSIGSHTLEFSPQLRPSALKNRNIKITADSPAASTMLIFQAVFPFLLFAGNDKGEPITLEISGGTNVSFSLSFEYLDQVLLPTLQDAFGIQVERKLLARGWSLGRQQRGKVEFKFKPLKPGETLKLKEKDGVVYGGDGPLPVVEDIEGIDVSMIVPLEMRESMTEALVADLEQLFPDVEVDFKITEDSGAESRIYVLLVAKAGTVRWGRDSLSSMPKKAKGKGGVQTPSSLSATISRKISKELYEEVSNGGVVDEFLQDQLAIFQALAEGRTSFPRGEAKDSLEQAVAKLAVDEKLRKEKADKPFGEGSTHTTTARWVTAELLPRVGWYNKGSLCEGIGMQSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PJX2</accession>
    <name>A0AAN6PJX2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_46134</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854375">
        <property type="protein sequence ID" value="KAK4040501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PJX2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="859"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1049"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="162"/>
        </location>
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            <end position="229"/>
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            <end position="350"/>
        </location>
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            <end position="411"/>
        </location>
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            <end position="461"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK4040501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1075" mass="117580" checksum="3D788F276660C577" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854340">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="entry name" value="DUF3433"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544:SF1">
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    </evidence>
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</entry>
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
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                <person name="Brannstrom I.O."/>
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                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
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                <person name="Natvig D.O."/>
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                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
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                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
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                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4041610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="443" mass="49122" checksum="E13918513C8D260B" modified="2024-10-02" version="1">MATDSCRGALYCSENCAEVNANRHRKLCFKYKTAKHPDGGNHARAVLFPAGKPKPEILFVHVNHWNANVEHVVCAAATQPADSPVVTITMPVNPVTGRRLPFDLKITFRACTVPLNTALTFCFNDNWELPVPRFPWTGSISVVRVQQGTDIAEDITMADYKDVLDFFAWYAHHFTPEMFEYVHEYAMPAAAAPICGVMVRCAATEALGPEQGALVATMVDHLHPIRGLHTADGFKLTLSRTLLLRRARLAAELMVDMAAYAAAPMPPGPVSEFIPEIHGDVLLVREDGLDLAVDDVAAMCLEVRSWMSSVATQGQQPAHDLPAPNNYQHANAIGGPLPQVWKHDQTMPSLWTRVKTPGGWDNLAAAILFEGYSFQPPAFLGDAVGGEEYAVDREEYMERAEEQQEGGDQEMVYQYPSPPPRRYNYSADIMPESEVPWFEPMEE</sequence>
</entry>
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        <name evidence="2" type="ORF">C8A01DRAFT_33220</name>
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        <name type="scientific">Parachaetomium inaequale</name>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
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                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854337">
        <property type="protein sequence ID" value="KAK4042692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <begin position="71"/>
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    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4042692.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
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    </evidence>
    <sequence length="96" mass="10928" checksum="B7B441DEBEEA4098" modified="2024-10-02" version="1">MPTRTRLAARPLQTLSRTRQHQPIHRPFSIMHNLRTIARSFEPHPFQRLPVASTPAPADWARLVRRSLGQAVVYFPAFAVMLGWPYAAAVVLDGRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAN6PKX4_9PEZI</name>
    <protein>
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            <fullName evidence="3">Cytokinin riboside 5'-monophosphate phosphoribohydrolase</fullName>
        </recommendedName>
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    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_44105</name>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
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                <person name="Guillou S."/>
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                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854334">
        <property type="protein sequence ID" value="KAK4042888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PKX4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0016799">
        <property type="term" value="F:hydrolase activity, hydrolyzing N-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0009691">
        <property type="term" value="P:cytokinin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.450:FF:000018">
        <property type="entry name" value="Lysine decarboxylase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005269">
        <property type="entry name" value="LOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031100">
        <property type="entry name" value="LOG_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00730">
        <property type="entry name" value="Rossman fold protein, TIGR00730 family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31223">
        <property type="entry name" value="LOG FAMILY PROTEIN YJL055W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31223:SF70">
        <property type="entry name" value="LOG FAMILY PROTEIN YJL055W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03641">
        <property type="entry name" value="Lysine_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102405">
        <property type="entry name" value="MCP/YpsA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4042888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="233" mass="24882" checksum="DEE76334A0E03212" modified="2024-10-02" version="1">MASNGNGASPSKRTKICVYCGSSAGNKPEHVEAARALARAMAANNIALVYGGGTVGLMGEVAKTLVALSGPDAVHGIIPEALVRYERDPTYTSKQLHGEEGAHMAVPEEAVFGRTTIVKDMHTRKRLMAQEVINGGPGSGFVALSGGYGTLEELFETATWNQLGIHNKGICVLNINGFYDGILAWINKSVEEGFIHGDNKFILAEAKTAEEAITALREYKVSEAVYKLSWGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PL70</accession>
    <name>A0AAN6PL70_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16 17">Phosphatidylethanolamine N-methyltransferase</fullName>
            <shortName evidence="16">PE methyltransferase</shortName>
            <shortName evidence="16 17">PEAMT</shortName>
            <shortName evidence="16">PEMT</shortName>
            <ecNumber evidence="16 17">2.1.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">C8A01DRAFT_13554</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15 16 17">Catalyzes the first step of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 17">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine = a 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11164"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64573"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="EC" id="2.1.1.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 16 17">Phospholipid metabolism; phosphatidylcholine biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16 17">Endoplasmic reticulum membrane</location>
            <topology evidence="16 17">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16 17">Belongs to the class VI-like SAM-binding methyltransferase superfamily. CHO2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16 17">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.17" evidence="16 17"/>
    <dbReference type="EMBL" id="MU854335">
        <property type="protein sequence ID" value="KAK4042827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PL70"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004608">
        <property type="term" value="F:phosphatidylethanolamine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006656">
        <property type="term" value="P:phosphatidylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.2840:FF:000006">
        <property type="entry name" value="Phosphatidylethanolamine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03217">
        <property type="entry name" value="PEMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007318">
        <property type="entry name" value="Phopholipid_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016219">
        <property type="entry name" value="Phosphatid-EA_MeTrfase_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32138">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32138:SF0">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04191">
        <property type="entry name" value="PEMT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000383">
        <property type="entry name" value="PEAMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51598">
        <property type="entry name" value="SAM_CHO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16 17" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 16 17" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11 16 17" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 16 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 16 17" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13 16 17" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="14 16 17" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 16 17" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 16 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 16 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16 17">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16 17">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16 17">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16 17">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16 17">
        <location>
            <begin position="378"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16 17">
        <location>
            <begin position="402"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16 17">
        <location>
            <begin position="482"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16 17">
        <location>
            <begin position="563"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="326"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="18"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="344"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00057332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU361122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAK4042827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="952" mass="107034" checksum="F35D87E5A7367DFB" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PL80</accession>
    <name>A0AAN6PL80_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Armadillo-type protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_34064</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. Involved in pre-tRNA splicing, probably by affecting the interaction of pre-tRNA with splicing endonuclease.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854349">
        <property type="protein sequence ID" value="KAK4041953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PL80"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000266">
        <property type="entry name" value="mRNA transport regulator MTR10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051345">
        <property type="entry name" value="Importin_beta-like_NTR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057941">
        <property type="entry name" value="TPR_TNPO3_IPO13_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057942">
        <property type="entry name" value="TPR_TNPO3_IPO13_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058537">
        <property type="entry name" value="TPR_TNPO3_IPO13_4th"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12363:SF53">
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            <end position="100"/>
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        <source>
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        </source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK4041953.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
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</entry>
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            <fullName evidence="2">PH domain-containing protein</fullName>
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
    <dbReference type="InterPro" id="IPR058155">
        <property type="entry name" value="Skg3/CAF120-like_PH"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="1147"/>
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    </feature>
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        <source>
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        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PLJ6</accession>
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        <name evidence="6" type="ORF">C8A01DRAFT_15415</name>
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    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="term" value="P:microtubule cytoskeleton organization"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
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        <property type="entry name" value="ARM_TBCD_2nd"/>
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        <property type="entry name" value="HEAT_type_2"/>
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        <property type="entry name" value="TBCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022577">
        <property type="entry name" value="TBCD_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12658">
        <property type="entry name" value="BETA-TUBULIN COFACTOR D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12658:SF0">
        <property type="entry name" value="TUBULIN-SPECIFIC CHAPERONE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23579">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="414"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="2">
        <location>
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            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin-folding cofactor D ARM repeats" evidence="5">
        <location>
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        </location>
    </feature>
    <feature type="domain" description="Tubulin-folding cofactor D C-terminal" evidence="4">
        <location>
            <begin position="958"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1151"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1151"/>
            <end position="1169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF12612"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF25767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4040735.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1244" mass="134831" checksum="F36F5727FB81B70E" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PLN1</accession>
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        <submittedName>
            <fullName evidence="3">SGNH hydrolase-type esterase domain-containing protein</fullName>
        </submittedName>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854329">
        <property type="protein sequence ID" value="KAK4043314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PLN1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01821">
        <property type="entry name" value="Rhamnogalacturan_acetylesterase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037459">
        <property type="entry name" value="RhgT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43695">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G17250)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43695:SF2">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G17250)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042838033" evidence="1">
        <location>
            <begin position="18"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="2">
        <location>
            <begin position="35"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4043314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="247" mass="25755" checksum="FE8A75A362FDB96B" modified="2024-10-02" version="1">MKFSPLALLAAPLLAMAAPLVDCAAAKTPAFFLAGDSTTAVDGGWGDGFVDLLRNGAIGQNKGHSGATTASFVAGGDWKAVLDLVKNNKAKHDCYVTIQFGHNDQKATSGLSIAQFQTNLQNMANEVKSAGATPIILTSLTRRTFKSGVLDDSLANVSEAAKKAAAAVGVTMLDLNAASRKYVQAIGQSNADTYNLAEGDRTHLNDHGMAVFARMVADLILGWKPALSASITRDEALSKKIADGVYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PMT4</accession>
    <name>A0AAN6PMT4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dephospho-CoA kinase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_43121</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854322">
        <property type="protein sequence ID" value="KAK4043953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PMT4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004140">
        <property type="term" value="F:dephospho-CoA kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02022">
        <property type="entry name" value="DPCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001227">
        <property type="entry name" value="Dephospho-CoA kinase CAB5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00376">
        <property type="entry name" value="Dephospho_CoA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001977">
        <property type="entry name" value="Depp_CoAkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00152">
        <property type="entry name" value="dephospho-CoA kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695:SF46">
        <property type="entry name" value="BIFUNCTIONAL COENZYME A SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695">
        <property type="entry name" value="DEPHOSPHO-COA KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01121">
        <property type="entry name" value="CoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51219">
        <property type="entry name" value="DPCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4043953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="274" mass="30477" checksum="36F85FB2444D25AF" modified="2024-10-02" version="1">MLLIGLTGSIATGKSTVSSLLSQPPYSLPVIDADLLARQVVEPGTPGYKAIVSYFGPSTPDLLLPSGDGMPDLGPQGHGRPLNRPALGRRVFGDDEQRKRDRKVLNGIVHPAVRRAMFKAVVGSYLRGCRAVVLDVPLLFESSLDRFCGTVVVVAVRDPKVQMERLRRRDPHLSVEDAQNRVGSQGDVREKARRCEARGEGRGVVVWNDGGREELAGEVRRVMGEIERCSPRWWSWLLWACPPAAAALAVWGFWRNVRINRAWEEQELRERAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PMT5</accession>
    <name>A0AAN6PMT5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_32241</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854325">
        <property type="protein sequence ID" value="KAK4043712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PMT5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045464">
        <property type="entry name" value="Hrt3/FBXO9_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12874:SF9">
        <property type="entry name" value="F-BOX ONLY PROTEIN 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12874">
        <property type="entry name" value="F-BOX ONLY PROTEIN 48-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19270">
        <property type="entry name" value="FBO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box" evidence="3">
        <location>
            <begin position="209"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="146"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="103"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4043712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="530" mass="58807" checksum="06B113BDC7354F45" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PND5</accession>
    <name>A0AAN6PND5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_33663</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854343">
        <property type="protein sequence ID" value="KAK4042314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PND5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026749">
        <property type="entry name" value="Tmem135"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12459:SF15">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12459">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 135-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="361"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4042314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="494" mass="54319" checksum="D4741F741EA4CB80" modified="2024-10-02" version="1">MAAATSPRPRWDSAIAPILRPLVRAYLFGYASAAGPRLLTLVLQHAARRRRDSKQTTTARDTPPAEPFLPALQRILLGPLGAQSFPAFCAALVGGTTFLELPLRSFFDRHAGNISAVARRRLSRWLASFIAAWLSLRLLQSKQTPSFTDVTAESGPDGVPQTIHYAGRTLDLTLLAVTRALDVIGGELWHRRKLRREAAGTWTRLDRAAARLADPALFALSSGLIMWTWIYLPSRLPRAYNKWISSAAAVDARLIAALQRCRDRTLLYGHDTNQAPLLGAMCADYGWPREWGDPARSVPFPCEMVHMGSGPSCEYHALARFAQSFRWALASYLPLSLLLAARSTTTSTTSRHARIRALRRAVLSAARSSAFLGAFITLFYYGVCLARTRVGPHVLGKDAAARQKIDGGYCVAAGCALCGWSILLENAGRRKDIALFVAPRALATLFPRRYGLEKQWRETLAFAASVAVVLTCFKENRGRVRGVMGGVLGFVFRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PNF9</accession>
    <name>A0AAN6PNF9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ethanolamine kinase</fullName>
            <ecNumber evidence="3">2.7.1.82</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_44840</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the choline/ethanolamine kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.82" evidence="3"/>
    <dbReference type="EMBL" id="MU854346">
        <property type="protein sequence ID" value="KAK4042061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PNF9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004305">
        <property type="term" value="F:ethanolamine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05157">
        <property type="entry name" value="ETNK_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603">
        <property type="entry name" value="CHOLINE/ETHANOALAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603:SF66">
        <property type="entry name" value="ETHANOLAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01633">
        <property type="entry name" value="Choline_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4042061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="439" mass="49372" checksum="411F86410B2F5A42" modified="2024-10-02" version="1">MAVGRENGIRCNGELDGDDHKIRYIPLSYDSATSEESALRIVLSIRPDWQSPDSNVEFVRFTDGITNTLLKAVNKRPGLSKNDVDKEAILLRAYGHGTDVIIDRHRETQNHELLMRHGLAPELLARFENGMMYRFIQGAVTQPEDLRKPDIYRAVARRLAEWHAVVPCISARTGHSRKNSRVDGFAGPALDSDLGDAEFQLALDGVAPGKPPPNVWTVMQKWIFALPTDTEPQRARQAELQHELKRLVSELSQRPGLGVNGLVFAHCDLLSGNVIVVPKSQLAGDKSTEPTVAFIDYEYATPSPAAFDLANHFAEWGGFDCDFSVLPTRAQRREFIAEYVDSYFSLLEKQRPGAAATVDKAAEVKQLHEEVDHYRGVPGFYWGIWALIQATISDIDFDYASYAETRLGEYYAWRAEVTGARKKSGQEMPLRERRWAQEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PNP0</accession>
    <name>A0AAN6PNP0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_34096</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854350">
        <property type="protein sequence ID" value="KAK4041845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PNP0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="279"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4041845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="409" mass="45985" checksum="17D7672B25FFD6C7" modified="2024-10-02" version="1">MSRLYRPFRTLFGSAKIASRLSGGQTVRIERVKFKKRRSATRVLSTVIKSALVFQLLMWAIPPTPADTTKESEGRDGDKEAPTFIPLPLTTKKLPPQPYSKSDPEWQEFIRISNDRQLQHRIRHYIAEYVLEIATQHPVAIARIGKEVRLGRYWMGFEYPRMAPPVYERTGILITDDAVALVTRPHDPWIAKQLDRALNPRPLALGVWAFGTAMVKQTALDVAKYFGFASETPSSAPARPTLGPPPPLPSDPRAQVQNSLEQIRQQATRRPEEVDNRGSMSSSASAPSASPSKPIGVGKPAPDQNNQETSKQKPSAEDLVLSLAGSEPWKKLKQTYDRERRPFRADPPRGSIYVSGLVELETPKAWVVFDVTMWYDPKTKARAPFTTSLYLRRITPKYGLRPNELPPTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2025-10-08" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PPK2</accession>
    <name>A0AAN6PPK2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_31054</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854316">
        <property type="protein sequence ID" value="KAK4044868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056416">
        <property type="entry name" value="DH_2_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056222">
        <property type="entry name" value="PH_23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056223">
        <property type="entry name" value="PH_24"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24340">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24344">
        <property type="entry name" value="PH_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24345">
        <property type="entry name" value="PH_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DBL homology" evidence="3">
        <location>
            <begin position="903"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="1106"/>
            <end position="1247"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="5">
        <location>
            <begin position="1478"/>
            <end position="1630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="162"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="543"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="601"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="881"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1247"/>
            <end position="1484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1635"/>
            <end position="1679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1693"/>
            <end position="1762"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="83"/>
            <end position="114"/>
        </location>
    </feature>
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        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="174"/>
            <end position="186"/>
        </location>
    </feature>
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        <location>
            <begin position="194"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="247"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="271"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="281"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="366"/>
            <end position="391"/>
        </location>
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        <location>
            <begin position="416"/>
            <end position="435"/>
        </location>
    </feature>
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        <location>
            <begin position="461"/>
            <end position="473"/>
        </location>
    </feature>
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        <location>
            <begin position="488"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="621"/>
            <end position="633"/>
        </location>
    </feature>
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        <location>
            <begin position="666"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="677"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="719"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="746"/>
            <end position="762"/>
        </location>
    </feature>
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        <location>
            <begin position="773"/>
            <end position="794"/>
        </location>
    </feature>
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        <location>
            <begin position="815"/>
            <end position="825"/>
        </location>
    </feature>
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        <location>
            <begin position="833"/>
            <end position="845"/>
        </location>
    </feature>
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        <location>
            <begin position="883"/>
            <end position="903"/>
        </location>
    </feature>
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        <location>
            <begin position="1312"/>
            <end position="1335"/>
        </location>
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        <location>
            <begin position="1405"/>
            <end position="1415"/>
        </location>
    </feature>
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        <location>
            <begin position="1456"/>
            <end position="1471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1472"/>
            <end position="1484"/>
        </location>
    </feature>
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        <location>
            <begin position="1641"/>
            <end position="1656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1749"/>
            <end position="1762"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4044868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1918" mass="209958" checksum="24A54889AEC8C611" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PPX5</accession>
    <name>A0AAN6PPX5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Hexose transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_33062</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854335">
        <property type="protein sequence ID" value="KAK4042811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PPX5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000594">
        <property type="entry name" value="MFS alpha-glucoside transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF2">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="333"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="356"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="384"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="412"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="450"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="485"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="64"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4042811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="546" mass="60097" checksum="791367CD0AA690B1" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PQJ7</accession>
    <name>A0AAN6PQJ7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">26S proteasome subunit RPN7-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_32782</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854331">
        <property type="protein sequence ID" value="KAK4043141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PQJ7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005838">
        <property type="term" value="C:proteasome regulatory particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.570:FF:000013">
        <property type="entry name" value="Proteasome regulatory particle subunit (RpnG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.570:FF:000021">
        <property type="entry name" value="Putative proteasome regulatory particle subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019585">
        <property type="entry name" value="Rpn7/CSN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045135">
        <property type="entry name" value="Rpn7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049549">
        <property type="entry name" value="RPN7_PSMD6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145">
        <property type="entry name" value="26S PROTESOME SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10602">
        <property type="entry name" value="RPN7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21154">
        <property type="entry name" value="RPN7_PSMD6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="3">
        <location>
            <begin position="229"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="106"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4043141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="490" mass="54128" checksum="C329BF5FA86C3F42" modified="2024-10-02" version="1">MGSDLQYAKWPLLPLAQHVFSLTNPYAPKTAQQAAAKQLQDAISEHKMAPFYRYLAHPIDGILNAVGESSANVPGKPTSRKSSLVGMIATRSPTASINLPWDEALYQSLQAENDKELEQFQKEEDDAVEQAGETEIQAARGKRAEFWARVGDKEKAIAAYEDVFEKTGILGTKIDLVLAIIRMGLFYGDKQLVKKHVERAKALVESGGDWDRRNRLKAYEGLYLLTARSYNLAAPLLLDSLSTFTSYELCTYSNLVIYAVLAGSVSLKRVDFKSKVVDAPEIKAILGDGEDKLLALTGAISAGPGADAEMQDAGTTPSAAKITAVNLTTLGSSVDQPEAEMAVDFGPLAQLVSSLYNGRYKLFFQALALVEEQFLTQDRYLHEHKGWFIREMRLRAYQQLLQSYRVVGLDSMASDFGVTVDFLDRDLAKFIAAGRIPCTIDRVAGQGVIETNRPDDKNKQYQDVVRQGDQLITKLQKYGQAVRLRGSERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PR82</accession>
    <name>A0AAN6PR82_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_12717</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854324">
        <property type="protein sequence ID" value="KAK4043799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PR82"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039965">
        <property type="entry name" value="C3H7.08c"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40466">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40466:SF1">
        <property type="entry name" value="FUNGAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4043799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="128" mass="13886" checksum="3E8FEC8A2F9D73C1" modified="2024-10-02" version="1">MASIIARRAFSTTARRLATGEEALRTESKKNPEIMILGGVMVCAFAGAGYYFGRSPTKSTSESPVPLAKNSMPWETDATHGKYQYHPGGDSSAPPKDAPSAVNVVVVPDVELPKRLHDKYNKWGKDGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PRA2</accession>
    <name>A0AAN6PRA2_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_32656</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854330">
        <property type="protein sequence ID" value="KAK4043165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PRA2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00275">
        <property type="entry name" value="C2_PLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000220">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF82">
        <property type="entry name" value="PHOSPHOINOSITIDE PHOSPHOLIPASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="12"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4043165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="178" mass="19454" checksum="69D0B45D321F812F" modified="2024-10-02" version="1">MTKPLPPTTTTTPSTTTPNPQALAVKHYTMHLTIQILAAQSLPLPPGDDSPSSFRPYVKVEVHVEEPGERHGSADSAVPADGKAKEGEYKAKTKSMKGCEPDFKGQELRFEGIPGVVPELSFVRFLVRDDEVGRDSLAAWACVRVDRLREGYRFVHLVDAEGVETEGAVLVRVGMRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PRS2</accession>
    <name>A0AAN6PRS2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_30969</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat PWP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854316">
        <property type="protein sequence ID" value="KAK4044788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PRS2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000470">
        <property type="entry name" value="Periodic tryptophan protein 2 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001292">
        <property type="entry name" value="Periodic tryptophan protein 2 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027145">
        <property type="entry name" value="PWP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007148">
        <property type="entry name" value="SSU_processome_Utp12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19858:SF0">
        <property type="entry name" value="PERIODIC TRYPTOPHAN PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19858">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04003">
        <property type="entry name" value="Utp12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
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            <end position="845"/>
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    </evidence>
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        <source>
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        </source>
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</entry>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </reference>
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        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        </source>
    </evidence>
    <sequence length="162" mass="15587" checksum="C891E57362D6D3CE" modified="2024-10-02" version="1">MDKAAKKLAEVASIPRHMVANGPGLKAVTATAADMQPLAAAVMEVVTDAAKQAAKEVTQYASDHPYVTACIVGGVLVALAPQAATVPMLNAVGFSAEGVVATAAAHSNIGNAVAGSVFSTLQSAGAGGAGAAVADGAASMAGTAVAGAAAGAKFWARSKAKL</sequence>
</entry>
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        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
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                <person name="Bonometti L."/>
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                <person name="Cros-Aarteil S."/>
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                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="PROTEIN DIAPHANOUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45691:SF6">
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="598" mass="65358" checksum="C78462D4AF3F8B1B" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SL76</accession>
    <name>A0AAN6SL76_9PEZI</name>
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        <name evidence="3" type="ORF">C8A01DRAFT_41783</name>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
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                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
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                <person name="Chen C."/>
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                <person name="Daum C."/>
                <person name="Ng V."/>
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                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854704">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="GPI INOSITOL-DEACYLASE"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4031769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="302" mass="33741" checksum="172CA4899D549659" modified="2024-10-02" version="1">MLASLAKQLCARRPVLPQLMESLYEYKERGERPDAKTLEAALMAAMGGFSTVHIVIDAMDECPVLKGERRRLLDTICRTATAAPATLHMLCTSRKEADIGAFDALRNLSSVVLIRKALSELPVGLDATYDRLLQGIDPKFESQVASSLKWLALSSKAFRIEELAEIFILRPDRTVVLDKVERLFKPQDVLKYLSGLVLAYDIPQYPPTDSHTQVRLPHFSIREYLVSDRITKGPAARSAFSEAEAHLHIARSCLAYHLQIGDMDDDEANKCGPFLLGDYISSAWPVHLEVVPRELWPPKVAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SLB6</accession>
    <name>A0AAN6SLB6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">protein-ribulosamine 3-kinase</fullName>
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        <name evidence="3" type="ORF">C8A01DRAFT_51403</name>
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        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>N(6)-D-ribulosyl-L-lysyl-[protein] + ATP = N(6)-(3-O-phospho-D-ribulosyl)-L-lysyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48432"/>
            <dbReference type="Rhea" id="RHEA-COMP:12103"/>
            <dbReference type="Rhea" id="RHEA-COMP:12104"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:90418"/>
            <dbReference type="ChEBI" id="CHEBI:90420"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.172"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:48433"/>
        </physiologicalReaction>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.172" evidence="1"/>
    <dbReference type="EMBL" id="MU854763">
        <property type="protein sequence ID" value="KAK4031558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SLB6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102193">
        <property type="term" value="F:protein-ribulosamine 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016477">
        <property type="entry name" value="Fructo-/Ketosamine-3-kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12149">
        <property type="entry name" value="FRUCTOSAMINE 3 KINASE-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12149:SF8">
        <property type="entry name" value="PROTEIN-RIBULOSAMINE 3-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03881">
        <property type="entry name" value="Fructosamin_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00048655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4031558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="325" mass="37020" checksum="99CD44F1AF0EDAC9" modified="2024-10-02" version="1">MVRIDPEFVAATLPDDEKYEGTEVDANVLQALPSGITIKWSSTRGASFRAILSKLDTILEDGQEKSYFMKVYTLAAVVPGNVPKAVAYGVCASDPNRAFFLAEFRDMTDELPDIMDLVSIVAKIHQQPSLNEKFGFNVMTFSGKHASDNTWCDTWEEFFTRAMRDTMEAKLAIHGPDEELQELSEKILTKVIPRLIRPMETEGRRIEPVLLHGDLWHGNVSIDNETKEPVLYDPCCFYGHNDYDFGMWRASRCRMNRAHVQAYFKLAKITEPSEDQDDRQALYAMQRMRELSKEEMRRLVAKYGGGYEGYLASKEVSPLEASTKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SLD1</accession>
    <name>A0AAN6SLD1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_41978</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854757">
        <property type="protein sequence ID" value="KAK4031572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SLD1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4031572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="201" mass="22730" checksum="6E6FA33793DA4BBE" modified="2024-10-02" version="1">MATEVGDRAFHSAQSLYLKLLGAFPDYVADFKAKLQSWQEAISPSSDPSTWSSVPEFDALLALGPKAVPLALRHLSLAEGDATAAFLYNKLEHDPEYLVDNADPTRHVAAILEKNFKRNRVFGELVKLGPPVIPQLMLKYKPRNGPTFSYELLHAILWGYTTEQQTVSLVDQYNMWDDWFQKRNHNEAPHYARPSQGVSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SLE0</accession>
    <name>A0AAN6SLE0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Kinesin light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_51351</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854743">
        <property type="protein sequence ID" value="KAK4031633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SLE0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4031633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="143" mass="16206" checksum="7943D924B029BA43" modified="2024-10-02" version="1">MFSARSIPIRFGGRYDEDEKISVEVLALRRDVLGEKYPDTIRSMANLAAIYHAQGRYDEDEKISVEVLALQRDVLGEKHPNTLQAMYDLAVTWNSRQRRPEALAMIQECFQLQCSVLGRTHPSTGGSLRVLNSWGRTGKRALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SLE3</accession>
    <name>A0AAN6SLE3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_21200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854746">
        <property type="protein sequence ID" value="KAK4031617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SLE3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4031617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="357" mass="41286" checksum="D1ACE3D81CA9731F" modified="2024-10-02" version="1">MPCIDCTNAKYWDRSPFGSAQSHAETHHPDWRIRYLVVHPRDSAIFGLLHACRESRGFWLTHYHRVPRYIDIRKQFVPMKPRDSEIQGPYNIRFDIPFHSDLIDRDPDPMFRTWDAFLGLDYHLIQHVGLRTWDLILEFAAAMHEIWPPALPSLGSVSLITLGPDPGLKGRSRPGWVQMGPRVPQRAFDFELRDISATQLERHPLFRDRIISKYGTTGPPEAPVRDLVLLAKAWLWHIANRELEGPWNCMIGARPDYMTVVPRWHRCPIYDGSQPCIPHTRQEILDWEPPYELTAKFFCERSWLADLESVGVFDDDRTGAGDFAAFFRLRDEEVDRPALFVAKAIVDGILDGTVTPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SLY3</accession>
    <name>A0AAN6SLY3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Signal recognition particle 54 kDa protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">C8A01DRAFT_40269</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Signal-recognition-particle (SRP) assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum (ER) membrane. SRP is required for the cotranslational protein translocation for ER import and preferentially recognizes strongly hydrophobic signal sequences. It is involved in targeting the nascent chain-ribosome (RNC) complex to the ER and is proposed to participate in the arrest of nascent chain elongation during membrane targeting. SRP54 binds to the signal sequence of presecretory protein when they emerge from the ribosomes. SRP54 interacts with the scR1 RNA and mediates the association of the resulting SRP-RNC complex with the signal recognition particle receptor (SR) via its alpha subunit SRP101. Both, SRP54 and SRP101, are locked in their GTP bound forms in the SRP-RNC-SR complex, which dissociates upon transferring the signal sequence to the protein-conducting channel (translocon). After signal sequence transfer, SRP54 and SRP101 act as reciprocal GTPase-activating proteins (GAPs), thereby resolving their association.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">Fungal signal recognition particle consists of a 7S RNA molecule (scR1) and at least six protein subunits: srp72, srp68, srp54, sec65, srp21 and srp14.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 13">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="13">The M domain binds the 7SL RNA and the signal sequence of presecretory proteins.</text>
    </comment>
    <comment type="domain">
        <text evidence="13">The NG domain, also named G domain, is a special guanosine triphosphatase (GTPase) domain, which binds GTP and forms a guanosine 5'-triphosphate (GTP)-dependent complex with a homologous NG domain in the SRP receptor subunit srp101. The two NG domains undergo cooperative rearrangements upon their assembly, which culminate in the reciprocal activation of the GTPase activity of one another. SRP receptor compaction upon binding with cargo-loaded SRP and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the GTP-binding SRP family. SRP54 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854541">
        <property type="protein sequence ID" value="KAK4033266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SLY3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030942">
        <property type="term" value="F:endoplasmic reticulum signal peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006616">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17875">
        <property type="entry name" value="SRP54_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.30:FF:000003">
        <property type="entry name" value="Signal recognition particle 54 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000022">
        <property type="entry name" value="Signal recognition particle 54 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="entry name" value="Signal recognition particle SRP54, nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.30">
        <property type="entry name" value="Signal recognition particle, SRP54 subunit, M-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00306">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036891">
        <property type="entry name" value="Signal_recog_part_SRP54_M_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004125">
        <property type="entry name" value="Signal_recog_particle_SRP54_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022941">
        <property type="entry name" value="SRP54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006325">
        <property type="entry name" value="SRP54_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01425">
        <property type="entry name" value="SRP54_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 54K PROTEIN SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564:SF5">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02978">
        <property type="entry name" value="SRP_SPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47446">
        <property type="entry name" value="Signal peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 13" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8 13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10 13" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="SRP54-type proteins GTP-binding" evidence="14">
        <location>
            <begin position="279"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU364034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK4033266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="531" mass="57567" checksum="473E6F25F6FD4CBF" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SLZ1</accession>
    <name>A0AAN6SLZ1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ClpP/crotonase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_20699</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Siderophore biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854635">
        <property type="protein sequence ID" value="KAK4032203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SLZ1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000074">
        <property type="entry name" value="Enoyl-CoA hydratase (AFU_orthologue AFUA_2G10650)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF158">
        <property type="entry name" value="ENOYL-COA HYDRATASE (AFU_ORTHOLOGUE AFUA_2G10650)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4032203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="290" mass="31050" checksum="A004E40E9E11DF5A" modified="2024-10-02" version="1">MSPSTTLSSLPPPPPVPNTHLSLPSPHVLLVTLARPAALNAIPSAQHPAMAALWAWYDAQPQLRCAVLTGGDGRAFCAGADLREWDVTHQTADQEKGGEAARFRERWTQEGFGGLSNRAGKKPVVAAVNGLCFGGGMEMVVNCDLVVADGKRARFGLPEVGKGVIAVAGALPRLVRTVGRQRAAEMALLGRTGYTAEQMREWGVVNFVVGEGRAVEEAIKVAEEIAGNSPDAVIVSREGLRLGWEAMGPQMGTEVLDRGMYGRMDGGENMKEGLRSFVEKRKPVWKDSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SMP5</accession>
    <name>A0AAN6SMP5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_19067</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854496">
        <property type="protein sequence ID" value="KAK4034076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SMP5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4034076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="192" mass="20905" checksum="A75E5D56BB3D8337" modified="2024-10-02" version="1">MPAGEMQGTHDFEELLRHGVEKHLLGQSAADVAGRKRRRDGDMDGEYTAPAAKRTKGDGDGKCPASAARRTESDGDRECPAPPAKRKRAARHNVAYKKELAPIVIYDADSDLCMDVIICASTVDEQQPCHLTKNHMGSSAALDPDFLGHVDPALLAPCRPASAAHHTAAVFSDHQTQEALRRPRRRRGRCHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SMU4</accession>
    <name>A0AAN6SMU4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">C8A01DRAFT_40639</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="MU854564">
        <property type="protein sequence ID" value="KAK4032925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SMU4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000306">
        <property type="entry name" value="IKS protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000699">
        <property type="entry name" value="Probable serine/threonine-protein kinase iksA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF138">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE IKS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="143"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="447"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="486"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="597"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAK4032925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="682" mass="75322" checksum="EE053F04F649AE63" modified="2024-10-02" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SND5</accession>
    <name>A0AAN6SND5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_18473</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854466">
        <property type="protein sequence ID" value="KAK4034781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SND5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051430">
        <property type="entry name" value="Fungal_TF_Env_Response"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944:SF131">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="44"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="85"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="196"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="96"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="167"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4034781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="833" mass="91301" checksum="8E1657E9C22B1CDE" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SNG3</accession>
    <name>A0AAN6SNG3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_19323</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854510">
        <property type="protein sequence ID" value="KAK4033792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SNG3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08276">
        <property type="entry name" value="MDR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052711">
        <property type="entry name" value="Zinc_ADH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C1773.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="16"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4033792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="344" mass="36651" checksum="A49655728FDE2F0C" modified="2024-10-02" version="1">MSTPKTTKAWTVEGNGGFECLKFDKERVLPELSDNEVLVKFHAASLNYRDISIPMGQFPFPVAPNVVPGSDGAGEVVAVGSKVTRFEQGSKVVTLFNQAHYGGPLTLKVLGTSLGGAVDGTLRQYGIFNENGLVDMPKNLSYLEAGTLSCSALTAWNALYGLKPVLPGDWVLTQGTGGVSISALQFAKAAGARVIATTSSAAKAETLKKLGADHVINYKETPNWGDEAKKVTGGVQHVIEVGGATTVTQSLKAVGIGGVVTIIGWIGGEGEKGPDFPQILSSMAVVRGIVVGSREQLEAMIRTIEAFDIKPVLDQQVFKLEDLKEAYKYQWDQKHFGKVAIKIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SP49</accession>
    <name>A0AAN6SP49_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DUF676 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_49201</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854481">
        <property type="protein sequence ID" value="KAK4034393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SP49"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052374">
        <property type="entry name" value="SERAC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182:SF2">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4034393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="331" mass="36151" checksum="53F7F6F84F85DEE9" modified="2024-10-02" version="1">MSLKHLLNLVHPGHEEFPSGIKGLHAPADAVVDVVFIHDLNGDREQSWTAQGASEPWPKTLLPAKLPTARVLTFGYDVMHPTKWRGVVSQNRIGDHAGNLLASLASLREADGTNERPILFVCHGLGGLVCEDALVMSKQKPEPYLRAIQQSTRGIAFLGTPHQGSNIADWYERWGRRLGHFRPTNLDIVSVLHRESEVLARIQNSFHTMLKARTVQALPPIEIACFYEELPLPGIGLAVSMQSAVCPGCGVPIGIHANHTDMTKFVGAHDPGFVALSRELGRWVREISRTAMQNAKPPSESFLKGGQGAARAWGPGGWQICHFSGVLLFGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SP93</accession>
    <name>A0AAN6SP93_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">U4/U6 snRNA-associated-splicing factor PRP24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">C8A01DRAFT_18718</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as a recycling factor of the spliceosome, a machinery that forms on each precursor-messenger RNA (pre-mRNA) and catalyzes the removal of introns. Chaperones the re-annealing of U4 and U6 snRNAs (small nuclear RNAs) released from previous rounds of splicing, an initial step in reforming the U4/U6-U5 tri-snRNP (small nuclear ribonucleoprotein) that can reassemble into another spliceosome complex; this step involves binding U6 and facilitating the unwinding of the U6 internal stem loop, followed by base-pairing of U6 to U4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAK4034485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SP93"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="U4/U6 snRNA-associated-splicing factor PRP24"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034397">
        <property type="entry name" value="Prp24_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031766">
        <property type="entry name" value="RRM_occluded"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10352">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16842">
        <property type="entry name" value="RRM_occluded"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="599"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="673"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="765"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="529"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="839"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1057"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="533"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="578"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="869"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1064"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1090"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1100"/>
            <end position="1122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00093374"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00093627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK4034485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1130" mass="123994" checksum="306FF57AF852578E" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SPT1</accession>
    <name>A0AAN6SPT1_9PEZI</name>
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        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_38415</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854454">
        <property type="protein sequence ID" value="KAK4035143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SPT1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="417"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="279"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="292"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
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            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
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            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="473"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="517"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="545"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="559"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="598"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="624"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4035143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="636" mass="68036" checksum="249AA91A3FA8C84E" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SPZ9</accession>
    <name>A0AAN6SPZ9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GTP-binding protein EsdC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_17828</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854442">
        <property type="protein sequence ID" value="KAK4038015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SPZ9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40625:SF2">
        <property type="entry name" value="GTP-BINDING PROTEIN ESDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40625">
        <property type="entry name" value="GTP-BINDING PROTEIN ESDC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4038015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="275" mass="29789" checksum="65E8467B5731A859" modified="2024-10-02" version="1">MSAIQLSFSLRVSSGVKTVHLLGSWDNYSGQLPLSKDKSSSKGTWKGTFRFQQATLQPGQRYWYYYIIDGYHVSHNPSEDSTVEPTTGRALNILDVPKAKSSSSSSSKSSSRKSTSSSKSRASVAGDIPKGRPLSVSQIKAPKPVSPNATRHILDNDFDEDELSSRFAATGIYEDDYYNEDIVTDFGAPGSPVSSVGSSLSYRSDSSASSSGYSTPASDCSSCTCERYGITRKGERVRLDCGGSRCSYDDSCSSSEDEAEYVERSSRRNGIVVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SQA9</accession>
    <name>A0AAN6SQA9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_37732</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854432">
        <property type="protein sequence ID" value="KAK4038345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SQA9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF42">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="24"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4038345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="350" mass="38251" checksum="4753A0A3BA07D02D" modified="2024-10-02" version="1">MTAVSDMAWSFGALMILSTLTIGLRIFVKHRRGRPIRKDDYTLAAAWVFLLTSLIFIMVAASQGYGQHLADLKSDPTEAVKLVGAAEFFAVSAGAIAKTSVAMTLLKVLKLRWQRSVTWWLAASVNIVIWGFAIFLWVIISQGRLVSICKEAGAVWRFAMFGAVWSALTDFAFSILPWPFVWKLHQQKAEKILLGLGMSCGIGSGVIAIVKITQMDCRNFEHDITHDSVALVIWTFAEPVAIIVAASVPILRKLFEKPAQAALERELMGARGGRGIPPSNSFPPTAGLGRQTNTWNVTSGPFDSSIALQTLGARDSILRTDALDIRIEEINPNAPQRAPDATQISKSESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SRG2</accession>
    <name>A0AAN6SRG2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_36550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854400">
        <property type="protein sequence ID" value="KAK4039426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SRG2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4039426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="79" mass="8802" checksum="4D962C916109A93A" modified="2024-10-02" version="1" fragment="single">SATGSLHHIRTAILNPKDAANSTADGKVGRRSPRTPVDNAKRDPRYNEHIDAVLLEARHLQRLSMLIHLTQAEKKDIVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SS06</accession>
    <name>A0AAN6SS06_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">C8A01DRAFT_46253</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854377">
        <property type="protein sequence ID" value="KAK4040447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SS06"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00747">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="9" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043041700" description="CFEM domain-containing protein" evidence="11">
        <location>
            <begin position="21"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="12">
        <location>
            <begin position="22"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="222"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="337"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="415"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="222"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="415"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="440"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="452"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="64"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK4040447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="498" mass="47821" checksum="E0F1B7A50A63D74B" modified="2024-10-02" version="1">MRSTTKAVAGFLLVTAGALAQNAGAATVTPAPSCGGDNPCAGQVSAVPTCATSCIESAASNLGCIGHDYSCHCAKYDAIQDSAIGCVLGACGLGEALKVPDAVGSLCSCVTASPTTPCTDEPSTSTSTIDMTTITTTTTKPKPTPTPACPEHECVAGCVNAVLPQFGCNELEDWNCYCTNFRKITSRAFACAWACTPNVYAAFNTPASQGCTCLLEECPASSSSSVESSSPSSSTTTTTPPEPPPSTPPPPPTPPPPPCPPPCAPSISAVPPCATACITNAASAGLACQCSSAEAIQASAAGCVVGACGLEGALKVVDAVGALCSCVAALPANTACGTTTPTAGATSSSSGSTRTGSGEETTSTGESGSGVVTETRTVEVTSLVCDDGDEGSASATATATATVSCVAGCNGGGDGGEDGGDGDDEDGSGSGSSPSRSPSGGPGGGNGGNSGGSSSSSRAGSGSTNTPKPPVETAGSSNLVRAWAGCLAGVVAVAAALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6ST14</accession>
    <name>A0AAN6ST14_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Gylcosyl hydrolase 115 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_34746</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854361">
        <property type="protein sequence ID" value="KAK4041225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6ST14"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="entry name" value="Chitobiase/beta-hexosaminidase domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.520">
        <property type="entry name" value="Glycosyl hydrolase family 115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031924">
        <property type="entry name" value="GH115"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041437">
        <property type="entry name" value="GH115_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042301">
        <property type="entry name" value="GH115_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37842">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37842:SF2">
        <property type="entry name" value="GYLCOSYL HYDROLASE 115 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17829">
        <property type="entry name" value="GH115_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15979">
        <property type="entry name" value="Glyco_hydro_115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042941917" description="Gylcosyl hydrolase 115 C-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="21"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="domain" description="Gylcosyl hydrolase 115 C-terminal" evidence="4">
        <location>
            <begin position="802"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="993"/>
            <end position="1013"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4041225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1013" mass="112457" checksum="3512BA0ACED4AB87" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6STG1</accession>
    <name>A0AAN6STG1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_13891</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854340">
        <property type="protein sequence ID" value="KAK4042514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6STG1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01831">
        <property type="entry name" value="Endoglucanase_E_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037461">
        <property type="entry name" value="CtCE2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052762">
        <property type="entry name" value="PCW_deacetylase/CE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37834:SF2">
        <property type="entry name" value="ESTERASE, SGNH HYDROLASE-TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37834">
        <property type="entry name" value="GDSL-LIKE LIPASE/ACYLHYDROLASE DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_2G00620)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042834092" evidence="1">
        <location>
            <begin position="21"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="2">
        <location>
            <begin position="174"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4042514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="433" mass="47942" checksum="B08041353100102E" modified="2024-10-02" version="1">MVSFSSLAVFGLAVVSRVSATILQNGQVRETNFPDTRIDPAAHSFRTYPADAAEISYKGRWDSNYVSWWSAPGIKFGYTGQTVAVSFGNLTDNGVLVGYRIGGLDWIFTNITAGATHLLVSPETPGSSETGPVNPWTFEMRVTNWAYGVQIEAVHVAAGEKLIKLPDFGRRIEVIGDSLASGMYTTYEGLSSWAYGLGAGLGNTEYSVTAYPGICAADQNCWGNPHGQVHQWFYTSDTSGRAAAMYGDNPEPWDFKKHPAADIVVINIGTNDQNQANNVSTDAYIDALTKIIQGVHGKWPKAQVVVMSLWLGFYQSGNTYLPNSPDGWVKEIYNMVKWFNSDAYLRNPTIYDGVTRKTSRTGKKAKPFVHYFNTSGIMQHNDIGPQWHPTDVGAIKVASHLQQFIRMTFDWDLYATGPEVFHETLYWNDQSGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6STY7</accession>
    <name>A0AAN6STY7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">methylmalonate-semialdehyde dehydrogenase (CoA acylating)</fullName>
            <ecNumber evidence="2">1.2.1.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_44077</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.27" evidence="2"/>
    <dbReference type="EMBL" id="MU854333">
        <property type="protein sequence ID" value="KAK4043009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6STY7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004491">
        <property type="term" value="F:methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006210">
        <property type="term" value="P:thymine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07085">
        <property type="entry name" value="ALDH_F6_MMSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000002">
        <property type="entry name" value="Methylmalonate-semialdehyde dehydrogenase (Acylating)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000003">
        <property type="entry name" value="Methylmalonate-semialdehyde dehydrogenase [acylating]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010061">
        <property type="entry name" value="MeMal-semiAld_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01722">
        <property type="entry name" value="MMSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43866">
        <property type="entry name" value="MALONATE-SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43866:SF3">
        <property type="entry name" value="METHYLMALONATE-SEMIALDEHYDE DEHYDROGENASE [ACYLATING], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="6">
        <location>
            <begin position="95"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4043009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="582" mass="61985" checksum="43CB325161D6CE8C" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6STZ5</accession>
    <name>A0AAN6STZ5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Tubulin alpha chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">C8A01DRAFT_33696</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 15">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4 15">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the tubulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854344">
        <property type="protein sequence ID" value="KAK4042200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6STZ5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02186">
        <property type="entry name" value="alpha_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000005">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000006">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000011">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11 15" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="16">
        <location>
            <begin position="50"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="17">
        <location>
            <begin position="249"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAK4042200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="456" mass="50567" checksum="4799A40E3D90BDC3" modified="2024-10-02" version="1">MRGEILHVHLGQAGAQLGNSAWELYLLEHGLGVDGCPDPNAKDIADGVSYETFFTETSNGKYVPRSIFVDLDPSPIDEIRTGTYRQLFHPELLISGKEDAANNYARGHYTIGKEMIDSVIDRIRRVADNCHSLQGFLVFHSFGGGTGSGFGALLLERLSTDYAKKCKLEFTVYPAPRLSSAVVEPYNAVLSTHSTIENSDCTFLVDNEAVFDICRRNLDIPRPSYEHLNRLIAQVVSSITSSLRFDGALNVDLNEFQTNLVPYPRIHYPLISYAPVISAAKSAHESFKVSELTFQCFEPNNQMVVCDPRKGKYMAVALLYRGDVVHRDCSAAVAQLKAKSSFNLVEWCPTGFKIGINYQKPVAVPTASPQDGGLAAVDRSVSMLSNTTAIAEAWSRLDRKFDLMYSKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVAADSTYEGDEGEAEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SU53</accession>
    <name>A0AAN6SU53_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Glucose-6-phosphate 1-epimerase</fullName>
            <ecNumber evidence="3 5">5.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_33728</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the interconversion between the alpha and beta anomers from at least three hexose 6-phosphate sugars (Glc6P, Gal6P, and Man6P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose 6-phosphate = beta-D-glucose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:16249"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="ChEBI" id="CHEBI:58247"/>
            <dbReference type="EC" id="5.1.3.15"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the glucose-6-phosphate 1-epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.15" evidence="3 5"/>
    <dbReference type="EMBL" id="MU854344">
        <property type="protein sequence ID" value="KAK4042231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SU53"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047938">
        <property type="term" value="F:glucose-6-phosphate 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09020">
        <property type="entry name" value="D-hex-6-P-epi_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025532">
        <property type="entry name" value="G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11122">
        <property type="entry name" value="APOSPORY-ASSOCIATED PROTEIN C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11122:SF13">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE 1-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016020">
        <property type="entry name" value="PHexose_mutarotase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="297"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR016020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR016020-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR016020-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4042231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="323" mass="34556" checksum="F54C9E2A00B4C05B" modified="2024-10-02" version="1">MVDRANKPKTLSSTPSLPPQASVTFSEDNSRVTAELPTGESVEVLLYGATVLSWKDAAGDEKLWLSEAAKLDGSRAVRGGIPVVFPVFGTAPDHPQTKSLPQHGFARTSRWEFLGKSTSESMVGRAANELTVKLDFGLSSAAPGLDPTAAASWPFKFNLIYSVTLNRESLTTSIVATNDGAAPFDCQVLMHTYLRVKDITTVEITGLANAPYHDKVDAANPSKTQPASGPLTISAETDRVYTPVEDAVTVTEGGKPKFRVTRDNLSNVVVWNPWTEKAQGIADFAPKDGFRQMLCVEPGAVGAWQSVEGGDAFEGAQTITLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SUA7</accession>
    <name>A0AAN6SUA7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SGNH hydrolase-type esterase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_13831</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854339">
        <property type="protein sequence ID" value="KAK4042530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SUA7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01830">
        <property type="entry name" value="XynE_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053140">
        <property type="entry name" value="GDSL_Rv0518-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43784:SF3">
        <property type="entry name" value="GDSL FAMILY LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43784">
        <property type="entry name" value="GDSL-LIKE LIPASE/ACYLHYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G00820)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043010746" evidence="1">
        <location>
            <begin position="26"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="2">
        <location>
            <begin position="216"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4042530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="430" mass="46150" checksum="85B3E42C87CD68C0" modified="2024-10-02" version="1">MSHTFGLRRLLGLALSATCITVATCHDQWVDIWASMPQQVEPYNLPNAPYNGTDGVFQNTTIRQTIYLTQDASTIRLQFSNALGGSDLPITAATIALPANGTAGSPAIRPDTLQHLTFSGSRSFAIPNGALAVSDPIRFPVKAQASLTITVYLAAGQSGHAITGHPGSRTSTWLTQGNLVTATNVTTDTTQRIDKWFLISSLQAWLPPTHSSLAIVGDSITDGRGSTTNQNDRWPDQLVARLQQSPSFRPISVANMAAGGNRILADGLGPNALGRIERDVLAHPRSVRYALIYEGVNDLGTAATDAASQTAVGDRVIQAYDQMITRLHAAGIAVFGGTITPMSGPGQAYGHPVREEQRQRVNAWIRTSGRFDAVVDFDKVVRDPKNGTMLRTEYDSGDYLHLNPAGYKAMAEAVDLRLFARFAGGVHSMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SUZ2</accession>
    <name>A0AAN6SUZ2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Pyruvate dehydrogenase complex protein X component, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_32725</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="5">Eukaryotic pyruvate dehydrogenase (PDH) complexes are organized as a core consisting of the oligomeric dihydrolipoamide acetyl-transferase (E2), around which are arranged multiple copies of pyruvate dehydrogenase (E1), dihydrolipoamide dehydrogenase (E3) and protein X (E3BP) bound by non-covalent bonds. The Chaetomium thermophilum PDH complex contains 60 E2 units, 12 E3BP units, about 20 E1 units, and 12 or more E3 units. The units are organized in 1 E2 60-mer, 4 E3BP trimers, about 20 E1 tetramers, and a maximum of 12 E3 dimers. The E3BP trimers are bound inside the icosahedral core with tetrahedral symmetry.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854330">
        <property type="protein sequence ID" value="KAK4043235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SUZ2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045254">
        <property type="term" value="C:pyruvate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004742">
        <property type="term" value="F:dihydrolipoyllysine-residue acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000010">
        <property type="entry name" value="Acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="entry name" value="E3-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045257">
        <property type="entry name" value="E2/Pdx1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151">
        <property type="entry name" value="DIHYDROLIPOAMIDE ACETYL/SUCCINYL-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151:SF82">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE COMPLEX PROTEIN X COMPONENT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="4 9" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="7">
        <location>
            <begin position="37"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="8">
        <location>
            <begin position="173"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="130"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="144"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00061729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4043235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="425" mass="44627" checksum="96216851ADB51B27" modified="2024-10-02" version="1">MASFAAACRMSARLATRKVQQDAAARGFRTSAAALAAQNFTMPALSPTMTEGNIAAWRVKEGEKFSAGDVLLEIETDKATMDVEAQEDGFLMKVMQGDGSKGVQVGTRIAVIAEEGDDISSLQIPADENPQATKAAEAPKTQTPATPEPESTPSAAPPKAAPKPGGKISRAYPLYPSVAQLLAENGIDKSAVSDITPTGPNGRLLKGDVLAFLGKINANTPAEISSRFEQASHLDLSNIKVAKAPEPTKPAKEAAPAPPPAPVKSLVTLPVSLSAVIEAQRKIQKSLGVFLPLSTFISRASEVANDELPLPANYQPTADELFNQVLGLDKVGPKVSRGAYIPQIAALPSASAFPARAAPAKKVDILDILASKPKPAAKKTVVLPGPSTGPNLFSLHVPKVEERRAKVFLERVKVVLETEPGRLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SV03</accession>
    <name>A0AAN6SV03_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal recognition particle 9 kDa protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_43754</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854329">
        <property type="protein sequence ID" value="KAK4043265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SV03"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039914">
        <property type="entry name" value="SRP9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039432">
        <property type="entry name" value="SRP9_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12834">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 9 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12834:SF12">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 9 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05486">
        <property type="entry name" value="SRP9-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRP9" evidence="2">
        <location>
            <begin position="6"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4043265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="189" mass="19823" checksum="D411395FD60EF0B5" modified="2024-10-02" version="1">MPYYAKSEDWLHQSALLLQARPSTTRITTRYHLKPARRVPKPKKSDPSQPTTTTQSTQPQQPSEGKGQEEGKPPRGRLILKTFDPCSGATLKYKTSKAAEVTRLIQMLGTLGRRMAGVNVADEAEDEVMADVSTPVVEGEGGVGVGSGVQTPTLGQTAGGGGGAAVGGKEQAQQQGGGGGKGKKKKGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SV39</accession>
    <name>A0AAN6SV39_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_13340</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854331">
        <property type="protein sequence ID" value="KAK4043163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SV39"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000125">
        <property type="entry name" value="Putative zinc finger protein 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002061">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000912">
        <property type="entry name" value="Zinc finger protein 660"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF20">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G10380)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="128"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="156"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="186"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="214"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="184"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="232"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="423"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="240"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="251"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="306"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="328"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4043163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="450" mass="47807" checksum="71B5A2905003A0D1" modified="2024-10-02" version="1">MSQSPSSAGAMGIGNVLNIKAEPGAQQPQHGTTPELQQQRPPQQLQQLQVERQNSPHGSEQSRYSGPMNASYPSPTAMAATPLPPVPSANMAPAPMVPHEMQQDLVPGIPPGGYQPVQAPSQGAPKQFPCSTCGKPFARRSDLARHERIHSGIRPHVCDYPGCGKQFIQRSALTVHSRVHTGEKPHRCERCGKPFSDSSSLARHRRIHSGKRPYKCPYADCQKTFTRRTTLTRHQNHHVGTVEDSARARAEALAQGASAAAAAAARNKSRSGSEQASNHHESPLTTPSPGQRPISMSPGAELAGMNNMQYLTNSIPPHLRGDVHVGSPSPTASSGYNNGMRPTSHPTGYAPPQTLEPSIEQPQQGPGSAVGSPHIGSVGWASPGPVGSPTQSPNGNGYVYPDPESYPSGTPIAQMFYNSAVAARRPGSTEPGNPSFDAKGRQGELWTNAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SV74</accession>
    <name>A0AAN6SV74_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NTF2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_13009</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854327">
        <property type="protein sequence ID" value="KAK4043475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SV74"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018222">
        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50177">
        <property type="entry name" value="NTF2_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTF2" evidence="1">
        <location>
            <begin position="16"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4043475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="187" mass="21439" checksum="76D6B50B26914500" modified="2024-10-02" version="1">MSANSHETNVRCSCEAAKSFVDWYYRQVNDAKSVSPGYVNGHAAYDRAGHPPADICINGLVVATPQEWEKLLEQQRQAPKQPDPNKRRVRYEVEGYDVHVINADYRFGAPQKMLDLHSPTDGVRMMMVLSVAGTVYFGTGRNKGDEYWEKQNFHDRFILVPNWDVIEKPGARHGRKYLIISHNYRAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SV78</accession>
    <name>A0AAN6SV78_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_13181</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854329">
        <property type="protein sequence ID" value="KAK4043283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SV78"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4043283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="157" mass="17317" checksum="CEFD041FDE3D02DF" modified="2024-10-02" version="1">MPSATTPRQIAALPPLQARDQIRARLTSLTDAIAAHPGMRPPTRHPTLYHIWDFAMRTNYILSELDNMAAGRALQYPEQIPDYSASGKGTPDPAQAWEHFSDAGCRCTLIELMLCHPNRAMMAAMGLQDMDFGEELKGKAREVVEAVKGLERSVLGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SVA3</accession>
    <name>A0AAN6SVA3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sds3-like-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_12889</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854326">
        <property type="protein sequence ID" value="KAK4043565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SVA3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013907">
        <property type="entry name" value="Sds3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21964">
        <property type="entry name" value="BREAST CANCER METASTASIS-SUPPRESSOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08598">
        <property type="entry name" value="Sds3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01401">
        <property type="entry name" value="Sds3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="208"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="315"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="506"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="226"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="548"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4043565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="559" mass="61878" checksum="3DE4287A84A44A0F" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P5P6</accession>
    <name>A0AAN6P5P6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Beta-lactamase superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_42258</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854916">
        <property type="protein sequence ID" value="KAK4031267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P5P6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050114">
        <property type="entry name" value="UPF0173_UPF0282_UlaG_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43546:SF7">
        <property type="entry name" value="METALLO-BETA-LACTAMASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43546">
        <property type="entry name" value="UPF0173 METAL-DEPENDENT HYDROLASE MJ1163-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="2">
        <location>
            <begin position="113"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4031267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="385" mass="42081" checksum="ED230724EF27C75E" modified="2024-10-02" version="1">MDTEQPPKPLRETNHPPLVLNPQKRTPFLKTATHHPSPEPILPIAHTKHHPRKPPTTTTTPQTTTTARPETPDSNSGSVYFIGTATTIISFAGLRLLTDPNFLHAGDHVHLGPGVTAQRLTNPAVPDLASLPPVDAVLLSHYHEDHFDREVEAQLSRDMPIVTTEHAKQCLTEKGEEPFRKVWGVGEFEGVFMPVGDGQDPDIGEGGAGEGRTKKKKPAVRVTGMPGKHVPPGPLAAINELLGAVPPTNGWLVELGWTKPTEGEEGFETGYRIYISGDTLMVDELKEIPRRLRGDKIDLMLVHLGGTTIPGPNMPLLMVTMDGAQGVQLMRLVDPDVTVPIHFDDYDVFCSPLDDFKKEVDAAGFGDKVVYLDRGDEFKFTIRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P5R8</accession>
    <name>A0AAN6P5R8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alpha-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_41301</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing (1-&gt;4)-linked alpha-D-glucose residues with release of alpha-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.20"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.20" evidence="3"/>
    <dbReference type="EMBL" id="MU854629">
        <property type="protein sequence ID" value="KAK4032266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P5R8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004558">
        <property type="term" value="F:alpha-1,4-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF165">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G06560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 31 N-terminal" evidence="7">
        <location>
            <begin position="41"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="6">
        <location>
            <begin position="257"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="8">
        <location>
            <begin position="622"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4032266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="852" mass="94174" checksum="539B3242626ECEB8" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P5U9</accession>
    <name>A0AAN6P5U9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_50875</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854624">
        <property type="protein sequence ID" value="KAK4032311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P5U9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF5">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="3">
        <location>
            <begin position="406"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="44"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="48"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4032311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1059" mass="117926" checksum="7D8CA00DB118F53C" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P5Z5</accession>
    <name>A0AAN6P5Z5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_50804</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854615">
        <property type="protein sequence ID" value="KAK4032386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P5Z5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4032386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="286" mass="31861" checksum="D3F0C748029433B8" modified="2024-10-02" version="1">MGFCDTIPSQGPHHRPGSSQAIKSESSVPPRRLAWAGNSRDQSLRPSFGLPLSSMAVSRRPRSSSKTGKYNSTTTSALEIAGLTKIDRMTSEEDIVKLFNLFVMYPVEVALLQIKLPAAYDLQLRGEVYPDEGRAVRVDIVLGIRGPETVETLAVMEMKNFGVIQDEMHSIMAAKVTSAREARKTTSKSPNLFRCNQPKLLLRQGAAYALRFKTRHVALCDWAVTLYLEFPELDKALLNQKKGSSAGRYVLMHAQTDPSTFHYALLAFFKRAVDEWLLAQTALNKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P610</accession>
    <name>A0AAN6P610_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_42153</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854832">
        <property type="protein sequence ID" value="KAK4031385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P610"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4031385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="216" mass="24459" checksum="C332D05F4C5E960A" modified="2024-10-02" version="1">MLVAASSNSSSNSSRKRKRDVVEEEDNKEVEEEEESDEGFCSKSSFYKKAPYTVNVVKEEDNEEVEEEEESDEGFYSKSLFYKKAPYAVNVVEEEDDKEVEEEEEAEYRCRKAELEPRLRGFRTIDEPVPIAPAAATNDAADGVTLASLVERVSYLTGAIRLLIEIFAEETAFYTDIESDSDSKAKGLVSRIDRREVYNLLEDTTTEIAAIATERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P6U1</accession>
    <name>A0AAN6P6U1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_20175</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854574">
        <property type="protein sequence ID" value="KAK4032808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P6U1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4032808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="588" mass="66667" checksum="C88E4412ED1B6A41" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P8K3</accession>
    <name>A0AAN6P8K3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutamate-5-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="2">1.2.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Glutamate-5-semialdehyde dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Glutamyl-gamma-semialdehyde dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">C8A01DRAFT_19358</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the NADPH dependent reduction of L-gamma-glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-glutamate 5-semialdehyde + phosphate + NADP(+) = L-glutamyl 5-phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19541"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="ChEBI" id="CHEBI:58274"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the gamma-glutamyl phosphate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.41" evidence="2"/>
    <dbReference type="EMBL" id="MU854512">
        <property type="protein sequence ID" value="KAK4033753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P8K3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004350">
        <property type="term" value="F:glutamate-5-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07079">
        <property type="entry name" value="ALDH_F18-19_ProA-GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000006">
        <property type="entry name" value="Gamma-glutamyl phosphate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00412">
        <property type="entry name" value="ProA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020593">
        <property type="entry name" value="G-glutamylP_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012134">
        <property type="entry name" value="Glu-5-SA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000965">
        <property type="entry name" value="GPR_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001221">
        <property type="entry name" value="PRK00197.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00407">
        <property type="entry name" value="proA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11063:SF8">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11063">
        <property type="entry name" value="GLUTAMATE SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000151">
        <property type="entry name" value="GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01223">
        <property type="entry name" value="PROA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="12">
        <location>
            <begin position="9"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00059423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00060997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00075718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00077451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAK4033753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="446" mass="46829" checksum="29361D691FDA2E49" modified="2024-10-02" version="1">MSLTNASPADAAQAAKSASHVLATLSAAARNEALTAIHAALTAARDDILAANARDLELARQAAADGKLSQSLVARLDLGKPGKWDDMLKGILDVRDLDDPVGRVTLRTRLDNGLDLERVTCPIGVLLIIFEARPEVIANIAALAVKSGNAAILKGGKESTESFVAISSVISAALEKSQVPNGAIQLVTTRDVIPQLLALDAHIDLVIPRGSNELVRYIKNNTRIPVLGHADGLCAIYLEQSADPSMAADVILDSKTGYPAACNSLETLLVQDTALSTLLPTVAAALAAKGVELRCDAQSKAALAGVPNLALADATDADFATEFLSLTLAVKTVSSLPEAITHINTHGSHHTDCILTASPEQAEQFMAAVDSAGVYWNASTRLADGTRYGFGTEVGISTNKIHSRGPVGLEGLMIYKYKIRGQGQVAAAYGEGEGKKRFLHQRLPLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P9G7</accession>
    <name>A0AAN6P9G7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_39340</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854490">
        <property type="protein sequence ID" value="KAK4034209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P9G7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF26">
        <property type="entry name" value="AXIAL BUDDING PATTERN PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042980112" description="Mid2 domain-containing protein" evidence="7">
        <location>
            <begin position="23"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="135"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="135"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4034209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="284" mass="30150" checksum="FD42A9D19EE4C254" modified="2024-10-02" version="1">MARLDALACVLALQPLFPLVYSQFLTPLTERQVFRVGEVQKIQYRTKLTEYTIAIWQQALAGGAANLGPVVVRATNGPEKEFDWLVQLSGFDLDVSNVFFFWLKEGGLENVGSTQVQSMASAYFNVTDEPLPSTSSSTAFSSTITSSSSSSSTSSSSSSSTSSTLSTASPTAAANPLTATTNQGETTASNTSSESSEGGGLPVAAQAGIAVGAAIVGLTAIVCGILWFRYLRKQQRMLVKLQQQLYSQPPDAADMEMWKLQIPPGAAQNYPFGLGHDTRPAELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P9M4</accession>
    <name>A0AAN6P9M4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7730 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_40156</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854534">
        <property type="protein sequence ID" value="KAK4033367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P9M4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056632">
        <property type="entry name" value="DUF7730"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF2">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24864">
        <property type="entry name" value="DUF7730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7730" evidence="2">
        <location>
            <begin position="37"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4033367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="266" mass="29706" checksum="2C8289BEBF36A69F" modified="2024-10-02" version="1">MDDSTIEIPNSSSSEPVALSASAPTPTLPDTPGHFRFMRLPAELRLMVYRESLVPVQQIHLNCSTPRKFTCTSGASDRHPDICTGLLRVCHQITAEALPVLYGENSFVFLAHDLYRKAARCRAFSDANLLLLRTLRIVHPCKWDHYSSPWRPLAPQPAAPPNPDFWRAILGNLDSLTVVISIRCVGDEARDLTDDVANHAENNPNAARPVKAAMRFYDAGLPPSLVVHRRVLCDKFGDGSSHTFEKTTKKCDPLHRYIEKLWLEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PAH8</accession>
    <name>A0AAN6PAH8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_38775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854466">
        <property type="protein sequence ID" value="KAK4034786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PAH8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4034786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="440" mass="48031" checksum="93880B8D600F6CA4" modified="2024-10-02" version="1">MTWTLSGHARRRRCRPGPGSRCAVRDGEDPRESKPPNLGGYLIQPEFKIRGKSHTAPSMSGAPPKSEPPLKSEEQPKSEAGCDSDPQPTLLGRLDRAFSSAAQSIHAHVQNIEVDAAKSGLPPTHLVRRAAERIEAQVDRLFDVYIAIGREVDGMASELDRFAAREDGLRRDLDECKTANFKLNCAKKDLGDQVELRRLKREAEDREAEHARLEGSLCELQEERRKTAAEKLWLEQTARKNEADVEKATAETRRLQSLAHERDAEVEGLKSNNLGLQSLVQQRQAEVEVARADNVRLQSLIRDKEAQISSLSALPITPLSPMGPPGPFSLPAAPLIQASQQAQTLTSRPSSPLPYIKQEPSGITPPAAVLLQQPAPVGQPQDPAQQLYQLGAGAADVLGKLFNIDRRIPHYNVLASFLTNLGAAPEASSIAVTPATVTSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PAR1</accession>
    <name>A0AAN6PAR1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_19671</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854534">
        <property type="protein sequence ID" value="KAK4033368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PAR1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF2">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4033368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="111" mass="12068" checksum="5FBEB3E7D5426A5A" modified="2024-10-02" version="1">MSDPAAETASGLVATPAAVLTETPPNTPNHFPFMRLPPELRLMVYRYLLKTDAMIQLASARPLPCHHIGLSTAVLRLNRQISSEALSVLYGENKFSFFKFILTAGGPSPDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PB04</accession>
    <name>A0AAN6PB04_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">C8A01DRAFT_18199</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family. Isoflavone reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854455">
        <property type="protein sequence ID" value="KAK4035094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PB04"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF4">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="5">
        <location>
            <begin position="52"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="470"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="473"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAK4035094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="768" mass="85280" checksum="EB3B63AF782B86FB" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PBB9</accession>
    <name>A0AAN6PBB9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl hydrolase family 71-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_48583</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854452">
        <property type="protein sequence ID" value="KAK4035200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PBB9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051118">
        <property type="term" value="F:glucan endo-1,3-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11577">
        <property type="entry name" value="GH71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005197">
        <property type="entry name" value="Glyco_hydro_71"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03659">
        <property type="entry name" value="Glyco_hydro_71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="935"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="942"/>
            <end position="964"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4035200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1008" mass="105618" checksum="10C247FD8FF57499" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PBJ9</accession>
    <name>A0AAN6PBJ9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Phosphoacetylglucosamine mutase</fullName>
            <shortName evidence="14">PAGM</shortName>
            <ecNumber evidence="4 14">5.4.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 14">Acetylglucosamine phosphomutase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11 14">N-acetylglucosamine-phosphate mutase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">C8A01DRAFT_18201</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 14">Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, which is a biosynthetic precursor of chitin and also supplies the amino sugars for N-linked oligosaccharides of glycoproteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>N-acetyl-alpha-D-glucosamine 1-phosphate = N-acetyl-D-glucosamine 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23804"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="EC" id="5.4.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14 17">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="14 17">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.3" evidence="4 14"/>
    <dbReference type="EMBL" id="MU854456">
        <property type="protein sequence ID" value="KAK4035059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PBJ9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004610">
        <property type="term" value="F:phosphoacetylglucosamine mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03086">
        <property type="entry name" value="PGM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.50:FF:000003">
        <property type="entry name" value="Phosphoacetylglucosamine mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000013">
        <property type="entry name" value="Phosphoacetylglucosamine mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000023">
        <property type="entry name" value="Phosphoacetylglucosamine mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.120.10">
        <property type="entry name" value="Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049023">
        <property type="entry name" value="AMG1_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049022">
        <property type="entry name" value="AMG1_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016657">
        <property type="entry name" value="PAGM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45955">
        <property type="entry name" value="PHOSPHOACETYLGLUCOSAMINE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45955:SF1">
        <property type="entry name" value="PHOSPHOACETYLGLUCOSAMINE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21405">
        <property type="entry name" value="AMG1_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21404">
        <property type="entry name" value="AMG1_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016408">
        <property type="entry name" value="PAGM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="Phosphoglucomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="Phosphoglucomutase, first 3 domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8 14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7 14 17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 14 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="19">
        <location>
            <begin position="57"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="19">
        <location>
            <begin position="128"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoacetylglucosamine mutase AMG1" evidence="21">
        <location>
            <begin position="211"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoacetylglucosamine mutase AMG1" evidence="20">
        <location>
            <begin position="308"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase C-terminal" evidence="18">
        <location>
            <begin position="463"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="15">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <feature type="binding site" description="via phosphate group" evidence="17">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="383"/>
            <end position="385"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="508"/>
            <end position="512"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="517"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR016408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR016408-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR016408-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR016408-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF21404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF21405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAK4035059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="545" mass="59879" checksum="9EB5805C4B47F00D" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PC09</accession>
    <name>A0AAN6PC09_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Malic acid transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_37958</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854439">
        <property type="protein sequence ID" value="KAK4038118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PC09"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015140">
        <property type="term" value="F:malate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09317">
        <property type="entry name" value="TDT_Mae1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.150">
        <property type="entry name" value="Voltage-dependent anion channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030185">
        <property type="entry name" value="Mae1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004695">
        <property type="entry name" value="SLAC1/Mae1/Ssu1/TehA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038665">
        <property type="entry name" value="Voltage-dep_anion_channel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31162">
        <property type="entry name" value="MALIC ACID TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31162:SF3">
        <property type="entry name" value="TRANSPORTER_MALIC ACID TRANSPORT PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03595">
        <property type="entry name" value="SLAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="243"/>
        </location>
    </feature>
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        <location>
            <begin position="255"/>
            <end position="273"/>
        </location>
    </feature>
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            <end position="320"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="354"/>
        </location>
    </feature>
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            <begin position="374"/>
            <end position="402"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="414"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="442"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="23"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4038118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="480" mass="52040" checksum="14EDF6567A83EF49" modified="2024-10-02" version="1">MARPNPTRRLTSGSGVSFALVGGSGYETPMDDSTGLPWPGTPLSAPPAAPAQTKSPFFGGNMTAGGGLRRARTDLLLPGEPLSVADRLLLQQGGLGGAGVVQGGRLRGVRSPAESLNGVVMRARRGATGGIANVLHSIPYESQWLTGIGLAFFFLNLCLFVMNCVLISLRFYWRPGSLVDSFNDQYESLFISAIIVSIATILITITQYGVPYAGPWLLSVLEALFWIYIGVSTLVSASLYLTLWSTQVFPIHTMTPVWVFPAYPLLLTAPFGGNLVAAASNAGQLGGINTVPVTLAAVTVQGTGFLISFMVCAAFLYRLMTQKLPRDHQRPGVFISIGPSGFTCAGLVQLGTLTPSIFPPDFMGTQHAVHILRLLAYMMGLWLWGLSIWFFLVSVGSLWKYLRPESKGKLRFQMTWFSFVFPNTALVTATEALGGAFESPGLQIFGCVLAACLVLVWILVFTKMLRCLWRRELLWPKEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PC30</accession>
    <name>A0AAN6PC30_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_19446</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854518">
        <property type="protein sequence ID" value="KAK4033636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PC30"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="120"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="314"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="348"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="382"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4033636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="427" mass="46599" checksum="AE5B3B0E09C1AEB3" modified="2024-10-02" version="1">MTGHDHPSSEAIHSSGPLAFLHPTARYHPLTATGQDQPQPPNGSFTINTPAKPTATEDGSRENQQIYHVWRSRDNRKGRHRALVTGQGAKGRDEGRKSRLVKKTGYGLTRLVTRFPVWDISYLVAVAFVLGSVIWCINGCFVWLPLVAPASEFPGETDEGAGILAFLGATVFEIGSVLMVVEAVNAERSDCFGWALEESLEDHGLRLRPRHEGCHHPHRGRHALLKDSAVAAMAATAVDSVAEPGGLEERKGDDGNVRQWWPAWHELSTHYIKEIGFLASFVQLLGASIFWISGFTALPPIYNALSAPVMDGVYWVPQVVGGTGFIVSGLMFMVEVQDKWYKPAPKTLGWHVGFWNLIGGIGFTLCPAVGFGSQSSFALEYASGLSTFVGSWAFLIGSVAQWYESLDKYPVSVEEAPTWLPSGEKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PC45</accession>
    <name>A0AAN6PC45_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable glucan endo-1,3-beta-glucosidase eglC</fullName>
            <ecNumber evidence="5">3.2.1.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Endo-1,3-beta-glucanase eglC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Laminarinase eglC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">C8A01DRAFT_37821</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Glucanases play a role in cell expansion during growth, in cell-cell fusion during mating, and in spore release during sporulation. This enzyme may be involved in beta-glucan degradation and also function biosynthetically as a transglycosylase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;3)-beta-D-glucosidic linkages in (1-&gt;3)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.39"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 22">Belongs to the glycosyl hydrolase 17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.39" evidence="5"/>
    <dbReference type="EMBL" id="MU854435">
        <property type="protein sequence ID" value="KAK4038237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PC45"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050732">
        <property type="entry name" value="Beta-glucan_modifiers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000490">
        <property type="entry name" value="Glyco_hydro_17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631:SF13">
        <property type="entry name" value="GLUCAN ENDO-1,3-BETA-GLUCOSIDASE EGLC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00332">
        <property type="entry name" value="Glyco_hydro_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0134">Cell wall</keyword>
    <keyword evidence="17" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0964">Secreted</keyword>
    <keyword evidence="11 23" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="23">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042854892" description="Probable glucan endo-1,3-beta-glucosidase eglC" evidence="23">
        <location>
            <begin position="20"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00025152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00032134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00032906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KAK4038237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="344" mass="36656" checksum="E2C358683D161FB6" modified="2024-10-02" version="1">MRGTHCLAALAAAFSSATAQYQGFNYGAFFTDNSPKMQSDFEAKFKTAQNLEGAPGKGFTSARLYTTLQWGTASDIISAIPAAIPAAITTNTTLLLGIWCSAGHAIVSHELTALRSAITTYGSNFTDLVGGISVGSEDLYRSSPTGIANHENTGANTTALVTYIARARDAVKDTALSQVPIGHVDTWSEWADPKNRALVDAVDFVGMDAYSYWQSMVPNGVDRSKALFDDALNRTRMAVGGKGDRGRGNKPVWVTETGFPVSGKTSNEAVPGVEGARRFWREVGCGLFGGEVNVWWYTLRDAGKRTPEPSFGIVGEELGTRPLFDISCPGVGGDEEDGEGCDPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2025-10-08" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PCU8</accession>
    <name>A0AAN6PCU8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_37779</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854434">
        <property type="protein sequence ID" value="KAK4038262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14210">
        <property type="entry name" value="PKc_DYRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000112">
        <property type="entry name" value="Putative dual specificity tyrosine-phosphorylation-regulated kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF22">
        <property type="entry name" value="DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION-REGULATED KINASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="947"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="86"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="305"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="453"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="531"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="651"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1252"/>
            <end position="1333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="86"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="317"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="346"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="453"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="473"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="531"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="564"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="601"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="611"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="675"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="690"/>
            <end position="709"/>
        </location>
    </feature>
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        <location>
            <begin position="718"/>
            <end position="729"/>
        </location>
    </feature>
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        <location>
            <begin position="785"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1317"/>
            <end position="1329"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="976"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4038262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1403" mass="151713" checksum="E5ACE53A26E12ECF" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PCY1</accession>
    <name>A0AAN6PCY1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_48067</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854433">
        <property type="protein sequence ID" value="KAK4038307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PCY1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="81"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="101"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4038307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="321" mass="34906" checksum="A53DB479D3E54600" modified="2024-10-02" version="1">MWPTTANSKISQNVGPSSPPETPRTASPVFGRKSSPRPGERPPQIPLRPMAPPLSTSRAAVNGLDFSPSSAIRPEQLSPRSTSSSSASASESGDSEDSEGSEGSTNAAGPSPSAAAERRPAPTPPASQARIGRIVTQTEFIVEELSDFVGDSDEERPGVVRPCAIEYAESDGSRSASRTRPEVDQKMVFNLGNLNCSDDSDETDLDEHEYQEFLIKRRAARRHKRMTSGSIGKRTISESIGSDTDREDLRSLLGAEEAGSSARRLRRRVGDRRSLQFQDPPPPRIDELDEPDSSEDDIFVGESLARELPYYEYVSMEVDSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PD04</accession>
    <name>A0AAN6PD04_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TRIP4/RQT4 C2HC5-type zinc finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_18705</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854477">
        <property type="protein sequence ID" value="KAK4034508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PD04"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180022">
        <property type="term" value="C:RQC-trigger complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039128">
        <property type="entry name" value="TRIP4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009349">
        <property type="entry name" value="TRIP4/RQT4_C2HC5_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12963:SF4">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12963">
        <property type="entry name" value="THYROID RECEPTOR INTERACTING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06221">
        <property type="entry name" value="zf-C2HC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRIP4/RQT4 C2HC5-type zinc finger" evidence="2">
        <location>
            <begin position="238"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="477"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="171"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="477"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4034508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="531" mass="56939" checksum="CC18B1F52A2A3CBF" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PD83</accession>
    <name>A0AAN6PD83_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Actin-related protein 2/3 complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_37316</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
            <location evidence="7">Cytoskeleton</location>
            <location evidence="7">Actin patch</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the WD repeat ARPC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854420">
        <property type="protein sequence ID" value="KAK4038748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PD83"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000220">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017383">
        <property type="entry name" value="ARPC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10709">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10709:SF2">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038093">
        <property type="entry name" value="ARP2/3_su1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="50"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR038093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4038748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="363" mass="39834" checksum="CCFB0DA95C71D61C" modified="2024-10-02" version="1">MAAPEVHHLFHNPIADHSFSADHKTLAIARDTAVELYSKAGNAYKLQDELKGHDKTVTSLDIAPNSGRIVSCSQDRNALVWEPTPQGYKPTLVLLRINRAATFVRWSPSETKFAVGSGDRLIAVCYFEQENDWWVSKHLKKPIRSTVTTLAWHPNSVLLAAGSTDAHARVFSSFIKGVDARPEPTAWGERLPFNTVCGEYMNNSAGWIHSVAFSPSGDALAYAAHDSSITVVYPSAPEQPPKAVISINTQLLPFMSLIWNGEAEIIAAGHDCEAFRFQGGIGGWQLSGAVEAKGRPGMGDQREESALNMFRQMDLKGKVKDDTQLKTTHQNTITMIRPYEASGDSVRKFSSSGVDGRIVIWTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PDF6</accession>
    <name>A0AAN6PDF6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_18865</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854485">
        <property type="protein sequence ID" value="KAK4034311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PDF6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="603"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="641"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4034311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="717" mass="80459" checksum="298CD62983649865" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PE51</accession>
    <name>A0AAN6PE51_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">3CxxC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_37067</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854414">
        <property type="protein sequence ID" value="KAK4038952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PE51"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027377">
        <property type="entry name" value="ZAR1/RTP1-5-like_Znf-3CxxC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13695">
        <property type="entry name" value="Zn_ribbon_3CxxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01328">
        <property type="entry name" value="zf-3CxxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="3CxxC-type" evidence="4">
        <location>
            <begin position="60"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4038952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="166" mass="18987" checksum="BA7B09FD47980D71" modified="2024-10-02" version="1">MPFTKKPYKPKGELSRNTTAMFPSLHEDVADALSDAFISPEPWFNPTGGDDDAITVYDTHIMGRFDCRNPACAKQGWGSKKISILIRQYPDNGYNAVVFKQRCKACERVGALRLDENSYVERVTYRLKKWAGIRMETPEYNGNHRGPPHEYDLCEGCKRGYCQRVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PE91</accession>
    <name>A0AAN6PE91_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_18489</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854466">
        <property type="protein sequence ID" value="KAK4034761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PE91"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051604">
        <property type="entry name" value="Ergot_Alk_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43162">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43162:SF1">
        <property type="entry name" value="PRESTALK A DIFFERENTIATION PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="1">
        <location>
            <begin position="9"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4034761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="297" mass="32214" checksum="A6867E1D427EE295" modified="2024-10-02" version="1">MQITVVPASPKTGQAAIRVLLADASNPTVKGYYRNLAKVPAEFKSNPRFEAVQGDVEDAATLDFSGSDAVFNITPPLYEEKDIIAHARLVSENVKAAVKKADSVKRLVLLSSGGAQYDHGTGEIMTNHEAEVILKDAAPEVVLVRASYFMENWAMSLETLPAGFFFTTLTPLDQPLPMIAVQDIGATCAAELLATGTALPSNPLIFELHGPREYTSLDVQKAFEEVSGKTLEMRPVEKAGLDDFYAAVFPPTVAAQFAEMNRSFLEGGILHEDPQPTGERKYGRTELVEVVRQMLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PF24</accession>
    <name>A0AAN6PF24_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_17164</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="2"/>
    <dbReference type="EMBL" id="MU854419">
        <property type="protein sequence ID" value="KAK4038790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PF24"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46077">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TOPORS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46077:SF1">
        <property type="entry name" value="TOP1 BINDING ARGININE_SERINE RICH PROTEIN, E3 UBIQUITIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="25"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="89"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="92"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4038790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="299" mass="34464" checksum="8E422DF1668408EA" modified="2024-10-02" version="1">MDREPSPKEAAFSVQPPLDHTTKHCVICLDSVAEPCEAQPCRHGHFDYLCLVTWLQQRATCPICNSTVGQVRYELSEDGKEGKLYEVPANESGTQGQQGSSSSSGNHAGRLTRTRPYEDEAVRRRRLVYRHRLFSLRVGSNRRQPAASRYRKLTPQLFKTNPELLSRARMWLRRELRVFRFLHPDSDANAPLDVAADSAGQCRPTKAEFLEEYVLAILRTLDTQGSTGQAEEMIQEFLGRDHTRLFLHELRTWLRSPYQTLREWDRVVQYARRADASWIAPQTPEDHDAPVHLRSRLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PF72</accession>
    <name>A0AAN6PF72_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7896 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_18002</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854448">
        <property type="protein sequence ID" value="KAK4035301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PF72"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057218">
        <property type="entry name" value="DUF7896"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42031">
        <property type="entry name" value="KEY LIME PATHOGENICITY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42031:SF1">
        <property type="entry name" value="KEY LIME PATHOGENICITY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25438">
        <property type="entry name" value="DUF7896"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7896" evidence="3">
        <location>
            <begin position="420"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="35"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="168"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="267"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="472"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="7"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="169"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="268"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="285"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="488"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4035301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="698" mass="74973" checksum="240FA45DDACA6F93" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PFP6</accession>
    <name>A0AAN6PFP6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA-directed RNA polymerase II subunit RPB3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_16842</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854409">
        <property type="protein sequence ID" value="KAK4039135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PFP6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07031">
        <property type="entry name" value="RNAP_II_RPB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.120.12:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.12">
        <property type="entry name" value="DNA-directed RNA polymerase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00320">
        <property type="entry name" value="RNApol_arch_Rpo3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001514">
        <property type="entry name" value="DNA-dir_RNA_pol_30-40kDasu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011262">
        <property type="entry name" value="DNA-dir_RNA_pol_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011263">
        <property type="entry name" value="DNA-dir_RNA_pol_RpoA/D/Rpb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022842">
        <property type="entry name" value="RNAP_Rpo3/Rpb3/RPAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036643">
        <property type="entry name" value="RNApol_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050518">
        <property type="entry name" value="Rpo3/RPB3_RNA_Pol_subunit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001988">
        <property type="entry name" value="PRK00783.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800:SF2">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01000">
        <property type="entry name" value="RNA_pol_A_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01193">
        <property type="entry name" value="RNA_pol_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00662">
        <property type="entry name" value="RPOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56553">
        <property type="entry name" value="Insert subdomain of RNA polymerase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00446">
        <property type="entry name" value="RNA_POL_D_30KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RpoA/D/Rpb3-type" evidence="9">
        <location>
            <begin position="27"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="307"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="307"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="326"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00072506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4039135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="340" mass="36678" checksum="76FE805530C4AB8D" modified="2024-10-02" version="1">MDYDPMVMDDAEAMGPVVKISQADSVRVKYELSNADIAFANSLRRVMLGEIPTIAIDLVEIEENSSVLADEFIAHRLGLIPLNADGVESLLYARDCDCDGCCEHCSVRLTLHAKCTGDENMHVFARDLVPTGDRVNQVVGTPVLSDAEGLGPLILKLRPGQEIKLECIAKKGIAKEHAKWAPSAAIGFEYDPHNKLRHIDYWYETDAKAEWPPSEYASWEEPPQEGEPFDYDAVPNRFYFNVESAGNLPPDTIVSEGIKVIQQKLAGLIHELADEGGDGMNGDYNGPRSPEYGTGADGFGGYTTPFGNGGGNQSSWGGAGAGGTTPYGTTPYGAGQSSWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PFP7</accession>
    <name>A0AAN6PFP7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_15991</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854384">
        <property type="protein sequence ID" value="KAK4040083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PFP7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042968320" evidence="1">
        <location>
            <begin position="21"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4040083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="398" mass="44030" checksum="8DE7A651FB670C02" modified="2024-10-02" version="1">MLSFTTAALSLLLAVTGVDAGNRAWEPPIHYAKAAIAARDLSGVNNIYFNGTNVSSDHHAHQKRFFGINTPANSQSYPRLWPNGNIDACFEQVDHQHDGQMKSTRAILYDGLIAARELWRQEGLDDNKGFRFNILPDNDAGCQRNLRSTHLLIIYAGQGSTKMATTVGIDQPQAAPESNAPDSMLGPTITLSDSLEVGMENVVANFAHELGHAWGLHHEHQNPKWWHETLSGVDRGDNWFFSEENFHCENLKGFDELMAAYNGQPDYISRPFRNKICRNRGQAGAQQFAGGFNYIPITDEPNTIDDGRNEPDWDSIMLYPSHAGGKIVAGVKQVVLTKRNGDLIQPVFKPSKRDVAGLKKMYGVKSSFLGKILGDTGNSLKNKFDSIRKKDKDSGCSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PGF2</accession>
    <name>A0AAN6PGF2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_16400</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854395">
        <property type="protein sequence ID" value="KAK4039643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PGF2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF11">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="378"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="403"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="440"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="479"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="51"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="510"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="510"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4039643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="532" mass="57670" checksum="D5496F876E8E3521" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PGY1</accession>
    <name>A0AAN6PGY1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nad dependent epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_16954</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854413">
        <property type="protein sequence ID" value="KAK4039016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PGY1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05227">
        <property type="entry name" value="AR_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000191">
        <property type="entry name" value="Methylglyoxal reductase (NADPH-dependent)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="5"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4039016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="355" mass="38043" checksum="6F32A50652EA2204" modified="2024-10-02" version="1">MARRVLLTGANGFIGQHILAFFLDAGHSVRSVVRSQAKADQLAKTFSEFASSSQLDFSIVPDMTSPGAFDQALESEPPFEWVVHTASPFNYSKVTSNHDFLDPAVKGTTEILQAIKRNAPSVKRLVLTSSMAAVIDFAAPKSTHPAKVYTEADWNPTSWETALVTENKNLAYQASKKYAEKAAWDFVAANPDGFDLAVINPPMVFGPLYDAAQFSSPAELNQSTSNIYNALLNPALSADSPMPPTGLHLYVDVRDVARAHLLAAATPAAGGKRFIACGGQLSFQRIANLLRASLPALSGRIPRGTPEEATMPEGSFEASSELARTVLGLDFRSAEDTIGDLATQLVDIESRGALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PHE3</accession>
    <name>A0AAN6PHE3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bystin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_16926</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bystin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854412">
        <property type="protein sequence ID" value="KAK4039029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PHE3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007955">
        <property type="entry name" value="Bystin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12821">
        <property type="entry name" value="BYSTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12821:SF0">
        <property type="entry name" value="BYSTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05291">
        <property type="entry name" value="Bystin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="69"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="462"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="29"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="474"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4039029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="483" mass="54020" checksum="91708D2568739E97" modified="2024-10-02" version="1">MPKAATASLSSKRRHNPLEDDLVATGVLKNREGRPSKRADRKQAEEQAYVDAKASRKILAMSRDLIDEEELRSGANDQHVSAPSAFDFDPSRLEGGSDQEEEEFANEEAWGDEEDIVEEIEVDADDLETFNRFITPTMNDDPLLTHGWDRKPGDGAEEQGAGTNLADLILAKIAEKEAMQGGRQQQDYNPIEEDYEMPPKVVEVFTKIGLILARYKSGPLPKPFKILPQIPHWEDILQITRPDLWTPNACYAATRIFVSAKPLVVQRFMEMVVLERVREDIYENKKLNVHLFNCLKRGLYKPAGFFKGFLFPLAASGTCTLREAQIISAVLARVSIPVLHSAAAIKTLCDIAAEQASQQSESVSATNFMLKVLLEKKYALPWQCVDSLVFHFLRYAAAASPGDAPPRSLPVIFHQCMLVFAQRYRNDITEDQREALLDLLLNHGHDKIAPEIRRELLAGRGRGVPVEQPGPAFDGDDTMLVDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PHT6</accession>
    <name>A0AAN6PHT6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_35677</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854379">
        <property type="protein sequence ID" value="KAK4040348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PHT6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4040348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="213" mass="22814" checksum="D043A2001D1A284B" modified="2024-10-02" version="1">MAESKTTTVPNGDSPQSTTLRHLLTLPAVQDGVRAFNANPLGKMSVQLTNSAYQMVGAPVLSLFNKPLAYVTPYAQRVDELGVQTLSRVEERYPIVKKPSPELLQGAREAAYAPVRHVTDVYRGAYQKEATGYHTLASGRAAAKTVAVVSVEGAIFALREALKLGESFQITESIKAAVDQLEEALKQRQNGNAAGDAETANPGRDESLKASST</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PIC8</accession>
    <name>A0AAN6PIC8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_35301</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854372">
        <property type="protein sequence ID" value="KAK4040648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PIC8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4040648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="195" mass="22561" checksum="96C9D9ED54E63D55" modified="2024-10-02" version="1">MIPVESPPFLPLILTCKRLYFEGVCEFFETVTPVFTTSLDAHRFFLERPHPLLHCLLHLELNLTHSRDHPYLPGVEHPQPLLPGVPRTPRYECGLSLCRRDLYGAENWDRLIRGIRRAAPHLQQLDVNVRSEAELETILDPFGAVDDERARGYGDVDEHDLWEVPGRLVVQFSVAGERTAYEQRGRRMVRLELPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PIJ9</accession>
    <name>A0AAN6PIJ9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_34625</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854359">
        <property type="protein sequence ID" value="KAK4041322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
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        <location>
            <begin position="17"/>
            <end position="41"/>
        </location>
    </feature>
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            <begin position="374"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4041322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="405" mass="43833" checksum="A433FEA28BE0850B" modified="2024-10-02" version="1">MFTARFPARAGARTLLRSSRTQRRFQSSQAGPSSSQSSHLASGVAGGIAGAGLLYGIYLMTPTGKMTRKINTAAREADKKYQQAAATIKDKTPSTDEAVDKLKQFCYSYVAWVPGGRQYVDTAFGDLGAIRESHGEEVDKIVSETYREFQDIARTGLSLESASKANEALANLAKKIASLSGSAADQLLERHPQLNDKVGGPIRQLKEMGAQYGPEAQKLVDETWSQVRDVMASGFSAESADKVRKIVEERTQQMRKMGDDLWDKGVEQAQPYLDKSPRLKELVTSNRDLLKEGNVAGLLKQIKSLGEGGDAAKVEDYVRQAVDKAKAKGSQAGGGAFAALSQFLGSDDAGKLQDKMGVLSEVVSKHSSEGAALLEETRKDVRKLLAEKAQKAQKIVDSAKEKKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PIV7</accession>
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        <submittedName>
            <fullName evidence="5">UreD urease accessory protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_45136</name>
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        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">CBS 284.82</strain>
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    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="project" value="UniProtKB-ARBA"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <feature type="domain" description="SCD" evidence="4">
        <location>
            <begin position="677"/>
            <end position="760"/>
        </location>
    </feature>
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    </feature>
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        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
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    <sequence length="1546" mass="170193" checksum="B67549AEF363355C" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PIX6</accession>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
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                <person name="Brannstrom I.O."/>
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                <person name="Cros-Aarteil S."/>
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                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
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                <person name="Yan M."/>
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                <person name="Ng V."/>
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                <person name="Ament-Velasquez S.L."/>
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                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <feature type="transmembrane region" description="Helical" evidence="2">
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    <feature type="transmembrane region" description="Helical" evidence="2">
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    <feature type="transmembrane region" description="Helical" evidence="2">
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    <feature type="transmembrane region" description="Helical" evidence="2">
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    <feature type="transmembrane region" description="Helical" evidence="2">
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    <feature type="transmembrane region" description="Helical" evidence="2">
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        </location>
    </feature>
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        <location>
            <begin position="1"/>
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        </location>
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        <location>
            <begin position="10"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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        <location>
            <begin position="610"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAK4041838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="661" mass="73271" checksum="73B23AF9CDFED703" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PIY9</accession>
    <name>A0AAN6PIY9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WD-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_36625</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854401">
        <property type="protein sequence ID" value="KAK4039415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PIY9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046925">
        <property type="entry name" value="WD-like_fungi"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20493">
        <property type="entry name" value="WD-like_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042828385" description="WD-like domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="WD-like" evidence="2">
        <location>
            <begin position="70"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4039415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="179" mass="18774" checksum="D24CC46336C41FEB" modified="2024-10-02" version="1">MQLKTLTLAALLAAVQVSALPSPITNAPNTAEHGLIILSTTFHDDGGVETVYGADPAFTNTTASPSSPLTRRCGSNTIHCSGSNVPALNTCQDLVARIRTSSNVLNSSPRSICLSRSGRSCCISWATDIGAVHESDLWSAAKKTMDQCVPEGNSGRATDVLINGRCLDQCLSDRATHCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PIZ2</accession>
    <name>A0AAN6PIZ2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Kinase domain-protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_35105</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854368">
        <property type="protein sequence ID" value="KAK4040830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PIZ2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043484">
        <property type="term" value="P:regulation of RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051175">
        <property type="entry name" value="CLK_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE DOA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646:SF11">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE DOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="41"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4040830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="432" mass="48035" checksum="E934B113A67E5949" modified="2024-10-02" version="1">MVKHIKSTRSLPAGRGRGEARVLPARGDHPILIGDRLHERYRIAHKLGHDIFSTLWLARDEQLSRYVAVKVGTADSADSSHREVDILSQLSNSNARDGTGKGFFPAVLDSFNLESPNGTHPCFVTAPARYSLADTKQASSGLFQLDVARSLAAQLTLAVVHIHEQGFVHGDLHLGNTLLHLPSPLDALPETNLYTKYRAPEPEPILRLDGAPLTQGVPLPRDPPPNIWLGDESETIPLRNTNLLLTDFGTAFRLSTESRFASYTPLEIRPPEARFAPATPLSFASDIWSLGCTVWALLAHRSLFDALWLASEDNVAAQWVDVVGVGCLPAEWWGVWEAWPKYFTEVGPGRQPVGGRRAWSLGRRYEEWVVEPRRERGLATMGDGEREAFLGMVRGMLAFQPRDRLSAKEVLEMEWMREWAMPEYVKGLSLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PJA1</accession>
    <name>A0AAN6PJA1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_46537</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854385">
        <property type="protein sequence ID" value="KAK4040049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PJA1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4040049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="93" mass="10558" checksum="C3163748F617DD3A" modified="2024-10-02" version="1">MNSDDLMSDPAHPMHHPSDSKGASWNTQKFRDEYELYKNRLQDQRFSVAAYPDPLSPRPPHPKQYPKGTSPELERQLQELIARVKAGRDGGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PJM1</accession>
    <name>A0AAN6PJM1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ubiquitin-like modifier HUB1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_46332</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854379">
        <property type="protein sequence ID" value="KAK4040351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PJM1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039732">
        <property type="entry name" value="Hub1/Ubl5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13042">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="4">
        <location>
            <begin position="159"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="25"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="140"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00014108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4040351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="234" mass="27333" checksum="826853022BED104A" modified="2024-10-02" version="1">MPDSPRRRSRSRSPPRRPKAGGGFKWKDKRSTDADDRRDDRGLQRGYRDRSPRRDRERDRDYGRDRDRERDGNRDRSPRRNRSRERDRDREREREGDRDRDRPRRSDNNRDRSPRRDRDRDAQPNPKPTPRKEPPATTNKPPPRPPPPQTGAAAGEEMIIVTVNDRLGTKAQIPAFPSDTVGQFKIMVAMKVGREPHEILLKRQGERPFKDMITLGDYGVSNGVQLDLEVDTGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PK39</accession>
    <name>A0AAN6PK39_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ATP-dependent 6-phosphofructokinase</fullName>
            <shortName evidence="14">ATP-PFK</shortName>
            <shortName evidence="14">Phosphofructokinase</shortName>
            <ecNumber evidence="14">2.7.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Phosphohexokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">C8A01DRAFT_44489</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14 15">
            <text>beta-D-fructose 6-phosphate + ATP = beta-D-fructose 1,6-bisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="14">Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 14 15">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.11" evidence="14"/>
    <dbReference type="EMBL" id="MU854340">
        <property type="protein sequence ID" value="KAK4042474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PK39"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005945">
        <property type="term" value="C:6-phosphofructokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070095">
        <property type="term" value="F:fructose-6-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048029">
        <property type="term" value="F:monosaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061621">
        <property type="term" value="P:canonical glycolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030388">
        <property type="term" value="P:fructose 1,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.460:FF:000007">
        <property type="entry name" value="ATP-dependent 6-phosphofructokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.460:FF:000008">
        <property type="entry name" value="ATP-dependent 6-phosphofructokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.450">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.460">
        <property type="entry name" value="Phosphofructokinase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03184">
        <property type="entry name" value="Phosphofructokinase_I_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009161">
        <property type="entry name" value="6-Pfructokinase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015912">
        <property type="entry name" value="Phosphofructokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02478">
        <property type="entry name" value="6PF1K_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13697:SF4">
        <property type="entry name" value="ATP-DEPENDENT 6-PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13697">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000533">
        <property type="entry name" value="ATP_PFK_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="Phosphofructokinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00433">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 14" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="10 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12 14 15" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="9 14 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphofructokinase" evidence="17">
        <location>
            <begin position="66"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphofructokinase" evidence="17">
        <location>
            <begin position="457"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal catalytic PFK domain 1" evidence="14">
        <location>
            <begin position="1"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal regulatory PFK domain 2" evidence="14">
        <location>
            <begin position="457"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="215"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="137"/>
            <end position="138"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="167"/>
            <end position="170"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <begin position="213"/>
            <end position="215"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <begin position="257"/>
            <end position="259"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <begin position="349"/>
            <end position="352"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <position position="533"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <begin position="591"/>
            <end position="595"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="629"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <begin position="636"/>
            <end position="638"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <position position="696"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="722"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <begin position="728"/>
            <end position="731"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <position position="800"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR000533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAK4042474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="845" mass="92246" checksum="FA9D2F94994E57C6" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PK91</accession>
    <name>A0AAN6PK91_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_35438</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854374">
        <property type="protein sequence ID" value="KAK4040574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PK91"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF120">
        <property type="entry name" value="KRUPPEL-LIKE FACTOR 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="256"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="288"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="319"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="112"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="395"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="177"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="204"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="399"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4040574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="416" mass="46252" checksum="477C235F7B4B4A3A" modified="2024-10-02" version="1">MEHTPPPALTRSPSSPANTYCPSERSSLDYPSPGLVEQQYKISSLYGDQSCVTPPMDPELSLPPLDSMGHADWNSTTVIHPISSASSMPSILSADYDTFGSYPYNHDVYHAHPTSHASTPPPTGSAPRSPAAPLRTPYTPATSVPAPMTPRVKMEGTSDYSQSTDGSHYPSPRSIHTSYPSDSGPYTSSTSTGYLSDSGSTAWHKPEYQPVEPEHYYPGPPPPPPSAFMHDARRQYRVARPKRAPRRLTTKEEANFQCEVKGCGKLFSRSYNFKAHMETHDEKREYPFPCLVPDCSKKFVRKTDLQRHHQSVHLRERTHKCDYCSRMFARKDTLRRHMEDGCSKRFDIGTMDIRAEAGYDNMHPSARSMAPMGHMGLPPIGIPPLCGSSMLGSMPPSMRPREPLVGGDHHSHTWGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PKA1</accession>
    <name>A0AAN6PKA1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Calpain catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_45365</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854356">
        <property type="protein sequence ID" value="KAK4041520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PKA1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calpain catalytic" evidence="3">
        <location>
            <begin position="168"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="322"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4041520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="491" mass="53802" checksum="3C8F87BF1EEE5189" modified="2024-10-02" version="1">MTGSKPEQPDSPPKHLHIGAINPFALVEAILGRKVDWNEAATARVLSSILQTDYEELFDMRFKSILYAGTRLNDRGDQAELIPAKDMHTLTERDLVTPDFSKVEKLGDLGHMGLKDLDNMRVKHALMSNGNLRLTLEQRTVGKTLCSSEMTRTLRELCTPFRLNEKEEWTPPNGSWADIGGCYHQDPATFSNPVQGAASNSWLVAALMSVAWSDPSVIKHCTRRHSSSSSCGHEDSSHKTRDCSLSVKLHSKGGDNDASTTTVTVNCELPTNNSSSLLMYCRPSSMSSMAPTHMIRTWGGDLWPALYEKAFAAWLTGSHSSSAASTATAPGGGTSRSSEHPDLTQTAHGDPIKAMAQLTDKNPQYFFTSARRGADLLGLVRTHCVNQSTVFPTVAWTKPSDEKFRGCTLVGNMAYSVLGWAAPQERKQYIVLRHPWGVTEPEGMTSYPGVVARVDAKFWPPVQLVDEQGAGVFAIETGYFKEYFAGMGVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PKD1</accession>
    <name>A0AAN6PKD1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_34301</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854353">
        <property type="protein sequence ID" value="KAK4041698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PKD1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046670">
        <property type="entry name" value="DUF6540"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20174">
        <property type="entry name" value="DUF6540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4041698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="169" mass="18253" checksum="C02E459A81FBF6BE" modified="2024-10-02" version="1">MPLRGEIIAPSVSLDARSVQGTYHWGLIIMDSAEKGSFHHATNPSGGWKYEKRNASPAQSITLITVVRVSGLNGSVQAATDVIQSVPADGSPSQRTGEAFRCLSWLKDAIVALDAAGIIQLPMDIDTLIRVAKHYAEENRTDAELGHGAYVEKNPDPNKGDSYTMYLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PKJ6</accession>
    <name>A0AAN6PKJ6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP synthase subunit d, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Alpha-NAC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Nascent polypeptide-associated complex subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">C8A01DRAFT_44496</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ATPase d subunit family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the NAC-alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854340">
        <property type="protein sequence ID" value="KAK4042482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PKJ6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005854">
        <property type="term" value="C:nascent polypeptide-associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22054">
        <property type="entry name" value="NAC_NACA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14358">
        <property type="entry name" value="UBA_NAC_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.30:FF:000002">
        <property type="entry name" value="Nascent polypeptide-associated complex (NAC), alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.30">
        <property type="entry name" value="Nascent polypeptide-associated complex domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008689">
        <property type="entry name" value="ATP_synth_F0_dsu_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036228">
        <property type="entry name" value="ATP_synth_F0_dsu_sf_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016641">
        <property type="entry name" value="EGD2/NACA0like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038187">
        <property type="entry name" value="NAC_A/B_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002715">
        <property type="entry name" value="Nas_poly-pep-assoc_cplx_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21713">
        <property type="entry name" value="NASCENT POLYPEPTIDE ASSOCIATED COMPLEX ALPHA SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05873">
        <property type="entry name" value="Mt_ATP-synt_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01849">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01407">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161065">
        <property type="entry name" value="ATP synthase D chain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51151">
        <property type="entry name" value="NAC_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="9" id="KW-0138">CF(0)</keyword>
    <keyword evidence="18" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NAC-A/B" evidence="20">
        <location>
            <begin position="49"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="120"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="287"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="20"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="127"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="144"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00014437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00021688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00030300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAK4042482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="360" mass="40057" checksum="B23958B00C3CE633" modified="2024-10-02" version="1">MADPRIEELPDEETKKPTVEELDDSSSDESDAEAGDASLPAGSTSVIHSRNEKKARKAIEKLHLTRVPGITRVTLRRPKNILFVINNPEVYKSPNSNTYIVFGEAKIEDLNASAQAAAAQQLANQTAEHDHAGHAHDHKHEAAKEEEEEDDGEEVDAEGIEDKDIELVMTQANVSRKKAIKALKENDNDIRSAALKVDWAKITTSLGLRGQTVAGLQAFKKRNDDVRRKVQLLAEQPTTVDFAQYRAVLKNQAIVDEIEKRFNAFQPATYDVARQLKAIEAFEVEAVKNAEATKEKVDLELKDLDKTLRNIEEARPFEDLTVDEVAAAEPSIDEKTSKLVSKGRWAVPGYKERFGDLSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PKL0</accession>
    <name>A0AAN6PKL0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glutamate--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Glutamyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">C8A01DRAFT_15315</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Glu) + L-glutamate + ATP = L-glutamyl-tRNA(Glu) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.17" evidence="3"/>
    <dbReference type="EMBL" id="MU854368">
        <property type="protein sequence ID" value="KAK4040831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PKL0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017102">
        <property type="term" value="C:methionyl glutamyl tRNA synthetase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004818">
        <property type="term" value="F:glutamate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1160.10:FF:000001">
        <property type="entry name" value="Glutamine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.800.10:FF:000001">
        <property type="entry name" value="Glutamine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000037">
        <property type="entry name" value="Glutamine--tRNA ligase cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.240.10:FF:000004">
        <property type="entry name" value="Glutamyl-tRNA synthetase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1160.10">
        <property type="entry name" value="Glutamyl-trna Synthetase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glutamyl-tRNA Synthetase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal Protein L25, Chain P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02076">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050132">
        <property type="entry name" value="Gln/Glu-tRNA_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004526">
        <property type="entry name" value="Glu-tRNA-synth_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
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        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_codon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020061">
        <property type="entry name" value="Glu_tRNA_lig_a-bdl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_bL25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_bL25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049437">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00463">
        <property type="entry name" value="gltX_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097:SF5">
        <property type="entry name" value="GLUTAMATE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097">
        <property type="entry name" value="GLUTAMINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03950">
        <property type="entry name" value="tRNA-synt_1c_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20974">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="Ribosomal protein L25-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13 17" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9 13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic" evidence="14">
        <location>
            <begin position="121"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding" evidence="15">
        <location>
            <begin position="429"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA synthetases class I (E and Q) anti-codon binding" evidence="16">
        <location>
            <begin position="533"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF03950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF20974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAK4040831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="638" mass="72600" checksum="40977D4176A4DCD6" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PKM3</accession>
    <name>A0AAN6PKM3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_45868</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854368">
        <property type="protein sequence ID" value="KAK4040846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PKM3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="487"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="530"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="302"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="495"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="539"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="551"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="561"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="586"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4040846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="615" mass="68545" checksum="9D15201CA94FDA0B" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PKX0</accession>
    <name>A0AAN6PKX0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_35005</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854366">
        <property type="protein sequence ID" value="KAK4040949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PKX0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4040949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="292" mass="32116" checksum="BADECFE69A5316EA" modified="2024-10-02" version="1">MAPAPGLDSEQYEIRQLQPGDTDAASAILSVATAFDSPFFELMVQYQAIPKPARVYALFDTHVPVVSRHIESGLSYGVFNKHYISPRGHANPSSVLWACPDTRDEAPTKIKLLSQIDSPLVSVALSNDATDPQYFDGAGNWIPPAIRELCELKAMLRQLDTAPPKLWQPTERGQMLLREGTFTRSDYAGRGLAKALSYWLMDEMARQGYRTIEVDTYHPAVTKIWQNPPAPFAASVGCELLPGWSDTIAGKVLMGDNVLVDRLCVECKRIYVSLVPDAGEAGLEALVMEGFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PL83</accession>
    <name>A0AAN6PL83_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mitochondrial F1-F0 ATP synthase subunit F of fungi-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_15533</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854373">
        <property type="protein sequence ID" value="KAK4040585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PL83"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019727">
        <property type="entry name" value="ATP_synth_F0_fsu_mt_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28161">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT F, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28161:SF1">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT F, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10791">
        <property type="entry name" value="F1F0-ATPsyn_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4040585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="101" mass="11229" checksum="7046620FDA177A67" modified="2024-10-02" version="1">MSFVTRRALSTLIPPKVASPKAIGAAPDAVRMQRVVNFYEKLPRGAAPEVKPTGILGRYQAKHFGKNPSAKPIIHAIVFLVAIGYAQNYYFHLRHHKNNAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PLI1</accession>
    <name>A0AAN6PLI1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA 3'-terminal phosphate cyclase/enolpyruvate transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_33882</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNA 3'-terminal cyclase family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854346">
        <property type="protein sequence ID" value="KAK4042118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PLI1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000479">
        <property type="term" value="P:endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.20:FF:000004">
        <property type="entry name" value="18S rRNA biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.20">
        <property type="entry name" value="RNA 3'-terminal phosphate cyclase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.20">
        <property type="entry name" value="RNA 3'-terminal phosphate cyclase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013791">
        <property type="entry name" value="RNA3'-term_phos_cycl_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023797">
        <property type="entry name" value="RNA3'_phos_cyclase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037136">
        <property type="entry name" value="RNA3'_phos_cyclase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000228">
        <property type="entry name" value="RNA3'_term_phos_cyc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016443">
        <property type="entry name" value="RNA3'_term_phos_cyc_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036553">
        <property type="entry name" value="RPTC_insert"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03400">
        <property type="entry name" value="18S_RNA_Rcl1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096">
        <property type="entry name" value="RNA 3' TERMINAL PHOSPHATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096:SF1">
        <property type="entry name" value="RNA 3'-TERMINAL PHOSPHATE CYCLASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01137">
        <property type="entry name" value="RTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05189">
        <property type="entry name" value="RTC_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="EPT/RTPC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNA 3'-terminal phosphate cyclase" evidence="5">
        <location>
            <begin position="10"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="RNA 3'-terminal phosphate cyclase insert" evidence="6">
        <location>
            <begin position="211"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4042118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="407" mass="42341" checksum="9B7D8F79C36C0F10" modified="2024-10-02" version="1">MSGSKPEFLRFTGHRAFTQRLVLSTLTGRPIHISKIRSASPTNPGLAPHEVSFLRLLEAVTNGSVIDVSYSGTTITYQPGLITGTTPGAGSSLASDAIEHVLPANCARAVTYFLLPLALLAPFSKAHMNVRFSGPGVITSATAATGDLSIDTFRTALLPLYGQFGIPPARIELRVLSRSCPGPGGRGGGGVVELRFASQVRLPKTLHLNRRPGRIRRIRGVAYCTGVSASHNSRMITAARGVLNQLVSDVHVAAQYDPAPLVAEKGGAGKKKIGIGFGLSLVAESSADGVFYAADEVAPPQGGVVPEDIGTRCAYQLLEVIAQGGCVTGAAAPTVLTLMAMGAEDVGRLRLGRDVMAREEIIGLARDLKQFGASSWGIRDAGDDDGAGDLIISVKGTGVGNVGRKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PLP6</accession>
    <name>A0AAN6PLP6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Guanine nucleotide-binding protein subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">C8A01DRAFT_43879</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">G proteins are composed of 3 units, alpha, beta and gamma.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G protein gamma family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854330">
        <property type="protein sequence ID" value="KAK4043241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PLP6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031681">
        <property type="term" value="F:G-protein beta-subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.260.10:FF:000003">
        <property type="entry name" value="G-protein complex gamma subunit Ste18/GpgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.260.10">
        <property type="entry name" value="Transducin (heterotrimeric G protein), gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015898">
        <property type="entry name" value="G-protein_gamma-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036284">
        <property type="entry name" value="GGL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041848">
        <property type="entry name" value="Ste18_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28189">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28189:SF1">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00631">
        <property type="entry name" value="G-gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01224">
        <property type="entry name" value="G_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00224">
        <property type="entry name" value="GGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48670">
        <property type="entry name" value="Transducin (heterotrimeric G protein), gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="7" id="KW-0564">Palmitate</keyword>
    <keyword evidence="10" id="KW-0636">Prenylation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="G protein gamma" evidence="13">
        <location>
            <begin position="110"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="G protein gamma" evidence="12">
        <location>
            <begin position="114"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="25"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="81"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK4043241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="180" mass="19983" checksum="8DB81F03F529A3A2" modified="2024-10-02" version="1">MAEQHDYHESTDPWSRFSAADSHTGESSGASRLQQQPTDPSRWASEEGTSPRAPPPPSNPEDTPATRVPNRDFPSRPSPAVTISSSRMPQYTSRDVGDPSQIKKNKQSMADLKLRRLTELNSRLREDLERERIPVSQASKSIIAYCNSTRDYMVPNVWGPVPKGDDPYAPQQSGGCCIVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PLV3</accession>
    <name>A0AAN6PLV3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_32693</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854330">
        <property type="protein sequence ID" value="KAK4043202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PLV3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050869">
        <property type="entry name" value="H3K4_H4K5_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197:SF273">
        <property type="entry name" value="MYND-TYPE ZINC FINGER PROTEIN SAMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SET" evidence="4">
        <location>
            <begin position="233"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4043202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="570" mass="63917" checksum="A62119021EE4B87F" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PMS8</accession>
    <name>A0AAN6PMS8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase</fullName>
            <ecNumber evidence="4">4.1.3.44</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">tRNA wybutosine-synthesizing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">C8A01DRAFT_34205</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:36347"/>
            <dbReference type="Rhea" id="RHEA-COMP:10164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10165"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64315"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="EC" id="4.1.3.44"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">tRNA modification; wybutosine-tRNA(Phe) biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TYW1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.44" evidence="4"/>
    <dbReference type="EMBL" id="MU854352">
        <property type="protein sequence ID" value="KAK4041716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PMS8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102521">
        <property type="term" value="F:tRNA-4-demethylwyosine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031591">
        <property type="term" value="P:wybutosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000196">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013917">
        <property type="entry name" value="tRNA_wybutosine-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034556">
        <property type="entry name" value="tRNA_wybutosine-synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13930">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE-DEPENDENT TRNA 4-DEMETHYLWYOSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13930:SF0">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE-DEPENDENT TRNA 4-DEMETHYLWYOSINE SYNTHASE TYW1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08608">
        <property type="entry name" value="Wyosine_form"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00284">
        <property type="entry name" value="tRNA_wybutosine-synthesizing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01071">
        <property type="entry name" value="tRNA_wybutosine-synthesizing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="12" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="17">
        <location>
            <begin position="131"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="18">
        <location>
            <begin position="455"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="67"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="311"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="750"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="326"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="774"/>
            <end position="790"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00071388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00077859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAK4041716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="790" mass="88523" checksum="BCE2DB5BB4E92B74" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PNB5</accession>
    <name>A0AAN6PNB5_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_34360</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854354">
        <property type="protein sequence ID" value="KAK4041635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PNB5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050562">
        <property type="entry name" value="FAD_mOase_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47356:SF2">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47356">
        <property type="entry name" value="FAD-DEPENDENT MONOOXYGENASE ASQG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="6"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4041635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="444" mass="48796" checksum="1EBFCD058F017789" modified="2024-10-02" version="1">MASNFKVIIVGGGPVGLTAAHALHQAGIDFVVLERRETLFNDEGASLVVSPPTLRLMHQLGLLSSVRSIGADIQRVKSFDLAGHRFAHHLGIFDAMKKNHGAAPMAFHRAELVEAFHHGLPADAKAKVLTGKKIVDMASDDAGVRVTCADGTAYSGSLILGADGVHSQTRRFMRRLALAADPTADWEPEEPFPAEYRCMWCSFPRPGEAGLGTDTQHKDRSTMYLSGKDRAWIFLYEKLPEKTAQRARYTGKDIEEYAAKFADFPIDDKLYVRDVFDKSTAGMANLEEGVAKHWSWGRMVLVGDACHKVTPNAGRGYNNGAQDVVALANRLQGALRSSADGTLDNATLAGLFDDYQRTRTEAMQSDASISAHVTRLHAWSNTLYYIFARHIAPWGFVQRYIQNQLSAPQIAKSLILDYVPAEEPLKGSVPWEHPMPSVPLSNKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PP15</accession>
    <name>A0AAN6PP15_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_42961</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854320">
        <property type="protein sequence ID" value="KAK4044292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PP15"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000111">
        <property type="term" value="C:nucleotide-excision repair factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071942">
        <property type="term" value="C:XPC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.20.110">
        <property type="entry name" value="Rad4, beta-hairpin domain BHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2460">
        <property type="entry name" value="Rad4, beta-hairpin domain BHD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.260.10">
        <property type="entry name" value="Transglutaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018327">
        <property type="entry name" value="BHD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004583">
        <property type="entry name" value="DNA_repair_Rad4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018325">
        <property type="entry name" value="Rad4/PNGase_transGLS-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018326">
        <property type="entry name" value="Rad4_beta-hairpin_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018328">
        <property type="entry name" value="Rad4_beta-hairpin_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042488">
        <property type="entry name" value="Rad4_BHD3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036985">
        <property type="entry name" value="Transglutaminase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12135:SF0">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-C CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12135">
        <property type="entry name" value="DNA REPAIR PROTEIN XP-C / RAD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10403">
        <property type="entry name" value="BHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10404">
        <property type="entry name" value="BHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10405">
        <property type="entry name" value="BHD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03835">
        <property type="entry name" value="Rad4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01030">
        <property type="entry name" value="BHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01032">
        <property type="entry name" value="BHD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="7">
        <location>
            <begin position="972"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="407"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="499"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="615"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="667"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="857"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="51"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="72"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="408"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="673"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="687"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="865"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="875"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="913"/>
            <end position="924"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4044292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1136" mass="124990" checksum="8D3D1ED5BE790ED4" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PP48</accession>
    <name>A0AAN6PP48_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_12211</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854319">
        <property type="protein sequence ID" value="KAK4044387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PP48"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14097:SF9">
        <property type="entry name" value="EPIMERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G07320)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14097">
        <property type="entry name" value="OXIDOREDUCTASE HTATIP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4044387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="224" mass="24244" checksum="0AFB4C661EB0A8B6" modified="2024-10-02" version="1">MKVIVTGCNGLVGSALVRQCIASDKISHVFALTRKPLDEAVAKSPKATVILHDDFSTLPPALLHQLAGAEGCLWAIGGRATQFPDVETYRKVQVDYTVAAAKAFRETLAPQLPEGAQFRFVFCSGKFAEWDQAKPLHFMADTRRVKGQVEQGLCEVADADAAKRFVVYCARPSGILPADAGFAARAAGKLYSAIDVDHLAKALVRILLEGHKERIIENDTLLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PPI0</accession>
    <name>A0AAN6PPI0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">rRNA 2'-O-methyltransferase fibrillarin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Histone-glutamine methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">C8A01DRAFT_31031</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-glutaminyl-[histone H2A] + S-adenosyl-L-methionine = N(5)-methyl-L-glutaminyl-[histone H2A] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50904"/>
            <dbReference type="Rhea" id="RHEA-COMP:12837"/>
            <dbReference type="Rhea" id="RHEA-COMP:12839"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61891"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. Fibrillarin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854316">
        <property type="protein sequence ID" value="KAK4044844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PPI0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990259">
        <property type="term" value="F:histone H2AQ104 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008649">
        <property type="term" value="F:rRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000494">
        <property type="term" value="P:box C/D sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000452">
        <property type="term" value="P:snoRNA guided rRNA 2'-O-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000056">
        <property type="entry name" value="Fibrillarin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000001">
        <property type="entry name" value="Fibrillarin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00351">
        <property type="entry name" value="RNA_methyltransf_FlpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000692">
        <property type="entry name" value="Fibrillarin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020813">
        <property type="entry name" value="Fibrillarin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003276">
        <property type="entry name" value="PRK04266.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10335:SF17">
        <property type="entry name" value="FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10335">
        <property type="entry name" value="RRNA 2-O-METHYLTRANSFERASE FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01269">
        <property type="entry name" value="Fibrillarin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006540">
        <property type="entry name" value="Nop17p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00052">
        <property type="entry name" value="FIBRILLARIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01206">
        <property type="entry name" value="Fibrillarin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00566">
        <property type="entry name" value="FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="26"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK4044844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="323" mass="33592" checksum="2452EB34FF005811" modified="2024-10-02" version="1">MGFERGGRGGGRGGGGFRGGGDRGGRGGARGGGRGGAGFGGRGGGRGGGPGGRGGRGGPRGGARGGRGGGPGGAKGGKKVIVEPHRHKGVFVARGGKEDLLATTNLVPGESVYGEKRISVENAAKGEDAATTKTEYRIWNPFRSKLAAGILGGLETIYMKPGSKVLYLGAASGTSVSHVADIVGPTGAVYAVEFSHRSGRDLINMATRRTNVIPIVEDARKPMAYRMLLPMVDVVFADVAQPDQARIVGINARLFLKQGGGLLISIKASCIDSTAPPEQVFASEVQKLREDKFFPKEQLTLEPYERDHAMVSCVYLQKEFEAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PPN6</accession>
    <name>A0AAN6PPN6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">CASC3/Barentsz eIF4AIII binding-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">C8A01DRAFT_33203</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CASC3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854337">
        <property type="protein sequence ID" value="KAK4042676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PPN6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035145">
        <property type="term" value="C:exon-exon junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018545">
        <property type="entry name" value="Btz_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09405">
        <property type="entry name" value="Btz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01044">
        <property type="entry name" value="Btz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="11" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="10" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Btz" evidence="14">
        <location>
            <begin position="139"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="143"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="630"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="56"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="144"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="160"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="630"/>
            <end position="662"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK4042676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="733" mass="80064" checksum="BA23FA76F31725BB" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PQM9</accession>
    <name>A0AAN6PQM9_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">C8A01DRAFT_32676</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="MU854330">
        <property type="protein sequence ID" value="KAK4043186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PQM9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045719">
        <property type="term" value="P:negative regulation of glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14004">
        <property type="entry name" value="STKc_PASK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000320">
        <property type="entry name" value="Serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000314">
        <property type="entry name" value="Serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057213">
        <property type="entry name" value="DUF7891"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF51">
        <property type="entry name" value="PAS DOMAIN-CONTAINING SERINE_THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25421">
        <property type="entry name" value="DUF7891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="937"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="256"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="496"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="791"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="847"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="904"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="284"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="301"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="315"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="499"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="525"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="803"/>
            <end position="812"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK4043186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1198" mass="131000" checksum="D69FE77D95EACA96" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PSJ3</accession>
    <name>A0AAN6PSJ3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferric-chelate reductase (NADPH)</fullName>
            <ecNumber evidence="3">1.16.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">C8A01DRAFT_32115</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2 a Fe(II)-siderophore + NADP(+) + H(+) = 2 a Fe(III)-siderophore + NADPH</text>
            <dbReference type="Rhea" id="RHEA:28795"/>
            <dbReference type="Rhea" id="RHEA-COMP:11342"/>
            <dbReference type="Rhea" id="RHEA-COMP:11344"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.16.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.16.1.9" evidence="3"/>
    <dbReference type="EMBL" id="MU854324">
        <property type="protein sequence ID" value="KAK4043795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PSJ3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052851">
        <property type="term" value="F:ferric-chelate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000067">
        <property type="entry name" value="WGS project CABT00000000 data, contig 2.6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF23">
        <property type="entry name" value="FERRIC-CHELATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="219"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="294"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="493"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="15">
        <location>
            <begin position="377"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="637"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="761"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="649"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="669"/>
            <end position="683"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAK4043795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="913" mass="102458" checksum="26187F1166031FAB" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PTX6</accession>
    <name>A0AAN6PTX6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Sacsin/Nov domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_11884</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854316">
        <property type="protein sequence ID" value="KAK4044806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022155">
        <property type="entry name" value="DUF3684"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058210">
        <property type="entry name" value="SACS/Nov_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF047352">
        <property type="entry name" value="P_loop_sacsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47839">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G04830)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47839:SF1">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G04830)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12449">
        <property type="entry name" value="DUF3684"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25794">
        <property type="entry name" value="SACS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sacsin/Nov" evidence="2">
        <location>
            <begin position="26"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1430"/>
            <end position="1545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1753"/>
            <end position="1776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1513"/>
            <end position="1526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4044806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1776" mass="195195" checksum="B22DD091270EAC7D" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SK05</accession>
    <name>A0AAN6SK05_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_42321</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU855004">
        <property type="protein sequence ID" value="KAK4031196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SK05"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47178:SF5">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47178">
        <property type="entry name" value="MONOOXYGENASE, FAD-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="8"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4031196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="398" mass="42655" checksum="16C299492E978763" modified="2024-10-02" version="1">MSSPTPKPVLIAGAGIASLLLAQSLRLAGIPFLIFERDTSFDFRAQGYRLRLSAEGLDAIESVLDADTWQRFWDACGKTGGTSVFTAYNAVTGEDTTEKSAVPQRGLALASRDGKVVGIARGDMRRIFAQGCEEQIQWRKDVTGYELTDDGVRAVFADGTKSVEGSLLVGGEGIRSQVAKQLSGGRIKVYDTGARGIHGQAPTTAFKDLGEGVFVIRDDTRPEGAFSVITNVRAGDMDNPSINFGWTMAGQPGVIRAPNDDYTIVGTQAAALAKSLTANWHPRFQPLFDHMNEEEAAFWKITCSSPSGVPEWPNQPRVTVLGDAAHAMTPAAGIGANTAVRDSALLGRLLREAGGFAPGVTEAYEREMRAYASEAVDISYTAATKQWSMKIDENTPTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SL38</accession>
    <name>A0AAN6SL38_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Isoflavone reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_21472</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family. Isoflavone reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854898">
        <property type="protein sequence ID" value="KAK4031287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SL38"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF4">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="4">
        <location>
            <begin position="8"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4031287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="320" mass="35208" checksum="9ED8680E74231763" modified="2024-10-02" version="1">MAIIAVAGGTGNVGRAIIGAILATGKHEVKILSRKPNPELEVEIGAPIVPVDYSDVDAVVKVLEDNNIHTVVSGLAMHSADGKPPLEIELIRAADRSKATKRFISSAWGVPVTDEHIGTVPSVIHKINAQQELQKTTNLEYTVFHTGSFMDYWGIPAVKTFLDRMPLVFWLDMANNAAALPGSGNTPAIFTHTTDVARFVAASLDLPSWEPETFVFGDRATWNEILHWAEEVKGTKFNVAYDSREKLERGEVTELPGQVPLYPFFPKPAQQAMGAGFGRWFEDGVFDMKPANGARFLNDTFPDIEPLTIKELLEKAWKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SL66</accession>
    <name>A0AAN6SL66_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_42341</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ISY1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU855042">
        <property type="protein sequence ID" value="KAK4031170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SL66"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000350">
        <property type="term" value="P:generation of catalytic spliceosome for second transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.660">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029012">
        <property type="entry name" value="Helix_hairpin_bin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009360">
        <property type="entry name" value="Isy1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037200">
        <property type="entry name" value="Isy1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06246">
        <property type="entry name" value="Isy1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140102">
        <property type="entry name" value="ISY1 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4031170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="68" mass="7933" checksum="08C9B344E597E604" modified="2024-10-02" version="1" fragment="single">MPCWEASAQVLKEISRKVSRIQDPALSDYQIRDVRLGCRISGWHTVSTRASPEPLGSYRRHRWSTQYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SLF8</accession>
    <name>A0AAN6SLF8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Tyrosinase copper-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_41874</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854729">
        <property type="protein sequence ID" value="KAK4031678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SLF8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF116">
        <property type="entry name" value="TYROSINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00497">
        <property type="entry name" value="TYROSINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042878526" description="Tyrosinase copper-binding domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="3">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="4">
        <location>
            <begin position="319"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4031678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="398" mass="42829" checksum="001FFDB3EF45A01A" modified="2024-10-02" version="1">MRLTVLSSVVLIGAAFAQSAPDPTADALAQFQDLTAEAQAAQDDLLSSTATTSSKRANTCTKDKLLVRKPWGSLSNLERKAYTDAVLCFQKLPAKTPTGLVPGVRSRYDDFLATHINQTLNIHYTGTFLAWHRWFTWTYEQALRNECGYTGAQPYWNWALYAKDPASSPIFDGSDYSMSGNGEYIAGKGPITLLLGDYAPVVLPPGTGGGCVTTGPFKNYTINLGPVSMPLNNGSVIGGGPGTGLAYNPRCMKRDISAAINTAFANATSVVKLLTRNTIADFQLVMQGVPGSGNIGVHGGGHYTIGGDPAGDVFSSPGDPAFYLHHGMIDLTWWVWQMLDFTHRRNQISGTQTFLNQPPSPDVTLDDTIDLSYAGGGPITMRELMSVNDGPFCYTYSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SM17</accession>
    <name>A0AAN6SM17_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_50885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854626">
        <property type="protein sequence ID" value="KAK4032292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SM17"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006886">
        <property type="entry name" value="RNA_pol_III_Rpc5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12069:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12069">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES III 80 KDA POLYPEPTIDE RNA POLYMERASE III SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04801">
        <property type="entry name" value="RPC5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="209"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="296"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="374"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4032292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="414" mass="43576" checksum="2174CC611675A250" modified="2024-10-02" version="1">MASTQPSREAPTTSSDDDDPVVANYSVFIKPTLPEHRNLVVLQYVNKTAQDPAQIRVPRIAELRMKPSTGMYEVDVPIDTAEAYDRNKGVAWGSALQKSMEAKKGGSLGLAGGFNMVATSTTARGRRGGGGGGAGASTDDEPPLNWAEAARQDKVLRTQTFGGGRSAEEESTRHMIENLHLTPVSSVVHLRPVPHHLDAATEQERLTRGGSAATANSGGAPEKPGAGATAGRAIHMTIKSAMDADGGVATETMADRLRNVQTETWQRMEWVHDEAEMAWEAYNECLLLRSSGAANNHNNSNAAQEEGGGGEGGEGENKAKGKGKEKEIEAAGDESGAADLVDKVSRLRTDWGEQELLQAGKEAVVKTEERPAEGQKQAGRAGRGAAAASAAAGATGTRKSTRRGATRGNAMEID</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SMI0</accession>
    <name>A0AAN6SMI0_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="8">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_19900</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the tannase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="8"/>
    <dbReference type="EMBL" id="MU854551">
        <property type="protein sequence ID" value="KAK4033104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SMI0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030600">
        <property type="term" value="F:feruloyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011118">
        <property type="entry name" value="Tannase/feruloyl_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938:SF13">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07519">
        <property type="entry name" value="Tannase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4033104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="522" mass="55765" checksum="C31CFD7B47701E10" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SMK3</accession>
    <name>A0AAN6SMK3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Isopropanol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_50452</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854570">
        <property type="protein sequence ID" value="KAK4032847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SMK3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05188">
        <property type="entry name" value="MDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051397">
        <property type="entry name" value="Zn-ADH-like_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43677:SF4">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43677">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="2">
        <location>
            <begin position="31"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="1">
        <location>
            <begin position="189"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4032847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="372" mass="39773" checksum="CF2C76BD754B81BD" modified="2024-10-02" version="1">MATDTYQAAVLTELGAPLQLETRTIPQPAQGSAVVKVLAAPVLPYMKQVLDGTRGYPLTLPIVPSSSCIARVHAVAGDAVRLRPGQLVLCDLTIRARDQPATTILQGLNAFSAPALMAQWADGSFAEYAVFPLENVFALDEDRLLRRLGYSVEDLCLISACNVAFGGLAALDVKPGEKVVVCPATGRFGGAAVATALAMGARVWAAGRNAETLRALALPYADTGRIETVVLGGDLEQDKKTLLETAGGEGFDCYVDFSPPQAADSNHIQACLGSLRPFGRAVLNGGSLGAVSIPYLELMLKSLRIYGRFMYEREHTVRLIQMVEAGLLPLGDRINSKTVGRFKLDQIYEAMELASKESGWGKQVVLLPQGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SN18</accession>
    <name>A0AAN6SN18_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_19678</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854535">
        <property type="protein sequence ID" value="KAK4033357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SN18"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF42">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="44"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4033357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="347" mass="38558" checksum="BDE21681DF338BC9" modified="2024-10-02" version="1">MTSDSGPAKRELTLPSDSGDASIFGQTSVAVWVLTAASGAFLFVRLWCRHRFSKLWWDDVVLTVSWAVLLVAAALLARTITSGYTTDDEQRRFFLFQNTATSMTTLATAWTKVAFAITLSRIVRNRGLLYFLWFVIVTANLILIPGMLSIWIPACTDPRAIFRPQHATCFDLPILQYLGGATIVYGGVIDVLLALFPWFIIRKLLLETREKLGLTLAMSLGALTGTIVIFRAFYQLREMDNDYHFMVFMSIFNFLEPGVTIIAQAIPMFRVLVVKVKNGSSAVRISSPTGLAESGSAPRRTWNSKASHGRYADEELLHVRVGPGGRIVRISGPEGSDDDLKVYDGRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SN46</accession>
    <name>A0AAN6SN46_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_19321</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854510">
        <property type="protein sequence ID" value="KAK4033779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SN46"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4033779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="124" mass="13473" checksum="F772EE2EB4F680FE" modified="2024-10-02" version="1">MPLASTLPTGSKPALPATTTNITRVILSNGYRAYHPKTETDKPAKPKKTVRFVKGHTTIPDPVALSEAGSDSEIGDDFDFLHDFSLEEAEGWVPVMVAEEDEGDDWMSLTGSWIRLGDVGDAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SNB3</accession>
    <name>A0AAN6SNB3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_19158</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854501">
        <property type="protein sequence ID" value="KAK4033959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SNB3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4033959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="89" mass="9128" checksum="68CB48BA25F301F2" modified="2024-10-02" version="1">MPESKADKIDRVKADLPLPEQPPAASDMKSANMKTTSSTGVSAGDVSTGAGVTSGLREPATKASGDVDMSGIGRQGKEGLEQTPKDARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SNP7</accession>
    <name>A0AAN6SNP7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_49626</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854506">
        <property type="protein sequence ID" value="KAK4033855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SNP7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02603">
        <property type="entry name" value="HAD_sEH-N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052898">
        <property type="entry name" value="ACAD10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47829:SF1">
        <property type="entry name" value="HAD FAMILY PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47829">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4033855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="291" mass="32024" checksum="7FD03330D6A0C7F6" modified="2024-10-02" version="1">MAQPPSEKRPKVILFDIGGVCVVSPFQSILDYELSLGIPPGWINYSISRTAPSGFWHRLETGSIPMDAAFFAGFNRDLHDPARWEAFYRAHQQQQAPNSSLPQQIPPVPKLDGEWLFFDMMASARAPDPWMYPALKALKASGRYIVAALSNTVIFPPEHEYSRGDFFDDPLRSLFDVFVSSAHVGLRKPDPRIYRLALERVDAFARENAGSERGQGLGWEEGVSAGEVVFLDDIGENLKAAKGAGFGTIRVPLGRAYEAVEALEGVTGLALAGDHPKIPVKPNFRGSKSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SNZ6</accession>
    <name>A0AAN6SNZ6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GPI anchored serine-threonine rich protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_38853</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854469">
        <property type="protein sequence ID" value="KAK4034694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SNZ6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042938052" description="GPI anchored serine-threonine rich protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="94"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="128"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="170"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4034694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="351" mass="34530" checksum="66329802E81E1671" modified="2024-10-02" version="1">MHKLILLGLLPAAALAGRASSPFLLRRTDSTEAQTCEELGMQDCGGCIPLDYSCCPAKLGGCAADMVCVIADDGQDGCCPDGYTCTGNGGVTSTTFAPKPTATATGNGDLPMYSEVPGPTLDPPSPTDEPTSSASTEEAPTPTPPQDAAQPSTTGPASSSETASEKPTVSTTLSESASDSTSATASSATTSSTGSLPPFPANSTTTPPYGTGTGSVIVVTETIAVSTTICPPVVESPPLPTPTTTIIDINPQGAATTTVVAPVIKPGVVCPGHGEACHPVIVDDGDTGSAIPIPSHTTGVYHQIGSTGTGGVTRPSKTGQAVVTAGASSKMVGGVRAAVVVGVAGVVAGYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SPE6</accession>
    <name>A0AAN6SPE6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_38908</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854471">
        <property type="protein sequence ID" value="KAK4034650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SPE6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.20.10">
        <property type="entry name" value="Crystallins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042913209" evidence="1">
        <location>
            <begin position="22"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4034650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="123" mass="13757" checksum="59C235D4C2E2CE1C" modified="2024-10-02" version="1">MHPNFLNIAMLSWLSVMTANALPTEEAPVKRASPGLYLCENARFQGYCYHYTTPWGVCTTITDHFPSGDRGVSAAGADWGNWCTLYSQENCRGEELQVYYPGYENLANTGWNDKARSYNCAAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SPH2</accession>
    <name>A0AAN6SPH2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_38628</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854461">
        <property type="protein sequence ID" value="KAK4034932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SPH2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000034">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000068">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF46">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="328"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="378"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="413"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="444"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="58"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4034932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="501" mass="56358" checksum="4A6029CE7E5E4DDD" modified="2024-10-02" version="1">MSELKHPSDEEDVKRHAAANGASHDVPPPYDAASTSGEVVCPPHTTERKITTRIDMYIIPFVSILYLMAFLDRVNIGNARAFGLEDELGLGGVEYNTALTIFFVPYIICEIPSNILMKHFSPRVWLSLCCIGFGAVTVFQGLVRSYGGLLTTRFFLGLFESAMFPGCFYLLSTWYRRHEAQKRFSLFFSSTSLAGAFGGLLASGIGKMDYVRDYRGWRWIFIIEGSFTVVLGVIFLFTFPSFPEQATWLRDDEREFVKARLRASQGESGAERKITLRDVRTVMSDYKIWLGAFMYFGLIVPAYSYAYFAPTIIQSYKYDAITTQLRSVPPWVVSFGFSMVVAVFSDWAKHRFLFVIGSISIAIAGFAILINVHDNLQVQYAALFLTCMGTYAAMPVIVCWFNMNLAGHHRRAIGSAWQIGFGNIGGIISTYSFVKSDGPFFTKGYAICVSFICLSIVASILYAAAITWENKKRSKQVHDLNLTESEKMDLGDMNPEFRYML</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SPH7</accession>
    <name>A0AAN6SPH7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Siderophore biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_48777</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the lysine N-acyltransferase MbtK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854460">
        <property type="protein sequence ID" value="KAK4034947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SPH7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016410">
        <property type="term" value="F:N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006769">
        <property type="entry name" value="MCU_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31438">
        <property type="entry name" value="LYSINE N-ACYLTRANSFERASE C17G9.06C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31438:SF1">
        <property type="entry name" value="LYSINE N-ACYLTRANSFERASE C17G9.06C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13523">
        <property type="entry name" value="Acetyltransf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04678">
        <property type="entry name" value="MCU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcium uniporter protein C-terminal" evidence="3">
        <location>
            <begin position="307"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="36"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="209"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="539"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="53"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="209"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4034947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1012" mass="113620" checksum="E2420CC6450D19AE" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SQE2</accession>
    <name>A0AAN6SQE2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_37811</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854435">
        <property type="protein sequence ID" value="KAK4038228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SQE2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="133"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="197"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4038228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="312" mass="35012" checksum="DB06A7876B5AD3A6" modified="2024-10-02" version="1">MPRITSNEDDYQTVIMPRARSDEDEYKPGWGTRVLQGVKVGVIVFIGLSVIPMGIMASITTMLAWVFLAVRVIYVYIETAFLTVFDYFFAGWRYPHLGTVDYRTTMYNYGQYWTAPHPHAIYRGYRYGYGSSSDGSSSDSEGSTSSPTARSFPPMRRYLSPSDKRPRRRRSTTTASAPGLHKRGDWRDEWRAPTGITATPETSSSSSSSSTTAAATPETSSSGSSSSSSSSSSSRGSSSRTPTERRRRNSAAAALTTPSNSNKKRAVTFETPSPRSSMALRERREAENRRRFEEQEREEYEKYFLRADLANW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SQF9</accession>
    <name>A0AAN6SQF9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fungal-specific transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_47996</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854431">
        <property type="protein sequence ID" value="KAK4038361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SQF9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF39">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="274"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="274"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4038361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="486" mass="53026" checksum="9CA30B8DE18AD7AD" modified="2024-10-02" version="1">MALASAEVTCKTWGTRQGPGPDLIEHRVSESQGPNLRLSWPHAGDRRRAVVGKSPLPRAASREPHAGTRIIQVSQRDMEMHYYLSHQAPKGNTPETISGPLLTPAIQAGEQDLIQYFQLAASRSLATFGRDPADLGDVVIRVALARNTASSTALFHALLALSLLHRHGDNPQAVERKIAALEALTAASGRPIDATEAMQHVATNMLLCSLEIHKVSCSSGEWTCYLRSAKDIIQAAGLDELPHDSDLVALLDWVYYHDVLARFSLRHWHRESSKLSPSSTVASSPSGVSPTTQSPRAEPSKSASPPLALIQLLSEVCDAASGHPPSMTTAEQAEHKSFLKILDWRIRSLELPAPADGDADASLVMELYRLAMLVYLSRASENLRNPSARTQQHIDKAFAMLARLGSCDRQFPVFVLGCEARSDDQRAVVLDLIARTEKGSASRSFNLVRLLLQASWAQDELGKGGMDYWDKLNCIVSCCKILPAFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SQX7</accession>
    <name>A0AAN6SQX7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_16702</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854404">
        <property type="protein sequence ID" value="KAK4039307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SQX7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="106"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4039307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="161" mass="16768" checksum="89A69CC10AAC0754" modified="2024-10-02" version="1">MSEQAAPQPIPGMENPNIHPETVNGIRAPEAHDISMTDAPAQAPPPQHLQHPPTSTTPTTAAPSPLQVPTARVPTPVPAPGQPQQQQPQQQQQPTSRAASQHPDPSTTATTTTTTSTAATAAPGFTMPSEAAPHGAPVRQYINGKITGVLLEGMKLVAREQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SR19</accession>
    <name>A0AAN6SR19_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_16178</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854389">
        <property type="protein sequence ID" value="KAK4039904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SR19"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="38"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="306"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="184"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="72"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="359"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="417"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="458"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="500"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="529"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4039904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="578" mass="62488" checksum="539E2F4C714FB17D" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SR70</accession>
    <name>A0AAN6SR70_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sterol uptake control protein 2-like protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_36779</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854405">
        <property type="protein sequence ID" value="KAK4039290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SR70"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053157">
        <property type="entry name" value="Sterol_Uptake_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784:SF5">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00755">
        <property type="entry name" value="AFLATOXINBRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="33"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="77"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4039290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="452" mass="50259" checksum="0B3615141CC91B23" modified="2024-10-02" version="1">MNGSLASPSPAATPGSLHGPVKRRRAHHKTKTGCTDCRRRRVKCDEKKPSCRACVRRRVPCNYTVEGRVVTDASLELPPTPYTAASRLSSHLPSPPQRPFTEPPLTAATPAHPQGHSAHSSTFSTEDLALHHHWTVSTSLSIAREPSCADIWQRVFPEVGFHHPFVTHAILSLAALHLAHSSSSSRRHAGEGTRESDAYVARAAEYHNAGLRGFRQSVADGIAEANSEALFVWSLLNMIYVFGMFRCQAPRNAPRAKDLVLGVEWIPMTRGIEAVLAPTHNHLRFGRMRRLVSVGNWDELEPGPPAGSSSRGGRVDACLCRARETWTDQNGGSDAAAETYDEALRILRKCRMYIEQFETMDAATLAEWGYNRAWAGPLMFVHFVPHAYFTLLHQRQPPALVLFAYFGALLHGVDDFWYMEGLGKEIVEVVGDLLGSYWRPWISWPLEFVGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SR81</accession>
    <name>A0AAN6SR81_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_35880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854384">
        <property type="protein sequence ID" value="KAK4040099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SR81"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4040099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="229" mass="25587" checksum="F34306901C04A0A5" modified="2024-10-02" version="1">MASYHRVLRVHGRSVQQKSIECDYDIHPWDILINGERWAGKVRLVGFVDSFFLICYSGQSRFEHGIVVYKDDDVIRSTLQRADVDPAAIGLSVVNKSKVEAEGSTEPPKYFQFESEKGGLDYRITSLGHPIGLKTEYPKSSLGKYEIKLQKGRDRVMKKRIKRGVRQHDLFDQMHDAVRLGIITHAELLGVIIGKTYGGSVLEDVTAKYFDGIAGSGGSKNLSLSGERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SRF3</accession>
    <name>A0AAN6SRF3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_36196</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNR ribonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854391">
        <property type="protein sequence ID" value="KAK4039817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.690:FF:000001">
        <property type="entry name" value="Cell wall biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.700:FF:000002">
        <property type="entry name" value="Cell wall biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000100">
        <property type="entry name" value="Cell wall biogenesis protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041505">
        <property type="entry name" value="Dis3_CSD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041093">
        <property type="entry name" value="Dis3l2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050180">
        <property type="entry name" value="RNR_Ribonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355:SF9">
        <property type="entry name" value="DIS3-LIKE EXONUCLEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17877">
        <property type="entry name" value="Dis3l2_C_term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17849">
        <property type="entry name" value="OB_Dis3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNB" evidence="4">
        <location>
            <begin position="741"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="102"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="386"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="493"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="599"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1186"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1265"/>
            <end position="1308"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="50"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1077"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="102"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="144"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="165"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="234"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="266"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="286"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="392"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="517"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="534"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="604"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1211"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1271"/>
            <end position="1281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4039817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1363" mass="148596" checksum="64F5F9CCB18B33B6" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SRQ6</accession>
    <name>A0AAN6SRQ6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_36462</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854397">
        <property type="protein sequence ID" value="KAK4039593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SRQ6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4039593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="75" mass="8626" checksum="40BE5DE123DA3E62" modified="2024-10-02" version="1" fragment="single">MSPHATQGTAAGGEEGRTPRHWIMGREAFEQRMPHHDGIKALWETRWKLPCSKSLYPFHDGAYEDFAPIFEELIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SRW8</accession>
    <name>A0AAN6SRW8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_35656</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854379">
        <property type="protein sequence ID" value="KAK4040327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SRW8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="321"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="370"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="416"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4040327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="617" mass="67665" checksum="F1B7A55400B74FE9" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SRZ7</accession>
    <name>A0AAN6SRZ7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_15683</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854377">
        <property type="protein sequence ID" value="KAK4040417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SRZ7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4040417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="60" mass="6991" checksum="E55C751537A28C35" modified="2024-10-02" version="1" fragment="single">ANCYISKTLNFGQRTTSLVESVNRYLKSFLVNGNSTVFVLIRQSFYIVKEMQRNIREVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SS73</accession>
    <name>A0AAN6SS73_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_35295</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854372">
        <property type="protein sequence ID" value="KAK4040642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SS73"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4040642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="351" mass="36985" checksum="8869828160A3E909" modified="2024-10-02" version="1">MTFRTGQSYPTCAGVGCGSSCKGYFCEGNPLTQNPDFLDPRNPDSVQNPIGPYYGDWDGTITRSTTAVPGPSTTSKQVPTITAVCQATTTLNDGSPLSYCDCGTGYASTLPLIPSTTAPCDYTALPRICHHGASPQQGLEYCNCDGYPHTLPTLAGEARTDAAGNVLACETSTVEAQATACAGASYTATRAPEPTATPHRRCITAHVVMGNCILNGDVVAVQAWEEGAQTCKGGKRVDFASFDTEFDIDCGGGVRVAVSGNAGKVVYHAADGWEAELAIEHGAFDTYQCGWMERANGAGYSITVALGIVGAAIKRLDDRYTKIADDKDQKIERSRIQPAAQAIEAEQKQPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SSB8</accession>
    <name>A0AAN6SSB8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_34711</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854360">
        <property type="protein sequence ID" value="KAK4041299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SSB8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4041299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="274" mass="30678" checksum="8603835569CC46A3" modified="2024-10-02" version="1">MNQFLELGLSAKQIEEINAGLDHDALNSFAWPMEWEQYQESSPVDLTFQEADLVTDMVEDSDMVEETHMTNESDDGYPEELAITPRPAEEADDDYDDAFDLSIRPEAQPDLGLVDFDHSPIVARHAVCLPNSAPGPFPEINDPIFNQLKALDAGLLVPYIGEAMNYQQALQSPVPELYNPIGSPIFGQGGTLQPFLFNGAQFSENQQLADQQLINLQPMQGFLDLLQQVQANPLSQVPFQMPPPMFIQNFFAANTINVSYDRRDQIPCQQGFIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SSX5</accession>
    <name>A0AAN6SSX5_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_34559</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854358">
        <property type="protein sequence ID" value="KAK4041362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SSX5"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15482">
        <property type="entry name" value="Sialidase_non-viral"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38792">
        <property type="entry name" value="BNR/ASP-BOX REPEAT DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_7G06430)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38792:SF3">
        <property type="entry name" value="BNR_ASP-BOX REPEAT DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_7G06430)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="Sialidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043032452" evidence="1">
        <location>
            <begin position="17"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4041362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="375" mass="41117" checksum="E4EBD18954ABC40F" modified="2024-10-02" version="1">MKWSTLVLSLLPLVAAAPKQKTPDTFSQRVIFTPPADYRDPRVLYARSAELKDGTLLATWENYSPEAPPVYFPIYRSTDGGYSWKEISRVQDTENGFGLRYQPFLYVLDKPLAGFPKDTVLLAGSSIPSDLSSTHIDLYASTNGGKNWKFVSHIAAGGEAIPNNDKTPVWEPFLMRNGNTLICYYSDQRMNETYGQKMVHQTTTDLRNWGPVVDDVTSSVYTERPGMPTVARLPNGKYIMTYEHGGSPVSSGYQFPVHFKVVSDPEKFGPATGVPLRLTDGSIPTGSPYVVWSSVGGKNGTIIASAHSSGDIYVNTGLAEPGSTWTRVATPEVGAYTRHLRVLKDQTKLLIMGGGQLPPASNNKVQLSVMDISKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6ST10</accession>
    <name>A0AAN6ST10_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_34551</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854357">
        <property type="protein sequence ID" value="KAK4041467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6ST10"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="329"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4041467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="483" mass="52763" checksum="0C564B13BB6FDF43" modified="2024-10-02" version="1">MAPRFPTAAVASREAVDGVFSGQISTLQRRQDGRNNSKNTTQIAAFVLGSLIALIIILFTARHFYQRYRRRHTYQQAGRDEDAHPNTRQINRRNQTNLEGALTDARTQPATGGNTPGTGGGGVDRNTSVRSVMTLPVYRPKPTDNELVLGREGERDGIDVVVEMRTAEEEEALRDEEMEALYQIRAARRRQIADREERQRARREARDTRDAVALRELRERTRASATRNVEEIEDLRAGHDRIRETRQRAVSSVSYADVGVARADGTRVRANSTESTERVGLLSDTASIAGESLFRRRDRSVSATLSIDTSLTAHGRPDSPGVLSTGGYSLATSAGRTTTRSRASSAATAPRMPTPSPGTTPRAGSPPEIIEPEDADLGEMGMPPPGYDEVSLDEVTPMHSRRNSDVSRPVSPYPDAPPDYPGPGPAERRNNRLSAHMEDLAAQSHTEAEGGAGAEGWGGQPRLPSLRLDQVPQIVIEPSSARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6ST47</accession>
    <name>A0AAN6ST47_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_15086</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854363">
        <property type="protein sequence ID" value="KAK4041151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6ST47"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4041151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="202" mass="22241" checksum="D16F661C0FFBBB4C" modified="2024-10-02" version="1" fragment="single">MGDPASLLAMPVEIQLAICNQLVQCDTAAQLGSNLCTLENLPVLGGLALTCRHFQQITTPFLYQRVKVSIYQQAVFFRLIERFSRFPAHAALVKELTIDSSFDNMESTLSGVQADILLQKATFLGLKLPPGGIGMPFQPESMLIDALLCQVPTIRKLVLSVPWTVAAAHVQGEHPDYDGDVRYEVPSYALRLPDSFVLPSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6ST83</accession>
    <name>A0AAN6ST83_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Probable electron transfer flavoprotein subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">C8A01DRAFT_45609</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ETF beta-subunit/FixA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854362">
        <property type="protein sequence ID" value="KAK4041168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6ST83"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009063">
        <property type="term" value="P:amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08830">
        <property type="entry name" value="ArfGap_ArfGap1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01714">
        <property type="entry name" value="ETF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000014">
        <property type="entry name" value="ADP-ribosylation factor GTPase-activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000011">
        <property type="entry name" value="Electron transfer flavoprotein subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000049">
        <property type="entry name" value="ET-Flavoprotein_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012255">
        <property type="entry name" value="ETF_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033948">
        <property type="entry name" value="ETF_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21294">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN BETA-SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21294:SF8">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01065">
        <property type="entry name" value="ETF_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="13">
        <location>
            <begin position="14"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="135"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="214"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="361"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00070315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAK4041168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="659" mass="69733" checksum="CD2F0FBE122AF4FA" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6STW3</accession>
    <name>A0AAN6STW3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Peroxin-10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">C8A01DRAFT_44546</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the pex2/pex10/pex12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="EMBL" id="MU854341">
        <property type="protein sequence ID" value="KAK4042412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6STW3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016562">
        <property type="term" value="P:protein import into peroxisome matrix, receptor recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16527">
        <property type="entry name" value="RING-HC_PEX10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000395">
        <property type="entry name" value="Putative Peroxisome biosynthesis protein (Peroxin-10)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025654">
        <property type="entry name" value="PEX2/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006845">
        <property type="entry name" value="Pex_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23350">
        <property type="entry name" value="PEROXISOME ASSEMBLY PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23350:SF0">
        <property type="entry name" value="PEROXISOME BIOGENESIS FACTOR 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04757">
        <property type="entry name" value="Pex2_Pex12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="7" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="14" id="KW-0653">Protein transport</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="12" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <keyword evidence="11 19" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="21">
        <location>
            <begin position="366"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="20">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00041230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAK4042412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="418" mass="45776" checksum="86E269F25EEA3638" modified="2024-10-02" version="1">MASQPPPSRPPPRLTSSPYPFAAAPDIIRAQQKDAYFQGVLTNQLSDLHRRLRGARSAHAWAAETRTFADALYLCLTTLLGNRTLGEEYCDLVQVEAPIPPQPSPHPIKEDDPVTPGGSGPLLPSLPLRAGYITTSILLPYLASRTLPSLRSALRKRLQSRLATLTRRDDDNKPTRRPSTELRVVRYLLAHLTPLTSGAHFHAVTLAVFYFTGAYYSLSKRIWGLRYVFTRRVEDQAGGSGMGGARAGYEVLGVLLVVQMLVRGWLHVREQLASATQVAEGGEDDEFRERIAFGPGASVEVSMDEHAFASNNELLGGGGSSSSQRSLGEIGAMAHTPVPKAGRARYDLGAGEAVMGWIKGAQQRKCTLCLEELKDPAATQCGHVFCWACIGDWVREKPECPLCRREAMVQHILPLRFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SV09</accession>
    <name>A0AAN6SV09_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Short-chain dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_32865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854332">
        <property type="protein sequence ID" value="KAK4043073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SV09"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4043073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="343" mass="37008" checksum="3CA97E35C65D5CF0" modified="2024-10-02" version="1">MFNPLAIAWHFLERQLRPLPVPDTSYAGRTVIVTGANGGLGLEAARHFARLGAARVVLACRSTERGEAAKADIEQSLTTGTTTSTPTVVEVWPLDLCSFDSVRAFCRRADAELDRLDVLLANAAMLIIDGAQMAEGYEMQVTTNVISTFLMVFMLLPLMRRTAARWNVEAAVTVVVSEAHFWTRFVQKDQPRIFECFRPGGAMQERYGTTKLLDMLMAQELAARLDAASAAGASPIVVNTANPGLCKSSLFRNLFLVGQFLLAVGTAILGRTSEQGSRALMAAVAGGRESHGKYVDSGRVDEPSAFVLSEEGKAAQKKAWGELMEILEGIEPGVTAVVTQVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SV63</accession>
    <name>A0AAN6SV63_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Peregrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">C8A01DRAFT_32728</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854330">
        <property type="protein sequence ID" value="KAK4043238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15670">
        <property type="entry name" value="ePHD_BRPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15492">
        <property type="entry name" value="PHD_BRPF_JADE_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000008">
        <property type="entry name" value="Bromodomain containing 1, isoform CRA_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000007">
        <property type="entry name" value="Bromodomain containing 1, isoform CRA_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019542">
        <property type="entry name" value="Enhancer_polycomb-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034732">
        <property type="entry name" value="EPHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050701">
        <property type="entry name" value="Histone_Mod_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793:SF107">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793">
        <property type="entry name" value="PHD FINGER PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10513">
        <property type="entry name" value="EPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13831">
        <property type="entry name" value="PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13832">
        <property type="entry name" value="zf-HC5HC2H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51805">
        <property type="entry name" value="EPHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="9">
        <location>
            <begin position="429"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="10">
        <location>
            <begin position="483"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="187"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="395"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="953"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1018"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1143"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1201"/>
            <end position="1239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1263"/>
            <end position="1283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1064"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1086"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1102"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="1225"/>
            <end position="1239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK4043238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="1300" mass="141409" checksum="DDF990D4DA76CEC2" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SV85</accession>
    <name>A0AAN6SV85_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Pyridoxal phosphate-dependent transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_32497</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the group II decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854328">
        <property type="protein sequence ID" value="KAK4043371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SV85"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1340.10">
        <property type="entry name" value="dopa decarboxylase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010977">
        <property type="entry name" value="Aromatic_deC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021115">
        <property type="entry name" value="Pyridoxal-P_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999">
        <property type="entry name" value="GROUP II PYRIDOXAL-5-PHOSPHATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999:SF70">
        <property type="entry name" value="MIP05841P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00800">
        <property type="entry name" value="YHDCRBOXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00392">
        <property type="entry name" value="DDC_GAD_HDC_YDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 6 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4043371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="503" mass="55351" checksum="EE025CC01979F6FC" modified="2024-10-02" version="1">MDSQGFREAATATIDEIITYFDTLASRNVVSSVEPGYLRKLLPAEAPQDGEPWAAIQQDMEAKIMPGITHWSHPGFHAFFPCATSYPSILGELYSSALSGACFNWICSPAVTELETVVLDWLAKALGLPACFLSTGPTRGGGVIQGSASEAVLTAMVAARDKYLRETVPDTLEEGEREERVMVKRSRMVALATTLTHSSAKKAALILGCRFRAVRVREEDGYALTKAGLKAALEECKAQGLEPFFLAATLGTTDVCSVDDFEGISEALAEYVSPGEPGEVWVHVDAAYAGAALVCPEVQESTRIGLISRFHSFDMNMHKWLLVNFDASCFFVRDREWLVQALSVNQAVYGNKASDGGLVTDYREWQIPLGRRFRSLKIWFVLRSYGVKGLQEYIRRTIANGESFAEALRGRSDLFEIVTGPSFALTVFRLAAKTEGAPLEERNALTRALYEKVNATGKIWLTSTELDGRFAIRLMTAVRTTEKEHIETAVKTLVEVAEEVMRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SVK7</accession>
    <name>A0AAN6SVK7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_43240</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854323">
        <property type="protein sequence ID" value="KAK4043865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SVK7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861:SF1">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="4">
        <location>
            <begin position="179"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="13"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="65"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="89"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4043865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="365" mass="40151" checksum="14B1737D2FF7F289" modified="2024-10-02" version="1">MQNPTPTQDPNSPTQDTAPTQDAAQAQDAAQTQDAPSQSRDSNSPTREAASPTATQEPTAPAQDPTLTRDPSLSNSPVPARVPAVDPTPTLQTVTQPGTTSDEPPPDLKQRIKESYDAIAVAYNQWALMHRSDRFDYVCRLIRLLQDDRSTNGAEEPDPDLPSTQDNIQIISLRGMQALEVGCGSGVPVLEVLLAKDMDTIGVDLSSTQIALAKAHFPNQMAALQAVWAEKDMMELRYPPDMFHVVVALYSLNHLPREEQTVFLARVHRWLKVGGMVMINFPQEEREGDVEEHWLGHPQGWMFWSSWGEEKMMQVIEGLEGMEVLVKEVKGGDGGDEDPKYVWVIARKNYETGEGPGEGGEGPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SVX6</accession>
    <name>A0AAN6SVX6_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glucanase</fullName>
            <ecNumber evidence="9">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">C8A01DRAFT_43040</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose and cellotetraose, releasing cellobiose from the non-reducing ends of the chains.</text>
            <dbReference type="EC" id="3.2.1.91"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 7 (cellulase C) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="9"/>
    <dbReference type="EMBL" id="MU854321">
        <property type="protein sequence ID" value="KAK4044106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SVX6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016162">
        <property type="term" value="F:cellulose 1,4-beta-cellobiosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.100.10">
        <property type="entry name" value="Glycoside hydrolase, family 7, domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001722">
        <property type="entry name" value="Glyco_hydro_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037019">
        <property type="entry name" value="Glyco_hydro_7_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33753">
        <property type="entry name" value="1,4-BETA-D-GLUCAN CELLOBIOHYDROLASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33753:SF2">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00840">
        <property type="entry name" value="Glyco_hydro_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00734">
        <property type="entry name" value="GLHYDRLASE7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 9" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="7 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042907517" description="Glucanase" evidence="10">
        <location>
            <begin position="20"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK4044106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="416" mass="46144" checksum="BE656BCC5146E097" modified="2024-10-02" version="1">MRWSHLTSSFLLCQGLTAAQQVGSYQNETHPKLQWSSCTVDGGCQTVNGEIAMDANFRWLHKVDNYMNCFSGNTWEENQCSTVENCTNTCALDGADYARVYGVKVTNSSVSQRFKTNFDFAYNVGSRLFLLESKHKYQMFTLKNNELAFDVDLSTVECGINGALYFVPMDADGGQTRYATNKAGAEYGTGYCDASCPRDLKFVGGKANMEAWIPSETDPFSGKGLYGACCPQFSVWNSNAHSFEMSSHVCPPDRAGPTVCGYEECDNYGPYGGQNHWRGQCDRWGCSYNPYRMGNTAFYGKGKTVDTGRKFTVVTQWSETKVTQFFIQDGQKIELPAPVVEGLPKEAGLSADMCSKQRAVFGELDTMAQNGGWETHNRQLLSQPMVLVMSIGADVHGGLVEHQIWAHWIYGSGLKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SW92</accession>
    <name>A0AAN6SW92_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNL zinc finger-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">C8A01DRAFT_42847</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854319">
        <property type="protein sequence ID" value="KAK4044421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SW92"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024158">
        <property type="entry name" value="Mt_import_TIM15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007853">
        <property type="entry name" value="Znf_DNL-typ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20922">
        <property type="entry name" value="DNL-TYPE ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20922:SF13">
        <property type="entry name" value="DNL-TYPE ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05180">
        <property type="entry name" value="zf-DNL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51501">
        <property type="entry name" value="ZF_DNL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNL-type" evidence="6">
        <location>
            <begin position="101"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="178"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="14"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="64"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="85"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAK4044421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="229" mass="24831" checksum="441C183A0CE57DCC" modified="2024-10-02" version="1">MASKRAFASIPNIARLASPSPARASAARALLRPRHHLPVSLASTTARLAHSIPRPRTASPFNEQQPPTATTTTSSTPEPTPPTSSSPQPDAAPQGGPPNIRQQPHYELTFTCRPCSTRSRHRISKQGYHHGSVLVTCPSCKNRHVIADHLRIFGDTATTIEEILKQKGELVKKGTLGEEGDLEFWDDGSSSPREPWVEVEGESKKGEGEDLPPGATFKSVRPGDRKAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6SWJ7</accession>
    <name>A0AAN6SWJ7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heterokaryon incompatibility protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_11747</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854316">
        <property type="protein sequence ID" value="KAK4044900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6SWJ7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="61"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4044900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="584" mass="65060" checksum="D4FF10DB822783BA" modified="2024-10-02" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P4P0</accession>
    <name>A0AAN6P4P0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glutathione S-transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_51363</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854747">
        <property type="protein sequence ID" value="KAK4031614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P4P0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00299">
        <property type="entry name" value="GST_C_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00570">
        <property type="entry name" value="GST_N_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050983">
        <property type="entry name" value="GST_Omega/HSP26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968:SF13">
        <property type="entry name" value="GLUTATHIONE TRANSFERASE OMEGA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13410">
        <property type="entry name" value="GST_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="27"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="3">
        <location>
            <begin position="115"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4031614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="283" mass="32352" checksum="9491C93A8BBBF4E2" modified="2024-10-02" version="1">MSTIDTSITPTPTGAAGRLAAAHSSPQPLTLYGSWFCPFVQRVWMVLHEKNIPHHYVEINPYKKEKHFLEMNPRGLVPTVTIELSDGKKEWLDEMYSDEKKYGGRLLPAGDGEREVFERARCRLWMNHVATRVVPGFYRLLQWTEAAEDGSSKQEKTIEEVRGEFLAAVKAFAREMLESDAGKGGPWFLGERFSLVDVMFAPWAKRLWLIDHYKPGGVGIPGKGERGEDEEVWARWDKWYEAVVERESVKATWSDEDRYIESEVGQATRKGQEFALRTARAAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P5Y2</accession>
    <name>A0AAN6P5Y2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_41188</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854618">
        <property type="protein sequence ID" value="KAK4032373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P5Y2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24296">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="431"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="431"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="443"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="474"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4032373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="530" mass="59403" checksum="D7993A9A8EA73F43" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P722</accession>
    <name>A0AAN6P722_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipocalin-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_50378</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854562">
        <property type="protein sequence ID" value="KAK4032941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P722"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024311">
        <property type="entry name" value="Lipocalin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13924">
        <property type="entry name" value="Lipocalin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipocalin-like" evidence="1">
        <location>
            <begin position="6"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4032941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="167" mass="18145" checksum="FDB0A80A23B7A20B" modified="2024-10-02" version="1">MVNIAGVWNLISFNYLLNGTSILQPNGPHPLGKITIMPEGYLSVQITTPEAAVPIPGGVKWGDASDAEIAAIARPYVAYSGKYVTSYVGDQLVLTTTVDVALDPSWMTRPQRRNATLFKENGTDYMILRPVGTIPMTLPGNITGDIVSELIWEKEIAICRKRSVPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P7J9</accession>
    <name>A0AAN6P7J9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_51217</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854693">
        <property type="protein sequence ID" value="KAK4031838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P7J9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4031838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="136" mass="15519" checksum="577E037B4EAE8C98" modified="2024-10-02" version="1">MGSALSRCTSRHSAAAPSGLPEMGQKILDRQPNWLVPPARWRTQPSNQHPVRYRTPTPYPKDDRKRMEEPAHVTTIKSPEKAFILETAAASHVEVTNPQRKRTLMHPRKPLVQTPQTALKITWEVSPRLNRFERAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P7S9</accession>
    <name>A0AAN6P7S9_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chaperonin 10-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_19679</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854535">
        <property type="protein sequence ID" value="KAK4033349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P7S9"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="4">
        <location>
            <begin position="13"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4033349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="349" mass="36175" checksum="E842AF59112F2146" modified="2024-10-02" version="1">MASNKAAWLREANTPPEVGEAPMPTAGPNELVIRNAAVAINPLDCHMLSAGVFVKEWPAIFGCDVAGVVHEVGSDVSGRFNVGDRVIGHAINLVSGRPQDGAFALYTVVPADKAAILPANIPFTEGVVVPFALEAAVCALSVTEPGTALPNVPTPALGLPYPSLEPAPPANKTLIVYGGSSSVGSMTTQLATAAGVHVIAIASARNFDLCRRCGAAEVFDYHDPAFVDQVVEAATAKPGHEFVGIFDAVGTPETYANGLTVLDRLGGGHLASVHPPPENVPDNVKAGMIFAVDDVAAPVWRDYVTPALREGKLKCLPAPLVVGKGLEYIQVALKRCEAGVSATKLVVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P7Z7</accession>
    <name>A0AAN6P7Z7_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CYTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_51488</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854818">
        <property type="protein sequence ID" value="KAK4031416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P7Z7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4031416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="267" mass="30082" checksum="730DADAD622A368C" modified="2024-10-02" version="1">MTPDYEVKLRMDPDNVLNPSDYKLTATVLSTFAIPTTVIKMNVQFLDKSNKEIYDNGWSPRIRKTEDENNFELTYKKRYSIANGDIDAALATANKEGFAAEETDYEAQVELTYEKQTLSISRKRTASDAGYSGIDLPDTRDSRDMLINQAPDKFDDWVSNGWGTTALASARIFGPILAKRSIGIWNGTKLYIEVWPITNATGPGTEYIVEVSLKTASRTTASEKCDALRAFLQQQGWFLREASLKTQLIMDRYGHKTDCPRPAKVHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P8A0</accession>
    <name>A0AAN6P8A0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Thiamine pyrophosphate enzyme, N-terminal TPP binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_49858</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854521">
        <property type="protein sequence ID" value="KAK4033579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P8A0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005948">
        <property type="term" value="C:acetolactate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07035">
        <property type="entry name" value="TPP_PYR_POX_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006203">
        <property type="entry name" value="PRK08327.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968:SF164">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="THIAMINE PYROPHOSPHATE ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="7">
        <location>
            <begin position="105"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="5">
        <location>
            <begin position="308"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="6">
        <location>
            <begin position="517"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="23"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="52"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4033579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="689" mass="73875" checksum="8316A802B84AF400" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P8F1</accession>
    <name>A0AAN6P8F1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Snf7 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_39887</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854517">
        <property type="protein sequence ID" value="KAK4033654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P8F1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF12">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="35"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4033654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="217" mass="24020" checksum="AEB87B2759BB40B6" modified="2024-10-02" version="1">MNRLFGTTAPKPPKATLNSAISNIDTRISSIDVKLASINAELQGYQTKLSKLREGPGKTALKQKALKVLQRRKQYEAQRDQLQSQVWNMEQAQTMQDNLKNTMVTVDALKSTNKALRKEYGKVDIDKIERLQDEMADLLDVGNEIQESLARSYDVPEDVDEAELDAELEALGQEVELERELAGGGMEGALPSFMQDEVPDFIDEAPTPAGQVKEAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P8I2</accession>
    <name>A0AAN6P8I2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_39807</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854513">
        <property type="protein sequence ID" value="KAK4033721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P8I2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="235"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4033721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="263" mass="29268" checksum="81C9DB059001B8A1" modified="2024-10-02" version="1">MSRPYVVGDSSPFLKRVLIPFWVVRILIMLIYIAVFGVLVTGLGVYKNRIDRLTDEYGTTLNYNAVLAVACIIIAITLVCLILDIVCIIMRARRTLTPPFFLGVNIAQSIIFLVEFILSMIGPRPGTLSIIIGVLILLSFLGLLIYAAVVFHQYRKGSLQTRGTYVQANNPEAHNLVANTAYPGIAPVPVPHTSYPQQSYVQEYPPKAAAQAYGDHEGYAAPAYEPYRQTTGHEQPAQGFMQQQQQEHQPPQHGYEMHQRPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P8K0</accession>
    <name>A0AAN6P8K0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aspartic peptidase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">C8A01DRAFT_20581</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854622">
        <property type="protein sequence ID" value="KAK4032333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P8K0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042907328" evidence="3">
        <location>
            <begin position="17"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="4">
        <location>
            <begin position="67"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAK4032333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="430" mass="46456" checksum="FA8AC8C40D2419BC" modified="2024-10-02" version="1">MKLLLWLALHLGLAWGAALPEAAVSLDPVPQHLSPFQLGGLSKRGGHGRPVNIDLEVWRRGQTELQWYGEITVGTPPQKFKLVFDTGAGLMLIAHKNCTTCGTHPLCDPSASTTFSAQPGYKLEVTFGSQGGGTTSTPEVQGANCTVVTDTVRMAGRGDDVYSEFLICDNYSSGLREQDPDGIFGIGLTPDGNWDETQGNATAFKPVFWNLVASGQIPGPEFSFSFISDRRGPRGGRAGVLTLGGTDRSQYIPSTLKTIPLNRPLSELRTRWVVDVRGARIGGYTLANSTDAVTLVDSGGATIITPDKETTQELYGRMSDQIKPLDARGAWGAPCDVLDRAVRDVTFTVGTAAQHVDAVVKKEYINVGEYAGKPGICQGVFTDPDRVAREPINGRPAWIFGTPWLRSYYTVWNGVERTIGFATPSHRDRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P911</accession>
    <name>A0AAN6P911_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_49576</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854503">
        <property type="protein sequence ID" value="KAK4033910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P911"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042832859" evidence="1">
        <location>
            <begin position="21"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4033910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="230" mass="26165" checksum="7EC31F86431FC1BC" modified="2024-10-02" version="1">MAFLKSVFIRLRLLACLAFAARCCSKLSRIDALIVQWPRWYTDVGFPAVVRELSFLNTLDTAGPVAASQEEWAYCVLFLSSRTRCNPIATQLAYHRYEQFLRREASCTFVANAISQLLPVLGTYLRLQRLNPGRYRYKTIRHLCLNAVLAGKGLDDSIANFLGFCDIVGTWVPENELFGFTEHHPLNRLTLKQPNIVCEGILPSRDSEGYLIEDPFPDPNYNIPILSLLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6P9I4</accession>
    <name>A0AAN6P9I4_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">4'-phosphopantetheinyl transferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_49352</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854489">
        <property type="protein sequence ID" value="KAK4034218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6P9I4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="entry name" value="4'-phosphopantetheinyl transferase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4034218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="174" mass="18428" checksum="7C4D867006CF2C65" modified="2024-10-02" version="1">MPPPLPFPYPLRIGTDICRVARIAHILRSKQASRFIRRVLAPEELARAKPAIHQVLEAAAQARRGDAHGIRDSGVLRRGQAEESGDGQVGPTKEAAFKAHPHLRLGFHDIVILSSSDAESVTGEKALTGLGSAAPVALIRAGNGEGARDQMAKVSISHDGEYATAVCLGFEADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PA27</accession>
    <name>A0AAN6PA27_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein AF-9 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_40992</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854596">
        <property type="protein sequence ID" value="KAK4032556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PA27"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16908">
        <property type="entry name" value="YEATS_Yaf9_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1970">
        <property type="entry name" value="YEATS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038704">
        <property type="entry name" value="YEAST_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005033">
        <property type="entry name" value="YEATS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055129">
        <property type="entry name" value="YEATS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47573">
        <property type="entry name" value="PROTEIN AF-9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47573:SF1">
        <property type="entry name" value="PROTEIN AF-9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03366">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51037">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="YEATS" evidence="8">
        <location>
            <begin position="8"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="168"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="225"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="168"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4032556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="269" mass="30669" checksum="3F96FA7DDC87A249" modified="2024-10-02" version="1">MAPPTGKRVKGVQIYRPFVYGTTAKPFDEKTNPKPPGVPDDHTHSWTVFVKGIDDVDITYWLRRVQFKLHESIPNHVRMIEGEKNKPFLLHETGWGEFEITIKLYYVPESSEKPQTLYHHLRLHPYGRTDEEKENMRLNGGQVLSWAYEEQLFNEPYEPFYEILTSGAMPPASSTPTTTKSGSKGGGGKSGKDKDQIKMIRSEGGVLERSAMIPLTNRPGQPFSRETEQVEIKKLREALVKVEELMDKTKEEVAGKERRLKELKADAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PA38</accession>
    <name>A0AAN6PA38_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_20359</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854594">
        <property type="protein sequence ID" value="KAK4032571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PA38"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12087">
        <property type="entry name" value="TM_EGFR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042917831" evidence="3">
        <location>
            <begin position="29"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="107"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4032571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="263" mass="27418" checksum="2545DB929490BA22" modified="2024-10-02" version="1">MKLSRHSFPPGRCFFAAAVLLDLHVASAQTFKYAEGATPTEFQGFVTTAPGLSKVSPMLSSGTIPNCYTMTIYQSFPSAAQSWSAIGCAPPGFNASTLYREIVVGATTTTPSPGPSTRPTGTAPSGPSSTPVKTSAAPEPTHDEPANTPQTNPPTSQAWIAGAVIGPVAAIALATFLVFWLRRRKVGRGEMKGGIPRGHVGDQEFESATVQSTSSPPMFKSELGGGGVSTVVELADHRPFELDAYPVVSNGAVGYENGSWGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PAF8</accession>
    <name>A0AAN6PAF8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_38817</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854468">
        <property type="protein sequence ID" value="KAK4034713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PAF8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="2">
        <location>
            <begin position="6"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4034713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="342" mass="39769" checksum="13DC7469D9B44B30" modified="2024-10-02" version="1">MEPRTFHLFPLLPKELRDAIWALAIRPERPSAHFFTVFDSSNDAEWSLLSQHSIRHPLVKRCSLAAPQPRRDTFDNDHQQQQQQQQQQFSWIRGNRSAYLIDSGLWTACTESRDAMERLFKVAEWDIKRAAMRLPSPIRDLPDASATVSFSSNDEWQRCLTHPKTDLFLLLPFDGEMVDWEDLGRPVPIFDAVEKFYVGHIALDYDPGWLMEGDYLDPYDSWASPGTIGCVIRAATNQLDWAENLWFVDYRIRRHPGALLTTTNRHQFHGNGCKFTEVREGDTDWKVNHSKSIFKFLEELVEKVEYFCHREGYSPGYVFVYGTLDVGILAYEEYGPRNSSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PAQ3</accession>
    <name>A0AAN6PAQ3_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_38644</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DPH1/DPH2 family. DPH2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854462">
        <property type="protein sequence ID" value="KAK4034879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PAQ3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090560">
        <property type="term" value="F:2-(3-amino-3-carboxypropyl)histidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11860:FF:000001">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11860">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042265">
        <property type="entry name" value="DPH1/DPH2_3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00322">
        <property type="entry name" value="diphth2_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762:SF2">
        <property type="entry name" value="2-(3-AMINO-3-CARBOXYPROPYL)HISTIDINE SYNTHASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01866">
        <property type="entry name" value="Diphthamide_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00032">
        <property type="entry name" value="Radical_SAM_3-amino-3-carboxyp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="133"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="133"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="146"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00080784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4034879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="281" mass="29597" checksum="6AF2EB9EA1AA8A30" modified="2024-10-02" version="1">MAVYTPPFSTPRLLGRRYARLLTLASAGIIGILVNTLSVSNYLSSIDAIRAQIAAAGKKSYTVVVGKLNPAKLANFAEVDGWVVVGCWESSLVEDDAGFYRPVVTPFELGVALVGDERRVWSGEWWGGIEGVGGVQGGLGGGESQGEERSGGGRDGERNEKEDDEEESAPPEFDLRTGKLVSHSRPLRNGTPKANGKVKQEGGAAGGKSGGDAPSSSVLALRPKAELAMVNGVVSPGAEYLRSQRTWQGLGSDYVAEESTAIEEGRSGVARGYTVGDQEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PAU8</accession>
    <name>A0AAN6PAU8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_39560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854501">
        <property type="protein sequence ID" value="KAK4033952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PAU8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.60.10">
        <property type="entry name" value="Penicillin V Acylase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047794">
        <property type="entry name" value="C45_proenzyme-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047801">
        <property type="entry name" value="Peptidase_C45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005079">
        <property type="entry name" value="Peptidase_C45_hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040521">
        <property type="entry name" value="C45_proenzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34180:SF1">
        <property type="entry name" value="BETA-ALANYL-DOPAMINE_CARCININE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34180">
        <property type="entry name" value="PEPTIDASE C45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03417">
        <property type="entry name" value="AAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C45 hydrolase" evidence="2">
        <location>
            <begin position="182"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="460"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="487"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4033952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="547" mass="59738" checksum="5B181A808720D216" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PC79</accession>
    <name>A0AAN6PC79_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glucan endo-1,3-beta-D-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">C8A01DRAFT_17933</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;3)-beta-D-glucosidic linkages in (1-&gt;3)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.39"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PGA52 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.39" evidence="3"/>
    <dbReference type="EMBL" id="MU854445">
        <property type="protein sequence ID" value="KAK4035404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PC79"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018805">
        <property type="entry name" value="YJL171C/Tos1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018807">
        <property type="entry name" value="YJL171C/Tos1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31737">
        <property type="entry name" value="PROTEIN TOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31737:SF2">
        <property type="entry name" value="PROTEIN TOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10287">
        <property type="entry name" value="YJL171C_Tos1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10290">
        <property type="entry name" value="YJL171C_Tos1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Cell wall protein YJL171C/Tos1 N-terminal" evidence="10">
        <location>
            <begin position="39"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Cell wall protein YJL171C/Tos1 C-terminal" evidence="9">
        <location>
            <begin position="302"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="245"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="245"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF10290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAK4035404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="556" mass="58486" checksum="00C43F82DA4066E6" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PCY6</accession>
    <name>A0AAN6PCY6_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_49742</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854513">
        <property type="protein sequence ID" value="KAK4033722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PCY6"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="507"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="600"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="600"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4033722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="630" mass="67362" checksum="E0ABE0B707E5E8BB" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PD01</accession>
    <name>A0AAN6PD01_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">arginyltransferase</fullName>
            <ecNumber evidence="2">2.3.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_47717</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the R-transferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.8" evidence="2"/>
    <dbReference type="EMBL" id="MU854421">
        <property type="protein sequence ID" value="KAK4038694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PD01"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004057">
        <property type="term" value="F:arginyl-tRNA--protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030700">
        <property type="entry name" value="N-end_Aminoacyl_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007472">
        <property type="entry name" value="N-end_Aminoacyl_Trfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007471">
        <property type="entry name" value="N-end_Aminoacyl_Trfase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21367">
        <property type="entry name" value="ARGININE-TRNA-PROTEIN TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21367:SF1">
        <property type="entry name" value="ARGINYL-TRNA--PROTEIN TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04377">
        <property type="entry name" value="ATE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04376">
        <property type="entry name" value="ATE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-end aminoacyl transferase N-terminal" evidence="6">
        <location>
            <begin position="23"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="N-end rule aminoacyl transferase C-terminal" evidence="7">
        <location>
            <begin position="171"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="338"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="354"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4038694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="461" mass="52257" checksum="BCB2D2EF67E8B00D" modified="2024-10-02" version="1">MQTPGDVAPRYSFLFPIGYSNSSECGYCRNTRSGQSTKRYSYYAIATSLTPAFYQKLVNRCWRRSGTLLYRPNQKHSCCPHYTLRLDSTQFKPTKDQRQAVNRFNRHIIGDAYASEAARLHPRSRAEARRRHNVFDLVERVHEPEAEFLKSPPSPDHAFAVTLEPDTFTEEKYAIFENYQRVVHREPPDKISRHGFKRFLCNSPLSRGSTAAGGPDGKARPLGSFHQCYRIDGKLVAVGVLDLLPDCVSAVYFLYHESIHWLNPGKLGALREIALAREAGYRWWYPGYYVHNCAKMRYKIEYKPQYVLDPEDLRWYLLDKEALARFDRGHYVCFSRKEEEGGGHGQGVDIPATTGESSENGNTAEEEDAQEAAGEEDAFLLASNMPGIPTLADMARVDMDRLVLRADFSDNLIVASHLVIWDTEDIAQPGTLKSRIAELVAAVGPDLLGEICIDFRKRSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PD52</accession>
    <name>A0AAN6PD52_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">C8A01DRAFT_49045</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854473">
        <property type="protein sequence ID" value="KAK4034583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PD52"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAK4034583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="290" mass="33360" checksum="73A8963A494DB5F4" modified="2024-10-02" version="1">MDPAGTLKQQQDLEIWREPWEKEMAKLPPDLRRPFLDPRPFNIATHARKIIDLLEEHGIPCCVTGTKALCYYGAPRICSTLEFCVPTEQLATADYIFSSGPAKENYTAWKGRQPGAEAWVSGSLYHTFPRYRLNHDGHLFGFYLVPSIDWRFDCAPENFEYSAQKHIPYPKLNLFAQSLLERQDTGDLQDLVDGMDLTEEWGEGNLKFDDPGTEIREATPQEVKDDPINVMFGTEVYELPEGPTDFREVFARLVRTKSRRIGLESPPGLYDTKYRAKDSPDPRTRIRFHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PDD7</accession>
    <name>A0AAN6PDD7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_37248</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854418">
        <property type="protein sequence ID" value="KAK4038838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PDD7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4038838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="107" mass="11423" checksum="03FABAB9C04C76C8" modified="2024-10-02" version="1">MSSRYSSGVVVVQASSRSSTYSAPRSSSSTTYSSSYAQTSFSMDSSSASRSTTEARYRSGSSSGFYTDVKEVPSSRGGSNLVVVQHNRPNPDKNEPRSYSGSSYGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PDJ0</accession>
    <name>A0AAN6PDJ0_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Concanavalin A-like lectin/glucanase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_39181</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 12 (cellulase H) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854483">
        <property type="protein sequence ID" value="KAK4034356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PDJ0"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013319">
        <property type="entry name" value="GH11/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002594">
        <property type="entry name" value="GH12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34002">
        <property type="entry name" value="BLR1656 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34002:SF10">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01670">
        <property type="entry name" value="Glyco_hydro_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042921602" evidence="3">
        <location>
            <begin position="16"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4034356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="251" mass="27099" checksum="A0D5F9D76FBC65A1" modified="2024-10-02" version="1">MLKLIPFFLASLAAAAPAGRYPLHRRQDVATLCEKNGYWSGNGYEVNNNNWGAASATSGSQCTYVDSSSSGSVAWHTTWTWEGNEGRVKSYANSGKQIARGQTIASIESMATSVSWQYNTSDIRANVAYDFFTAEDPNHSSTGGDYELMIWVAAFGNVAPIGSSTGTVTIAGDSWDLYAGHKGAMEVYTFKATSNMDSFSTDVKEFFNYLKDNEDFPADSQNLIAFQFGSEAFTGGPATLDVSRFSASVVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PDN2</accession>
    <name>A0AAN6PDN2_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">C8A01DRAFT_16908</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854411">
        <property type="protein sequence ID" value="KAK4039054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PDN2"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015343">
        <property type="term" value="F:siderophore-iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000197">
        <property type="entry name" value="Siderophore iron transporter 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF92">
        <property type="entry name" value="GLUTATHIONE EXCHANGER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="182"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="211"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="343"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="373"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="404"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="442"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="518"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAK4039054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="708" mass="76475" checksum="4B0AA93F6F10C966" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PDP3</accession>
    <name>A0AAN6PDP3_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">C8A01DRAFT_17249</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854421">
        <property type="protein sequence ID" value="KAK4038712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PDP3"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="182"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="282"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="380"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAK4038712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="424" mass="45042" checksum="0B1572B4A7BE1CB3" modified="2024-10-02" version="1">MKSWLAAKTEEDKRRQEEERTRQESYRLEQRRMEYDILRTSLQGGIPPPLVPVVFAGMGGGALSPAALDWAQQFMMSQSPQQHPPALMPPGTVSSEHPRRDSQAHAYGQYPVSGGGVPSTPGSAQGPPSAYMTGYPGSPTRPRGLSMPGAMAGRPLVGGGPNLPNLNTNVPGGPGHQPGLAQSQQPQQQETQPSPSIYFHHWQPPTTQAGGGRGGAEQPATPSVGESPRKRKAPGPQQPAPPPSTTHRHRSPPFPHSTGLSNPPPGRRRGHSRQRSDLGQYRSGAGRARGESSGPGREMSPMHTSGASSVRDNGEPSSSAQHQTQVSQFAPPPAQAPSGRAGAHSVSSLLSDHLQSPRARTTTHFASSGPPSEARHHHQQQMQQHAQPHFGEGERRQSPRLSEENLRGGGGVQGSTATRPGDNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PDQ1</accession>
    <name>A0AAN6PDQ1_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HotDog domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_16888</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase PaaI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854411">
        <property type="protein sequence ID" value="KAK4039062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PDQ1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000033">
        <property type="entry name" value="acyl-coenzyme A thioesterase 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039298">
        <property type="entry name" value="ACOT13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003736">
        <property type="entry name" value="PAAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00369">
        <property type="entry name" value="unchar_dom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660:SF57">
        <property type="entry name" value="PAAI THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660">
        <property type="entry name" value="THIOESTERASE SUPERFAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="3">
        <location>
            <begin position="62"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4039062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="173" mass="18346" checksum="E07CA8AE6E759DCB" modified="2024-10-02" version="1">MATNAGTKLSHLRFVRTVLNSFMAESGLEPRLLGKHFRICNASEGVVDFELVIAKEHTNRLKIIHGGTIASLVDLGGSLAVASKGYYATGVSTDLNVTYISSGGKVDDKLRGTAVCDRIGKTLAYTTVTFWDNQRNMVARGSHTKFVAQAVAASTPFTAPAGAPIAEDGEPSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PER4</accession>
    <name>A0AAN6PER4_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_38896</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854471">
        <property type="protein sequence ID" value="KAK4034637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PER4"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042819237" evidence="2">
        <location>
            <begin position="21"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4034637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="247" mass="25391" checksum="E571EAF910BB76DD" modified="2024-10-02" version="1">MRQSAVLYLLAAAGVANAAGQPLVPNSVSMPGAGLFARQFDVCTSQNTCAQCYGEGWVICDTIGCFNPEIHQQCCAFASLCVGKTNNCCKDWGGPGVTGTSGVPNVTAFPRPTESTVSYECRRGDTGEECCQRAPTPLHWCAGDFPNFACYNDKNQFCCTDGTVCDEEDCCDLFDAETTHPWAATATNPPTATSAPTTTVTTGSVTNAPTVAAASTSTTASTSTSTAGASLSGPGLMAIGLAAFGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PEX7</accession>
    <name>A0AAN6PEX7_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FAD binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">C8A01DRAFT_47623</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854418">
        <property type="protein sequence ID" value="KAK4038818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PEX7"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050315">
        <property type="entry name" value="FAD-oxidoreductase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43400">
        <property type="entry name" value="FUMARATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43400:SF12">
        <property type="entry name" value="FUMARATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-dependent oxidoreductase 2 FAD-binding" evidence="3">
        <location>
            <begin position="9"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAK4038818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="507" mass="53399" checksum="6C62361A3D58F8FC" modified="2024-10-02" version="1">MANPHPPPVIVVGAGLAGLSAAYAALLAGAPSVRLLERAAKPGGNSIKASSGINGAPTRFQDVAKYGVDQSFWDDTVRSAGSRLQASVAEPIRNQRQGLISILTNRSASAIDFLADLGVDLSVVAQLGGHSKPRTHRGAGRTPPGAAIVTTLLAKLKEQGDRFELVTEAEVTKLLLLPAPHENSKAQPHPQAVVVTGVEYRLHNLDTTQTLHGPVVFAPGGFAGDTHGLLSLHRPDLAGLPSTNDPRPAAHTLLSAAGAKLVDMESVQVHPTGFVDPANPQAALKFLAPEMLRGEGGVLLYRGRRVVNELATREVVSRVIMALPPSAAADDEDHVGDRLRQWDVQLLLDPGTAEAAAGHVVFYLWKGLLRKKKVRELDEVTRETLREYARVVRGERADGLGRVAFGHWTLGVAGAGDIDEEAEVCVGSVTPIVHFTMGGAVFNERAQILSSELGEEEKPIQGLWGAGEITGGIHGDNRLGGSSLLECVVFGRIAGEQAAQSALKAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PF31</accession>
    <name>A0AAN6PF31_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">uS12 prolyl 3,4-dihydroxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">C8A01DRAFT_16280</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>[ribosomal protein uS12]-(3S)-3-hydroxy-L-proline + 2-oxoglutarate + O2 = [ribosomal protein uS12]-(3S)-3,4-dihydroxy-L-proline + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:54160"/>
            <dbReference type="Rhea" id="RHEA-COMP:13817"/>
            <dbReference type="Rhea" id="RHEA-COMP:13818"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:85428"/>
            <dbReference type="ChEBI" id="CHEBI:138052"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[ribosomal protein uS12]-L-proline + 2-oxoglutarate + O2 = [ribosomal protein uS12]-(3S)-3-hydroxy-L-proline + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:54156"/>
            <dbReference type="Rhea" id="RHEA-COMP:13816"/>
            <dbReference type="Rhea" id="RHEA-COMP:13818"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:50342"/>
            <dbReference type="ChEBI" id="CHEBI:85428"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TPA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854392">
        <property type="protein sequence ID" value="KAK4039768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PF31"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031543">
        <property type="term" value="F:peptidyl-proline dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009896">
        <property type="term" value="P:positive regulation of catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010604">
        <property type="term" value="P:positive regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006449">
        <property type="term" value="P:regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.620:FF:000014">
        <property type="entry name" value="Prolyl 3,4-dihydroxylase TPA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019601">
        <property type="entry name" value="Oxoglutarate/Fe-dep_Oase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039558">
        <property type="entry name" value="TPA1/OFD1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051842">
        <property type="entry name" value="uS12_prolyl_hydroxylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12117">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12117:SF0">
        <property type="entry name" value="PROLYL 3-HYDROXYLASE OGFOD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13661">
        <property type="entry name" value="2OG-FeII_Oxy_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10637">
        <property type="entry name" value="Ofd1_CTDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0847">Vitamin C</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="14">
        <location>
            <begin position="143"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="293"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="463"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="624"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="312"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="523"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="624"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00081607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAK4039768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="663" mass="73655" checksum="33561ABAF94E0E27" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PF89</accession>
    <name>A0AAN6PF89_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">O-methylsterigmatocystin oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_18325</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854460">
        <property type="protein sequence ID" value="KAK4034937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PF89"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF2">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ALNH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042892576" evidence="8">
        <location>
            <begin position="26"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="409"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="413"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="440"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4034937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="535" mass="59844" checksum="9E454ED1B9A7D4B9" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PF97</accession>
    <name>A0AAN6PF97_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF2269 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">C8A01DRAFT_46991</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854397">
        <property type="protein sequence ID" value="KAK4039582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PF97"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42083">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42083:SF1">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042897103" description="DUF2269 domain-containing protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAK4039582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="154" mass="17585" checksum="C62F9B6B6CB2EB45" modified="2024-10-02" version="1">MAIGGWALSYLLFALLHFSQFVLAVTVCALYGIDLDRARRANVQADGKWVYAEVVGGLSALTAILYCIPFILRFALVWAWNLVLFILWIALFGIFGKMFINEDAKGNGDMQRMKNAVWVVLASAILWLIGVLAHFIYWWAHRERRSRFTSRARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PFJ8</accession>
    <name>A0AAN6PFJ8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_48660</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854455">
        <property type="protein sequence ID" value="KAK4035102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PFJ8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04077">
        <property type="entry name" value="Peptidases_S8_PCSK9_ProteinaseK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000007">
        <property type="entry name" value="Subtilisin-like serine protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="entry name" value="Peptidase S8 propeptide/proteinase inhibitor I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034193">
        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF58">
        <property type="entry name" value="ALKALINE PROTEASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S8/S53" evidence="7">
        <location>
            <begin position="138"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAK4035102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="388" mass="40583" checksum="C249DDA3637A58BB" modified="2024-10-02" version="1">MTGLSELNNGVLAELVIPDTYIVKYKANVDIRGRTKHEEDVDSWARLSSRRGILDKFDVPGLQGYVAEISLLELANLTACDLIDYVEKDTIVRTTAVAADPALAKRYMTTQYNAPWGLGRISHTAPNQRDYDYSDSAGKDIFVYVVDTGIRLSHDDFGGRAVWGANFIASSPNSDQDGHGTHVAGIIAGQTYGVAKKATVVAVKVLGDTGSGSMSGLLQGINWAAADAKQRGVAGKAVINMSLSGAYTQSVNDAVKAAMDAGITVVAAAGNKDEDVSGWLPGSAATAITVGAIDMDDQRANFSNWGTAVDIFAPGVRIPSAYNGSDTDSAWLSGTSMASPHVSGLAAYFIAREGLSGSAVRKRILSVGNQGIGDRKGGADLIAYNAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PFL8</accession>
    <name>A0AAN6PFL8_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">26S proteasome regulatory subunit RPN1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">C8A01DRAFT_36925</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the proteasome subunit S2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854410">
        <property type="protein sequence ID" value="KAK4039090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PFL8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042176">
        <property type="term" value="P:regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000026">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016643">
        <property type="entry name" value="26S_Psome_Rpn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002015">
        <property type="entry name" value="Proteasome/cyclosome_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041433">
        <property type="entry name" value="RPN1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040892">
        <property type="entry name" value="RPN1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01851">
        <property type="entry name" value="PC_rep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18051">
        <property type="entry name" value="RPN1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17781">
        <property type="entry name" value="RPN1_RPN2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015965">
        <property type="entry name" value="26S_Psome_Rpn1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="RPN1 N-terminal" evidence="7">
        <location>
            <begin position="58"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="26S proteasome non-ATPase regulatory subunit RPN1 C-terminal" evidence="8">
        <location>
            <begin position="843"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00057191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR015965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAK4039090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="900" mass="100162" checksum="8B9095AC08D1A888" modified="2024-10-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PFP1</accession>
    <name>A0AAN6PFP1_9PEZI</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">C8A01DRAFT_15930</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854383">
        <property type="protein sequence ID" value="KAK4040149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PFP1"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051735">
        <property type="entry name" value="CFEM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928">
        <property type="entry name" value="CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G14090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928:SF1">
        <property type="entry name" value="CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G14090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00747">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="6 15" id="KW-0349">Heme</keyword>
    <keyword evidence="10 15" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="11 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="9 18" id="KW-0732">Signal</keyword>
    <keyword evidence="17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042980818" description="CFEM domain-containing protein" evidence="18">
        <location>
            <begin position="19"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="19">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="97"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="15">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="44"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAK4040149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001303115"/>
        </source>
    </evidence>
    <sequence length="285" mass="28806" checksum="61D3C737D6E606EE" modified="2024-10-02" version="1">MLGVRAVTLLSLAAFASAQTIESLESCGQQCYTNALNQAGQYACAANDMNCLCPNAEFNNAIHDCAKQACTPPEYAATVTNAVAAFCATATLPPGAAAPTSTTAPAAEPTSSTTSAPTSAPTESSTTAPATSSTSETSAATSTTLTTSATSSPSSTTSTPIATKVVTSSTSASTAGAAATSDAAVGAAPAGLTEAAKIGIGIGVGAAVIALLALAACVMLRKRRANQPSQAQLDRFKISHPMPSDEHAYTHNNNSDYDIGASGDLEMKSRRYEDMLPREEPRQMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-10-02" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAN6PFR8</accession>
    <name>A0AAN6PFR8_9PEZI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fungal transcriptional regulatory-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">C8A01DRAFT_47303</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Parachaetomium inaequale</name>
        <dbReference type="NCBI Taxonomy" id="2588326"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Parachaetomium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2023" name="Mol. Phylogenet. Evol." volume="189" first="107938" last="107938">
            <title>Genome-scale phylogeny and comparative genomics of the fungal order Sordariales.</title>
            <authorList>
                <person name="Hensen N."/>
                <person name="Bonometti L."/>
                <person name="Westerberg I."/>
                <person name="Brannstrom I.O."/>
                <person name="Guillou S."/>
                <person name="Cros-Aarteil S."/>
                <person name="Calhoun S."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="LaButti K."/>
                <person name="Andreopoulos B."/>
                <person name="Lipzen A."/>
                <person name="Chen C."/>
                <person name="Yan M."/>
                <person name="Daum C."/>
                <person name="Ng V."/>
                <person name="Clum A."/>
                <person name="Steindorff A."/>
                <person name="Ohm R.A."/>
                <person name="Martin F."/>
                <person name="Silar P."/>
                <person name="Natvig D.O."/>
                <person name="Lalanne C."/>
                <person name="Gautier V."/>
                <person name="Ament-Velasquez S.L."/>
                <person name="Kruys A."/>
                <person name="Hutchinson M.I."/>
                <person name="Powell A.J."/>
                <person name="Barry K."/>
                <person name="Miller A.N."/>
                <person name="Grigoriev I.V."/>
                <person name="Debuchy R."/>
                <person name="Gladieux P."/>
                <person name="Hiltunen Thoren M."/>
                <person name="Johannesson H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 284.82</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MU854408">
        <property type="protein sequence ID" value="KAK4039165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAN6PFR8"/>
    <dbReference type="Proteomes" id="UP001303115">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0